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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
methyl-CpG binding domain 4, DNA glycosylase
Summary
- Gene Symbol
-
- MBD4
- Aliases
-
- MED1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- DNA repair
- DNA-binding
- Disease variant
- Hydrolase
- Nucleus
- Phosphoprotein
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| O95243 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| depyrimidination | ||
| DNA repair | ||
| response to estradiol |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular catabolic process [inference]
heterocycle metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular catabolic process [inference]
heterocycle metabolic process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| nuclear speck | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| DNA binding | ||
| DNA N-glycosylase activity | ||
| satellite DNA binding | ||
| pyrimidine-specific mismatch base pair DNA N-glycosylase activity | ||
| DNA endonuclease activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0080195 | Marinesco-Sjogren syndrome | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:1019 | osteomyelitis | |
| DOID:10534 | stomach cancer | |
| DOID:11054 | urinary bladder cancer | |
| DOID:11266 | Hantavirus hemorrhagic fever with renal syndrome | |
| DOID:11661 | blue color blindness | |
| DOID:12849 | autistic disorder | |
| DOID:1324 | lung cancer |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0002858 | Meningioma |
| HP:0003003 | Colon cancer |
| HP:0003581 | Adult onset |
| HP:0003596 | Middle age onset |
| HP:0003621 | Juvenile onset |
| HP:0004808 | Acute myeloid leukemia |
| HP:0005227 | Adenomatous colonic polyposis |
| HP:0007716 | Uveal melanoma |
| HP:0011462 | Young adult onset |
| Disease ID | Disease Name |
|---|---|
| OMIM:619975 |
|
| OMIM:606660 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 104676628 | RHIRO30620 | ||
| 100594941 | NOMLE19703 | ||
| 106829352 | EQUAS01211 | ||
| 105299015 | PTEVA02965 |
ChIP-Atlas
- Target Genes
-
Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for MBD4
Distance from TSS: ± 10 kb
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| UDP glucuronosyltransferase family 1 member A1 |
|
|
| beta-1,4-galactosyltransferase 1 |
|
|
| solute carrier family 35 member B1 |
|
|
| interleukin 1 receptor accessory protein |
|
|
| ribokinase |
|
|
| dolichyl-phosphate mannosyltransferase subunit 1, catalytic |
|
|
| phosphatidylinositol glycan anchor biosynthesis class L |
|
|
| UDP glucuronosyltransferase family 1 member A4 |
|
|
| fucosyltransferase 5 |
|
|
| neuraminidase 2 |
|
- Colocalization
-
Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for MBD4
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| methyl-CpG binding domain 4, DNA glycosylase |
|
