GlyCosmos Portal

GlyCosmos Genes

Integrated list of glycan-related genes extracted KEGG GENES Database, UniProt, GlycoGene Database (GGDB), Plant GARDEN and FlyGlycoDB. Glycan-related genes including glycosyltransferase, hydrolase activity (acting on glycosyl bonds), carbohydrate metabolic process, etc .

Source	Last Updated
FlyGlycoDB	March 25, 2024
GlycoGene Database (GGDB)	January 26, 2018
KEGG GENES Database	September 20, 2023
Plant GARDEN	May 28, 2020
UniProt	October 29, 2024

Selecting the function you want to look up from the categories displays a list narrowed down to glycan-related genes with that function (Gene Ontology).

Catalytic activity

glycosyltransferase activity

hydrolase activity, acting on glycosyl bonds

Binding

carbohydrate binding

Response to carbohydrate

Primary metabolic process

Displaying entries **1576 - 1600** of **10109** in total

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Gene ID ▲	Gene Name	Gene Symbol	Organism	Taxonomy ID	Disease Ontology	Disease Ontology ID	Gene Ontology	Gene Ontology ID
3554	interleukin 1 receptor type 1	IL1R1 Aliases: CD121A D2S1473 interleukin-1 receptor, type I	Homo sapiens (human)	9606	chronic recurrent multifocal osteomyelitis systemic scleroderma type 1 diabetes mellitus	DOID:0060645 DOID:418 DOID:9744	NAD+ nucleosidase activity NAD+ nucleotidase, cyclic ADP-ribose generating binding biological regulation biological_process catalytic activity cell surface receptor signaling pathway cell surface cellular anatomical entity cellular process cellular_component cytokine binding cytokine receptor activity cytokine-mediated signaling pathway defense response enzyme binding external side of plasma membrane extracellular region growth factor binding growth factor receptor binding hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds hydrolase activity immune receptor activity immune response immune system process inflammatory response interleukin-1 binding interleukin-1 receptor activity interleukin-1, type I, activating receptor activity interleukin-1-mediated signaling pathway membrane molecular transducer activity molecular_function multicellular organismal process muscle adaptation muscle system process plasma membrane platelet-derived growth factor receptor binding positive regulation of T cell cytokine production positive regulation of T cell mediated immunity positive regulation of T-helper 1 cell cytokine production positive regulation of T-helper 1 type immune response positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response positive regulation of biological process positive regulation of biosynthetic process positive regulation of canonical NF-kappaB signal transduction positive regulation of cell communication positive regulation of cell migration positive regulation of cell motility positive regulation of cellular biosynthetic process positive regulation of cellular extravasation positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production involved in immune response positive regulation of cytokine production positive regulation of cytokine-mediated signaling pathway positive regulation of gene expression positive regulation of immune effector process positive regulation of immune response positive regulation of immune system process positive regulation of interleukin-1-mediated signaling pathway positive regulation of intracellular signal transduction positive regulation of leukocyte mediated immunity positive regulation of leukocyte migration positive regulation of locomotion positive regulation of lymphocyte mediated immunity positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of neutrophil extravasation positive regulation of neutrophil migration positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of production of molecular mediator of immune response positive regulation of response to cytokine stimulus positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of type II interferon production protease binding protein binding regulation of T cell cytokine production regulation of T cell mediated immunity regulation of T-helper 1 cell cytokine production regulation of T-helper 1 type immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of biological process regulation of biosynthetic process regulation of canonical NF-kappaB signal transduction regulation of cell communication regulation of cell migration regulation of cell motility regulation of cellular biosynthetic process regulation of cellular extravasation regulation of cellular metabolic process regulation of cellular process regulation of cytokine production involved in immune response regulation of cytokine production regulation of cytokine-mediated signaling pathway regulation of defense response regulation of gene expression regulation of immune effector process regulation of immune response regulation of immune system process regulation of inflammatory response regulation of interleukin-1-mediated signaling pathway regulation of intracellular signal transduction regulation of leukocyte mediated immunity regulation of leukocyte migration regulation of locomotion regulation of lymphocyte mediated immunity regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process regulation of neutrophil extravasation regulation of neutrophil migration regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of platelet-derived growth factor receptor signaling pathway regulation of production of molecular mediator of immune response regulation of response to cytokine stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of signal transduction regulation of signaling regulation of type II interferon production response to chemical response to cytokine response to interleukin-1 response to organic substance response to stimulus response to stress side of membrane signal transduction signaling receptor activity signaling receptor binding smooth muscle adaptation system process transmembrane signaling receptor activity	GO:0001817 GO:0001819 GO:0001959 GO:0001961 GO:0002020 GO:0002376 GO:0002682 GO:0002684 GO:0002685 GO:0002687 GO:0002691 GO:0002693 GO:0002697 GO:0002699 GO:0002700 GO:0002702 GO:0002703 GO:0002705 GO:0002706 GO:0002708 GO:0002709 GO:0002711 GO:0002718 GO:0002720 GO:0002724 GO:0002726 GO:0002819 GO:0002821 GO:0002822 GO:0002824 GO:0002825 GO:0002827 GO:0003008 GO:0003012 GO:0003674 GO:0003824 GO:0003953 GO:0004888 GO:0004896 GO:0004908 GO:0004909 GO:0005102 GO:0005161 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005886 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0007165 GO:0007166 GO:0008150 GO:0009889 GO:0009891 GO:0009893 GO:0009897 GO:0009966 GO:0009967 GO:0009986 GO:0009987 GO:0010033 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0010640 GO:0010641 GO:0010646 GO:0010647 GO:0014805 GO:0016020 GO:0016787 GO:0016798 GO:0016799 GO:0019221 GO:0019222 GO:0019838 GO:0019899 GO:0019955 GO:0019966 GO:0023051 GO:0023056 GO:0030334 GO:0030335 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031347 GO:0032101 GO:0032501 GO:0032649 GO:0032729 GO:0034097 GO:0038023 GO:0040012 GO:0040017 GO:0042221 GO:0043122 GO:0043123 GO:0043500 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0050727 GO:0050776 GO:0050778 GO:0050789 GO:0050794 GO:0050896 GO:0051239 GO:0051240 GO:0051896 GO:0051897 GO:0060089 GO:0060255 GO:0060759 GO:0060760 GO:0061809 GO:0065007 GO:0070498 GO:0070555 GO:0070851 GO:0080134 GO:0098552 GO:0110165 GO:0140375 GO:1902531 GO:1902533 GO:1902622 GO:1902624 GO:2000145 GO:2000147 GO:2000389 GO:2000391 GO:2000554 GO:2000556 GO:2000659 GO:2000661
3556	interleukin 1 receptor accessory protein	IL1RAP Aliases: C3orf13 IL-1RAcP IL1R3	Homo sapiens (human)	9606			NAD+ nucleosidase activity NAD+ nucleotidase, cyclic ADP-ribose generating binding biological process involved in interspecies interaction between organisms biological regulation biological_process catalytic activity cell adhesion cell communication cell junction cell surface receptor signaling pathway cell surface cell-cell adhesion via plasma-membrane adhesion molecules cell-cell adhesion cell-cell signaling cellular anatomical entity cellular component assembly cellular component organization or biogenesis cellular component organization cellular process cellular_component coreceptor activity cytokine receptor activity cytokine receptor binding cytokine-mediated signaling pathway defense response to other organism defense response extracellular region glutamatergic synapse growth factor receptor binding hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds hydrolase activity immune receptor activity immune response immune system process inflammatory response innate immune response interleukin-1 receptor activity interleukin-1 receptor binding interleukin-1-mediated signaling pathway interleukin-33 receptor activity interleukin-33-mediated signaling pathway membrane molecular transducer activity molecular_function plasma membrane positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell junction assembly positive regulation of cellular biosynthetic process positive regulation of cellular component biogenesis positive regulation of cellular component organization positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of developmental process positive regulation of gene expression positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production positive regulation of interleukin-6 production positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of multicellular organismal process positive regulation of nervous system development positive regulation of synapse assembly protein binding protein-containing complex assembly protein-containing complex organization regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of biological process regulation of biosynthetic process regulation of cell junction assembly regulation of cellular biosynthetic process regulation of cellular component biogenesis regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cytokine production regulation of developmental process regulation of excitatory synapse assembly regulation of gene expression regulation of interleukin-13 production regulation of interleukin-4 production regulation of interleukin-5 production regulation of interleukin-6 production regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of multicellular organismal development regulation of multicellular organismal process regulation of nervous system development regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of organelle assembly regulation of organelle organization regulation of postsynapse organization regulation of postsynaptic density assembly regulation of postsynaptic density organization regulation of postsynaptic specialization assembly regulation of presynapse assembly regulation of presynapse organization regulation of primary metabolic process regulation of synapse assembly regulation of synapse organization response to biotic stimulus response to external biotic stimulus response to external stimulus response to other organism response to stimulus response to stress signal transduction signaling receptor activity signaling receptor binding signaling synapse synaptic membrane adhesion synaptic signaling trans-synaptic signaling by trans-synaptic complex trans-synaptic signaling transmembrane signaling receptor activity	GO:0001817 GO:0001819 GO:0002114 GO:0002376 GO:0003674 GO:0003824 GO:0003953 GO:0004888 GO:0004896 GO:0004908 GO:0005102 GO:0005126 GO:0005149 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005886 GO:0006355 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0007154 GO:0007155 GO:0007165 GO:0007166 GO:0007267 GO:0008150 GO:0009605 GO:0009607 GO:0009889 GO:0009891 GO:0009893 GO:0009986 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0015026 GO:0016020 GO:0016043 GO:0016787 GO:0016798 GO:0016799 GO:0019219 GO:0019221 GO:0019222 GO:0022607 GO:0023052 GO:0030054 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0032656 GO:0032673 GO:0032674 GO:0032675 GO:0032736 GO:0032753 GO:0032754 GO:0032755 GO:0033043 GO:0038023 GO:0038172 GO:0043207 GO:0043933 GO:0044087 GO:0044089 GO:0044093 GO:0044419 GO:0045087 GO:0045202 GO:0048518 GO:0048522 GO:0050789 GO:0050793 GO:0050794 GO:0050807 GO:0050896 GO:0051090 GO:0051091 GO:0051092 GO:0051094 GO:0051128 GO:0051130 GO:0051171 GO:0051239 GO:0051240 GO:0051252 GO:0051707 GO:0051960 GO:0051962 GO:0051963 GO:0051965 GO:0060089 GO:0060255 GO:0061809 GO:0065003 GO:0065007 GO:0065009 GO:0070498 GO:0070851 GO:0071840 GO:0080090 GO:0098542 GO:0098609 GO:0098742 GO:0098978 GO:0099150 GO:0099151 GO:0099174 GO:0099175 GO:0099536 GO:0099537 GO:0099545 GO:0099560 GO:0110165 GO:0140375 GO:1901888 GO:1901890 GO:1902115 GO:1904889 GO:1905606 GO:1905874 GO:2000026 GO:2001141
3557	interleukin 1 receptor antagonist	IL1RN	Homo sapiens (human)	9606	Graves ophthalmopathy IgA glomerulonephritis IgA vasculitis Muckle-Wells syndrome Schnitzler syndrome Sjogren's syndrome acute kidney failure acute necrotizing pancreatitis allergic conjunctivitis alopecia areata anterior uveitis asthma autoimmune thrombocytopenic purpura bronchopulmonary dysplasia calcium oxalate nephrolithiasis chronic kidney disease chronic obstructive pulmonary disease chronic recurrent multifocal osteomyelitis common cold corneal neovascularization crescentic glomerulonephritis dacryocystitis depressive disorder diabetic angiopathy end stage renal disease glomerulonephritis graft-versus-host disease hemolytic-uremic syndrome herpes simplex virus keratitis hypertension inflammatory bowel disease keratoconus learning disability listeriosis lung non-small cell carcinoma melanoma middle cerebral artery infarction multiple myeloma nephrotic syndrome nicotine dependence osteoporosis periodontitis pleural tuberculosis pleurisy pneumonia proteinuria pulmonary fibrosis pulmonary hypertension pulmonary tuberculosis renal cell carcinoma rheumatoid arthritis rhinitis sciatic neuropathy silicosis stomach cancer systemic lupus erythematosus toxic shock syndrome transient cerebral ischemia type 1 diabetes mellitus type 2 diabetes mellitus ulcerative colitis ureteral obstruction urinary bladder cancer vascular disease	DOID:0050589 DOID:0050742 DOID:0050854 DOID:0060645 DOID:0080158 DOID:0080652 DOID:0080998 DOID:0081120 DOID:0081267 DOID:10126 DOID:10247 DOID:10325 DOID:10459 DOID:10534 DOID:106 DOID:10763 DOID:11054 DOID:11123 DOID:11204 DOID:11382 DOID:11446 DOID:11476 DOID:11573 DOID:11650 DOID:11713 DOID:1184 DOID:12554 DOID:12894 DOID:13139 DOID:1407 DOID:14115 DOID:1596 DOID:178 DOID:1909 DOID:224 DOID:2841 DOID:2921 DOID:2957 DOID:2986 DOID:3021 DOID:3083 DOID:3525 DOID:3770 DOID:3908 DOID:4371 DOID:4450 DOID:4483 DOID:5199 DOID:552 DOID:576 DOID:6432 DOID:7148 DOID:783 DOID:784 DOID:824 DOID:8577 DOID:8924 DOID:8927 DOID:9074 DOID:9352 DOID:9538 DOID:9744 DOID:986 DOID:9938	acute inflammatory response acute-phase response amide transport binding biological regulation biological_process cellular anatomical entity cellular localization cellular macromolecule localization cellular process cellular_component centrosome cytokine activity cytokine binding cytokine receptor binding cytosol defense response establishment of localization establishment of protein localization to extracellular region establishment of protein localization export from cell extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular space extracellular vesicle growth factor binding growth factor receptor binding hormone secretion hormone transport immune response immune system process inflammatory response to antigenic stimulus inflammatory response insulin secretion interleukin-1 binding interleukin-1 receptor antagonist activity interleukin-1 receptor binding interleukin-1 type I receptor antagonist activity interleukin-1 type II receptor antagonist activity interleukin-1, type I receptor binding interleukin-1, type II receptor binding lipid metabolic process localization macromolecule localization membrane-bounded organelle membrane metabolic process microtubule organizing center molecular function activator activity molecular function inhibitor activity molecular function regulator activity molecular_function negative regulation of biological process negative regulation of cell adhesion negative regulation of cell communication negative regulation of cell-cell adhesion negative regulation of cellular process negative regulation of cytokine-mediated signaling pathway negative regulation of heterotypic cell-cell adhesion negative regulation of interleukin-1-mediated signaling pathway negative regulation of response to cytokine stimulus negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling nitrogen compound transport nucleoplasm organelle organic substance metabolic process organic substance transport peptide hormone secretion peptide secretion peptide transport plasma membrane primary metabolic process protein binding protein localization to extracellular region protein localization protein secretion protein transport receptor antagonist activity receptor ligand activity regulation of biological process regulation of biological quality regulation of cell adhesion regulation of cell communication regulation of cell-cell adhesion involved in gastrulation regulation of cell-cell adhesion regulation of cellular process regulation of cytokine-mediated signaling pathway regulation of heterotypic cell-cell adhesion regulation of hormone levels regulation of interleukin-1-mediated signaling pathway regulation of response to cytokine stimulus regulation of response to stimulus regulation of signal transduction regulation of signaling response to chemical response to corticosteroid response to endogenous stimulus response to glucocorticoid response to hormone response to lipid response to organic cyclic compound response to organic substance response to steroid hormone response to stimulus response to stress secretion by cell secretion signal release signal transduction signaling receptor activator activity signaling receptor binding signaling receptor inhibitor activity signaling receptor regulator activity transport vesicle	GO:0001959 GO:0001960 GO:0002376 GO:0002437 GO:0002526 GO:0002790 GO:0003674 GO:0005102 GO:0005125 GO:0005126 GO:0005149 GO:0005150 GO:0005151 GO:0005152 GO:0005488 GO:0005515 GO:0005575 GO:0005615 GO:0005654 GO:0005813 GO:0005815 GO:0005829 GO:0005886 GO:0006629 GO:0006810 GO:0006950 GO:0006952 GO:0006953 GO:0006954 GO:0006955 GO:0007162 GO:0007165 GO:0008104 GO:0008150 GO:0008152 GO:0009306 GO:0009719 GO:0009725 GO:0009914 GO:0009966 GO:0009968 GO:0009987 GO:0010033 GO:0010646 GO:0010648 GO:0010817 GO:0014070 GO:0015031 GO:0015833 GO:0016020 GO:0019838 GO:0019955 GO:0019966 GO:0022407 GO:0022408 GO:0023051 GO:0023057 GO:0023061 GO:0030072 GO:0030073 GO:0030155 GO:0030545 GO:0030546 GO:0030547 GO:0031960 GO:0031982 GO:0032940 GO:0033036 GO:0033993 GO:0034114 GO:0034115 GO:0035592 GO:0042221 GO:0042886 GO:0043226 GO:0043227 GO:0043230 GO:0044238 GO:0045184 GO:0045352 GO:0045353 GO:0046879 GO:0046903 GO:0048018 GO:0048019 GO:0048519 GO:0048523 GO:0048545 GO:0048583 GO:0048585 GO:0050789 GO:0050794 GO:0050896 GO:0051179 GO:0051234 GO:0051384 GO:0051641 GO:0060759 GO:0060761 GO:0065007 GO:0065008 GO:0065010 GO:0070062 GO:0070587 GO:0070727 GO:0070851 GO:0071692 GO:0071702 GO:0071704 GO:0071705 GO:0098772 GO:0110165 GO:0140352 GO:0140677 GO:0140678 GO:1903561 GO:2000659 GO:2000660
3558	interleukin 2	IL2	Homo sapiens (human)	9606	Alzheimer's disease Behcet's disease Graves ophthalmopathy Graves' disease Takayasu's arteritis alopecia areata asthma ataxia telangiectasia atopic dermatitis autoimmune thrombocytopenic purpura bullous pemphigoid cholesteatoma of middle ear drug allergy graft-versus-host disease head and neck squamous cell carcinoma hepatocellular carcinoma high grade glioma interstitial lung disease limited scleroderma oral squamous cell carcinoma pancreatic cancer pemphigus primary immunodeficiency disease renal cell carcinoma rheumatoid arthritis rhinitis sensorineural hearing loss squamous cell carcinoma systemic lupus erythematosus type 1 diabetes mellitus urinary bladder cancer viral hepatitis	DOID:0050866 DOID:0060500 DOID:0081120 DOID:0081267 DOID:10003 DOID:10652 DOID:10964 DOID:11054 DOID:12361 DOID:12704 DOID:13241 DOID:1577 DOID:1749 DOID:1793 DOID:1884 DOID:2508 DOID:2841 DOID:3070 DOID:3082 DOID:3310 DOID:4450 DOID:4483 DOID:5520 DOID:612 DOID:684 DOID:7148 DOID:8506 DOID:8924 DOID:9074 DOID:9182 DOID:9744 DOID:986	DNA-templated transcription G protein-coupled receptor binding G protein-coupled receptor signaling pathway RNA biosynthetic process RNA metabolic process T cell activation T cell differentiation T cell proliferation activated T cell proliferation adaptive immune response apoptotic signaling pathway aromatic compound biosynthetic process binding biological regulation biological_process biosynthetic process carbohydrate binding carbohydrate derivative binding cell activation involved in immune response cell activation cell adhesion cell communication cell differentiation cell population proliferation cell surface receptor signaling pathway cell-cell signaling cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular developmental process cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular_component cytokine activity cytokine receptor binding cytokine-mediated signaling pathway developmental process enzyme activator activity enzyme regulator activity extracellular region extracellular space extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway glycolipid binding glycosphingolipid binding growth factor activity growth factor receptor binding heterocycle biosynthetic process heterocycle metabolic process immune effector process immune response immune system process interleukin-2 receptor binding interleukin-2-mediated signaling pathway kappa-type opioid receptor binding kinase activator activity kinase regulator activity leukocyte activation involved in immune response leukocyte activation leukocyte differentiation leukocyte proliferation lipid binding lymphocyte activation lymphocyte differentiation lymphocyte proliferation macromolecule biosynthetic process macromolecule metabolic process metabolic process molecular function activator activity molecular function regulator activity molecular_function mononuclear cell differentiation mononuclear cell proliferation multicellular organismal process natural killer cell activation negative regulation of B cell apoptotic process negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of T cell activation negative regulation of T cell differentiation negative regulation of T-helper 17 cell differentiation negative regulation of T-helper 17 type immune response negative regulation of T-helper cell differentiation negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of adaptive immune response negative regulation of alpha-beta T cell activation negative regulation of alpha-beta T cell differentiation negative regulation of apoptotic process negative regulation of biological process negative regulation of cell activation negative regulation of cell adhesion negative regulation of cell development negative regulation of cell differentiation negative regulation of cell population proliferation negative regulation of cell-cell adhesion negative regulation of cellular process negative regulation of defense response negative regulation of developmental process negative regulation of hemopoiesis negative regulation of immune effector process negative regulation of immune response negative regulation of immune system process negative regulation of inflammatory response negative regulation of leukocyte activation negative regulation of leukocyte apoptotic process negative regulation of leukocyte cell-cell adhesion negative regulation of leukocyte differentiation negative regulation of leukocyte proliferation negative regulation of lymphocyte activation negative regulation of lymphocyte apoptotic process negative regulation of lymphocyte differentiation negative regulation of lymphocyte proliferation negative regulation of mononuclear cell proliferation negative regulation of multicellular organismal process negative regulation of programmed cell death negative regulation of response to external stimulus negative regulation of response to stimulus nitrogen compound metabolic process nucleic acid metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process opioid receptor binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of B cell activation positive regulation of B cell differentiation positive regulation of B cell mediated immunity positive regulation of B cell proliferation positive regulation of DNA metabolic process positive regulation of DNA recombination positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of T cell activation positive regulation of T cell differentiation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell development positive regulation of cell differentiation positive regulation of cell growth positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of cytosolic calcium ion concentration positive regulation of defense response positive regulation of dendritic spine development positive regulation of developmental process positive regulation of gene expression positive regulation of growth positive regulation of hemopoiesis positive regulation of immune effector process positive regulation of immune response positive regulation of immune system process positive regulation of immunoglobulin mediated immune response positive regulation of immunoglobulin production positive regulation of inflammatory response positive regulation of interleukin-17 production positive regulation of isotype switching to IgG isotypes positive regulation of isotype switching positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte differentiation positive regulation of leukocyte mediated immunity positive regulation of leukocyte proliferation positive regulation of lymphocyte activation positive regulation of lymphocyte differentiation positive regulation of lymphocyte mediated immunity positive regulation of lymphocyte proliferation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of mononuclear cell proliferation positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of plasma cell differentiation positive regulation of production of molecular mediator of immune response positive regulation of regulatory T cell differentiation positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of tissue remodeling positive regulation of transcription by RNA polymerase II positive regulation of type II interferon production primary metabolic process protein binding receptor ligand activity receptor signaling pathway via STAT regulation of B cell activation regulation of B cell apoptotic process regulation of B cell differentiation regulation of B cell mediated immunity regulation of B cell proliferation regulation of CD4-positive, alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell differentiation regulation of CD4-positive, alpha-beta T cell proliferation regulation of DNA metabolic process regulation of DNA recombination regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of T cell activation regulation of T cell differentiation regulation of T cell homeostatic proliferation regulation of T cell proliferation regulation of T-helper 17 cell differentiation regulation of T-helper 17 type immune response regulation of T-helper cell differentiation regulation of activated T cell proliferation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of alpha-beta T cell activation regulation of alpha-beta T cell differentiation regulation of alpha-beta T cell proliferation regulation of apoptotic process regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of cell activation regulation of cell adhesion regulation of cell development regulation of cell differentiation regulation of cell growth regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cytokine production regulation of defense response regulation of dendritic spine development regulation of developmental process regulation of gene expression regulation of growth regulation of hemopoiesis regulation of immune effector process regulation of immune response regulation of immune system process regulation of immunoglobulin mediated immune response regulation of immunoglobulin production regulation of inflammatory response regulation of interleukin-17 production regulation of isotype switching to IgG isotypes regulation of isotype switching regulation of leukocyte activation regulation of leukocyte apoptotic process regulation of leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of leukocyte mediated immunity regulation of leukocyte proliferation regulation of lymphocyte activation regulation of lymphocyte apoptotic process regulation of lymphocyte differentiation regulation of lymphocyte mediated immunity regulation of lymphocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of mononuclear cell proliferation regulation of multicellular organismal development regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of plasma cell differentiation regulation of primary metabolic process regulation of production of molecular mediator of immune response regulation of programmed cell death regulation of regulatory T cell differentiation regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of tissue remodeling regulation of transcription by RNA polymerase II regulation of type II interferon production response to alcohol response to chemical response to ethanol response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to oxygen-containing compound response to stimulus response to tacrolimus signal transduction in absence of ligand signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity signaling sphingolipid binding transcription by RNA polymerase II	GO:0000018 GO:0001558 GO:0001664 GO:0001775 GO:0001817 GO:0001819 GO:0002250 GO:0002252 GO:0002263 GO:0002366 GO:0002376 GO:0002521 GO:0002637 GO:0002639 GO:0002682 GO:0002683 GO:0002684 GO:0002694 GO:0002695 GO:0002696 GO:0002697 GO:0002698 GO:0002699 GO:0002700 GO:0002702 GO:0002703 GO:0002705 GO:0002706 GO:0002708 GO:0002712 GO:0002714 GO:0002819 GO:0002820 GO:0002821 GO:0002822 GO:0002823 GO:0002824 GO:0002889 GO:0002891 GO:0002902 GO:0002903 GO:0003674 GO:0005102 GO:0005125 GO:0005126 GO:0005134 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0006139 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0006725 GO:0006807 GO:0006955 GO:0007154 GO:0007155 GO:0007162 GO:0007165 GO:0007166 GO:0007186 GO:0007200 GO:0007204 GO:0007267 GO:0008047 GO:0008083 GO:0008150 GO:0008152 GO:0008283 GO:0008284 GO:0008285 GO:0008289 GO:0009058 GO:0009059 GO:0009889 GO:0009891 GO:0009893 GO:0009987 GO:0010033 GO:0010243 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0010720 GO:0010721 GO:0014070 GO:0016070 GO:0018130 GO:0019207 GO:0019209 GO:0019219 GO:0019221 GO:0019222 GO:0019438 GO:0022407 GO:0022408 GO:0022409 GO:0023052 GO:0030098 GO:0030101 GO:0030154 GO:0030155 GO:0030217 GO:0030234 GO:0030246 GO:0030307 GO:0030545 GO:0030546 GO:0030888 GO:0030890 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031347 GO:0031348 GO:0031349 GO:0031628 GO:0031851 GO:0032101 GO:0032102 GO:0032103 GO:0032501 GO:0032502 GO:0032649 GO:0032660 GO:0032729 GO:0032740 GO:0032774 GO:0032943 GO:0032944 GO:0032945 GO:0032946 GO:0034103 GO:0034105 GO:0034641 GO:0034654 GO:0038034 GO:0038110 GO:0040008 GO:0042098 GO:0042102 GO:0042104 GO:0042110 GO:0042127 GO:0042129 GO:0042221 GO:0042981 GO:0043066 GO:0043067 GO:0043069 GO:0043170 GO:0043208 GO:0043370 GO:0043371 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0045191 GO:0045321 GO:0045471 GO:0045577 GO:0045579 GO:0045580 GO:0045581 GO:0045582 GO:0045589 GO:0045591 GO:0045595 GO:0045596 GO:0045597 GO:0045619 GO:0045620 GO:0045621 GO:0045622 GO:0045623 GO:0045785 GO:0045830 GO:0045893 GO:0045911 GO:0045927 GO:0045935 GO:0045944 GO:0046006 GO:0046013 GO:0046483 GO:0046625 GO:0046634 GO:0046636 GO:0046637 GO:0046639 GO:0046640 GO:0046649 GO:0046651 GO:0048018 GO:0048302 GO:0048304 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048869 GO:0050670 GO:0050671 GO:0050672 GO:0050727 GO:0050728 GO:0050729 GO:0050776 GO:0050777 GO:0050778 GO:0050789 GO:0050793 GO:0050794 GO:0050798 GO:0050863 GO:0050864 GO:0050865 GO:0050866 GO:0050867 GO:0050868 GO:0050870 GO:0050871 GO:0050896 GO:0051052 GO:0051054 GO:0051093 GO:0051094 GO:0051128 GO:0051171 GO:0051173 GO:0051239 GO:0051240 GO:0051241 GO:0051249 GO:0051250 GO:0051251 GO:0051252 GO:0051254 GO:0051861 GO:0060255 GO:0060284 GO:0060998 GO:0060999 GO:0065007 GO:0065008 GO:0070228 GO:0070229 GO:0070661 GO:0070663 GO:0070664 GO:0070665 GO:0070851 GO:0071704 GO:0080090 GO:0080134 GO:0090304 GO:0097190 GO:0097191 GO:0097192 GO:0097305 GO:0097367 GO:0097696 GO:0098772 GO:0110165 GO:0140677 GO:1900098 GO:1900100 GO:1901327 GO:1901360 GO:1901362 GO:1901576 GO:1901698 GO:1901700 GO:1902105 GO:1902106 GO:1902107 GO:1902680 GO:1903037 GO:1903038 GO:1903039 GO:1903131 GO:1903706 GO:1903707 GO:1903708 GO:2000026 GO:2000106 GO:2000107 GO:2000316 GO:2000317 GO:2000319 GO:2000320 GO:2000514 GO:2000515 GO:2000561 GO:2001141
3559	interleukin 2 receptor subunit alpha	IL2RA	Homo sapiens (human)	9606	immunodeficiency 41 lymphopenia multiple sclerosis type 1 diabetes mellitus 10 type 1 diabetes mellitus	DOID:0110749 DOID:0111968 DOID:2377 DOID:614 DOID:9744	Notch signaling pathway T cell activation T cell apoptotic process T cell proliferation activated T cell proliferation activation-induced cell death of T cells apoptotic process binding biological regulation biological_process cell activation cell death cell population proliferation cell surface receptor signaling pathway cellular anatomical entity cellular process cellular_component cytokine binding cytokine receptor activity cytokine-mediated signaling pathway defense response external side of plasma membrane growth factor binding immune receptor activity immune response immune system process inflammatory response to antigenic stimulus inflammatory response interleukin-2 binding interleukin-2 receptor activity interleukin-2 receptor complex interleukin-2-mediated signaling pathway leukocyte activation leukocyte apoptotic process leukocyte proliferation lymphocyte activation lymphocyte apoptotic process lymphocyte proliferation membrane protein complex membrane molecular transducer activity molecular_function mononuclear cell proliferation multicellular organismal process negative regulation of T cell activation negative regulation of T cell proliferation negative regulation of biological process negative regulation of cell activation negative regulation of cell adhesion negative regulation of cell population proliferation negative regulation of cell-cell adhesion negative regulation of cellular process negative regulation of defense response negative regulation of immune system process negative regulation of inflammatory response negative regulation of leukocyte activation negative regulation of leukocyte cell-cell adhesion negative regulation of leukocyte proliferation negative regulation of lymphocyte activation negative regulation of lymphocyte proliferation negative regulation of mononuclear cell proliferation negative regulation of multicellular organismal process negative regulation of response to external stimulus negative regulation of response to stimulus plasma membrane protein complex plasma membrane signaling receptor complex plasma membrane positive regulation of T cell activation positive regulation of T cell differentiation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of biological process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell development positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular process positive regulation of developmental process positive regulation of hemopoiesis positive regulation of immune system process positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte differentiation positive regulation of leukocyte proliferation positive regulation of lymphocyte activation positive regulation of lymphocyte differentiation positive regulation of lymphocyte proliferation positive regulation of mononuclear cell proliferation positive regulation of multicellular organismal process programmed cell death protein binding protein-containing complex receptor complex regulation of CD4-positive, alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell proliferation regulation of T cell activation regulation of T cell differentiation regulation of T cell homeostatic proliferation regulation of T cell proliferation regulation of T cell tolerance induction regulation of activated T cell proliferation regulation of alpha-beta T cell activation regulation of alpha-beta T cell proliferation regulation of biological process regulation of cell activation regulation of cell adhesion regulation of cell development regulation of cell differentiation regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular process regulation of defense response regulation of developmental process regulation of hemopoiesis regulation of immune system process regulation of inflammatory response regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of leukocyte proliferation regulation of lymphocyte activation regulation of lymphocyte differentiation regulation of lymphocyte proliferation regulation of mononuclear cell proliferation regulation of multicellular organismal development regulation of multicellular organismal process regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of tolerance induction response to stimulus response to stress side of membrane signal transduction signaling receptor activity transmembrane signaling receptor activity	GO:0001775 GO:0002376 GO:0002437 GO:0002643 GO:0002664 GO:0002682 GO:0002683 GO:0002684 GO:0002694 GO:0002695 GO:0002696 GO:0003674 GO:0004888 GO:0004896 GO:0004911 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0005893 GO:0006915 GO:0006924 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0007162 GO:0007165 GO:0007166 GO:0007219 GO:0008150 GO:0008219 GO:0008283 GO:0008284 GO:0008285 GO:0009897 GO:0009987 GO:0010720 GO:0012501 GO:0016020 GO:0019221 GO:0019838 GO:0019955 GO:0019976 GO:0022407 GO:0022408 GO:0022409 GO:0030155 GO:0031347 GO:0031348 GO:0032101 GO:0032102 GO:0032501 GO:0032943 GO:0032944 GO:0032945 GO:0032946 GO:0032991 GO:0038023 GO:0038110 GO:0042098 GO:0042102 GO:0042104 GO:0042110 GO:0042127 GO:0042129 GO:0042130 GO:0043235 GO:0045321 GO:0045580 GO:0045582 GO:0045595 GO:0045597 GO:0045619 GO:0045621 GO:0045785 GO:0046006 GO:0046013 GO:0046634 GO:0046640 GO:0046649 GO:0046651 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048585 GO:0050670 GO:0050671 GO:0050672 GO:0050727 GO:0050728 GO:0050789 GO:0050793 GO:0050794 GO:0050798 GO:0050863 GO:0050865 GO:0050866 GO:0050867 GO:0050868 GO:0050870 GO:0050896 GO:0051094 GO:0051239 GO:0051240 GO:0051241 GO:0051249 GO:0051250 GO:0051251 GO:0060089 GO:0060284 GO:0065007 GO:0070227 GO:0070231 GO:0070661 GO:0070663 GO:0070664 GO:0070665 GO:0071887 GO:0080134 GO:0098552 GO:0098796 GO:0098797 GO:0098802 GO:0110165 GO:0140375 GO:1902105 GO:1902107 GO:1903037 GO:1903038 GO:1903039 GO:1903706 GO:1903708 GO:2000026 GO:2000514 GO:2000561
3560	interleukin 2 receptor subunit beta	IL2RB	Homo sapiens (human)	9606	asthma immunodeficiency 63 myasthenia gravis visceral leishmaniasis	DOID:0111997 DOID:2841 DOID:437 DOID:9146	B cell mediated immunity adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains adaptive immune response binding biological regulation biological_process cell surface receptor signaling pathway cell surface cellular anatomical entity cellular component assembly cellular component organization or biogenesis cellular component organization cellular process cellular_component coreceptor activity cytokine binding cytokine receptor activity cytokine-mediated signaling pathway cytoplasmic vesicle cytosol endosome external side of plasma membrane growth factor binding immune effector process immune receptor activity immune response immune system process immunoglobulin mediated immune response interleukin-15 receptor activity interleukin-15-mediated signaling pathway interleukin-2 binding interleukin-2 receptor activity interleukin-2 receptor complex interleukin-2-mediated signaling pathway intracellular membrane-bounded organelle intracellular organelle intracellular vesicle leukocyte mediated immunity lymphocyte mediated immunity membrane protein complex membrane-bounded organelle membrane molecular transducer activity molecular_function negative regulation of apoptotic process negative regulation of biological process negative regulation of cellular process negative regulation of programmed cell death organelle plasma membrane protein complex plasma membrane signaling receptor complex plasma membrane positive regulation of biological process positive regulation of cellular component organization positive regulation of cellular process positive regulation of endocytosis positive regulation of phagocytosis positive regulation of transport protein binding protein-containing complex assembly protein-containing complex organization protein-containing complex receptor complex regulation of apoptotic process regulation of biological process regulation of cellular component organization regulation of cellular process regulation of endocytosis regulation of localization regulation of phagocytosis regulation of programmed cell death regulation of transport regulation of vesicle-mediated transport response to stimulus side of membrane signal transduction signaling receptor activity transmembrane signaling receptor activity vesicle	GO:0002250 GO:0002252 GO:0002376 GO:0002443 GO:0002449 GO:0002460 GO:0003674 GO:0004888 GO:0004896 GO:0004911 GO:0005488 GO:0005515 GO:0005575 GO:0005768 GO:0005829 GO:0005886 GO:0005893 GO:0006955 GO:0007165 GO:0007166 GO:0008150 GO:0009897 GO:0009986 GO:0009987 GO:0015026 GO:0016020 GO:0016043 GO:0016064 GO:0019221 GO:0019724 GO:0019838 GO:0019955 GO:0019976 GO:0022607 GO:0030100 GO:0031410 GO:0031982 GO:0032879 GO:0032991 GO:0035723 GO:0038023 GO:0038110 GO:0042010 GO:0042981 GO:0043066 GO:0043067 GO:0043069 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043235 GO:0043933 GO:0045807 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0050764 GO:0050766 GO:0050789 GO:0050794 GO:0050896 GO:0051049 GO:0051050 GO:0051128 GO:0051130 GO:0060089 GO:0060627 GO:0065003 GO:0065007 GO:0071840 GO:0097708 GO:0098552 GO:0098796 GO:0098797 GO:0098802 GO:0110165 GO:0140375
3561	interleukin 2 receptor subunit gamma	IL2RG	Homo sapiens (human)	9606	X-linked severe combined immunodeficiency combined T cell and B cell immunodeficiency severe combined immunodeficiency	DOID:0060013 DOID:627 DOID:628	B cell activation B cell differentiation CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation CD4-positive, alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation T cell activation T cell differentiation in thymus T cell differentiation alpha-beta T cell activation alpha-beta T cell differentiation binding biological regulation biological_process biosynthetic process cell activation cell differentiation cell surface receptor signaling pathway cell surface cellular anatomical entity cellular biosynthetic process cellular developmental process cellular homeostasis cellular metabolic process cellular process cellular_component coreceptor activity cytokine binding cytokine receptor activity cytokine-mediated signaling pathway cytoplasmic vesicle cytosol developmental process endoplasmic reticulum endosome external side of plasma membrane gene expression growth factor binding homeostatic process immune receptor activity immune response immune system process interleukin-15 receptor activity interleukin-15-mediated signaling pathway interleukin-2 binding interleukin-2 receptor activity interleukin-2-mediated signaling pathway interleukin-4 receptor activity interleukin-4-mediated signaling pathway interleukin-7 receptor activity interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway intracellular membrane-bounded organelle intracellular organelle intracellular vesicle leukocyte activation leukocyte differentiation lymphocyte activation lymphocyte differentiation macromolecule biosynthetic process macromolecule metabolic process mature B cell differentiation membrane-bounded organelle membrane metabolic process molecular transducer activity molecular_function mononuclear cell differentiation multicellular organismal process nucleoplasm organelle organic substance biosynthetic process organic substance metabolic process plasma membrane positive regulation of B cell activation positive regulation of B cell differentiation positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of T cell activation positive regulation of T cell differentiation in thymus positive regulation of T cell differentiation positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell differentiation positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell development positive regulation of cell differentiation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular component organization positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of developmental process positive regulation of endocytosis positive regulation of gene expression positive regulation of hemopoiesis positive regulation of immune effector process positive regulation of immune system process positive regulation of immunoglobulin production positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte differentiation positive regulation of lymphocyte activation positive regulation of lymphocyte differentiation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of phagocytosis positive regulation of production of molecular mediator of immune response positive regulation of regulatory T cell differentiation positive regulation of transport protein binding protein-containing complex receptor complex regulation of B cell activation regulation of B cell differentiation regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulation of CD4-positive, alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell differentiation regulation of T cell activation regulation of T cell differentiation in thymus regulation of T cell differentiation regulation of alpha-beta T cell activation regulation of alpha-beta T cell differentiation regulation of biological process regulation of biosynthetic process regulation of cell activation regulation of cell adhesion regulation of cell development regulation of cell differentiation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of developmental process regulation of endocytosis regulation of gene expression regulation of hemopoiesis regulation of immune effector process regulation of immune system process regulation of immunoglobulin production regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of localization regulation of lymphocyte activation regulation of lymphocyte differentiation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal development regulation of multicellular organismal process regulation of phagocytosis regulation of production of molecular mediator of immune response regulation of regulatory T cell differentiation regulation of transport regulation of vesicle-mediated transport regulatory T cell differentiation response to stimulus side of membrane signal transduction signaling receptor activity transmembrane signaling receptor activity vesicle	GO:0001775 GO:0002335 GO:0002361 GO:0002376 GO:0002521 GO:0002637 GO:0002639 GO:0002682 GO:0002684 GO:0002694 GO:0002696 GO:0002697 GO:0002699 GO:0002700 GO:0002702 GO:0003674 GO:0004888 GO:0004896 GO:0004911 GO:0004913 GO:0004917 GO:0005488 GO:0005515 GO:0005575 GO:0005654 GO:0005768 GO:0005783 GO:0005829 GO:0005886 GO:0006955 GO:0007165 GO:0007166 GO:0008150 GO:0008152 GO:0009058 GO:0009059 GO:0009889 GO:0009891 GO:0009893 GO:0009897 GO:0009986 GO:0009987 GO:0010467 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0010720 GO:0015026 GO:0016020 GO:0019221 GO:0019222 GO:0019725 GO:0019838 GO:0019955 GO:0019976 GO:0022407 GO:0022409 GO:0030098 GO:0030100 GO:0030154 GO:0030155 GO:0030183 GO:0030217 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031410 GO:0031982 GO:0032501 GO:0032502 GO:0032829 GO:0032831 GO:0032879 GO:0032991 GO:0033077 GO:0033081 GO:0033089 GO:0035710 GO:0035723 GO:0035771 GO:0038023 GO:0038110 GO:0038111 GO:0038113 GO:0042010 GO:0042110 GO:0042113 GO:0042592 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043235 GO:0043367 GO:0043370 GO:0043372 GO:0044237 GO:0044249 GO:0045066 GO:0045321 GO:0045577 GO:0045579 GO:0045580 GO:0045582 GO:0045589 GO:0045591 GO:0045595 GO:0045597 GO:0045619 GO:0045621 GO:0045785 GO:0045807 GO:0046631 GO:0046632 GO:0046634 GO:0046635 GO:0046637 GO:0046638 GO:0046649 GO:0048518 GO:0048522 GO:0048869 GO:0050764 GO:0050766 GO:0050789 GO:0050793 GO:0050794 GO:0050863 GO:0050864 GO:0050865 GO:0050867 GO:0050870 GO:0050871 GO:0050896 GO:0051049 GO:0051050 GO:0051094 GO:0051128 GO:0051130 GO:0051239 GO:0051240 GO:0051249 GO:0051251 GO:0060089 GO:0060255 GO:0060284 GO:0060627 GO:0065007 GO:0071704 GO:0097708 GO:0098552 GO:0110165 GO:0140375 GO:1901576 GO:1902105 GO:1902107 GO:1903037 GO:1903039 GO:1903131 GO:1903706 GO:1903708 GO:2000026 GO:2000514 GO:2000516
3562	interleukin 3	IL3	Homo sapiens (human)	9606	Graves ophthalmopathy Graves' disease asthma rheumatoid arthritis	DOID:0081120 DOID:12361 DOID:2841 DOID:7148	anatomical structure development animal organ development binding biological regulation biological_process cell communication cell development cell surface receptor signaling pathway cell-cell signaling cellular anatomical entity cellular developmental process cellular process cellular_component cytokine activity cytokine receptor binding cytokine-mediated signaling pathway developmental process embryonic hemopoiesis embryonic organ development extracellular region extracellular space growth factor activity growth factor receptor binding hemopoiesis immune response immune system process interleukin-3 receptor binding interleukin-3-mediated signaling pathway molecular function activator activity molecular function regulator activity molecular_function nervous system development positive regulation of biological process positive regulation of cell population proliferation positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of nitrogen compound metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation protein binding receptor ligand activity receptor signaling pathway via STAT regulation of biological process regulation of cell population proliferation regulation of cellular metabolic process regulation of cellular process regulation of macromolecule metabolic process regulation of metabolic process regulation of nitrogen compound metabolic process regulation of peptidyl-tyrosine phosphorylation regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of primary metabolic process regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation response to stimulus signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity signaling system development	GO:0001932 GO:0001934 GO:0002376 GO:0003674 GO:0005102 GO:0005125 GO:0005126 GO:0005135 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0006955 GO:0007154 GO:0007165 GO:0007166 GO:0007267 GO:0007399 GO:0008083 GO:0008150 GO:0008284 GO:0009893 GO:0009987 GO:0010562 GO:0010604 GO:0019220 GO:0019221 GO:0019222 GO:0023052 GO:0030097 GO:0030545 GO:0030546 GO:0031323 GO:0031325 GO:0031399 GO:0031401 GO:0032502 GO:0035162 GO:0038156 GO:0042127 GO:0042325 GO:0042327 GO:0045937 GO:0048018 GO:0048468 GO:0048513 GO:0048518 GO:0048522 GO:0048568 GO:0048731 GO:0048856 GO:0048869 GO:0050730 GO:0050731 GO:0050789 GO:0050794 GO:0050896 GO:0051171 GO:0051173 GO:0051174 GO:0051246 GO:0051247 GO:0060255 GO:0065007 GO:0070851 GO:0080090 GO:0097696 GO:0098772 GO:0110165 GO:0140677
3563	interleukin 3 receptor subunit alpha	IL3RA	Homo sapiens (human)	9606			binding biological regulation biological_process cell surface receptor signaling pathway cellular anatomical entity cellular process cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to interleukin-3 cellular response to organic substance cellular response to stimulus cellular_component cytokine binding cytokine receptor activity cytokine-mediated signaling pathway external side of plasma membrane immune receptor activity interleukin-3 receptor activity interleukin-3-mediated signaling pathway membrane molecular transducer activity molecular_function plasma membrane positive regulation of biological process positive regulation of cell population proliferation positive regulation of cellular process protein binding protein-containing complex receptor complex regulation of biological process regulation of cell population proliferation regulation of cellular process response to chemical response to cytokine response to interleukin-3 response to organic substance response to stimulus side of membrane signal transduction signaling receptor activity transmembrane signaling receptor activity	GO:0003674 GO:0004888 GO:0004896 GO:0004912 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0007165 GO:0007166 GO:0008150 GO:0008284 GO:0009897 GO:0009987 GO:0010033 GO:0016020 GO:0019221 GO:0019955 GO:0032991 GO:0034097 GO:0036015 GO:0036016 GO:0038023 GO:0038156 GO:0042127 GO:0042221 GO:0043235 GO:0048518 GO:0048522 GO:0050789 GO:0050794 GO:0050896 GO:0051716 GO:0060089 GO:0065007 GO:0070887 GO:0071310 GO:0071345 GO:0098552 GO:0110165 GO:0140375
3565	interleukin 4	IL4	Homo sapiens (human)	9606	Alzheimer's disease Behcet's disease aspirin-induced respiratory disease asthma atopic dermatitis autoimmune hepatitis autoimmune thrombocytopenic purpura biliary tract benign neoplasm hepatitis B hepatitis C multiple sclerosis pancreatic cancer pancreatic ductal carcinoma temporal arteritis	DOID:0050625 DOID:0080822 DOID:10652 DOID:13241 DOID:13375 DOID:1793 DOID:1883 DOID:2043 DOID:2048 DOID:2377 DOID:2841 DOID:3310 DOID:3587 DOID:8924	B cell activation B cell differentiation T cell activation alcohol metabolic process binding biological regulation biological_process cell activation cell differentiation cell surface receptor signaling pathway cellular anatomical entity cellular developmental process cellular process cellular_component cholesterol metabolic process cytokine activity cytokine receptor binding cytokine-mediated signaling pathway defense response dendritic cell differentiation developmental process extracellular region extracellular space growth factor activity growth factor receptor binding immune response immune system process inflammatory response interleukin-4 receptor binding interleukin-4-mediated signaling pathway leukocyte activation leukocyte differentiation lipid metabolic process lymphocyte activation lymphocyte differentiation macrophage activation metabolic process molecular function activator activity molecular function regulator activity molecular_function mononuclear cell differentiation multicellular organismal process myeloid cell differentiation myeloid dendritic cell activation myeloid dendritic cell differentiation myeloid leukocyte activation myeloid leukocyte differentiation negative regulation of DNA-templated transcription negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of apoptotic process negative regulation of biological process negative regulation of biosynthetic process negative regulation of cell development negative regulation of cell differentiation negative regulation of cell killing negative regulation of cell migration negative regulation of cell motility negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of cellular response to growth factor stimulus negative regulation of cellular response to transforming growth factor beta stimulus negative regulation of complement-dependent cytotoxicity negative regulation of cytokine production negative regulation of defense response negative regulation of developmental process negative regulation of endothelial cell apoptotic process negative regulation of epithelial cell apoptotic process negative regulation of epithelial cell migration negative regulation of gene expression negative regulation of hemopoiesis negative regulation of immune system process negative regulation of inflammatory response negative regulation of leukocyte differentiation negative regulation of locomotion negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation negative regulation of neuroinflammatory response negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of osteoclast differentiation negative regulation of programmed cell death negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of transcription by RNA polymerase II negative regulation of tumor necrosis factor production negative regulation of tumor necrosis factor superfamily cytokine production neuroinflammatory response organic cyclic compound metabolic process organic hydroxy compound metabolic process organic substance metabolic process positive regulation of ATP biosynthetic process positive regulation of ATP metabolic process positive regulation of B cell activation positive regulation of B cell mediated immunity positive regulation of B cell proliferation positive regulation of DNA metabolic process positive regulation of DNA recombination positive regulation of DNA-templated transcription positive regulation of MHC class II biosynthetic process positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of T cell activation positive regulation of T cell cytokine production positive regulation of T cell differentiation positive regulation of T cell mediated immunity positive regulation of T cell proliferation positive regulation of T-helper 2 cell cytokine production positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response positive regulation of amyloid-beta clearance positive regulation of autophagy positive regulation of biological process positive regulation of biosynthetic process positive regulation of catabolic process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell development positive regulation of cell differentiation positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular catabolic process positive regulation of cellular component organization positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cellular respiration positive regulation of cold-induced thermogenesis positive regulation of cytokine production involved in immune response positive regulation of cytokine production positive regulation of developmental process positive regulation of endocytosis positive regulation of gene expression positive regulation of hemopoiesis positive regulation of immune effector process positive regulation of immune response positive regulation of immune system process positive regulation of immunoglobulin mediated immune response positive regulation of immunoglobulin production positive regulation of interleukin-10 production positive regulation of interleukin-13 production positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes positive regulation of isotype switching positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte differentiation positive regulation of leukocyte mediated immunity positive regulation of leukocyte proliferation positive regulation of locomotion positive regulation of lymphocyte activation positive regulation of lymphocyte differentiation positive regulation of lymphocyte mediated immunity positive regulation of lymphocyte proliferation positive regulation of macroautophagy positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of mononuclear cell proliferation positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of nucleotide biosynthetic process positive regulation of nucleotide metabolic process positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of production of molecular mediator of immune response positive regulation of purine nucleotide biosynthetic process positive regulation of purine nucleotide metabolic process positive regulation of receptor-mediated endocytosis positive regulation of response to stimulus positive regulation of small molecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of transport positive regulation of type 2 immune response primary metabolic process protein binding receptor ligand activity receptor signaling pathway via JAK-STAT receptor signaling pathway via STAT regulation of ATP biosynthetic process regulation of ATP metabolic process regulation of B cell activation regulation of B cell mediated immunity regulation of B cell proliferation regulation of DNA metabolic process regulation of DNA recombination regulation of DNA-templated transcription regulation of MHC class II biosynthetic process regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of T cell activation regulation of T cell cytokine production regulation of T cell differentiation regulation of T cell mediated immunity regulation of T cell proliferation regulation of T-helper 2 cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of amyloid-beta clearance regulation of apoptotic process regulation of autophagy regulation of biological process regulation of biosynthetic process regulation of catabolic process regulation of cell activation regulation of cell adhesion regulation of cell development regulation of cell differentiation regulation of cell killing regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular catabolic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cellular respiration regulation of cellular response to growth factor stimulus regulation of cellular response to transforming growth factor beta stimulus regulation of cold-induced thermogenesis regulation of complement-dependent cytotoxicity regulation of cytokine production involved in immune response regulation of cytokine production regulation of defense response regulation of developmental process regulation of endocytosis regulation of endothelial cell apoptotic process regulation of epithelial cell apoptotic process regulation of epithelial cell migration regulation of gene expression regulation of generation of precursor metabolites and energy regulation of hemopoiesis regulation of immune effector process regulation of immune response regulation of immune system process regulation of immunoglobulin mediated immune response regulation of immunoglobulin production regulation of inflammatory response regulation of interleukin-10 production regulation of interleukin-13 production regulation of isotype switching to IgE isotypes regulation of isotype switching to IgG isotypes regulation of isotype switching regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of leukocyte mediated immunity regulation of leukocyte proliferation regulation of localization regulation of locomotion regulation of lymphocyte activation regulation of lymphocyte differentiation regulation of lymphocyte mediated immunity regulation of lymphocyte proliferation regulation of macroautophagy regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of mononuclear cell proliferation regulation of multicellular organismal development regulation of multicellular organismal process regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation regulation of neuroinflammatory response regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of nucleotide biosynthetic process regulation of nucleotide metabolic process regulation of osteoclast differentiation regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of primary metabolic process regulation of production of molecular mediator of immune response regulation of programmed cell death regulation of purine nucleotide biosynthetic process regulation of purine nucleotide metabolic process regulation of receptor-mediated endocytosis regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of small molecule metabolic process regulation of transcription by RNA polymerase II regulation of transport regulation of tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of type 2 immune response regulation of vesicle-mediated transport response to stimulus response to stress secondary alcohol metabolic process signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity small molecule metabolic process steroid metabolic process sterol metabolic process type 2 immune response	GO:0000018 GO:0000122 GO:0001773 GO:0001775 GO:0001817 GO:0001818 GO:0001819 GO:0002274 GO:0002376 GO:0002521 GO:0002573 GO:0002637 GO:0002639 GO:0002682 GO:0002683 GO:0002684 GO:0002694 GO:0002696 GO:0002697 GO:0002699 GO:0002700 GO:0002702 GO:0002703 GO:0002705 GO:0002706 GO:0002708 GO:0002709 GO:0002711 GO:0002712 GO:0002714 GO:0002718 GO:0002720 GO:0002724 GO:0002726 GO:0002761 GO:0002762 GO:0002819 GO:0002821 GO:0002822 GO:0002824 GO:0002828 GO:0002830 GO:0002889 GO:0002891 GO:0003674 GO:0005102 GO:0005125 GO:0005126 GO:0005136 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0006066 GO:0006140 GO:0006355 GO:0006357 GO:0006629 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0007165 GO:0007166 GO:0007259 GO:0008083 GO:0008150 GO:0008152 GO:0008202 GO:0008203 GO:0008284 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009894 GO:0009896 GO:0009987 GO:0010468 GO:0010506 GO:0010508 GO:0010556 GO:0010557 GO:0010558 GO:0010562 GO:0010604 GO:0010605 GO:0010628 GO:0010629 GO:0010632 GO:0010633 GO:0010720 GO:0010721 GO:0016125 GO:0016239 GO:0016241 GO:0019219 GO:0019220 GO:0019221 GO:0019222 GO:0022407 GO:0022409 GO:0030098 GO:0030099 GO:0030100 GO:0030154 GO:0030155 GO:0030183 GO:0030334 GO:0030335 GO:0030336 GO:0030545 GO:0030546 GO:0030808 GO:0030810 GO:0030888 GO:0030890 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031329 GO:0031331 GO:0031341 GO:0031342 GO:0031347 GO:0031348 GO:0032101 GO:0032102 GO:0032501 GO:0032502 GO:0032653 GO:0032656 GO:0032680 GO:0032720 GO:0032733 GO:0032736 GO:0032879 GO:0032944 GO:0032946 GO:0035771 GO:0040012 GO:0040013 GO:0040017 GO:0042092 GO:0042102 GO:0042110 GO:0042113 GO:0042116 GO:0042127 GO:0042129 GO:0042325 GO:0042981 GO:0043011 GO:0043066 GO:0043067 GO:0043069 GO:0043457 GO:0043467 GO:0044238 GO:0044281 GO:0045191 GO:0045321 GO:0045346 GO:0045348 GO:0045580 GO:0045582 GO:0045595 GO:0045596 GO:0045597 GO:0045619 GO:0045621 GO:0045637 GO:0045638 GO:0045670 GO:0045671 GO:0045785 GO:0045807 GO:0045830 GO:0045892 GO:0045893 GO:0045911 GO:0045934 GO:0045935 GO:0045937 GO:0045944 GO:0045981 GO:0046649 GO:0048018 GO:0048259 GO:0048260 GO:0048293 GO:0048295 GO:0048302 GO:0048304 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048869 GO:0050670 GO:0050671 GO:0050727 GO:0050728 GO:0050776 GO:0050778 GO:0050789 GO:0050793 GO:0050794 GO:0050863 GO:0050864 GO:0050865 GO:0050867 GO:0050870 GO:0050871 GO:0050896 GO:0051049 GO:0051050 GO:0051052 GO:0051054 GO:0051093 GO:0051094 GO:0051128 GO:0051130 GO:0051171 GO:0051172 GO:0051173 GO:0051174 GO:0051239 GO:0051240 GO:0051241 GO:0051249 GO:0051251 GO:0051252 GO:0051253 GO:0051254 GO:0060255 GO:0060284 GO:0060627 GO:0062012 GO:0062013 GO:0065007 GO:0070663 GO:0070665 GO:0070851 GO:0071704 GO:0080090 GO:0080134 GO:0090287 GO:0090288 GO:0097028 GO:0097696 GO:0098772 GO:0110165 GO:0120161 GO:0120162 GO:0140677 GO:0150076 GO:0150077 GO:0150079 GO:1900221 GO:1900223 GO:1900371 GO:1900373 GO:1900542 GO:1900544 GO:1901360 GO:1901615 GO:1901857 GO:1902105 GO:1902106 GO:1902107 GO:1902652 GO:1902679 GO:1902680 GO:1903037 GO:1903039 GO:1903131 GO:1903555 GO:1903556 GO:1903578 GO:1903580 GO:1903659 GO:1903660 GO:1903706 GO:1903707 GO:1903708 GO:1903844 GO:1903845 GO:1904035 GO:1904036 GO:2000026 GO:2000145 GO:2000146 GO:2000147 GO:2000351 GO:2000352 GO:2000551 GO:2000553 GO:2001141 GO:2001169 GO:2001171
3566	interleukin 4 receptor	IL4R	Homo sapiens (human)	9606	acne allergic conjunctivitis asthma atopic dermatitis esophagitis interstitial lung disease multiple myeloma multiple sclerosis primary progressive multiple sclerosis renal cell carcinoma renal tuberculosis rheumatoid arthritis rhinitis	DOID:0050784 DOID:11204 DOID:11963 DOID:2377 DOID:2841 DOID:3082 DOID:3310 DOID:4450 DOID:4483 DOID:6543 DOID:7148 DOID:9538 DOID:9733	B cell mediated immunity CD4-positive, alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation involved in immune response CD4-positive, alpha-beta T cell differentiation T cell activation involved in immune response T cell activation T cell differentiation involved in immune response T cell differentiation T-helper 1 cell differentiation T-helper 2 cell differentiation T-helper cell differentiation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains adaptive immune response alpha-beta T cell activation involved in immune response alpha-beta T cell activation alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation binding biological process involved in interspecies interaction between organisms biological regulation biological_process cell activation involved in immune response cell activation cell differentiation cell surface receptor signaling pathway cellular anatomical entity cellular developmental process cellular process cellular_component centriolar satellite cytokine receptor activity cytokine-mediated signaling pathway defense response to other organism defense response to protozoan defense response developmental process external side of plasma membrane extracellular region immune effector process immune receptor activity immune response immune system process immunoglobulin mediated immune response interleukin-4 receptor activity interleukin-4-mediated signaling pathway leukocyte activation involved in immune response leukocyte activation leukocyte differentiation leukocyte mediated immunity lymphocyte activation involved in immune response lymphocyte activation lymphocyte differentiation lymphocyte mediated immunity membrane molecular transducer activity molecular_function mononuclear cell differentiation multicellular organismal process negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of T cell activation negative regulation of T cell differentiation negative regulation of T-helper 1 cell differentiation negative regulation of T-helper 1 type immune response negative regulation of T-helper cell differentiation negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of adaptive immune response negative regulation of alpha-beta T cell activation negative regulation of alpha-beta T cell differentiation negative regulation of biological process negative regulation of cell activation negative regulation of cell adhesion negative regulation of cell development negative regulation of cell differentiation negative regulation of cell-cell adhesion negative regulation of cellular process negative regulation of developmental process negative regulation of hemopoiesis negative regulation of immune effector process negative regulation of immune response negative regulation of immune system process negative regulation of leukocyte activation negative regulation of leukocyte cell-cell adhesion negative regulation of leukocyte differentiation negative regulation of lymphocyte activation negative regulation of lymphocyte differentiation negative regulation of multicellular organismal process negative regulation of response to stimulus nucleoplasm plasma membrane positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of T cell activation positive regulation of T cell differentiation positive regulation of T-helper 2 cell differentiation positive regulation of T-helper cell differentiation positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell differentiation positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell development positive regulation of cell differentiation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular component organization positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of chemokine production positive regulation of cold-induced thermogenesis positive regulation of cytokine production positive regulation of developmental process positive regulation of exocytosis positive regulation of gene expression positive regulation of hemopoiesis positive regulation of immune effector process positive regulation of immune response positive regulation of immune system process positive regulation of immunoglobulin production positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte degranulation positive regulation of leukocyte differentiation positive regulation of lymphocyte activation positive regulation of lymphocyte differentiation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of macrophage activation positive regulation of mast cell degranulation positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of myoblast fusion positive regulation of production of molecular mediator of immune response positive regulation of regulated secretory pathway positive regulation of response to stimulus positive regulation of secretion by cell positive regulation of secretion positive regulation of syncytium formation by plasma membrane fusion positive regulation of transport positive regulation of type 2 immune response production of molecular mediator involved in inflammatory response protein binding protein-containing complex receptor complex regulation of CD4-positive, alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell differentiation regulation of T cell activation regulation of T cell differentiation regulation of T-helper 1 cell differentiation regulation of T-helper 1 type immune response regulation of T-helper 2 cell differentiation regulation of T-helper cell differentiation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of alpha-beta T cell activation regulation of alpha-beta T cell differentiation regulation of biological process regulation of biosynthetic process regulation of cell activation regulation of cell adhesion regulation of cell development regulation of cell differentiation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of chemokine production regulation of cold-induced thermogenesis regulation of cytokine production regulation of developmental process regulation of exocytosis regulation of gene expression regulation of hemopoiesis regulation of immune effector process regulation of immune response regulation of immune system process regulation of immunoglobulin production regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of leukocyte degranulation regulation of leukocyte differentiation regulation of leukocyte mediated immunity regulation of localization regulation of lymphocyte activation regulation of lymphocyte differentiation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of macrophage activation regulation of mast cell degranulation regulation of metabolic process regulation of multicellular organismal development regulation of multicellular organismal process regulation of myeloid leukocyte mediated immunity regulation of myoblast fusion regulation of production of molecular mediator of immune response regulation of regulated secretory pathway regulation of response to stimulus regulation of secretion by cell regulation of secretion regulation of syncytium formation by plasma membrane fusion regulation of transport regulation of type 2 immune response regulation of vesicle-mediated transport response to biotic stimulus response to external biotic stimulus response to external stimulus response to other organism response to protozoan response to stimulus response to stress side of membrane signal transduction signaling receptor activity transmembrane signaling receptor activity	GO:0001562 GO:0001775 GO:0001817 GO:0001819 GO:0002250 GO:0002252 GO:0002263 GO:0002285 GO:0002286 GO:0002287 GO:0002292 GO:0002293 GO:0002294 GO:0002366 GO:0002376 GO:0002443 GO:0002449 GO:0002460 GO:0002521 GO:0002532 GO:0002637 GO:0002639 GO:0002682 GO:0002683 GO:0002684 GO:0002694 GO:0002695 GO:0002696 GO:0002697 GO:0002698 GO:0002699 GO:0002700 GO:0002702 GO:0002703 GO:0002819 GO:0002820 GO:0002822 GO:0002823 GO:0002825 GO:0002826 GO:0002828 GO:0002830 GO:0002886 GO:0003674 GO:0004888 GO:0004896 GO:0004913 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005654 GO:0005886 GO:0006950 GO:0006952 GO:0006955 GO:0007162 GO:0007165 GO:0007166 GO:0008150 GO:0009605 GO:0009607 GO:0009889 GO:0009891 GO:0009893 GO:0009897 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0010720 GO:0010721 GO:0016020 GO:0016064 GO:0017157 GO:0019221 GO:0019222 GO:0019724 GO:0022407 GO:0022408 GO:0022409 GO:0030098 GO:0030154 GO:0030155 GO:0030217 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0032501 GO:0032502 GO:0032642 GO:0032722 GO:0032879 GO:0032991 GO:0034451 GO:0035710 GO:0035771 GO:0038023 GO:0042093 GO:0042110 GO:0042832 GO:0043030 GO:0043032 GO:0043207 GO:0043235 GO:0043300 GO:0043302 GO:0043304 GO:0043306 GO:0043367 GO:0043370 GO:0043371 GO:0043372 GO:0044419 GO:0045063 GO:0045064 GO:0045321 GO:0045580 GO:0045581 GO:0045582 GO:0045595 GO:0045596 GO:0045597 GO:0045619 GO:0045620 GO:0045621 GO:0045622 GO:0045623 GO:0045624 GO:0045625 GO:0045626 GO:0045628 GO:0045630 GO:0045785 GO:0045921 GO:0046631 GO:0046632 GO:0046634 GO:0046635 GO:0046636 GO:0046637 GO:0046638 GO:0046639 GO:0046649 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048869 GO:0050776 GO:0050777 GO:0050778 GO:0050789 GO:0050793 GO:0050794 GO:0050863 GO:0050865 GO:0050866 GO:0050867 GO:0050868 GO:0050870 GO:0050896 GO:0051046 GO:0051047 GO:0051049 GO:0051050 GO:0051093 GO:0051094 GO:0051128 GO:0051130 GO:0051239 GO:0051240 GO:0051241 GO:0051249 GO:0051250 GO:0051251 GO:0051707 GO:0060089 GO:0060142 GO:0060143 GO:0060255 GO:0060284 GO:0060627 GO:0065007 GO:0098542 GO:0098552 GO:0110165 GO:0120161 GO:0120162 GO:0140375 GO:1901739 GO:1901741 GO:1902105 GO:1902106 GO:1902107 GO:1903037 GO:1903038 GO:1903039 GO:1903131 GO:1903305 GO:1903307 GO:1903530 GO:1903532 GO:1903706 GO:1903707 GO:1903708 GO:2000026 GO:2000514 GO:2000515 GO:2000516
3567	interleukin 5	IL5	Homo sapiens (human)	9606	asthma stomach cancer	DOID:10534 DOID:2841	binding biological regulation biological_process cell surface receptor signaling pathway cellular anatomical entity cellular process cellular_component cytokine activity cytokine receptor binding cytokine-mediated signaling pathway defense response extracellular region extracellular space growth factor activity growth factor receptor binding immune response immune system process inflammatory response interleukin-5 receptor binding interleukin-5-mediated signaling pathway molecular function activator activity molecular function regulator activity molecular_function positive regulation of B cell activation positive regulation of B cell proliferation positive regulation of DNA-binding transcription factor activity positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell activation positive regulation of cell communication positive regulation of cell development positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of cellular biosynthetic process positive regulation of cellular component biogenesis positive regulation of cellular component organization positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of developmental process positive regulation of eosinophil differentiation positive regulation of gene expression positive regulation of granulocyte differentiation positive regulation of hemopoiesis positive regulation of immune effector process positive regulation of immune system process positive regulation of immunoglobulin production positive regulation of leukocyte activation positive regulation of leukocyte differentiation positive regulation of leukocyte proliferation positive regulation of lymphocyte activation positive regulation of lymphocyte proliferation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of mononuclear cell proliferation positive regulation of multicellular organismal process positive regulation of myeloid cell differentiation positive regulation of myeloid leukocyte differentiation positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of organelle assembly positive regulation of organelle organization positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of podosome assembly positive regulation of production of molecular mediator of immune response positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of protein-containing complex assembly positive regulation of receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via STAT positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling protein binding receptor ligand activity regulation of B cell activation regulation of B cell proliferation regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of biological process regulation of biosynthetic process regulation of cell activation regulation of cell communication regulation of cell development regulation of cell differentiation regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular component biogenesis regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of developmental process regulation of eosinophil differentiation regulation of gene expression regulation of granulocyte differentiation regulation of hemopoiesis regulation of immune effector process regulation of immune system process regulation of immunoglobulin production regulation of leukocyte activation regulation of leukocyte differentiation regulation of leukocyte proliferation regulation of lymphocyte activation regulation of lymphocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of mononuclear cell proliferation regulation of multicellular organismal development regulation of multicellular organismal process regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of organelle assembly regulation of organelle organization regulation of peptidyl-tyrosine phosphorylation regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of podosome assembly regulation of primary metabolic process regulation of production of molecular mediator of immune response regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of protein-containing complex assembly regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT regulation of response to stimulus regulation of signal transduction regulation of signaling response to stimulus response to stress signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity	GO:0001932 GO:0001934 GO:0002376 GO:0002637 GO:0002639 GO:0002682 GO:0002684 GO:0002694 GO:0002696 GO:0002697 GO:0002699 GO:0002700 GO:0002702 GO:0002761 GO:0002763 GO:0003674 GO:0005102 GO:0005125 GO:0005126 GO:0005137 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0006355 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0007165 GO:0007166 GO:0008083 GO:0008150 GO:0008284 GO:0009889 GO:0009891 GO:0009893 GO:0009966 GO:0009967 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010562 GO:0010604 GO:0010628 GO:0010638 GO:0010646 GO:0010647 GO:0010720 GO:0019219 GO:0019220 GO:0019221 GO:0019222 GO:0023051 GO:0023056 GO:0030545 GO:0030546 GO:0030852 GO:0030854 GO:0030888 GO:0030890 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031334 GO:0031399 GO:0031401 GO:0032944 GO:0032946 GO:0033043 GO:0038043 GO:0042127 GO:0042325 GO:0042327 GO:0043254 GO:0044087 GO:0044089 GO:0044093 GO:0045595 GO:0045597 GO:0045637 GO:0045639 GO:0045643 GO:0045645 GO:0045893 GO:0045935 GO:0045937 GO:0046425 GO:0046427 GO:0048018 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0050670 GO:0050671 GO:0050730 GO:0050731 GO:0050789 GO:0050793 GO:0050794 GO:0050864 GO:0050865 GO:0050867 GO:0050871 GO:0050896 GO:0051090 GO:0051091 GO:0051094 GO:0051128 GO:0051130 GO:0051171 GO:0051173 GO:0051174 GO:0051239 GO:0051240 GO:0051246 GO:0051247 GO:0051249 GO:0051251 GO:0051252 GO:0051254 GO:0060255 GO:0060284 GO:0065007 GO:0065009 GO:0070663 GO:0070665 GO:0070851 GO:0071801 GO:0071803 GO:0080090 GO:0098772 GO:0110165 GO:0140677 GO:1902105 GO:1902107 GO:1902115 GO:1902117 GO:1902680 GO:1903706 GO:1903708 GO:1904892 GO:1904894 GO:2000026 GO:2001141
3568	interleukin 5 receptor subunit alpha	IL5RA	Homo sapiens (human)	9606	asthma	DOID:2841	binding biological regulation biological_process cell surface receptor signaling pathway cellular anatomical entity cellular process cellular_component cytokine binding cytokine receptor activity cytokine-mediated signaling pathway defense response external side of plasma membrane extracellular space immune receptor activity immune response immune system process inflammatory response to antigenic stimulus inflammatory response interleukin-5 receptor activity interleukin-5-mediated signaling pathway membrane molecular transducer activity molecular_function plasma membrane positive regulation of biological process positive regulation of cell population proliferation positive regulation of cellular process positive regulation of leukocyte proliferation protein binding protein-containing complex receptor complex regulation of biological process regulation of biosynthetic process regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cytokine production regulation of gene expression regulation of interleukin-5 production regulation of leukocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process response to stimulus response to stress side of membrane signal transduction signaling receptor activity transmembrane signaling receptor activity	GO:0001817 GO:0002376 GO:0002437 GO:0003674 GO:0004888 GO:0004896 GO:0004914 GO:0005488 GO:0005515 GO:0005575 GO:0005615 GO:0005886 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0007165 GO:0007166 GO:0008150 GO:0008284 GO:0009889 GO:0009897 GO:0009987 GO:0010468 GO:0010556 GO:0016020 GO:0019221 GO:0019222 GO:0019955 GO:0031323 GO:0031326 GO:0032674 GO:0032991 GO:0038023 GO:0038043 GO:0042127 GO:0043235 GO:0048518 GO:0048522 GO:0050789 GO:0050794 GO:0050896 GO:0051239 GO:0060089 GO:0060255 GO:0065007 GO:0070663 GO:0070665 GO:0098552 GO:0110165 GO:0140375
3569	interleukin 6	IL6	Homo sapiens (human)	9606	Crohn's disease Graves' disease Hodgkin's lymphoma Huntington's disease Kaposi's sarcoma Sjogren's syndrome acute myeloid leukemia aggressive periodontitis arteriovenous malformations of the brain breast cancer celiac disease colorectal cancer depressive disorder diabetes mellitus diabetic retinopathy dry eye syndrome gestational diabetes glucosephosphate dehydrogenase deficiency hepatitis B hepatitis C hepatocellular carcinoma hyperglycemia hyperinsulinism hypertension intracranial aneurysm keratitis lymphoplasmacytic lymphoma major depressive disorder metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease multiple sclerosis obesity otitis media periodontal disease periodontitis peripheral vascular disease prediabetes syndrome quadriplegia rectum cancer retinal artery occlusion stomach cancer type 1 diabetes mellitus type 2 diabetes mellitus uveitis	DOID:0060688 DOID:0060901 DOID:0080208 DOID:0080547 DOID:10140 DOID:10534 DOID:10608 DOID:10754 DOID:10763 DOID:10941 DOID:11714 DOID:11716 DOID:12361 DOID:12835 DOID:12858 DOID:12894 DOID:13141 DOID:1470 DOID:1474 DOID:1596 DOID:1612 DOID:1883 DOID:1993 DOID:2018 DOID:2043 DOID:2377 DOID:2862 DOID:3388 DOID:341 DOID:4195 DOID:4677 DOID:684 DOID:824 DOID:8483 DOID:8567 DOID:8632 DOID:8778 DOID:8947 DOID:9119 DOID:9256 DOID:9351 DOID:9352 DOID:9744 DOID:9970	B cell activation involved in immune response B cell activation B cell differentiation CD4-positive or CD8-positive, alpha-beta T cell lineage commitment CD4-positive, alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell lineage commitment T cell activation involved in immune response T cell activation T cell differentiation involved in immune response T cell differentiation T cell lineage commitment T follicular helper cell differentiation T-helper 17 cell lineage commitment T-helper cell differentiation T-helper cell lineage commitment acute inflammatory response acute-phase response alpha-beta T cell activation involved in immune response alpha-beta T cell activation alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation alpha-beta T cell lineage commitment amide transport anatomical structure development anatomical structure homeostasis animal organ development animal organ regeneration apoptotic process binding biological process involved in interspecies interaction between organisms biological regulation biological_process biosynthetic process carbohydrate homeostasis cell activation involved in immune response cell activation cell chemotaxis cell death cell differentiation cell fate commitment cell migration cell motility cell population proliferation cell projection organization cell surface receptor signaling pathway cellular anatomical entity cellular biosynthetic process cellular component organization or biogenesis cellular component organization cellular developmental process cellular homeostasis cellular metabolic process cellular process cellular response to biotic stimulus cellular response to chemical stimulus cellular response to chemical stress cellular response to hydrogen peroxide cellular response to lipid cellular response to lipopolysaccharide cellular response to molecule of bacterial origin cellular response to organic substance cellular response to oxidative stress cellular response to oxygen-containing compound cellular response to reactive oxygen species cellular response to stimulus cellular response to stress cellular response to virus cellular_component chemical homeostasis chemotaxis cytokine activity cytokine production cytokine receptor binding cytokine-mediated signaling pathway defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to bacterium defense response to other organism defense response to symbiont defense response to virus defense response developmental process endocrine pancreas development endoplasmic reticulum lumen epithelial cell proliferation involved in liver morphogenesis epithelial cell proliferation establishment of localization export from cell extracellular region extracellular space gene expression germinal center B cell differentiation gland development glucagon secretion glucose homeostasis growth factor activity growth factor receptor binding hepatic immune response hepatocyte proliferation homeostatic process hormone secretion hormone transport humoral immune response identical protein binding immune effector process immune response immune system process inflammatory cell apoptotic process inflammatory response to wounding inflammatory response interleukin-6 receptor binding interleukin-6 receptor complex interleukin-6-mediated signaling pathway intracellular organelle lumen leukocyte activation involved in immune response leukocyte activation leukocyte apoptotic process leukocyte chemotaxis leukocyte differentiation leukocyte mediated immunity leukocyte migration liver development liver regeneration localization locomotion lymphocyte activation involved in immune response lymphocyte activation lymphocyte differentiation macromolecule biosynthetic process macromolecule metabolic process maintenance of blood-brain barrier mature B cell differentiation involved in immune response mature B cell differentiation membrane protein complex membrane-enclosed lumen metabolic process molecular function activator activity molecular function regulator activity molecular_function monocyte chemotaxis mononuclear cell differentiation mononuclear cell migration multicellular organismal process multicellular organismal-level homeostasis myeloid cell apoptotic process myeloid leukocyte mediated immunity myeloid leukocyte migration negative regulation of RNA metabolic process negative regulation of apoptotic process negative regulation of biological process negative regulation of biosynthetic process negative regulation of bone remodeling negative regulation of bone resorption negative regulation of cell communication negative regulation of cell development negative regulation of cell differentiation negative regulation of cell population proliferation negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of chemokine production negative regulation of collagen biosynthetic process negative regulation of collagen metabolic process negative regulation of cytokine production negative regulation of cytokine-mediated signaling pathway negative regulation of developmental process negative regulation of fat cell differentiation negative regulation of gene expression negative regulation of gene silencing by regulatory ncRNA negative regulation of interleukin-1-mediated signaling pathway negative regulation of lipid localization negative regulation of lipid storage negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of miRNA processing negative regulation of miRNA-mediated gene silencing negative regulation of multicellular organismal process negative regulation of nervous system development negative regulation of neurogenesis negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of post-transcriptional gene silencing by regulatory ncRNA negative regulation of post-transcriptional gene silencing negative regulation of primary miRNA processing negative regulation of programmed cell death negative regulation of response to cytokine stimulus negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of tissue remodeling neuron cellular homeostasis neuron projection development neutrophil apoptotic process neutrophil mediated immunity nitrogen compound transport organ or tissue specific immune response organelle lumen organic substance biosynthetic process organic substance metabolic process organic substance transport peptide hormone secretion peptide secretion peptide transport plasma membrane bounded cell projection organization plasma membrane protein complex plasma membrane signaling receptor complex platelet activation positive regulation of B cell activation positive regulation of DNA catabolic process positive regulation of DNA metabolic process positive regulation of DNA-binding transcription factor activity positive regulation of DNA-templated transcription positive regulation of MAPK cascade positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of T cell activation positive regulation of T cell cytokine production positive regulation of T cell mediated immunity positive regulation of T cell proliferation positive regulation of T-helper 2 cell cytokine production positive regulation of acute inflammatory response positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response positive regulation of amide metabolic process positive regulation of apoptotic DNA fragmentation positive regulation of apoptotic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of catabolic process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell communication positive regulation of cell development positive regulation of cell differentiation positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular catabolic process positive regulation of cellular component organization positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of chemokine production positive regulation of chemotaxis positive regulation of cytokine production involved in immune response positive regulation of cytokine production involved in inflammatory response positive regulation of cytokine production positive regulation of defense response positive regulation of developmental process positive regulation of epithelial cell apoptotic process positive regulation of epithelial to mesenchymal transition positive regulation of extracellular matrix disassembly positive regulation of extracellular matrix organization positive regulation of gene expression positive regulation of glial cell proliferation positive regulation of gliogenesis positive regulation of homotypic cell-cell adhesion positive regulation of immune effector process positive regulation of immune response positive regulation of immune system process positive regulation of immunoglobulin production positive regulation of inflammatory response positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-17 production positive regulation of interleukin-21 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of intracellular signal transduction positive regulation of leukocyte activation positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte chemotaxis positive regulation of leukocyte mediated immunity positive regulation of leukocyte migration positive regulation of leukocyte proliferation positive regulation of locomotion positive regulation of lymphocyte activation positive regulation of lymphocyte mediated immunity positive regulation of lymphocyte proliferation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of miRNA metabolic process positive regulation of miRNA transcription positive regulation of molecular function positive regulation of mononuclear cell proliferation positive regulation of multicellular organismal process positive regulation of nervous system development positive regulation of neurogenesis positive regulation of neuroinflammatory response positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of osteoblast differentiation positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of platelet aggregation positive regulation of production of molecular mediator of immune response positive regulation of programmed cell death positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via STAT positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of smooth muscle cell proliferation positive regulation of transcription by RNA polymerase II positive regulation of translation positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of type 2 immune response positive regulation of type B pancreatic cell apoptotic process positive regulation of vascular endothelial growth factor production post-transcriptional regulation of gene expression programmed cell death protein binding protein-containing complex receptor complex receptor ligand activity receptor signaling pathway via JAK-STAT receptor signaling pathway via STAT regeneration regulation of B cell activation regulation of DNA catabolic process regulation of DNA metabolic process regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of MAPK cascade regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of T cell activation regulation of T cell cytokine production regulation of T cell mediated immunity regulation of T cell proliferation regulation of T-helper 2 cell cytokine production regulation of acute inflammatory response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of amide metabolic process regulation of anatomical structure morphogenesis regulation of angiogenesis regulation of apoptotic DNA fragmentation regulation of apoptotic process regulation of astrocyte activation regulation of astrocyte differentiation regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of bone remodeling regulation of bone resorption regulation of catabolic process regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell development regulation of cell differentiation regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular catabolic process regulation of cellular component organization regulation of cellular localization regulation of cellular metabolic process regulation of cellular process regulation of chemokine production regulation of chemotaxis regulation of collagen biosynthetic process regulation of collagen metabolic process regulation of cytokine production involved in immune response regulation of cytokine production involved in inflammatory response regulation of cytokine production regulation of cytokine-mediated signaling pathway regulation of defense response regulation of developmental process regulation of epithelial cell apoptotic process regulation of epithelial to mesenchymal transition regulation of establishment of protein localization regulation of extracellular matrix disassembly regulation of extracellular matrix organization regulation of fat cell differentiation regulation of gene expression regulation of gene silencing by regulatory ncRNA regulation of glial cell differentiation regulation of glial cell proliferation regulation of gliogenesis regulation of glucagon secretion regulation of homotypic cell-cell adhesion regulation of hormone levels regulation of hormone secretion regulation of immune effector process regulation of immune response regulation of immune system process regulation of immunoglobulin production regulation of inflammatory response regulation of insulin secretion regulation of interleukin-1 beta production regulation of interleukin-1 production regulation of interleukin-1-mediated signaling pathway regulation of interleukin-10 production regulation of interleukin-17 production regulation of interleukin-21 production regulation of interleukin-6 production regulation of interleukin-8 production regulation of intracellular signal transduction regulation of leukocyte activation regulation of leukocyte adhesion to vascular endothelial cell regulation of leukocyte cell-cell adhesion regulation of leukocyte chemotaxis regulation of leukocyte mediated immunity regulation of leukocyte migration regulation of leukocyte proliferation regulation of lipid localization regulation of lipid storage regulation of localization regulation of locomotion regulation of lymphocyte activation regulation of lymphocyte mediated immunity regulation of lymphocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of macrophage activation regulation of metabolic process regulation of miRNA metabolic process regulation of miRNA processing regulation of miRNA transcription regulation of miRNA-mediated gene silencing regulation of microglial cell activation regulation of molecular function regulation of mononuclear cell proliferation regulation of multicellular organismal development regulation of multicellular organismal process regulation of ncRNA transcription regulation of nervous system development regulation of neurogenesis regulation of neuroinflammatory response regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of osteoblast differentiation regulation of peptide hormone secretion regulation of peptide secretion regulation of peptide transport regulation of peptidyl-serine phosphorylation regulation of peptidyl-tyrosine phosphorylation regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of platelet activation regulation of platelet aggregation regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of post-transcriptional gene silencing regulation of primary metabolic process regulation of primary miRNA processing regulation of production of molecular mediator of immune response regulation of programmed cell death regulation of protein localization regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of protein secretion regulation of protein transport regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT regulation of regulatory ncRNA processing regulation of response to cytokine stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling regulation of smooth muscle cell proliferation regulation of tissue remodeling regulation of transcription by RNA polymerase II regulation of translation regulation of transport regulation of tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of type 2 immune response regulation of type B pancreatic cell apoptotic process regulation of vascular endothelial growth factor production regulation of vasculature development response to activity response to bacterium response to biotic stimulus response to chemical response to corticosteroid response to endogenous stimulus response to external biotic stimulus response to external stimulus response to glucocorticoid response to hormone response to hydrogen peroxide response to inorganic substance response to lipid response to lipopolysaccharide response to molecule of bacterial origin response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to other organism response to oxidative stress response to oxygen-containing compound response to peptidoglycan response to reactive oxygen species response to steroid hormone response to stimulus response to stress response to virus response to wounding secretion by cell secretion signal release signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity taxis tissue homeostasis transport vascular endothelial growth factor production	GO:0000302 GO:0001775 GO:0001781 GO:0001816 GO:0001817 GO:0001818 GO:0001819 GO:0001889 GO:0001894 GO:0001932 GO:0001934 GO:0001959 GO:0001960 GO:0002237 GO:0002251 GO:0002252 GO:0002263 GO:0002285 GO:0002286 GO:0002287 GO:0002292 GO:0002293 GO:0002294 GO:0002295 GO:0002312 GO:0002313 GO:0002314 GO:0002335 GO:0002360 GO:0002363 GO:0002366 GO:0002376 GO:0002384 GO:0002443 GO:0002444 GO:0002446 GO:0002521 GO:0002526 GO:0002548 GO:0002637 GO:0002639 GO:0002673 GO:0002675 GO:0002682 GO:0002684 GO:0002685 GO:0002687 GO:0002688 GO:0002690 GO:0002694 GO:0002696 GO:0002697 GO:0002699 GO:0002700 GO:0002702 GO:0002703 GO:0002705 GO:0002706 GO:0002708 GO:0002709 GO:0002711 GO:0002718 GO:0002720 GO:0002724 GO:0002726 GO:0002790 GO:0002791 GO:0002819 GO:0002821 GO:0002822 GO:0002824 GO:0002828 GO:0002830 GO:0003674 GO:0005102 GO:0005125 GO:0005126 GO:0005138 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0005788 GO:0005896 GO:0006355 GO:0006357 GO:0006417 GO:0006810 GO:0006915 GO:0006925 GO:0006935 GO:0006950 GO:0006952 GO:0006953 GO:0006954 GO:0006955 GO:0006959 GO:0006979 GO:0007165 GO:0007166 GO:0007259 GO:0008083 GO:0008150 GO:0008152 GO:0008219 GO:0008283 GO:0008284 GO:0008285 GO:0009058 GO:0009059 GO:0009605 GO:0009607 GO:0009611 GO:0009615 GO:0009617 GO:0009719 GO:0009725 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009894 GO:0009896 GO:0009914 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010033 GO:0010035 GO:0010243 GO:0010467 GO:0010468 GO:0010543 GO:0010556 GO:0010557 GO:0010558 GO:0010562 GO:0010573 GO:0010574 GO:0010575 GO:0010604 GO:0010605 GO:0010608 GO:0010628 GO:0010629 GO:0010646 GO:0010647 GO:0010648 GO:0010712 GO:0010713 GO:0010715 GO:0010717 GO:0010718 GO:0010720 GO:0010721 GO:0010817 GO:0010883 GO:0010888 GO:0012501 GO:0014013 GO:0014015 GO:0014070 GO:0014823 GO:0015833 GO:0016043 GO:0016477 GO:0019219 GO:0019220 GO:0019221 GO:0019222 GO:0019725 GO:0022407 GO:0022409 GO:0022603 GO:0023051 GO:0023056 GO:0023057 GO:0023061 GO:0030030 GO:0030072 GO:0030098 GO:0030154 GO:0030155 GO:0030168 GO:0030183 GO:0030217 GO:0030334 GO:0030335 GO:0030545 GO:0030546 GO:0030595 GO:0031018 GO:0031099 GO:0031100 GO:0031175 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031329 GO:0031331 GO:0031347 GO:0031349 GO:0031399 GO:0031401 GO:0031960 GO:0031974 GO:0032101 GO:0032103 GO:0032494 GO:0032496 GO:0032501 GO:0032502 GO:0032642 GO:0032651 GO:0032652 GO:0032653 GO:0032660 GO:0032665 GO:0032675 GO:0032677 GO:0032680 GO:0032682 GO:0032722 GO:0032731 GO:0032732 GO:0032733 GO:0032740 GO:0032745 GO:0032755 GO:0032757 GO:0032760 GO:0032879 GO:0032880 GO:0032940 GO:0032944 GO:0032946 GO:0032965 GO:0032966 GO:0032991 GO:0033028 GO:0033135 GO:0033138 GO:0033500 GO:0033554 GO:0033993 GO:0034103 GO:0034104 GO:0034110 GO:0034112 GO:0034248 GO:0034250 GO:0034599 GO:0034614 GO:0035633 GO:0035710 GO:0040011 GO:0040012 GO:0040017 GO:0042093 GO:0042102 GO:0042110 GO:0042113 GO:0042127 GO:0042129 GO:0042221 GO:0042325 GO:0042327 GO:0042330 GO:0042542 GO:0042592 GO:0042593 GO:0042742 GO:0042802 GO:0042886 GO:0042981 GO:0043030 GO:0043065 GO:0043066 GO:0043067 GO:0043068 GO:0043069 GO:0043170 GO:0043207 GO:0043233 GO:0043235 GO:0043367 GO:0043369 GO:0043373 GO:0043408 GO:0043410 GO:0044093 GO:0044237 GO:0044249 GO:0044419 GO:0045124 GO:0045165 GO:0045321 GO:0045595 GO:0045596 GO:0045597 GO:0045598 GO:0045599 GO:0045667 GO:0045669 GO:0045685 GO:0045727 GO:0045765 GO:0045779 GO:0045785 GO:0045893 GO:0045934 GO:0045935 GO:0045937 GO:0045944 GO:0046425 GO:0046427 GO:0046631 GO:0046632 GO:0046649 GO:0046850 GO:0046851 GO:0046879 GO:0046883 GO:0046903 GO:0048018 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048545 GO:0048583 GO:0048584 GO:0048585 GO:0048660 GO:0048661 GO:0048710 GO:0048732 GO:0048856 GO:0048869 GO:0048870 GO:0048871 GO:0048878 GO:0050670 GO:0050671 GO:0050673 GO:0050708 GO:0050727 GO:0050729 GO:0050730 GO:0050731 GO:0050767 GO:0050768 GO:0050769 GO:0050776 GO:0050778 GO:0050789 GO:0050793 GO:0050794 GO:0050796 GO:0050829 GO:0050830 GO:0050863 GO:0050864 GO:0050865 GO:0050867 GO:0050870 GO:0050871 GO:0050896 GO:0050900 GO:0050920 GO:0050921 GO:0051046 GO:0051049 GO:0051052 GO:0051054 GO:0051090 GO:0051091 GO:0051093 GO:0051094 GO:0051128 GO:0051130 GO:0051171 GO:0051172 GO:0051173 GO:0051174 GO:0051179 GO:0051223 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051246 GO:0051247 GO:0051249 GO:0051251 GO:0051252 GO:0051253 GO:0051254 GO:0051384 GO:0051607 GO:0051707 GO:0051716 GO:0051960 GO:0051961 GO:0051962 GO:0060147 GO:0060149 GO:0060249 GO:0060251 GO:0060252 GO:0060255 GO:0060284 GO:0060326 GO:0060341 GO:0060759 GO:0060761 GO:0060964 GO:0060965 GO:0060966 GO:0060967 GO:0061470 GO:0061888 GO:0062197 GO:0065007 GO:0065008 GO:0065009 GO:0070013 GO:0070050 GO:0070091 GO:0070092 GO:0070102 GO:0070201 GO:0070301 GO:0070663 GO:0070665 GO:0070851 GO:0070887 GO:0070920 GO:0071216 GO:0071219 GO:0071222 GO:0071310 GO:0071396 GO:0071674 GO:0071702 GO:0071704 GO:0071705 GO:0071840 GO:0071887 GO:0072540 GO:0072574 GO:0072575 GO:0080090 GO:0080134 GO:0090087 GO:0090091 GO:0090276 GO:0090330 GO:0090594 GO:0097421 GO:0097529 GO:0097696 GO:0098542 GO:0098586 GO:0098772 GO:0098796 GO:0098797 GO:0098802 GO:0110165 GO:0120036 GO:0140352 GO:0140546 GO:0140677 GO:0140747 GO:0150077 GO:0150078 GO:1900015 GO:1900017 GO:1900368 GO:1900369 GO:1901342 GO:1901576 GO:1901698 GO:1901700 GO:1901701 GO:1901731 GO:1902510 GO:1902512 GO:1902531 GO:1902533 GO:1902680 GO:1902893 GO:1902895 GO:1903037 GO:1903039 GO:1903053 GO:1903055 GO:1903131 GO:1903530 GO:1903555 GO:1903557 GO:1903624 GO:1903626 GO:1903798 GO:1903799 GO:1903978 GO:1904035 GO:1904037 GO:1904892 GO:1904894 GO:1904994 GO:1904996 GO:1905952 GO:1905953 GO:2000026 GO:2000145 GO:2000147 GO:2000551 GO:2000553 GO:2000628 GO:2000630 GO:2000634 GO:2000635 GO:2000659 GO:2000660 GO:2000674 GO:2000676 GO:2001141
3570	interleukin 6 receptor	IL6R	Homo sapiens (human)	9606	Alzheimer's disease Huntington's disease hyper IgE syndrome obesity stomach cancer	DOID:0080545 DOID:10534 DOID:10652 DOID:12858 DOID:9970	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment CD4-positive, alpha-beta T cell lineage commitment T cell lineage commitment T-helper 17 cell lineage commitment T-helper cell lineage commitment acute inflammatory response acute-phase response alpha-beta T cell lineage commitment anatomical structure development apical plasma membrane apoptotic signaling pathway binding biological process involved in interspecies interaction between organisms biological regulation biological_process biosynthetic process cell chemotaxis cell fate commitment cell migration cell motility cell surface receptor signaling pathway cellular anatomical entity cellular biosynthetic process cellular developmental process cellular metabolic process cellular process cellular_component chemotaxis ciliary neurotrophic factor binding ciliary neurotrophic factor receptor activity ciliary neurotrophic factor receptor complex ciliary neurotrophic factor-mediated signaling pathway cytokine binding cytokine production cytokine receptor activity cytokine receptor binding cytokine-mediated signaling pathway defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to bacterium defense response to other organism defense response developmental process endocrine pancreas development enzyme binding external side of plasma membrane extracellular region extracellular space extrinsic apoptotic signaling pathway gene expression growth factor binding growth factor receptor binding hepatic immune response identical protein binding immune effector process immune receptor activity immune response immune system process inflammatory response interleukin-11 binding interleukin-11 receptor activity interleukin-11-mediated signaling pathway interleukin-6 binding interleukin-6 receptor activity interleukin-6 receptor binding interleukin-6 receptor complex interleukin-6-mediated signaling pathway leukocyte chemotaxis leukocyte mediated immunity leukocyte migration locomotion macromolecule biosynthetic process macromolecule metabolic process membrane protein complex membrane metabolic process molecular transducer activity molecular_function monocyte chemotaxis mononuclear cell migration multicellular organismal process myeloid leukocyte mediated immunity myeloid leukocyte migration negative regulation of biological process negative regulation of biosynthetic process negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of collagen biosynthetic process negative regulation of collagen metabolic process negative regulation of cytokine production negative regulation of gene expression negative regulation of interleukin-8 production negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process neutrophil mediated immunity organ or tissue specific immune response organic substance biosynthetic process organic substance metabolic process plasma membrane protein complex plasma membrane region plasma membrane signaling receptor complex plasma membrane positive regulation of MAPK cascade positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell adhesion positive regulation of cell communication positive regulation of cell differentiation positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cell proliferation involved in kidney development positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of chemokine production positive regulation of chemotaxis positive regulation of cytokine production positive regulation of developmental process positive regulation of gene expression positive regulation of glomerular mesangial cell proliferation positive regulation of homotypic cell-cell adhesion positive regulation of immune system process positive regulation of interleukin-6 production positive regulation of intracellular signal transduction positive regulation of leukocyte chemotaxis positive regulation of leukocyte migration positive regulation of locomotion positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of osteoblast differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of platelet aggregation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of smooth muscle cell proliferation protein binding protein dimerization activity protein homodimerization activity protein-containing complex receptor complex receptor signaling pathway via STAT regulation of MAPK cascade regulation of biological process regulation of biosynthetic process regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell differentiation regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cell proliferation involved in kidney development regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of chemokine production regulation of chemotaxis regulation of collagen biosynthetic process regulation of collagen metabolic process regulation of cytokine production regulation of developmental process regulation of gene expression regulation of glomerular mesangial cell proliferation regulation of homotypic cell-cell adhesion regulation of immune system process regulation of interleukin-6 production regulation of interleukin-8 production regulation of intracellular signal transduction regulation of leukocyte chemotaxis regulation of leukocyte migration regulation of locomotion regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of osteoblast differentiation regulation of peptidyl-tyrosine phosphorylation regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of platelet activation regulation of platelet aggregation regulation of primary metabolic process regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of response to external stimulus regulation of response to stimulus regulation of signal transduction regulation of signaling regulation of smooth muscle cell proliferation response to bacterium response to biotic stimulus response to chemical response to cytokine response to external biotic stimulus response to external stimulus response to organic substance response to other organism response to stimulus response to stress side of membrane signal transduction signaling receptor activity signaling receptor binding taxis transmembrane signaling receptor activity vascular endothelial growth factor production	GO:0001816 GO:0001817 GO:0001818 GO:0001819 GO:0001932 GO:0001934 GO:0002251 GO:0002252 GO:0002295 GO:0002360 GO:0002363 GO:0002376 GO:0002384 GO:0002443 GO:0002444 GO:0002446 GO:0002526 GO:0002548 GO:0002682 GO:0002684 GO:0002685 GO:0002687 GO:0002688 GO:0002690 GO:0003674 GO:0004888 GO:0004896 GO:0004897 GO:0004915 GO:0004921 GO:0005102 GO:0005126 GO:0005138 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0005886 GO:0005896 GO:0006935 GO:0006950 GO:0006952 GO:0006953 GO:0006954 GO:0006955 GO:0007165 GO:0007166 GO:0008150 GO:0008152 GO:0008284 GO:0009058 GO:0009059 GO:0009605 GO:0009607 GO:0009617 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009897 GO:0009966 GO:0009967 GO:0009987 GO:0010033 GO:0010467 GO:0010468 GO:0010543 GO:0010556 GO:0010557 GO:0010558 GO:0010562 GO:0010573 GO:0010604 GO:0010605 GO:0010628 GO:0010629 GO:0010646 GO:0010647 GO:0010712 GO:0010713 GO:0016020 GO:0016324 GO:0016477 GO:0019220 GO:0019221 GO:0019222 GO:0019838 GO:0019899 GO:0019955 GO:0019970 GO:0019981 GO:0022407 GO:0022409 GO:0023051 GO:0023056 GO:0030155 GO:0030334 GO:0030335 GO:0030595 GO:0031018 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031399 GO:0031401 GO:0032101 GO:0032103 GO:0032501 GO:0032502 GO:0032642 GO:0032675 GO:0032677 GO:0032717 GO:0032722 GO:0032755 GO:0032965 GO:0032966 GO:0032991 GO:0034097 GO:0034110 GO:0034112 GO:0038023 GO:0038154 GO:0040011 GO:0040012 GO:0040017 GO:0042127 GO:0042221 GO:0042325 GO:0042327 GO:0042330 GO:0042742 GO:0042802 GO:0042803 GO:0043170 GO:0043207 GO:0043235 GO:0043369 GO:0043373 GO:0043408 GO:0043410 GO:0044237 GO:0044249 GO:0044419 GO:0045165 GO:0045595 GO:0045597 GO:0045667 GO:0045669 GO:0045785 GO:0045937 GO:0046983 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048660 GO:0048661 GO:0048856 GO:0048869 GO:0048870 GO:0050730 GO:0050731 GO:0050789 GO:0050793 GO:0050794 GO:0050829 GO:0050830 GO:0050865 GO:0050896 GO:0050900 GO:0050920 GO:0050921 GO:0051094 GO:0051171 GO:0051173 GO:0051174 GO:0051239 GO:0051240 GO:0051241 GO:0051246 GO:0051247 GO:0051707 GO:0060089 GO:0060255 GO:0060326 GO:0065007 GO:0070102 GO:0070110 GO:0070119 GO:0070120 GO:0070851 GO:0071674 GO:0071704 GO:0072124 GO:0072126 GO:0072540 GO:0080090 GO:0090330 GO:0097190 GO:0097191 GO:0097529 GO:0097696 GO:0098542 GO:0098552 GO:0098590 GO:0098796 GO:0098797 GO:0098802 GO:0110165 GO:0140375 GO:1901576 GO:1901722 GO:1901724 GO:1901731 GO:1902531 GO:1902533 GO:2000145 GO:2000147
3572	interleukin 6 cytokine family signal transducer	IL6ST	Homo sapiens (human)	9606	arteriosclerosis hyper IgE recurrent infection syndrome 4 hyperandrogenism primary immunodeficiency disease	DOID:0080596 DOID:11613 DOID:2349 DOID:612	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment CD4-positive, alpha-beta T cell lineage commitment T cell lineage commitment T-helper 17 cell lineage commitment T-helper cell lineage commitment alpha-beta T cell lineage commitment anatomical structure development binding biological regulation biological_process carbohydrate metabolic process cell body cell development cell fate commitment cell projection cell surface receptor signaling pathway cellular anatomical entity cellular developmental process cellular metabolic process cellular process cellular_component ciliary neurotrophic factor receptor activity ciliary neurotrophic factor receptor binding ciliary neurotrophic factor receptor complex ciliary neurotrophic factor-mediated signaling pathway columnar/cuboidal epithelial cell development coreceptor activity cytokine binding cytokine receptor activity cytokine receptor binding cytokine-mediated signaling pathway dendrite developmental process energy derivation by oxidation of organic compounds energy reserve metabolic process enzyme activator activity enzyme regulator activity enzyme-linked receptor protein signaling pathway epithelial cell development external side of plasma membrane extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular region extracellular space extracellular vesicle generation of precursor metabolites and energy glucan metabolic process glycogen metabolic process growth factor binding growth factor receptor binding identical protein binding immune receptor activity interleukin-11 binding interleukin-11 receptor activity interleukin-11-mediated signaling pathway interleukin-17 receptor activity interleukin-27 receptor activity interleukin-27-mediated signaling pathway interleukin-6 binding interleukin-6 receptor activity interleukin-6 receptor binding interleukin-6 receptor complex interleukin-6-mediated signaling pathway intestinal epithelial cell development kinase activator activity kinase regulator activity leukemia inhibitory factor receptor activity leukemia inhibitory factor signaling pathway macromolecule metabolic process membrane microdomain membrane protein complex membrane raft membrane-bounded organelle membrane metabolic process molecular function activator activity molecular function regulator activity molecular transducer activity molecular_function negative regulation of apoptotic process negative regulation of biological process negative regulation of cell communication negative regulation of cellular process negative regulation of cytokine-mediated signaling pathway negative regulation of interleukin-6-mediated signaling pathway negative regulation of neuron apoptotic process negative regulation of programmed cell death negative regulation of response to cytokine stimulus negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling neuron projection neuronal cell body oncostatin-M receptor activity oncostatin-M receptor complex oncostatin-M-mediated signaling pathway organelle organic substance metabolic process plasma membrane bounded cell projection plasma membrane protein complex plasma membrane signaling receptor complex plasma membrane polysaccharide metabolic process positive regulation of Notch signaling pathway positive regulation of T cell activation positive regulation of T cell proliferation positive regulation of acute inflammatory response positive regulation of adaptive immune response positive regulation of astrocyte differentiation positive regulation of biological process positive regulation of biosynthetic process positive regulation of cardiac muscle hypertrophy positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell communication positive regulation of cell development positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of defense response positive regulation of developmental process positive regulation of gene expression positive regulation of glial cell differentiation positive regulation of gliogenesis positive regulation of homotypic cell-cell adhesion positive regulation of immune response positive regulation of immune system process positive regulation of inflammatory response positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of lymphocyte activation positive regulation of lymphocyte proliferation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of mononuclear cell proliferation positive regulation of multicellular organismal process positive regulation of muscle hypertrophy positive regulation of nervous system development positive regulation of neurogenesis positive regulation of osteoblast differentiation positive regulation of platelet aggregation positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of vascular endothelial growth factor production primary metabolic process protein binding protein kinase activator activity protein kinase regulator activity protein tyrosine kinase activator activity protein-containing complex receptor complex receptor signaling pathway via STAT regulation of Notch signaling pathway regulation of T cell activation regulation of T cell proliferation regulation of acute inflammatory response regulation of adaptive immune response regulation of apoptotic process regulation of astrocyte differentiation regulation of biological process regulation of biosynthetic process regulation of cardiac muscle hypertrophy regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell development regulation of cell differentiation regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cytokine production regulation of cytokine-mediated signaling pathway regulation of defense response regulation of developmental process regulation of gene expression regulation of glial cell differentiation regulation of gliogenesis regulation of homotypic cell-cell adhesion regulation of immune response regulation of immune system process regulation of inflammatory response regulation of interleukin-6-mediated signaling pathway regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of leukocyte proliferation regulation of lymphocyte activation regulation of lymphocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of mononuclear cell proliferation regulation of multicellular organismal development regulation of multicellular organismal process regulation of muscle adaptation regulation of muscle hypertrophy regulation of muscle system process regulation of nervous system development regulation of neurogenesis regulation of neuron apoptotic process regulation of osteoblast differentiation regulation of platelet activation regulation of platelet aggregation regulation of programmed cell death regulation of response to cytokine stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of signal transduction regulation of signaling regulation of system process regulation of vascular endothelial growth factor production response to chemical response to cytokine response to organic substance response to stimulus scaffold protein binding side of membrane signal transduction signaling receptor activity signaling receptor binding transmembrane signaling receptor activity vesicle	GO:0001817 GO:0001819 GO:0001959 GO:0001960 GO:0002064 GO:0002066 GO:0002295 GO:0002360 GO:0002363 GO:0002673 GO:0002675 GO:0002682 GO:0002684 GO:0002694 GO:0002696 GO:0002819 GO:0002821 GO:0003674 GO:0004888 GO:0004896 GO:0004897 GO:0004915 GO:0004921 GO:0004923 GO:0004924 GO:0005102 GO:0005126 GO:0005127 GO:0005138 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0005886 GO:0005896 GO:0005900 GO:0005975 GO:0005976 GO:0005977 GO:0006091 GO:0006112 GO:0007165 GO:0007166 GO:0007167 GO:0008047 GO:0008150 GO:0008152 GO:0008284 GO:0008593 GO:0009889 GO:0009891 GO:0009893 GO:0009897 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010033 GO:0010468 GO:0010543 GO:0010556 GO:0010557 GO:0010574 GO:0010575 GO:0010604 GO:0010611 GO:0010613 GO:0010628 GO:0010646 GO:0010647 GO:0010648 GO:0010720 GO:0014013 GO:0014015 GO:0014742 GO:0014743 GO:0015026 GO:0015980 GO:0016020 GO:0019207 GO:0019209 GO:0019221 GO:0019222 GO:0019838 GO:0019887 GO:0019955 GO:0019970 GO:0019981 GO:0022407 GO:0022409 GO:0023051 GO:0023056 GO:0023057 GO:0030155 GO:0030234 GO:0030295 GO:0030296 GO:0030368 GO:0030425 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031347 GO:0031349 GO:0031982 GO:0032101 GO:0032103 GO:0032502 GO:0032944 GO:0032946 GO:0032991 GO:0034097 GO:0034110 GO:0034112 GO:0038023 GO:0038154 GO:0038165 GO:0042102 GO:0042127 GO:0042129 GO:0042221 GO:0042802 GO:0042981 GO:0042995 GO:0043005 GO:0043025 GO:0043066 GO:0043067 GO:0043069 GO:0043170 GO:0043226 GO:0043227 GO:0043230 GO:0043235 GO:0043369 GO:0043373 GO:0043502 GO:0043523 GO:0043524 GO:0044042 GO:0044057 GO:0044237 GO:0044238 GO:0044297 GO:0045121 GO:0045165 GO:0045509 GO:0045595 GO:0045597 GO:0045667 GO:0045669 GO:0045685 GO:0045687 GO:0045747 GO:0045785 GO:0048468 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048710 GO:0048711 GO:0048856 GO:0048861 GO:0048869 GO:0050670 GO:0050671 GO:0050727 GO:0050729 GO:0050767 GO:0050769 GO:0050776 GO:0050778 GO:0050789 GO:0050793 GO:0050794 GO:0050863 GO:0050865 GO:0050867 GO:0050870 GO:0050896 GO:0051094 GO:0051239 GO:0051240 GO:0051249 GO:0051251 GO:0051960 GO:0051962 GO:0060089 GO:0060255 GO:0060284 GO:0060576 GO:0060759 GO:0060761 GO:0065007 GO:0065010 GO:0070062 GO:0070102 GO:0070103 GO:0070104 GO:0070106 GO:0070110 GO:0070120 GO:0070663 GO:0070665 GO:0070851 GO:0071704 GO:0072540 GO:0080134 GO:0090257 GO:0090330 GO:0097110 GO:0097696 GO:0098552 GO:0098772 GO:0098796 GO:0098797 GO:0098802 GO:0098857 GO:0110165 GO:0120025 GO:0140375 GO:0140677 GO:1901731 GO:1903037 GO:1903039 GO:1903561 GO:2000026
3574	interleukin 7	IL7	Homo sapiens (human)	9606	epidermodysplasia verruciformis	DOID:13777	B cell activation B cell proliferation T cell lineage commitment anatomical structure homeostasis anatomical structure morphogenesis animal organ morphogenesis apoptotic signaling pathway binding biological regulation biological_process bone resorption cell activation cell communication cell fate commitment cell population proliferation cell surface receptor signaling pathway cell-cell signaling cellular anatomical entity cellular developmental process cellular process cellular_component collagen-containing extracellular matrix cytokine activity cytokine receptor binding cytokine-mediated signaling pathway developmental growth developmental process external encapsulating structure extracellular matrix extracellular region extracellular space extrinsic apoptotic signaling pathway growth factor activity growth factor receptor binding growth homeostasis of number of cells within a tissue homeostasis of number of cells homeostatic process humoral immune response immune response immune system process interleukin-7 receptor binding interleukin-7-mediated signaling pathway leukocyte activation leukocyte proliferation lymphocyte activation lymphocyte proliferation molecular function activator activity molecular function regulator activity molecular_function mononuclear cell proliferation multicellular organismal process multicellular organismal-level homeostasis negative regulation of apoptotic process negative regulation of apoptotic signaling pathway negative regulation of biological process negative regulation of cell communication negative regulation of cellular process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of programmed cell death negative regulation of response to stimulus negative regulation of signal transduction in absence of ligand negative regulation of signal transduction negative regulation of signaling organ growth positive regulation of B cell activation positive regulation of B cell differentiation positive regulation of B cell proliferation positive regulation of T cell activation positive regulation of T cell differentiation positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell communication positive regulation of cell development positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of chemokine production positive regulation of cytokine production positive regulation of cytokine-mediated signaling pathway positive regulation of developmental growth positive regulation of developmental process positive regulation of gene expression positive regulation of growth positive regulation of hemopoiesis positive regulation of immune system process positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte differentiation positive regulation of leukocyte proliferation positive regulation of lymphocyte activation positive regulation of lymphocyte differentiation positive regulation of lymphocyte proliferation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of mononuclear cell proliferation positive regulation of multicellular organismal process positive regulation of organ growth positive regulation of response to cytokine stimulus positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling protein binding receptor ligand activity regulation of B cell activation regulation of B cell differentiation regulation of B cell proliferation regulation of T cell activation regulation of T cell differentiation regulation of apoptotic process regulation of apoptotic signaling pathway regulation of biological process regulation of biosynthetic process regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell development regulation of cell differentiation regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of chemokine production regulation of cytokine production regulation of cytokine-mediated signaling pathway regulation of developmental growth regulation of developmental process regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of extrinsic apoptotic signaling pathway regulation of gene expression regulation of growth regulation of hemopoiesis regulation of immune system process regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of leukocyte proliferation regulation of lymphocyte activation regulation of lymphocyte differentiation regulation of lymphocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of mononuclear cell proliferation regulation of multicellular organismal development regulation of multicellular organismal process regulation of organ growth regulation of programmed cell death regulation of response to cytokine stimulus regulation of response to stimulus regulation of signal transduction regulation of signaling response to stimulus signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity signaling tissue homeostasis	GO:0001775 GO:0001817 GO:0001819 GO:0001894 GO:0001959 GO:0001961 GO:0002360 GO:0002376 GO:0002682 GO:0002684 GO:0002694 GO:0002696 GO:0003674 GO:0005102 GO:0005125 GO:0005126 GO:0005139 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0006955 GO:0006959 GO:0007154 GO:0007165 GO:0007166 GO:0007267 GO:0008083 GO:0008150 GO:0008283 GO:0008284 GO:0009653 GO:0009887 GO:0009889 GO:0009891 GO:0009893 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0010646 GO:0010647 GO:0010648 GO:0010720 GO:0019221 GO:0019222 GO:0022407 GO:0022409 GO:0023051 GO:0023052 GO:0023056 GO:0023057 GO:0030155 GO:0030312 GO:0030545 GO:0030546 GO:0030888 GO:0030890 GO:0031012 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0032501 GO:0032502 GO:0032642 GO:0032722 GO:0032943 GO:0032944 GO:0032946 GO:0035265 GO:0038111 GO:0040007 GO:0040008 GO:0042100 GO:0042113 GO:0042127 GO:0042592 GO:0042981 GO:0043066 GO:0043067 GO:0043069 GO:0045165 GO:0045321 GO:0045453 GO:0045577 GO:0045579 GO:0045580 GO:0045582 GO:0045595 GO:0045597 GO:0045619 GO:0045621 GO:0045785 GO:0045927 GO:0046620 GO:0046622 GO:0046649 GO:0046651 GO:0048018 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048589 GO:0048638 GO:0048639 GO:0048869 GO:0048871 GO:0048872 GO:0048873 GO:0050670 GO:0050671 GO:0050789 GO:0050793 GO:0050794 GO:0050863 GO:0050864 GO:0050865 GO:0050867 GO:0050870 GO:0050871 GO:0050896 GO:0051094 GO:0051239 GO:0051240 GO:0051249 GO:0051251 GO:0060249 GO:0060255 GO:0060284 GO:0060759 GO:0060760 GO:0062023 GO:0065007 GO:0070661 GO:0070663 GO:0070665 GO:0070851 GO:0097190 GO:0097191 GO:0098772 GO:0110165 GO:0140677 GO:1901099 GO:1902105 GO:1902107 GO:1903037 GO:1903039 GO:1903706 GO:1903708 GO:2000026 GO:2001233 GO:2001234 GO:2001236 GO:2001237 GO:2001239 GO:2001240
3575	interleukin 7 receptor	IL7R	Homo sapiens (human)	9606	colon cancer lung non-small cell carcinoma primary immunodeficiency disease severe combined immunodeficiency stomach cancer	DOID:10534 DOID:219 DOID:3908 DOID:612 DOID:627	B cell activation B cell homeostasis B cell proliferation T cell activation T cell differentiation in thymus T cell differentiation T cell homeostasis T cell mediated cytotoxicity T cell mediated immunity adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains adaptive immune response anatomical structure development anatomical structure morphogenesis animal organ development antigen binding binding biological process involved in interspecies interaction between organisms biological regulation biological_process biosynthetic process bounding membrane of organelle cell activation cell development cell differentiation cell killing cell morphogenesis cell population proliferation cell surface receptor signaling pathway cellular anatomical entity cellular biosynthetic process cellular component organization or biogenesis cellular component organization cellular developmental process cellular homeostasis cellular metabolic process cellular process cellular_component clathrin-coated endocytic vesicle membrane clathrin-coated vesicle membrane coated vesicle membrane cytokine receptor activity cytokine-mediated signaling pathway cytoplasmic vesicle membrane cytosol defense response to Gram-positive bacterium defense response to bacterium defense response to other organism defense response developmental process endocytic vesicle membrane external side of plasma membrane extracellular region gene expression hematopoietic or lymphoid organ development hemopoiesis homeostasis of number of cells homeostatic process immune effector process immune receptor activity immune response immune system process interleukin-7 receptor activity interleukin-7-mediated signaling pathway leukocyte activation leukocyte differentiation leukocyte homeostasis leukocyte mediated cytotoxicity leukocyte mediated immunity leukocyte proliferation lymph node development lymphocyte activation lymphocyte differentiation lymphocyte homeostasis lymphocyte mediated immunity lymphocyte proliferation macromolecule biosynthetic process macromolecule metabolic process membrane metabolic process molecular transducer activity molecular_function mononuclear cell differentiation mononuclear cell proliferation multicellular organismal process multicellular organismal-level homeostasis negative regulation of T cell apoptotic process negative regulation of T cell mediated cytotoxicity negative regulation of T cell mediated immunity negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of adaptive immune response negative regulation of apoptotic process negative regulation of biological process negative regulation of cell killing negative regulation of cellular process negative regulation of immune effector process negative regulation of immune response negative regulation of immune system process negative regulation of leukocyte apoptotic process negative regulation of leukocyte mediated cytotoxicity negative regulation of leukocyte mediated immunity negative regulation of lymphocyte apoptotic process negative regulation of lymphocyte mediated immunity negative regulation of programmed cell death negative regulation of response to stimulus nucleoplasm organelle membrane organic substance biosynthetic process organic substance metabolic process plasma membrane positive regulation of T cell activation positive regulation of T cell differentiation in thymus positive regulation of T cell differentiation positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell communication positive regulation of cell development positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of developmental process positive regulation of gene expression positive regulation of hemopoiesis positive regulation of immune system process positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte differentiation positive regulation of lymphocyte activation positive regulation of lymphocyte differentiation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via STAT positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling protein binding regulation of DNA metabolic process regulation of DNA recombination regulation of T cell activation regulation of T cell apoptotic process regulation of T cell differentiation in thymus regulation of T cell differentiation regulation of T cell mediated cytotoxicity regulation of T cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of anatomical structure size regulation of apoptotic process regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell development regulation of cell differentiation regulation of cell killing regulation of cell population proliferation regulation of cell size regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular component size regulation of cellular metabolic process regulation of cellular process regulation of developmental process regulation of gene expression regulation of hemopoiesis regulation of immune effector process regulation of immune response regulation of immune system process regulation of leukocyte activation regulation of leukocyte apoptotic process regulation of leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of leukocyte mediated cytotoxicity regulation of leukocyte mediated immunity regulation of lymphocyte activation regulation of lymphocyte apoptotic process regulation of lymphocyte differentiation regulation of lymphocyte mediated immunity regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal development regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of primary metabolic process regulation of programmed cell death regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT regulation of response to stimulus regulation of signal transduction regulation of signaling response to bacterium response to biotic stimulus response to external biotic stimulus response to external stimulus response to other organism response to stimulus response to stress side of membrane signal transduction signaling receptor activity transmembrane signaling receptor activity vesicle membrane	GO:0000018 GO:0000902 GO:0001775 GO:0001776 GO:0001782 GO:0001906 GO:0001909 GO:0001910 GO:0001911 GO:0001913 GO:0001914 GO:0001915 GO:0002250 GO:0002252 GO:0002260 GO:0002376 GO:0002443 GO:0002449 GO:0002456 GO:0002460 GO:0002521 GO:0002682 GO:0002683 GO:0002684 GO:0002694 GO:0002696 GO:0002697 GO:0002698 GO:0002703 GO:0002704 GO:0002706 GO:0002707 GO:0002709 GO:0002710 GO:0002819 GO:0002820 GO:0002822 GO:0002823 GO:0003674 GO:0003823 GO:0004888 GO:0004896 GO:0004917 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005654 GO:0005829 GO:0005886 GO:0006950 GO:0006952 GO:0006955 GO:0007165 GO:0007166 GO:0008150 GO:0008152 GO:0008283 GO:0008284 GO:0008361 GO:0009058 GO:0009059 GO:0009605 GO:0009607 GO:0009617 GO:0009653 GO:0009889 GO:0009891 GO:0009893 GO:0009897 GO:0009966 GO:0009967 GO:0009987 GO:0010467 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0010646 GO:0010647 GO:0010720 GO:0012506 GO:0016020 GO:0016043 GO:0019219 GO:0019221 GO:0019222 GO:0019725 GO:0022407 GO:0022409 GO:0023051 GO:0023056 GO:0030097 GO:0030098 GO:0030154 GO:0030155 GO:0030217 GO:0030659 GO:0030662 GO:0030665 GO:0030666 GO:0030669 GO:0031090 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031341 GO:0031342 GO:0032501 GO:0032502 GO:0032535 GO:0032943 GO:0033077 GO:0033081 GO:0033089 GO:0038023 GO:0038111 GO:0042100 GO:0042110 GO:0042113 GO:0042127 GO:0042592 GO:0042742 GO:0042981 GO:0043029 GO:0043066 GO:0043067 GO:0043069 GO:0043170 GO:0043207 GO:0044237 GO:0044249 GO:0044419 GO:0045321 GO:0045580 GO:0045582 GO:0045595 GO:0045597 GO:0045619 GO:0045621 GO:0045785 GO:0046425 GO:0046427 GO:0046649 GO:0046651 GO:0048468 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048534 GO:0048535 GO:0048583 GO:0048584 GO:0048585 GO:0048856 GO:0048869 GO:0048871 GO:0048872 GO:0050776 GO:0050777 GO:0050789 GO:0050793 GO:0050794 GO:0050830 GO:0050863 GO:0050865 GO:0050867 GO:0050870 GO:0050896 GO:0051052 GO:0051094 GO:0051171 GO:0051239 GO:0051240 GO:0051249 GO:0051251 GO:0051707 GO:0060089 GO:0060255 GO:0060284 GO:0065007 GO:0065008 GO:0070228 GO:0070229 GO:0070232 GO:0070233 GO:0070661 GO:0071704 GO:0071840 GO:0080090 GO:0090066 GO:0098542 GO:0098552 GO:0098588 GO:0110165 GO:0140375 GO:1901576 GO:1902105 GO:1902107 GO:1903037 GO:1903039 GO:1903131 GO:1903706 GO:1903708 GO:1904892 GO:1904894 GO:2000026 GO:2000106 GO:2000107
3577	C-X-C motif chemokine receptor 1	CXCR1	Homo sapiens (human)	9606	human immunodeficiency virus infectious disease pyelonephritis urinary tract infection	DOID:0080784 DOID:11400 DOID:526	C-C chemokine binding C-C chemokine receptor activity C-X-C chemokine binding C-X-C chemokine receptor activity G protein-coupled chemoattractant receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway binding biological regulation biological_process bounding membrane of organelle calcium-mediated signaling cell chemotaxis cell migration cell motility cell surface receptor signaling pathway cellular anatomical entity cellular process cellular_component chemokine binding chemokine receptor activity chemokine-mediated signaling pathway chemotaxis cytokine binding cytokine receptor activity cytokine-mediated signaling pathway cytoplasmic vesicle membrane dendritic cell chemotaxis dendritic cell migration endocytosis establishment of localization external side of plasma membrane granulocyte chemotaxis granulocyte migration immune receptor activity immune response immune system process import into cell interleukin-8 binding interleukin-8 receptor activity interleukin-8-mediated signaling pathway intracellular signal transduction leukocyte chemotaxis leukocyte migration localization locomotion membrane molecular transducer activity molecular_function mononuclear cell migration myeloid leukocyte migration neutrophil chemotaxis neutrophil migration organelle membrane plasma membrane positive regulation of cytosolic calcium ion concentration protein binding receptor internalization receptor-mediated endocytosis regulation of biological process regulation of biological quality regulation of cellular process response to stimulus second-messenger-mediated signaling secretory granule membrane side of membrane signal transduction signaling receptor activity taxis transmembrane signaling receptor activity transport vesicle membrane vesicle-mediated transport	GO:0001637 GO:0002376 GO:0002407 GO:0003674 GO:0004888 GO:0004896 GO:0004918 GO:0004930 GO:0004950 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0006810 GO:0006897 GO:0006898 GO:0006935 GO:0006955 GO:0007165 GO:0007166 GO:0007186 GO:0007204 GO:0008150 GO:0009897 GO:0009987 GO:0012506 GO:0016020 GO:0016192 GO:0016477 GO:0016493 GO:0016494 GO:0019221 GO:0019722 GO:0019932 GO:0019955 GO:0019956 GO:0019957 GO:0019958 GO:0019959 GO:0030593 GO:0030595 GO:0030659 GO:0030667 GO:0031090 GO:0031623 GO:0035556 GO:0036336 GO:0038023 GO:0038112 GO:0040011 GO:0042330 GO:0048870 GO:0050789 GO:0050794 GO:0050896 GO:0050900 GO:0051179 GO:0051234 GO:0060089 GO:0060326 GO:0065007 GO:0065008 GO:0070098 GO:0071621 GO:0071674 GO:0097529 GO:0097530 GO:0098552 GO:0098588 GO:0098657 GO:0110165 GO:0140375 GO:1990266
3578	interleukin 9	IL9	Homo sapiens (human)	9606	asthma respiratory syncytial virus infectious disease	DOID:1273 DOID:2841	B cell activation B cell differentiation B cell mediated immunity B cell proliferation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains adaptive immune response binding biological regulation biological_process cell activation cell differentiation cell population proliferation cell surface receptor signaling pathway cellular anatomical entity cellular developmental process cellular process cellular_component cytokine activity cytokine receptor binding cytokine-mediated signaling pathway defense response developmental process extracellular region extracellular space growth factor activity growth factor receptor binding immune effector process immune response immune system process immunoglobulin mediated immune response inflammatory response interleukin-9 receptor binding interleukin-9-mediated signaling pathway leukocyte activation leukocyte differentiation leukocyte mediated immunity leukocyte proliferation lymphocyte activation lymphocyte differentiation lymphocyte mediated immunity lymphocyte proliferation molecular function activator activity molecular function regulator activity molecular_function mononuclear cell differentiation mononuclear cell proliferation multicellular organismal process positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell growth positive regulation of cell population proliferation positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of gene expression positive regulation of growth positive regulation of interleukin-5 production positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process protein binding receptor ligand activity regulation of biological process regulation of biosynthetic process regulation of cell communication regulation of cell growth regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cytokine production regulation of gene expression regulation of growth regulation of interleukin-5 production regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT regulation of response to stimulus regulation of signal transduction regulation of signaling response to stimulus response to stress signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity	GO:0001558 GO:0001775 GO:0001817 GO:0001819 GO:0002250 GO:0002252 GO:0002376 GO:0002443 GO:0002449 GO:0002460 GO:0002521 GO:0003674 GO:0005102 GO:0005125 GO:0005126 GO:0005140 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0007165 GO:0007166 GO:0008083 GO:0008150 GO:0008283 GO:0008284 GO:0009889 GO:0009891 GO:0009893 GO:0009966 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0010646 GO:0016064 GO:0019221 GO:0019222 GO:0019724 GO:0023051 GO:0030098 GO:0030154 GO:0030183 GO:0030307 GO:0030545 GO:0030546 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0032501 GO:0032502 GO:0032674 GO:0032754 GO:0032943 GO:0038113 GO:0040008 GO:0042100 GO:0042113 GO:0042127 GO:0045321 GO:0045927 GO:0046425 GO:0046649 GO:0046651 GO:0048018 GO:0048518 GO:0048522 GO:0048583 GO:0048869 GO:0050789 GO:0050794 GO:0050896 GO:0051128 GO:0051239 GO:0051240 GO:0060255 GO:0065007 GO:0070661 GO:0070851 GO:0098772 GO:0110165 GO:0140677 GO:1903131 GO:1904892
3579	C-X-C motif chemokine receptor 2	CXCR2	Homo sapiens (human)	9606	IgA glomerulonephritis WHIM syndrome 2 acute pyelonephritis end stage renal disease urinary bladder cancer	DOID:0060973 DOID:11054 DOID:2986 DOID:559 DOID:783	C-C chemokine binding C-C chemokine receptor activity C-X-C chemokine binding C-X-C chemokine receptor activity G protein-coupled chemoattractant receptor activity G protein-coupled receptor activity G protein-coupled receptor signaling pathway acute inflammatory response to antigenic stimulus acute inflammatory response anatomical structure development anatomical structure morphogenesis binding biological regulation biological_process bounding membrane of organelle calcium-mediated signaling cell activation cell chemotaxis cell migration cell motility cell surface receptor signaling pathway cell surface cellular anatomical entity cellular defense response cellular process cellular_component chemokine binding chemokine receptor activity chemokine-mediated signaling pathway chemotaxis circulatory system process cytokine binding cytokine receptor activity cytokine-mediated signaling pathway cytoplasmic vesicle membrane cytoskeleton defense response dendritic cell chemotaxis dendritic cell migration developmental process endocytosis epithelial tube morphogenesis establishment of localization external side of plasma membrane granulocyte activation granulocyte chemotaxis granulocyte migration immune receptor activity immune response immune system process import into cell inflammatory response to antigenic stimulus inflammatory response interleukin-8 binding interleukin-8 receptor activity interleukin-8-mediated signaling pathway intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle intracellular signal transduction leukocyte activation leukocyte chemotaxis leukocyte migration localization locomotion lysosome lytic vacuole mast cell granule membrane-bounded organelle membrane metanephric tubule morphogenesis microtubule cytoskeleton midbrain development mitotic spindle molecular transducer activity molecular_function mononuclear cell migration morphogenesis of an epithelium multicellular organismal process myeloid leukocyte activation myeloid leukocyte migration negative regulation of apoptotic process negative regulation of biological process negative regulation of cellular process negative regulation of leukocyte apoptotic process negative regulation of myeloid cell apoptotic process negative regulation of neutrophil apoptotic process negative regulation of programmed cell death neutrophil activation neutrophil chemotaxis neutrophil migration non-membrane-bounded organelle nucleoplasm organelle membrane organelle phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane positive regulation of angiogenesis positive regulation of apoptotic process positive regulation of biological process positive regulation of cardiac muscle cell apoptotic process positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cellular process positive regulation of chemotaxis positive regulation of cytosolic calcium ion concentration positive regulation of developmental process positive regulation of granulocyte chemotaxis positive regulation of immune system process positive regulation of leukocyte chemotaxis positive regulation of leukocyte migration positive regulation of locomotion positive regulation of multicellular organismal process positive regulation of muscle cell apoptotic process positive regulation of neutrophil chemotaxis positive regulation of neutrophil migration positive regulation of programmed cell death positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of striated muscle cell apoptotic process positive regulation of vascular permeability positive regulation of vasculature development protein binding receptor internalization receptor-mediated endocytosis regulation of anatomical structure morphogenesis regulation of angiogenesis regulation of apoptotic process regulation of biological process regulation of biological quality regulation of cardiac muscle cell apoptotic process regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cellular process regulation of chemotaxis regulation of developmental process regulation of granulocyte chemotaxis regulation of immune system process regulation of leukocyte apoptotic process regulation of leukocyte chemotaxis regulation of leukocyte migration regulation of locomotion regulation of multicellular organismal development regulation of multicellular organismal process regulation of muscle cell apoptotic process regulation of myeloid cell apoptotic process regulation of neutrophil apoptotic process regulation of neutrophil chemotaxis regulation of neutrophil migration regulation of programmed cell death regulation of response to external stimulus regulation of response to stimulus regulation of striated muscle cell apoptotic process regulation of vascular permeability regulation of vasculature development response to stimulus response to stress second-messenger-mediated signaling secretory granule membrane side of membrane signal transduction signaling receptor activity spindle system process taxis tissue morphogenesis transmembrane signaling receptor activity transport tube morphogenesis vacuole vascular process in circulatory system vesicle membrane vesicle-mediated transport	GO:0000323 GO:0001637 GO:0001775 GO:0002009 GO:0002274 GO:0002376 GO:0002407 GO:0002437 GO:0002438 GO:0002526 GO:0002682 GO:0002684 GO:0002685 GO:0002687 GO:0002688 GO:0002690 GO:0003008 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0004896 GO:0004918 GO:0004930 GO:0004950 GO:0005488 GO:0005515 GO:0005575 GO:0005654 GO:0005764 GO:0005773 GO:0005819 GO:0005856 GO:0005886 GO:0006810 GO:0006897 GO:0006898 GO:0006935 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0006968 GO:0007165 GO:0007166 GO:0007186 GO:0007200 GO:0007204 GO:0008150 GO:0008284 GO:0009653 GO:0009897 GO:0009986 GO:0009987 GO:0010660 GO:0010661 GO:0010662 GO:0010663 GO:0010665 GO:0010666 GO:0012506 GO:0015630 GO:0016020 GO:0016192 GO:0016477 GO:0016493 GO:0016494 GO:0019221 GO:0019722 GO:0019932 GO:0019955 GO:0019956 GO:0019957 GO:0019958 GO:0019959 GO:0022603 GO:0030334 GO:0030335 GO:0030593 GO:0030595 GO:0030659 GO:0030667 GO:0030901 GO:0031090 GO:0031623 GO:0032101 GO:0032103 GO:0032501 GO:0032502 GO:0033029 GO:0033030 GO:0033032 GO:0033033 GO:0035239 GO:0035556 GO:0036230 GO:0036336 GO:0038023 GO:0038112 GO:0040011 GO:0040012 GO:0040017 GO:0042119 GO:0042127 GO:0042330 GO:0042629 GO:0042981 GO:0043065 GO:0043066 GO:0043067 GO:0043068 GO:0043069 GO:0043114 GO:0043117 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0045321 GO:0045765 GO:0045766 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048729 GO:0048856 GO:0048870 GO:0050789 GO:0050793 GO:0050794 GO:0050896 GO:0050900 GO:0050920 GO:0050921 GO:0051094 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0060089 GO:0060326 GO:0060562 GO:0065007 GO:0065008 GO:0070098 GO:0071621 GO:0071622 GO:0071624 GO:0071674 GO:0072173 GO:0072686 GO:0090022 GO:0090023 GO:0097529 GO:0097530 GO:0098552 GO:0098588 GO:0098657 GO:0110165 GO:0140375 GO:1901342 GO:1902622 GO:1902624 GO:1904018 GO:1990266 GO:2000026 GO:2000106 GO:2000107 GO:2000145 GO:2000147
3581	interleukin 9 receptor	IL9R	Homo sapiens (human)	9606			B cell mediated immunity adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains adaptive immune response binding biological regulation biological_process cell surface receptor signaling pathway cellular anatomical entity cellular process cellular_component cytokine binding cytokine receptor activity cytokine-mediated signaling pathway external side of plasma membrane extracellular space growth factor binding immune effector process immune receptor activity immune response immune system process immunoglobulin mediated immune response interleukin-9 binding interleukin-9 receptor activity interleukin-9-mediated signaling pathway leukocyte mediated immunity lymphocyte mediated immunity membrane molecular transducer activity molecular_function plasma membrane protein binding regulation of biological process regulation of cell population proliferation regulation of cellular process response to stimulus side of membrane signal transduction signaling receptor activity transmembrane signaling receptor activity	GO:0002250 GO:0002252 GO:0002376 GO:0002443 GO:0002449 GO:0002460 GO:0003674 GO:0004888 GO:0004896 GO:0004919 GO:0005488 GO:0005515 GO:0005575 GO:0005615 GO:0005886 GO:0006955 GO:0007165 GO:0007166 GO:0008150 GO:0009897 GO:0009987 GO:0016020 GO:0016064 GO:0019221 GO:0019724 GO:0019838 GO:0019955 GO:0019983 GO:0038023 GO:0038113 GO:0042127 GO:0050789 GO:0050794 GO:0050896 GO:0060089 GO:0065007 GO:0098552 GO:0110165 GO:0140375
3586	interleukin 10	IL10	Homo sapiens (human)	9606	Alzheimer's disease Behcet's disease Crohn's disease Graves ophthalmopathy Graves' disease Sjogren's syndrome acute pancreatitis aggressive periodontitis aphthous stomatitis arteriosclerosis asthma autoimmune thrombocytopenic purpura central nervous system lymphoma choroid disease chronic myeloid leukemia colon cancer common cold coronary artery disease diabetic retinopathy factor VIII deficiency gallbladder carcinoma glucosephosphate dehydrogenase deficiency graft-versus-host disease granulomatosis with polyangiitis hepatitis B hepatitis C hepatocellular carcinoma high grade glioma human immunodeficiency virus infectious disease inflammatory bowel disease liver carcinoma liver cirrhosis lymphoplasmacytic lymphoma major depressive disorder metabolic dysfunction-associated steatohepatitis multiple myeloma myocardial infarction oral squamous cell carcinoma otitis media pancreatic cancer panuveitis psoriasis retinal artery occlusion rheumatoid arthritis schizophrenia skin disease stomach cancer systemic lupus erythematosus thrombocytopenia toxic shock syndrome trachoma type 2 diabetes mellitus uveitis	DOID:0050589 DOID:0050866 DOID:0060901 DOID:0080547 DOID:0081120 DOID:0081267 DOID:10459 DOID:10534 DOID:10652 DOID:10754 DOID:11265 DOID:12030 DOID:12132 DOID:12134 DOID:12361 DOID:12894 DOID:13141 DOID:13241 DOID:14115 DOID:1417 DOID:1470 DOID:1474 DOID:1588 DOID:1793 DOID:1883 DOID:2043 DOID:219 DOID:2349 DOID:2841 DOID:2862 DOID:2913 DOID:3070 DOID:3234 DOID:3393 DOID:37 DOID:4948 DOID:5082 DOID:526 DOID:5419 DOID:5844 DOID:684 DOID:686 DOID:7148 DOID:8483 DOID:8552 DOID:8778 DOID:8893 DOID:8924 DOID:8947 DOID:9074 DOID:9352 DOID:9538 DOID:9663	B cell activation B cell differentiation B cell proliferation anatomical structure development anatomical structure morphogenesis animal organ development animal organ regeneration apoptotic process binding biological process involved in interspecies interaction between organisms biological regulation biological_process branching involved in labyrinthine layer morphogenesis cell activation cell chemotaxis cell death cell development cell differentiation cell migration cell motility cell population proliferation cell surface receptor signaling pathway cellular anatomical entity cellular developmental process cellular process cellular response to biotic stimulus cellular response to chemical stimulus cellular response to endogenous stimulus cellular response to estradiol stimulus cellular response to growth factor stimulus cellular response to hepatocyte growth factor stimulus cellular response to lipid cellular response to lipopolysaccharide cellular response to molecule of bacterial origin cellular response to organic cyclic compound cellular response to organic substance cellular response to oxygen-containing compound cellular response to stimulus cellular_component chemotaxis chronic inflammatory response to antigenic stimulus chronic inflammatory response cytokine activity cytokine receptor binding cytokine-mediated signaling pathway cytoplasmic sequestering of NF-kappaB cytoplasmic sequestering of protein cytoplasmic sequestering of transcription factor defense response to bacterium defense response to other organism defense response to protozoan defense response developmental process embryonic morphogenesis endothelial cell apoptotic process epithelial cell apoptotic process extracellular region extracellular space gland development growth factor activity growth factor receptor binding hemopoiesis immune response immune system process inflammatory response to antigenic stimulus inflammatory response interleukin-10 receptor binding interleukin-10-mediated signaling pathway leukocyte activation leukocyte chemotaxis leukocyte differentiation leukocyte migration leukocyte proliferation liver development liver regeneration localization locomotion lymphocyte activation lymphocyte differentiation lymphocyte proliferation maintenance of location maintenance of protein location molecular function activator activity molecular function regulator activity molecular_function mononuclear cell differentiation mononuclear cell proliferation morphogenesis of a branching epithelium morphogenesis of a branching structure morphogenesis of an epithelium multicellular organismal process negative regulation of B cell activation negative regulation of B cell proliferation negative regulation of DNA-binding transcription factor activity negative regulation of MHC class II biosynthetic process negative regulation of NF-kappaB transcription factor activity negative regulation of T cell activation negative regulation of T cell proliferation negative regulation of apoptotic process negative regulation of apoptotic signaling pathway negative regulation of autophagy negative regulation of binding negative regulation of biological process negative regulation of biosynthetic process negative regulation of catabolic process negative regulation of cell activation negative regulation of cell adhesion negative regulation of cell communication negative regulation of cell cycle negative regulation of cell population proliferation negative regulation of cell-cell adhesion negative regulation of cellular biosynthetic process negative regulation of cellular catabolic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of chemokine (C-C motif) ligand 5 production negative regulation of chemokine production negative regulation of chronic inflammatory response to antigenic stimulus negative regulation of chronic inflammatory response negative regulation of cytokine activity negative regulation of cytokine production involved in immune response negative regulation of cytokine production negative regulation of defense response negative regulation of endothelial cell apoptotic process negative regulation of epithelial cell apoptotic process negative regulation of gene expression negative regulation of heterotypic cell-cell adhesion negative regulation of immune effector process negative regulation of immune response negative regulation of immune system process negative regulation of inflammatory response to antigenic stimulus negative regulation of inflammatory response negative regulation of interferon-alpha production negative regulation of interleukin-1 production negative regulation of interleukin-12 production negative regulation of interleukin-18 production negative regulation of interleukin-6 production negative regulation of interleukin-8 production negative regulation of intracellular signal transduction negative regulation of intrinsic apoptotic signaling pathway negative regulation of leukocyte activation negative regulation of leukocyte cell-cell adhesion negative regulation of leukocyte proliferation negative regulation of lymphocyte activation negative regulation of lymphocyte proliferation negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of membrane protein ectodomain proteolysis negative regulation of metabolic process negative regulation of mitotic cell cycle negative regulation of molecular function negative regulation of mononuclear cell proliferation negative regulation of multicellular organismal process negative regulation of myeloid dendritic cell activation negative regulation of neuron apoptotic process negative regulation of nitric oxide biosynthetic process negative regulation of nitric oxide metabolic process negative regulation of nitrogen compound metabolic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of production of molecular mediator of immune response negative regulation of programmed cell death negative regulation of protein binding negative regulation of protein catabolic process negative regulation of protein metabolic process negative regulation of proteolysis negative regulation of receptor binding negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of smooth muscle cell proliferation negative regulation of tumor necrosis factor production negative regulation of tumor necrosis factor superfamily cytokine production negative regulation of type I interferon production negative regulation of type II interferon production negative regulation of vascular associated smooth muscle cell proliferation positive regulation of B cell activation positive regulation of B cell apoptotic process positive regulation of B cell differentiation positive regulation of DNA-binding transcription factor activity positive regulation of DNA-templated transcription positive regulation of MHC class II biosynthetic process positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of angiogenesis positive regulation of apoptotic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell communication positive regulation of cell cycle positive regulation of cell development positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of developmental process positive regulation of endothelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of gene expression positive regulation of hemopoiesis positive regulation of heterotypic cell-cell adhesion positive regulation of immune effector process positive regulation of immune response positive regulation of immune system process positive regulation of immunoglobulin production positive regulation of leukocyte activation positive regulation of leukocyte apoptotic process positive regulation of leukocyte differentiation positive regulation of lymphocyte activation positive regulation of lymphocyte apoptotic process positive regulation of lymphocyte differentiation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of macrophage activation positive regulation of metabolic process positive regulation of miRNA metabolic process positive regulation of miRNA transcription positive regulation of molecular function positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of plasma cell differentiation positive regulation of production of molecular mediator of immune response positive regulation of programmed cell death positive regulation of receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via STAT positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling receptor activity positive regulation of signaling positive regulation of smooth muscle cell proliferation positive regulation of sprouting angiogenesis positive regulation of transcription by RNA polymerase II positive regulation of vascular associated smooth muscle cell proliferation positive regulation of vasculature development programmed cell death protein binding protein dimerization activity receptor ligand activity regeneration regulation of B cell activation regulation of B cell apoptotic process regulation of B cell differentiation regulation of B cell mediated immunity regulation of B cell proliferation regulation of DNA metabolic process regulation of DNA recombination regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of MHC class II biosynthetic process regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of T cell activation regulation of T cell proliferation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of anatomical structure morphogenesis regulation of angiogenesis regulation of apoptotic process regulation of apoptotic signaling pathway regulation of autophagy regulation of binding regulation of biological process regulation of biosynthetic process regulation of catabolic process regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell cycle regulation of cell development regulation of cell differentiation regulation of cell killing regulation of cell population proliferation regulation of cell-cell adhesion involved in gastrulation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular catabolic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of chemokine (C-C motif) ligand 5 production regulation of chemokine production regulation of chronic inflammatory response to antigenic stimulus regulation of chronic inflammatory response regulation of complement-dependent cytotoxicity regulation of cytokine activity regulation of cytokine production involved in immune response regulation of cytokine production regulation of defense response regulation of developmental process regulation of endothelial cell apoptotic process regulation of endothelial cell proliferation regulation of epithelial cell apoptotic process regulation of epithelial cell proliferation regulation of gene expression regulation of hemopoiesis regulation of heterotypic cell-cell adhesion regulation of immune effector process regulation of immune response regulation of immune system process regulation of immunoglobulin mediated immune response regulation of immunoglobulin production regulation of inflammatory response to antigenic stimulus regulation of inflammatory response regulation of interferon-alpha production regulation of interleukin-1 production regulation of interleukin-12 production regulation of interleukin-18 production regulation of interleukin-6 production regulation of interleukin-8 production regulation of intracellular signal transduction regulation of intrinsic apoptotic signaling pathway regulation of isotype switching regulation of leukocyte activation regulation of leukocyte apoptotic process regulation of leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of leukocyte mediated immunity regulation of leukocyte proliferation regulation of lymphocyte activation regulation of lymphocyte apoptotic process regulation of lymphocyte differentiation regulation of lymphocyte mediated immunity regulation of lymphocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of macrophage activation regulation of membrane protein ectodomain proteolysis regulation of metabolic process regulation of miRNA metabolic process regulation of miRNA transcription regulation of mitotic cell cycle regulation of molecular function regulation of mononuclear cell proliferation regulation of multicellular organismal development regulation of multicellular organismal process regulation of myeloid dendritic cell activation regulation of ncRNA transcription regulation of neuron apoptotic process regulation of nitric oxide biosynthetic process regulation of nitric oxide metabolic process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of plasma cell differentiation regulation of primary metabolic process regulation of production of molecular mediator of immune response regulation of programmed cell death regulation of protein binding regulation of protein catabolic process regulation of protein metabolic process regulation of proteolysis regulation of receptor binding regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of response to wounding regulation of signal transduction regulation of signaling receptor activity regulation of signaling regulation of smooth muscle cell proliferation regulation of sprouting angiogenesis regulation of synapse organization regulation of transcription by RNA polymerase II regulation of tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of type I interferon production regulation of type II interferon production regulation of vascular associated smooth muscle cell proliferation regulation of vasculature development response to activity response to bacterium response to biotic stimulus response to carbon monoxide response to chemical response to corticosteroid response to endogenous stimulus response to estradiol response to external biotic stimulus response to external stimulus response to glucocorticoid response to growth factor response to hepatocyte growth factor response to hormone response to inactivity response to insulin response to lipid response to lipopolysaccharide response to molecule of bacterial origin response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to other organism response to oxygen-containing compound response to peptide hormone response to peptide response to protozoan response to steroid hormone response to stimulus response to stress response to xenobiotic stimulus signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity taxis tissue morphogenesis type 2 immune response	GO:0000018 GO:0001562 GO:0001763 GO:0001775 GO:0001817 GO:0001818 GO:0001819 GO:0001889 GO:0001936 GO:0001938 GO:0002009 GO:0002237 GO:0002376 GO:0002437 GO:0002439 GO:0002521 GO:0002544 GO:0002637 GO:0002639 GO:0002676 GO:0002677 GO:0002682 GO:0002683 GO:0002684 GO:0002694 GO:0002695 GO:0002696 GO:0002697 GO:0002698 GO:0002699 GO:0002700 GO:0002701 GO:0002702 GO:0002703 GO:0002706 GO:0002712 GO:0002718 GO:0002719 GO:0002819 GO:0002822 GO:0002861 GO:0002862 GO:0002874 GO:0002875 GO:0002889 GO:0002902 GO:0002904 GO:0003674 GO:0005102 GO:0005125 GO:0005126 GO:0005141 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0006355 GO:0006357 GO:0006915 GO:0006935 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0007162 GO:0007165 GO:0007166 GO:0007253 GO:0007346 GO:0008083 GO:0008150 GO:0008219 GO:0008283 GO:0008284 GO:0008285 GO:0009410 GO:0009605 GO:0009607 GO:0009617 GO:0009653 GO:0009719 GO:0009725 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009894 GO:0009895 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010033 GO:0010243 GO:0010468 GO:0010469 GO:0010506 GO:0010507 GO:0010556 GO:0010557 GO:0010558 GO:0010604 GO:0010605 GO:0010628 GO:0010629 GO:0010646 GO:0010647 GO:0010648 GO:0010720 GO:0012501 GO:0014070 GO:0014823 GO:0014854 GO:0016477 GO:0019219 GO:0019221 GO:0019222 GO:0022407 GO:0022408 GO:0022409 GO:0022603 GO:0023051 GO:0023056 GO:0023057 GO:0030097 GO:0030098 GO:0030154 GO:0030155 GO:0030162 GO:0030183 GO:0030545 GO:0030546 GO:0030595 GO:0030885 GO:0030886 GO:0030888 GO:0030889 GO:0031099 GO:0031100 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031329 GO:0031330 GO:0031341 GO:0031347 GO:0031348 GO:0031960 GO:0032088 GO:0032091 GO:0032101 GO:0032102 GO:0032355 GO:0032479 GO:0032480 GO:0032496 GO:0032501 GO:0032502 GO:0032642 GO:0032647 GO:0032649 GO:0032652 GO:0032655 GO:0032661 GO:0032675 GO:0032677 GO:0032680 GO:0032682 GO:0032687 GO:0032689 GO:0032692 GO:0032695 GO:0032701 GO:0032715 GO:0032717 GO:0032720 GO:0032868 GO:0032943 GO:0032944 GO:0032945 GO:0033993 GO:0034114 GO:0034115 GO:0034116 GO:0034465 GO:0035728 GO:0035729 GO:0040011 GO:0042092 GO:0042100 GO:0042113 GO:0042127 GO:0042129 GO:0042130 GO:0042176 GO:0042177 GO:0042221 GO:0042330 GO:0042742 GO:0042832 GO:0042981 GO:0042994 GO:0043030 GO:0043032 GO:0043065 GO:0043066 GO:0043067 GO:0043068 GO:0043069 GO:0043207 GO:0043393 GO:0043433 GO:0043434 GO:0043523 GO:0043524 GO:0044092 GO:0044093 GO:0044419 GO:0045019 GO:0045185 GO:0045191 GO:0045321 GO:0045346 GO:0045347 GO:0045348 GO:0045428 GO:0045577 GO:0045579 GO:0045595 GO:0045597 GO:0045619 GO:0045621 GO:0045765 GO:0045766 GO:0045785 GO:0045786 GO:0045787 GO:0045861 GO:0045893 GO:0045930 GO:0045935 GO:0045944 GO:0046425 GO:0046427 GO:0046649 GO:0046651 GO:0046983 GO:0048018 GO:0048468 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048545 GO:0048583 GO:0048584 GO:0048585 GO:0048598 GO:0048660 GO:0048661 GO:0048662 GO:0048729 GO:0048732 GO:0048856 GO:0048869 GO:0048870 GO:0050670 GO:0050672 GO:0050678 GO:0050679 GO:0050727 GO:0050728 GO:0050776 GO:0050777 GO:0050778 GO:0050789 GO:0050793 GO:0050794 GO:0050807 GO:0050863 GO:0050864 GO:0050865 GO:0050866 GO:0050867 GO:0050868 GO:0050869 GO:0050871 GO:0050896 GO:0050900 GO:0051043 GO:0051045 GO:0051052 GO:0051090 GO:0051091 GO:0051094 GO:0051098 GO:0051100 GO:0051128 GO:0051171 GO:0051172 GO:0051173 GO:0051179 GO:0051220 GO:0051235 GO:0051239 GO:0051240 GO:0051241 GO:0051246 GO:0051248 GO:0051249 GO:0051250 GO:0051251 GO:0051252 GO:0051254 GO:0051384 GO:0051707 GO:0051716 GO:0051726 GO:0060255 GO:0060284 GO:0060300 GO:0060302 GO:0060326 GO:0060670 GO:0061138 GO:0065007 GO:0065009 GO:0070228 GO:0070230 GO:0070587 GO:0070661 GO:0070663 GO:0070664 GO:0070848 GO:0070851 GO:0070887 GO:0071216 GO:0071219 GO:0071222 GO:0071310 GO:0071363 GO:0071392 GO:0071396 GO:0071407 GO:0071495 GO:0071649 GO:0071650 GO:0072577 GO:0080090 GO:0080134 GO:0080164 GO:0097421 GO:0098542 GO:0098772 GO:0110165 GO:0140105 GO:0140677 GO:0140747 GO:1900098 GO:1900100 GO:1900120 GO:1900121 GO:1901342 GO:1901652 GO:1901698 GO:1901700 GO:1901701 GO:1902105 GO:1902107 GO:1902175 GO:1902176 GO:1902531 GO:1902532 GO:1902680 GO:1902893 GO:1902895 GO:1903034 GO:1903037 GO:1903038 GO:1903131 GO:1903376 GO:1903377 GO:1903555 GO:1903556 GO:1903659 GO:1903670 GO:1903672 GO:1903706 GO:1903708 GO:1904018 GO:1904019 GO:1904035 GO:1904036 GO:1904406 GO:1904705 GO:1904706 GO:1904707 GO:1904892 GO:1904894 GO:2000026 GO:2000106 GO:2000108 GO:2000273 GO:2000351 GO:2000352 GO:2000628 GO:2000630 GO:2001141 GO:2001233 GO:2001234 GO:2001242 GO:2001243
3587	interleukin 10 receptor subunit alpha	IL10RA	Homo sapiens (human)	9606	inflammatory bowel disease 28	DOID:0110899	anatomical structure homeostasis apical plasma membrane binding biological regulation biological_process cell projection cell surface receptor signaling pathway cellular anatomical entity cellular localization cellular macromolecule localization cellular process cellular_component cilium cytokine binding cytokine receptor activity cytokine-mediated signaling pathway cytosol digestive system process endocytosis epithelial structure maintenance establishment of localization establishment of protein localization to organelle establishment of protein localization growth factor binding homeostatic process immune receptor activity import into cell interleukin-10 binding interleukin-10 receptor activity interleukin-10-mediated signaling pathway intestinal epithelial structure maintenance localization macromolecule localization maintenance of gastrointestinal epithelium membrane-bounded organelle membrane molecular transducer activity molecular_function multicellular organismal process multicellular organismal-level homeostasis negative regulation of autophagy negative regulation of biological process negative regulation of catabolic process negative regulation of cellular catabolic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of defense response negative regulation of inflammatory response negative regulation of metabolic process negative regulation of response to external stimulus negative regulation of response to stimulus nitrogen compound transport nucleoplasm organelle organic substance transport plasma membrane bounded cell projection plasma membrane region plasma membrane positive regulation of biological process positive regulation of cell communication positive regulation of cellular process positive regulation of receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via STAT positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling protein binding protein localization to organelle protein localization protein transport regulation of autophagy regulation of biological process regulation of catabolic process regulation of cell communication regulation of cellular catabolic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of defense response regulation of inflammatory response regulation of metabolic process regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of signal transduction regulation of signaling regulation of synapse organization response to biotic stimulus response to chemical response to external biotic stimulus response to external stimulus response to lipid response to lipopolysaccharide response to molecule of bacterial origin response to organic substance response to oxygen-containing compound response to stimulus signal transduction signaling receptor activity system process tissue homeostasis transmembrane signaling receptor activity transport ubiquitin-dependent endocytosis vesicle-mediated transport	GO:0001894 GO:0002237 GO:0003008 GO:0003674 GO:0004888 GO:0004896 GO:0004920 GO:0005488 GO:0005515 GO:0005575 GO:0005654 GO:0005829 GO:0005886 GO:0005929 GO:0006810 GO:0006897 GO:0007165 GO:0007166 GO:0008104 GO:0008150 GO:0009605 GO:0009607 GO:0009892 GO:0009894 GO:0009895 GO:0009966 GO:0009967 GO:0009987 GO:0010033 GO:0010506 GO:0010507 GO:0010646 GO:0010647 GO:0010669 GO:0015031 GO:0016020 GO:0016192 GO:0016324 GO:0019221 GO:0019222 GO:0019838 GO:0019955 GO:0019969 GO:0022600 GO:0023051 GO:0023056 GO:0030277 GO:0031323 GO:0031324 GO:0031329 GO:0031330 GO:0031347 GO:0031348 GO:0032101 GO:0032102 GO:0032496 GO:0032501 GO:0033036 GO:0033365 GO:0033993 GO:0038023 GO:0042221 GO:0042592 GO:0042995 GO:0043207 GO:0043226 GO:0043227 GO:0045184 GO:0046425 GO:0046427 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048871 GO:0050727 GO:0050728 GO:0050789 GO:0050794 GO:0050807 GO:0050896 GO:0051128 GO:0051179 GO:0051234 GO:0051641 GO:0060089 GO:0060249 GO:0060729 GO:0065007 GO:0070086 GO:0070727 GO:0071702 GO:0071705 GO:0072594 GO:0080134 GO:0098590 GO:0098657 GO:0110165 GO:0120025 GO:0140105 GO:0140375 GO:1901700 GO:1904892 GO:1904894
3588	interleukin 10 receptor subunit beta	IL10RB	Homo sapiens (human)	9606	graft-versus-host disease hepatitis B inflammatory bowel disease 25	DOID:0081267 DOID:0110909 DOID:2043	binding biological process involved in interspecies interaction between organisms biological regulation biological_process cell surface receptor signaling pathway cellular anatomical entity cellular process cellular response to virus cellular_component coreceptor activity cytokine receptor activity cytokine-mediated signaling pathway defense response to other organism defense response to symbiont defense response to virus defense response immune receptor activity immune response immune system process inflammatory response interferon-mediated signaling pathway interleukin-10 receptor activity interleukin-10-mediated signaling pathway interleukin-28 receptor complex membrane protein complex membrane molecular transducer activity molecular_function plasma membrane protein complex plasma membrane signaling receptor complex plasma membrane positive regulation of biological process positive regulation of cell communication positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cellular respiration positive regulation of metabolic process positive regulation of receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via STAT positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling protein binding protein-containing complex receptor complex regulation of biological process regulation of cell communication regulation of cellular metabolic process regulation of cellular process regulation of cellular respiration regulation of generation of precursor metabolites and energy regulation of metabolic process regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT regulation of response to stimulus regulation of signal transduction regulation of signaling response to biotic stimulus response to external biotic stimulus response to external stimulus response to other organism response to stimulus response to stress response to virus signal transduction signaling receptor activity transmembrane signaling receptor activity type III interferon-mediated signaling pathway	GO:0002376 GO:0003674 GO:0004888 GO:0004896 GO:0004920 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0007165 GO:0007166 GO:0008150 GO:0009605 GO:0009607 GO:0009615 GO:0009893 GO:0009966 GO:0009967 GO:0009987 GO:0010646 GO:0010647 GO:0015026 GO:0016020 GO:0019221 GO:0019222 GO:0023051 GO:0023056 GO:0031323 GO:0031325 GO:0032002 GO:0032991 GO:0038023 GO:0038196 GO:0043207 GO:0043235 GO:0043457 GO:0043467 GO:0044419 GO:0046425 GO:0046427 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0050789 GO:0050794 GO:0050896 GO:0051607 GO:0051707 GO:0060089 GO:0065007 GO:0098542 GO:0098586 GO:0098796 GO:0098797 GO:0098802 GO:0110165 GO:0140105 GO:0140375 GO:0140546 GO:0140888 GO:1901857 GO:1904892 GO:1904894

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