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SEC16 homolog A, endoplasmic reticulum export factor

Summary

Gene Symbol

SEC16A

Organism

Homo sapiens (human)

External Links

NCBI Gene

9919

PubChem

9919

Alliance of Genome Resources

HGNC:29006

Annotation

Keyword

Alternative splicing
Cytoplasm
ER-Golgi transport
Endoplasmic reticulum
Golgi apparatus
Membrane
Microsome
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
F1T0I1
O15027	SEC16 homolog A
A0A8I5KPG1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein stabilization	IMP	29300766
autophagy	IEA
endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	17005010 22355596
Golgi to plasma membrane transport	IMP	28067262
Golgi organization	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular process [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

endoplasmic reticulum to Golgi vesicle-mediated transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

protein localization to endoplasmic reticulum exit site

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle coating [inference]

COPII vesicle coating

cellular component assembly [inference]

protein-containing complex assembly [inference]

COPII vesicle coating

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

COPII vesicle coating

developmental process [inference]

anatomical structure development [inference]

neural nucleus development [inference]

substantia nigra development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

protein localization to endoplasmic reticulum exit site

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

endoplasmic reticulum to Golgi vesicle-mediated transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

endoplasmic reticulum to Golgi vesicle-mediated transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

protein localization to endoplasmic reticulum exit site

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of COPII vesicle coating

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of COPII vesicle coating

regulation of protein-containing complex assembly [inference]

regulation of COPII vesicle coating

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IDA	29300766
endoplasmic reticulum exit site	IBA IDA	17005010 19638414 22355596 25201882 28067262
Golgi membrane	IEA
ER to Golgi transport vesicle membrane	IBA
cytosol	IDA TAS	17428803 21768384

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	17428803 19638414 22355596 25201882 28067262 28442536 29187380 29300766 31046837

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sec16

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
COPII vesicle coating
Golgi organization
protein localization to endoplasmic reticulum exit site

Displaying **all 3** entries
InterPro
Ancestral coatomer element 1, Sec16/Sec31
COPII coat assembly protein, Sec16
Sec16, central conserved domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32209		FB:FBgn0052654
Caenorhabditis elegans	176289		WB:WBGene00013985
Mus musculus	227648		MGI:2139207	MOUSE35607
Pan troglodytes	464863	9598_0:0029d4		PANTR45271
Bos taurus	519689			BOVIN03418
Danio rerio	567075		ZFIN:ZDB-GENE-130530-710
Canis lupus familiaris	607434			CANLF19265
Macaca mulatta	721736			MACMU12909
Xenopus laevis	734884		Xenbase:XB-GENE-986388
Saccharomyces cerevisiae S288C	856020		SGD:S000006006