GlyCosmos Portal

GlyCosmos Genes

Integrated list of glycan-related genes extracted KEGG GENES Database, UniProt, GlycoGene Database (GGDB), Plant GARDEN and FlyGlycoDB. Glycan-related genes including glycosyltransferase, hydrolase activity (acting on glycosyl bonds), carbohydrate metabolic process, etc .

Source	Last Updated
FlyGlycoDB	March 25, 2024
GlycoGene Database (GGDB)	January 26, 2018
KEGG GENES Database	September 20, 2023
Plant GARDEN	May 28, 2020
UniProt	October 29, 2024

Selecting the function you want to look up from the categories displays a list narrowed down to glycan-related genes with that function (Gene Ontology).

Catalytic activity

glycosyltransferase activity

hydrolase activity, acting on glycosyl bonds

Binding

carbohydrate binding

Response to carbohydrate

Primary metabolic process

Displaying entries **76 - 100** of **10109** in total

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Gene ID ▲	Gene Name	Gene Symbol	Organism	Taxonomy ID	Disease Ontology	Disease Ontology ID	Gene Ontology	Gene Ontology ID
128	alcohol dehydrogenase 5 (class III), chi polypeptide	ADH5 Aliases: ADH-3 ADHX GSNOR S-nitrosoglutathione reductase	Homo sapiens (human)	9606	AMED syndrome asthma	DOID:0080952 DOID:2841	S-(hydroxymethyl)glutathione dehydrogenase NAD activity S-(hydroxymethyl)glutathione dehydrogenase NADP activity S-(hydroxymethyl)glutathione dehydrogenase activity S-nitrosoglutathione reductase activity alcohol dehydrogenase (NAD+) activity alcohol dehydrogenase [NAD(P)+] activity aldehyde catabolic process aldehyde dehydrogenase (NAD+) activity aldehyde dehydrogenase [NAD(P)+] activity anion binding binding biological regulation biological_process carboxylic acid binding carboxylic acid metabolic process catabolic process catalytic activity cation binding cellular aldehyde metabolic process cellular anatomical entity cellular catabolic process cellular detoxification of aldehyde cellular detoxification cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytosol detoxification diterpenoid metabolic process electron transfer activity extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle fatty acid binding fatty acid metabolic process fatty acid omega-oxidation fatty acid oxidation formaldehyde catabolic process formaldehyde dehydrogenase activity formaldehyde metabolic process identical protein binding intracellular membrane-bounded organelle intracellular organelle ion binding isoprenoid metabolic process lipid binding lipid metabolic process lipid modification lipid oxidation membrane-bounded organelle metabolic process metal ion binding mitochondrion molecular_function monocarboxylic acid binding monocarboxylic acid metabolic process multicellular organismal process organelle organic acid binding organic acid metabolic process organic substance catabolic process organic substance metabolic process oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the aldehyde or oxo group of donors oxidoreductase activity oxoacid metabolic process positive regulation of blood pressure primary metabolic process protein binding regulation of biological quality regulation of blood pressure respiratory system process response to biotic stimulus response to chemical response to external biotic stimulus response to external stimulus response to lipid response to lipopolysaccharide response to molecule of bacterial origin response to nitrosative stress response to organic substance response to oxygen-containing compound response to redox state response to stimulus response to stress retinoid metabolic process small molecule binding small molecule catabolic process small molecule metabolic process system process terpenoid metabolic process transition metal ion binding vesicle zinc ion binding	GO:0001523 GO:0002237 GO:0003008 GO:0003016 GO:0003674 GO:0003824 GO:0004022 GO:0004029 GO:0004030 GO:0005488 GO:0005504 GO:0005515 GO:0005575 GO:0005739 GO:0005829 GO:0006081 GO:0006082 GO:0006629 GO:0006631 GO:0006720 GO:0006721 GO:0006950 GO:0008150 GO:0008152 GO:0008217 GO:0008270 GO:0008289 GO:0009055 GO:0009056 GO:0009605 GO:0009607 GO:0009987 GO:0010033 GO:0010430 GO:0016101 GO:0016491 GO:0016614 GO:0016616 GO:0016620 GO:0016903 GO:0018455 GO:0018467 GO:0019395 GO:0019752 GO:0030258 GO:0031406 GO:0031982 GO:0032496 GO:0032501 GO:0032787 GO:0033293 GO:0033993 GO:0034440 GO:0036094 GO:0042221 GO:0042802 GO:0043167 GO:0043168 GO:0043169 GO:0043177 GO:0043207 GO:0043226 GO:0043227 GO:0043229 GO:0043230 GO:0043231 GO:0043436 GO:0044237 GO:0044238 GO:0044248 GO:0044255 GO:0044281 GO:0044282 GO:0045777 GO:0046185 GO:0046292 GO:0046294 GO:0046872 GO:0046914 GO:0050896 GO:0051409 GO:0051775 GO:0051903 GO:0065007 GO:0065008 GO:0065010 GO:0070062 GO:0071704 GO:0080007 GO:0098754 GO:0106321 GO:0106322 GO:0110095 GO:0110165 GO:1901575 GO:1901700 GO:1903561 GO:1990748
130	alcohol dehydrogenase 6 (class V)	ADH6 Aliases: ADH-5	Homo sapiens (human)	9606			NAD-retinol dehydrogenase activity alcohol dehydrogenase (NAD+) activity alcohol dehydrogenase [NAD(P)+] activity alcohol metabolic process binding biological regulation biological_process carboxylic acid metabolic process catalytic activity cation binding cellular anatomical entity cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytosol diterpenoid metabolic process extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle hormone metabolic process ion binding isoprenoid metabolic process lipid metabolic process membrane-bounded organelle metabolic process metal ion binding molecular_function monocarboxylic acid metabolic process olefinic compound metabolic process organelle organic acid metabolic process organic hydroxy compound metabolic process organic substance metabolic process oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity oxoacid metabolic process primary alcohol metabolic process primary metabolic process regulation of biological quality regulation of hormone levels retinoic acid metabolic process retinoid metabolic process retinol metabolic process small molecule metabolic process terpenoid metabolic process transition metal ion binding vesicle zinc ion binding	GO:0001523 GO:0003674 GO:0003824 GO:0004022 GO:0004745 GO:0005488 GO:0005575 GO:0005829 GO:0006066 GO:0006082 GO:0006629 GO:0006720 GO:0006721 GO:0008150 GO:0008152 GO:0008270 GO:0009987 GO:0010817 GO:0016101 GO:0016491 GO:0016614 GO:0016616 GO:0018455 GO:0019752 GO:0031982 GO:0032787 GO:0034308 GO:0042445 GO:0042572 GO:0042573 GO:0043167 GO:0043169 GO:0043226 GO:0043227 GO:0043230 GO:0043436 GO:0044237 GO:0044238 GO:0044255 GO:0044281 GO:0046872 GO:0046914 GO:0065007 GO:0065008 GO:0065010 GO:0070062 GO:0071704 GO:0110165 GO:0120254 GO:1901615 GO:1903561
131	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	ADH7 Aliases: ADH-4	Homo sapiens (human)	9606			NAD-retinol dehydrogenase activity alcohol binding alcohol dehydrogenase (NAD+) activity alcohol dehydrogenase [NAD(P)+] activity alcohol metabolic process aldehyde oxidase activity binding biological process involved in interspecies interaction between organisms biological regulation biological_process carboxylic acid metabolic process catalytic activity cation binding cellular anatomical entity cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytosol diterpenoid metabolic process ethanol binding fatty acid metabolic process fatty acid omega-oxidation fatty acid oxidation hormone metabolic process ion binding isoprenoid binding isoprenoid metabolic process lipid binding lipid metabolic process lipid modification lipid oxidation membrane metabolic process metal ion binding molecular function inhibitor activity molecular function regulator activity molecular_function monocarboxylic acid metabolic process olefinic compound metabolic process omega-hydroxydecanoate dehydrogenase activity organic acid metabolic process organic hydroxy compound metabolic process organic substance metabolic process oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor oxidoreductase activity, acting on the aldehyde or oxo group of donors oxidoreductase activity oxoacid metabolic process plasma membrane primary alcohol metabolic process primary metabolic process protein binding receptor antagonist activity regulation of biological quality regulation of hormone levels response to alcohol response to bacterium response to biotic stimulus response to chemical response to ethanol response to external biotic stimulus response to external stimulus response to organic substance response to other organism response to oxygen-containing compound response to stimulus retinoic acid metabolic process retinoid binding retinoid metabolic process retinol binding retinol metabolic process signaling receptor binding signaling receptor inhibitor activity signaling receptor regulator activity small molecule binding small molecule metabolic process terpenoid metabolic process transition metal ion binding vitamin binding zinc ion binding	GO:0001523 GO:0003674 GO:0003824 GO:0004022 GO:0004031 GO:0004745 GO:0005102 GO:0005488 GO:0005501 GO:0005515 GO:0005575 GO:0005829 GO:0005886 GO:0006066 GO:0006082 GO:0006629 GO:0006631 GO:0006720 GO:0006721 GO:0008150 GO:0008152 GO:0008270 GO:0008289 GO:0009605 GO:0009607 GO:0009617 GO:0009987 GO:0010033 GO:0010430 GO:0010817 GO:0016020 GO:0016101 GO:0016491 GO:0016614 GO:0016616 GO:0016623 GO:0016903 GO:0018455 GO:0019395 GO:0019752 GO:0019840 GO:0019841 GO:0019842 GO:0030258 GO:0030545 GO:0030547 GO:0032787 GO:0034308 GO:0034440 GO:0035276 GO:0036094 GO:0042221 GO:0042445 GO:0042572 GO:0042573 GO:0043167 GO:0043169 GO:0043178 GO:0043207 GO:0043436 GO:0044237 GO:0044238 GO:0044255 GO:0044281 GO:0044419 GO:0045471 GO:0046872 GO:0046914 GO:0048019 GO:0050153 GO:0050896 GO:0051707 GO:0065007 GO:0065008 GO:0071704 GO:0097305 GO:0098772 GO:0110165 GO:0120254 GO:0140678 GO:1901615 GO:1901700
133	adrenomedullin	ADM	Homo sapiens (human)	9606	brain infarction breast cancer pancreatic cancer pulmonary hypertension	DOID:1612 DOID:1793 DOID:3454 DOID:6432	G protein-coupled receptor binding G protein-coupled receptor internalization G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenomedullin receptor binding adrenomedullin receptor signaling pathway anatomical structure development anatomical structure formation involved in morphogenesis anatomical structure morphogenesis androgen metabolic process animal organ development animal organ morphogenesis animal organ regeneration antibacterial humoral response antifungal humoral response antimicrobial humoral immune response mediated by antimicrobial peptide antimicrobial humoral response binding biological process involved in interspecies interaction between organisms biological regulation biological_process blood vessel diameter maintenance branching involved in labyrinthine layer morphogenesis cAMP-mediated signaling calcitonin family receptor signaling pathway cell development cell differentiation cell population proliferation cell projection organization cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular developmental process cellular process cellular response to chemical stimulus cellular response to stimulus cellular response to stress cellular response to xenobiotic stimulus cellular_component circulatory system process cyclic-nucleotide-mediated signaling cytoplasm cytoplasmic vesicle lumen defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to bacterium defense response to fungus defense response to other organism defense response developmental growth developmental process embryonic morphogenesis endocytosis establishment of localization extracellular region extracellular space female pregnancy growth heart development hormone activity hormone metabolic process humoral immune response immune response immune system process import into cell inflammatory response intracellular organelle lumen intracellular signal transduction lipid metabolic process localization membrane-enclosed lumen metabolic process molecular function activator activity molecular function regulator activity molecular_function morphogenesis of a branching epithelium morphogenesis of a branching structure morphogenesis of an epithelium multi-multicellular organism process multi-organism reproductive process multicellular organismal process muscle cell development negative regulation of biological process negative regulation of cell population proliferation negative regulation of cellular process negative regulation of multicellular organismal process negative regulation of vascular permeability negative regulation of vasoconstriction neural tube closure neuron projection development neuron projection regeneration odontogenesis of dentin-containing tooth odontogenesis organelle lumen organic cyclic compound metabolic process organic substance metabolic process plasma membrane bounded cell projection organization positive regulation of angiogenesis positive regulation of apoptotic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of blood circulation positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytosolic calcium ion concentration positive regulation of developmental process positive regulation of heart contraction positive regulation of heart rate positive regulation of hormone biosynthetic process positive regulation of hormone metabolic process positive regulation of lipid biosynthetic process positive regulation of lipid metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of progesterone biosynthetic process positive regulation of programmed cell death positive regulation of small molecule metabolic process positive regulation of steroid biosynthetic process positive regulation of steroid metabolic process positive regulation of vasculature development positive regulation of vasculogenesis primary metabolic process protein binding receptor internalization receptor ligand activity receptor-mediated endocytosis regeneration regulation of anatomical structure morphogenesis regulation of anatomical structure size regulation of angiogenesis regulation of apoptotic process regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of blood circulation regulation of blood pressure regulation of body fluid levels regulation of cell differentiation regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular ketone metabolic process regulation of cellular metabolic process regulation of cellular process regulation of developmental process regulation of heart contraction regulation of heart rate regulation of hormone biosynthetic process regulation of hormone levels regulation of hormone metabolic process regulation of ketone biosynthetic process regulation of lipid biosynthetic process regulation of lipid metabolic process regulation of metabolic process regulation of multicellular organismal development regulation of multicellular organismal process regulation of primary metabolic process regulation of progesterone biosynthetic process regulation of programmed cell death regulation of small molecule metabolic process regulation of steroid biosynthetic process regulation of steroid metabolic process regulation of system process regulation of systemic arterial blood pressure regulation of the force of heart contraction regulation of tube diameter regulation of tube size regulation of urine volume regulation of vascular permeability regulation of vasculature development regulation of vasculogenesis regulation of vasoconstriction renal system process reproductive process response to abiotic stimulus response to bacterium response to biotic stimulus response to chemical response to corticosteroid response to decreased oxygen levels response to endogenous stimulus response to ether response to external biotic stimulus response to external stimulus response to extracellular stimulus response to fungus response to glucocorticoid response to hormone response to hypoxia response to insulin response to lipid response to lipopolysaccharide response to molecule of bacterial origin response to nitrogen compound response to nutrient levels response to organic cyclic compound response to organic substance response to organonitrogen compound response to other organism response to oxygen levels response to oxygen-containing compound response to peptide hormone response to peptide response to starvation response to steroid hormone response to stimulus response to stress response to xenobiotic stimulus response to yeast second-messenger-mediated signaling secretory granule lumen signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity spongiotrophoblast layer development steroid metabolic process system process tissue development tissue morphogenesis transport tube closure tube formation vascular associated smooth muscle cell development vascular process in circulatory system vasculogenesis vesicle lumen vesicle-mediated transport	GO:0001570 GO:0001664 GO:0001666 GO:0001763 GO:0001843 GO:0001878 GO:0002009 GO:0002026 GO:0002027 GO:0002031 GO:0002237 GO:0002376 GO:0003008 GO:0003013 GO:0003014 GO:0003018 GO:0003073 GO:0003674 GO:0005102 GO:0005179 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0005737 GO:0006629 GO:0006810 GO:0006897 GO:0006898 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0006959 GO:0007165 GO:0007186 GO:0007188 GO:0007189 GO:0007204 GO:0007507 GO:0007565 GO:0008016 GO:0008150 GO:0008152 GO:0008202 GO:0008209 GO:0008217 GO:0008283 GO:0008284 GO:0008285 GO:0009410 GO:0009605 GO:0009607 GO:0009617 GO:0009620 GO:0009628 GO:0009653 GO:0009719 GO:0009725 GO:0009887 GO:0009888 GO:0009889 GO:0009891 GO:0009893 GO:0009987 GO:0009991 GO:0010033 GO:0010243 GO:0010460 GO:0010565 GO:0010566 GO:0010817 GO:0010893 GO:0014070 GO:0016043 GO:0016192 GO:0019216 GO:0019218 GO:0019222 GO:0019229 GO:0019730 GO:0019731 GO:0019732 GO:0019932 GO:0019933 GO:0019935 GO:0022414 GO:0022603 GO:0030030 GO:0030154 GO:0030545 GO:0030546 GO:0031099 GO:0031100 GO:0031102 GO:0031175 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031623 GO:0031667 GO:0031700 GO:0031960 GO:0031974 GO:0031983 GO:0032350 GO:0032352 GO:0032496 GO:0032501 GO:0032502 GO:0032868 GO:0033554 GO:0033993 GO:0034774 GO:0035148 GO:0035150 GO:0035296 GO:0035556 GO:0035809 GO:0036293 GO:0040007 GO:0042127 GO:0042221 GO:0042445 GO:0042475 GO:0042476 GO:0042594 GO:0042742 GO:0042981 GO:0043065 GO:0043067 GO:0043068 GO:0043114 GO:0043116 GO:0043207 GO:0043233 GO:0043434 GO:0044057 GO:0044238 GO:0044419 GO:0044703 GO:0044706 GO:0045472 GO:0045595 GO:0045597 GO:0045765 GO:0045766 GO:0045823 GO:0045834 GO:0045906 GO:0045940 GO:0046885 GO:0046886 GO:0046889 GO:0046890 GO:0048018 GO:0048468 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048545 GO:0048589 GO:0048598 GO:0048646 GO:0048729 GO:0048856 GO:0048869 GO:0050789 GO:0050793 GO:0050794 GO:0050810 GO:0050829 GO:0050830 GO:0050832 GO:0050878 GO:0050896 GO:0051094 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051384 GO:0051707 GO:0051716 GO:0055001 GO:0060205 GO:0060606 GO:0060670 GO:0060712 GO:0061138 GO:0061844 GO:0062012 GO:0062013 GO:0065007 GO:0065008 GO:0070013 GO:0070482 GO:0070887 GO:0071466 GO:0071704 GO:0071840 GO:0080090 GO:0090066 GO:0097084 GO:0097646 GO:0097746 GO:0098542 GO:0098657 GO:0098772 GO:0110165 GO:0120036 GO:0140677 GO:1901342 GO:1901360 GO:1901652 GO:1901698 GO:1901700 GO:1903522 GO:1903524 GO:1904018 GO:1990410 GO:2000026 GO:2000182 GO:2000184 GO:2001212 GO:2001214
134	adenosine A1 receptor	ADORA1	Homo sapiens (human)	9606	asthma	DOID:2841	G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor signaling pathway G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor activity G protein-coupled receptor binding G protein-coupled receptor signaling pathway G-protein beta/gamma-subunit complex binding acylglycerol homeostasis adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway anatomical structure development apoptotic signaling pathway asymmetric synapse axolemma axon terminus basolateral plasma membrane binding biological regulation biological_process blood vessel diameter maintenance body fluid secretion calcium ion homeostasis calyx of Held carbohydrate derivative binding catabolic process cell body cell communication cell junction cell migration cell motility cell projection membrane cell projection cell surface receptor signaling pathway cell-cell signaling cellular anatomical entity cellular homeostasis cellular localization cellular macromolecule localization cellular process cellular_component chemical homeostasis cilium circulatory system process cognition defense response dendrite dendritic spine detection of abiotic stimulus detection of external stimulus detection of stimulus involved in sensory perception of pain detection of stimulus involved in sensory perception detection of stimulus detection of temperature stimulus involved in sensory perception of pain detection of temperature stimulus involved in sensory perception detection of temperature stimulus developmental process endocytosis establishment of localization establishment of protein localization to membrane establishment of protein localization excitatory postsynaptic potential fatty acid homeostasis heat shock protein binding heterocyclic compound binding heterotrimeric G-protein binding homeostatic process immune system process import into cell inflammatory response inorganic ion homeostasis intracellular calcium ion homeostasis intracellular chemical homeostasis intracellular monoatomic cation homeostasis intracellular monoatomic ion homeostasis leading edge membrane leukocyte migration lipid catabolic process lipid homeostasis lipid metabolic process localization within membrane localization long-term synaptic depression macromolecule localization membrane-bounded organelle membrane metabolic process modulation of chemical synaptic transmission molecular transducer activity molecular_function monoatomic cation homeostasis monoatomic ion homeostasis mucus secretion multicellular organismal process multicellular organismal-level homeostasis negative regulation of acute inflammatory response negative regulation of amine transport negative regulation of amino acid transport negative regulation of apoptotic process negative regulation of behavior negative regulation of biological process negative regulation of blood pressure negative regulation of catabolic process negative regulation of cell communication negative regulation of cell migration negative regulation of cell motility negative regulation of cell population proliferation negative regulation of cellular process negative regulation of circadian rhythm negative regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of circadian sleep/wake cycle, sleep negative regulation of defense response negative regulation of glutamate secretion negative regulation of hormone secretion negative regulation of immune system process negative regulation of inflammatory response negative regulation of leukocyte migration negative regulation of lipid catabolic process negative regulation of lipid metabolic process negative regulation of locomotion negative regulation of long-term synaptic depression negative regulation of long-term synaptic potentiation negative regulation of metabolic process negative regulation of mucus secretion negative regulation of multicellular organismal process negative regulation of neurotrophin production negative regulation of organic acid transport negative regulation of programmed cell death negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of secretion by cell negative regulation of secretion negative regulation of signaling negative regulation of synaptic transmission, GABAergic negative regulation of synaptic transmission, glutamatergic negative regulation of synaptic transmission negative regulation of systemic arterial blood pressure negative regulation of transport nervous system development nervous system process neuron cellular homeostasis neuron projection membrane neuron projection terminus neuron projection neuron spine neuron to neuron synapse neuronal cell body nucleoside binding organelle organic cyclic compound binding organic substance catabolic process organic substance metabolic process phagocytosis plasma membrane bounded cell projection plasma membrane region plasma membrane positive regulation of MAPK cascade positive regulation of biological process positive regulation of blood pressure positive regulation of catabolic process positive regulation of cell communication positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of dephosphorylation positive regulation of intracellular signal transduction positive regulation of lipid catabolic process positive regulation of lipid metabolic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of monoatomic ion transport positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound transport positive regulation of nucleoside transport positive regulation of peptide secretion positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of potassium ion transport positive regulation of protein dephosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of response to stimulus positive regulation of secretion positive regulation of signal transduction positive regulation of signaling positive regulation of synaptic transmission positive regulation of systemic arterial blood pressure positive regulation of transport postsynapse postsynaptic membrane presynapse presynaptic active zone presynaptic membrane primary metabolic process protein binding protein dimerization activity protein heterodimerization activity protein localization to membrane protein localization protein targeting to membrane protein targeting protein-containing complex binding purine nucleoside binding purinergic nucleotide receptor signaling pathway regulation of MAPK cascade regulation of actin filament-based movement regulation of actin filament-based process regulation of acute inflammatory response regulation of amine transport regulation of amino acid transport regulation of anatomical structure size regulation of apoptotic process regulation of behavior regulation of biological process regulation of biological quality regulation of blood circulation regulation of blood pressure regulation of body fluid levels regulation of cardiac muscle cell contraction regulation of cardiac muscle contraction regulation of catabolic process regulation of cell communication regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cellular metabolic process regulation of cellular process regulation of circadian rhythm regulation of circadian sleep/wake cycle, non-REM sleep regulation of circadian sleep/wake cycle, sleep regulation of circadian sleep/wake cycle regulation of cytosolic calcium ion concentration regulation of defense response regulation of dephosphorylation regulation of glomerular filtration regulation of glutamate secretion regulation of heart contraction regulation of hormone levels regulation of hormone secretion regulation of immune system process regulation of inflammatory response regulation of intracellular signal transduction regulation of leukocyte migration regulation of lipid catabolic process regulation of lipid metabolic process regulation of localization regulation of locomotion regulation of long-term synaptic depression regulation of long-term synaptic potentiation regulation of macromolecule metabolic process regulation of membrane potential regulation of metabolic process regulation of metal ion transport regulation of monoatomic ion transport regulation of mucus secretion regulation of multicellular organismal process regulation of muscle contraction regulation of muscle system process regulation of nervous system process regulation of neurotrophin production regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound transport regulation of nucleoside transport regulation of organic acid transport regulation of peptide secretion regulation of peptide transport regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of postsynaptic membrane potential regulation of potassium ion transport regulation of presynaptic cytosolic calcium ion concentration regulation of primary metabolic process regulation of programmed cell death regulation of protein dephosphorylation regulation of protein metabolic process regulation of protein modification process regulation of renal system process regulation of respiratory gaseous exchange by nervous system process regulation of respiratory gaseous exchange regulation of respiratory system process regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of secretion by cell regulation of secretion regulation of sensory perception of pain regulation of sensory perception regulation of signal transduction regulation of signaling regulation of striated muscle contraction regulation of synaptic plasticity regulation of synaptic transmission, GABAergic regulation of synaptic transmission, glutamatergic regulation of system process regulation of trans-synaptic signaling regulation of transport regulation of tube diameter regulation of tube size renal system process involved in regulation of blood volume renal system process involved in regulation of systemic arterial blood pressure renal system process response to abiotic stimulus response to chemical response to decreased oxygen levels response to external stimulus response to hypoxia response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to oxygen levels response to purine-containing compound response to stimulus response to stress response to temperature stimulus secretion by tissue secretion signal transduction signaling receptor activity signaling receptor binding signaling small molecule binding synapse synaptic membrane system development system process temperature homeostasis terminal bouton transmembrane signaling receptor activity transport triglyceride homeostasis vascular process in circulatory system vasodilation vesicle-mediated transport	GO:0001609 GO:0001659 GO:0001664 GO:0001666 GO:0001882 GO:0001883 GO:0001973 GO:0001977 GO:0002087 GO:0002376 GO:0002673 GO:0002674 GO:0002682 GO:0002683 GO:0002685 GO:0002686 GO:0002791 GO:0002793 GO:0003008 GO:0003013 GO:0003014 GO:0003018 GO:0003071 GO:0003084 GO:0003085 GO:0003093 GO:0003674 GO:0004888 GO:0004930 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0005929 GO:0006605 GO:0006612 GO:0006629 GO:0006810 GO:0006873 GO:0006874 GO:0006897 GO:0006909 GO:0006937 GO:0006942 GO:0006950 GO:0006952 GO:0006954 GO:0007154 GO:0007165 GO:0007166 GO:0007186 GO:0007188 GO:0007193 GO:0007267 GO:0007399 GO:0007589 GO:0008016 GO:0008104 GO:0008150 GO:0008152 GO:0008217 GO:0008285 GO:0009056 GO:0009266 GO:0009581 GO:0009582 GO:0009605 GO:0009628 GO:0009892 GO:0009893 GO:0009894 GO:0009895 GO:0009896 GO:0009966 GO:0009967 GO:0009987 GO:0010033 GO:0010243 GO:0010562 GO:0010604 GO:0010646 GO:0010647 GO:0010648 GO:0010817 GO:0010959 GO:0014048 GO:0014050 GO:0014070 GO:0014074 GO:0016020 GO:0016042 GO:0016048 GO:0016192 GO:0016323 GO:0016477 GO:0019216 GO:0019220 GO:0019222 GO:0019725 GO:0023051 GO:0023052 GO:0023056 GO:0023057 GO:0030003 GO:0030054 GO:0030334 GO:0030336 GO:0030425 GO:0030673 GO:0031072 GO:0031253 GO:0031256 GO:0031323 GO:0031325 GO:0031347 GO:0031348 GO:0031399 GO:0031401 GO:0031644 GO:0031683 GO:0032101 GO:0032102 GO:0032228 GO:0032229 GO:0032239 GO:0032241 GO:0032242 GO:0032244 GO:0032279 GO:0032501 GO:0032502 GO:0032589 GO:0032795 GO:0032879 GO:0032890 GO:0032891 GO:0032899 GO:0032900 GO:0032941 GO:0032970 GO:0033036 GO:0035150 GO:0035296 GO:0035303 GO:0035304 GO:0035306 GO:0035307 GO:0035588 GO:0035590 GO:0036094 GO:0036293 GO:0038023 GO:0040012 GO:0040013 GO:0042127 GO:0042221 GO:0042311 GO:0042321 GO:0042323 GO:0042391 GO:0042592 GO:0042734 GO:0042749 GO:0042752 GO:0042754 GO:0042981 GO:0042995 GO:0043005 GO:0043025 GO:0043066 GO:0043067 GO:0043069 GO:0043195 GO:0043197 GO:0043226 GO:0043227 GO:0043266 GO:0043268 GO:0043269 GO:0043270 GO:0043408 GO:0043410 GO:0043576 GO:0043679 GO:0044057 GO:0044065 GO:0044238 GO:0044297 GO:0044305 GO:0044306 GO:0044309 GO:0044877 GO:0045184 GO:0045187 GO:0045188 GO:0045202 GO:0045211 GO:0045776 GO:0045777 GO:0045833 GO:0045834 GO:0045937 GO:0046883 GO:0046888 GO:0046903 GO:0046982 GO:0046983 GO:0048167 GO:0048518 GO:0048519 GO:0048521 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048731 GO:0048786 GO:0048856 GO:0048870 GO:0048871 GO:0048878 GO:0050727 GO:0050728 GO:0050789 GO:0050794 GO:0050795 GO:0050801 GO:0050804 GO:0050805 GO:0050806 GO:0050877 GO:0050878 GO:0050890 GO:0050896 GO:0050900 GO:0050906 GO:0050961 GO:0050965 GO:0050994 GO:0050995 GO:0050996 GO:0051046 GO:0051047 GO:0051048 GO:0051049 GO:0051050 GO:0051051 GO:0051171 GO:0051173 GO:0051174 GO:0051179 GO:0051234 GO:0051239 GO:0051241 GO:0051246 GO:0051247 GO:0051480 GO:0051606 GO:0051641 GO:0051668 GO:0051930 GO:0051931 GO:0051952 GO:0051953 GO:0051955 GO:0051956 GO:0051966 GO:0051967 GO:0055074 GO:0055080 GO:0055082 GO:0055088 GO:0055089 GO:0055090 GO:0055117 GO:0060078 GO:0060079 GO:0060089 GO:0060255 GO:0060292 GO:0062149 GO:0065007 GO:0065008 GO:0070050 GO:0070254 GO:0070255 GO:0070256 GO:0070328 GO:0070482 GO:0070727 GO:0071704 GO:0072657 GO:0080090 GO:0080134 GO:0086004 GO:0090066 GO:0090087 GO:0090150 GO:0090257 GO:0097060 GO:0097159 GO:0097190 GO:0097367 GO:0097746 GO:0098590 GO:0098657 GO:0098771 GO:0098793 GO:0098794 GO:0098801 GO:0098984 GO:0099177 GO:0099509 GO:0110165 GO:0120025 GO:1900271 GO:1900272 GO:1900452 GO:1900453 GO:1901363 GO:1901575 GO:1901698 GO:1902531 GO:1902533 GO:1903115 GO:1903522 GO:1903530 GO:1903531 GO:2000145 GO:2000146
135	adenosine A2a receptor	ADORA2A	Homo sapiens (human)	9606	asthma	DOID:2841	G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor signaling pathway G protein-coupled glutamate receptor binding G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor activity G protein-coupled receptor binding G protein-coupled receptor signaling pathway actinin binding adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway alpha-actinin binding anatomical structure development anatomical structure morphogenesis anterograde trans-synaptic signaling apoptotic process apoptotic signaling pathway astrocyte activation asymmetric synapse axolemma behavior binding biological regulation biological_process blood circulation blood coagulation blood vessel diameter maintenance calmodulin binding cell activation cell body cell communication cell death cell junction cell projection membrane cell projection morphogenesis cell projection organization cell projection cell surface receptor signaling pathway cell-cell signaling cellular anatomical entity morphogenesis cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular defense response cellular process cellular_component central nervous system development chemical synaptic transmission circulatory system process coagulation cytoskeletal protein binding defense response dendrite developmental process eating behavior endocytosis enzyme binding establishment of localization excitatory postsynaptic potential feeding behavior glial cell activation glutamate receptor binding glutamatergic synapse hemostasis identical protein binding import into cell inflammatory response inhibitory postsynaptic potential intermediate filament leading edge membrane lipid binding localization locomotory behavior membrane depolarization membrane modulation of chemical synaptic transmission molecular transducer activity molecular_function multicellular organismal process negative regulation of T cell activation negative regulation of alpha-beta T cell activation negative regulation of apoptotic process negative regulation of biological process negative regulation of cell activation negative regulation of cell adhesion negative regulation of cell population proliferation negative regulation of cell-cell adhesion negative regulation of cellular process negative regulation of defense response negative regulation of immune system process negative regulation of inflammatory response negative regulation of leukocyte activation negative regulation of leukocyte cell-cell adhesion negative regulation of lymphocyte activation negative regulation of multicellular organismal process negative regulation of neuron apoptotic process negative regulation of programmed cell death negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of vascular permeability nervous system process neuron projection membrane neuron projection morphogenesis neuron projection neuron to neuron synapse neuronal cell body phagocytosis phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane bounded cell projection morphogenesis plasma membrane bounded cell projection plasma membrane region plasma membrane polymeric cytoskeletal fiber positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade positive regulation of acetylcholine secretion, neurotransmission positive regulation of amine transport positive regulation of amino acid transport positive regulation of apoptotic process positive regulation of apoptotic signaling pathway positive regulation of behavior positive regulation of biological process positive regulation of cell communication positive regulation of cellular process positive regulation of circadian rhythm positive regulation of circadian sleep/wake cycle, sleep positive regulation of establishment of protein localization positive regulation of glutamate secretion positive regulation of intracellular signal transduction positive regulation of long-term synaptic potentiation positive regulation of multicellular organismal process positive regulation of neurotransmitter secretion positive regulation of neurotransmitter transport positive regulation of organic acid transport positive regulation of programmed cell death positive regulation of protein localization positive regulation of protein secretion positive regulation of protein transport positive regulation of response to stimulus positive regulation of secretion by cell positive regulation of secretion positive regulation of signal transduction positive regulation of signaling positive regulation of synaptic transmission, GABAergic positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, glutamatergic positive regulation of synaptic transmission positive regulation of transport positive regulation of urine volume postsynaptic membrane prepulse inhibition presynaptic active zone presynaptic membrane presynaptic modulation of chemical synaptic transmission programmed cell death protein binding protein-containing complex binding purinergic nucleotide receptor signaling pathway regulation of DNA-templated transcription regulation of ERK1 and ERK2 cascade regulation of MAPK cascade regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of T cell activation regulation of acetylcholine secretion, neurotransmission regulation of alpha-beta T cell activation regulation of amine transport regulation of amino acid transport regulation of anatomical structure size regulation of apoptotic process regulation of apoptotic signaling pathway regulation of behavior regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of body fluid levels regulation of calcium ion transport regulation of catecholamine secretion regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular localization regulation of cellular metabolic process regulation of cellular process regulation of circadian rhythm regulation of circadian sleep/wake cycle, sleep regulation of circadian sleep/wake cycle regulation of defense response regulation of establishment of protein localization regulation of gene expression regulation of glutamate secretion regulation of immune system process regulation of inflammatory response regulation of intracellular signal transduction regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of localization regulation of long-term synaptic potentiation regulation of lymphocyte activation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of membrane potential regulation of metabolic process regulation of metal ion transport regulation of mitochondrial membrane potential regulation of monoatomic ion transport regulation of multicellular organismal process regulation of neuron apoptotic process regulation of neurotransmitter secretion regulation of neurotransmitter transport regulation of nitrogen compound metabolic process regulation of norepinephrine secretion regulation of nucleobase-containing compound metabolic process regulation of organic acid transport regulation of postsynaptic membrane potential regulation of primary metabolic process regulation of programmed cell death regulation of protein localization regulation of protein secretion regulation of protein transport regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling regulation of synaptic plasticity regulation of synaptic transmission, GABAergic regulation of synaptic transmission, cholinergic regulation of synaptic transmission, glutamatergic regulation of trans-synaptic signaling regulation of transport regulation of tube diameter regulation of tube size regulation of urine volume regulation of vascular permeability renal system process response to alkaloid response to amine response to amphetamine response to caffeine response to chemical response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to purine-containing compound response to stimulus response to stress response to xenobiotic stimulus sensory perception signal transduction signaling receptor activity signaling receptor binding signaling supramolecular complex supramolecular fiber supramolecular polymer synapse synaptic membrane synaptic signaling synaptic transmission, cholinergic synaptic transmission, dopaminergic synaptic transmission, glutamatergic system development system process trans-synaptic signaling transmembrane signaling receptor activity transport type 5 metabotropic glutamate receptor binding vascular process in circulatory system vasodilation vesicle-mediated transport	GO:0001609 GO:0001664 GO:0001775 GO:0001956 GO:0001963 GO:0001973 GO:0001975 GO:0002682 GO:0002683 GO:0002694 GO:0002695 GO:0003008 GO:0003013 GO:0003014 GO:0003018 GO:0003674 GO:0004888 GO:0004930 GO:0005102 GO:0005488 GO:0005515 GO:0005516 GO:0005575 GO:0005882 GO:0005886 GO:0006355 GO:0006810 GO:0006897 GO:0006909 GO:0006915 GO:0006950 GO:0006952 GO:0006954 GO:0006968 GO:0007154 GO:0007162 GO:0007165 GO:0007166 GO:0007186 GO:0007188 GO:0007189 GO:0007200 GO:0007267 GO:0007268 GO:0007271 GO:0007417 GO:0007596 GO:0007599 GO:0007600 GO:0007610 GO:0007626 GO:0007631 GO:0008015 GO:0008092 GO:0008150 GO:0008219 GO:0008285 GO:0008289 GO:0009410 GO:0009653 GO:0009889 GO:0009966 GO:0009967 GO:0009987 GO:0010033 GO:0010243 GO:0010468 GO:0010556 GO:0010646 GO:0010647 GO:0010959 GO:0012501 GO:0014048 GO:0014049 GO:0014056 GO:0014057 GO:0014061 GO:0014070 GO:0014074 GO:0014075 GO:0016020 GO:0016043 GO:0016192 GO:0019219 GO:0019222 GO:0019899 GO:0022407 GO:0022408 GO:0023051 GO:0023052 GO:0023056 GO:0030030 GO:0030054 GO:0030155 GO:0030425 GO:0030673 GO:0031000 GO:0031253 GO:0031256 GO:0031323 GO:0031326 GO:0031347 GO:0031348 GO:0031802 GO:0032101 GO:0032102 GO:0032222 GO:0032224 GO:0032228 GO:0032230 GO:0032279 GO:0032501 GO:0032502 GO:0032589 GO:0032879 GO:0032880 GO:0032890 GO:0032892 GO:0032989 GO:0035150 GO:0035249 GO:0035254 GO:0035256 GO:0035296 GO:0035588 GO:0035590 GO:0035809 GO:0035810 GO:0038023 GO:0042127 GO:0042221 GO:0042311 GO:0042391 GO:0042734 GO:0042749 GO:0042752 GO:0042753 GO:0042755 GO:0042802 GO:0042805 GO:0042981 GO:0042995 GO:0043005 GO:0043025 GO:0043065 GO:0043066 GO:0043067 GO:0043068 GO:0043069 GO:0043114 GO:0043116 GO:0043269 GO:0043279 GO:0043408 GO:0043410 GO:0043523 GO:0043524 GO:0044297 GO:0044877 GO:0045187 GO:0045202 GO:0045211 GO:0045938 GO:0046634 GO:0046636 GO:0046928 GO:0048143 GO:0048167 GO:0048518 GO:0048519 GO:0048520 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048731 GO:0048786 GO:0048812 GO:0048856 GO:0048858 GO:0050433 GO:0050708 GO:0050714 GO:0050727 GO:0050728 GO:0050789 GO:0050794 GO:0050795 GO:0050804 GO:0050806 GO:0050817 GO:0050863 GO:0050865 GO:0050866 GO:0050868 GO:0050877 GO:0050878 GO:0050896 GO:0051046 GO:0051047 GO:0051049 GO:0051050 GO:0051171 GO:0051179 GO:0051222 GO:0051223 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051249 GO:0051250 GO:0051252 GO:0051393 GO:0051588 GO:0051590 GO:0051881 GO:0051899 GO:0051924 GO:0051952 GO:0051954 GO:0051955 GO:0051957 GO:0051966 GO:0051968 GO:0060078 GO:0060079 GO:0060080 GO:0060089 GO:0060134 GO:0060255 GO:0060341 GO:0061900 GO:0065007 GO:0065008 GO:0070201 GO:0070372 GO:0070374 GO:0071840 GO:0080090 GO:0080134 GO:0090066 GO:0097060 GO:0097190 GO:0097746 GO:0098590 GO:0098657 GO:0098916 GO:0098978 GO:0098984 GO:0099080 GO:0099081 GO:0099171 GO:0099177 GO:0099512 GO:0099513 GO:0099536 GO:0099537 GO:0110165 GO:0120025 GO:0120039 GO:1900271 GO:1900273 GO:1901698 GO:1902531 GO:1902533 GO:1903037 GO:1903038 GO:1903530 GO:1903532 GO:1903829 GO:1904951 GO:2001141 GO:2001233 GO:2001235
136	adenosine A2b receptor	ADORA2B	Homo sapiens (human)	9606			G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor signaling pathway G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor activity G protein-coupled receptor signaling pathway Schaffer collateral - CA1 synapse activation of adenylate cyclase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway binding biological regulation biological_process blood vessel diameter maintenance cGMP-mediated signaling cell junction cell surface receptor signaling pathway cellular anatomical entity cellular process cellular_component circulatory system process cyclic-nucleotide-mediated signaling establishment of localization in cell establishment of localization establishment of organelle localization exocytosis export from cell glutamatergic synapse immune effector process immune system process intracellular signal transduction leukocyte degranulation localization lysosome localization mast cell degranulation membrane modulation of chemical synaptic transmission molecular transducer activity molecular_function multicellular organismal process muscle system process negative regulation of biological process negative regulation of multicellular organismal process negative regulation of muscle contraction negative regulation of smooth muscle contraction organelle localization plasma membrane positive regulation of adenylate cyclase activity positive regulation of biological process positive regulation of biosynthetic process positive regulation of cGMP-mediated signaling positive regulation of catalytic activity positive regulation of cell communication positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of chemokine production positive regulation of chronic inflammatory response to non-antigenic stimulus positive regulation of chronic inflammatory response positive regulation of cyclase activity positive regulation of cytokine production positive regulation of defense response positive regulation of exocytosis positive regulation of gene expression positive regulation of immune effector process positive regulation of immune system process positive regulation of inflammatory response positive regulation of interleukin-6 production positive regulation of intracellular signal transduction positive regulation of leukocyte degranulation positive regulation of lyase activity positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of mast cell degranulation positive regulation of metabolic process positive regulation of molecular function positive regulation of multicellular organismal process positive regulation of regulated secretory pathway positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of secretion by cell positive regulation of secretion positive regulation of signal transduction positive regulation of signaling positive regulation of transport positive regulation of vascular endothelial growth factor production presynapse presynaptic modulation of chemical synaptic transmission protein binding purinergic nucleotide receptor signaling pathway regulated exocytosis regulation of adenylate cyclase activity regulation of anatomical structure size regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of cGMP-mediated signaling regulation of catalytic activity regulation of cell communication regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of chemokine production regulation of chronic inflammatory response to non-antigenic stimulus regulation of chronic inflammatory response regulation of cyclase activity regulation of cytokine production regulation of defense response regulation of exocytosis regulation of gene expression regulation of immune effector process regulation of immune system process regulation of inflammatory response regulation of interleukin-6 production regulation of intracellular signal transduction regulation of leukocyte degranulation regulation of leukocyte mediated immunity regulation of localization regulation of lyase activity regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of mast cell degranulation regulation of metabolic process regulation of molecular function regulation of multicellular organismal process regulation of muscle contraction regulation of muscle system process regulation of myeloid leukocyte mediated immunity regulation of regulated secretory pathway regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling regulation of smooth muscle contraction regulation of system process regulation of trans-synaptic signaling regulation of transport regulation of tube diameter regulation of tube size regulation of vascular endothelial growth factor production regulation of vesicle-mediated transport relaxation of muscle relaxation of smooth muscle relaxation of vascular associated smooth muscle second-messenger-mediated signaling secretion by cell secretion signal transduction signaling receptor activity synapse system process transmembrane signaling receptor activity transport vacuolar localization vascular process in circulatory system vasodilation vesicle-mediated transport	GO:0001609 GO:0001817 GO:0001819 GO:0001973 GO:0002252 GO:0002376 GO:0002676 GO:0002678 GO:0002682 GO:0002684 GO:0002697 GO:0002699 GO:0002703 GO:0002880 GO:0002882 GO:0002886 GO:0003008 GO:0003012 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0004930 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0006810 GO:0006887 GO:0006937 GO:0006940 GO:0007165 GO:0007166 GO:0007186 GO:0007188 GO:0007189 GO:0007190 GO:0008150 GO:0009889 GO:0009891 GO:0009893 GO:0009966 GO:0009967 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010574 GO:0010575 GO:0010604 GO:0010628 GO:0010646 GO:0010647 GO:0010752 GO:0010753 GO:0016020 GO:0016192 GO:0017157 GO:0019222 GO:0019932 GO:0019934 GO:0019935 GO:0023051 GO:0023056 GO:0030054 GO:0031279 GO:0031281 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031347 GO:0031349 GO:0032101 GO:0032103 GO:0032418 GO:0032501 GO:0032642 GO:0032675 GO:0032722 GO:0032755 GO:0032879 GO:0032940 GO:0035150 GO:0035296 GO:0035556 GO:0035588 GO:0035590 GO:0038023 GO:0042311 GO:0043085 GO:0043299 GO:0043300 GO:0043302 GO:0043303 GO:0043304 GO:0043306 GO:0044057 GO:0044093 GO:0044557 GO:0045055 GO:0045202 GO:0045761 GO:0045762 GO:0045921 GO:0045932 GO:0045986 GO:0046903 GO:0048518 GO:0048519 GO:0048522 GO:0048583 GO:0048584 GO:0050727 GO:0050729 GO:0050789 GO:0050790 GO:0050794 GO:0050804 GO:0051046 GO:0051047 GO:0051049 GO:0051050 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051339 GO:0051349 GO:0051640 GO:0051649 GO:0051656 GO:0060087 GO:0060089 GO:0060255 GO:0060627 GO:0065007 GO:0065008 GO:0065009 GO:0080134 GO:0090066 GO:0090075 GO:0090257 GO:0097746 GO:0098685 GO:0098793 GO:0098978 GO:0099171 GO:0099177 GO:0110165 GO:0140352 GO:1902531 GO:1902533 GO:1903305 GO:1903307 GO:1903530 GO:1903532 GO:1990849
140	adenosine A3 receptor	ADORA3	Homo sapiens (human)	9606			G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor signaling pathway G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor activity G protein-coupled receptor signaling pathway Schaffer collateral - CA1 synapse activation of adenylate cyclase activity biological regulation biological_process cell junction cell projection cell surface receptor signaling pathway cellular anatomical entity cellular process cellular_component defense response dendrite inflammatory response membrane modulation of chemical synaptic transmission molecular transducer activity molecular_function negative regulation of DNA-binding transcription factor activity negative regulation of NF-kappaB transcription factor activity negative regulation of biological process negative regulation of cell migration negative regulation of cell motility negative regulation of cell population proliferation negative regulation of cellular process negative regulation of locomotion negative regulation of molecular function neuron projection plasma membrane bounded cell projection plasma membrane region plasma membrane positive regulation of adenylate cyclase activity positive regulation of catalytic activity positive regulation of cyclase activity positive regulation of lyase activity positive regulation of molecular function presynaptic membrane presynaptic modulation of chemical synaptic transmission purinergic nucleotide receptor signaling pathway regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of adenylate cyclase activity regulation of amine transport regulation of biological process regulation of biosynthetic process regulation of blood circulation regulation of catalytic activity regulation of catecholamine secretion regulation of cell communication regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cyclase activity regulation of gene expression regulation of heart contraction regulation of localization regulation of locomotion regulation of lyase activity regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of norepinephrine secretion regulation of nucleobase-containing compound metabolic process regulation of primary metabolic process regulation of secretion by cell regulation of secretion regulation of signaling regulation of system process regulation of trans-synaptic signaling regulation of transport response to stimulus response to stress response to wounding signal transduction signaling receptor activity synapse synaptic membrane transmembrane signaling receptor activity	GO:0001609 GO:0001973 GO:0003674 GO:0004888 GO:0004930 GO:0005575 GO:0005886 GO:0006355 GO:0006950 GO:0006952 GO:0006954 GO:0007165 GO:0007166 GO:0007186 GO:0007190 GO:0008016 GO:0008150 GO:0008285 GO:0009611 GO:0009889 GO:0009987 GO:0010468 GO:0010556 GO:0010646 GO:0014061 GO:0016020 GO:0019219 GO:0019222 GO:0023051 GO:0030054 GO:0030334 GO:0030336 GO:0030425 GO:0031279 GO:0031281 GO:0031323 GO:0031326 GO:0032088 GO:0032879 GO:0035588 GO:0035590 GO:0038023 GO:0040012 GO:0040013 GO:0042127 GO:0042734 GO:0042995 GO:0043005 GO:0043085 GO:0043433 GO:0044057 GO:0044092 GO:0044093 GO:0045202 GO:0045761 GO:0045762 GO:0048519 GO:0048523 GO:0050433 GO:0050789 GO:0050790 GO:0050794 GO:0050804 GO:0050896 GO:0051046 GO:0051049 GO:0051090 GO:0051171 GO:0051239 GO:0051252 GO:0051339 GO:0051349 GO:0051952 GO:0060089 GO:0060255 GO:0065007 GO:0065009 GO:0080090 GO:0097060 GO:0098590 GO:0098685 GO:0099171 GO:0099177 GO:0110165 GO:0120025 GO:1903522 GO:1903530 GO:2000145 GO:2000146 GO:2001141
141	ADP-ribosylarginine hydrolase	ADPRH Aliases: ARH1 [Protein ADP-ribosylarginine] hydrolase	Homo sapiens (human)	9606			ADP-ribosylarginine hydrolase activity alkali metal ion binding binding biological_process catalytic activity, acting on a protein catalytic activity cation binding cellular anatomical entity cellular_component extracellular space hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds hydrolase activity ion binding macromolecule metabolic process macromolecule modification magnesium ion binding metabolic process metal ion binding molecular_function nitrogen compound metabolic process organic substance metabolic process organonitrogen compound metabolic process potassium ion binding primary metabolic process protein binding protein de-ADP-ribosylation protein metabolic process protein modification process	GO:0000287 GO:0003674 GO:0003824 GO:0003875 GO:0005488 GO:0005515 GO:0005575 GO:0005615 GO:0006807 GO:0008150 GO:0008152 GO:0016787 GO:0016798 GO:0016799 GO:0019538 GO:0030955 GO:0031420 GO:0036211 GO:0043167 GO:0043169 GO:0043170 GO:0043412 GO:0044238 GO:0046872 GO:0051725 GO:0071704 GO:0110165 GO:0140096 GO:1901564
142	poly(ADP-ribose) polymerase 1	PARP1 Aliases: ARTD1 PARP PARS Poly-PARP	Homo sapiens (human)	9606	Alzheimer's disease Parkinson's disease arthritis asthma autoimmune disease bacterial meningitis nephritis stomach carcinoma	DOID:10652 DOID:10952 DOID:14330 DOID:2841 DOID:417 DOID:5517 DOID:848 DOID:9470	ATP generation from poly-ADP-D-ribose ATP metabolic process DNA ADP-ribosylation DNA binding DNA damage response DNA metabolic process DNA modification DNA repair DNA-binding transcription factor binding DNA-templated DNA replication maintenance of fidelity DNA-templated transcription NAD DNA ADP-ribosyltransferase activity NAD binding NAD+ ADP-ribosyltransferase activity NAD+- protein-aspartate ADP-ribosyltransferase activity NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity NAD+-histone H2BS6 serine ADP-ribosyltransferase activity NAD+-histone H3S10 serine ADP-ribosyltransferase activity NAD+-protein ADP-ribosyltransferase activity NAD+-protein-glutamate ADP-ribosyltransferase activity NAD+-protein-histidine ADP-ribosyltransferase activity NAD+-protein-serine ADP-ribosyltransferase activity NAD+-protein-tyrosine ADP-ribosyltransferase activity R-SMAD binding RNA binding RNA biosynthetic process RNA metabolic process RNA polymerase II-specific DNA-binding transcription factor binding SMAD binding adenyl nucleotide binding anatomical structure development apoptotic process aromatic compound biosynthetic process binding biological process involved in interspecies interaction between organisms biological regulation biological_process biosynthetic process carbohydrate biosynthetic process carbohydrate derivative metabolic process carbohydrate metabolic process catalytic activity, acting on a protein catalytic activity cation binding cell death cell differentiation cell surface receptor signaling pathway cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular component organization or biogenesis cellular component organization cellular developmental process cellular localization cellular macromolecule localization cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular response to UV cellular response to abiotic stimulus cellular response to amyloid-beta cellular response to chemical stimulus cellular response to chemical stress cellular response to endogenous stimulus cellular response to environmental stimulus cellular response to growth factor stimulus cellular response to hormone stimulus cellular response to inorganic substance cellular response to insulin stimulus cellular response to light stimulus cellular response to metal ion cellular response to nerve growth factor stimulus cellular response to nitrogen compound cellular response to organic substance cellular response to organonitrogen compound cellular response to oxidative stress cellular response to oxygen-containing compound cellular response to peptide hormone stimulus cellular response to peptide cellular response to radiation cellular response to stimulus cellular response to stress cellular response to zinc ion cellular_component chromatin binding chromatin chromosomal region chromosome organization chromosome, telomeric region cytosol damaged DNA binding decidualization defense response to other organism defense response developmental process involved in reproduction developmental process double-strand break repair envelope enzyme activator activity enzyme binding enzyme regulator activity enzyme-linked receptor protein signaling pathway glycosyltransferase activity heterocycle biosynthetic process heterocycle metabolic process heterocyclic compound binding histone deacetylase binding identical protein binding immune response immune system process innate immune response intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle ion binding kinase binding leukocyte differentiation localization macromolecule biosynthetic process macromolecule localization macromolecule metabolic process macromolecule modification macrophage differentiation membrane-bounded organelle membrane metabolic process metal ion binding mitochondrial DNA metabolic process mitochondrial DNA repair mitochondrion organization mitochondrion molecular function activator activity molecular function regulator activity molecular_function myeloid cell differentiation myeloid leukocyte differentiation negative regulation of ATP biosynthetic process negative regulation of ATP metabolic process negative regulation of DNA metabolic process negative regulation of DNA-templated transcription, elongation negative regulation of DNA-templated transcription negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of adipose tissue development negative regulation of biological process negative regulation of biosynthetic process negative regulation of cGAS/STING signaling pathway negative regulation of cell communication negative regulation of cellular biosynthetic process negative regulation of cellular component organization negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of chromosome organization negative regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of defense response negative regulation of developmental process negative regulation of immune response negative regulation of immune system process negative regulation of innate immune response negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of nucleotide biosynthetic process negative regulation of nucleotide metabolic process negative regulation of organelle organization negative regulation of phosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of purine nucleotide biosynthetic process negative regulation of purine nucleotide metabolic process negative regulation of response to biotic stimulus negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of small molecule metabolic process negative regulation of telomere maintenance via telomere lengthening negative regulation of telomere maintenance negative regulation of transcription by RNA polymerase II negative regulation of transcription elongation by RNA polymerase II nitrogen compound metabolic process non-membrane-bounded organelle nuclear body nuclear envelope nuclear estrogen receptor binding nuclear receptor binding nuclear replication fork nucleic acid binding nucleic acid metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleolus nucleoplasm nucleoside phosphate binding nucleoside phosphate metabolic process nucleoside triphosphate metabolic process nucleosome binding nucleotide binding nucleotide metabolic process nucleotidyltransferase activity nucleus organelle envelope organelle organization organelle organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound metabolic process organophosphate metabolic process pentosyltransferase activity phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of DNA metabolic process positive regulation of DNA recombination positive regulation of DNA repair positive regulation of DNA-templated transcription, elongation positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of SMAD protein signal transduction positive regulation of biological process positive regulation of biosynthetic process positive regulation of canonical NF-kappaB signal transduction positive regulation of cardiac muscle hypertrophy positive regulation of cell communication positive regulation of cell differentiation positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of developmental process positive regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair positive regulation of intracellular estrogen receptor signaling pathway positive regulation of intracellular signal transduction positive regulation of intracellular steroid hormone receptor signaling pathway positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of membrane depolarization positive regulation of metabolic process positive regulation of mitochondrial depolarization positive regulation of multicellular organismal process positive regulation of muscle hypertrophy positive regulation of myofibroblast differentiation positive regulation of necroptotic process positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of programmed cell death positive regulation of programmed necrotic cell death positive regulation of protein localization to nucleus positive regulation of protein localization positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of single strand break repair positive regulation of transcription by RNA polymerase II positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway post-translational protein modification primary metabolic process programmed cell death protein auto-ADP-ribosylation protein autoprocessing protein binding protein dimerization activity protein homodimerization activity protein kinase binding protein localization to chromatin protein localization to chromosome protein localization to organelle protein localization protein maturation protein metabolic process protein modification process protein poly-ADP-ribosylation protein processing protein-DNA complex protein-containing complex binding protein-containing complex proteolysis purine nucleoside triphosphate metabolic process purine nucleotide binding purine nucleotide metabolic process purine ribonucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine-containing compound metabolic process regulation of ATP biosynthetic process regulation of ATP metabolic process regulation of DNA metabolic process regulation of DNA recombination regulation of DNA repair regulation of DNA-templated transcription elongation regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of SMAD protein signal transduction regulation of adipose tissue development regulation of apoptotic process regulation of apoptotic signaling pathway regulation of base-excision repair regulation of behavior regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of canonical NF-kappaB signal transduction regulation of cardiac muscle hypertrophy regulation of catalytic activity regulation of cell communication regulation of cell differentiation regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular localization regulation of cellular metabolic process regulation of cellular process regulation of cellular response to stress regulation of chromosome organization regulation of circadian rhythm regulation of circadian sleep/wake cycle, non-REM sleep regulation of circadian sleep/wake cycle, sleep regulation of circadian sleep/wake cycle regulation of cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of developmental process regulation of double-strand break repair via homologous recombination regulation of double-strand break repair regulation of gene expression regulation of immune response regulation of immune system process regulation of innate immune response regulation of intracellular estrogen receptor signaling pathway regulation of intracellular signal transduction regulation of intracellular steroid hormone receptor signaling pathway regulation of intrinsic apoptotic signaling pathway regulation of localization regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of membrane depolarization regulation of membrane potential regulation of metabolic process regulation of mitochondrial depolarization regulation of mitochondrial membrane potential regulation of molecular function regulation of multicellular organismal process regulation of muscle adaptation regulation of muscle hypertrophy regulation of muscle system process regulation of myofibroblast differentiation regulation of necroptotic process regulation of neuron apoptotic process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of nucleotide biosynthetic process regulation of nucleotide metabolic process regulation of organelle organization regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of pattern recognition receptor signaling pathway regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of primary metabolic process regulation of programmed cell death regulation of programmed necrotic cell death regulation of protein localization to nucleus regulation of protein localization regulation of purine nucleotide biosynthetic process regulation of purine nucleotide metabolic process regulation of response to biotic stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of signal transduction regulation of signaling regulation of single strand break repair regulation of small molecule metabolic process regulation of system process regulation of telomere maintenance via telomere lengthening regulation of telomere maintenance regulation of transcription by RNA polymerase II regulation of transcription elongation by RNA polymerase II regulation of transmembrane receptor protein serine/threonine kinase signaling pathway replication fork processing replication fork reversal replication fork reproductive process response to UV response to abiotic stimulus response to alcohol response to aldosterone response to amyloid-beta response to biotic stimulus response to chemical response to corticosteroid response to endogenous stimulus response to external biotic stimulus response to external stimulus response to gamma radiation response to growth factor response to hormone response to inorganic substance response to insulin response to ionizing radiation response to ketone response to light stimulus response to lipid response to metal ion response to mineralocorticoid response to nerve growth factor response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to other organism response to oxidative stress response to oxygen-containing compound response to peptide hormone response to peptide response to radiation response to steroid hormone response to stimulus response to stress response to zinc ion ribonucleoside triphosphate metabolic process ribonucleotide metabolic process ribose phosphate metabolic process signal transduction involved in regulation of gene expression signal transduction site of DNA damage site of double-strand break small molecule binding small molecule metabolic process telomere maintenance telomere organization tissue development transcription by RNA polymerase II transcription factor binding transcription regulator activator activity transcription regulator complex transferase activity, transferring phosphorus-containing groups transferase activity transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor superfamily signaling pathway transition metal ion binding transmembrane receptor protein serine/threonine kinase signaling pathway ubiquitin protein ligase binding ubiquitin-like protein ligase binding zinc ion binding	GO:0000018 GO:0000122 GO:0000166 GO:0000723 GO:0000781 GO:0000785 GO:0002376 GO:0002521 GO:0002573 GO:0002682 GO:0002683 GO:0002831 GO:0002832 GO:0003006 GO:0003254 GO:0003674 GO:0003676 GO:0003677 GO:0003682 GO:0003684 GO:0003723 GO:0003824 GO:0003950 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005635 GO:0005654 GO:0005657 GO:0005667 GO:0005730 GO:0005739 GO:0005829 GO:0005975 GO:0006139 GO:0006140 GO:0006163 GO:0006259 GO:0006281 GO:0006282 GO:0006302 GO:0006304 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0006508 GO:0006725 GO:0006753 GO:0006793 GO:0006796 GO:0006807 GO:0006915 GO:0006950 GO:0006952 GO:0006955 GO:0006974 GO:0006979 GO:0006996 GO:0007005 GO:0007165 GO:0007166 GO:0007167 GO:0007178 GO:0007179 GO:0008047 GO:0008104 GO:0008134 GO:0008150 GO:0008152 GO:0008219 GO:0008270 GO:0009058 GO:0009059 GO:0009117 GO:0009141 GO:0009144 GO:0009150 GO:0009199 GO:0009205 GO:0009259 GO:0009314 GO:0009411 GO:0009416 GO:0009605 GO:0009607 GO:0009628 GO:0009719 GO:0009725 GO:0009888 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010033 GO:0010035 GO:0010038 GO:0010043 GO:0010212 GO:0010243 GO:0010332 GO:0010468 GO:0010556 GO:0010557 GO:0010558 GO:0010563 GO:0010569 GO:0010604 GO:0010605 GO:0010611 GO:0010613 GO:0010639 GO:0010646 GO:0010647 GO:0010648 GO:0012501 GO:0014070 GO:0014742 GO:0014743 GO:0016020 GO:0016043 GO:0016051 GO:0016070 GO:0016485 GO:0016540 GO:0016604 GO:0016740 GO:0016757 GO:0016763 GO:0016772 GO:0016779 GO:0016922 GO:0017076 GO:0018130 GO:0019219 GO:0019220 GO:0019222 GO:0019438 GO:0019538 GO:0019637 GO:0019693 GO:0019899 GO:0019900 GO:0019901 GO:0022414 GO:0023019 GO:0023051 GO:0023056 GO:0023057 GO:0030099 GO:0030154 GO:0030225 GO:0030234 GO:0030331 GO:0030554 GO:0030592 GO:0030808 GO:0030809 GO:0031297 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031347 GO:0031348 GO:0031491 GO:0031625 GO:0031960 GO:0031967 GO:0031975 GO:0032042 GO:0032101 GO:0032102 GO:0032200 GO:0032204 GO:0032205 GO:0032502 GO:0032774 GO:0032784 GO:0032785 GO:0032786 GO:0032868 GO:0032869 GO:0032870 GO:0032879 GO:0032880 GO:0032991 GO:0032993 GO:0033036 GO:0033043 GO:0033044 GO:0033143 GO:0033145 GO:0033146 GO:0033148 GO:0033365 GO:0033554 GO:0033993 GO:0034243 GO:0034244 GO:0034502 GO:0034599 GO:0034641 GO:0034644 GO:0034654 GO:0035861 GO:0036094 GO:0036211 GO:0039531 GO:0039532 GO:0042221 GO:0042391 GO:0042749 GO:0042752 GO:0042802 GO:0042803 GO:0042826 GO:0042981 GO:0043067 GO:0043068 GO:0043122 GO:0043123 GO:0043167 GO:0043169 GO:0043170 GO:0043207 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043412 GO:0043434 GO:0043502 GO:0043504 GO:0043523 GO:0043596 GO:0043687 GO:0044057 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0044281 GO:0044389 GO:0044419 GO:0044877 GO:0045005 GO:0045087 GO:0045088 GO:0045187 GO:0045188 GO:0045595 GO:0045597 GO:0045739 GO:0045824 GO:0045892 GO:0045893 GO:0045911 GO:0045934 GO:0045935 GO:0045936 GO:0045944 GO:0045980 GO:0046034 GO:0046332 GO:0046483 GO:0046697 GO:0046872 GO:0046914 GO:0046983 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048545 GO:0048583 GO:0048584 GO:0048585 GO:0048856 GO:0048869 GO:0050776 GO:0050777 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050795 GO:0050896 GO:0051052 GO:0051053 GO:0051054 GO:0051093 GO:0051094 GO:0051128 GO:0051129 GO:0051171 GO:0051172 GO:0051173 GO:0051174 GO:0051179 GO:0051239 GO:0051240 GO:0051241 GO:0051252 GO:0051253 GO:0051254 GO:0051276 GO:0051287 GO:0051385 GO:0051604 GO:0051641 GO:0051707 GO:0051716 GO:0051881 GO:0051900 GO:0051901 GO:0055086 GO:0060255 GO:0060341 GO:0060390 GO:0060391 GO:0060544 GO:0060545 GO:0061629 GO:0062012 GO:0062014 GO:0062098 GO:0062100 GO:0062197 GO:0062207 GO:0065007 GO:0065008 GO:0065009 GO:0070212 GO:0070213 GO:0070412 GO:0070727 GO:0070848 GO:0070887 GO:0071168 GO:0071214 GO:0071241 GO:0071248 GO:0071294 GO:0071310 GO:0071363 GO:0071375 GO:0071417 GO:0071478 GO:0071482 GO:0071495 GO:0071704 GO:0071840 GO:0071932 GO:0072521 GO:0080090 GO:0080134 GO:0080135 GO:0090092 GO:0090100 GO:0090257 GO:0090304 GO:0090734 GO:0097159 GO:0097305 GO:0098542 GO:0098687 GO:0098772 GO:0104004 GO:0110165 GO:0140096 GO:0140294 GO:0140297 GO:0140537 GO:0140677 GO:0140805 GO:0140806 GO:0140807 GO:0140808 GO:0140815 GO:0140816 GO:0140817 GO:0140822 GO:0141091 GO:0160049 GO:1900180 GO:1900182 GO:1900371 GO:1900372 GO:1900542 GO:1900543 GO:1901135 GO:1901265 GO:1901360 GO:1901362 GO:1901363 GO:1901564 GO:1901576 GO:1901652 GO:1901653 GO:1901654 GO:1901698 GO:1901699 GO:1901700 GO:1901701 GO:1902175 GO:1902531 GO:1902533 GO:1902679 GO:1902680 GO:1903376 GO:1903516 GO:1903518 GO:1903578 GO:1903579 GO:1903829 GO:1904044 GO:1904177 GO:1904178 GO:1904181 GO:1904356 GO:1904357 GO:1904645 GO:1904646 GO:1904760 GO:1904762 GO:1905051 GO:1905168 GO:1990089 GO:1990090 GO:1990404 GO:1990966 GO:2000779 GO:2000781 GO:2001141 GO:2001169 GO:2001170 GO:2001233 GO:2001242 GO:2001251
143	poly(ADP-ribose) polymerase family member 4	PARP4 Aliases: ARTD4 VAULT3 VPARP VWA5C p193 vault poly(ADP-ribose) polymerase von Willebrand factor A domain containing 5C	Homo sapiens (human)	9606			DNA binding DNA damage response DNA metabolic process DNA repair NAD+ ADP-ribosyltransferase activity NAD+- protein-aspartate ADP-ribosyltransferase activity NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity NAD+-protein ADP-ribosyltransferase activity NAD+-protein-glutamate ADP-ribosyltransferase activity binding biological_process catalytic activity, acting on a protein catalytic activity cellular anatomical entity cellular aromatic compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular response to stimulus cellular response to stress cellular_component cytoplasm cytosol defense response enzyme binding extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle glycosyltransferase activity heterocycle metabolic process inflammatory response intracellular membrane-bounded organelle intracellular organelle macromolecule metabolic process macromolecule modification membrane-bounded organelle membrane metabolic process microtubule molecular_function nitrogen compound metabolic process nucleic acid binding nucleic acid metabolic process nucleobase-containing compound metabolic process nucleoplasm nucleotidyltransferase activity nucleus organelle organic cyclic compound binding organic cyclic compound metabolic process organic substance metabolic process organonitrogen compound metabolic process pentosyltransferase activity polymeric cytoskeletal fiber primary metabolic process protein binding protein metabolic process protein modification process protein-containing complex response to chemical response to stimulus response to stress response to xenobiotic stimulus ribonucleoprotein complex spindle microtubule supramolecular complex supramolecular fiber supramolecular polymer transferase activity, transferring phosphorus-containing groups transferase activity vesicle	GO:0003674 GO:0003676 GO:0003677 GO:0003824 GO:0003950 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005874 GO:0005876 GO:0006139 GO:0006259 GO:0006281 GO:0006725 GO:0006807 GO:0006950 GO:0006952 GO:0006954 GO:0006974 GO:0008150 GO:0008152 GO:0009410 GO:0009987 GO:0016020 GO:0016740 GO:0016757 GO:0016763 GO:0016772 GO:0016779 GO:0019538 GO:0019899 GO:0031982 GO:0032991 GO:0033554 GO:0034641 GO:0036211 GO:0042221 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043230 GO:0043231 GO:0043412 GO:0044237 GO:0044238 GO:0046483 GO:0050896 GO:0051716 GO:0065010 GO:0070062 GO:0071704 GO:0090304 GO:0097159 GO:0099080 GO:0099081 GO:0099512 GO:0099513 GO:0110165 GO:0140096 GO:0140806 GO:0140807 GO:0140822 GO:0140844 GO:0140867 GO:1901360 GO:1901564 GO:1903561 GO:1990404 GO:1990904
146	adrenoceptor alpha 1D	ADRA1D	Homo sapiens (human)	9606			G protein-coupled amine receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor signaling pathway alpha-adrenergic receptor activity alpha1-adrenergic receptor activity binding biological regulation biological_process blood vessel diameter maintenance cell communication cell-cell signaling cellular anatomical entity cellular process cellular_component circulatory system process identical protein binding membrane molecular transducer activity molecular_function multicellular organismal process neuron-glial cell signaling phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane positive regulation of MAPK cascade positive regulation of biological process positive regulation of cell communication positive regulation of cell population proliferation positive regulation of cellular process positive regulation of cytosolic calcium ion concentration positive regulation of intracellular signal transduction positive regulation of multicellular organismal process positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of vasoconstriction protein binding regulation of MAPK cascade regulation of anatomical structure size regulation of biological process regulation of biological quality regulation of blood circulation regulation of cell communication regulation of cell population proliferation regulation of cellular process regulation of intracellular signal transduction regulation of multicellular organismal process regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of system process regulation of tube diameter regulation of tube size regulation of vasoconstriction signal transduction signaling receptor activity signaling system process transmembrane signaling receptor activity vascular process in circulatory system	GO:0003008 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0004930 GO:0004935 GO:0004936 GO:0004937 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0007154 GO:0007165 GO:0007186 GO:0007188 GO:0007189 GO:0007200 GO:0007204 GO:0007267 GO:0008150 GO:0008227 GO:0008284 GO:0009966 GO:0009967 GO:0009987 GO:0010646 GO:0010647 GO:0016020 GO:0019229 GO:0023051 GO:0023052 GO:0023056 GO:0032501 GO:0035150 GO:0035296 GO:0038023 GO:0042127 GO:0042802 GO:0043408 GO:0043410 GO:0044057 GO:0045907 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0050789 GO:0050794 GO:0051239 GO:0051240 GO:0060089 GO:0065007 GO:0065008 GO:0071875 GO:0071880 GO:0090066 GO:0097746 GO:0110165 GO:0150099 GO:1902531 GO:1902533 GO:1903522
147	adrenoceptor alpha 1B	ADRA1B	Homo sapiens (human)	9606			G protein-coupled amine receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor signaling pathway alpha-adrenergic receptor activity alpha1-adrenergic receptor activity binding biological regulation biological_process blood vessel diameter maintenance caveola cell communication cell-cell signaling cellular anatomical entity cellular process cellular_component circulatory system process cytoplasm intracellular membrane-bounded organelle intracellular organelle intracellular signal transduction membrane microdomain membrane raft membrane-bounded organelle membrane molecular transducer activity molecular_function multicellular organismal process neuron-glial cell signaling nuclear membrane nucleus organelle membrane organelle phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane raft plasma membrane region plasma membrane positive regulation of MAPK cascade positive regulation of biological process positive regulation of cell communication positive regulation of cellular process positive regulation of cytosolic calcium ion concentration positive regulation of intracellular signal transduction positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling protein binding protein dimerization activity protein heterodimerization activity regulation of MAPK cascade regulation of anatomical structure size regulation of biological process regulation of biological quality regulation of blood circulation regulation of cardiac muscle contraction regulation of cell communication regulation of cellular process regulation of heart contraction regulation of intracellular signal transduction regulation of multicellular organismal process regulation of muscle contraction regulation of muscle system process regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of striated muscle contraction regulation of system process regulation of tube diameter regulation of tube size regulation of vasoconstriction signal transduction signaling receptor activity signaling system process transmembrane signaling receptor activity vascular process in circulatory system	GO:0003008 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0004930 GO:0004935 GO:0004936 GO:0004937 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005737 GO:0005886 GO:0005901 GO:0006937 GO:0006942 GO:0007154 GO:0007165 GO:0007186 GO:0007188 GO:0007189 GO:0007200 GO:0007204 GO:0007267 GO:0008016 GO:0008150 GO:0008227 GO:0009966 GO:0009967 GO:0009987 GO:0010646 GO:0010647 GO:0016020 GO:0019229 GO:0023051 GO:0023052 GO:0023056 GO:0031090 GO:0031965 GO:0032501 GO:0035150 GO:0035296 GO:0035556 GO:0038023 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043408 GO:0043410 GO:0044057 GO:0044853 GO:0045121 GO:0046982 GO:0046983 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0050789 GO:0050794 GO:0051239 GO:0055117 GO:0060089 GO:0065007 GO:0065008 GO:0071875 GO:0071880 GO:0090066 GO:0090257 GO:0097746 GO:0098590 GO:0098857 GO:0110165 GO:0150099 GO:1902531 GO:1902533 GO:1903522
148	adrenoceptor alpha 1A	ADRA1A	Homo sapiens (human)	9606	Alzheimer's disease heroin dependence hypertension	DOID:10652 DOID:10763 DOID:9976	G protein-coupled amine receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway MAPK cascade adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor signaling pathway adult heart development alpha-adrenergic receptor activity alpha1-adrenergic receptor activity anatomical structure development animal organ development apoptotic process binding biological regulation biological_process blood vessel diameter maintenance caveola cell communication cell death cell growth involved in cardiac muscle cell development cell growth cell-cell signaling cellular anatomical entity cellular process cellular_component circulatory system process cytoplasm cytosol developmental cell growth developmental growth developmental process growth heart development intracellular membrane-bounded organelle intracellular organelle intracellular signal transduction membrane microdomain membrane raft membrane-bounded organelle membrane modulation of chemical synaptic transmission molecular transducer activity molecular_function multicellular organismal process muscle contraction muscle system process negative regulation of autophagy negative regulation of biological process negative regulation of blood circulation negative regulation of catabolic process negative regulation of cell population proliferation negative regulation of cellular catabolic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of heart contraction negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure negative regulation of heart rate negative regulation of metabolic process negative regulation of multicellular organismal process neuron-glial cell signaling norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure nuclear membrane nucleoplasm nucleus organelle membrane organelle phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway pilomotor reflex plasma membrane raft plasma membrane region plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade positive regulation of action potential positive regulation of biological process positive regulation of blood circulation positive regulation of cardiac muscle contraction positive regulation of cardiac muscle hypertrophy positive regulation of cell communication positive regulation of cellular process positive regulation of cytosolic calcium ion concentration positive regulation of heart contraction positive regulation of heart rate by epinephrine-norepinephrine positive regulation of heart rate positive regulation of intracellular signal transduction positive regulation of multicellular organismal process positive regulation of muscle contraction positive regulation of muscle hypertrophy positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of smooth muscle contraction positive regulation of striated muscle contraction positive regulation of synaptic transmission, GABAergic positive regulation of synaptic transmission positive regulation of the force of heart contraction by chemical signal positive regulation of the force of heart contraction by epinephrine-norepinephrine positive regulation of vasoconstriction programmed cell death protein binding protein dimerization activity protein heterodimerization activity reflex regulation of ERK1 and ERK2 cascade regulation of MAPK cascade regulation of action potential regulation of anatomical structure size regulation of autophagy regulation of biological process regulation of biological quality regulation of blood circulation regulation of cardiac muscle contraction regulation of cardiac muscle hypertrophy regulation of catabolic process regulation of cell communication regulation of cell population proliferation regulation of cellular catabolic process regulation of cellular metabolic process regulation of cellular process regulation of heart contraction regulation of heart rate regulation of intracellular signal transduction regulation of membrane potential regulation of metabolic process regulation of multicellular organismal process regulation of muscle adaptation regulation of muscle contraction regulation of muscle hypertrophy regulation of muscle system process regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of smooth muscle contraction regulation of striated muscle contraction regulation of synaptic transmission, GABAergic regulation of system process regulation of the force of heart contraction by chemical signal regulation of the force of heart contraction regulation of trans-synaptic signaling regulation of tube diameter regulation of tube size regulation of vasoconstriction response to chemical response to endogenous stimulus response to external stimulus response to hormone response to organic substance response to stimulus response to xenobiotic stimulus signal transduction signaling receptor activity signaling smooth muscle contraction system process transmembrane signaling receptor activity vascular process in circulatory system vasoconstriction	GO:0000165 GO:0001985 GO:0001994 GO:0001996 GO:0001997 GO:0002026 GO:0002027 GO:0003008 GO:0003012 GO:0003013 GO:0003018 GO:0003057 GO:0003099 GO:0003674 GO:0004888 GO:0004930 GO:0004935 GO:0004936 GO:0004937 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0005901 GO:0006915 GO:0006936 GO:0006937 GO:0006939 GO:0006940 GO:0006942 GO:0007154 GO:0007165 GO:0007186 GO:0007188 GO:0007189 GO:0007200 GO:0007204 GO:0007267 GO:0007507 GO:0007512 GO:0008016 GO:0008150 GO:0008219 GO:0008227 GO:0008285 GO:0009410 GO:0009605 GO:0009719 GO:0009725 GO:0009892 GO:0009894 GO:0009895 GO:0009966 GO:0009967 GO:0009987 GO:0010033 GO:0010459 GO:0010460 GO:0010506 GO:0010507 GO:0010611 GO:0010613 GO:0010646 GO:0010647 GO:0012501 GO:0014742 GO:0014743 GO:0016020 GO:0016049 GO:0019222 GO:0019229 GO:0023051 GO:0023052 GO:0023056 GO:0031090 GO:0031323 GO:0031324 GO:0031329 GO:0031330 GO:0031965 GO:0032228 GO:0032230 GO:0032501 GO:0032502 GO:0035150 GO:0035296 GO:0035556 GO:0038023 GO:0040007 GO:0042127 GO:0042221 GO:0042310 GO:0042391 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043408 GO:0043410 GO:0043502 GO:0044057 GO:0044853 GO:0045121 GO:0045760 GO:0045822 GO:0045823 GO:0045907 GO:0045933 GO:0045987 GO:0045989 GO:0046982 GO:0046983 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048588 GO:0048589 GO:0048856 GO:0050789 GO:0050794 GO:0050804 GO:0050806 GO:0050896 GO:0051239 GO:0051240 GO:0051241 GO:0055117 GO:0060004 GO:0060089 GO:0060452 GO:0061049 GO:0065007 GO:0065008 GO:0070372 GO:0070374 GO:0071875 GO:0071880 GO:0071882 GO:0090066 GO:0090257 GO:0097195 GO:0097746 GO:0098590 GO:0098857 GO:0098900 GO:0099177 GO:0110165 GO:0150099 GO:1902531 GO:1902533 GO:1903522 GO:1903523 GO:1903524
150	adrenoceptor alpha 2A	ADRA2A	Homo sapiens (human)	9606	alcohol dependence attention deficit hyperactivity disorder familial partial lipodystrophy nicotine dependence substance abuse type 2 diabetes mellitus	DOID:0050440 DOID:0050741 DOID:0050742 DOID:1094 DOID:302 DOID:9352	DNA metabolic process DNA replication G protein-coupled amine receptor activity G protein-coupled receptor activity G protein-coupled receptor binding G protein-coupled receptor signaling pathway GABA-ergic synapse GTPase regulator activity Ras protein signal transduction Rho protein signal transduction actin cytoskeleton organization actin filament-based process activation of protein kinase B activity activation of protein kinase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor binding adrenergic receptor signaling pathway alpha-1B adrenergic receptor binding alpha-2C adrenergic receptor binding alpha-adrenergic receptor activity alpha2-adrenergic receptor activity axon terminus basolateral plasma membrane binding biological regulation biological_process blood vessel diameter maintenance carbohydrate homeostasis catecholamine binding cation binding cell activation cell body cell junction cellular anatomical entity cellular aromatic compound metabolic process cellular component organization or biogenesis cellular component organization cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular response to chemical stimulus cellular response to endogenous stimulus cellular response to hormone stimulus cellular response to organic substance cellular response to stimulus cellular_component chemical homeostasis circulatory system process cytoplasm cytoskeleton organization digestive system process dopaminergic synapse enzyme binding enzyme regulator activity epinephrine binding establishment of localization fear response female pregnancy glucose homeostasis glutamatergic synapse guanyl-nucleotide exchange factor activity heterocycle metabolic process heterotrimeric G-protein binding homeostatic process identical protein binding intestinal absorption intracellular signal transduction ion binding kinase binding localization macromolecule metabolic process membrane metabolic process modulation of chemical synaptic transmission molecular function regulator activity molecular transducer activity molecular_function multi-multicellular organism process multi-organism reproductive process multicellular organismal process multicellular organismal response to stress negative regulation of amine transport negative regulation of biological process negative regulation of calcium ion transmembrane transport negative regulation of calcium ion transmembrane transporter activity negative regulation of calcium ion transport negative regulation of calcium ion-dependent exocytosis negative regulation of catabolic process negative regulation of catecholamine secretion negative regulation of cation transmembrane transport negative regulation of cell communication negative regulation of cellular process negative regulation of epinephrine secretion negative regulation of establishment of protein localization negative regulation of exocytosis negative regulation of hormone secretion negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of insulin secretion negative regulation of ion transmembrane transporter activity negative regulation of lipid catabolic process negative regulation of lipid metabolic process negative regulation of metabolic process negative regulation of molecular function negative regulation of monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of multicellular organismal process negative regulation of muscle contraction negative regulation of norepinephrine secretion negative regulation of peptide hormone secretion negative regulation of peptide secretion negative regulation of protein localization negative regulation of protein secretion negative regulation of protein transport negative regulation of regulated secretory pathway negative regulation of response to stimulus negative regulation of secretion by cell negative regulation of secretion negative regulation of signaling negative regulation of smooth muscle contraction negative regulation of transmembrane transport negative regulation of transport negative regulation of transporter activity negative regulation of uterine smooth muscle contraction nervous system process neuron projection terminus neuronal cell body nitrogen compound metabolic process norepinephrine binding nucleic acid metabolic process nucleobase-containing compound metabolic process nucleoside-triphosphatase regulator activity organelle organization organic cyclic compound binding organic cyclic compound metabolic process organic substance metabolic process phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway plasma membrane region plasma membrane platelet activation positive regulation of ERBB signaling pathway positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of biological process positive regulation of biosynthetic process positive regulation of catabolic process positive regulation of catalytic activity positive regulation of cell communication positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cellular biosynthetic process positive regulation of cellular catabolic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of epidermal growth factor receptor signaling pathway positive regulation of gene expression positive regulation of intracellular signal transduction positive regulation of kinase activity positive regulation of locomotion positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of membrane protein ectodomain proteolysis positive regulation of metabolic process positive regulation of molecular function positive regulation of monoatomic ion transport positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of potassium ion transport positive regulation of protein catabolic process positive regulation of protein kinase activity positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of protein serine/threonine kinase activity positive regulation of proteolysis positive regulation of response to stimulus positive regulation of response to wounding positive regulation of signal transduction positive regulation of signaling receptor activity positive regulation of signaling positive regulation of transferase activity positive regulation of transport positive regulation of wound healing postsynaptic density membrane postsynaptic specialization membrane presynapse presynaptic active zone membrane presynaptic modulation of chemical synaptic transmission primary metabolic process protein binding protein dimerization activity protein heterodimerization activity protein homodimerization activity protein kinase binding protein-containing complex binding protein-containing complex receptor complex receptor transactivation regulation of ERBB signaling pathway regulation of MAP kinase activity regulation of MAPK cascade regulation of amine transport regulation of anatomical structure size regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of blood circulation regulation of calcium ion transmembrane transport regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of calcium ion-dependent exocytosis regulation of catabolic process regulation of catalytic activity regulation of catecholamine secretion regulation of cell communication regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular catabolic process regulation of cellular localization regulation of cellular metabolic process regulation of cellular process regulation of cytokine production regulation of epidermal growth factor receptor signaling pathway regulation of epinephrine secretion regulation of establishment of protein localization regulation of exocytosis regulation of gene expression regulation of hormone levels regulation of hormone secretion regulation of insulin secretion involved in cellular response to glucose stimulus regulation of insulin secretion regulation of intracellular signal transduction regulation of kinase activity regulation of lipid catabolic process regulation of lipid metabolic process regulation of localization regulation of locomotion regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of membrane protein ectodomain proteolysis regulation of metabolic process regulation of metal ion transport regulation of molecular function regulation of monoatomic cation transmembrane transport regulation of monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transporter activity regulation of monoatomic ion transport regulation of multicellular organismal process regulation of muscle contraction regulation of muscle system process regulation of nitrogen compound metabolic process regulation of norepinephrine secretion regulation of peptide hormone secretion regulation of peptide secretion regulation of peptide transport regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of potassium ion transport regulation of primary metabolic process regulation of protein catabolic process regulation of protein kinase activity regulation of protein localization regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of protein secretion regulation of protein serine/threonine kinase activity regulation of protein transport regulation of proteolysis regulation of regulated secretory pathway regulation of response to stimulus regulation of response to stress regulation of response to wounding regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling receptor activity regulation of signaling regulation of smooth muscle contraction regulation of system process regulation of trans-synaptic signaling regulation of transferase activity regulation of transmembrane transport regulation of transmembrane transporter activity regulation of transport regulation of transporter activity regulation of tube diameter regulation of tube size regulation of uterine smooth muscle contraction regulation of vasoconstriction regulation of vesicle-mediated transport regulation of wound healing reproductive process response to alcohol response to alkaloid response to chemical response to endogenous stimulus response to hormone response to isoquinoline alkaloid response to morphine response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to oxygen-containing compound response to salt response to stimulus response to stress sensory perception of temperature stimulus sensory perception signal transduction signaling receptor activity signaling receptor binding small GTPase mediated signal transduction synapse synaptic membrane system process thermoception thioesterase binding transmembrane signaling receptor activity transport vascular process in circulatory system vasodilation	GO:0001664 GO:0001775 GO:0001817 GO:0001819 GO:0001932 GO:0001934 GO:0002791 GO:0002792 GO:0003008 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0004930 GO:0004935 GO:0004936 GO:0004938 GO:0005085 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005737 GO:0005886 GO:0006139 GO:0006259 GO:0006260 GO:0006725 GO:0006807 GO:0006810 GO:0006937 GO:0006940 GO:0006950 GO:0006996 GO:0007010 GO:0007165 GO:0007186 GO:0007188 GO:0007189 GO:0007193 GO:0007200 GO:0007264 GO:0007265 GO:0007266 GO:0007565 GO:0007600 GO:0008150 GO:0008152 GO:0008227 GO:0008284 GO:0009719 GO:0009725 GO:0009889 GO:0009891 GO:0009892 GO:0009893 GO:0009894 GO:0009895 GO:0009896 GO:0009966 GO:0009967 GO:0009987 GO:0010033 GO:0010243 GO:0010468 GO:0010469 GO:0010556 GO:0010557 GO:0010562 GO:0010604 GO:0010628 GO:0010646 GO:0010647 GO:0010648 GO:0010700 GO:0010817 GO:0010959 GO:0014060 GO:0014061 GO:0014070 GO:0014072 GO:0016020 GO:0016043 GO:0016323 GO:0017157 GO:0017158 GO:0019216 GO:0019220 GO:0019222 GO:0019229 GO:0019899 GO:0019900 GO:0019901 GO:0022414 GO:0022600 GO:0022898 GO:0023051 GO:0023056 GO:0023057 GO:0030029 GO:0030036 GO:0030054 GO:0030162 GO:0030168 GO:0030234 GO:0030334 GO:0030335 GO:0030695 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031329 GO:0031331 GO:0031399 GO:0031401 GO:0031690 GO:0031692 GO:0031696 GO:0031996 GO:0032147 GO:0032148 GO:0032409 GO:0032410 GO:0032412 GO:0032413 GO:0032501 GO:0032795 GO:0032811 GO:0032870 GO:0032879 GO:0032880 GO:0032991 GO:0033500 GO:0033555 GO:0033604 GO:0033674 GO:0034641 GO:0034762 GO:0034763 GO:0034765 GO:0034766 GO:0035150 GO:0035296 GO:0035556 GO:0035624 GO:0038023 GO:0040012 GO:0040017 GO:0042058 GO:0042127 GO:0042176 GO:0042221 GO:0042311 GO:0042325 GO:0042327 GO:0042592 GO:0042593 GO:0042596 GO:0042802 GO:0042803 GO:0043025 GO:0043085 GO:0043167 GO:0043169 GO:0043170 GO:0043235 GO:0043266 GO:0043268 GO:0043269 GO:0043270 GO:0043271 GO:0043278 GO:0043279 GO:0043405 GO:0043406 GO:0043408 GO:0043410 GO:0043549 GO:0043679 GO:0044057 GO:0044092 GO:0044093 GO:0044237 GO:0044238 GO:0044297 GO:0044306 GO:0044703 GO:0044706 GO:0044877 GO:0045202 GO:0045732 GO:0045742 GO:0045833 GO:0045859 GO:0045860 GO:0045862 GO:0045920 GO:0045932 GO:0045937 GO:0045955 GO:0045986 GO:0046483 GO:0046676 GO:0046883 GO:0046888 GO:0046982 GO:0046983 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048787 GO:0048878 GO:0050433 GO:0050708 GO:0050709 GO:0050789 GO:0050790 GO:0050794 GO:0050796 GO:0050804 GO:0050877 GO:0050892 GO:0050896 GO:0050951 GO:0050955 GO:0050994 GO:0050995 GO:0051043 GO:0051044 GO:0051046 GO:0051048 GO:0051049 GO:0051050 GO:0051051 GO:0051171 GO:0051173 GO:0051174 GO:0051179 GO:0051223 GO:0051224 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051246 GO:0051247 GO:0051338 GO:0051347 GO:0051379 GO:0051380 GO:0051716 GO:0051924 GO:0051926 GO:0051952 GO:0051953 GO:0060089 GO:0060255 GO:0060341 GO:0060589 GO:0060627 GO:0061041 GO:0061178 GO:0061179 GO:0065007 GO:0065008 GO:0065009 GO:0070201 GO:0070472 GO:0070473 GO:0070887 GO:0071310 GO:0071495 GO:0071704 GO:0071840 GO:0071875 GO:0071880 GO:0071881 GO:0071882 GO:0071900 GO:0071902 GO:0080090 GO:0080134 GO:0090066 GO:0090087 GO:0090257 GO:0090276 GO:0090278 GO:0090303 GO:0090304 GO:0097060 GO:0097159 GO:0097305 GO:0097746 GO:0098590 GO:0098691 GO:0098772 GO:0098793 GO:0098839 GO:0098978 GO:0098982 GO:0099171 GO:0099177 GO:0099634 GO:0110165 GO:1901019 GO:1901020 GO:1901184 GO:1901186 GO:1901338 GO:1901360 GO:1901698 GO:1901700 GO:1902074 GO:1902531 GO:1902533 GO:1903034 GO:1903036 GO:1903169 GO:1903170 GO:1903305 GO:1903306 GO:1903522 GO:1903530 GO:1903531 GO:1903828 GO:1904062 GO:1904063 GO:1904950 GO:2000145 GO:2000147 GO:2000273
152	adrenoceptor alpha 2C	ADRA2C	Homo sapiens (human)	9606	congestive heart failure	DOID:6000	G protein-coupled amine receptor activity G protein-coupled receptor activity G protein-coupled receptor binding G protein-coupled receptor signaling pathway GTPase regulator activity activation of protein kinase B activity activation of protein kinase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor binding adrenergic receptor signaling pathway alpha-2A adrenergic receptor binding alpha-adrenergic receptor activity alpha2-adrenergic receptor activity binding biological regulation biological_process blood vessel diameter maintenance catecholamine binding cell activation cell communication cell-cell signaling cellular anatomical entity cellular process cellular_component circulatory system process cytoplasm cytoplasmic vesicle endosome enzyme regulator activity epinephrine binding guanyl-nucleotide exchange factor activity identical protein binding intracellular membrane-bounded organelle intracellular organelle intracellular vesicle membrane-bounded organelle membrane molecular function regulator activity molecular transducer activity molecular_function multicellular organismal process negative regulation of amine transport negative regulation of biological process negative regulation of catecholamine secretion negative regulation of cell communication negative regulation of cellular process negative regulation of epinephrine secretion negative regulation of establishment of protein localization negative regulation of hormone secretion negative regulation of insulin secretion negative regulation of norepinephrine secretion negative regulation of peptide hormone secretion negative regulation of peptide secretion negative regulation of protein localization negative regulation of protein secretion negative regulation of protein transport negative regulation of secretion by cell negative regulation of secretion negative regulation of signaling negative regulation of transport nucleoside-triphosphatase regulator activity organelle organic cyclic compound binding plasma membrane platelet activation positive regulation of MAPK cascade positive regulation of biological process positive regulation of catalytic activity positive regulation of cell communication positive regulation of cell differentiation positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of developmental process positive regulation of intracellular signal transduction positive regulation of kinase activity positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of neuron differentiation positive regulation of nitrogen compound metabolic process positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of protein kinase activity positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling receptor activity positive regulation of signaling positive regulation of transferase activity protein binding protein dimerization activity protein heterodimerization activity protein homodimerization activity receptor transactivation regulation of MAPK cascade regulation of amine transport regulation of anatomical structure size regulation of biological process regulation of biological quality regulation of blood circulation regulation of catalytic activity regulation of catecholamine secretion regulation of cell communication regulation of cell differentiation regulation of cellular localization regulation of cellular metabolic process regulation of cellular process regulation of developmental process regulation of epinephrine secretion regulation of establishment of protein localization regulation of hormone levels regulation of hormone secretion regulation of insulin secretion regulation of intracellular signal transduction regulation of kinase activity regulation of localization regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of multicellular organismal process regulation of muscle contraction regulation of muscle system process regulation of neuron differentiation regulation of nitrogen compound metabolic process regulation of norepinephrine secretion regulation of peptide hormone secretion regulation of peptide secretion regulation of peptide transport regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of primary metabolic process regulation of protein kinase activity regulation of protein localization regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of protein secretion regulation of protein transport regulation of response to stimulus regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling receptor activity regulation of signaling regulation of smooth muscle contraction regulation of system process regulation of transferase activity regulation of transport regulation of tube diameter regulation of tube size regulation of vasoconstriction signal transduction signaling receptor activity signaling receptor binding signaling system process transmembrane signaling receptor activity vascular process in circulatory system vesicle	GO:0001664 GO:0001775 GO:0001932 GO:0001934 GO:0002791 GO:0002792 GO:0003008 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0004930 GO:0004935 GO:0004936 GO:0004938 GO:0005085 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005737 GO:0005768 GO:0005886 GO:0006937 GO:0006940 GO:0007154 GO:0007165 GO:0007186 GO:0007188 GO:0007189 GO:0007267 GO:0008150 GO:0008227 GO:0009893 GO:0009966 GO:0009967 GO:0009987 GO:0010469 GO:0010562 GO:0010604 GO:0010646 GO:0010647 GO:0010648 GO:0010700 GO:0010817 GO:0014060 GO:0014061 GO:0016020 GO:0019220 GO:0019222 GO:0019229 GO:0023051 GO:0023052 GO:0023056 GO:0023057 GO:0030168 GO:0030234 GO:0030695 GO:0031323 GO:0031325 GO:0031399 GO:0031401 GO:0031410 GO:0031690 GO:0031694 GO:0031982 GO:0032147 GO:0032148 GO:0032501 GO:0032811 GO:0032879 GO:0032880 GO:0033604 GO:0033674 GO:0035150 GO:0035296 GO:0035624 GO:0038023 GO:0042325 GO:0042327 GO:0042802 GO:0042803 GO:0043085 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043408 GO:0043410 GO:0043549 GO:0044057 GO:0044093 GO:0045595 GO:0045597 GO:0045664 GO:0045666 GO:0045859 GO:0045860 GO:0045937 GO:0046676 GO:0046883 GO:0046888 GO:0046982 GO:0046983 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0050433 GO:0050708 GO:0050709 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050796 GO:0051046 GO:0051048 GO:0051049 GO:0051051 GO:0051094 GO:0051171 GO:0051173 GO:0051174 GO:0051223 GO:0051224 GO:0051239 GO:0051246 GO:0051247 GO:0051338 GO:0051347 GO:0051379 GO:0051952 GO:0051953 GO:0060089 GO:0060255 GO:0060341 GO:0060589 GO:0065007 GO:0065008 GO:0065009 GO:0070201 GO:0071875 GO:0071880 GO:0080090 GO:0090066 GO:0090087 GO:0090257 GO:0090276 GO:0090278 GO:0097159 GO:0097708 GO:0097746 GO:0098772 GO:0110165 GO:1901338 GO:1902531 GO:1902533 GO:1903522 GO:1903530 GO:1903531 GO:1903828 GO:1904950 GO:2000273
153	adrenoceptor beta 1	ADRB1	Homo sapiens (human)	9606	chronic obstructive pulmonary disease congestive heart failure hypertension low tension glaucoma nephrosclerosis obstructive sleep apnea periodontitis	DOID:0050848 DOID:10763 DOID:11664 DOID:13544 DOID:3083 DOID:6000 DOID:824	G protein-coupled amine receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential G protein-coupled neurotransmitter receptor activity G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential G protein-coupled receptor activity G protein-coupled receptor binding G protein-coupled receptor signaling pathway PDZ domain binding Schaffer collateral - CA1 synapse adaptive thermogenesis adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor binding adrenergic receptor signaling pathway alpha-2A adrenergic receptor binding beta-adrenergic receptor activity beta1-adrenergic receptor activity binding biological regulation biological_process blood vessel diameter maintenance brown fat cell differentiation cell differentiation cell junction cellular anatomical entity cellular developmental process cellular process cellular_component circulatory system process cytoplasmic vesicle dense core granule developmental process diet induced thermogenesis early endosome endosome fat cell differentiation fear response heat generation homeostatic process intracellular membrane-bounded organelle intracellular organelle intracellular vesicle membrane-bounded organelle membrane metabolic process molecular transducer activity molecular_function multicellular organismal process multicellular organismal response to stress multicellular organismal-level homeostasis negative regulation of biological process negative regulation of blood pressure negative regulation of developmental growth negative regulation of developmental process negative regulation of growth negative regulation of multicellular organism growth negative regulation of multicellular organismal process negative regulation of systemic arterial blood pressure neuronal dense core vesicle neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure organelle plasma membrane positive regulation of MAPK cascade positive regulation of biological process positive regulation of blood circulation positive regulation of cell communication positive regulation of cellular process positive regulation of cold-induced thermogenesis positive regulation of heart contraction positive regulation of heart rate by epinephrine-norepinephrine positive regulation of heart rate positive regulation of intracellular signal transduction positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of the force of heart contraction by chemical signal positive regulation of the force of heart contraction by epinephrine-norepinephrine postsynaptic neurotransmitter receptor activity protein binding protein dimerization activity protein domain specific binding protein heterodimerization activity regulation of MAPK cascade regulation of anatomical structure size regulation of behavior regulation of biological process regulation of biological quality regulation of blood circulation regulation of blood pressure regulation of cell communication regulation of cellular process regulation of circadian rhythm regulation of circadian sleep/wake cycle, sleep regulation of circadian sleep/wake cycle regulation of cold-induced thermogenesis regulation of developmental growth regulation of developmental process regulation of growth regulation of heart contraction regulation of heart rate regulation of intracellular signal transduction regulation of membrane potential regulation of metabolic process regulation of multicellular organism growth regulation of multicellular organismal process regulation of postsynaptic membrane potential regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of system process regulation of the force of heart contraction by chemical signal regulation of the force of heart contraction regulation of tube diameter regulation of tube size response to abiotic stimulus response to cold response to stimulus response to stress response to temperature stimulus secretory granule secretory vesicle signal transduction signaling receptor activity signaling receptor binding synapse system process temperature homeostasis transmembrane signaling receptor activity vascular process in circulatory system vasodilation vesicle	GO:0001659 GO:0001664 GO:0001996 GO:0001997 GO:0002024 GO:0002025 GO:0002026 GO:0002027 GO:0003008 GO:0003013 GO:0003018 GO:0003057 GO:0003085 GO:0003099 GO:0003674 GO:0004888 GO:0004930 GO:0004935 GO:0004939 GO:0004940 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005768 GO:0005769 GO:0005886 GO:0006950 GO:0007165 GO:0007186 GO:0007188 GO:0007189 GO:0008016 GO:0008150 GO:0008152 GO:0008217 GO:0008227 GO:0009266 GO:0009409 GO:0009628 GO:0009893 GO:0009966 GO:0009967 GO:0009987 GO:0010460 GO:0010646 GO:0010647 GO:0016020 GO:0019222 GO:0019904 GO:0023051 GO:0023056 GO:0030054 GO:0030141 GO:0030154 GO:0030165 GO:0030594 GO:0031045 GO:0031410 GO:0031649 GO:0031690 GO:0031694 GO:0031982 GO:0032501 GO:0032502 GO:0033555 GO:0035150 GO:0035296 GO:0038023 GO:0040008 GO:0040014 GO:0040015 GO:0042311 GO:0042391 GO:0042592 GO:0042596 GO:0042749 GO:0042752 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043408 GO:0043410 GO:0044057 GO:0045187 GO:0045202 GO:0045444 GO:0045776 GO:0045823 GO:0045926 GO:0046982 GO:0046983 GO:0048518 GO:0048519 GO:0048522 GO:0048583 GO:0048584 GO:0048638 GO:0048640 GO:0048869 GO:0048871 GO:0050789 GO:0050793 GO:0050794 GO:0050795 GO:0050873 GO:0050896 GO:0051093 GO:0051239 GO:0051240 GO:0051241 GO:0060078 GO:0060089 GO:0065007 GO:0065008 GO:0071875 GO:0071880 GO:0090066 GO:0097708 GO:0097746 GO:0098685 GO:0098960 GO:0098992 GO:0099503 GO:0099528 GO:0099529 GO:0099530 GO:0099579 GO:0110165 GO:0120161 GO:0120162 GO:1902531 GO:1902533 GO:1903522 GO:1903524 GO:1990845
154	adrenoceptor beta 2	ADRB2	Homo sapiens (human)	9606	Graves' disease acute kidney failure asthma bronchiolitis chronic obstructive pulmonary disease cystic fibrosis dermatitis disease of metabolism end stage renal disease familial hypercholesterolemia hypertension interstitial cystitis myasthenia gravis myocardial infarction obesity open-angle glaucoma primary open angle glaucoma psoriasis pulmonary edema steatotic liver disease toxic shock syndrome urticaria	DOID:0014667 DOID:1067 DOID:1070 DOID:10763 DOID:11396 DOID:12361 DOID:13810 DOID:13949 DOID:14115 DOID:1485 DOID:1555 DOID:2723 DOID:2841 DOID:2942 DOID:3021 DOID:3083 DOID:437 DOID:5844 DOID:783 DOID:8893 DOID:9452 DOID:9970	AMPA selective glutamate receptor signaling pathway DNA-templated transcription G protein-coupled amine receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway Golgi apparatus RNA biosynthetic process RNA metabolic process activation of protein kinase activity activation of transmembrane receptor protein tyrosine kinase activity adaptive thermogenesis adenylate cyclase binding adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor signaling pathway amide binding amyloid-beta binding anatomical structure homeostasis apical plasma membrane aromatic compound biosynthetic process beta-adrenergic receptor activity beta2-adrenergic receptor activity binding biological regulation biological_process biosynthetic process blood vessel diameter maintenance bone resorption bounding membrane of organelle brown fat cell differentiation catecholamine binding cation binding cell differentiation cell projection cell surface receptor signaling pathway cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular component assembly cellular component organization or biogenesis cellular component organization cellular developmental process cellular localization cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular response to amyloid-beta cellular response to chemical stimulus cellular response to endogenous stimulus cellular response to nitrogen compound cellular response to organic substance cellular response to organonitrogen compound cellular response to oxygen-containing compound cellular response to peptide cellular response to stimulus cellular_component channel regulator activity ciliary basal body cilium circulatory system process clathrin-coated endocytic vesicle membrane clathrin-coated vesicle membrane coated vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle cytoskeleton dense core granule developmental process diet induced thermogenesis early endosome endocytic vesicle membrane endocytosis endosome membrane endosome to lysosome transport endosome enzyme binding establishment of localization in cell establishment of localization fat cell differentiation glutamate receptor signaling pathway heat generation heterocycle biosynthetic process heterocycle metabolic process homeostatic process identical protein binding import into cell intercellular bridge intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle intracellular transport intracellular vesicle ion binding ion channel regulator activity ionotropic glutamate receptor signaling pathway ligand-gated ion channel signaling pathway localization lysosomal transport lysosome lytic vacuole macromolecule biosynthetic process macromolecule metabolic process membrane-bounded organelle membrane metabolic process microtubule cytoskeleton microtubule organizing center mitotic spindle modulation of chemical synaptic transmission modulation of excitatory postsynaptic potential molecular function regulator activity molecular transducer activity molecular_function multicellular organismal process multicellular organismal-level homeostasis muscle contraction muscle system process negative regulation of G protein-coupled receptor signaling pathway negative regulation of biological process negative regulation of blood pressure negative regulation of cell communication negative regulation of cellular process negative regulation of developmental growth negative regulation of developmental process negative regulation of growth negative regulation of multicellular organism growth negative regulation of multicellular organismal process negative regulation of muscle contraction negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of smooth muscle contraction negative regulation of systemic arterial blood pressure neuronal dense core vesicle nitrogen compound metabolic process non-membrane-bounded organelle norepinephrine binding norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure nucleic acid metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleus organelle membrane organelle organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process peptide binding plasma membrane bounded cell projection plasma membrane region plasma membrane positive regulation of DNA-templated transcription positive regulation of MAPK cascade positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of autophagosome maturation positive regulation of autophagy positive regulation of biological process positive regulation of biomineral tissue development positive regulation of biosynthetic process positive regulation of bone mineralization positive regulation of catabolic process positive regulation of catalytic activity positive regulation of cell communication positive regulation of cellular biosynthetic process positive regulation of cellular catabolic process positive regulation of cellular component organization positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cold-induced thermogenesis positive regulation of developmental process positive regulation of excitatory postsynaptic potential positive regulation of intracellular signal transduction positive regulation of kinase activity positive regulation of lipophagy positive regulation of macroautophagy positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of mini excitatory postsynaptic potential positive regulation of molecular function positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of organelle organization positive regulation of ossification positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of protein kinase activity positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of protein-containing complex disassembly positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of transcription by RNA polymerase II positive regulation of transferase activity potassium channel regulator activity primary metabolic process protein binding protein dimerization activity protein homodimerization activity protein-containing complex assembly protein-containing complex binding protein-containing complex organization protein-containing complex receptor complex receptor-mediated endocytosis regulation of DNA-templated transcription regulation of G protein-coupled receptor signaling pathway regulation of MAPK cascade regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of anatomical structure size regulation of autophagosome maturation regulation of autophagy regulation of biological process regulation of biological quality regulation of biomineral tissue development regulation of biosynthetic process regulation of blood pressure regulation of bone mineralization regulation of catabolic process regulation of catalytic activity regulation of cell communication regulation of cellular biosynthetic process regulation of cellular catabolic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cold-induced thermogenesis regulation of developmental growth regulation of developmental process regulation of gene expression regulation of growth regulation of intracellular signal transduction regulation of kinase activity regulation of lipophagy regulation of localization regulation of macroautophagy regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of membrane potential regulation of metabolic process regulation of metal ion transport regulation of mini excitatory postsynaptic potential regulation of molecular function regulation of monoatomic ion transport regulation of multicellular organism growth regulation of multicellular organismal development regulation of multicellular organismal process regulation of muscle contraction regulation of muscle system process regulation of nervous system process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of organelle organization regulation of ossification regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of primary metabolic process regulation of protein kinase activity regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of protein-containing complex disassembly regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of smooth muscle contraction regulation of sodium ion transport regulation of system process regulation of trans-synaptic signaling regulation of transcription by RNA polymerase II regulation of transferase activity regulation of transport regulation of tube diameter regulation of tube size response to abiotic stimulus response to amyloid-beta response to chemical response to cold response to endogenous stimulus response to nitrogen compound response to organic substance response to organonitrogen compound response to oxygen-containing compound response to peptide response to psychosocial stress response to stimulus response to stress response to temperature stimulus secretory granule secretory vesicle signal transduction signaling receptor activity smooth muscle contraction spindle system process temperature homeostasis tissue homeostasis transcription by RNA polymerase II transmembrane signaling receptor activity transport transporter regulator activity vacuolar transport vacuole vascular process in circulatory system vasodilation vesicle membrane vesicle-mediated transport vesicle	GO:0000323 GO:0001540 GO:0001659 GO:0001894 GO:0001932 GO:0001934 GO:0002024 GO:0002025 GO:0002028 GO:0003008 GO:0003012 GO:0003013 GO:0003018 GO:0003085 GO:0003674 GO:0004888 GO:0004930 GO:0004935 GO:0004939 GO:0004941 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005764 GO:0005768 GO:0005769 GO:0005773 GO:0005794 GO:0005815 GO:0005819 GO:0005856 GO:0005886 GO:0005929 GO:0006139 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0006725 GO:0006807 GO:0006810 GO:0006897 GO:0006898 GO:0006936 GO:0006937 GO:0006939 GO:0006940 GO:0006950 GO:0007034 GO:0007041 GO:0007165 GO:0007166 GO:0007171 GO:0007186 GO:0007188 GO:0007189 GO:0007215 GO:0008150 GO:0008152 GO:0008179 GO:0008217 GO:0008227 GO:0008277 GO:0008333 GO:0009058 GO:0009059 GO:0009266 GO:0009409 GO:0009628 GO:0009719 GO:0009889 GO:0009891 GO:0009893 GO:0009894 GO:0009896 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010008 GO:0010033 GO:0010243 GO:0010468 GO:0010506 GO:0010508 GO:0010556 GO:0010557 GO:0010562 GO:0010604 GO:0010638 GO:0010646 GO:0010647 GO:0010648 GO:0010959 GO:0012506 GO:0015459 GO:0015630 GO:0016020 GO:0016043 GO:0016070 GO:0016192 GO:0016239 GO:0016241 GO:0016247 GO:0016324 GO:0018130 GO:0019219 GO:0019220 GO:0019222 GO:0019438 GO:0019899 GO:0022607 GO:0023051 GO:0023056 GO:0023057 GO:0030141 GO:0030154 GO:0030278 GO:0030500 GO:0030501 GO:0030659 GO:0030662 GO:0030665 GO:0030666 GO:0030669 GO:0031045 GO:0031090 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031329 GO:0031331 GO:0031399 GO:0031401 GO:0031410 GO:0031644 GO:0031649 GO:0031982 GO:0032147 GO:0032501 GO:0032502 GO:0032774 GO:0032879 GO:0032991 GO:0033043 GO:0033218 GO:0033674 GO:0034641 GO:0034654 GO:0035150 GO:0035235 GO:0035296 GO:0036064 GO:0038023 GO:0040008 GO:0040014 GO:0040015 GO:0042221 GO:0042277 GO:0042311 GO:0042325 GO:0042327 GO:0042391 GO:0042592 GO:0042802 GO:0042803 GO:0042995 GO:0043085 GO:0043167 GO:0043169 GO:0043170 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043235 GO:0043243 GO:0043244 GO:0043269 GO:0043408 GO:0043410 GO:0043549 GO:0043933 GO:0044057 GO:0044093 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0044877 GO:0045171 GO:0045444 GO:0045453 GO:0045744 GO:0045776 GO:0045778 GO:0045859 GO:0045860 GO:0045893 GO:0045926 GO:0045932 GO:0045935 GO:0045937 GO:0045944 GO:0045986 GO:0046483 GO:0046907 GO:0046983 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048638 GO:0048640 GO:0048869 GO:0048871 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050804 GO:0050873 GO:0050896 GO:0051049 GO:0051093 GO:0051094 GO:0051128 GO:0051130 GO:0051171 GO:0051173 GO:0051174 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051246 GO:0051247 GO:0051252 GO:0051254 GO:0051338 GO:0051347 GO:0051380 GO:0051641 GO:0051649 GO:0051716 GO:0060089 GO:0060249 GO:0060255 GO:0061884 GO:0061885 GO:0065003 GO:0065007 GO:0065008 GO:0065009 GO:0070167 GO:0070169 GO:0070887 GO:0071310 GO:0071417 GO:0071495 GO:0071704 GO:0071840 GO:0071875 GO:0071880 GO:0072686 GO:0080090 GO:0090066 GO:0090257 GO:0090304 GO:0097159 GO:0097708 GO:0097746 GO:0098588 GO:0098590 GO:0098657 GO:0098772 GO:0098815 GO:0098990 GO:0098992 GO:0099106 GO:0099177 GO:0099503 GO:0110165 GO:0120025 GO:0120161 GO:0120162 GO:0141108 GO:1901096 GO:1901098 GO:1901338 GO:1901360 GO:1901362 GO:1901576 GO:1901652 GO:1901653 GO:1901698 GO:1901699 GO:1901700 GO:1901701 GO:1902531 GO:1902533 GO:1902680 GO:1904502 GO:1904504 GO:1904645 GO:1904646 GO:1990806 GO:1990845 GO:1990911 GO:2000026 GO:2000463 GO:2001141
155	adrenoceptor beta 3	ADRB3	Homo sapiens (human)	9606	Alzheimer's disease coronary artery disease diabetic retinopathy dilated cardiomyopathy 1H endometrial cancer gout hypertension metabolic dysfunction-associated steatotic liver disease obesity rheumatoid arthritis type 2 diabetes mellitus	DOID:0080208 DOID:0110429 DOID:10652 DOID:10763 DOID:13189 DOID:1380 DOID:3393 DOID:7148 DOID:8947 DOID:9352 DOID:9970	G protein-coupled amine receptor activity G protein-coupled receptor activity G protein-coupled receptor binding G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein-coupled receptor signaling pathway adaptive thermogenesis adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor binding adrenergic receptor signaling pathway behavior beta-3 adrenergic receptor binding beta-adrenergic receptor activity beta3-adrenergic receptor activity binding biological regulation biological_process blood vessel diameter maintenance brown fat cell differentiation carbohydrate metabolic process catecholamine binding cation binding cell differentiation cellular anatomical entity cellular developmental process cellular metabolic process cellular process cellular_component circulatory system process developmental process diet induced thermogenesis eating behavior endocytosis energy derivation by oxidation of organic compounds energy reserve metabolic process epinephrine binding establishment of localization fat cell differentiation feeding behavior generation of precursor metabolites and energy heat generation homeostatic process identical protein binding import into cell ion binding localization membrane metabolic process molecular transducer activity molecular_function multicellular organismal process multicellular organismal-level homeostasis negative regulation of G protein-coupled receptor signaling pathway negative regulation of biological process negative regulation of blood pressure negative regulation of cell communication negative regulation of cellular process negative regulation of developmental growth negative regulation of developmental process negative regulation of growth negative regulation of multicellular organism growth negative regulation of multicellular organismal process negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of systemic arterial blood pressure norepinephrine binding norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure organic cyclic compound binding organic substance metabolic process plasma membrane positive regulation of MAPK cascade positive regulation of biological process positive regulation of cell communication positive regulation of cellular process positive regulation of cold-induced thermogenesis positive regulation of intracellular signal transduction positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling primary metabolic process protein binding protein dimerization activity protein homodimerization activity protein-containing complex receptor complex receptor-mediated endocytosis regulation of G protein-coupled receptor signaling pathway regulation of MAPK cascade regulation of anatomical structure size regulation of biological process regulation of biological quality regulation of blood pressure regulation of cell communication regulation of cellular process regulation of cold-induced thermogenesis regulation of developmental growth regulation of developmental process regulation of growth regulation of intracellular signal transduction regulation of metabolic process regulation of multicellular organism growth regulation of multicellular organismal process regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of tube diameter regulation of tube size response to abiotic stimulus response to cold response to stimulus response to stress response to temperature stimulus signal transduction signaling receptor activity signaling receptor binding system process temperature homeostasis transmembrane signaling receptor activity transport vascular process in circulatory system vasodilation vesicle-mediated transport	GO:0001659 GO:0001664 GO:0002024 GO:0002025 GO:0003008 GO:0003013 GO:0003018 GO:0003085 GO:0003674 GO:0004888 GO:0004930 GO:0004935 GO:0004939 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0005975 GO:0006091 GO:0006112 GO:0006810 GO:0006897 GO:0006898 GO:0006950 GO:0007165 GO:0007186 GO:0007187 GO:0007188 GO:0007189 GO:0007610 GO:0007631 GO:0008150 GO:0008152 GO:0008217 GO:0008227 GO:0008277 GO:0009266 GO:0009409 GO:0009628 GO:0009893 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010646 GO:0010647 GO:0010648 GO:0015052 GO:0015980 GO:0016020 GO:0016192 GO:0019222 GO:0023051 GO:0023056 GO:0023057 GO:0030154 GO:0031649 GO:0031690 GO:0031699 GO:0032501 GO:0032502 GO:0032991 GO:0035150 GO:0035296 GO:0038023 GO:0040008 GO:0040014 GO:0040015 GO:0042311 GO:0042592 GO:0042755 GO:0042802 GO:0042803 GO:0043167 GO:0043169 GO:0043235 GO:0043408 GO:0043410 GO:0044237 GO:0044238 GO:0045444 GO:0045744 GO:0045776 GO:0045926 GO:0046983 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048638 GO:0048640 GO:0048869 GO:0048871 GO:0050789 GO:0050793 GO:0050794 GO:0050873 GO:0050896 GO:0051093 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051379 GO:0051380 GO:0060089 GO:0065007 GO:0065008 GO:0071704 GO:0071875 GO:0071880 GO:0090066 GO:0097159 GO:0097746 GO:0098657 GO:0110165 GO:0120161 GO:0120162 GO:1901338 GO:1902531 GO:1902533 GO:1990845
157	G protein-coupled receptor kinase 3	GRK3	Homo sapiens (human)	9606			ATP binding G protein-coupled receptor binding G protein-coupled receptor kinase activity G protein-coupled receptor signaling pathway adaptation of signaling pathway adenyl nucleotide binding adenyl ribonucleotide binding anion binding beta-adrenergic receptor kinase activity binding biological regulation biological_process carbohydrate derivative binding catalytic activity, acting on a protein catalytic activity cell projection cellular anatomical entity cellular process cellular_component cytosol desensitization of G protein-coupled receptor signaling pathway endocytosis establishment of localization heterocyclic compound binding import into cell ion binding kinase activity localization membrane molecular_function negative adaptation of signaling pathway negative regulation of G protein-coupled receptor signaling pathway negative regulation of biological process negative regulation of cell communication negative regulation of cellular process negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling nucleoside phosphate binding nucleotide binding organic cyclic compound binding phosphotransferase activity, alcohol group as acceptor plasma membrane postsynapse presynapse protein binding protein kinase activity protein serine/threonine kinase activity purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding receptor internalization receptor-mediated endocytosis regulation of G protein-coupled receptor signaling pathway regulation of biological process regulation of cell communication regulation of cellular process regulation of response to stimulus regulation of signal transduction regulation of signaling ribonucleotide binding signal transduction signaling receptor binding small molecule binding transferase activity, transferring phosphorus-containing groups transferase activity transport vesicle-mediated transport	GO:0000166 GO:0001664 GO:0002029 GO:0003674 GO:0003824 GO:0004672 GO:0004674 GO:0004703 GO:0005102 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005829 GO:0005886 GO:0006810 GO:0006897 GO:0006898 GO:0007165 GO:0007186 GO:0008150 GO:0008277 GO:0009966 GO:0009968 GO:0009987 GO:0010646 GO:0010648 GO:0016020 GO:0016192 GO:0016301 GO:0016740 GO:0016772 GO:0016773 GO:0017076 GO:0022401 GO:0023051 GO:0023057 GO:0023058 GO:0030554 GO:0031623 GO:0032553 GO:0032555 GO:0032559 GO:0035639 GO:0036094 GO:0042995 GO:0043167 GO:0043168 GO:0045744 GO:0047696 GO:0048519 GO:0048523 GO:0048583 GO:0048585 GO:0050789 GO:0050794 GO:0051179 GO:0051234 GO:0065007 GO:0097159 GO:0097367 GO:0098657 GO:0098793 GO:0098794 GO:0110165 GO:0140096 GO:1901265 GO:1901363
159	adenylosuccinate synthase 2	ADSS2	Homo sapiens (human)	9606			'de novo' AMP biosynthetic process AMP biosynthetic process AMP metabolic process GTP binding IMP metabolic process adenylosuccinate synthase activity alpha-amino acid metabolic process amino acid metabolic process anion binding aromatic compound biosynthetic process aspartate family amino acid metabolic process aspartate metabolic process binding biological_process biosynthetic process carbohydrate derivative binding carbohydrate derivative biosynthetic process carbohydrate derivative metabolic process carboxylic acid metabolic process catalytic activity cation binding cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular response to abiotic stimulus cellular response to electrical stimulus cellular response to environmental stimulus cellular response to stimulus cellular_component cytoplasm cytosol dicarboxylic acid metabolic process extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle guanyl nucleotide binding guanyl ribonucleotide binding heterocycle biosynthetic process heterocycle metabolic process heterocyclic compound binding immune system process intracellular membrane-bounded organelle intracellular organelle ion binding ligase activity, forming carbon-nitrogen bonds ligase activity magnesium ion binding membrane-bounded organelle metabolic process metal ion binding mitochondrion molecular_function nitrogen compound metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleoside monophosphate biosynthetic process nucleoside monophosphate metabolic process nucleoside phosphate binding nucleoside phosphate biosynthetic process nucleoside phosphate metabolic process nucleotide binding nucleotide biosynthetic process nucleotide metabolic process organelle organic acid metabolic process organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound biosynthetic process organonitrogen compound metabolic process organophosphate biosynthetic process organophosphate metabolic process oxoacid metabolic process phosphate ion binding phosphate-containing compound metabolic process phosphorus metabolic process primary metabolic process protein binding purine nucleoside monophosphate biosynthetic process purine nucleoside monophosphate metabolic process purine nucleotide binding purine nucleotide biosynthetic process purine nucleotide metabolic process purine ribonucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine ribonucleoside triphosphate binding purine ribonucleotide binding purine ribonucleotide biosynthetic process purine ribonucleotide metabolic process purine-containing compound biosynthetic process purine-containing compound metabolic process response to abiotic stimulus response to ammonium ion response to chemical response to electrical stimulus response to inorganic substance response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to purine-containing compound response to stimulus ribonucleoside monophosphate biosynthetic process ribonucleoside monophosphate metabolic process ribonucleotide binding ribonucleotide biosynthetic process ribonucleotide metabolic process ribose phosphate biosynthetic process ribose phosphate metabolic process small molecule binding small molecule metabolic process vesicle	GO:0000166 GO:0000287 GO:0002376 GO:0003674 GO:0003824 GO:0004019 GO:0005488 GO:0005515 GO:0005525 GO:0005575 GO:0005737 GO:0005739 GO:0005829 GO:0006082 GO:0006139 GO:0006163 GO:0006164 GO:0006167 GO:0006520 GO:0006531 GO:0006725 GO:0006753 GO:0006793 GO:0006796 GO:0006807 GO:0008150 GO:0008152 GO:0009058 GO:0009066 GO:0009117 GO:0009123 GO:0009124 GO:0009126 GO:0009127 GO:0009150 GO:0009152 GO:0009156 GO:0009161 GO:0009165 GO:0009167 GO:0009168 GO:0009259 GO:0009260 GO:0009628 GO:0009987 GO:0010033 GO:0010035 GO:0010243 GO:0014070 GO:0014074 GO:0016874 GO:0016879 GO:0017076 GO:0018130 GO:0019001 GO:0019438 GO:0019637 GO:0019693 GO:0019752 GO:0031982 GO:0032553 GO:0032555 GO:0032561 GO:0034641 GO:0034654 GO:0035639 GO:0036094 GO:0042221 GO:0042301 GO:0043167 GO:0043168 GO:0043169 GO:0043226 GO:0043227 GO:0043229 GO:0043230 GO:0043231 GO:0043436 GO:0043648 GO:0044208 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0044281 GO:0046033 GO:0046040 GO:0046390 GO:0046483 GO:0046872 GO:0050896 GO:0051602 GO:0051716 GO:0055086 GO:0060359 GO:0065010 GO:0070062 GO:0071214 GO:0071257 GO:0071704 GO:0072521 GO:0072522 GO:0090407 GO:0097159 GO:0097367 GO:0104004 GO:0110165 GO:1901135 GO:1901137 GO:1901265 GO:1901293 GO:1901360 GO:1901362 GO:1901363 GO:1901564 GO:1901566 GO:1901576 GO:1901605 GO:1901698 GO:1903561
160	adaptor related protein complex 2 subunit alpha 1	AP2A1	Homo sapiens (human)	9606			AP-2 adaptor complex AP-type membrane coat adaptor complex Golgi to endosome transport Golgi vesicle transport apical plasma membrane basolateral plasma membrane binding biological regulation biological_process bounding membrane of organelle cargo adaptor activity cell junction cellular anatomical entity cellular localization cellular macromolecule localization cellular process cellular_component clathrin adaptor activity clathrin adaptor complex clathrin coat of trans-Golgi network vesicle clathrin coat clathrin vesicle coat clathrin-coated endocytic vesicle membrane clathrin-coated endocytic vesicle clathrin-coated vesicle membrane clathrin-coated vesicle clathrin-dependent endocytosis coated vesicle membrane coated vesicle cytoplasmic side of membrane cytoplasmic side of plasma membrane cytoplasmic vesicle membrane cytoplasmic vesicle cytosol cytosolic transport endocytic vesicle membrane endocytic vesicle endocytosis endolysosome membrane endosome membrane enzyme binding establishment of localization in cell establishment of localization establishment of protein localization exocytic vesicle filopodium tip glutamatergic synapse import into cell intracellular membrane-bounded organelle intracellular organelle intracellular protein transport intracellular transport intracellular vesicle kinase binding lipoprotein particle receptor binding localization low-density lipoprotein particle receptor binding lysosomal membrane lytic vacuole membrane macromolecule localization membrane coat membrane protein complex membrane-bounded organelle membrane molecular adaptor activity molecular_function negative regulation of biological process negative regulation of biosynthetic process negative regulation of carbohydrate metabolic process negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of hyaluronan biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of nitrogen compound metabolic process neurotransmitter receptor internalization nitrogen compound transport organelle membrane organelle organic substance transport plasma membrane protein complex plasma membrane region plasma membrane positive regulation of biological process positive regulation of cell projection organization positive regulation of cellular component organization positive regulation of cellular process positive regulation of endocytosis positive regulation of neuron projection development positive regulation of receptor-mediated endocytosis positive regulation of transport post-Golgi vesicle-mediated transport postsynaptic endocytic zone postsynaptic endocytosis postsynaptic neurotransmitter receptor internalization presynaptic endocytosis protein binding protein kinase binding protein localization protein transport protein-containing complex binding protein-containing complex localization protein-containing complex protein-macromolecule adaptor activity receptor internalization receptor-mediated endocytosis regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of carbohydrate biosynthetic process regulation of carbohydrate metabolic process regulation of cell projection organization regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of endocytosis regulation of hyaluronan biosynthetic process regulation of localization regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of neuron projection development regulation of nitrogen compound metabolic process regulation of plasma membrane bounded cell projection organization regulation of polysaccharide biosynthetic process regulation of polysaccharide metabolic process regulation of postsynaptic membrane neurotransmitter receptor levels regulation of primary metabolic process regulation of receptor-mediated endocytosis regulation of transport regulation of vesicle-mediated transport secretory vesicle side of membrane signaling receptor binding synapse synaptic vesicle endocytosis synaptic vesicle transport vesicle transport vacuolar membrane vesicle coat vesicle membrane vesicle-mediated transport in synapse vesicle-mediated transport vesicle	GO:0003674 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005765 GO:0005774 GO:0005829 GO:0005886 GO:0006109 GO:0006810 GO:0006886 GO:0006892 GO:0006895 GO:0006897 GO:0006898 GO:0008021 GO:0008104 GO:0008150 GO:0009889 GO:0009890 GO:0009892 GO:0009898 GO:0009987 GO:0010008 GO:0010556 GO:0010558 GO:0010605 GO:0010975 GO:0010976 GO:0012506 GO:0015031 GO:0016020 GO:0016192 GO:0016323 GO:0016324 GO:0016482 GO:0019222 GO:0019899 GO:0019900 GO:0019901 GO:0030054 GO:0030100 GO:0030117 GO:0030118 GO:0030119 GO:0030120 GO:0030122 GO:0030125 GO:0030130 GO:0030131 GO:0030133 GO:0030135 GO:0030136 GO:0030139 GO:0030659 GO:0030662 GO:0030665 GO:0030666 GO:0030669 GO:0030674 GO:0031090 GO:0031323 GO:0031324 GO:0031326 GO:0031327 GO:0031344 GO:0031346 GO:0031410 GO:0031503 GO:0031623 GO:0031982 GO:0032433 GO:0032879 GO:0032881 GO:0032885 GO:0032991 GO:0033036 GO:0035615 GO:0036020 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043255 GO:0044877 GO:0045184 GO:0045202 GO:0045334 GO:0045807 GO:0045912 GO:0046907 GO:0048193 GO:0048259 GO:0048260 GO:0048488 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0050750 GO:0050789 GO:0050794 GO:0051049 GO:0051050 GO:0051128 GO:0051130 GO:0051171 GO:0051172 GO:0051179 GO:0051234 GO:0051641 GO:0051649 GO:0060090 GO:0060255 GO:0060627 GO:0065007 GO:0065008 GO:0070325 GO:0070382 GO:0070727 GO:0071702 GO:0071705 GO:0072583 GO:0080090 GO:0097708 GO:0098552 GO:0098562 GO:0098588 GO:0098590 GO:0098657 GO:0098796 GO:0098797 GO:0098843 GO:0098852 GO:0098884 GO:0098978 GO:0099003 GO:0099072 GO:0099503 GO:0099590 GO:0110165 GO:0120035 GO:0140238 GO:0140239 GO:0140312 GO:1900125 GO:1900126
161	adaptor related protein complex 2 subunit alpha 2	AP2A2	Homo sapiens (human)	9606			AP-2 adaptor complex AP-type membrane coat adaptor complex binding biological regulation biological_process bounding membrane of organelle cargo adaptor activity cellular anatomical entity cellular localization cellular macromolecule localization cellular process cellular_component clathrin adaptor activity clathrin adaptor complex clathrin-coated endocytic vesicle membrane clathrin-coated endocytic vesicle clathrin-coated vesicle membrane clathrin-coated vesicle clathrin-dependent endocytosis coated vesicle membrane coated vesicle cytoplasmic side of membrane cytoplasmic side of plasma membrane cytoplasmic vesicle membrane cytoplasmic vesicle cytosol disordered domain specific binding endocytic vesicle membrane endocytic vesicle endocytosis endolysosome membrane endosome membrane enzyme binding establishment of localization in cell establishment of localization establishment of protein localization ficolin-1-rich granule membrane import into cell intracellular membrane-bounded organelle intracellular organelle intracellular protein transport intracellular transport intracellular vesicle kinase binding lipid binding localization lysosomal membrane lytic vacuole membrane macromolecule localization membrane protein complex membrane-bounded organelle membrane molecular adaptor activity molecular_function neurotransmitter receptor internalization nitrogen compound transport organelle membrane organelle organic substance transport plasma membrane protein complex plasma membrane postsynapse postsynaptic endocytosis postsynaptic neurotransmitter receptor internalization presynapse presynaptic endocytosis protein binding protein domain specific binding protein kinase binding protein localization protein transport protein-containing complex localization protein-containing complex protein-macromolecule adaptor activity receptor internalization receptor-mediated endocytosis regulation of biological quality regulation of postsynaptic membrane neurotransmitter receptor levels secretory granule membrane side of membrane synaptic vesicle endocytosis transport vacuolar membrane vesicle membrane vesicle-mediated transport in synapse vesicle-mediated transport vesicle	GO:0003674 GO:0005488 GO:0005515 GO:0005575 GO:0005765 GO:0005774 GO:0005829 GO:0005886 GO:0006810 GO:0006886 GO:0006897 GO:0006898 GO:0008104 GO:0008150 GO:0008289 GO:0009898 GO:0009987 GO:0010008 GO:0012506 GO:0015031 GO:0016020 GO:0016192 GO:0019899 GO:0019900 GO:0019901 GO:0019904 GO:0030119 GO:0030122 GO:0030131 GO:0030135 GO:0030136 GO:0030139 GO:0030659 GO:0030662 GO:0030665 GO:0030666 GO:0030667 GO:0030669 GO:0030674 GO:0031090 GO:0031410 GO:0031503 GO:0031623 GO:0031982 GO:0032991 GO:0033036 GO:0035615 GO:0036020 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0045184 GO:0045334 GO:0046907 GO:0048488 GO:0051179 GO:0051234 GO:0051641 GO:0051649 GO:0060090 GO:0065007 GO:0065008 GO:0070727 GO:0071702 GO:0071705 GO:0072583 GO:0097708 GO:0097718 GO:0098552 GO:0098562 GO:0098588 GO:0098657 GO:0098793 GO:0098794 GO:0098796 GO:0098797 GO:0098852 GO:0098884 GO:0099003 GO:0099072 GO:0099590 GO:0101003 GO:0110165 GO:0140238 GO:0140239 GO:0140312
163	adaptor related protein complex 2 subunit beta 1	AP2B1	Homo sapiens (human)	9606			AP-2 adaptor complex AP-type membrane coat adaptor complex amide binding anatomical structure development animal organ development aorta development artery development binding biological regulation biological_process blood vessel development bounding membrane of organelle cardiac septum development cargo adaptor activity cell junction cellular anatomical entity cellular localization cellular macromolecule localization cellular process cellular_component clathrin adaptor activity clathrin adaptor complex clathrin binding clathrin-coated endocytic vesicle membrane clathrin-coated endocytic vesicle clathrin-coated vesicle membrane clathrin-coated vesicle clathrin-dependent endocytosis coated vesicle membrane coated vesicle coronary vasculature development cytoplasmic side of membrane cytoplasmic side of plasma membrane cytoplasmic vesicle membrane cytoplasmic vesicle cytosol developmental process endocytic vesicle membrane endocytic vesicle endocytosis endolysosome membrane endosome membrane establishment of localization in cell establishment of localization establishment of protein localization glutamatergic synapse import into cell intracellular membrane-bounded organelle intracellular organelle intracellular protein transport intracellular transport intracellular vesicle kidney development localization lysosomal membrane lytic vacuole membrane macromolecule localization membrane protein complex membrane-bounded organelle membrane molecular adaptor activity molecular_function neurotransmitter receptor internalization nitrogen compound transport organelle membrane organelle organic substance transport peptide binding plasma membrane protein complex plasma membrane postsynapse postsynaptic endocytosis postsynaptic neurotransmitter receptor internalization presynapse presynaptic endocytosis protein binding protein localization protein transport protein-containing complex localization protein-containing complex protein-macromolecule adaptor activity receptor internalization receptor-mediated endocytosis regulation of biological quality regulation of postsynaptic membrane neurotransmitter receptor levels side of membrane signal sequence binding synapse synaptic vesicle endocytosis transport vacuolar membrane ventricular septum development vesicle membrane vesicle-mediated transport in synapse vesicle-mediated transport vesicle	GO:0001568 GO:0001822 GO:0003279 GO:0003281 GO:0003674 GO:0005048 GO:0005488 GO:0005515 GO:0005575 GO:0005765 GO:0005774 GO:0005829 GO:0005886 GO:0006810 GO:0006886 GO:0006897 GO:0006898 GO:0008104 GO:0008150 GO:0009898 GO:0009987 GO:0010008 GO:0012506 GO:0015031 GO:0016020 GO:0016192 GO:0030054 GO:0030119 GO:0030122 GO:0030131 GO:0030135 GO:0030136 GO:0030139 GO:0030276 GO:0030659 GO:0030662 GO:0030665 GO:0030666 GO:0030669 GO:0030674 GO:0031090 GO:0031410 GO:0031503 GO:0031623 GO:0031982 GO:0032502 GO:0032991 GO:0033036 GO:0033218 GO:0035615 GO:0035904 GO:0036020 GO:0042277 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0045184 GO:0045202 GO:0045334 GO:0046907 GO:0048488 GO:0048513 GO:0048856 GO:0051179 GO:0051234 GO:0051641 GO:0051649 GO:0060090 GO:0060840 GO:0060976 GO:0065007 GO:0065008 GO:0070727 GO:0071702 GO:0071705 GO:0072583 GO:0097708 GO:0098552 GO:0098562 GO:0098588 GO:0098657 GO:0098793 GO:0098794 GO:0098796 GO:0098797 GO:0098852 GO:0098884 GO:0098978 GO:0099003 GO:0099072 GO:0099590 GO:0110165 GO:0140238 GO:0140239 GO:0140312
165	AE binding protein 1	AEBP1	Homo sapiens (human)	9606	Ehlers-Danlos syndrome classic-like 2	DOID:0080732	DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding amide metabolic process binding biological regulation biological_process calmodulin binding carboxypeptidase activity catalytic activity, acting on a protein catalytic activity cation binding cellular anatomical entity cellular_component collagen binding collagen-containing extracellular matrix cytoplasm double-stranded DNA binding exopeptidase activity external encapsulating structure extracellular exosome extracellular matrix structural constituent extracellular matrix extracellular membrane-bounded organelle extracellular organelle extracellular region extracellular space extracellular vesicle hydrolase activity intracellular membrane-bounded organelle intracellular organelle ion binding macromolecule metabolic process membrane-bounded organelle metabolic process metal ion binding metallocarboxypeptidase activity metalloexopeptidase activity metallopeptidase activity molecular_function negative regulation of DNA-templated transcription negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of biological process negative regulation of biosynthetic process negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of transcription by RNA polymerase II nitrogen compound metabolic process nucleic acid binding nucleus organelle organic cyclic compound binding organic substance metabolic process organonitrogen compound metabolic process peptidase activity peptide metabolic process primary metabolic process protein binding protein maturation protein metabolic process protein processing protein-containing complex binding proteolysis regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of biological process regulation of biosynthetic process regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of collagen fibril organization regulation of extracellular matrix organization regulation of gene expression regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of primary metabolic process regulation of supramolecular fiber organization regulation of transcription by RNA polymerase II sequence-specific DNA binding sequence-specific double-stranded DNA binding structural molecule activity transcription cis-regulatory region binding transcription regulator activity transcription regulatory region nucleic acid binding transition metal ion binding vesicle zinc ion binding	GO:0000122 GO:0000976 GO:0000977 GO:0000981 GO:0001067 GO:0001217 GO:0001227 GO:0003674 GO:0003676 GO:0003677 GO:0003690 GO:0003700 GO:0003824 GO:0004180 GO:0004181 GO:0005198 GO:0005201 GO:0005488 GO:0005515 GO:0005516 GO:0005518 GO:0005575 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0006355 GO:0006357 GO:0006508 GO:0006518 GO:0006807 GO:0008150 GO:0008152 GO:0008233 GO:0008235 GO:0008237 GO:0008238 GO:0008270 GO:0009889 GO:0009890 GO:0009892 GO:0010468 GO:0010556 GO:0010558 GO:0010605 GO:0016485 GO:0016787 GO:0019219 GO:0019222 GO:0019538 GO:0030312 GO:0031012 GO:0031323 GO:0031324 GO:0031326 GO:0031327 GO:0031982 GO:0043167 GO:0043169 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043230 GO:0043231 GO:0043565 GO:0043603 GO:0044238 GO:0044877 GO:0045892 GO:0045934 GO:0046872 GO:0046914 GO:0048519 GO:0048523 GO:0050789 GO:0050794 GO:0051128 GO:0051171 GO:0051172 GO:0051252 GO:0051253 GO:0051604 GO:0060255 GO:0062023 GO:0065007 GO:0065010 GO:0070062 GO:0071704 GO:0080090 GO:0097159 GO:0110165 GO:0140096 GO:0140110 GO:1901564 GO:1902679 GO:1902903 GO:1903053 GO:1903561 GO:1904026 GO:1990837 GO:2001141

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