GlyCosmos Portal

GlyCosmos Genes

Integrated list of glycan-related genes extracted KEGG GENES Database, UniProt, GlycoGene Database (GGDB), Plant GARDEN and FlyGlycoDB. Glycan-related genes including glycosyltransferase, hydrolase activity (acting on glycosyl bonds), carbohydrate metabolic process, etc .

Source	Last Updated
FlyGlycoDB	March 25, 2024
GlycoGene Database (GGDB)	January 26, 2018
KEGG GENES Database	September 20, 2023
Plant GARDEN	May 28, 2020
UniProt	October 29, 2024

Selecting the function you want to look up from the categories displays a list narrowed down to glycan-related genes with that function (Gene Ontology).

Catalytic activity

glycosyltransferase activity

hydrolase activity, acting on glycosyl bonds

Binding

carbohydrate binding

Response to carbohydrate

Primary metabolic process

Displaying entries **101 - 125** of **9988** in total

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Gene ID ▲	Gene Name	Gene Symbol	Organism	Taxonomy ID	Disease Ontology	Disease Ontology ID	Gene Ontology	Gene Ontology ID
167	cysteine rich secretory protein 1	CRISP1	Homo sapiens (human)	9606			binding of sperm to zona pellucida biological regulation biological_process calcium channel regulator activity cell recognition cell-cell recognition cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular process involved in reproduction in multicellular organism cellular process cellular_component channel regulator activity extracellular space fusion of sperm to egg plasma membrane involved in single fertilization intracellular membrane-bounded organelle intracellular organelle ion channel regulator activity membrane fusion membrane organization membrane-bounded organelle molecular function regulator activity molecular_function nucleus organelle plasma membrane fusion plasma membrane organization regulation of acrosome reaction regulation of biological process regulation of reproductive process reproductive process sperm-egg recognition transporter regulator activity	GO:0003674 GO:0005246 GO:0005575 GO:0005615 GO:0005634 GO:0007009 GO:0007339 GO:0007342 GO:0008037 GO:0008150 GO:0009987 GO:0009988 GO:0016043 GO:0016247 GO:0022412 GO:0022414 GO:0035036 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0045026 GO:0050789 GO:0060046 GO:0061024 GO:0061025 GO:0065007 GO:0071840 GO:0098772 GO:0099106 GO:0110165 GO:0141108 GO:2000241
173	afamin	AFM	Homo sapiens (human)	9606			binding biological regulation biological_process blood microparticle cellular anatomical entity cellular localization cellular macromolecule localization cellular process cellular_component cytoplasm establishment of localization establishment of protein localization to extracellular region establishment of protein localization extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular region extracellular space extracellular vesicle heterocyclic compound binding localization macromolecule localization membrane-bounded organelle molecular_function nitrogen compound transport organelle organic cyclic compound binding organic substance transport protein binding protein localization to extracellular region protein localization protein stabilization protein transport within extracellular region protein transport regulation of biological quality regulation of protein stability small molecule binding transport vesicle vitamin E binding vitamin binding vitamin transport	GO:0003674 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0005737 GO:0006810 GO:0008104 GO:0008150 GO:0008431 GO:0009987 GO:0015031 GO:0019842 GO:0031647 GO:0031982 GO:0033036 GO:0035592 GO:0036094 GO:0043226 GO:0043227 GO:0043230 GO:0045184 GO:0050821 GO:0051179 GO:0051180 GO:0051234 GO:0051641 GO:0065007 GO:0065008 GO:0065010 GO:0070062 GO:0070727 GO:0071692 GO:0071693 GO:0071702 GO:0071705 GO:0072562 GO:0097159 GO:0110165 GO:1901363 GO:1903561
174	alpha fetoprotein	AFP	Homo sapiens (human)	9606			C21-steroid hormone metabolic process apoptotic process binding biological regulation biological_process cation binding cell death cellular anatomical entity cellular ketone metabolic process cellular metabolic process cellular process cellular_component cytoplasm endoplasmic reticulum lumen extracellular space homeostasis of number of cells homeostatic process hormone metabolic process immune response immune system process intracellular organelle lumen ion binding lipid metabolic process membrane-enclosed lumen metabolic process metal ion binding molecular_function multicellular organismal process multicellular organismal reproductive process multicellular organismal-level homeostasis olefinic compound metabolic process organelle lumen organic cyclic compound metabolic process organic substance metabolic process ovulation cycle process ovulation from ovarian follicle ovulation primary metabolic process progesterone metabolic process programmed cell death protein binding regulation of biological quality regulation of hormone levels reproductive process response to stimulus rhythmic process small molecule binding small molecule metabolic process steroid metabolic process	GO:0001542 GO:0002376 GO:0003674 GO:0005488 GO:0005515 GO:0005575 GO:0005615 GO:0005737 GO:0005788 GO:0006629 GO:0006915 GO:0006955 GO:0008150 GO:0008152 GO:0008202 GO:0008207 GO:0008219 GO:0009987 GO:0010817 GO:0012501 GO:0022414 GO:0022602 GO:0030728 GO:0031974 GO:0032501 GO:0036094 GO:0042180 GO:0042445 GO:0042448 GO:0042592 GO:0043167 GO:0043169 GO:0043233 GO:0044237 GO:0044238 GO:0044281 GO:0046872 GO:0048511 GO:0048609 GO:0048871 GO:0048872 GO:0050896 GO:0065007 GO:0065008 GO:0070013 GO:0071704 GO:0110165 GO:0120254 GO:1901360
175	aspartylglucosaminidase	AGA Aliases: ASRG N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase glycosylasparaginase	Homo sapiens (human)	9606	Clostridium difficile colitis Down syndrome Fabry disease Klippel-Feil syndrome Laron syndrome abdominal obesity-metabolic syndrome 1 achalasia achondroplasia acne acrodermatitis agranulocytosis alcoholic hepatitis allergic bronchopulmonary aspergillosis alopecia androgenic alopecia arthritis arthropathy aspartylglucosaminuria attention deficit hyperactivity disorder cancer cataract celiac disease cerebral degeneration cervical squamous cell carcinoma cholecystitis chylomicron retention disease clubfoot common wart congenital disorder of glycosylation craniosynostosis dental caries dentin caries dermatitis herpetiformis diabetes mellitus diabetic ketoacidosis diarrhea dystonia encephalitis encephalomyelitis enterocele eosinophilic esophagitis epilepsy esophageal disease familial isolated hypoparathyroidism fucosidosis functional diarrhea gestational diabetes gingival hypertrophy gingival overgrowth goiter hepatitis C hepatocellular carcinoma hypoparathyroidism immunoglobulin alpha deficiency inflammatory bowel disease 1 inflammatory bowel disease influenza inguinal hernia intellectual disability irritable bowel syndrome learning disability lingual-facial-buccal dyskinesia lipid storage disease livedoid vasculitis liver cancer liver cirrhosis lupus nephritis lysosomal storage disease megaesophagus microcephaly mitral valve insufficiency mitral valve prolapse mucopolysaccharidosis I mucopolysaccharidosis II mucopolysaccharidosis III mucopolysaccharidosis IV mucopolysaccharidosis Ih mucopolysaccharidosis VI mucopolysaccharidosis multiple sclerosis myelitis neurocirculatory asthenia neutropenia obsolete dyspepsia obsolete type 1 diabetes mellitus 9 omphalocele otitis media peroxisome biogenesis disorder 10A placental insufficiency primary sclerosing cholangitis schizoaffective disorder schizophrenia schizophreniform disorder sclerosing cholangitis scoliosis selective IgA deficiency disease severe congenital neutropenia skeletal tuberculosis speech disorder spondylolisthesis spondylolysis stomach cancer stomach carcinoma stomach disease thyroid gland disease tropical sprue tuberculosis type 1 diabetes mellitus 10 type 1 diabetes mellitus 11 type 1 diabetes mellitus 12 type 1 diabetes mellitus 13 type 1 diabetes mellitus 15 type 1 diabetes mellitus 17 type 1 diabetes mellitus 18 type 1 diabetes mellitus 19 type 1 diabetes mellitus 20 type 1 diabetes mellitus 21 type 1 diabetes mellitus 22 type 1 diabetes mellitus 23 type 1 diabetes mellitus 24 type 1 diabetes mellitus 2 type 1 diabetes mellitus 3 type 1 diabetes mellitus 4 type 1 diabetes mellitus 5 type 1 diabetes mellitus 6 type 1 diabetes mellitus 7 type 1 diabetes mellitus 8 type 1 diabetes mellitus type 2 diabetes mellitus ulcerative colitis umbilical hernia vascular skin disease visual epilepsy	DOID:0040099 DOID:0050461 DOID:0050589 DOID:0050590 DOID:0050801 DOID:0060025 DOID:0060185 DOID:0060249 DOID:0060320 DOID:0060321 DOID:0060327 DOID:0060357 DOID:0060643 DOID:0080162 DOID:0080484 DOID:0110741 DOID:0110742 DOID:0110743 DOID:0110744 DOID:0110745 DOID:0110746 DOID:0110747 DOID:0110748 DOID:0110749 DOID:0110750 DOID:0110751 DOID:0110752 DOID:0110753 DOID:0110754 DOID:0110755 DOID:0110756 DOID:0110757 DOID:0110758 DOID:0110759 DOID:0110760 DOID:0110761 DOID:0110892 DOID:0111387 DOID:0111390 DOID:10426 DOID:10461 DOID:10534 DOID:1059 DOID:10607 DOID:10608 DOID:10754 DOID:10907 DOID:1094 DOID:11165 DOID:11199 DOID:11328 DOID:11371 DOID:11502 DOID:11569 DOID:11701 DOID:11714 DOID:11832 DOID:11836 DOID:12176 DOID:1227 DOID:12351 DOID:12798 DOID:12799 DOID:12800 DOID:12801 DOID:12802 DOID:12804 DOID:1283 DOID:12987 DOID:13166 DOID:13186 DOID:13250 DOID:13922 DOID:14221 DOID:14250 DOID:14268 DOID:1443 DOID:14499 DOID:14500 DOID:162 DOID:1639 DOID:1826 DOID:1837 DOID:1883 DOID:1949 DOID:216 DOID:2300 DOID:2321 DOID:2340 DOID:2377 DOID:2722 DOID:3086 DOID:3211 DOID:322 DOID:3571 DOID:3744 DOID:381 DOID:3891 DOID:399 DOID:4480 DOID:50 DOID:5082 DOID:5212 DOID:5338 DOID:5418 DOID:5419 DOID:543 DOID:5517 DOID:6050 DOID:640 DOID:6543 DOID:6682 DOID:684 DOID:76 DOID:83 DOID:8469 DOID:848 DOID:8505 DOID:8577 DOID:8927 DOID:9164 DOID:92 DOID:9351 DOID:9352 DOID:9455 DOID:9521 DOID:9540 DOID:9588 DOID:9744 DOID:9778 DOID:9854 DOID:987 DOID:988	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity azurophil granule lumen binding biological_process carbohydrate derivative metabolic process catalytic activity, acting on a protein catalytic activity cellular anatomical entity cellular_component cytoplasm cytoplasmic vesicle lumen endoplasmic reticulum extracellular region extracellular space glycoprotein metabolic process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle lysosome lytic vacuole macromolecule metabolic process macromolecule modification membrane-bounded organelle membrane-enclosed lumen metabolic process molecular_function nitrogen compound metabolic process organelle lumen organelle organic substance metabolic process organonitrogen compound metabolic process peptidase activity primary metabolic process protein binding protein deglycosylation protein metabolic process protein modification process proteolysis secretory granule lumen vacuolar lumen vacuole vesicle lumen	GO:0000323 GO:0003674 GO:0003824 GO:0003948 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0005737 GO:0005764 GO:0005773 GO:0005775 GO:0005783 GO:0006508 GO:0006517 GO:0006807 GO:0008150 GO:0008152 GO:0008233 GO:0009100 GO:0016787 GO:0016810 GO:0016811 GO:0019538 GO:0031974 GO:0031983 GO:0034774 GO:0035578 GO:0036211 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0043412 GO:0044238 GO:0060205 GO:0070013 GO:0071704 GO:0110165 GO:0140096 GO:1901135 GO:1901564
176	aggrecan	ACAN Aliases: CSPGCP aggrecan proteoglycan	Homo sapiens (human)	9606	Bannayan-Riley-Ruvalcaba syndrome Cowden syndrome Dowling-Degos disease Ehlers-Danlos syndrome Laron syndrome Lyme disease Marfan syndrome SADDAN Silverman-Handmaker type dyssegmental dysplasia Werner syndrome X-linked spondyloepiphyseal dysplasia tarda achondroplasia actinic keratosis amyloidosis anthracosilicosis aortic valve disease 1 aortic valve disease 2 aortic valve disease aortic valve stenosis arteriolosclerosis arteriosclerosis arteriosclerotic cardiovascular disease arthritis arthropathy asbestosis atherosclerosis autism spectrum disorder autistic disorder autoimmune disease autoimmune lymphoproliferative syndrome autosomal dominant limb-girdle muscular dystrophy type 1 autosomal dominant limb-girdle muscular dystrophy type 1H autosomal dominant limb-girdle muscular dystrophy type 2 autosomal dominant limb-girdle muscular dystrophy type 3 autosomal dominant limb-girdle muscular dystrophy autosomal recessive limb-girdle muscular dystrophy type 2A autosomal recessive limb-girdle muscular dystrophy type 2B autosomal recessive limb-girdle muscular dystrophy type 2C autosomal recessive limb-girdle muscular dystrophy type 2D autosomal recessive limb-girdle muscular dystrophy type 2E autosomal recessive limb-girdle muscular dystrophy type 2F autosomal recessive limb-girdle muscular dystrophy type 2G autosomal recessive limb-girdle muscular dystrophy type 2H autosomal recessive limb-girdle muscular dystrophy type 2I autosomal recessive limb-girdle muscular dystrophy type 2J autosomal recessive limb-girdle muscular dystrophy type 2K autosomal recessive limb-girdle muscular dystrophy type 2L autosomal recessive limb-girdle muscular dystrophy type 2M autosomal recessive limb-girdle muscular dystrophy type 2N autosomal recessive limb-girdle muscular dystrophy type 2O autosomal recessive limb-girdle muscular dystrophy type 2P autosomal recessive limb-girdle muscular dystrophy type 2Q autosomal recessive limb-girdle muscular dystrophy type 2S autosomal recessive limb-girdle muscular dystrophy type 2T autosomal recessive limb-girdle muscular dystrophy type 2U autosomal recessive limb-girdle muscular dystrophy type 2Y autosomal recessive limb-girdle muscular dystrophy bagassosis bicuspid aortic valve disease bone disease cancer cardiovascular system disease carpal tunnel syndrome cartilage disease cerebral infarction cerebrovascular disease cherubism chondroblastoma chondromalacia chondrosarcoma chordoma chorioamnionitis chronic interstitial cystitis ciliary body disease colon cancer colonic benign neoplasm colorectal cancer congestive heart failure connective tissue disease coronary artery disease degenerative disc disease dental fluorosis developmental and epileptic encephalopathy 39 diabetic ketoacidosis distal myopathy enterocele epithelioid sarcoma exostosis facioscapulohumeral muscular dystrophy 1 facioscapulohumeral muscular dystrophy heart disease hepatocellular carcinoma hereditary multiple exostoses hypochondroplasia hypogonadism hypogonadotropic hypogonadism 7 with or without anosmia immune system disease infantile myofibromatosis interstitial cystitis iris disease juvenile rheumatoid arthritis large intestine cancer laryngeal carcinoma laryngeal disease larynx cancer limb-girdle muscular dystrophy lipoma liver cancer mucopolysaccharidosis II mucopolysaccharidosis III mucopolysaccharidosis IV mucopolysaccharidosis VI mucopolysaccharidosis multiple epiphyseal dysplasia multiple sclerosis multiple symmetric lipomatosis muscular dystrophy neurogenic arthropathy nicotine dependence obesity obsessive-compulsive disorder obsessive-compulsive personality disorder obsolete autosomal dominant limb-girdle muscular dystrophy type 1A obsolete autosomal dominant limb-girdle muscular dystrophy type 1B obsolete autosomal dominant limb-girdle muscular dystrophy type 1C obsolete autosomal recessive limb-girdle muscular dystrophy type 2R obsolete type 1 diabetes mellitus 9 oculopharyngeal muscular dystrophy osteoarthritis osteochondritis dissecans osteochondrodysplasia osteogenesis imperfecta panuveitis periarthritis peroxisome biogenesis disorder 5A pleomorphic lipoma pneumoconiosis polycystic ovary syndrome progeria progressive pseudorheumatoid arthropathy of childhood prune belly syndrome pseudoachondroplasia reticulate acropigmentation of Kitamura rheumatoid arthritis sarcoma schizophrenia scoliosis septic arthritis siderosis situs inversus spindle cell sarcoma spondylitis spondyloarthropathy spondyloepiphyseal dysplasia Kimberley type spondyloepiphyseal dysplasia congenita spondylosis status epilepticus tendinitis tracheal disease tropical spastic paraparesis tuberous sclerosis type 1 diabetes mellitus 10 type 1 diabetes mellitus 11 type 1 diabetes mellitus 12 type 1 diabetes mellitus 13 type 1 diabetes mellitus 15 type 1 diabetes mellitus 17 type 1 diabetes mellitus 18 type 1 diabetes mellitus 19 type 1 diabetes mellitus 20 type 1 diabetes mellitus 21 type 1 diabetes mellitus 22 type 1 diabetes mellitus 23 type 1 diabetes mellitus 24 type 1 diabetes mellitus 2 type 1 diabetes mellitus 3 type 1 diabetes mellitus 4 type 1 diabetes mellitus 5 type 1 diabetes mellitus 6 type 1 diabetes mellitus 7 type 1 diabetes mellitus 8 type 1 diabetes mellitus uveitis	DOID:0050657 DOID:0050697 DOID:0050742 DOID:0060041 DOID:0060249 DOID:0060256 DOID:0060258 DOID:0060889 DOID:0080001 DOID:0080041 DOID:0080047 DOID:0080109 DOID:0080332 DOID:0080333 DOID:0080334 DOID:0080349 DOID:0080362 DOID:0080480 DOID:0090004 DOID:0090032 DOID:0090078 DOID:0110273 DOID:0110274 DOID:0110275 DOID:0110276 DOID:0110277 DOID:0110278 DOID:0110279 DOID:0110280 DOID:0110281 DOID:0110282 DOID:0110283 DOID:0110284 DOID:0110285 DOID:0110286 DOID:0110287 DOID:0110289 DOID:0110292 DOID:0110293 DOID:0110294 DOID:0110295 DOID:0110296 DOID:0110297 DOID:0110298 DOID:0110299 DOID:0110300 DOID:0110301 DOID:0110302 DOID:0110303 DOID:0110304 DOID:0110305 DOID:0110306 DOID:0110741 DOID:0110742 DOID:0110743 DOID:0110744 DOID:0110745 DOID:0110746 DOID:0110747 DOID:0110748 DOID:0110749 DOID:0110750 DOID:0110751 DOID:0110752 DOID:0110753 DOID:0110754 DOID:0110755 DOID:0110756 DOID:0110757 DOID:0110758 DOID:0110759 DOID:0110760 DOID:0110761 DOID:0111158 DOID:0111192 DOID:0112282 DOID:10192 DOID:10316 DOID:10320 DOID:10324 DOID:10328 DOID:10932 DOID:10933 DOID:1115 DOID:1123 DOID:114 DOID:11612 DOID:11719 DOID:11720 DOID:11724 DOID:11727 DOID:11729 DOID:12030 DOID:12169 DOID:1222 DOID:12347 DOID:12522 DOID:12721 DOID:12798 DOID:12799 DOID:12800 DOID:12801 DOID:12804 DOID:1283 DOID:12849 DOID:1287 DOID:13141 DOID:13359 DOID:13515 DOID:13711 DOID:13949 DOID:14116 DOID:14286 DOID:14323 DOID:14789 DOID:162 DOID:1678 DOID:1712 DOID:1824 DOID:1837 DOID:1856 DOID:1924 DOID:1936 DOID:203 DOID:206 DOID:219 DOID:2247 DOID:2256 DOID:2348 DOID:2349 DOID:235 DOID:2377 DOID:240 DOID:2557 DOID:2596 DOID:2600 DOID:2649 DOID:2914 DOID:2964 DOID:321 DOID:3225 DOID:3302 DOID:3315 DOID:3371 DOID:3393 DOID:3526 DOID:3571 DOID:381 DOID:3911 DOID:417 DOID:4235 DOID:4353 DOID:4480 DOID:5162 DOID:5419 DOID:5672 DOID:5688 DOID:6000 DOID:6193 DOID:62 DOID:6457 DOID:65 DOID:6590 DOID:6688 DOID:6713 DOID:676 DOID:684 DOID:7148 DOID:758 DOID:786 DOID:813 DOID:8398 DOID:84 DOID:848 DOID:8866 DOID:90 DOID:9120 DOID:9256 DOID:9521 DOID:971 DOID:9744 DOID:9884 DOID:9970	Golgi lumen anatomical structure development binding biological regulation biological_process carbohydrate binding carbohydrate derivative binding cation binding cell adhesion cell differentiation cell junction cellular anatomical entity cellular developmental process cellular process cellular_component central nervous system development collagen-containing extracellular matrix developmental process external encapsulating structure extracellular matrix structural constituent conferring compression resistance extracellular matrix structural constituent extracellular matrix extracellular region extracellular space glial cell differentiation glycosaminoglycan binding hyaluronic acid binding intracellular organelle lumen ion binding lysosomal lumen macromolecule metabolic process membrane-enclosed lumen metabolic process metal ion binding molecular_function nitrogen compound metabolic process organelle lumen organic substance metabolic process organonitrogen compound metabolic process perineuronal net perisynaptic extracellular matrix positive regulation of biological process positive regulation of cell development positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of cellular process positive regulation of developmental process positive regulation of multicellular organismal process positive regulation of nervous system development positive regulation of neural precursor cell proliferation positive regulation of neuroblast proliferation positive regulation of neurogenesis primary metabolic process protein binding protein metabolic process proteolysis regulation of biological process regulation of cell development regulation of cell differentiation regulation of cell population proliferation regulation of cellular process regulation of developmental process regulation of multicellular organismal development regulation of multicellular organismal process regulation of nervous system development regulation of neural precursor cell proliferation regulation of neuroblast proliferation regulation of neurogenesis skeletal system development structural molecule activity synapse system development vacuolar lumen	GO:0001501 GO:0002052 GO:0003674 GO:0005198 GO:0005201 GO:0005488 GO:0005515 GO:0005539 GO:0005540 GO:0005575 GO:0005576 GO:0005615 GO:0005775 GO:0005796 GO:0006508 GO:0006807 GO:0007155 GO:0007417 GO:0008150 GO:0008152 GO:0008284 GO:0009987 GO:0010001 GO:0010720 GO:0019538 GO:0030021 GO:0030054 GO:0030154 GO:0030246 GO:0030312 GO:0031012 GO:0031974 GO:0032502 GO:0042127 GO:0043167 GO:0043169 GO:0043170 GO:0043202 GO:0043233 GO:0044238 GO:0045202 GO:0045595 GO:0045597 GO:0046872 GO:0048518 GO:0048522 GO:0048731 GO:0048856 GO:0048869 GO:0050767 GO:0050769 GO:0050789 GO:0050793 GO:0050794 GO:0051094 GO:0051239 GO:0051240 GO:0051960 GO:0051962 GO:0060284 GO:0062023 GO:0065007 GO:0070013 GO:0071704 GO:0072534 GO:0097367 GO:0098966 GO:0110165 GO:1901564 GO:1902692 GO:2000026 GO:2000177 GO:2000179
177	advanced glycosylation end-product specific receptor	AGER	Homo sapiens (human)	9606			S100 protein binding advanced glycation end-product receptor activity amide binding amyloid-beta binding apical plasma membrane astrocyte activation behavior binding biological regulation biological_process carbohydrate mediated signaling cargo receptor activity cell activation cell adhesion mediator activity cell adhesion molecule binding cell adhesion cell junction cell projection organization cell surface receptor signaling pathway cell surface cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular localization cellular macromolecule localization cellular process cellular response to amyloid-beta cellular response to chemical stimulus cellular response to endogenous stimulus cellular response to nitrogen compound cellular response to organic substance cellular response to organonitrogen compound cellular response to oxygen-containing compound cellular response to peptide cellular response to stimulus cellular_component circulatory system process cognition defense response establishment of localization extracellular region fibrillar center glial cell activation glucose mediated signaling pathway hexose mediated signaling identical protein binding immune system process induction of positive chemotaxis inflammatory response laminin receptor activity learning or memory leukocyte activation involved in inflammatory response leukocyte activation localization within membrane localization macromolecule localization macrophage activation membrane microglial cell activation modulation of chemical synaptic transmission molecular adaptor activity molecular transducer activity molecular_function multicellular organismal process myeloid leukocyte activation negative regulation of biological process negative regulation of biosynthetic process negative regulation of blood circulation negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of connective tissue replacement involved in inflammatory response wound healing negative regulation of connective tissue replacement negative regulation of cytokine production negative regulation of gene expression negative regulation of interleukin-10 production negative regulation of long-term synaptic depression negative regulation of long-term synaptic potentiation negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process negative regulation of tissue remodeling nervous system process neuron projection development peptide binding plasma membrane bounded cell projection organization plasma membrane region plasma membrane positive regulation of DNA-binding transcription factor activity positive regulation of ERK1 and ERK2 cascade positive regulation of JNK cascade positive regulation of MAPK cascade positive regulation of NF-kappaB transcription factor activity positive regulation of T cell activation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of amyloid precursor protein catabolic process positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of aspartic-type peptidase activity positive regulation of biological process positive regulation of biosynthetic process positive regulation of catalytic activity positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell communication positive regulation of cell development positive regulation of cell differentiation positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular extravasation positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of chemokine production positive regulation of chemotaxis positive regulation of cytokine production positive regulation of dendritic cell differentiation positive regulation of developmental process positive regulation of endopeptidase activity positive regulation of endothelin production positive regulation of gene expression positive regulation of hemopoiesis positive regulation of heterotypic cell-cell adhesion positive regulation of hydrolase activity positive regulation of immune system process positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of intracellular signal transduction positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte differentiation positive regulation of leukocyte migration positive regulation of leukocyte proliferation positive regulation of locomotion positive regulation of lymphocyte activation positive regulation of lymphocyte proliferation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of monocyte chemotactic protein-1 production positive regulation of monocyte extravasation positive regulation of mononuclear cell migration positive regulation of mononuclear cell proliferation positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of non-canonical NF-kappaB signal transduction positive regulation of p38MAPK cascade positive regulation of peptidase activity positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of positive chemotaxis positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of proteolysis positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of stress-activated MAPK cascade positive regulation of stress-activated protein kinase signaling cascade positive regulation of synaptic transmission positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production postsynapse protein binding protein localization to membrane protein localization protein-containing complex binding regulation of CD4-positive, alpha-beta T cell activation regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of ERK1 and ERK2 cascade regulation of JNK cascade regulation of MAPK cascade regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of T cell activation regulation of T cell mediated cytotoxicity regulation of T cell mediated immunity regulation of T cell proliferation regulation of activated T cell proliferation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of alpha-beta T cell activation regulation of amyloid precursor protein catabolic process regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process regulation of aspartic-type peptidase activity regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of blood circulation regulation of catalytic activity regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell development regulation of cell differentiation regulation of cell killing regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular extravasation regulation of cellular metabolic process regulation of cellular process regulation of cellular response to stress regulation of chemokine production regulation of chemotaxis regulation of connective tissue replacement involved in inflammatory response wound healing regulation of connective tissue replacement regulation of cytokine production regulation of defense response regulation of dendritic cell differentiation regulation of developmental process regulation of endopeptidase activity regulation of endothelin production regulation of gene expression regulation of hemopoiesis regulation of heterotypic cell-cell adhesion regulation of hydrolase activity regulation of immune effector process regulation of immune response regulation of immune system process regulation of inflammatory response regulation of interleukin-1 beta production regulation of interleukin-1 production regulation of interleukin-10 production regulation of interleukin-12 production regulation of interleukin-6 production regulation of intracellular signal transduction regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of leukocyte mediated cytotoxicity regulation of leukocyte mediated immunity regulation of leukocyte migration regulation of leukocyte proliferation regulation of locomotion regulation of long-term synaptic depression regulation of long-term synaptic potentiation regulation of lymphocyte activation regulation of lymphocyte mediated immunity regulation of lymphocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of monocyte chemotactic protein-1 production regulation of monocyte extravasation regulation of mononuclear cell migration regulation of mononuclear cell proliferation regulation of multicellular organismal development regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of non-canonical NF-kappaB signal transduction regulation of nucleobase-containing compound metabolic process regulation of p38MAPK cascade regulation of peptidase activity regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of positive chemotaxis regulation of primary metabolic process regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of proteolysis regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of signal transduction regulation of signaling regulation of spontaneous synaptic transmission regulation of stress-activated MAPK cascade regulation of stress-activated protein kinase signaling cascade regulation of synaptic plasticity regulation of system process regulation of tissue remodeling regulation of trans-synaptic signaling regulation of tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production response to abiotic stimulus response to amyloid-beta response to chemical response to decreased oxygen levels response to endogenous stimulus response to hypoxia response to nitrogen compound response to organic substance response to organonitrogen compound response to oxygen levels response to oxygen-containing compound response to peptide response to stimulus response to stress response to wounding scavenger receptor activity signal transduction signaling receptor activity sugar mediated signaling pathway system process transcytosis transmembrane signaling receptor activity transport across blood-brain barrier transport vascular process in circulatory system vascular transport vesicle-mediated transport	GO:0001540 GO:0001650 GO:0001666 GO:0001774 GO:0001775 GO:0001817 GO:0001818 GO:0001819 GO:0001910 GO:0001914 GO:0001932 GO:0001934 GO:0002269 GO:0002274 GO:0002376 GO:0002682 GO:0002684 GO:0002685 GO:0002687 GO:0002691 GO:0002693 GO:0002694 GO:0002696 GO:0002697 GO:0002703 GO:0002706 GO:0002709 GO:0002819 GO:0002822 GO:0003008 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0005044 GO:0005055 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005886 GO:0006355 GO:0006810 GO:0006950 GO:0006952 GO:0006954 GO:0007155 GO:0007165 GO:0007166 GO:0007610 GO:0007611 GO:0008104 GO:0008150 GO:0008284 GO:0009611 GO:0009628 GO:0009719 GO:0009756 GO:0009757 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009966 GO:0009967 GO:0009986 GO:0009987 GO:0010033 GO:0010182 GO:0010232 GO:0010243 GO:0010255 GO:0010468 GO:0010556 GO:0010557 GO:0010558 GO:0010562 GO:0010604 GO:0010605 GO:0010628 GO:0010629 GO:0010646 GO:0010647 GO:0010720 GO:0010950 GO:0010952 GO:0016020 GO:0016043 GO:0016192 GO:0016324 GO:0019219 GO:0019220 GO:0019222 GO:0022407 GO:0022409 GO:0023051 GO:0023056 GO:0030030 GO:0030054 GO:0030155 GO:0030162 GO:0030334 GO:0030335 GO:0031175 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031341 GO:0031347 GO:0031399 GO:0031401 GO:0032101 GO:0032103 GO:0032501 GO:0032642 GO:0032651 GO:0032652 GO:0032653 GO:0032655 GO:0032675 GO:0032680 GO:0032693 GO:0032722 GO:0032731 GO:0032732 GO:0032735 GO:0032755 GO:0032760 GO:0032872 GO:0032874 GO:0032944 GO:0032946 GO:0033036 GO:0033218 GO:0034103 GO:0034104 GO:0034114 GO:0034116 GO:0036293 GO:0038023 GO:0038024 GO:0040012 GO:0040017 GO:0042102 GO:0042104 GO:0042116 GO:0042127 GO:0042129 GO:0042221 GO:0042277 GO:0042325 GO:0042327 GO:0042802 GO:0043085 GO:0043408 GO:0043410 GO:0044057 GO:0044093 GO:0044548 GO:0044877 GO:0045056 GO:0045321 GO:0045595 GO:0045597 GO:0045785 GO:0045862 GO:0045937 GO:0046006 GO:0046328 GO:0046330 GO:0046634 GO:0048143 GO:0048167 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0050670 GO:0050671 GO:0050727 GO:0050776 GO:0050785 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050804 GO:0050806 GO:0050839 GO:0050863 GO:0050865 GO:0050867 GO:0050870 GO:0050877 GO:0050890 GO:0050896 GO:0050920 GO:0050921 GO:0050926 GO:0050927 GO:0050930 GO:0051090 GO:0051091 GO:0051092 GO:0051094 GO:0051171 GO:0051173 GO:0051174 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051246 GO:0051247 GO:0051249 GO:0051251 GO:0051252 GO:0051336 GO:0051345 GO:0051641 GO:0051668 GO:0051716 GO:0052547 GO:0052548 GO:0060089 GO:0060090 GO:0060255 GO:0060284 GO:0061900 GO:0065007 GO:0065008 GO:0065009 GO:0070302 GO:0070304 GO:0070372 GO:0070374 GO:0070482 GO:0070663 GO:0070665 GO:0070727 GO:0070887 GO:0071310 GO:0071417 GO:0071495 GO:0071637 GO:0071639 GO:0071675 GO:0071677 GO:0071840 GO:0072657 GO:0080090 GO:0080134 GO:0080135 GO:0098590 GO:0098631 GO:0098794 GO:0099177 GO:0110165 GO:0120036 GO:0150003 GO:0150104 GO:1900271 GO:1900272 GO:1900452 GO:1900453 GO:1900744 GO:1900745 GO:1901222 GO:1901224 GO:1901652 GO:1901653 GO:1901698 GO:1901699 GO:1901700 GO:1901701 GO:1902105 GO:1902107 GO:1902531 GO:1902533 GO:1902959 GO:1902961 GO:1902991 GO:1902993 GO:1903037 GO:1903039 GO:1903522 GO:1903523 GO:1903555 GO:1903557 GO:1903706 GO:1903708 GO:1904470 GO:1904472 GO:1904596 GO:1904597 GO:1904645 GO:1904646 GO:1905203 GO:1905204 GO:1905245 GO:1905247 GO:2000026 GO:2000145 GO:2000147 GO:2000437 GO:2000439 GO:2000514 GO:2001141 GO:2001198 GO:2001200
178	amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase	AGL Aliases: GDE glycogen debranching enzyme glycogen storage disease type III	Homo sapiens (human)	9606	Duchenne muscular dystrophy Laron syndrome achondroplasia acute promyelocytic leukemia atrichia with papular lesions autosomal dominant Emery-Dreifuss muscular dystrophy 2 autosomal dominant limb-girdle muscular dystrophy type 1 autosomal dominant limb-girdle muscular dystrophy type 1H autosomal dominant limb-girdle muscular dystrophy type 2 autosomal dominant limb-girdle muscular dystrophy type 3 autosomal dominant limb-girdle muscular dystrophy autosomal recessive limb-girdle muscular dystrophy type 2A autosomal recessive limb-girdle muscular dystrophy type 2B autosomal recessive limb-girdle muscular dystrophy type 2C autosomal recessive limb-girdle muscular dystrophy type 2D autosomal recessive limb-girdle muscular dystrophy type 2E autosomal recessive limb-girdle muscular dystrophy type 2F autosomal recessive limb-girdle muscular dystrophy type 2G autosomal recessive limb-girdle muscular dystrophy type 2H autosomal recessive limb-girdle muscular dystrophy type 2I autosomal recessive limb-girdle muscular dystrophy type 2J autosomal recessive limb-girdle muscular dystrophy type 2K autosomal recessive limb-girdle muscular dystrophy type 2L autosomal recessive limb-girdle muscular dystrophy type 2M autosomal recessive limb-girdle muscular dystrophy type 2N autosomal recessive limb-girdle muscular dystrophy type 2O autosomal recessive limb-girdle muscular dystrophy type 2P autosomal recessive limb-girdle muscular dystrophy type 2Q autosomal recessive limb-girdle muscular dystrophy type 2S autosomal recessive limb-girdle muscular dystrophy type 2T autosomal recessive limb-girdle muscular dystrophy type 2U autosomal recessive limb-girdle muscular dystrophy type 2Y autosomal recessive limb-girdle muscular dystrophy bladder carcinoma cancer cardiomyopathy colon cancer colon carcinoma colonic benign neoplasm colorectal cancer congenital generalized lipodystrophy type 1 congenital generalized lipodystrophy type 2 congenital generalized lipodystrophy type 3 congenital generalized lipodystrophy type 4 congenital muscular dystrophy cystinuria disease of metabolism distal myopathy endomyocardial fibrosis facioscapulohumeral muscular dystrophy familial hyperlipidemia familial partial lipodystrophy familial periodic paralysis galactosemia giardiasis glucosephosphate dehydrogenase deficiency glycogen storage disease II glycogen storage disease III glycogen storage disease IXa glycogen storage disease IXb glycogen storage disease IXc glycogen storage disease IXd glycogen storage disease Ia glycogen storage disease hepatitis C hypertrophic cardiomyopathy hypoglycemia isolated elevated serum creatine phosphokinase levels kidney failure large intestine cancer limb-girdle muscular dystrophy lipoatrophic diabetes mellitus lipodystrophy liver cirrhosis lung cancer lung non-small cell carcinoma muscular dystrophy myofibrillar myopathy 1 myofibrillar myopathy 3 myopathy nodular nonsuppurative panniculitis obsolete autosomal dominant limb-girdle muscular dystrophy type 1A obsolete autosomal dominant limb-girdle muscular dystrophy type 1B obsolete autosomal dominant limb-girdle muscular dystrophy type 1C obsolete autosomal recessive limb-girdle muscular dystrophy type 2R oculopharyngeal muscular dystrophy panniculitis primary immunodeficiency disease rippling muscle disease 2 uremia urinary bladder cancer	DOID:0014667 DOID:0050440 DOID:0050557 DOID:0050700 DOID:0060255 DOID:0060318 DOID:0060689 DOID:0070247 DOID:0080092 DOID:0080094 DOID:0110273 DOID:0110274 DOID:0110275 DOID:0110276 DOID:0110277 DOID:0110278 DOID:0110279 DOID:0110280 DOID:0110281 DOID:0110282 DOID:0110283 DOID:0110284 DOID:0110285 DOID:0110286 DOID:0110287 DOID:0110289 DOID:0110292 DOID:0110293 DOID:0110294 DOID:0110295 DOID:0110296 DOID:0110297 DOID:0110298 DOID:0110299 DOID:0110300 DOID:0110301 DOID:0110302 DOID:0110303 DOID:0110304 DOID:0110305 DOID:0110306 DOID:0111040 DOID:0111041 DOID:0111042 DOID:0111043 DOID:0111135 DOID:0111136 DOID:0111137 DOID:0111138 DOID:0111338 DOID:1029 DOID:10718 DOID:1074 DOID:11054 DOID:1168 DOID:11712 DOID:11719 DOID:11720 DOID:11723 DOID:11724 DOID:11727 DOID:11984 DOID:12932 DOID:1324 DOID:1520 DOID:1525 DOID:1526 DOID:162 DOID:1883 DOID:219 DOID:235 DOID:2747 DOID:2748 DOID:2749 DOID:2752 DOID:2862 DOID:3908 DOID:4007 DOID:423 DOID:4480 DOID:4676 DOID:5082 DOID:5672 DOID:612 DOID:811 DOID:9256 DOID:9266 DOID:9521 DOID:9870 DOID:9884 DOID:9993	4-alpha-glucanotransferase activity alpha-glucosidase activity amylo-alpha-1,6-glucosidase activity beta-maltose 4-alpha-glucanotransferase activity binding biological_process biosynthetic process carbohydrate binding carbohydrate biosynthetic process carbohydrate catabolic process carbohydrate metabolic process catabolic process catalytic activity catalytic complex cellular anatomical entity cellular biosynthetic process cellular metabolic process cellular process cellular_component cytoplasm cytoplasmic vesicle lumen cytosol endoplasmic reticulum energy derivation by oxidation of organic compounds energy reserve metabolic process extracellular region ficolin-1-rich granule lumen generation of precursor metabolites and energy glucan biosynthetic process glucan catabolic process glucan metabolic process glucosidase activity glycogen biosynthetic process glycogen catabolic process glycogen debranching enzyme activity glycogen metabolic process glycosyltransferase activity hexosyltransferase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity inclusion body intracellular anatomical structure intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle isoamylase complex macromolecule biosynthetic process macromolecule catabolic process macromolecule metabolic process membrane-bounded organelle membrane-enclosed lumen metabolic process modification-dependent protein binding molecular_function nucleus organelle lumen organelle organic substance biosynthetic process organic substance catabolic process organic substance metabolic process polysaccharide binding polysaccharide biosynthetic process polysaccharide catabolic process polysaccharide metabolic process polyubiquitin modification-dependent protein binding primary metabolic process protein binding protein-containing complex response to chemical response to corticosteroid response to endogenous stimulus response to external stimulus response to extracellular stimulus response to glucocorticoid response to hormone response to lipid response to nutrient levels response to nutrient response to organic cyclic compound response to organic substance response to steroid hormone response to stimulus sarcoplasmic reticulum secretory granule lumen transferase activity vesicle lumen	GO:0000271 GO:0000272 GO:0003674 GO:0003824 GO:0004133 GO:0004134 GO:0004135 GO:0004553 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005622 GO:0005634 GO:0005737 GO:0005783 GO:0005829 GO:0005975 GO:0005976 GO:0005977 GO:0005978 GO:0005980 GO:0006091 GO:0006112 GO:0007584 GO:0008150 GO:0008152 GO:0009056 GO:0009057 GO:0009058 GO:0009059 GO:0009250 GO:0009251 GO:0009605 GO:0009719 GO:0009725 GO:0009987 GO:0009991 GO:0010033 GO:0014070 GO:0015926 GO:0015980 GO:0016051 GO:0016052 GO:0016234 GO:0016529 GO:0016740 GO:0016757 GO:0016758 GO:0016787 GO:0016798 GO:0030246 GO:0030247 GO:0031593 GO:0031667 GO:0031960 GO:0031974 GO:0031983 GO:0032991 GO:0033993 GO:0034774 GO:0042221 GO:0043033 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0044042 GO:0044237 GO:0044238 GO:0044249 GO:0048545 GO:0050896 GO:0051384 GO:0060205 GO:0070013 GO:0071704 GO:0090599 GO:0102500 GO:0110165 GO:0140030 GO:1901575 GO:1901576 GO:1902494 GO:1904813
182	jagged canonical Notch ligand 1	JAG1	Homo sapiens (human)	9606			Notch binding Notch signaling pathway T cell mediated immunity adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains adaptive immune response adherens junction anatomical structure development anatomical structure formation involved in morphogenesis anatomical structure morphogenesis anchoring junction angiogenesis aorta morphogenesis aortic valve morphogenesis apical plasma membrane artery morphogenesis binding biological regulation biological_process blood vessel morphogenesis blood vessel remodeling calcium ion binding cardiac cell development cardiac chamber morphogenesis cardiac neural crest cell development involved in heart development cardiac neural crest cell development involved in outflow tract morphogenesis cardiac right ventricle morphogenesis cardiac septum morphogenesis cardiac ventricle morphogenesis cation binding cell development cell differentiation cell fate determination cell junction cell surface receptor signaling pathway cell-cell junction cellular anatomical entity cellular developmental process cellular process cellular_component ciliary body morphogenesis columnar/cuboidal epithelial cell differentiation developmental process distal tubule development endocardial cushion cell development endothelial cell differentiation epidermal cell differentiation epithelial cell development epithelial cell differentiation epithelium development extracellular region glomerular epithelial cell development growth factor activity hair cell differentiation heart valve morphogenesis hemopoiesis immune effector process immune response immune system process inhibition of neuroepithelial cell differentiation inner ear auditory receptor cell differentiation inner ear receptor cell differentiation ion binding keratinocyte differentiation kidney epithelium development leukocyte mediated immunity lipid binding loop of Henle development lymphocyte mediated immunity maintenance of cell number mechanoreceptor differentiation membrane metal ion binding molecular adaptor activity molecular function activator activity molecular function regulator activity molecular_function morphogenesis of an epithelial sheet morphogenesis of an epithelium multicellular organismal process myoblast differentiation negative regulation of biological process negative regulation of cell adhesion negative regulation of cell differentiation negative regulation of cell migration negative regulation of cell motility negative regulation of cell-cell adhesion negative regulation of cell-matrix adhesion negative regulation of cell-substrate adhesion negative regulation of cellular process negative regulation of developmental process negative regulation of endothelial cell differentiation negative regulation of epithelial cell differentiation negative regulation of fat cell differentiation negative regulation of locomotion negative regulation of neuron differentiation negative regulation of stem cell differentiation nephron development nephron epithelium development nephron tubule development nervous system development neural crest cell development neuroendocrine cell differentiation neuroepithelial cell differentiation neuron differentiation neuronal stem cell population maintenance phospholipid binding plasma membrane region plasma membrane podocyte development positive regulation of DNA-templated transcription positive regulation of Notch signaling pathway positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of cardiac epithelial to mesenchymal transition positive regulation of cell communication positive regulation of cell differentiation positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of developmental process positive regulation of epithelial to mesenchymal transition positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of myeloid cell differentiation positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of osteoblast differentiation positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of transcription by RNA polymerase II protein binding pulmonary artery morphogenesis pulmonary valve morphogenesis receptor ligand activity regulation of DNA-templated transcription regulation of Notch signaling pathway regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of anatomical structure morphogenesis regulation of biological process regulation of biosynthetic process regulation of cardiac epithelial to mesenchymal transition regulation of cell adhesion regulation of cell communication regulation of cell development regulation of cell differentiation regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cell-cell adhesion regulation of cell-matrix adhesion regulation of cell-substrate adhesion regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of development, heterochronic regulation of developmental process regulation of embryonic development regulation of endothelial cell differentiation regulation of epithelial cell differentiation regulation of epithelial cell proliferation regulation of epithelial to mesenchymal transition regulation of fat cell differentiation regulation of gene expression regulation of hemopoiesis regulation of immune system process regulation of locomotion regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal development regulation of multicellular organismal process regulation of myeloid cell differentiation regulation of neuron differentiation regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of osteoblast differentiation regulation of primary metabolic process regulation of reproductive process regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of stem cell differentiation regulation of timing of cell differentiation regulation of transcription by RNA polymerase II renal tubule development response to chemical response to muramyl dipeptide response to nitrogen compound response to organic substance response to organonitrogen compound response to oxygen-containing compound response to peptide response to stimulus signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity stem cell development stem cell population maintenance structural molecule activity system development tissue development tissue morphogenesis tissue remodeling tube development tube morphogenesis	GO:0001525 GO:0001709 GO:0001952 GO:0001953 GO:0001974 GO:0002009 GO:0002011 GO:0002064 GO:0002065 GO:0002085 GO:0002250 GO:0002252 GO:0002376 GO:0002443 GO:0002449 GO:0002456 GO:0002460 GO:0002682 GO:0003179 GO:0003180 GO:0003184 GO:0003206 GO:0003208 GO:0003215 GO:0003674 GO:0005102 GO:0005112 GO:0005198 GO:0005488 GO:0005509 GO:0005515 GO:0005543 GO:0005575 GO:0005576 GO:0005886 GO:0005911 GO:0005912 GO:0006355 GO:0006357 GO:0006955 GO:0007162 GO:0007165 GO:0007166 GO:0007219 GO:0007399 GO:0008083 GO:0008150 GO:0008289 GO:0008593 GO:0009653 GO:0009888 GO:0009889 GO:0009891 GO:0009893 GO:0009913 GO:0009966 GO:0009967 GO:0009987 GO:0010033 GO:0010243 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010646 GO:0010647 GO:0010717 GO:0010718 GO:0010810 GO:0010812 GO:0014032 GO:0016020 GO:0016324 GO:0019219 GO:0019222 GO:0019827 GO:0022407 GO:0022408 GO:0022603 GO:0023051 GO:0023056 GO:0030054 GO:0030097 GO:0030154 GO:0030155 GO:0030182 GO:0030216 GO:0030334 GO:0030336 GO:0030545 GO:0030546 GO:0030855 GO:0030856 GO:0030857 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0032495 GO:0032501 GO:0032502 GO:0035239 GO:0035295 GO:0035315 GO:0035909 GO:0040012 GO:0040013 GO:0040034 GO:0042127 GO:0042221 GO:0042490 GO:0042491 GO:0043167 GO:0043169 GO:0045445 GO:0045446 GO:0045595 GO:0045596 GO:0045597 GO:0045598 GO:0045599 GO:0045601 GO:0045602 GO:0045637 GO:0045639 GO:0045664 GO:0045665 GO:0045667 GO:0045669 GO:0045747 GO:0045893 GO:0045935 GO:0045944 GO:0045995 GO:0046872 GO:0048018 GO:0048468 GO:0048505 GO:0048514 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048646 GO:0048729 GO:0048731 GO:0048771 GO:0048844 GO:0048856 GO:0048864 GO:0048869 GO:0050678 GO:0050789 GO:0050793 GO:0050794 GO:0050896 GO:0051093 GO:0051094 GO:0051171 GO:0051173 GO:0051239 GO:0051240 GO:0051252 GO:0051254 GO:0055006 GO:0060090 GO:0060113 GO:0060255 GO:0060284 GO:0060411 GO:0060429 GO:0060563 GO:0061073 GO:0061101 GO:0061156 GO:0061308 GO:0061309 GO:0061326 GO:0061444 GO:0062042 GO:0062043 GO:0065007 GO:0070161 GO:0072006 GO:0072009 GO:0072015 GO:0072017 GO:0072070 GO:0072073 GO:0072080 GO:0072310 GO:0080090 GO:0097150 GO:0098590 GO:0098727 GO:0098772 GO:0110165 GO:0140677 GO:1901652 GO:1901698 GO:1901700 GO:1902680 GO:1903706 GO:2000026 GO:2000145 GO:2000146 GO:2000241 GO:2000736 GO:2000737 GO:2001141
183	angiotensinogen	AGT	Homo sapiens (human)	9606			G protein-coupled receptor binding G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein-coupled receptor signaling pathway anatomical structure development angiotensin receptor binding angiotensin-activated signaling pathway animal organ development binding biological regulation biological_process blood microparticle blood vessel diameter maintenance blood vessel remodeling cGMP-mediated signaling cell communication cell-cell signaling cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular process cellular_component channel regulator activity circulatory system process collagen-containing extracellular matrix cyclic-nucleotide-mediated signaling developmental process endocrine process endopeptidase inhibitor activity endopeptidase regulator activity enzyme activator activity enzyme inhibitor activity enzyme regulator activity external encapsulating structure extracellular exosome extracellular matrix extracellular membrane-bounded organelle extracellular organelle extracellular region extracellular space extracellular vesicle growth factor activity hormone activity intracellular signal transduction ion channel regulator activity kidney development low-density lipoprotein particle remodeling maintenance of blood vessel diameter homeostasis by renin-angiotensin membrane-bounded organelle molecular function activator activity molecular function inhibitor activity molecular function regulator activity molecular_function multicellular organismal process negative regulation of MAP kinase activity negative regulation of MAPK cascade negative regulation of biological process negative regulation of biosynthetic process negative regulation of catalytic activity negative regulation of cation transmembrane transport negative regulation of cell communication negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of cellular response to growth factor stimulus negative regulation of gene expression negative regulation of intracellular signal transduction negative regulation of kinase activity negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of molecular function negative regulation of monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of neurotrophin TRK receptor signaling pathway negative regulation of nitrogen compound metabolic process negative regulation of phosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of phosphorylation negative regulation of protein kinase activity negative regulation of protein metabolic process negative regulation of protein modification process negative regulation of protein phosphorylation negative regulation of protein serine/threonine kinase activity negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of sodium ion transmembrane transport negative regulation of sodium ion transport negative regulation of transferase activity negative regulation of transmembrane transport negative regulation of transport nitric oxide mediated signal transduction nitric oxide-cGMP-mediated signaling pathway organelle peptidase inhibitor activity peptidase regulator activity phospholipase C-activating G protein-coupled receptor signaling pathway plasma lipoprotein particle organization plasma lipoprotein particle remodeling positive regulation of CoA-transferase activity positive regulation of DNA-binding transcription factor activity positive regulation of DNA-templated transcription positive regulation of ERBB signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of activation of Janus kinase activity positive regulation of apoptotic process positive regulation of apoptotic signaling pathway positive regulation of biological process positive regulation of biosynthetic process positive regulation of branching involved in ureteric bud morphogenesis positive regulation of cardiac muscle hypertrophy positive regulation of catalytic activity positive regulation of cell communication positive regulation of cell differentiation positive regulation of cell junction assembly positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cellular biosynthetic process positive regulation of cellular component biogenesis positive regulation of cellular component organization positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of defense response positive regulation of developmental process positive regulation of endothelial cell migration positive regulation of epidermal growth factor receptor signaling pathway positive regulation of epithelial cell migration positive regulation of epithelial to mesenchymal transition positive regulation of extracellular matrix assembly positive regulation of extracellular matrix organization positive regulation of extrinsic apoptotic signaling pathway positive regulation of fibroblast proliferation positive regulation of gap junction assembly positive regulation of gene expression positive regulation of inflammatory response positive regulation of intracellular signal transduction positive regulation of kinase activity positive regulation of locomotion positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of macrophage derived foam cell differentiation positive regulation of membrane hyperpolarization positive regulation of metabolic process positive regulation of miRNA metabolic process positive regulation of miRNA transcription positive regulation of molecular function positive regulation of morphogenesis of an epithelium positive regulation of multicellular organismal process positive regulation of muscle hypertrophy positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphate metabolic process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of programmed cell death positive regulation of protein kinase activity positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of protein tyrosine kinase activity positive regulation of reactive oxygen species metabolic process positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of superoxide anion generation positive regulation of transferase activity protein binding protein-containing complex organization protein-containing complex remodeling protein-lipid complex organization protein-lipid complex remodeling receptor ligand activity regulation of CoA-transferase activity regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of ERBB signaling pathway regulation of MAP kinase activity regulation of MAPK cascade regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of activation of Janus kinase activity regulation of aldosterone secretion regulation of anatomical structure morphogenesis regulation of anatomical structure size regulation of animal organ morphogenesis regulation of apoptotic process regulation of apoptotic signaling pathway regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of blood circulation regulation of blood pressure regulation of blood volume by renin-angiotensin regulation of branching involved in ureteric bud morphogenesis regulation of cardiac conduction regulation of cardiac muscle hypertrophy regulation of catalytic activity regulation of cell communication regulation of cell differentiation regulation of cell growth regulation of cell junction assembly regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular component biogenesis regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cellular response to growth factor stimulus regulation of corticosteroid hormone secretion regulation of cytokine production regulation of defense response regulation of developmental process regulation of endocrine process regulation of endothelial cell migration regulation of epidermal growth factor receptor signaling pathway regulation of epithelial cell migration regulation of epithelial to mesenchymal transition regulation of excretion regulation of extracellular matrix assembly regulation of extracellular matrix organization regulation of extrinsic apoptotic signaling pathway regulation of fibroblast proliferation regulation of gap junction assembly regulation of gene expression regulation of growth regulation of heart contraction regulation of hormone levels regulation of hormone secretion regulation of inflammatory response regulation of intracellular signal transduction regulation of kidney development regulation of kinase activity regulation of lipid localization regulation of lipid transport regulation of localization regulation of locomotion regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of macrophage derived foam cell differentiation regulation of membrane hyperpolarization regulation of membrane potential regulation of metabolic process regulation of metal ion transport regulation of miRNA metabolic process regulation of miRNA transcription regulation of mineralocorticoid secretion regulation of molecular function regulation of monoatomic cation transmembrane transport regulation of monoatomic ion transmembrane transport regulation of monoatomic ion transport regulation of morphogenesis of a branching structure regulation of morphogenesis of an epithelium regulation of multicellular organismal process regulation of muscle adaptation regulation of muscle hypertrophy regulation of muscle system process regulation of ncRNA transcription regulation of neurotrophin TRK receptor signaling pathway regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of peptidyl-tyrosine phosphorylation regulation of phosphate metabolic process regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of phosphorus metabolic process regulation of phosphorylation regulation of primary metabolic process regulation of programmed cell death regulation of protein kinase activity regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of protein serine/threonine kinase activity regulation of protein tyrosine kinase activity regulation of reactive oxygen species metabolic process regulation of renal output by angiotensin regulation of renal sodium excretion regulation of renal system process regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling regulation of sodium ion transmembrane transport regulation of sodium ion transport regulation of steroid hormone secretion regulation of superoxide anion generation regulation of superoxide metabolic process regulation of system process regulation of systemic arterial blood pressure by hormone regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal regulation of systemic arterial blood pressure regulation of transferase activity regulation of transmembrane transport regulation of transport regulation of tube diameter regulation of tube size regulation of vasoconstriction renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure renal system process involved in regulation of systemic arterial blood pressure renal system process renin-angiotensin regulation of aldosterone production response to activity response to angiotensin response to chemical response to endogenous stimulus response to hormone response to muscle activity involved in regulation of muscle adaptation response to muscle activity response to nitrogen compound response to organic substance response to organonitrogen compound response to oxygen-containing compound response to peptide hormone response to peptide response to stimulus involved in regulation of muscle adaptation response to stimulus second-messenger-mediated signaling serine-type endopeptidase inhibitor activity signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity signaling sodium channel regulator activity superoxide-generating NADPH oxidase activator activity system process tissue remodeling transporter regulator activity type 1 angiotensin receptor binding type 2 angiotensin receptor binding vascular process in circulatory system vasoconstriction vesicle	GO:0001558 GO:0001664 GO:0001817 GO:0001819 GO:0001822 GO:0001932 GO:0001933 GO:0001934 GO:0001974 GO:0001990 GO:0002016 GO:0002018 GO:0002019 GO:0002028 GO:0002034 GO:0003008 GO:0003013 GO:0003014 GO:0003018 GO:0003044 GO:0003071 GO:0003072 GO:0003073 GO:0003081 GO:0003674 GO:0004857 GO:0004866 GO:0004867 GO:0005102 GO:0005179 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0006355 GO:0006469 GO:0007154 GO:0007165 GO:0007186 GO:0007187 GO:0007199 GO:0007200 GO:0007263 GO:0007267 GO:0008016 GO:0008047 GO:0008083 GO:0008150 GO:0008217 GO:0008284 GO:0009719 GO:0009725 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010033 GO:0010243 GO:0010468 GO:0010533 GO:0010536 GO:0010556 GO:0010557 GO:0010558 GO:0010562 GO:0010563 GO:0010594 GO:0010595 GO:0010604 GO:0010605 GO:0010611 GO:0010613 GO:0010628 GO:0010629 GO:0010632 GO:0010634 GO:0010646 GO:0010647 GO:0010648 GO:0010717 GO:0010718 GO:0010743 GO:0010744 GO:0010766 GO:0010817 GO:0010959 GO:0014742 GO:0014743 GO:0014823 GO:0014850 GO:0014873 GO:0014874 GO:0016043 GO:0016176 GO:0016247 GO:0017080 GO:0019219 GO:0019220 GO:0019222 GO:0019229 GO:0019932 GO:0019934 GO:0019935 GO:0022603 GO:0023051 GO:0023052 GO:0023056 GO:0023057 GO:0030234 GO:0030312 GO:0030334 GO:0030335 GO:0030414 GO:0030545 GO:0030546 GO:0031012 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031347 GO:0031349 GO:0031399 GO:0031400 GO:0031401 GO:0031701 GO:0031702 GO:0031703 GO:0031982 GO:0032101 GO:0032103 GO:0032368 GO:0032501 GO:0032502 GO:0032879 GO:0032928 GO:0032930 GO:0033673 GO:0033674 GO:0034367 GO:0034368 GO:0034369 GO:0034374 GO:0034762 GO:0034763 GO:0034765 GO:0034766 GO:0035150 GO:0035296 GO:0035556 GO:0035813 GO:0038060 GO:0038166 GO:0040008 GO:0040012 GO:0040017 GO:0042058 GO:0042127 GO:0042221 GO:0042310 GO:0042325 GO:0042326 GO:0042327 GO:0042391 GO:0042981 GO:0043065 GO:0043067 GO:0043068 GO:0043085 GO:0043086 GO:0043226 GO:0043227 GO:0043230 GO:0043269 GO:0043271 GO:0043405 GO:0043407 GO:0043408 GO:0043409 GO:0043434 GO:0043502 GO:0043549 GO:0043933 GO:0044057 GO:0044060 GO:0044062 GO:0044087 GO:0044089 GO:0044092 GO:0044093 GO:0045595 GO:0045597 GO:0045742 GO:0045859 GO:0045860 GO:0045893 GO:0045935 GO:0045936 GO:0045937 GO:0046883 GO:0048018 GO:0048145 GO:0048146 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048771 GO:0048856 GO:0050727 GO:0050729 GO:0050730 GO:0050731 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050886 GO:0050896 GO:0051046 GO:0051049 GO:0051051 GO:0051090 GO:0051091 GO:0051092 GO:0051094 GO:0051128 GO:0051130 GO:0051171 GO:0051172 GO:0051173 GO:0051174 GO:0051239 GO:0051240 GO:0051246 GO:0051247 GO:0051248 GO:0051252 GO:0051254 GO:0051338 GO:0051347 GO:0051348 GO:0051386 GO:0051387 GO:0051896 GO:0051897 GO:0060255 GO:0060688 GO:0061097 GO:0061098 GO:0061134 GO:0061135 GO:0062023 GO:0065007 GO:0065008 GO:0065009 GO:0065010 GO:0070062 GO:0071825 GO:0071827 GO:0071840 GO:0071900 GO:0071901 GO:0072562 GO:0080090 GO:0080134 GO:0090066 GO:0090183 GO:0090189 GO:0090190 GO:0090257 GO:0090287 GO:0090288 GO:0090322 GO:0097746 GO:0098772 GO:0098801 GO:0099106 GO:0110165 GO:0140677 GO:0140678 GO:0140747 GO:0141108 GO:1901184 GO:1901186 GO:1901201 GO:1901203 GO:1901652 GO:1901698 GO:1901700 GO:1901888 GO:1901890 GO:1902305 GO:1902306 GO:1902531 GO:1902532 GO:1902533 GO:1902630 GO:1902632 GO:1902680 GO:1902893 GO:1902895 GO:1903053 GO:1903055 GO:1903522 GO:1903530 GO:1903561 GO:1903596 GO:1903598 GO:1903779 GO:1904062 GO:1904063 GO:1905330 GO:1905332 GO:1905918 GO:1905920 GO:1905952 GO:1990776 GO:2000027 GO:2000145 GO:2000147 GO:2000377 GO:2000379 GO:2000628 GO:2000630 GO:2000831 GO:2000846 GO:2000855 GO:2000858 GO:2001141 GO:2001233 GO:2001235 GO:2001236 GO:2001238
185	angiotensin II receptor type 1	AGTR1	Homo sapiens (human)	9606			G protein-coupled peptide receptor activity G protein-coupled receptor activity G protein-coupled receptor binding G protein-coupled receptor signaling pathway Ras protein signal transduction Rho protein signal transduction anatomical structure development angiotensin receptor activity angiotensin type I receptor activity angiotensin type II receptor activity angiotensin-activated signaling pathway animal organ development binding biological process involved in interaction with host biological process involved in interspecies interaction between organisms biological process involved in symbiotic interaction biological regulation biological_process blood vessel diameter maintenance bradykinin receptor binding calcium-mediated signaling cell chemotaxis cell migration cell motility cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular process cellular_component chemotaxis circulatory system process defense response developmental process endocrine process entry into host inflammatory response intracellular signal transduction kidney development locomotion low-density lipoprotein particle remodeling maintenance of blood vessel diameter homeostasis by renin-angiotensin membrane molecular transducer activity molecular_function movement in host multicellular organismal process peptide receptor activity phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating angiotensin-activated signaling pathway plasma lipoprotein particle organization plasma lipoprotein particle remodeling plasma membrane positive regulation of CoA-transferase activity positive regulation of biological process positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of catalytic activity positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytosolic calcium ion concentration positive regulation of defense response positive regulation of developmental process positive regulation of endothelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of hydrolase activity positive regulation of inflammatory response positive regulation of lipase activity positive regulation of macromolecule metabolic process positive regulation of macrophage derived foam cell differentiation positive regulation of metabolic process positive regulation of molecular function positive regulation of nitrogen compound metabolic process positive regulation of phospholipase A2 activity positive regulation of phospholipase activity positive regulation of protein metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of transferase activity protein binding protein dimerization activity protein heterodimerization activity protein-containing complex organization protein-containing complex remodeling protein-lipid complex organization protein-lipid complex remodeling regulation of CoA-transferase activity regulation of aldosterone secretion regulation of anatomical structure size regulation of biological process regulation of biological quality regulation of blood circulation regulation of blood pressure regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of catalytic activity regulation of cell communication regulation of cell differentiation regulation of cell growth regulation of cell population proliferation regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of corticosteroid hormone secretion regulation of defense response regulation of developmental process regulation of endocrine process regulation of endothelial cell proliferation regulation of epithelial cell proliferation regulation of excretion regulation of growth regulation of hormone levels regulation of hormone secretion regulation of hydrolase activity regulation of inflammatory response regulation of lipase activity regulation of lipid localization regulation of lipid transport regulation of localization regulation of macromolecule metabolic process regulation of macrophage derived foam cell differentiation regulation of metabolic process regulation of mineralocorticoid secretion regulation of molecular function regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of phospholipase A2 activity regulation of phospholipase activity regulation of primary metabolic process regulation of protein metabolic process regulation of reactive oxygen species metabolic process regulation of renal sodium excretion regulation of renal system process regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of secretion by cell regulation of secretion regulation of signaling regulation of steroid hormone secretion regulation of system process regulation of systemic arterial blood pressure by hormone regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal regulation of systemic arterial blood pressure regulation of transferase activity regulation of transport regulation of tube diameter regulation of tube size regulation of vasoconstriction renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure renal system process involved in regulation of systemic arterial blood pressure renal system process renin-angiotensin regulation of aldosterone production response to stimulus response to stress second-messenger-mediated signaling signal transduction signaling receptor activity signaling receptor binding small GTPase mediated signal transduction system process taxis transmembrane signaling receptor activity vascular process in circulatory system viral entry into host cell	GO:0001558 GO:0001595 GO:0001596 GO:0001653 GO:0001664 GO:0001822 GO:0001936 GO:0001938 GO:0001990 GO:0002018 GO:0002034 GO:0003008 GO:0003013 GO:0003014 GO:0003018 GO:0003044 GO:0003071 GO:0003072 GO:0003073 GO:0003081 GO:0003674 GO:0004888 GO:0004930 GO:0004945 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0006935 GO:0006950 GO:0006952 GO:0006954 GO:0007165 GO:0007186 GO:0007200 GO:0007204 GO:0007264 GO:0007265 GO:0007266 GO:0008150 GO:0008217 GO:0008284 GO:0008528 GO:0009893 GO:0009987 GO:0010517 GO:0010518 GO:0010604 GO:0010646 GO:0010743 GO:0010744 GO:0010817 GO:0016020 GO:0016043 GO:0016477 GO:0019222 GO:0019229 GO:0019722 GO:0019932 GO:0023051 GO:0031323 GO:0031325 GO:0031347 GO:0031349 GO:0031711 GO:0032101 GO:0032103 GO:0032368 GO:0032429 GO:0032430 GO:0032501 GO:0032502 GO:0032879 GO:0034367 GO:0034368 GO:0034369 GO:0034374 GO:0035150 GO:0035296 GO:0035556 GO:0035813 GO:0038023 GO:0038166 GO:0040008 GO:0040011 GO:0042127 GO:0042330 GO:0043085 GO:0043933 GO:0044000 GO:0044057 GO:0044060 GO:0044062 GO:0044093 GO:0044403 GO:0044409 GO:0044419 GO:0045595 GO:0045597 GO:0046718 GO:0046883 GO:0046982 GO:0046983 GO:0048513 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0048856 GO:0048870 GO:0050678 GO:0050679 GO:0050727 GO:0050729 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050886 GO:0050896 GO:0051046 GO:0051049 GO:0051094 GO:0051128 GO:0051171 GO:0051173 GO:0051239 GO:0051246 GO:0051247 GO:0051336 GO:0051338 GO:0051345 GO:0051347 GO:0051701 GO:0060089 GO:0060191 GO:0060193 GO:0060255 GO:0060326 GO:0065007 GO:0065008 GO:0065009 GO:0071825 GO:0071827 GO:0071840 GO:0080090 GO:0080134 GO:0086097 GO:0090066 GO:0097746 GO:0098801 GO:0110165 GO:1903522 GO:1903530 GO:1903587 GO:1903589 GO:1905918 GO:1905920 GO:1905952 GO:2000377 GO:2000379 GO:2000831 GO:2000846 GO:2000855 GO:2000858
186	angiotensin II receptor type 2	AGTR2	Homo sapiens (human)	9606			G protein-coupled peptide receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein-coupled receptor signaling pathway anatomical structure development angiotensin receptor activity angiotensin type II receptor activity angiotensin-activated signaling pathway angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure animal organ development apoptotic process behavior binding biological regulation biological_process blood vessel diameter maintenance blood vessel remodeling brain development brain renin-angiotensin system cGMP-mediated signaling cell death cell surface receptor signaling pathway cellular anatomical entity cellular process cellular_component circulatory system process cyclic-nucleotide-mediated signaling defense response developmental process endocrine process exploration behavior inflammatory response intracellular signal transduction kidney development membrane metanephros development molecular function inhibitor activity molecular function regulator activity molecular transducer activity molecular_function multicellular organismal process negative regulation of biological process negative regulation of blood circulation negative regulation of blood pressure negative regulation of blood vessel endothelial cell migration negative regulation of cell communication negative regulation of cell growth negative regulation of cell migration negative regulation of cell motility negative regulation of cellular process negative regulation of cellular response to growth factor stimulus negative regulation of endothelial cell migration negative regulation of epithelial cell migration negative regulation of growth negative regulation of heart contraction negative regulation of heart rate negative regulation of locomotion negative regulation of multicellular organismal process negative regulation of neurotrophin TRK receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of systemic arterial blood pressure nervous system process involved in regulation of systemic arterial blood pressure nervous system process neuron apoptotic process nitric oxide mediated signal transduction nitric oxide-cGMP-mediated signaling pathway peptide receptor activity plasma membrane positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of apoptotic process positive regulation of apoptotic signaling pathway positive regulation of biological process positive regulation of biosynthetic process positive regulation of branching involved in ureteric bud morphogenesis positive regulation of catalytic activity positive regulation of cell communication positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of dephosphorylation positive regulation of developmental process positive regulation of extrinsic apoptotic signaling pathway positive regulation of glomerulus development positive regulation of hydrolase activity positive regulation of kidney development positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of metanephric glomerulus development positive regulation of metanephros development positive regulation of molecular function positive regulation of morphogenesis of an epithelium positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of phosphatase activity positive regulation of phosphate metabolic process positive regulation of phosphoprotein phosphatase activity positive regulation of phosphorus metabolic process positive regulation of programmed cell death positive regulation of protein dephosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling programmed cell death protein binding receptor antagonist activity regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of anatomical structure morphogenesis regulation of anatomical structure size regulation of animal organ morphogenesis regulation of apoptotic process regulation of apoptotic signaling pathway regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of blood circulation regulation of blood pressure regulation of blood vessel endothelial cell migration regulation of blood volume by renin-angiotensin regulation of branching involved in ureteric bud morphogenesis regulation of catalytic activity regulation of cell communication regulation of cell growth regulation of cell migration regulation of cell motility regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cellular response to growth factor stimulus regulation of dephosphorylation regulation of developmental process regulation of endothelial cell migration regulation of epithelial cell migration regulation of extrinsic apoptotic signaling pathway regulation of gene expression regulation of glomerulus development regulation of growth regulation of heart contraction regulation of heart rate regulation of hydrolase activity regulation of kidney development regulation of kidney size regulation of locomotion regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of metanephric glomerulus development regulation of metanephros development regulation of metanephros size regulation of molecular function regulation of morphogenesis of a branching structure regulation of morphogenesis of an epithelium regulation of multicellular organismal process regulation of neurotrophin TRK receptor signaling pathway regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of phosphatase activity regulation of phosphate metabolic process regulation of phosphoprotein phosphatase activity regulation of phosphorus metabolic process regulation of primary metabolic process regulation of programmed cell death regulation of protein dephosphorylation regulation of protein metabolic process regulation of protein modification process regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of system process regulation of systemic arterial blood pressure by circulatory renin-angiotensin regulation of systemic arterial blood pressure by hormone regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal regulation of systemic arterial blood pressure regulation of tube diameter regulation of tube size response to stimulus response to stress second-messenger-mediated signaling signal transduction signaling receptor activity signaling receptor binding signaling receptor inhibitor activity signaling receptor regulator activity system process tissue remodeling transmembrane signaling receptor activity vascular process in circulatory system vasodilation	GO:0001558 GO:0001595 GO:0001653 GO:0001656 GO:0001822 GO:0001974 GO:0001976 GO:0001990 GO:0001991 GO:0002016 GO:0002027 GO:0002033 GO:0002035 GO:0003008 GO:0003013 GO:0003018 GO:0003044 GO:0003073 GO:0003081 GO:0003085 GO:0003674 GO:0004888 GO:0004930 GO:0004945 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0006355 GO:0006915 GO:0006950 GO:0006952 GO:0006954 GO:0007165 GO:0007166 GO:0007186 GO:0007187 GO:0007199 GO:0007263 GO:0007420 GO:0007610 GO:0008016 GO:0008150 GO:0008217 GO:0008219 GO:0008528 GO:0009889 GO:0009891 GO:0009893 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010459 GO:0010468 GO:0010556 GO:0010557 GO:0010562 GO:0010594 GO:0010596 GO:0010604 GO:0010632 GO:0010633 GO:0010646 GO:0010647 GO:0010648 GO:0010921 GO:0010922 GO:0012501 GO:0016020 GO:0019219 GO:0019220 GO:0019222 GO:0019932 GO:0019934 GO:0019935 GO:0022603 GO:0023051 GO:0023056 GO:0023057 GO:0030308 GO:0030334 GO:0030336 GO:0030545 GO:0030547 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031399 GO:0031401 GO:0032501 GO:0032502 GO:0032516 GO:0035150 GO:0035296 GO:0035303 GO:0035304 GO:0035306 GO:0035307 GO:0035556 GO:0035564 GO:0035566 GO:0035640 GO:0038023 GO:0038060 GO:0038166 GO:0040008 GO:0040012 GO:0040013 GO:0042311 GO:0042981 GO:0043065 GO:0043067 GO:0043068 GO:0043085 GO:0043535 GO:0043537 GO:0043666 GO:0044057 GO:0044093 GO:0045776 GO:0045822 GO:0045893 GO:0045926 GO:0045935 GO:0045937 GO:0048019 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048771 GO:0048856 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050877 GO:0050886 GO:0050896 GO:0051094 GO:0051128 GO:0051171 GO:0051173 GO:0051174 GO:0051239 GO:0051240 GO:0051241 GO:0051246 GO:0051247 GO:0051252 GO:0051254 GO:0051336 GO:0051345 GO:0051386 GO:0051387 GO:0051402 GO:0060089 GO:0060255 GO:0060688 GO:0065007 GO:0065008 GO:0065009 GO:0072215 GO:0072216 GO:0072298 GO:0072300 GO:0080090 GO:0090066 GO:0090183 GO:0090184 GO:0090189 GO:0090190 GO:0090192 GO:0090193 GO:0090287 GO:0090288 GO:0097746 GO:0098772 GO:0110165 GO:0140678 GO:1902680 GO:1903522 GO:1903523 GO:1905330 GO:1905332 GO:2000027 GO:2000145 GO:2000146 GO:2001141 GO:2001233 GO:2001235 GO:2001236 GO:2001238
187	apelin receptor	APLNR	Homo sapiens (human)	9606			G protein-coupled peptide receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway adult heart development anatomical structure development anatomical structure formation involved in morphogenesis anatomical structure morphogenesis angiogenesis animal organ development aorta development apelin receptor activity apelin receptor signaling pathway artery development atrioventricular valve development binding biological regulation biological_process blood vessel development cardiac septum morphogenesis cell differentiation cellular anatomical entity cellular developmental process cellular process cellular_component coronary vasculature development developmental process embryonic heart tube morphogenesis embryonic morphogenesis endocardial cushion formation epithelial tube morphogenesis gastrulation heart development heart looping heart valve development membrane molecular transducer activity molecular_function morphogenesis of an epithelium muscle cell differentiation negative regulation of biological process negative regulation of biosynthetic process negative regulation of cAMP-mediated signaling negative regulation of cell communication negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of gene expression negative regulation of intracellular signal transduction negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling peptide receptor activity plasma membrane positive regulation of G protein-coupled receptor internalization positive regulation of angiogenesis positive regulation of biological process positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of calcium ion transmembrane transport positive regulation of calcium ion transport positive regulation of cation transmembrane transport positive regulation of cell population proliferation positive regulation of cellular component organization positive regulation of cellular process positive regulation of developmental process positive regulation of endocytosis positive regulation of endothelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of monoatomic ion transmembrane transport positive regulation of monoatomic ion transport positive regulation of multicellular organismal process positive regulation of receptor internalization positive regulation of receptor-mediated endocytosis positive regulation of release of sequestered calcium ion into cytosol positive regulation of transmembrane transport positive regulation of transport positive regulation of vasculature development protein binding regulation of G protein-coupled receptor internalization regulation of G protein-coupled receptor signaling pathway regulation of anatomical structure morphogenesis regulation of angiogenesis regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of body fluid levels regulation of cAMP-mediated signaling regulation of calcium ion transmembrane transport regulation of calcium ion transport regulation of cell communication regulation of cell junction assembly regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular component biogenesis regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of developmental process regulation of endocytosis regulation of endothelial cell proliferation regulation of epithelial cell proliferation regulation of gap junction assembly regulation of gene expression regulation of intracellular signal transduction regulation of localization regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of metal ion transport regulation of monoatomic cation transmembrane transport regulation of monoatomic ion transmembrane transport regulation of monoatomic ion transport regulation of multicellular organismal development regulation of multicellular organismal process regulation of receptor internalization regulation of receptor-mediated endocytosis regulation of release of sequestered calcium ion into cytosol regulation of response to stimulus regulation of sequestering of calcium ion regulation of signal transduction regulation of signaling regulation of transmembrane transport regulation of transport regulation of vasculature development regulation of vesicle-mediated transport signal transduction signaling receptor activity smooth muscle cell differentiation system development tissue morphogenesis transmembrane signaling receptor activity tube morphogenesis vascular associated smooth muscle cell differentiation vasculature development vasculogenesis venous blood vessel development ventricular septum morphogenesis	GO:0001525 GO:0001568 GO:0001570 GO:0001653 GO:0001936 GO:0001938 GO:0001944 GO:0001947 GO:0002009 GO:0002090 GO:0002092 GO:0003143 GO:0003170 GO:0003171 GO:0003272 GO:0003674 GO:0004888 GO:0004930 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0007165 GO:0007186 GO:0007369 GO:0007507 GO:0007512 GO:0008150 GO:0008277 GO:0008284 GO:0008528 GO:0009653 GO:0009889 GO:0009890 GO:0009892 GO:0009966 GO:0009968 GO:0009987 GO:0010468 GO:0010556 GO:0010558 GO:0010605 GO:0010629 GO:0010646 GO:0010648 GO:0010959 GO:0016020 GO:0019222 GO:0022603 GO:0023051 GO:0023057 GO:0030100 GO:0030154 GO:0031323 GO:0031324 GO:0031326 GO:0031327 GO:0032502 GO:0032879 GO:0034762 GO:0034764 GO:0034765 GO:0034767 GO:0035239 GO:0035886 GO:0035904 GO:0038023 GO:0042127 GO:0042692 GO:0043269 GO:0043270 GO:0043949 GO:0043951 GO:0044087 GO:0045765 GO:0045766 GO:0045807 GO:0048259 GO:0048260 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048585 GO:0048598 GO:0048646 GO:0048729 GO:0048731 GO:0048856 GO:0048869 GO:0050678 GO:0050679 GO:0050789 GO:0050793 GO:0050794 GO:0050878 GO:0051049 GO:0051050 GO:0051094 GO:0051128 GO:0051130 GO:0051145 GO:0051239 GO:0051240 GO:0051279 GO:0051281 GO:0051282 GO:0051924 GO:0051928 GO:0060089 GO:0060182 GO:0060183 GO:0060255 GO:0060411 GO:0060412 GO:0060562 GO:0060627 GO:0060840 GO:0060841 GO:0060976 GO:0065007 GO:0065008 GO:0110165 GO:1901342 GO:1901888 GO:1902531 GO:1902532 GO:1903169 GO:1903587 GO:1903589 GO:1903596 GO:1904018 GO:1904020 GO:1904022 GO:1904062 GO:1904064 GO:1904427 GO:2000026
189	alanine--glyoxylate aminotransferase	AGXT Aliases: AGT AGT1 AGXT1 L-alanine: glyoxylate aminotransferase 1 PH1 SPT Ser-PyrAT TLH6 glycolicaciduria oxalosis I primary hyperoxaluria type 1	Homo sapiens (human)	9606	Foster-Kennedy syndrome Laurin-Sandrow syndrome Raynaud disease Senior-Loken syndrome acrodermatitis allergic asthma allergic rhinitis alopecia androgenic alopecia anemia angioedema arteriolosclerosis arteriosclerosis arteriosclerotic cardiovascular disease asthma atherosclerosis atrioventricular block autosomal recessive osteopetrosis 7 beriberi calcinosis calcium metabolism disease cancer carcinoma cerebral infarction cerebrovascular disease chronic kidney disease coronary artery disease cystinuria dermatitis disease of metabolism distal arthrogryposis eosinophilic esophagitis essential hypertension extraosseous Ewing sarcoma extraosseous Ewings sarcoma-primitive neuroepithelial tumor galactosemia giant cell glioblastoma glioblastoma glucosephosphate dehydrogenase deficiency glycogen storage disease Ia glycogen storage disease hepatocellular carcinoma hereditary sensory and autonomic neuropathy type 1 hereditary sensory and autonomic neuropathy type 1A hereditary sensory neuropathy high grade glioma hypercalcemia hypertension inherited metabolic disorder intermittent claudication intrinsic asthma kidney failure lactic acidosis liver cancer macrocytic anemia middle cerebral artery infarction nephrocalcinosis nephrolithiasis nephronophthisis neuropathy optic atrophy optic nerve disease osteopetrosis osteosclerosis parasitic helminthiasis infectious disease peripheral nervous system disease peripheral vascular disease phosphorus metabolism disease primary hyperoxaluria type 1 primary hyperoxaluria retinal disease retinitis riboflavin deficiency sarcomatoid carcinoma sensory peripheral neuropathy skin disease subacute bacterial endocarditis thiamine deficiency disease uremia uric acid nephrolithiasis urinary tract obstruction urticaria vasomotor rhinitis visual pathway disease	DOID:0014667 DOID:0050548 DOID:0050576 DOID:0050646 DOID:0050801 DOID:0050820 DOID:0070152 DOID:0070162 DOID:0070313 DOID:0110946 DOID:0111350 DOID:0111670 DOID:10300 DOID:10575 DOID:1074 DOID:10763 DOID:10825 DOID:12678 DOID:12679 DOID:12712 DOID:13533 DOID:13725 DOID:13922 DOID:1393 DOID:14555 DOID:1555 DOID:1558 DOID:162 DOID:182 DOID:1891 DOID:1936 DOID:2348 DOID:2349 DOID:2355 DOID:2361 DOID:2485 DOID:2491 DOID:2722 DOID:2723 DOID:2747 DOID:2749 DOID:2841 DOID:2862 DOID:2977 DOID:305 DOID:3068 DOID:3070 DOID:3074 DOID:3393 DOID:341 DOID:3525 DOID:3526 DOID:3571 DOID:3612 DOID:3650 DOID:3669 DOID:37 DOID:4015 DOID:4232 DOID:4254 DOID:4481 DOID:4562 DOID:4676 DOID:4730 DOID:4985 DOID:5162 DOID:5200 DOID:5679 DOID:5723 DOID:574 DOID:580 DOID:585 DOID:655 DOID:6713 DOID:684 DOID:784 DOID:8454 DOID:870 DOID:883 DOID:9266 DOID:9360 DOID:9415 DOID:987 DOID:9870	L-alanine catabolic process L-alanine metabolic process L-cysteine catabolic process L-cysteine metabolic process L-serine metabolic process Notch signaling pathway acid secretion alanine catabolic process alanine metabolic process alanine-glyoxylate transaminase activity aldehyde catabolic process alpha-amino acid biosynthetic process alpha-amino acid catabolic process alpha-amino acid metabolic process amino acid binding amino acid biosynthetic process amino acid catabolic process amino acid metabolic process anion binding binding biological regulation biological_process biosynthetic process carboxylic acid binding carboxylic acid biosynthetic process carboxylic acid catabolic process carboxylic acid metabolic process carboxylic acid transport catabolic process catalytic activity cell surface receptor signaling pathway cellular aldehyde metabolic process cellular anatomical entity cellular biosynthetic process cellular catabolic process cellular metabolic process cellular modified amino acid catabolic process cellular modified amino acid metabolic process cellular process cellular_component cysteine catabolic process cysteine metabolic process cytosol dicarboxylic acid transport establishment of localization glycine biosynthetic process, by transamination of glyoxylate glycine biosynthetic process glycine metabolic process glyoxylate catabolic process glyoxylate metabolic process heterocyclic compound binding identical protein binding intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle ion binding localization membrane-bounded organelle membrane-enclosed lumen metabolic process microbody lumen microbody molecular_function monocarboxylic acid catabolic process monocarboxylic acid metabolic process nitrogen compound metabolic process nitrogen compound transport organelle lumen organelle organic acid binding organic acid biosynthetic process organic acid catabolic process organic acid metabolic process organic acid transport organic anion transport organic cyclic compound binding organic substance biosynthetic process organic substance catabolic process organic substance metabolic process organic substance transport organonitrogen compound biosynthetic process organonitrogen compound catabolic process organonitrogen compound metabolic process oxalate transport oxalic acid secretion oxoacid metabolic process peroxisomal matrix peroxisome primary metabolic process protein binding protein dimerization activity protein homodimerization activity pyridoxal phosphate binding pyruvate family amino acid catabolic process pyruvate family amino acid metabolic process regulation of biological process regulation of cellular process secretion serine family amino acid biosynthetic process serine family amino acid catabolic process serine family amino acid metabolic process serine-pyruvate transaminase activity signal transduction small molecule binding small molecule biosynthetic process small molecule catabolic process small molecule metabolic process sulfur amino acid catabolic process sulfur amino acid metabolic process sulfur compound catabolic process sulfur compound metabolic process transaminase activity transferase activity, transferring nitrogenous groups transferase activity transport vitamin B6 binding vitamin binding	GO:0000096 GO:0000098 GO:0003674 GO:0003824 GO:0004760 GO:0005488 GO:0005515 GO:0005575 GO:0005777 GO:0005782 GO:0005829 GO:0006081 GO:0006082 GO:0006520 GO:0006522 GO:0006524 GO:0006534 GO:0006544 GO:0006545 GO:0006563 GO:0006575 GO:0006790 GO:0006807 GO:0006810 GO:0006835 GO:0007165 GO:0007166 GO:0007219 GO:0008150 GO:0008152 GO:0008453 GO:0008483 GO:0008652 GO:0009056 GO:0009058 GO:0009063 GO:0009069 GO:0009070 GO:0009071 GO:0009078 GO:0009080 GO:0009093 GO:0009436 GO:0009987 GO:0015711 GO:0015849 GO:0016053 GO:0016054 GO:0016597 GO:0016740 GO:0016769 GO:0019265 GO:0019448 GO:0019532 GO:0019752 GO:0019842 GO:0030170 GO:0031406 GO:0031907 GO:0031974 GO:0032787 GO:0036094 GO:0042219 GO:0042579 GO:0042802 GO:0042803 GO:0042851 GO:0042853 GO:0043167 GO:0043168 GO:0043177 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0043436 GO:0044237 GO:0044238 GO:0044248 GO:0044249 GO:0044273 GO:0044281 GO:0044282 GO:0044283 GO:0046185 GO:0046394 GO:0046395 GO:0046439 GO:0046487 GO:0046717 GO:0046724 GO:0046903 GO:0046942 GO:0046983 GO:0050789 GO:0050794 GO:0051179 GO:0051234 GO:0065007 GO:0070013 GO:0070279 GO:0071702 GO:0071704 GO:0071705 GO:0072329 GO:0097159 GO:0110165 GO:1901363 GO:1901564 GO:1901565 GO:1901566 GO:1901575 GO:1901576 GO:1901605 GO:1901606 GO:1901607
190	nuclear receptor subfamily 0 group B member 1	NR0B1	Homo sapiens (human)	9606			AF-2 domain binding DNA binding DNA hairpin binding DNA secondary structure binding DNA-binding transcription factor binding Leydig cell differentiation RNA binding RNA polymerase II-specific DNA-binding transcription factor binding Sertoli cell differentiation adrenal gland development anatomical structure development animal organ development binding biological regulation biological_process cell differentiation cellular anatomical entity cellular developmental process cellular localization cellular macromolecule localization cellular process cellular_component centriolar satellite chromatin cytoplasm developmental process involved in reproduction developmental process endodermal cell differentiation epithelial cell differentiation gamete generation gland development gonad development hypothalamus development identical protein binding intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle localization macromolecule localization male gamete generation male gonad development male sex determination membrane-bounded organelle membrane molecular_function multicellular organismal reproductive process negative regulation of DNA-binding transcription factor activity negative regulation of DNA-templated transcription negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of biological process negative regulation of biosynthetic process negative regulation of cell communication negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of lipid biosynthetic process negative regulation of lipid metabolic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of molecular function negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of steroid biosynthetic process negative regulation of steroid metabolic process negative regulation of transcription by RNA polymerase II non-membrane-bounded organelle nuclear body nuclear receptor binding nuclear speck nucleic acid binding nucleoplasm nucleus organelle organic cyclic compound binding pituitary gland development protein binding protein dimerization activity protein domain specific binding protein homodimerization activity protein localization protein-DNA complex protein-containing complex regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of biological process regulation of biosynthetic process regulation of cell communication regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of gene expression regulation of intracellular steroid hormone receptor signaling pathway regulation of lipid biosynthetic process regulation of lipid metabolic process regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of primary metabolic process regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of steroid biosynthetic process regulation of steroid metabolic process regulation of transcription by RNA polymerase II reproductive process reproductive structure development response to immobilization stress response to stimulus response to stress ribosome sex determination spermatogenesis transcription coregulator activity transcription corepressor activity transcription factor binding transcription regulator activity	GO:0000122 GO:0000217 GO:0000785 GO:0003006 GO:0003674 GO:0003676 GO:0003677 GO:0003712 GO:0003714 GO:0003723 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005737 GO:0005840 GO:0006355 GO:0006357 GO:0006950 GO:0007276 GO:0007283 GO:0007530 GO:0008104 GO:0008134 GO:0008150 GO:0008406 GO:0008584 GO:0009889 GO:0009890 GO:0009892 GO:0009966 GO:0009968 GO:0009987 GO:0010468 GO:0010556 GO:0010558 GO:0010605 GO:0010646 GO:0010648 GO:0010894 GO:0016020 GO:0016604 GO:0016607 GO:0016922 GO:0019216 GO:0019218 GO:0019219 GO:0019222 GO:0019904 GO:0021854 GO:0021983 GO:0022414 GO:0023051 GO:0023057 GO:0030154 GO:0030238 GO:0030325 GO:0030855 GO:0031323 GO:0031324 GO:0031326 GO:0031327 GO:0032448 GO:0032502 GO:0032991 GO:0032993 GO:0033036 GO:0033143 GO:0033144 GO:0033327 GO:0034451 GO:0035902 GO:0035987 GO:0042802 GO:0042803 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043433 GO:0044092 GO:0045833 GO:0045892 GO:0045934 GO:0045939 GO:0046890 GO:0046983 GO:0048232 GO:0048513 GO:0048519 GO:0048523 GO:0048583 GO:0048585 GO:0048608 GO:0048609 GO:0048732 GO:0048856 GO:0048869 GO:0050682 GO:0050789 GO:0050794 GO:0050810 GO:0050896 GO:0051055 GO:0051090 GO:0051171 GO:0051172 GO:0051179 GO:0051252 GO:0051253 GO:0051641 GO:0060008 GO:0060255 GO:0061629 GO:0065007 GO:0065009 GO:0070727 GO:0080090 GO:0097159 GO:0110165 GO:0140110 GO:0140297 GO:1902679 GO:2001141
191	adenosylhomocysteinase	AHCY Aliases: AdoHcyase SAHH	Homo sapiens (human)	9606			S-adenosylmethionine cycle S-adenosylmethionine metabolic process adenosylhomocysteinase activity binding biological_process catalytic activity cellular anatomical entity cellular metabolic process cellular process cellular_component cytoplasmic vesicle cytosol endoplasmic reticulum extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle hydrolase activity, acting on carbon-sulfur bonds hydrolase activity intracellular membrane-bounded organelle intracellular organelle intracellular vesicle melanosome membrane-bounded organelle metabolic process molecular_function nucleus one-carbon metabolic process organelle organic substance metabolic process pigment granule protein binding small molecule metabolic process sulfur compound metabolic process vesicle	GO:0003674 GO:0003824 GO:0004013 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005783 GO:0005829 GO:0006730 GO:0006790 GO:0008150 GO:0008152 GO:0009987 GO:0016787 GO:0031410 GO:0031982 GO:0033353 GO:0042470 GO:0043226 GO:0043227 GO:0043229 GO:0043230 GO:0043231 GO:0044237 GO:0044281 GO:0046500 GO:0046508 GO:0048770 GO:0065010 GO:0070062 GO:0071704 GO:0097708 GO:0110165 GO:1903561
196	aryl hydrocarbon receptor	AHR	Homo sapiens (human)	9606			DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor binding E-box binding Hsp90 protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II general transcription initiation factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding TBP-class protein binding TFIID-class transcription factor complex binding anatomical structure development apoptotic process aryl hydrocarbon receptor complex basal RNA polymerase II transcription machinery binding basal transcription machinery binding binding biological regulation biological_process blood vessel development cAMP-mediated signaling cell death cellular anatomical entity cellular metabolic process cellular process cellular response to 2,3,7,8-tetrachlorodibenzodioxine cellular response to alcohol cellular response to biotic stimulus cellular response to cAMP cellular response to chemical stimulus cellular response to endogenous stimulus cellular response to forskolin cellular response to ketone cellular response to lipid cellular response to molecule of bacterial origin cellular response to nitrogen compound cellular response to organic cyclic compound cellular response to organic substance cellular response to organonitrogen compound cellular response to oxygen-containing compound cellular response to stimulus cellular_component chromatin circadian regulation of gene expression circadian rhythm cis-regulatory region sequence-specific DNA binding cyclic-nucleotide-mediated signaling cytoplasm cytosol cytosolic aryl hydrocarbon receptor complex developmental process double-stranded DNA binding general transcription initiation factor binding heat shock protein binding identical protein binding intracellular membrane-bounded organelle intracellular organelle intracellular protein-containing complex intracellular receptor signaling pathway intracellular signal transduction ligand-activated transcription factor activity membrane-bounded organelle metabolic process molecular transducer activity molecular_function negative regulation of DNA-templated transcription negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of T cell mediated immune response to tumor cell negative regulation of T cell mediated immunity negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of adaptive immune response negative regulation of biological process negative regulation of biosynthetic process negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of defense response negative regulation of immune effector process negative regulation of immune response to tumor cell negative regulation of immune response negative regulation of immune system process negative regulation of inflammatory response negative regulation of leukocyte mediated immunity negative regulation of lymphocyte mediated immunity negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of response to biotic stimulus negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of response to tumor cell nuclear aryl hydrocarbon receptor complex nuclear protein-containing complex nuclear receptor activity nucleic acid binding nucleoplasm nucleus organelle organic cyclic compound binding positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II programmed cell death protein binding protein dimerization activity protein heterodimerization activity protein homodimerization activity protein-DNA complex protein-containing complex binding protein-containing complex receptor complex regulation of B cell activation regulation of B cell proliferation regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of T cell mediated immune response to tumor cell regulation of T cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of biological process regulation of biosynthetic process regulation of cell activation regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of defense response regulation of gene expression regulation of immune effector process regulation of immune response to tumor cell regulation of immune response regulation of immune system process regulation of inflammatory response regulation of leukocyte activation regulation of leukocyte mediated immunity regulation of leukocyte proliferation regulation of lymphocyte activation regulation of lymphocyte mediated immunity regulation of lymphocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of primary metabolic process regulation of response to biotic stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of response to tumor cell regulation of transcription by RNA polymerase II response to 2,3,7,8-tetrachlorodibenzodioxine response to alcohol response to biotic stimulus response to cAMP response to chemical response to endogenous stimulus response to external biotic stimulus response to external stimulus response to forskolin response to ketone response to lipid response to molecule of bacterial origin response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to purine-containing compound response to stimulus response to toxic substance response to xenobiotic stimulus rhythmic process second-messenger-mediated signaling sequence-specific DNA binding sequence-specific double-stranded DNA binding signal transduction signaling receptor activity transcription cis-regulatory region binding transcription coactivator binding transcription coregulator binding transcription factor binding transcription regulator activity transcription regulator complex transcription regulatory region nucleic acid binding xenobiotic metabolic process	GO:0000785 GO:0000976 GO:0000977 GO:0000978 GO:0000981 GO:0000987 GO:0001067 GO:0001091 GO:0001094 GO:0001098 GO:0001099 GO:0001221 GO:0001223 GO:0001568 GO:0002237 GO:0002682 GO:0002683 GO:0002694 GO:0002697 GO:0002698 GO:0002703 GO:0002704 GO:0002706 GO:0002707 GO:0002709 GO:0002710 GO:0002819 GO:0002820 GO:0002822 GO:0002823 GO:0002831 GO:0002832 GO:0002834 GO:0002835 GO:0002837 GO:0002838 GO:0002840 GO:0002841

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