GlyCosmos Portal

GlyCosmos Genes

Integrated list of glycan-related genes extracted KEGG GENES Database, UniProt, GlycoGene Database (GGDB), Plant GARDEN and FlyGlycoDB. Glycan-related genes including glycosyltransferase, hydrolase activity (acting on glycosyl bonds), carbohydrate metabolic process, etc .

Source	Last Updated
FlyGlycoDB	March 25, 2024
GlycoGene Database (GGDB)	January 26, 2018
KEGG GENES Database	September 20, 2023
Plant GARDEN	May 28, 2020
UniProt	October 29, 2024

Selecting the function you want to look up from the categories displays a list narrowed down to glycan-related genes with that function (Gene Ontology).

Catalytic activity

glycosyltransferase activity

hydrolase activity, acting on glycosyl bonds

Binding

carbohydrate binding

Response to carbohydrate

Primary metabolic process

Displaying entries **76 - 100** of **9988** in total

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Gene ID ▲	Gene Name	Gene Symbol	Organism	Taxonomy ID	Disease Ontology	Disease Ontology ID	Gene Ontology	Gene Ontology ID
130	alcohol dehydrogenase 6 (class V)	ADH6 Aliases: ADH-5	Homo sapiens (human)	9606	alcohol dependence alcohol use disorder anaplastic astrocytoma cancer childhood cerebral astrocytoma embryoma fibrillary astrocytoma gemistocytic astrocytoma hepatocellular carcinoma high grade glioma juvenile pilocytic astrocytoma liver cancer malignant astrocytoma pancreatic cancer pancreatic carcinoma pilocytic astrocytoma protoplasmic astrocytoma stomach cancer stomach carcinoma subependymal giant cell astrocytoma	DOID:0050741 DOID:10534 DOID:1574 DOID:162 DOID:1793 DOID:3069 DOID:3070 DOID:3078 DOID:3571 DOID:4766 DOID:4851 DOID:4905 DOID:5077 DOID:5517 DOID:6726 DOID:6811 DOID:684 DOID:7005 DOID:7007 DOID:7008	NAD-retinol dehydrogenase activity alcohol dehydrogenase (NAD+) activity alcohol dehydrogenase [NAD(P)+] activity alcohol dehydrogenase activity, zinc-dependent alcohol metabolic process binding biological regulation biological_process carboxylic acid metabolic process catalytic activity cation binding cellular anatomical entity cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytosol diterpenoid metabolic process extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle hormone metabolic process ion binding isoprenoid metabolic process lipid metabolic process membrane-bounded organelle metabolic process metal ion binding molecular_function monocarboxylic acid metabolic process olefinic compound metabolic process organelle organic acid metabolic process organic hydroxy compound metabolic process organic substance metabolic process oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity oxoacid metabolic process primary alcohol metabolic process primary metabolic process regulation of biological quality regulation of hormone levels retinoic acid metabolic process retinoid metabolic process retinol metabolic process small molecule metabolic process terpenoid metabolic process transition metal ion binding vesicle zinc ion binding	GO:0001523 GO:0003674 GO:0003824 GO:0004022 GO:0004024 GO:0004745 GO:0005488 GO:0005575 GO:0005829 GO:0006066 GO:0006082 GO:0006629 GO:0006720 GO:0006721 GO:0008150 GO:0008152 GO:0008270 GO:0009987 GO:0010817 GO:0016101 GO:0016491 GO:0016614 GO:0016616 GO:0018455 GO:0019752 GO:0031982 GO:0032787 GO:0034308 GO:0042445 GO:0042572 GO:0042573 GO:0043167 GO:0043169 GO:0043226 GO:0043227 GO:0043230 GO:0043436 GO:0044237 GO:0044238 GO:0044255 GO:0044281 GO:0046872 GO:0046914 GO:0065007 GO:0065008 GO:0065010 GO:0070062 GO:0071704 GO:0110165 GO:0120254 GO:1901615 GO:1903561
131	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	ADH7 Aliases: ADH-4	Homo sapiens (human)	9606	Leber congenital amaurosis Parkinson's disease 19A Parkinson's disease 23 Parkinson's disease 4 Parkinson's disease adenocarcinoma adenoma alcohol dependence alcohol use disorder aniridia cancer chromophobe renal cell carcinoma clear cell renal cell carcinoma collecting duct carcinoma colorectal cancer colorectal carcinoma cone-rod dystrophy cribriform carcinoma embryoma endometrial cancer endometrial carcinoma esophageal cancer esophageal carcinoma esophagus squamous cell carcinoma fundus albipunctatus fundus dystrophy granular cell carcinoma head and neck cancer head and neck squamous cell carcinoma large intestine cancer laryngeal benign neoplasm laryngeal carcinoma larynx cancer lung cancer lung non-small cell carcinoma nicotine dependence nonpapillary renal cell carcinoma papillary renal cell carcinoma pharynx cancer renal carcinoma renal cell carcinoma retinitis pigmentosa sarcomatoid renal cell carcinoma squamous cell carcinoma squamous cell neoplasm stomach cancer stomach carcinoma substance abuse substance-related disorder tongue squamous cell carcinoma tubular adenocarcinoma uterine corpus cancer	DOID:0050387 DOID:0050572 DOID:0050741 DOID:0050742 DOID:0050865 DOID:0060119 DOID:0060891 DOID:0060895 DOID:0060896 DOID:0080199 DOID:10534 DOID:10584 DOID:1107 DOID:11105 DOID:11934 DOID:12271 DOID:1324 DOID:1380 DOID:14330 DOID:14791 DOID:1574 DOID:162 DOID:1749 DOID:2596 DOID:2598 DOID:2600 DOID:2871 DOID:299 DOID:302 DOID:303 DOID:3168 DOID:3748 DOID:3908 DOID:4450 DOID:4451 DOID:4464 DOID:4465 DOID:4467 DOID:4471 DOID:4473 DOID:4766 DOID:4903 DOID:4929 DOID:5041 DOID:5517 DOID:5520 DOID:5672 DOID:5675 DOID:657 DOID:8501 DOID:9256 DOID:9460	NAD-retinol dehydrogenase activity alcohol binding alcohol dehydrogenase (NAD+) activity alcohol dehydrogenase [NAD(P)+] activity alcohol metabolic process aldehyde oxidase activity binding biological process involved in interspecies interaction between organisms biological regulation biological_process carboxylic acid metabolic process catalytic activity cation binding cellular anatomical entity cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytosol diterpenoid metabolic process ethanol binding fatty acid metabolic process fatty acid omega-oxidation fatty acid oxidation hormone metabolic process ion binding isoprenoid binding isoprenoid metabolic process lipid binding lipid metabolic process lipid modification lipid oxidation membrane metabolic process metal ion binding molecular function inhibitor activity molecular function regulator activity molecular_function monocarboxylic acid metabolic process olefinic compound metabolic process omega-hydroxydecanoate dehydrogenase activity organic acid metabolic process organic hydroxy compound metabolic process organic substance metabolic process oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor oxidoreductase activity, acting on the aldehyde or oxo group of donors oxidoreductase activity oxoacid metabolic process plasma membrane primary alcohol metabolic process primary metabolic process protein binding receptor antagonist activity regulation of biological quality regulation of hormone levels response to alcohol response to bacterium response to biotic stimulus response to chemical response to ethanol response to external biotic stimulus response to external stimulus response to organic substance response to other organism response to oxygen-containing compound response to stimulus retinoic acid metabolic process retinoid binding retinoid metabolic process retinol binding retinol metabolic process signaling receptor binding signaling receptor inhibitor activity signaling receptor regulator activity small molecule binding small molecule metabolic process terpenoid metabolic process transition metal ion binding vitamin binding zinc ion binding	GO:0001523 GO:0003674 GO:0003824 GO:0004022 GO:0004031 GO:0004745 GO:0005102 GO:0005488 GO:0005501 GO:0005515 GO:0005575 GO:0005829 GO:0005886 GO:0006066 GO:0006082 GO:0006629 GO:0006631 GO:0006720 GO:0006721 GO:0008150 GO:0008152 GO:0008270 GO:0008289 GO:0009605 GO:0009607 GO:0009617 GO:0009987 GO:0010033 GO:0010430 GO:0010817 GO:0016020 GO:0016101 GO:0016491 GO:0016614 GO:0016616 GO:0016623 GO:0016903 GO:0018455 GO:0019395 GO:0019752 GO:0019840 GO:0019841 GO:0019842 GO:0030258 GO:0030545 GO:0030547 GO:0032787 GO:0034308 GO:0034440 GO:0035276 GO:0036094 GO:0042221 GO:0042445 GO:0042572 GO:0042573 GO:0043167 GO:0043169 GO:0043178 GO:0043207 GO:0043436 GO:0044237 GO:0044238 GO:0044255 GO:0044281 GO:0044419 GO:0045471 GO:0046872 GO:0046914 GO:0048019 GO:0050153 GO:0050896 GO:0051707 GO:0065007 GO:0065008 GO:0071704 GO:0097305 GO:0098772 GO:0110165 GO:0120254 GO:0140678 GO:1901615 GO:1901700
133	adrenomedullin	ADM	Homo sapiens (human)	9606			G protein-coupled receptor binding G protein-coupled receptor internalization G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenomedullin receptor binding adrenomedullin receptor signaling pathway anatomical structure development anatomical structure formation involved in morphogenesis anatomical structure morphogenesis androgen metabolic process animal organ development animal organ morphogenesis animal organ regeneration antibacterial humoral response antifungal humoral response antimicrobial humoral immune response mediated by antimicrobial peptide antimicrobial humoral response binding biological process involved in interspecies interaction between organisms biological regulation biological_process blood vessel diameter maintenance branching involved in labyrinthine layer morphogenesis cAMP-mediated signaling calcitonin family receptor signaling pathway cell development cell differentiation cell population proliferation cell projection organization cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular developmental process cellular process cellular response to stimulus cellular response to stress cellular_component circulatory system process cyclic-nucleotide-mediated signaling cytoplasm defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to bacterium defense response to fungus defense response to other organism defense response developmental growth developmental process embryonic morphogenesis endocytosis establishment of localization extracellular region extracellular space female pregnancy growth heart development hormone activity hormone metabolic process humoral immune response immune response immune system process import into cell inflammatory response intracellular signal transduction lipid metabolic process localization metabolic process molecular function activator activity molecular function regulator activity molecular_function morphogenesis of a branching epithelium morphogenesis of a branching structure morphogenesis of an epithelium multi-multicellular organism process multi-organism reproductive process multicellular organismal process muscle cell development negative regulation of biological process negative regulation of cell population proliferation negative regulation of cellular process negative regulation of multicellular organismal process negative regulation of vascular permeability negative regulation of vasoconstriction neural tube closure neuron projection development neuron projection regeneration odontogenesis of dentin-containing tooth odontogenesis organic cyclic compound metabolic process organic substance metabolic process plasma membrane bounded cell projection organization positive regulation of angiogenesis positive regulation of apoptotic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of blood circulation positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytosolic calcium ion concentration positive regulation of developmental process positive regulation of heart contraction positive regulation of heart rate positive regulation of hormone biosynthetic process positive regulation of hormone metabolic process positive regulation of lipid biosynthetic process positive regulation of lipid metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of progesterone biosynthetic process positive regulation of programmed cell death positive regulation of small molecule metabolic process positive regulation of steroid biosynthetic process positive regulation of steroid metabolic process positive regulation of vasculature development positive regulation of vasculogenesis primary metabolic process protein binding receptor internalization receptor ligand activity receptor-mediated endocytosis regeneration regulation of anatomical structure morphogenesis regulation of anatomical structure size regulation of angiogenesis regulation of apoptotic process regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of blood circulation regulation of blood pressure regulation of body fluid levels regulation of cell differentiation regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular ketone metabolic process regulation of cellular metabolic process regulation of cellular process regulation of developmental process regulation of heart contraction regulation of heart rate regulation of hormone biosynthetic process regulation of hormone levels regulation of hormone metabolic process regulation of ketone biosynthetic process regulation of lipid biosynthetic process regulation of lipid metabolic process regulation of metabolic process regulation of multicellular organismal development regulation of multicellular organismal process regulation of primary metabolic process regulation of progesterone biosynthetic process regulation of programmed cell death regulation of small molecule metabolic process regulation of steroid biosynthetic process regulation of steroid metabolic process regulation of system process regulation of systemic arterial blood pressure regulation of the force of heart contraction regulation of tube diameter regulation of tube size regulation of urine volume regulation of vascular permeability regulation of vasculature development regulation of vasculogenesis regulation of vasoconstriction renal system process reproductive process response to abiotic stimulus response to bacterium response to biotic stimulus response to chemical response to corticosteroid response to decreased oxygen levels response to endogenous stimulus response to ether response to external biotic stimulus response to external stimulus response to extracellular stimulus response to fungus response to glucocorticoid response to hormone response to hypoxia response to insulin response to lipid response to lipopolysaccharide response to molecule of bacterial origin response to nitrogen compound response to nutrient levels response to organic cyclic compound response to organic substance response to organonitrogen compound response to other organism response to oxygen levels response to oxygen-containing compound response to peptide hormone response to peptide response to starvation response to steroid hormone response to stimulus response to stress response to yeast second-messenger-mediated signaling signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity spongiotrophoblast layer development steroid metabolic process system process tissue development tissue morphogenesis transport tube closure tube formation vascular associated smooth muscle cell development vascular process in circulatory system vasculogenesis vesicle-mediated transport	GO:0001570 GO:0001664 GO:0001666 GO:0001763 GO:0001843 GO:0001878 GO:0002009 GO:0002026 GO:0002027 GO:0002031 GO:0002237 GO:0002376 GO:0003008 GO:0003013 GO:0003014 GO:0003018 GO:0003073 GO:0003674 GO:0005102 GO:0005179 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0005737 GO:0006629 GO:0006810 GO:0006897 GO:0006898 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0006959 GO:0007165 GO:0007186 GO:0007188 GO:0007189 GO:0007204 GO:0007507 GO:0007565 GO:0008016 GO:0008150 GO:0008152 GO:0008202 GO:0008209 GO:0008217 GO:0008283 GO:0008284 GO:0008285 GO:0009605 GO:0009607 GO:0009617 GO:0009620 GO:0009628 GO:0009653 GO:0009719 GO:0009725 GO:0009887 GO:0009888 GO:0009889 GO:0009891 GO:0009893 GO:0009987 GO:0009991 GO:0010033 GO:0010243 GO:0010460 GO:0010565 GO:0010566 GO:0010817 GO:0010893 GO:0014070 GO:0016043 GO:0016192 GO:0019216 GO:0019218 GO:0019222 GO:0019229 GO:0019730 GO:0019731 GO:0019732 GO:0019932 GO:0019933 GO:0019935 GO:0022414 GO:0022603 GO:0030030 GO:0030154 GO:0030545 GO:0030546 GO:0031099 GO:0031100 GO:0031102 GO:0031175 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031623 GO:0031667 GO:0031700 GO:0031960 GO:0032350 GO:0032352 GO:0032496 GO:0032501 GO:0032502 GO:0032868 GO:0033554 GO:0033993 GO:0035148 GO:0035150 GO:0035296 GO:0035556 GO:0035809 GO:0036293 GO:0040007 GO:0042127 GO:0042221 GO:0042445 GO:0042475 GO:0042476 GO:0042594 GO:0042742 GO:0042981 GO:0043065 GO:0043067 GO:0043068 GO:0043114 GO:0043116 GO:0043207 GO:0043434 GO:0044057 GO:0044238 GO:0044419 GO:0044703 GO:0044706 GO:0045472 GO:0045595 GO:0045597 GO:0045765 GO:0045766 GO:0045823 GO:0045834 GO:0045906 GO:0045940 GO:0046885 GO:0046886 GO:0046889 GO:0046890 GO:0048018 GO:0048468 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048545 GO:0048589 GO:0048598 GO:0048646 GO:0048729 GO:0048856 GO:0048869 GO:0050789 GO:0050793 GO:0050794 GO:0050810 GO:0050829 GO:0050830 GO:0050832 GO:0050878 GO:0050896 GO:0051094 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051384 GO:0051707 GO:0051716 GO:0055001 GO:0060606 GO:0060670 GO:0060712 GO:0061138 GO:0061844 GO:0062012 GO:0062013 GO:0065007 GO:0065008 GO:0070482 GO:0071704 GO:0071840 GO:0080090 GO:0090066 GO:0097084 GO:0097646 GO:0097746 GO:0098542 GO:0098657 GO:0098772 GO:0110165 GO:0120036 GO:0140677 GO:1901342 GO:1901360 GO:1901652 GO:1901698 GO:1901700 GO:1903522 GO:1903524 GO:1904018 GO:1990410 GO:2000026 GO:2000182 GO:2000184 GO:2001212 GO:2001214
134	adenosine A1 receptor	ADORA1	Homo sapiens (human)	9606			G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor signaling pathway G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor activity G protein-coupled receptor binding G protein-coupled receptor signaling pathway G-protein beta/gamma-subunit complex binding acylglycerol homeostasis adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway anatomical structure development apoptotic signaling pathway asymmetric synapse axolemma axon terminus basolateral plasma membrane binding biological regulation biological_process blood vessel diameter maintenance body fluid secretion calcium ion homeostasis calyx of Held carbohydrate derivative binding catabolic process cell body cell communication cell junction cell migration cell motility cell projection membrane cell projection cell surface receptor signaling pathway cell-cell signaling cellular anatomical entity cellular homeostasis cellular localization cellular macromolecule localization cellular process cellular_component chemical homeostasis circulatory system process cognition defense response dendrite dendritic spine detection of abiotic stimulus detection of external stimulus detection of stimulus involved in sensory perception of pain detection of stimulus involved in sensory perception detection of stimulus detection of temperature stimulus involved in sensory perception of pain detection of temperature stimulus involved in sensory perception detection of temperature stimulus developmental process endocytosis establishment of localization establishment of protein localization to membrane establishment of protein localization excitatory postsynaptic potential fatty acid homeostasis heat shock protein binding heterocyclic compound binding heterotrimeric G-protein binding homeostatic process immune system process import into cell inflammatory response inorganic ion homeostasis intracellular calcium ion homeostasis intracellular chemical homeostasis intracellular monoatomic cation homeostasis intracellular monoatomic ion homeostasis leading edge membrane leukocyte migration lipid catabolic process lipid homeostasis lipid metabolic process localization within membrane localization long-term synaptic depression macromolecule localization membrane metabolic process modulation of chemical synaptic transmission molecular transducer activity molecular_function monoatomic cation homeostasis monoatomic ion homeostasis mucus secretion multicellular organismal process multicellular organismal-level homeostasis negative regulation of acute inflammatory response negative regulation of amine transport negative regulation of amino acid transport negative regulation of apoptotic process negative regulation of behavior negative regulation of biological process negative regulation of blood pressure negative regulation of catabolic process negative regulation of cell communication negative regulation of cell migration negative regulation of cell motility negative regulation of cell population proliferation negative regulation of cellular process negative regulation of circadian rhythm negative regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of circadian sleep/wake cycle, sleep negative regulation of defense response negative regulation of glutamate secretion negative regulation of hormone secretion negative regulation of immune system process negative regulation of inflammatory response negative regulation of leukocyte migration negative regulation of lipid catabolic process negative regulation of lipid metabolic process negative regulation of locomotion negative regulation of long-term synaptic depression negative regulation of long-term synaptic potentiation negative regulation of metabolic process negative regulation of mucus secretion negative regulation of multicellular organismal process negative regulation of neurotrophin production negative regulation of organic acid transport negative regulation of programmed cell death negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of secretion by cell negative regulation of secretion negative regulation of signaling negative regulation of synaptic transmission, GABAergic negative regulation of synaptic transmission, glutamatergic negative regulation of synaptic transmission negative regulation of systemic arterial blood pressure negative regulation of transport nervous system development nervous system process neuron cellular homeostasis neuron projection membrane neuron projection terminus neuron projection neuron spine neuron to neuron synapse neuronal cell body nucleoside binding organic cyclic compound binding organic substance catabolic process organic substance metabolic process phagocytosis plasma membrane bounded cell projection plasma membrane region plasma membrane positive regulation of MAPK cascade positive regulation of biological process positive regulation of blood pressure positive regulation of catabolic process positive regulation of cell communication positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of dephosphorylation positive regulation of intracellular signal transduction positive regulation of lipid catabolic process positive regulation of lipid metabolic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of monoatomic ion transport positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound transport positive regulation of nucleoside transport positive regulation of peptide secretion positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of potassium ion transport positive regulation of protein dephosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of response to stimulus positive regulation of secretion positive regulation of signal transduction positive regulation of signaling positive regulation of synaptic transmission positive regulation of systemic arterial blood pressure positive regulation of transport postsynapse postsynaptic membrane presynapse presynaptic active zone presynaptic membrane primary metabolic process protein binding protein dimerization activity protein heterodimerization activity protein localization to membrane protein localization protein targeting to membrane protein targeting protein-containing complex binding purine nucleoside binding purinergic nucleotide receptor signaling pathway regulation of MAPK cascade regulation of actin filament-based movement regulation of actin filament-based process regulation of acute inflammatory response regulation of amine transport regulation of amino acid transport regulation of anatomical structure size regulation of apoptotic process regulation of behavior regulation of biological process regulation of biological quality regulation of blood circulation regulation of blood pressure regulation of body fluid levels regulation of cardiac muscle cell contraction regulation of cardiac muscle contraction regulation of catabolic process regulation of cell communication regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cellular metabolic process regulation of cellular process regulation of circadian rhythm regulation of circadian sleep/wake cycle, non-REM sleep regulation of circadian sleep/wake cycle, sleep regulation of circadian sleep/wake cycle regulation of cytosolic calcium ion concentration regulation of defense response regulation of dephosphorylation regulation of glomerular filtration regulation of glutamate secretion regulation of heart contraction regulation of hormone levels regulation of hormone secretion regulation of immune system process regulation of inflammatory response regulation of intracellular signal transduction regulation of leukocyte migration regulation of lipid catabolic process regulation of lipid metabolic process regulation of localization regulation of locomotion regulation of long-term synaptic depression regulation of long-term synaptic potentiation regulation of macromolecule metabolic process regulation of membrane potential regulation of metabolic process regulation of metal ion transport regulation of monoatomic ion transport regulation of mucus secretion regulation of multicellular organismal process regulation of muscle contraction regulation of muscle system process regulation of nervous system process regulation of neurotrophin production regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound transport regulation of nucleoside transport regulation of organic acid transport regulation of peptide secretion regulation of peptide transport regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of postsynaptic membrane potential regulation of potassium ion transport regulation of presynaptic cytosolic calcium ion concentration regulation of primary metabolic process regulation of programmed cell death regulation of protein dephosphorylation regulation of protein metabolic process regulation of protein modification process regulation of renal system process regulation of respiratory gaseous exchange by nervous system process regulation of respiratory gaseous exchange regulation of respiratory system process regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of secretion by cell regulation of secretion regulation of sensory perception of pain regulation of sensory perception regulation of signal transduction regulation of signaling regulation of striated muscle contraction regulation of synaptic plasticity regulation of synaptic transmission, GABAergic regulation of synaptic transmission, glutamatergic regulation of system process regulation of trans-synaptic signaling regulation of transport regulation of tube diameter regulation of tube size renal system process involved in regulation of blood volume renal system process involved in regulation of systemic arterial blood pressure renal system process response to abiotic stimulus response to chemical response to decreased oxygen levels response to external stimulus response to hypoxia response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to oxygen levels response to purine-containing compound response to stimulus response to stress response to temperature stimulus secretion by tissue secretion signal transduction signaling receptor activity signaling receptor binding signaling small molecule binding synapse synaptic membrane system development system process temperature homeostasis terminal bouton transmembrane signaling receptor activity transport triglyceride homeostasis vascular process in circulatory system vasodilation vesicle-mediated transport	GO:0001609 GO:0001659 GO:0001664 GO:0001666 GO:0001882 GO:0001883 GO:0001973 GO:0001977 GO:0002087 GO:0002376 GO:0002673 GO:0002674 GO:0002682 GO:0002683 GO:0002685 GO:0002686 GO:0002791 GO:0002793 GO:0003008 GO:0003013 GO:0003014 GO:0003018 GO:0003071 GO:0003084 GO:0003085 GO:0003093 GO:0003674 GO:0004888 GO:0004930 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0006605 GO:0006612 GO:0006629 GO:0006810 GO:0006873 GO:0006874 GO:0006897 GO:0006909 GO:0006937 GO:0006942 GO:0006950 GO:0006952 GO:0006954 GO:0007154 GO:0007165 GO:0007166 GO:0007186 GO:0007188 GO:0007193 GO:0007267 GO:0007399 GO:0007589 GO:0008016 GO:0008104 GO:0008150 GO:0008152 GO:0008217 GO:0008285 GO:0009056 GO:0009266 GO:0009581 GO:0009582 GO:0009605 GO:0009628 GO:0009892 GO:0009893 GO:0009894 GO:0009895 GO:0009896 GO:0009966 GO:0009967 GO:0009987 GO:0010033 GO:0010243 GO:0010562 GO:0010604 GO:0010646 GO:0010647 GO:0010648 GO:0010817 GO:0010959 GO:0014048 GO:0014050 GO:0014070 GO:0014074 GO:0016020 GO:0016042 GO:0016048 GO:0016192 GO:0016323 GO:0016477 GO:0019216 GO:0019220 GO:0019222 GO:0019725 GO:0023051 GO:0023052 GO:0023056 GO:0023057 GO:0030003 GO:0030054 GO:0030334 GO:0030336 GO:0030425 GO:0030673 GO:0031072 GO:0031253 GO:0031256 GO:0031323 GO:0031325 GO:0031347 GO:0031348 GO:0031399 GO:0031401 GO:0031644 GO:0031683 GO:0032101 GO:0032102 GO:0032228 GO:0032229 GO:0032239 GO:0032241 GO:0032242 GO:0032244 GO:0032279 GO:0032501 GO:0032502 GO:0032589 GO:0032795 GO:0032879 GO:0032890 GO:0032891 GO:0032899 GO:0032900 GO:0032941 GO:0032970 GO:0033036 GO:0035150 GO:0035296 GO:0035303 GO:0035304 GO:0035306 GO:0035307 GO:0035588 GO:0035590 GO:0036094 GO:0036293 GO:0038023 GO:0040012 GO:0040013 GO:0042127 GO:0042221 GO:0042311 GO:0042321 GO:0042323 GO:0042391 GO:0042592 GO:0042734 GO:0042749 GO:0042752 GO:0042754 GO:0042981 GO:0042995 GO:0043005 GO:0043025 GO:0043066 GO:0043067 GO:0043069 GO:0043195 GO:0043197 GO:0043266 GO:0043268 GO:0043269 GO:0043270 GO:0043408 GO:0043410 GO:0043576 GO:0043679 GO:0044057 GO:0044065 GO:0044238 GO:0044297 GO:0044305 GO:0044306 GO:0044309 GO:0044877 GO:0045184 GO:0045187 GO:0045188 GO:0045202 GO:0045211 GO:0045776 GO:0045777 GO:0045833 GO:0045834 GO:0045937 GO:0046883 GO:0046888 GO:0046903 GO:0046982 GO:0046983 GO:0048167 GO:0048518 GO:0048519 GO:0048521 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048731 GO:0048786 GO:0048856 GO:0048870 GO:0048871 GO:0048878 GO:0050727 GO:0050728 GO:0050789 GO:0050794 GO:0050795 GO:0050801 GO:0050804 GO:0050805 GO:0050806 GO:0050877 GO:0050878 GO:0050890 GO:0050896 GO:0050900 GO:0050906 GO:0050961 GO:0050965 GO:0050994 GO:0050995 GO:0050996 GO:0051046 GO:0051047 GO:0051048 GO:0051049 GO:0051050 GO:0051051 GO:0051171 GO:0051173 GO:0051174 GO:0051179 GO:0051234 GO:0051239 GO:0051241 GO:0051246 GO:0051247 GO:0051480 GO:0051606 GO:0051641 GO:0051668 GO:0051930 GO:0051931 GO:0051952 GO:0051953 GO:0051955 GO:0051956 GO:0051966 GO:0051967 GO:0055074 GO:0055080 GO:0055082 GO:0055088 GO:0055089 GO:0055090 GO:0055117 GO:0060078 GO:0060079 GO:0060089 GO:0060255 GO:0060292 GO:0062149 GO:0065007 GO:0065008 GO:0070050 GO:0070254 GO:0070255 GO:0070256 GO:0070328 GO:0070482 GO:0070727 GO:0071704 GO:0072657 GO:0080090 GO:0080134 GO:0086004 GO:0090066 GO:0090087 GO:0090150 GO:0090257 GO:0097060 GO:0097159 GO:0097190 GO:0097367 GO:0097746 GO:0098590 GO:0098657 GO:0098771 GO:0098793 GO:0098794 GO:0098801 GO:0098984 GO:0099177 GO:0099509 GO:0110165 GO:0120025 GO:1900271 GO:1900272 GO:1900452 GO:1900453 GO:1901363 GO:1901575 GO:1901698 GO:1902531 GO:1902533 GO:1903115 GO:1903522 GO:1903530 GO:1903531 GO:2000145 GO:2000146
135	adenosine A2a receptor	ADORA2A	Homo sapiens (human)	9606			G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor signaling pathway G protein-coupled glutamate receptor binding G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor activity G protein-coupled receptor binding G protein-coupled receptor signaling pathway actinin binding adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway alpha-actinin binding anatomical structure development anatomical structure morphogenesis anterograde trans-synaptic signaling apoptotic process apoptotic signaling pathway astrocyte activation asymmetric synapse axolemma behavior binding biological regulation biological_process blood circulation blood coagulation blood vessel diameter maintenance calmodulin binding cell activation cell body cell communication cell death cell junction cell projection membrane cell projection morphogenesis cell projection organization cell projection cell surface receptor signaling pathway cell-cell signaling cellular anatomical entity morphogenesis cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular defense response cellular process cellular_component central nervous system development chemical synaptic transmission circulatory system process coagulation cytoskeletal protein binding defense response dendrite developmental process eating behavior endocytosis enzyme binding establishment of localization excitatory postsynaptic potential feeding behavior glial cell activation glutamate receptor binding glutamatergic synapse hemostasis identical protein binding import into cell inflammatory response inhibitory postsynaptic potential intermediate filament leading edge membrane lipid binding localization locomotory behavior membrane depolarization membrane modulation of chemical synaptic transmission molecular transducer activity molecular_function multicellular organismal process negative regulation of T cell activation negative regulation of alpha-beta T cell activation negative regulation of apoptotic process negative regulation of biological process negative regulation of cell activation negative regulation of cell adhesion negative regulation of cell population proliferation negative regulation of cell-cell adhesion negative regulation of cellular process negative regulation of defense response negative regulation of immune system process negative regulation of inflammatory response negative regulation of leukocyte activation negative regulation of leukocyte cell-cell adhesion negative regulation of lymphocyte activation negative regulation of multicellular organismal process negative regulation of neuron apoptotic process negative regulation of programmed cell death negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of vascular permeability nervous system process neuron projection membrane neuron projection morphogenesis neuron projection neuron to neuron synapse neuronal cell body phagocytosis plasma membrane bounded cell projection morphogenesis plasma membrane bounded cell projection plasma membrane region plasma membrane polymeric cytoskeletal fiber positive regulation of acetylcholine secretion, neurotransmission positive regulation of amine transport positive regulation of amino acid transport positive regulation of apoptotic process positive regulation of apoptotic signaling pathway positive regulation of behavior positive regulation of biological process positive regulation of cell communication positive regulation of cellular process positive regulation of circadian rhythm positive regulation of circadian sleep/wake cycle, sleep positive regulation of establishment of protein localization positive regulation of glutamate secretion positive regulation of long-term synaptic potentiation positive regulation of multicellular organismal process positive regulation of neurotransmitter secretion positive regulation of neurotransmitter transport positive regulation of organic acid transport positive regulation of programmed cell death positive regulation of protein localization positive regulation of protein secretion positive regulation of protein transport positive regulation of response to stimulus positive regulation of secretion by cell positive regulation of secretion positive regulation of signal transduction positive regulation of signaling positive regulation of synaptic transmission, GABAergic positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, glutamatergic positive regulation of synaptic transmission positive regulation of transport positive regulation of urine volume postsynaptic membrane prepulse inhibition presynaptic active zone presynaptic membrane presynaptic modulation of chemical synaptic transmission programmed cell death protein binding protein kinase C-activating G protein-coupled receptor signaling pathway protein-containing complex binding purinergic nucleotide receptor signaling pathway regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of T cell activation regulation of acetylcholine secretion, neurotransmission regulation of alpha-beta T cell activation regulation of amine transport regulation of amino acid transport regulation of anatomical structure size regulation of apoptotic process regulation of apoptotic signaling pathway regulation of behavior regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of body fluid levels regulation of calcium ion transport regulation of catecholamine secretion regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular localization regulation of cellular metabolic process regulation of cellular process regulation of circadian rhythm regulation of circadian sleep/wake cycle, sleep regulation of circadian sleep/wake cycle regulation of defense response regulation of establishment of protein localization regulation of gene expression regulation of glutamate secretion regulation of immune system process regulation of inflammatory response regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of localization regulation of long-term synaptic potentiation regulation of lymphocyte activation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of membrane potential regulation of metabolic process regulation of metal ion transport regulation of mitochondrial membrane potential regulation of monoatomic ion transport regulation of multicellular organismal process regulation of neuron apoptotic process regulation of neurotransmitter secretion regulation of neurotransmitter transport regulation of nitrogen compound metabolic process regulation of norepinephrine secretion regulation of nucleobase-containing compound metabolic process regulation of organic acid transport regulation of postsynaptic membrane potential regulation of primary metabolic process regulation of programmed cell death regulation of protein localization regulation of protein secretion regulation of protein transport regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling regulation of synaptic plasticity regulation of synaptic transmission, GABAergic regulation of synaptic transmission, cholinergic regulation of synaptic transmission, glutamatergic regulation of trans-synaptic signaling regulation of transport regulation of tube diameter regulation of tube size regulation of urine volume regulation of vascular permeability renal system process response to alkaloid response to amine response to amphetamine response to caffeine response to chemical response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to purine-containing compound response to stimulus response to stress response to xenobiotic stimulus sensory perception signal transduction signaling receptor activity signaling receptor binding signaling supramolecular complex supramolecular fiber supramolecular polymer synapse synaptic membrane synaptic signaling synaptic transmission, cholinergic synaptic transmission, dopaminergic synaptic transmission, glutamatergic system development system process trans-synaptic signaling transmembrane signaling receptor activity transport type 5 metabotropic glutamate receptor binding vascular process in circulatory system vasodilation vesicle-mediated transport	GO:0001609 GO:0001664 GO:0001775 GO:0001956 GO:0001963 GO:0001973 GO:0001975 GO:0002682 GO:0002683 GO:0002694 GO:0002695 GO:0003008 GO:0003013 GO:0003014 GO:0003018 GO:0003674 GO:0004888 GO:0004930 GO:0005102 GO:0005488 GO:0005515 GO:0005516 GO:0005575 GO:0005882 GO:0005886 GO:0006355 GO:0006810 GO:0006897 GO:0006909 GO:0006915 GO:0006950 GO:0006952 GO:0006954 GO:0006968 GO:0007154 GO:0007162 GO:0007165 GO:0007166 GO:0007186 GO:0007188 GO:0007189 GO:0007205 GO:0007267 GO:0007268 GO:0007271 GO:0007417 GO:0007596 GO:0007599 GO:0007600 GO:0007610 GO:0007626 GO:0007631 GO:0008015 GO:0008092 GO:0008150 GO:0008219 GO:0008285 GO:0008289 GO:0009410 GO:0009653 GO:0009889 GO:0009966 GO:0009967 GO:0009987 GO:0010033 GO:0010243 GO:0010468 GO:0010556 GO:0010646 GO:0010647 GO:0010959 GO:0012501 GO:0014048 GO:0014049 GO:0014056 GO:0014057 GO:0014061 GO:0014070 GO:0014074 GO:0014075 GO:0016020 GO:0016043 GO:0016192 GO:0019219 GO:0019222 GO:0019899 GO:0022407 GO:0022408 GO:0023051 GO:0023052 GO:0023056 GO:0030030 GO:0030054 GO:0030155 GO:0030425 GO:0030673 GO:0031000 GO:0031253 GO:0031256 GO:0031323 GO:0031326 GO:0031347 GO:0031348 GO:0031802 GO:0032101 GO:0032102 GO:0032222 GO:0032224 GO:0032228 GO:0032230 GO:0032279 GO:0032501 GO:0032502 GO:0032589 GO:0032879 GO:0032880 GO:0032890 GO:0032892 GO:0032989 GO:0035150 GO:0035249 GO:0035254 GO:0035256 GO:0035296 GO:0035588 GO:0035590 GO:0035809 GO:0035810 GO:0038023 GO:0042127 GO:0042221 GO:0042311 GO:0042391 GO:0042734 GO:0042749 GO:0042752 GO:0042753 GO:0042755 GO:0042802 GO:0042805 GO:0042981 GO:0042995 GO:0043005 GO:0043025 GO:0043065 GO:0043066 GO:0043067 GO:0043068 GO:0043069 GO:0043114 GO:0043116 GO:0043269 GO:0043279 GO:0043523 GO:0043524 GO:0044297 GO:0044877 GO:0045187 GO:0045202 GO:0045211 GO:0045938 GO:0046634 GO:0046636 GO:0046928 GO:0048143 GO:0048167 GO:0048518 GO:0048519 GO:0048520 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048731 GO:0048786 GO:0048812 GO:0048856 GO:0048858 GO:0050433 GO:0050708 GO:0050714 GO:0050727 GO:0050728 GO:0050789 GO:0050794 GO:0050795 GO:0050804 GO:0050806 GO:0050817 GO:0050863 GO:0050865 GO:0050866 GO:0050868 GO:0050877 GO:0050878 GO:0050896 GO:0051046 GO:0051047 GO:0051049 GO:0051050 GO:0051171 GO:0051179 GO:0051222 GO:0051223 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051249 GO:0051250 GO:0051252 GO:0051393 GO:0051588 GO:0051590 GO:0051881 GO:0051899 GO:0051924 GO:0051952 GO:0051954 GO:0051955 GO:0051957 GO:0051966 GO:0051968 GO:0060078 GO:0060079 GO:0060080 GO:0060089 GO:0060134 GO:0060255 GO:0060341 GO:0061900 GO:0065007 GO:0065008 GO:0070201 GO:0071840 GO:0080090 GO:0080134 GO:0090066 GO:0097060 GO:0097190 GO:0097746 GO:0098590 GO:0098657 GO:0098916 GO:0098978 GO:0098984 GO:0099080 GO:0099081 GO:0099171 GO:0099177 GO:0099512 GO:0099513 GO:0099536 GO:0099537 GO:0110165 GO:0120025 GO:0120039 GO:1900271 GO:1900273 GO:1901698 GO:1903037 GO:1903038 GO:1903530 GO:1903532 GO:1903829 GO:1904951 GO:2001141 GO:2001233 GO:2001235
136	adenosine A2b receptor	ADORA2B	Homo sapiens (human)	9606			G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor signaling pathway G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor activity G protein-coupled receptor signaling pathway Schaffer collateral - CA1 synapse activation of adenylate cyclase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway binding biological regulation biological_process blood vessel diameter maintenance cGMP-mediated signaling cell junction cell surface receptor signaling pathway cellular anatomical entity cellular process cellular_component circulatory system process cyclic-nucleotide-mediated signaling establishment of localization in cell establishment of localization establishment of organelle localization exocytosis export from cell glutamatergic synapse immune effector process immune system process intracellular signal transduction leukocyte degranulation localization lysosome localization mast cell degranulation membrane modulation of chemical synaptic transmission molecular transducer activity molecular_function multicellular organismal process muscle system process negative regulation of biological process negative regulation of multicellular organismal process negative regulation of muscle contraction negative regulation of smooth muscle contraction organelle localization plasma membrane positive regulation of adenylate cyclase activity positive regulation of biological process positive regulation of biosynthetic process positive regulation of cGMP-mediated signaling positive regulation of catalytic activity positive regulation of cell communication positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of chemokine production positive regulation of chronic inflammatory response to non-antigenic stimulus positive regulation of chronic inflammatory response positive regulation of cyclase activity positive regulation of cytokine production positive regulation of defense response positive regulation of exocytosis positive regulation of gene expression positive regulation of immune effector process positive regulation of immune system process positive regulation of inflammatory response positive regulation of interleukin-6 production positive regulation of intracellular signal transduction positive regulation of leukocyte degranulation positive regulation of lyase activity positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of mast cell degranulation positive regulation of metabolic process positive regulation of molecular function positive regulation of multicellular organismal process positive regulation of regulated secretory pathway positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of secretion by cell positive regulation of secretion positive regulation of signal transduction positive regulation of signaling positive regulation of transport positive regulation of vascular endothelial growth factor production presynapse presynaptic modulation of chemical synaptic transmission protein binding purinergic nucleotide receptor signaling pathway regulated exocytosis regulation of adenylate cyclase activity regulation of anatomical structure size regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of cGMP-mediated signaling regulation of catalytic activity regulation of cell communication regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of chemokine production regulation of chronic inflammatory response to non-antigenic stimulus regulation of chronic inflammatory response regulation of cyclase activity regulation of cytokine production regulation of defense response regulation of exocytosis regulation of gene expression regulation of immune effector process regulation of immune system process regulation of inflammatory response regulation of interleukin-6 production regulation of intracellular signal transduction regulation of leukocyte degranulation regulation of leukocyte mediated immunity regulation of localization regulation of lyase activity regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of mast cell degranulation regulation of metabolic process regulation of molecular function regulation of multicellular organismal process regulation of muscle contraction regulation of muscle system process regulation of myeloid leukocyte mediated immunity regulation of regulated secretory pathway regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling regulation of smooth muscle contraction regulation of system process regulation of trans-synaptic signaling regulation of transport regulation of tube diameter regulation of tube size regulation of vascular endothelial growth factor production regulation of vesicle-mediated transport relaxation of muscle relaxation of smooth muscle relaxation of vascular associated smooth muscle second-messenger-mediated signaling secretion by cell secretion signal transduction signaling receptor activity synapse system process transmembrane signaling receptor activity transport vacuolar localization vascular process in circulatory system vasodilation vesicle-mediated transport	GO:0001609 GO:0001817 GO:0001819 GO:0001973 GO:0002252 GO:0002376 GO:0002676 GO:0002678 GO:0002682 GO:0002684 GO:0002697 GO:0002699 GO:0002703 GO:0002880 GO:0002882 GO:0002886 GO:0003008 GO:0003012 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0004930 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0006810 GO:0006887 GO:0006937 GO:0006940 GO:0007165 GO:0007166 GO:0007186 GO:0007188 GO:0007189 GO:0007190 GO:0008150 GO:0009889 GO:0009891 GO:0009893 GO:0009966 GO:0009967 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010574 GO:0010575 GO:0010604 GO:0010628 GO:0010646 GO:0010647 GO:0010752 GO:0010753 GO:0016020 GO:0016192 GO:0017157 GO:0019222 GO:0019932 GO:0019934 GO:0019935 GO:0023051 GO:0023056 GO:0030054 GO:0031279 GO:0031281 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031347 GO:0031349 GO:0032101 GO:0032103 GO:0032418 GO:0032501 GO:0032642 GO:0032675 GO:0032722 GO:0032755 GO:0032879 GO:0032940 GO:0035150 GO:0035296 GO:0035556 GO:0035588 GO:0035590 GO:0038023 GO:0042311 GO:0043085 GO:0043299 GO:0043300 GO:0043302 GO:0043303 GO:0043304 GO:0043306 GO:0044057 GO:0044093 GO:0044557 GO:0045055 GO:0045202 GO:0045761 GO:0045762 GO:0045921 GO:0045932 GO:0045986 GO:0046903 GO:0048518 GO:0048519 GO:0048522 GO:0048583 GO:0048584 GO:0050727 GO:0050729 GO:0050789 GO:0050790 GO:0050794 GO:0050804 GO:0051046 GO:0051047 GO:0051049 GO:0051050 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051339 GO:0051349 GO:0051640 GO:0051649 GO:0051656 GO:0060087 GO:0060089 GO:0060255 GO:0060627 GO:0065007 GO:0065008 GO:0065009 GO:0080134 GO:0090066 GO:0090075 GO:0090257 GO:0097746 GO:0098685 GO:0098793 GO:0098978 GO:0099171 GO:0099177 GO:0110165 GO:0140352 GO:1902531 GO:1902533 GO:1903305 GO:1903307 GO:1903530 GO:1903532 GO:1990849
140	adenosine A3 receptor	ADORA3	Homo sapiens (human)	9606			G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor signaling pathway G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor activity G protein-coupled receptor signaling pathway Schaffer collateral - CA1 synapse activation of adenylate cyclase activity biological regulation biological_process cell junction cell projection cell surface receptor signaling pathway cellular anatomical entity cellular process cellular_component defense response dendrite inflammatory response membrane modulation of chemical synaptic transmission molecular transducer activity molecular_function negative regulation of DNA-binding transcription factor activity negative regulation of NF-kappaB transcription factor activity negative regulation of biological process negative regulation of cell migration negative regulation of cell motility negative regulation of cell population proliferation negative regulation of cellular process negative regulation of locomotion negative regulation of molecular function neuron projection plasma membrane bounded cell projection plasma membrane region plasma membrane positive regulation of adenylate cyclase activity positive regulation of catalytic activity positive regulation of cyclase activity positive regulation of lyase activity positive regulation of molecular function presynaptic membrane presynaptic modulation of chemical synaptic transmission purinergic nucleotide receptor signaling pathway regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of adenylate cyclase activity regulation of amine transport regulation of biological process regulation of biosynthetic process regulation of blood circulation regulation of catalytic activity regulation of catecholamine secretion regulation of cell communication regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cyclase activity regulation of gene expression regulation of heart contraction regulation of localization regulation of locomotion regulation of lyase activity regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of norepinephrine secretion regulation of nucleobase-containing compound metabolic process regulation of primary metabolic process regulation of secretion by cell regulation of secretion regulation of signaling regulation of system process regulation of trans-synaptic signaling regulation of transport response to stimulus response to stress response to wounding signal transduction signaling receptor activity synapse synaptic membrane transmembrane signaling receptor activity	GO:0001609 GO:0001973 GO:0003674 GO:0004888 GO:0004930 GO:0005575 GO:0005886 GO:0006355 GO:0006950 GO:0006952 GO:0006954 GO:0007165 GO:0007166 GO:0007186 GO:0007190 GO:0008016 GO:0008150 GO:0008285 GO:0009611 GO:0009889 GO:0009987 GO:0010468 GO:0010556 GO:0010646 GO:0014061 GO:0016020 GO:0019219 GO:0019222 GO:0023051 GO:0030054 GO:0030334 GO:0030336 GO:0030425 GO:0031279 GO:0031281 GO:0031323 GO:0031326 GO:0032088 GO:0032879 GO:0035588 GO:0035590 GO:0038023 GO:0040012 GO:0040013 GO:0042127 GO:0042734 GO:0042995 GO:0043005 GO:0043085 GO:0043433 GO:0044057 GO:0044092 GO:0044093 GO:0045202 GO:0045761 GO:0045762 GO:0048519 GO:0048523 GO:0050433 GO:0050789 GO:0050790 GO:0050794 GO:0050804 GO:0050896 GO:0051046 GO:0051049 GO:0051090 GO:0051171 GO:0051239 GO:0051252 GO:0051339 GO:0051349 GO:0051952 GO:0060089 GO:0060255 GO:0065007 GO:0065009 GO:0080090 GO:0097060 GO:0098590 GO:0098685 GO:0099171 GO:0099177 GO:0110165 GO:0120025 GO:1903522 GO:1903530 GO:2000145 GO:2000146 GO:2001141
141	ADP-ribosylarginine hydrolase	ADPRH Aliases: ARH1 [Protein ADP-ribosylarginine] hydrolase	Homo sapiens (human)	9606	autosomal recessive hypercholesterolemia cancer cardiomyopathy cholera endomyocardial fibrosis familial hypercholesterolemia hypertrophic cardiomyopathy ovarian cancer ovarian carcinoma	DOID:0050700 DOID:0090105 DOID:11984 DOID:12932 DOID:13810 DOID:1498 DOID:162 DOID:2394 DOID:4001	ADP-ribosylarginine hydrolase activity alkali metal ion binding binding biological_process catalytic activity, acting on a protein catalytic activity cation binding cellular anatomical entity cellular_component extracellular space hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds hydrolase activity ion binding macromolecule metabolic process macromolecule modification magnesium ion binding metabolic process metal ion binding molecular_function nitrogen compound metabolic process organic substance metabolic process organonitrogen compound metabolic process potassium ion binding primary metabolic process protein binding protein de-ADP-ribosylation protein metabolic process protein modification process	GO:0000287 GO:0003674 GO:0003824 GO:0003875 GO:0005488 GO:0005515 GO:0005575 GO:0005615 GO:0006807 GO:0008150 GO:0008152 GO:0016787 GO:0016798 GO:0016799 GO:0019538 GO:0030955 GO:0031420 GO:0036211 GO:0043167 GO:0043169 GO:0043170 GO:0043412 GO:0044238 GO:0046872 GO:0051725 GO:0071704 GO:0110165 GO:0140096 GO:1901564
142	poly(ADP-ribose) polymerase 1	PARP1 Aliases: ARTD1 PARP PARS Poly-PARP	Homo sapiens (human)	9606	Alzheimer's disease 10 Alzheimer's disease 11 Alzheimer's disease 12 Alzheimer's disease 13 Alzheimer's disease 14 Alzheimer's disease 15 Alzheimer's disease 1 Alzheimer's disease 2 Alzheimer's disease 3 Alzheimer's disease 5 Alzheimer's disease 6 Alzheimer's disease 7 Alzheimer's disease 8 Alzheimer's disease B-cell lymphoma Balo concentric sclerosis Barrett's esophagus Burkitt lymphoma Chagas disease Cockayne syndrome Cornelia de Lange syndrome Crohn's colitis Crohn's disease Down syndrome Dubowitz syndrome Duchenne muscular dystrophy Ewing sarcoma Fanconi anemia complementation group A Fanconi anemia Gilles de la Tourette syndrome Graves' disease Hailey-Hailey disease Henoch-Schoenlein purpura Huntington's disease-like 1 Huntington's disease-like 2 Huntington's disease IgA glomerulonephritis Keshan disease Langerhans-cell histiocytosis Lynch syndrome MHC class II deficiency Marinesco-Sjogren syndrome Meniere's disease Nijmegen breakage syndrome Noonan syndrome 10 Noonan syndrome 1 Noonan syndrome 2 Noonan syndrome 3 Noonan syndrome 4 Noonan syndrome 5 Noonan syndrome 6 Noonan syndrome 7 Noonan syndrome 8 Noonan syndrome 9 Noonan syndrome Parkinson's disease 19A Parkinson's disease 23 Parkinson's disease 2 Parkinson's disease 4 Parkinson's disease Patau syndrome Peyronie's disease Pick's disease Prader-Willi syndrome Reye syndrome Richter's syndrome Robinow syndrome Rothmund-Thomson syndrome Seckel syndrome Sertoli cell-only syndrome Sezary's disease Silver-Russell syndrome Stevens-Johnson syndrome T-cell acute lymphoblastic leukemia Treacher Collins syndrome Warsaw breakage syndrome Weissenbacher-Zweymuller syndrome Werner syndrome X-linked Aarskog syndrome X-linked ichthyosis Y-linked spermatogenic failure 1 Zika fever abdominal aortic aneurysm abdominal obesity-metabolic syndrome 1 acquired immunodeficiency syndrome acrodermatitis acute biphenotypic leukemia acute leukemia acute myeloid leukemia acute myocardial infarction adenocarcinoma adenoma adenosarcoma adenosine deaminase deficiency adrenal gland cancer adrenoleukodystrophy adult fibrosarcoma adult medulloblastoma age related macular degeneration agranulocytosis alexia allergic asthma allergic rhinitis alopecia alternating hemiplegia of childhood amnestic disorder amyloidosis amyotrophic lateral sclerosis anaplastic astrocytoma androgen insensitivity syndrome androgenic alopecia anemia anthrax disease anxiety disorder arachnoiditis arteriolosclerosis arteriosclerosis arteriosclerotic cardiovascular disease arthritis arthropathy asthma ataxia with oculomotor apraxia type 1 atelosteogenesis atherosclerosis atrial fibrillation autoimmune disease autoimmune lymphoproliferative syndrome autonomic neuropathy autosomal dominant Emery-Dreifuss muscular dystrophy 2 autosomal dominant Robinow syndrome 1 autosomal dominant Robinow syndrome 2 autosomal dominant Robinow syndrome 3 autosomal dominant cutis laxa 1 autosomal dominant cutis laxa 2 autosomal dominant cutis laxa 3 autosomal dominant cutis laxa autosomal dominant limb-girdle muscular dystrophy type 1 autosomal dominant limb-girdle muscular dystrophy type 1H autosomal dominant limb-girdle muscular dystrophy type 2 autosomal dominant limb-girdle muscular dystrophy type 3 autosomal dominant limb-girdle muscular dystrophy autosomal recessive Robinow syndrome autosomal recessive cutis laxa type IA autosomal recessive cutis laxa type IB autosomal recessive cutis laxa type II classic type autosomal recessive cutis laxa type IIA autosomal recessive cutis laxa type IIB autosomal recessive cutis laxa type IIC autosomal recessive cutis laxa type IID autosomal recessive cutis laxa type IIIA autosomal recessive cutis laxa type IIIB autosomal recessive limb-girdle muscular dystrophy type 2A autosomal recessive limb-girdle muscular dystrophy type 2B autosomal recessive limb-girdle muscular dystrophy type 2C autosomal recessive limb-girdle muscular dystrophy type 2D autosomal recessive limb-girdle muscular dystrophy type 2E autosomal recessive limb-girdle muscular dystrophy type 2F autosomal recessive limb-girdle muscular dystrophy type 2G autosomal recessive limb-girdle muscular dystrophy type 2H autosomal recessive limb-girdle muscular dystrophy type 2I autosomal recessive limb-girdle muscular dystrophy type 2J autosomal recessive limb-girdle muscular dystrophy type 2K autosomal recessive limb-girdle muscular dystrophy type 2L autosomal recessive limb-girdle muscular dystrophy type 2M autosomal recessive limb-girdle muscular dystrophy type 2N autosomal recessive limb-girdle muscular dystrophy type 2O autosomal recessive limb-girdle muscular dystrophy type 2P autosomal recessive limb-girdle muscular dystrophy type 2Q autosomal recessive limb-girdle muscular dystrophy type 2S autosomal recessive limb-girdle muscular dystrophy type 2T autosomal recessive limb-girdle muscular dystrophy type 2U autosomal recessive limb-girdle muscular dystrophy type 2Y autosomal recessive limb-girdle muscular dystrophy bacterial meningitis bacterial sepsis balanitis xerotica obliterans benign mesothelioma bile duct adenocarcinoma bile duct carcinoma bladder carcinoma bladder urothelial carcinoma bone marrow cancer bone osteosarcoma borna disease botryoid rhabdomyosarcoma brachydactyly type B1 brachydactyly brain cancer brain ischemia brain stem infarction breast adenocarcinoma breast cancer breast carcinoma bronchus cancer bronchus carcinoma cancer carcinoma cardiomyopathy cardiovascular system disease celiac disease central nervous system cancer central nervous system disease central nervous system lymphoma cerebellar ataxia cerebellar disease cerebral artery occlusion cerebral degeneration cerebral infarction cerebrovascular disease cervical adenocarcinoma cervical cancer cervix carcinoma cervix uteri carcinoma in situ childhood acute lymphocytic leukemia childhood astrocytic tumor childhood cerebral astrocytoma childhood germ cell cancer childhood leukemia childhood medulloblastoma childhood osteosarcoma childhood pilocytic astrocytoma cholangiocarcinoma chondrodysplasia-pseudohermaphroditism syndrome chondrosarcoma chordoma chromophobe renal cell carcinoma chronic fatigue syndrome chronic interstitial cystitis chronic kidney disease chronic lymphocytic leukemia chronic monocytic leukemia chronic myeloid leukemia chronic myelomonocytic leukemia chronic obstructive pulmonary disease clear cell renal cell carcinoma colitis collecting duct carcinoma colon cancer colon carcinoma colonic benign neoplasm colorectal cancer colorectal carcinoma common wart congenital muscular dystrophy congestive heart failure corneal disease coronary artery disease coronary thrombosis cribriform carcinoma cutaneous fibrous histiocytoma cutis laxa deafness-dystonia-optic neuronopathy syndrome dedifferentiated liposarcoma degeneration of macula and posterior pole denture stomatitis depressive disorder dermatitis diabetes mellitus diabetic autonomic neuropathy diabetic cataract diabetic ketoacidosis diabetic neuropathy diabetic polyneuropathy diabetic retinopathy differentiated thyroid gland carcinoma diffuse large B-cell lymphoma disease of metabolism dissociative amnesia distal arthrogryposis distal myopathy duodenum cancer dyslexia dysplastic nevus syndrome dysthymic disorder embryoma embryonal cancer embryonal rhabdomyosarcoma encephalitis encephalomyelitis endocrine exophthalmos endolymphatic hydrops endometrial adenocarcinoma endometrial cancer endometrial carcinoma endometriosis of uterus endometriosis endomyocardial fibrosis epilepsy epithelioid leiomyosarcoma epithelioid malignant peripheral nerve sheath tumor epithelioid sarcoma esophageal cancer esophageal carcinoma esophagus adenocarcinoma esophagus small cell carcinoma esophagus squamous cell carcinoma essential hypertension essential thrombocythemia eye disease facioscapulohumeral muscular dystrophy familial adenomatous polyposis 1 familial adenomatous polyposis familiar ovarian carcinoma fibrillary astrocytoma fibrosarcoma follicular adenoma frozen shoulder gastroenteritis gastrointestinal system disease gemistocytic astrocytoma generalized anxiety disorder germ cell and embryonal cancer germ cell cancer germinoma giant cell glioblastoma glioblastoma gliosarcoma glomerulonephritis glycogen storage disease II goiter granular cell carcinoma granular corneal dystrophy 2 head and neck cancer head and neck squamous cell carcinoma heart cancer heart disease hematologic cancer hepatitis A hepatitis B hepatitis hepatoblastoma hepatocellular carcinoma hereditary breast ovarian cancer syndrome hidradenoma high grade glioma human immunodeficiency virus infectious disease hypereosinophilic syndrome hyperglycemia hypersensitivity vasculitis hypertension hyperthyroidism hypertrophic cardiomyopathy hypoparathyroidism-deafness-renal disease syndrome idiopathic interstitial pneumonia idiopathic pulmonary fibrosis ileitis ileocolitis immune system disease inflammatory bowel disease 1 inflammatory bowel disease inflammatory breast carcinoma intellectual disability intermediate coronary syndrome interstitial cystitis intestinal disease intracranial aneurysm intrahepatic cholangiocarcinoma intrinsic asthma islet cell tumor juvenile myelomonocytic leukemia juvenile pilocytic astrocytoma keratoconus kidney disease kidney failure large cell medulloblastoma large intestine cancer laryngeal squamous cell carcinoma learning disability leiomyoma leiomyosarcoma leukemia leukopenia limb-girdle muscular dystrophy liposarcoma liver cancer liver carcinoma liver cirrhosis luminal breast carcinoma A lung adenocarcinoma lung benign neoplasm lung cancer lung carcinoma lung non-small cell carcinoma lung small cell carcinoma lung squamous cell carcinoma lupus erythematosus lymphangioleiomyomatosis lymphoma macrocytic anemia macular degeneration major depressive disorder mal de Meleda malignant astrocytoma malignant mesothelioma malignant peripheral nerve sheath tumor malignant pleural mesothelioma mantle cell lymphoma medulloblastoma medullomyoblastoma melancholic depression melanoma melanotic medulloblastoma meningitis microcephalic osteodysplastic primordial dwarfism type I microcephalic osteodysplastic primordial dwarfism type II microcystic adenoma microphthalmia middle cerebral artery infarction mitochondrial DNA depletion syndrome mixed glioma monoclonal gammopathy of uncertain significance multiple myeloma multiple sclerosis muscular dystrophy myelitis myelodysplastic syndrome myeloproliferative neoplasm myocardial infarction myofibrillar myopathy 1 myofibrillar myopathy 3 myxoid leiomyosarcoma narcolepsy nasopharynx carcinoma nephritis nephroblastoma nephrosis nervous system disease neurilemmoma neuroblastoma neurodegenerative disease neuroendocrine carcinoma neuroendocrine tumor neurofibrosarcoma neuronal ceroid lipofuscinosis 1 neurotic disorder neutropenia nodular nonsuppurative panniculitis non-Hodgkin lymphoma nonpapillary renal cell carcinoma obesity obsolete Matthew-Wood syndrome obsolete autosomal dominant limb-girdle muscular dystrophy type 1A obsolete autosomal dominant limb-girdle muscular dystrophy type 1B obsolete autosomal dominant limb-girdle muscular dystrophy type 1C obsolete autosomal recessive limb-girdle muscular dystrophy type 2R obsolete melancholia obsolete precursor B lymphoblastic lymphoma/leukemia obsolete type 1 diabetes mellitus 9 obsolete ymphosarcoma oculopharyngeal muscular dystrophy oligospermia osteoarthritis osteosarcoma ovarian cancer ovarian carcinoma pancreatic cancer pancreatic carcinoma pancreatic ductal adenocarcinoma panniculitis papillary adenocarcinoma papillary adenoma papillary renal cell carcinoma paraganglioma parapsoriasis patent ductus arteriosus perinatal necrotizing enterocolitis peritoneal carcinoma pheochromocytoma phobic disorder phototoxic dermatitis pilocytic astrocytoma pleomorphic liposarcoma pneumonia premature menopause primary cerebellar degeneration primary cutaneous amyloidosis primary immunodeficiency disease primary open angle glaucoma primary pulmonary hypertension proctitis progeria progressive multifocal leukoencephalopathy progressive muscular atrophy prostate cancer prostate carcinoma protoplasmic astrocytoma prune belly syndrome psoriasis pulmonary emphysema pustulosis of palm and sole pyoureter rectal benign neoplasm rectum adenocarcinoma rectum cancer renal carcinoma renal cell carcinoma respiratory failure restrictive dermopathy reticulosarcoma retinal disease retinitis retrograde amnesia rhabdomyosarcoma rheumatic fever rheumatoid arthritis rippling muscle disease 2 sarcoma sarcomatoid carcinoma sarcomatoid renal cell carcinoma schizophrenia scleroderma secondary Parkinson disease senile cataract severe combined immunodeficiency severe congenital neutropenia silent myocardial infarction skin benign neoplasm skin cancer skin melanoma skin papilloma skin tag small intestine cancer spindle cell sarcoma sporadic breast cancer squamous cell carcinoma status epilepticus steatotic liver disease stomach cancer stomach carcinoma stomatitis subependymal giant cell astrocytoma syringoma systemic lupus erythematosus systemic scleroderma teratocarcinoma thymic carcinoma thymoma thyroid adenoma thyroid cancer thyroid gland carcinoma thyroid gland disease thyroid gland papillary carcinoma thyrotoxicosis tongue squamous cell carcinoma transient cerebral ischemia trigeminal neuralgia trypanosomiasis tubular adenocarcinoma type 1 diabetes mellitus 10 type 1 diabetes mellitus 11 type 1 diabetes mellitus 12 type 1 diabetes mellitus 13 type 1 diabetes mellitus 15 type 1 diabetes mellitus 17 type 1 diabetes mellitus 18 type 1 diabetes mellitus 19 type 1 diabetes mellitus 20 type 1 diabetes mellitus 21 type 1 diabetes mellitus 22 type 1 diabetes mellitus 23 type 1 diabetes mellitus 24 type 1 diabetes mellitus 2 type 1 diabetes mellitus 3 type 1 diabetes mellitus 4 type 1 diabetes mellitus 5 type 1 diabetes mellitus 6 type 1 diabetes mellitus 7 type 1 diabetes mellitus 8 type 1 diabetes mellitus type 2 diabetes mellitus ulcerative colitis ulcerative stomatitis uremia ureteral obstruction urinary bladder cancer uterine corpus cancer uterine fibroid uveal melanoma vasomotor rhinitis vertebrobasilar insufficiency viral infectious disease viral meningitis vitiligo xeroderma pigmentosum group A	DOID:0014667 DOID:0040085 DOID:0050083 DOID:0050156 DOID:0050387 DOID:0050424 DOID:0050426 DOID:0050429 DOID:0050457 DOID:0050458 DOID:0050557 DOID:0050569 DOID:0050581 DOID:0050589 DOID:0050590 DOID:0050635 DOID:0050639 DOID:0050646 DOID:0050648 DOID:0050700 DOID:0050745 DOID:0050746 DOID:0050753 DOID:0050754 DOID:0050757 DOID:0050771 DOID:0050773 DOID:0050801 DOID:0050819 DOID:0050865 DOID:0050902 DOID:0050908 DOID:0060058 DOID:0060060 DOID:0060180 DOID:0060189 DOID:0060190 DOID:0060192 DOID:0060215 DOID:0060224 DOID:0060254 DOID:0060255 DOID:0060368 DOID:0060444 DOID:0060478 DOID:0060535 DOID:0060548 DOID:0060578 DOID:0060580 DOID:0060581 DOID:0060582 DOID:0060583 DOID:0060584 DOID:0060585 DOID:0060586 DOID:0060587 DOID:0060588 DOID:0060608 DOID:0060609 DOID:0060644 DOID:0060762 DOID:0060764 DOID:0060765 DOID:0060766 DOID:0060767 DOID:0060862 DOID:0060878 DOID:0060889 DOID:0060891 DOID:0060895 DOID:0060896 DOID:0070129 DOID:0070130 DOID:0070131 DOID:0070132 DOID:0070133 DOID:0070134 DOID:0070135 DOID:0070136 DOID:0070137 DOID:0070138 DOID:0070140 DOID:0070141 DOID:0070142 DOID:0070186 DOID:0070247 DOID:0070329 DOID:0080092 DOID:0080094 DOID:0080144 DOID:0080188 DOID:0080195 DOID:0080199 DOID:0080348 DOID:0080409 DOID:0080525 DOID:0080531 DOID:0090103 DOID:0090104 DOID:0110035 DOID:0110037 DOID:0110038 DOID:0110039 DOID:0110041 DOID:0110042 DOID:0110043 DOID:0110044 DOID:0110045 DOID:0110046 DOID:0110047 DOID:0110048 DOID:0110273 DOID:0110274 DOID:0110275 DOID:0110276 DOID:0110277 DOID:0110278 DOID:0110279 DOID:0110280 DOID:0110281 DOID:0110282 DOID:0110283 DOID:0110284 DOID:0110285 DOID:0110286 DOID:0110287 DOID:0110289 DOID:0110292 DOID:0110293 DOID:0110294 DOID:0110295 DOID:0110296 DOID:0110297 DOID:0110298 DOID:0110299 DOID:0110300 DOID:0110301 DOID:0110302 DOID:0110303 DOID:0110304 DOID:0110305 DOID:0110306 DOID:0110721 DOID:0110741 DOID:0110742 DOID:0110743 DOID:0110744 DOID:0110745 DOID:0110746 DOID:0110747 DOID:0110748 DOID:0110749 DOID:0110750 DOID:0110751 DOID:0110752 DOID:0110753 DOID:0110754 DOID:0110755 DOID:0110756 DOID:0110757 DOID:0110758 DOID:0110759 DOID:0110760 DOID:0110761 DOID:0110843 DOID:0110892 DOID:0110969 DOID:0111095 DOID:10021 DOID:10041 DOID:10113 DOID:10124 DOID:10126 DOID:10127 DOID:10154 DOID:10283 DOID:10286 DOID:10310 DOID:1040 DOID:10534 DOID:10588 DOID:1059 DOID:10608 DOID:10629 DOID:10652 DOID:1070 DOID:1074 DOID:10763 DOID:10787 DOID:10825 DOID:10871 DOID:10914 DOID:10941 DOID:10952 DOID:11037 DOID:11054 DOID:1107 DOID:11119 DOID:11123 DOID:1115 DOID:11162 DOID:11165 DOID:114 DOID:11503 DOID:11504 DOID:11665 DOID:117 DOID:11719 DOID:11720 DOID:11723 DOID:11724 DOID:11725 DOID:11727 DOID:11847 DOID:11870 DOID:11875 DOID:11934 DOID:11983 DOID:11984 DOID:12098 DOID:12139 DOID:12140 DOID:12156 DOID:12176 DOID:1227 DOID:12306 DOID:12359 DOID:12361 DOID:1240 DOID:12549 DOID:12603 DOID:127 DOID:12785 DOID:12858 DOID:1287 DOID:1289 DOID:12932 DOID:12987 DOID:13003 DOID:1319 DOID:13223 DOID:1324 DOID:1325 DOID:13328 DOID:13417 DOID:13477 DOID:13548 DOID:13636 DOID:1380 DOID:13832 DOID:13949 DOID:14188 DOID:14221 DOID:14228 DOID:1425 DOID:14250 DOID:14320 DOID:14330 DOID:1443 DOID:14525 DOID:14557 DOID:14681 DOID:1470 DOID:14796 DOID:1520 DOID:1525 DOID:1526 DOID:1586 DOID:1595 DOID:1596 DOID:1612 DOID:162 DOID:1678 DOID:169 DOID:1700 DOID:1703 DOID:1749 DOID:1781 DOID:1790 DOID:1791 DOID:1793 DOID:1799 DOID:1800 DOID:1824 DOID:1826 DOID:1837 DOID:1909 DOID:1936 DOID:1967 DOID:1974 DOID:1984 DOID:1993 DOID:1996 DOID:2007 DOID:2030 DOID:2043 DOID:2065 DOID:2154 DOID:219 DOID:2224 DOID:2226 DOID:2237 DOID:224 DOID:2316 DOID:2326 DOID:2348 DOID:2349 DOID:235 DOID:2355 DOID:2361 DOID:2377 DOID:2394 DOID:2527 DOID:2531 DOID:2571 DOID:2645 DOID:2722 DOID:2723 DOID:2732 DOID:2752 DOID:2786 DOID:2797 DOID:2841 DOID:2848 DOID:2870 DOID:2871 DOID:2876 DOID:288 DOID:289 DOID:2891 DOID:2893 DOID:2908 DOID:2914 DOID:2921 DOID:2962 DOID:2986 DOID:299 DOID:2994 DOID:305 DOID:3068 DOID:3069 DOID:3070 DOID:3071 DOID:3074 DOID:3078 DOID:3079 DOID:3083 DOID:3095 DOID:3112 DOID:3127 DOID:3144 DOID:3165 DOID:3172 DOID:3178 DOID:318 DOID:3192 DOID:322 DOID:3234 DOID:3246 DOID:3247 DOID:3255 DOID:3275 DOID:3284 DOID:3302 DOID:3304 DOID:3305 DOID:331 DOID:3319 DOID:332 DOID:3347 DOID:3355 DOID:3361 DOID:3369 DOID:3371 DOID:3376 DOID:3382 DOID:3393 DOID:3458 DOID:3459 DOID:3490 DOID:3498 DOID:3512 DOID:3516 DOID:3523 DOID:3525 DOID:3526 DOID:3571 DOID:3612 DOID:3620 DOID:3683 DOID:3702 DOID:3748 DOID:381 DOID:3857 DOID:3861 DOID:3864 DOID:3868 DOID:3869 DOID:3883 DOID:3896 DOID:3904 DOID:3905 DOID:3907 DOID:3908 DOID:3910 DOID:3911 DOID:3953 DOID:3963 DOID:3969 DOID:4001 DOID:4006 DOID:4007 DOID:4015 DOID:4159 DOID:417 DOID:418 DOID:419 DOID:4195 DOID:4235 DOID:4258 DOID:4362 DOID:4398 DOID:4407 DOID:4418 DOID:4428 DOID:4448 DOID:4450 DOID:4451 DOID:4464 DOID:4465 DOID:4467 DOID:4471 DOID:4473 DOID:4481 DOID:4543 DOID:4674 DOID:4676 DOID:4730 DOID:4766 DOID:4851 DOID:4896 DOID:4897 DOID:4903 DOID:4905 DOID:4914 DOID:4928 DOID:4929 DOID:4947 DOID:4960 DOID:4964 DOID:50 DOID:5041 DOID:5076 DOID:5077 DOID:5082 DOID:5154 DOID:5162 DOID:5199 DOID:526 DOID:5264 DOID:5268 DOID:5295 DOID:5403 DOID:5409 DOID:5419 DOID:5517 DOID:552 DOID:5520 DOID:557 DOID:5603 DOID:5614 DOID:5672 DOID:5675 DOID:5679 DOID:5683 DOID:5688 DOID:5702 DOID:5810 DOID:5812 DOID:5844 DOID:5854 DOID:591 DOID:5940 DOID:6000 DOID:6039 DOID:6053 DOID:612 DOID:615 DOID:6193 DOID:6204 DOID:6263 DOID:627 DOID:635 DOID:640 DOID:643 DOID:657 DOID:6683 DOID:6688 DOID:6713 DOID:6726 DOID:6811 DOID:6812 DOID:684 DOID:686 DOID:687 DOID:6873 DOID:688 DOID:6901 DOID:7005 DOID:7007 DOID:7008 DOID:7061 DOID:707 DOID:7134 DOID:7148 DOID:7400 DOID:7427 DOID:7442 DOID:7474 DOID:769 DOID:7693 DOID:77 DOID:7757 DOID:784 DOID:7997 DOID:7998 DOID:8029 DOID:8353 DOID:8398 DOID:848 DOID:8538 DOID:8541 DOID:8544 DOID:8552 DOID:8577 DOID:8584 DOID:8593 DOID:8616 DOID:863 DOID:8675 DOID:8677 DOID:8778 DOID:8805 DOID:8857 DOID:8893 DOID:8923 DOID:8927 DOID:8947 DOID:8986 DOID:8991 DOID:9074 DOID:9088 DOID:9119 DOID:9120 DOID:9206 DOID:9256 DOID:9261 DOID:9277 DOID:934 DOID:9351 DOID:9352 DOID:9360 DOID:9408 DOID:9415 DOID:9452 DOID:9460 DOID:9470 DOID:9471 DOID:9538 DOID:9588 DOID:9637 DOID:9669 DOID:9673 DOID:9675 DOID:9743 DOID:9744 DOID:9809 DOID:9848 DOID:9849 DOID:987 DOID:9884 DOID:9953 DOID:9970 DOID:999	ATP generation from poly-ADP-D-ribose ATP metabolic process DNA ADP-ribosylation DNA binding DNA damage response DNA metabolic process DNA modification DNA repair DNA-binding transcription factor binding DNA-templated DNA replication maintenance of fidelity DNA-templated transcription NAD DNA ADP-ribosyltransferase activity NAD binding NAD+ ADP-ribosyltransferase activity NAD+- protein-aspartate ADP-ribosyltransferase activity NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity NAD+-histone H2BS6 serine ADP-ribosyltransferase activity NAD+-histone H3S10 serine ADP-ribosyltransferase activity NAD+-protein ADP-ribosyltransferase activity NAD+-protein-glutamate ADP-ribosyltransferase activity NAD+-protein-histidine ADP-ribosyltransferase activity NAD+-protein-serine ADP-ribosyltransferase activity NAD+-protein-tyrosine ADP-ribosyltransferase activity R-SMAD binding RNA binding RNA biosynthetic process RNA metabolic process RNA polymerase II-specific DNA-binding transcription factor binding SMAD binding adenyl nucleotide binding anatomical structure development apoptotic process aromatic compound biosynthetic process binding biological process involved in interspecies interaction between organisms biological regulation biological_process biosynthetic process carbohydrate biosynthetic process carbohydrate derivative metabolic process carbohydrate metabolic process catalytic activity, acting on a protein catalytic activity cation binding cell death cell differentiation cell surface receptor signaling pathway cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular component organization or biogenesis cellular component organization cellular developmental process cellular localization cellular macromolecule localization cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular response to UV cellular response to abiotic stimulus cellular response to amyloid-beta cellular response to chemical stimulus cellular response to chemical stress cellular response to endogenous stimulus cellular response to environmental stimulus cellular response to growth factor stimulus cellular response to hormone stimulus cellular response to inorganic substance cellular response to insulin stimulus cellular response to light stimulus cellular response to metal ion cellular response to nerve growth factor stimulus cellular response to nitrogen compound cellular response to organic substance cellular response to organonitrogen compound cellular response to oxidative stress cellular response to oxygen-containing compound cellular response to peptide hormone stimulus cellular response to peptide cellular response to radiation cellular response to stimulus cellular response to stress cellular response to zinc ion cellular_component chromatin binding chromatin chromosomal region chromosome organization chromosome, telomeric region cytosol damaged DNA binding decidualization defense response to other organism defense response developmental process involved in reproduction developmental process double-strand break repair envelope enzyme binding enzyme-linked receptor protein signaling pathway glycosyltransferase activity heterocycle biosynthetic process heterocycle metabolic process heterocyclic compound binding histone deacetylase binding identical protein binding immune response immune system process innate immune response intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle ion binding kinase binding leukocyte differentiation localization macromolecule biosynthetic process macromolecule localization macromolecule metabolic process macromolecule modification macrophage differentiation membrane-bounded organelle membrane metabolic process metal ion binding mitochondrial DNA metabolic process mitochondrial DNA repair mitochondrion organization mitochondrion molecular function activator activity molecular function regulator activity molecular_function myeloid cell differentiation myeloid leukocyte differentiation negative regulation of ATP biosynthetic process negative regulation of ATP metabolic process negative regulation of DNA metabolic process negative regulation of DNA-templated transcription, elongation negative regulation of DNA-templated transcription negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of adipose tissue development negative regulation of biological process negative regulation of biosynthetic process negative regulation of cGAS/STING signaling pathway negative regulation of cell communication negative regulation of cellular biosynthetic process negative regulation of cellular component organization negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of chromosome organization negative regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of defense response negative regulation of developmental process negative regulation of immune response negative regulation of immune system process negative regulation of innate immune response negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of nucleotide biosynthetic process negative regulation of nucleotide metabolic process negative regulation of organelle organization negative regulation of phosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of purine nucleotide biosynthetic process negative regulation of purine nucleotide metabolic process negative regulation of response to biotic stimulus negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of small molecule metabolic process negative regulation of telomere maintenance via telomere lengthening negative regulation of telomere maintenance negative regulation of transcription by RNA polymerase II negative regulation of transcription elongation by RNA polymerase II nitrogen compound metabolic process non-membrane-bounded organelle nuclear body nuclear envelope nuclear estrogen receptor binding nuclear receptor binding nuclear replication fork nucleic acid binding nucleic acid metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleolus nucleoplasm nucleoside phosphate binding nucleoside phosphate metabolic process nucleoside triphosphate metabolic process nucleosome binding nucleotide binding nucleotide metabolic process nucleotidyltransferase activity nucleus organelle envelope organelle organization organelle organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound metabolic process organophosphate metabolic process pentosyltransferase activity phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of DNA metabolic process positive regulation of DNA recombination positive regulation of DNA repair positive regulation of DNA-templated transcription, elongation positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of SMAD protein signal transduction positive regulation of biological process positive regulation of biosynthetic process positive regulation of canonical NF-kappaB signal transduction positive regulation of cardiac muscle hypertrophy positive regulation of cell communication positive regulation of cell differentiation positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of developmental process positive regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair positive regulation of intracellular estrogen receptor signaling pathway positive regulation of intracellular signal transduction positive regulation of intracellular steroid hormone receptor signaling pathway positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of membrane depolarization positive regulation of metabolic process positive regulation of mitochondrial depolarization positive regulation of multicellular organismal process positive regulation of muscle hypertrophy positive regulation of myofibroblast differentiation positive regulation of necroptotic process positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of programmed cell death positive regulation of programmed necrotic cell death positive regulation of protein localization to nucleus positive regulation of protein localization positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of single strand break repair positive regulation of transcription by RNA polymerase II positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway post-translational protein modification primary metabolic process programmed cell death protein auto-ADP-ribosylation protein autoprocessing protein binding protein dimerization activity protein homodimerization activity protein kinase binding protein localization to chromatin protein localization to chromosome protein localization to organelle protein localization protein maturation protein metabolic process protein modification process protein poly-ADP-ribosylation protein processing protein-DNA complex protein-containing complex binding protein-containing complex proteolysis purine nucleoside triphosphate metabolic process purine nucleotide binding purine nucleotide metabolic process purine ribonucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine-containing compound metabolic process regulation of ATP biosynthetic process regulation of ATP metabolic process regulation of DNA metabolic process regulation of DNA recombination regulation of DNA repair regulation of DNA-templated transcription elongation regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of SMAD protein signal transduction regulation of adipose tissue development regulation of apoptotic process regulation of apoptotic signaling pathway regulation of base-excision repair regulation of behavior regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of canonical NF-kappaB signal transduction regulation of cardiac muscle hypertrophy regulation of catalytic activity regulation of cell communication regulation of cell differentiation regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular localization regulation of cellular metabolic process regulation of cellular process regulation of cellular response to stress regulation of chromosome organization regulation of circadian rhythm regulation of circadian sleep/wake cycle, non-REM sleep regulation of circadian sleep/wake cycle, sleep regulation of circadian sleep/wake cycle regulation of cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of developmental process regulation of double-strand break repair via homologous recombination regulation of double-strand break repair regulation of gene expression regulation of immune response regulation of immune system process regulation of innate immune response regulation of intracellular estrogen receptor signaling pathway regulation of intracellular signal transduction regulation of intracellular steroid hormone receptor signaling pathway regulation of intrinsic apoptotic signaling pathway regulation of localization regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of membrane depolarization regulation of membrane potential regulation of metabolic process regulation of mitochondrial depolarization regulation of mitochondrial membrane potential regulation of molecular function regulation of multicellular organismal process regulation of muscle adaptation regulation of muscle hypertrophy regulation of muscle system process regulation of myofibroblast differentiation regulation of necroptotic process regulation of neuron apoptotic process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of nucleotide biosynthetic process regulation of nucleotide metabolic process regulation of organelle organization regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of pattern recognition receptor signaling pathway regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of primary metabolic process regulation of programmed cell death regulation of programmed necrotic cell death regulation of protein localization to nucleus regulation of protein localization regulation of purine nucleotide biosynthetic process regulation of purine nucleotide metabolic process regulation of response to biotic stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of signal transduction regulation of signaling regulation of single strand break repair regulation of small molecule metabolic process regulation of system process regulation of telomere maintenance via telomere lengthening regulation of telomere maintenance regulation of transcription by RNA polymerase II regulation of transcription elongation by RNA polymerase II regulation of transmembrane receptor protein serine/threonine kinase signaling pathway replication fork processing replication fork reversal replication fork reproductive process response to UV response to abiotic stimulus response to alcohol response to aldosterone response to amyloid-beta response to biotic stimulus response to chemical response to corticosteroid response to endogenous stimulus response to external biotic stimulus response to external stimulus response to gamma radiation response to growth factor response to hormone response to inorganic substance response to insulin response to ionizing radiation response to ketone response to light stimulus response to lipid response to metal ion response to mineralocorticoid response to nerve growth factor response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to other organism response to oxidative stress response to oxygen-containing compound response to peptide hormone response to peptide response to radiation response to steroid hormone response to stimulus response to stress response to zinc ion ribonucleoside triphosphate metabolic process ribonucleotide metabolic process ribose phosphate metabolic process signal transduction involved in regulation of gene expression signal transduction site of DNA damage site of double-strand break small molecule binding small molecule metabolic process telomere maintenance telomere organization tissue development transcription by RNA polymerase II transcription factor binding transcription regulator activator activity transcription regulator complex transferase activity, transferring phosphorus-containing groups transferase activity transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor superfamily signaling pathway transition metal ion binding transmembrane receptor protein serine/threonine kinase signaling pathway ubiquitin protein ligase binding ubiquitin-like protein ligase binding zinc ion binding	GO:0000018 GO:0000122 GO:0000166 GO:0000723 GO:0000781 GO:0000785 GO:0002376 GO:0002521 GO:0002573 GO:0002682 GO:0002683 GO:0002831 GO:0002832 GO:0003006 GO:0003254 GO:0003674 GO:0003676 GO:0003677 GO:0003682 GO:0003684 GO:0003723 GO:0003824 GO:0003950 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005635 GO:0005654 GO:0005657 GO:0005667 GO:0005730 GO:0005739 GO:0005829 GO:0005975 GO:0006139 GO:0006140 GO:0006163 GO:0006259 GO:0006281 GO:0006282 GO:0006302 GO:0006304 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0006508 GO:0006725 GO:0006753 GO:0006793 GO:0006796 GO:0006807 GO:0006915 GO:0006950 GO:0006952 GO:0006955 GO:0006974 GO:0006979 GO:0006996 GO:0007005 GO:0007165 GO:0007166 GO:0007167 GO:0007178 GO:0007179 GO:0008104 GO:0008134 GO:0008150 GO:0008152 GO:0008219 GO:0008270 GO:0009058 GO:0009059 GO:0009117 GO:0009141 GO:0009144 GO:0009150 GO:0009199 GO:0009205 GO:0009259 GO:0009314 GO:0009411 GO:0009416 GO:0009605 GO:0009607 GO:0009628 GO:0009719 GO:0009725 GO:0009888 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010033 GO:0010035 GO:0010038 GO:0010043 GO:0010212 GO:0010243 GO:0010332 GO:0010468 GO:0010556 GO:0010557 GO:0010558 GO:0010563 GO:0010569 GO:0010604 GO:0010605 GO:0010611 GO:0010613 GO:0010639 GO:0010646 GO:0010647 GO:0010648 GO:0012501 GO:0014070 GO:0014742 GO:0014743 GO:0016020 GO:0016043 GO:0016051 GO:0016070 GO:0016485 GO:0016540 GO:0016604 GO:0016740 GO:0016757 GO:0016763 GO:0016772 GO:0016779 GO:0016922 GO:0017076 GO:0018130 GO:0019219 GO:0019220 GO:0019222 GO:0019438 GO:0019538 GO:0019637 GO:0019693 GO:0019899 GO:0019900 GO:0019901 GO:0022414 GO:0023019 GO:0023051 GO:0023056 GO:0023057 GO:0030099 GO:0030154 GO:0030225 GO:0030331 GO:0030554 GO:0030592 GO:0030808 GO:0030809 GO:0031297 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031347 GO:0031348 GO:0031491 GO:0031625 GO:0031960 GO:0031967 GO:0031975 GO:0032042 GO:0032101 GO:0032102 GO:0032200 GO:0032204 GO:0032205 GO:0032502 GO:0032774 GO:0032784 GO:0032785 GO:0032786 GO:0032868 GO:0032869 GO:0032870 GO:0032879 GO:0032880 GO:0032991 GO:0032993 GO:0033036 GO:0033043 GO:0033044 GO:0033143 GO:0033145 GO:0033146 GO:0033148 GO:0033365 GO:0033554 GO:0033993 GO:0034243 GO:0034244 GO:0034502 GO:0034599 GO:0034641 GO:0034644 GO:0034654 GO:0035861 GO:0036094 GO:0036211 GO:0039531 GO:0039532 GO:0042221 GO:0042391 GO:0042749 GO:0042752 GO:0042802 GO:0042803 GO:0042826 GO:0042981 GO:0043067 GO:0043068 GO:0043122 GO:0043123 GO:0043167 GO:0043169 GO:0043170 GO:0043207 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043412 GO:0043434 GO:0043502 GO:0043504 GO:0043523 GO:0043596 GO:0043687 GO:0044057 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0044281 GO:0044389 GO:0044419 GO:0044877 GO:0045005 GO:0045087 GO:0045088 GO:0045187 GO:0045188 GO:0045595 GO:0045597 GO:0045739 GO:0045824 GO:0045892 GO:0045893 GO:0045911 GO:0045934 GO:0045935 GO:0045936 GO:0045944 GO:0045980 GO:0046034 GO:0046332 GO:0046483 GO:0046697 GO:0046872 GO:0046914 GO:0046983 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048545 GO:0048583 GO:0048584 GO:0048585 GO:0048856 GO:0048869 GO:0050776 GO:0050777 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050795 GO:0050896 GO:0051052 GO:0051053 GO:0051054 GO:0051093 GO:0051094 GO:0051128 GO:0051129 GO:0051171 GO:0051172 GO:0051173 GO:0051174 GO:0051179 GO:0051239 GO:0051240 GO:0051241 GO:0051252 GO:0051253 GO:0051254 GO:0051276 GO:0051287 GO:0051385 GO:0051604 GO:0051641 GO:0051707 GO:0051716 GO:0051881 GO:0051900 GO:0051901 GO:0055086 GO:0060255 GO:0060341 GO:0060390 GO:0060391 GO:0060544 GO:0060545 GO:0061629 GO:0062012 GO:0062014 GO:0062098 GO:0062100 GO:0062197 GO:0062207 GO:0065007 GO:0065008 GO:0065009 GO:0070212 GO:0070213 GO:0070412 GO:0070727 GO:0070848 GO:0070887 GO:0071168 GO:0071214 GO:0071241 GO:0071248 GO:0071294 GO:0071310 GO:0071363 GO:0071375 GO:0071417 GO:0071478 GO:0071482 GO:0071495 GO:0071704 GO:0071840 GO:0071932 GO:0072521 GO:0080090 GO:0080134 GO:0080135 GO:0090092 GO:0090100 GO:0090257 GO:0090304 GO:0090734 GO:0097159 GO:0097305 GO:0098542 GO:0098687 GO:0098772 GO:0104004 GO:0110165 GO:0140096 GO:0140294 GO:0140297 GO:0140537 GO:0140677 GO:0140805 GO:0140806 GO:0140807 GO:0140808 GO:0140815 GO:0140816 GO:0140817 GO:0140822 GO:0141091 GO:0160049 GO:1900180 GO:1900182 GO:1900371 GO:1900372 GO:1900542 GO:1900543 GO:1901135 GO:1901265 GO:1901360 GO:1901362 GO:1901363 GO:1901564 GO:1901576 GO:1901652 GO:1901653 GO:1901654 GO:1901698 GO:1901699 GO:1901700 GO:1901701 GO:1902175 GO:1902531 GO:1902533 GO:1902679 GO:1902680 GO:1903376 GO:1903516 GO:1903518 GO:1903578 GO:1903579 GO:1903829 GO:1904044 GO:1904177 GO:1904178 GO:1904181 GO:1904356 GO:1904357 GO:1904645 GO:1904646 GO:1904760 GO:1904762 GO:1905051 GO:1905168 GO:1990089 GO:1990090 GO:1990404 GO:1990966 GO:2000779 GO:2000781 GO:2001141 GO:2001169 GO:2001170 GO:2001233 GO:2001242 GO:2001251
143	poly(ADP-ribose) polymerase family member 4	PARP4 Aliases: ARTD4 VAULT3 VPARP VWA5C p193 vault poly(ADP-ribose) polymerase von Willebrand factor A domain containing 5C	Homo sapiens (human)	9606	Down syndrome breast cancer breast carcinoma cancer central nervous system lymphoma childhood leukemia colon cancer colonic benign neoplasm colorectal cancer embryoma esophagus squamous cell carcinoma goiter intracranial hypertension large intestine cancer leukemia lymphoma obsolete ymphosarcoma pancreatic cancer pancreatic carcinoma pseudotumor cerebri thyroid adenoma thyroid cancer thyroid gland carcinoma thyroid gland disease	DOID:0060058 DOID:11459 DOID:12176 DOID:1240 DOID:14250 DOID:1612 DOID:162 DOID:1781 DOID:1793 DOID:219 DOID:235 DOID:2891 DOID:3234 DOID:3459 DOID:3748 DOID:3963 DOID:4766 DOID:4905 DOID:50 DOID:5672 DOID:7757 DOID:8675 DOID:9256 DOID:9428	DNA binding DNA damage response DNA metabolic process DNA repair NAD+ ADP-ribosyltransferase activity NAD+-protein ADP-ribosyltransferase activity binding biological regulation biological_process catalytic activity, acting on a protein catalytic activity cellular anatomical entity cellular aromatic compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular response to stimulus cellular response to stress cellular_component cytoplasm cytosol defense response enzyme binding extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle glycosyltransferase activity heterocycle metabolic process inflammatory response intracellular membrane-bounded organelle intracellular organelle macromolecule metabolic process macromolecule modification membrane-bounded organelle membrane metabolic process microtubule molecular_function nitrogen compound metabolic process nucleic acid binding nucleic acid metabolic process nucleobase-containing compound metabolic process nucleoplasm nucleotidyltransferase activity nucleus organelle organic cyclic compound binding organic cyclic compound metabolic process organic substance metabolic process organonitrogen compound metabolic process pentosyltransferase activity polymeric cytoskeletal fiber primary metabolic process protein binding protein metabolic process protein modification process protein-containing complex regulation of DNA biosynthetic process regulation of DNA metabolic process regulation of biological process regulation of biosynthetic process regulation of catalytic activity regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of primary metabolic process regulation of telomerase activity regulation of transferase activity response to chemical response to stimulus response to stress response to xenobiotic stimulus ribonucleoprotein complex spindle microtubule supramolecular complex supramolecular fiber supramolecular polymer transferase activity, transferring phosphorus-containing groups transferase activity vesicle	GO:0003674 GO:0003676 GO:0003677 GO:0003824 GO:0003950 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005874 GO:0005876 GO:0006139 GO:0006259 GO:0006281 GO:0006725 GO:0006807 GO:0006950 GO:0006952 GO:0006954 GO:0006974 GO:0008150 GO:0008152 GO:0009410 GO:0009889 GO:0009987 GO:0010556 GO:0016020 GO:0016740 GO:0016757 GO:0016763 GO:0016772 GO:0016779 GO:0019219 GO:0019222 GO:0019538 GO:0019899 GO:0031323 GO:0031326 GO:0031982 GO:0032991 GO:0033554 GO:0034641 GO:0036211 GO:0042221 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043230 GO:0043231 GO:0043412 GO:0044237 GO:0044238 GO:0046483 GO:0050789 GO:0050790 GO:0050794 GO:0050896 GO:0051052 GO:0051171 GO:0051338 GO:0051716 GO:0051972 GO:0060255 GO:0065007 GO:0065009 GO:0065010 GO:0070062 GO:0071704 GO:0080090 GO:0090304 GO:0097159 GO:0099080 GO:0099081 GO:0099512 GO:0099513 GO:0110165 GO:0140096 GO:1901360 GO:1901564 GO:1903561 GO:1990404 GO:1990904 GO:2000278
146	adrenoceptor alpha 1D	ADRA1D	Homo sapiens (human)	9606			G protein-coupled amine receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor signaling pathway alpha-adrenergic receptor activity alpha1-adrenergic receptor activity binding biological regulation biological_process blood vessel diameter maintenance cell communication cell-cell signaling cellular anatomical entity cellular process cellular_component circulatory system process identical protein binding membrane molecular transducer activity molecular_function multicellular organismal process neuron-glial cell signaling phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane positive regulation of MAPK cascade positive regulation of biological process positive regulation of cell communication positive regulation of cell population proliferation positive regulation of cellular process positive regulation of cytosolic calcium ion concentration positive regulation of intracellular signal transduction positive regulation of multicellular organismal process positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of vasoconstriction protein binding regulation of MAPK cascade regulation of anatomical structure size regulation of biological process regulation of biological quality regulation of blood circulation regulation of cell communication regulation of cell population proliferation regulation of cellular process regulation of intracellular signal transduction regulation of multicellular organismal process regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of system process regulation of tube diameter regulation of tube size regulation of vasoconstriction signal transduction signaling receptor activity signaling system process transmembrane signaling receptor activity vascular process in circulatory system	GO:0003008 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0004930 GO:0004935 GO:0004936 GO:0004937 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0007154 GO:0007165 GO:0007186 GO:0007188 GO:0007189 GO:0007200 GO:0007204 GO:0007267 GO:0008150 GO:0008227 GO:0008284 GO:0009966 GO:0009967 GO:0009987 GO:0010646 GO:0010647 GO:0016020 GO:0019229 GO:0023051 GO:0023052 GO:0023056 GO:0032501 GO:0035150 GO:0035296 GO:0038023 GO:0042127 GO:0042802 GO:0043408 GO:0043410 GO:0044057 GO:0045907 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0050789 GO:0050794 GO:0051239 GO:0051240 GO:0060089 GO:0065007 GO:0065008 GO:0071875 GO:0071880 GO:0090066 GO:0097746 GO:0110165 GO:0150099 GO:1902531 GO:1902533 GO:1903522
147	adrenoceptor alpha 1B	ADRA1B	Homo sapiens (human)	9606			G protein-coupled amine receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor signaling pathway alpha-adrenergic receptor activity alpha1-adrenergic receptor activity binding biological regulation biological_process blood vessel diameter maintenance caveola cell communication cell-cell signaling cellular anatomical entity cellular process cellular_component circulatory system process cytoplasm intracellular membrane-bounded organelle intracellular organelle intracellular signal transduction membrane microdomain membrane raft membrane-bounded organelle membrane molecular transducer activity molecular_function multicellular organismal process neuron-glial cell signaling nuclear membrane nucleus organelle membrane organelle phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane raft plasma membrane region plasma membrane positive regulation of MAPK cascade positive regulation of biological process positive regulation of cell communication positive regulation of cellular process positive regulation of cytosolic calcium ion concentration positive regulation of intracellular signal transduction positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling protein binding protein dimerization activity protein heterodimerization activity regulation of MAPK cascade regulation of anatomical structure size regulation of biological process regulation of biological quality regulation of blood circulation regulation of cardiac muscle contraction regulation of cell communication regulation of cellular process regulation of heart contraction regulation of intracellular signal transduction regulation of multicellular organismal process regulation of muscle contraction regulation of muscle system process regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of striated muscle contraction regulation of system process regulation of tube diameter regulation of tube size regulation of vasoconstriction signal transduction signaling receptor activity signaling system process transmembrane signaling receptor activity vascular process in circulatory system	GO:0003008 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0004930 GO:0004935 GO:0004936 GO:0004937 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005737 GO:0005886 GO:0005901 GO:0006937 GO:0006942 GO:0007154 GO:0007165 GO:0007186 GO:0007188 GO:0007189 GO:0007200 GO:0007204 GO:0007267 GO:0008016 GO:0008150 GO:0008227 GO:0009966 GO:0009967 GO:0009987 GO:0010646 GO:0010647 GO:0016020 GO:0019229 GO:0023051 GO:0023052 GO:0023056 GO:0031090 GO:0031965 GO:0032501 GO:0035150 GO:0035296 GO:0035556 GO:0038023 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043408 GO:0043410 GO:0044057 GO:0044853 GO:0045121 GO:0046982 GO:0046983 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0050789 GO:0050794 GO:0051239 GO:0055117 GO:0060089 GO:0065007 GO:0065008 GO:0071875 GO:0071880 GO:0090066 GO:0090257 GO:0097746 GO:0098590 GO:0098857 GO:0110165 GO:0150099 GO:1902531 GO:1902533 GO:1903522
148	adrenoceptor alpha 1A	ADRA1A	Homo sapiens (human)	9606			G protein-coupled amine receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway MAPK cascade adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor activity adrenergic receptor signaling pathway adult heart development alpha-adrenergic receptor activity alpha1-adrenergic receptor activity anatomical structure development animal organ development apoptotic process binding biological regulation biological_process blood vessel diameter maintenance calcium ion transmembrane import into cytosol calcium ion transmembrane transport calcium ion transport into cytosol calcium ion transport caveola cell communication cell death cell growth involved in cardiac muscle cell development cell growth cell-cell signaling cellular anatomical entity cellular process cellular_component circulatory system process cytoplasm cytosol developmental cell growth developmental growth developmental process establishment of localization growth heart development inorganic cation transmembrane transport inorganic ion transmembrane transport intracellular membrane-bounded organelle intracellular organelle intracellular signal transduction localization membrane microdomain membrane raft membrane-bounded organelle membrane metal ion transport modulation of chemical synaptic transmission molecular transducer activity molecular_function monoatomic cation transmembrane transport monoatomic cation transport monoatomic ion transmembrane transport monoatomic ion transport multicellular organismal process muscle contraction muscle system process negative regulation of autophagy negative regulation of biological process negative regulation of blood circulation negative regulation of catabolic process negative regulation of cell population proliferation negative regulation of cellular catabolic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of heart contraction negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure negative regulation of heart rate negative regulation of metabolic process negative regulation of multicellular organismal process neuron-glial cell signaling norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure nuclear membrane nucleoplasm nucleus organelle membrane organelle organic substance transport phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway pilomotor reflex plasma membrane raft plasma membrane region plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade positive regulation of action potential positive regulation of biological process positive regulation of blood circulation positive regulation of cardiac muscle contraction positive regulation of cardiac muscle hypertrophy positive regulation of cell communication positive regulation of cellular process positive regulation of cytosolic calcium ion concentration positive regulation of heart contraction positive regulation of heart rate by epinephrine-norepinephrine positive regulation of heart rate positive regulation of intracellular signal transduction positive regulation of multicellular organismal process positive regulation of muscle contraction positive regulation of muscle hypertrophy positive regulation of protein kinase C signaling positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of smooth muscle contraction positive regulation of striated muscle contraction positive regulation of synaptic transmission, GABAergic positive regulation of synaptic transmission positive regulation of the force of heart contraction by chemical signal positive regulation of the force of heart contraction by epinephrine-norepinephrine positive regulation of vasoconstriction programmed cell death protein binding protein dimerization activity protein heterodimerization activity reflex regulation of ERK1 and ERK2 cascade regulation of MAPK cascade

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