GlyCosmos Portal

GlyCosmos Genes

Integrated list of glycan-related genes extracted KEGG GENES Database, UniProt, GlycoGene Database (GGDB), Plant GARDEN and FlyGlycoDB. Glycan-related genes including glycosyltransferase, hydrolase activity (acting on glycosyl bonds), carbohydrate metabolic process, etc .

Source	Last Updated
FlyGlycoDB	March 25, 2024
GlycoGene Database (GGDB)	January 26, 2018
KEGG GENES Database	September 20, 2023
Plant GARDEN	May 28, 2020
UniProt	October 29, 2024

Selecting the function you want to look up from the categories displays a list narrowed down to glycan-related genes with that function (Gene Ontology).

Catalytic activity

glycosyltransferase activity

hydrolase activity, acting on glycosyl bonds

Binding

carbohydrate binding

Response to carbohydrate

Primary metabolic process

Displaying entries **1 - 25** of **9988** in total

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Gene ID	Gene Name ▲	Gene Symbol	Organism	Taxonomy ID	Disease Ontology	Disease Ontology ID	Gene Ontology	Gene Ontology ID
2632	1,4-alpha-glucan branching enzyme 1	GBE1 Aliases: Andersen disease glycogen branching enzyme glycogen storage disease type IV	Homo sapiens (human)	9606	B-cell lymphoma Cauda equina syndrome Fabry disease Gerstmann-Straussler-Scheinker syndrome Gorham's disease Guillain-Barre syndrome Noonan syndrome 1 acute myeloid leukemia bronchus cancer bronchus carcinoma cancer cardiomyopathy carnitine palmitoyltransferase II deficiency cerebral infarction cerebrovascular disease chronic inflammatory demyelinating polyneuritis chronic inflammatory demyelinating polyradiculoneuropathy chronic ulcer of skin chylomicron retention disease congenital merosin-deficient muscular dystrophy 1A congenital muscular dystrophy 1B congenital muscular dystrophy due to LMNA mutation congenital muscular dystrophy due to integrin alpha-7 deficiency congenital myopathy 1A congestive heart failure contractures, pterygia, and spondylocarpotarsal fusion syndrome cystinuria cytochrome-c oxidase deficiency disease dementia diabetes mellitus diabetic ketoacidosis dilated cardiomyopathy 1A dilated cardiomyopathy disease of metabolism embryoma endomyocardial fibrosis esophagus squamous cell carcinoma familial lipoprotein lipase deficiency familial periodic paralysis fetal akinesia deformation sequence syndrome 1 fetal akinesia deformation sequence syndrome galactosemia gallbladder disease glucosephosphate dehydrogenase deficiency glycogen storage disease II glycogen storage disease III glycogen storage disease IV glycogen storage disease IXa glycogen storage disease IXb glycogen storage disease IXc glycogen storage disease IXd glycogen storage disease Ia glycogen storage disease VI glycogen storage disease VII glycogen storage disease hypertrophic cardiomyopathy idiopathic scoliosis intellectual disability learning disability leukodystrophy lipid storage disease liver disease locked-in syndrome lung adenocarcinoma lung benign neoplasm lung cancer lung carcinoma megaconial type congenital muscular dystrophy melanoma mitochondrial metabolism disease mitochondrial myopathy mitochondrial trifunctional protein deficiency multiple sclerosis muscular dystrophy-dystroglycanopathy type B1 muscular dystrophy-dystroglycanopathy type B5 muscular dystrophy-dystroglycanopathy type B6 myopathy nemaline myopathy neurogenic bladder obsolete ymphosarcoma ovarian cancer ovarian carcinoma paraplegia polyhydramnios porphyria portal hypertension pulmonary tuberculosis quadriplegia rigid spine muscular dystrophy 1 skin melanoma	DOID:0014667 DOID:0050588 DOID:0050700 DOID:0060235 DOID:0060250 DOID:0060262 DOID:0060357 DOID:0060578 DOID:0080110 DOID:0110425 DOID:0110632 DOID:0110633 DOID:0110634 DOID:0110635 DOID:0110636 DOID:0110637 DOID:0110639 DOID:0110640 DOID:0111040 DOID:0111041 DOID:0111042 DOID:0111043 DOID:0111277 DOID:0111375 DOID:0111377 DOID:1029 DOID:10579 DOID:1059 DOID:10762 DOID:11577 DOID:11721 DOID:11984 DOID:12143 DOID:12697 DOID:12835 DOID:12842 DOID:12930 DOID:12932 DOID:1307 DOID:1324 DOID:1325 DOID:13268 DOID:14118 DOID:14499 DOID:162 DOID:1837 DOID:1909 DOID:2377 DOID:2394 DOID:2536 DOID:2747 DOID:2748 DOID:2749 DOID:2750 DOID:2752 DOID:2754 DOID:2862 DOID:2957 DOID:3191 DOID:3526 DOID:3529 DOID:3683 DOID:3748 DOID:3762 DOID:3904 DOID:3905 DOID:3910 DOID:4001 DOID:409 DOID:423 DOID:4249 DOID:4766 DOID:4837 DOID:5213 DOID:6000 DOID:607 DOID:6713 DOID:699 DOID:700 DOID:707 DOID:8488 DOID:8549 DOID:8675 DOID:8923 DOID:8927 DOID:9119 DOID:9266 DOID:9351 DOID:9455 DOID:9870	1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) 1,4-alpha-glucan branching enzyme activity binding biological regulation biological_process biosynthetic process carbohydrate binding carbohydrate biosynthetic process carbohydrate metabolic process catalytic activity cation binding cellular anatomical entity cellular biosynthetic process cellular metabolic process cellular process cellular_component cytoplasm cytosol energy derivation by oxidation of organic compounds energy reserve metabolic process extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle generation of precursor metabolites and energy glucan biosynthetic process glucan metabolic process glycogen biosynthetic process glycogen metabolic process glycosyltransferase activity hexosyltransferase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity ion binding macromolecule biosynthetic process macromolecule metabolic process membrane-bounded organelle metabolic process molecular_function negative regulation of apoptotic process negative regulation of biological process negative regulation of cellular process negative regulation of neuron apoptotic process negative regulation of programmed cell death organelle organic substance biosynthetic process organic substance metabolic process polysaccharide biosynthetic process polysaccharide metabolic process primary metabolic process protein binding regulation of apoptotic process regulation of biological process regulation of cellular process regulation of neuron apoptotic process regulation of programmed cell death transferase activity vesicle	GO:0000271 GO:0003674 GO:0003824 GO:0003844 GO:0004553 GO:0005488 GO:0005515 GO:0005575 GO:0005737 GO:0005829 GO:0005975 GO:0005976 GO:0005977 GO:0005978 GO:0006091 GO:0006112 GO:0008150 GO:0008152 GO:0009058 GO:0009059 GO:0009250 GO:0009987 GO:0015980 GO:0016051 GO:0016740 GO:0016757 GO:0016758 GO:0016787 GO:0016798 GO:0030246 GO:0031982 GO:0042981 GO:0043066 GO:0043067 GO:0043069 GO:0043167 GO:0043169 GO:0043170 GO:0043226 GO:0043227 GO:0043230 GO:0043523 GO:0043524 GO:0044042 GO:0044237 GO:0044238 GO:0044249 GO:0048519 GO:0048523 GO:0050789 GO:0050794 GO:0065007 GO:0065010 GO:0070062 GO:0071704 GO:0102752 GO:0110165 GO:1901576 GO:1903561
10554	1-acylglycerol-3-phosphate O-acyltransferase 1	AGPAT1 Aliases: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha LPAAT-alpha LPLAT1 lysophosphatidic acid acyltransferase, alpha lysophospholipid acyltransferase l	Homo sapiens (human)	9606	Japanese encephalitis cancer congenital generalized lipodystrophy type 1 congenital generalized lipodystrophy type 2 congenital generalized lipodystrophy type 3 congenital generalized lipodystrophy type 4 dengue disease diabetic ketoacidosis embryoma lipoatrophic diabetes mellitus lipodystrophy obsolete type 1 diabetes mellitus 9 pancreatic cancer pancreatic carcinoma rheumatoid arthritis steatotic liver disease type 1 diabetes mellitus 10 type 1 diabetes mellitus 11 type 1 diabetes mellitus 12 type 1 diabetes mellitus 13 type 1 diabetes mellitus 15 type 1 diabetes mellitus 17 type 1 diabetes mellitus 18 type 1 diabetes mellitus 19 type 1 diabetes mellitus 20 type 1 diabetes mellitus 21 type 1 diabetes mellitus 22 type 1 diabetes mellitus 23 type 1 diabetes mellitus 24 type 1 diabetes mellitus 2 type 1 diabetes mellitus 3 type 1 diabetes mellitus 4 type 1 diabetes mellitus 5 type 1 diabetes mellitus 6 type 1 diabetes mellitus 7 type 1 diabetes mellitus 8 type 1 diabetes mellitus viral infectious disease yellow fever	DOID:0110741 DOID:0110742 DOID:0110743 DOID:0110744 DOID:0110745 DOID:0110746 DOID:0110747 DOID:0110748 DOID:0110749 DOID:0110750 DOID:0110751 DOID:0110752 DOID:0110753 DOID:0110754 DOID:0110755 DOID:0110756 DOID:0110757 DOID:0110758 DOID:0110759 DOID:0110760 DOID:0110761 DOID:0111135 DOID:0111136 DOID:0111137 DOID:0111138 DOID:10844 DOID:11712 DOID:12205 DOID:162 DOID:1793 DOID:1837 DOID:4766 DOID:4905 DOID:7148 DOID:811 DOID:934 DOID:9452 DOID:9682 DOID:9744	1-acylglycerol-3-phosphate O-acyltransferase activity CDP-diacylglycerol biosynthetic process CDP-diacylglycerol metabolic process O-acyltransferase activity acylglycerol O-acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups acyltransferase activity binding biological regulation biological_process biosynthetic process catalytic activity cellular anatomical entity cellular biosynthetic process cellular lipid metabolic process cellular metabolic process cellular process cellular_component endoplasmic reticulum membrane endoplasmic reticulum glycerolipid biosynthetic process glycerolipid metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process intracellular membrane-bounded organelle intracellular organelle lipid biosynthetic process lipid metabolic process lysophosphatidic acid acyltransferase activity lysophospholipid acyltransferase activity membrane-bounded organelle membrane metabolic process molecular_function organelle membrane organelle organic substance biosynthetic process organic substance metabolic process organophosphate biosynthetic process organophosphate metabolic process phosphate-containing compound metabolic process phosphatidic acid biosynthetic process phosphatidic acid metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphorus metabolic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell communication positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of cytokine-mediated signaling pathway positive regulation of gene expression positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of response to cytokine stimulus positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling primary metabolic process protein binding regulation of biological process regulation of biosynthetic process regulation of cell communication regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cytokine production regulation of cytokine-mediated signaling pathway regulation of gene expression regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process regulation of response to cytokine stimulus regulation of response to stimulus regulation of signal transduction regulation of signaling transferase activity	GO:0001817 GO:0001819 GO:0001959 GO:0001961 GO:0003674 GO:0003824 GO:0003841 GO:0005488 GO:0005515 GO:0005575 GO:0005783 GO:0005789 GO:0006629 GO:0006644 GO:0006650 GO:0006654 GO:0006793 GO:0006796 GO:0008150 GO:0008152 GO:0008374 GO:0008610 GO:0008654 GO:0009058 GO:0009889 GO:0009891 GO:0009893 GO:0009966 GO:0009967 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0010646 GO:0010647 GO:0016020 GO:0016024 GO:0016411 GO:0016740 GO:0016746 GO:0016747 GO:0019222 GO:0019637 GO:0023051 GO:0023056 GO:0031090 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0042171 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0045017 GO:0046341 GO:0046473 GO:0046474 GO:0046486 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0050789 GO:0050794 GO:0051239 GO:0051240 GO:0060255 GO:0060759 GO:0060760 GO:0065007 GO:0071617 GO:0071704 GO:0090407 GO:0110165 GO:1901576
10555	1-acylglycerol-3-phosphate O-acyltransferase 2	AGPAT2 Aliases: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta LPAAT-beta LPLAT2 lysophosphatidic acid acyltransferase-beta lysophospholipid acyltransferase 2	Homo sapiens (human)	9606	Fanconi syndrome Zollinger-Ellison syndrome acanthosis nigricans acute myocardial infarction acute pancreatitis acute promyelocytic leukemia aromatase excess syndrome arteriolosclerosis arteriosclerosis arteriosclerotic cardiovascular disease atherosclerosis atrial fibrillation atrichia with papular lesions bone osteosarcoma bulimia nervosa cancer cardiomyopathy childhood osteosarcoma chronic myeloid leukemia congenital generalized lipodystrophy type 1 congenital generalized lipodystrophy type 2 congenital generalized lipodystrophy type 3 congenital generalized lipodystrophy type 4 congenital generalized lipodystrophy congestive heart failure coronary artery disease coronary thrombosis cystinosis diabetes mellitus diabetic ketoacidosis embryoma endometrial cancer endometrial carcinoma endomyocardial fibrosis familial hypertrophic cardiomyopathy familial partial lipodystrophy familial periodic paralysis glomerulonephritis hydrocephalus hyperinsulinism hypertrichosis hypertrophic cardiomyopathy intellectual disability isolated growth hormone deficiency kidney disease kidney failure learning disability lipoatrophic diabetes mellitus lipodystrophy myocardial infarction myopathy neonatal diabetes nephritis nephrolithiasis nephrosis neuropathy obesity omphalocele osteoporosis osteosarcoma ovarian cancer ovarian carcinoma pancreatic adenocarcinoma pancreatitis peripheral nervous system disease polycystic ovary syndrome primary immunodeficiency disease primary pulmonary hypertension pyloric stenosis pyoureter scoliosis silent myocardial infarction steatotic liver disease transient neonatal diabetes mellitus trichohepatoenteric syndrome 1 trichohepatoenteric syndrome type 2 diabetes mellitus umbilical hernia uric acid nephrolithiasis uterine corpus cancer	DOID:0050440 DOID:0050585 DOID:0050700 DOID:0050782 DOID:0060224 DOID:0060249 DOID:0060318 DOID:0060321 DOID:0060327 DOID:0060334 DOID:0060689 DOID:0060870 DOID:0080326 DOID:0090122 DOID:0111135 DOID:0111136 DOID:0111137 DOID:0111138 DOID:0111414 DOID:0111415 DOID:1029 DOID:1059 DOID:1062 DOID:1064 DOID:1074 DOID:10908 DOID:10952 DOID:11476 DOID:11612 DOID:11712 DOID:11717 DOID:11847 DOID:11984 DOID:12129 DOID:12639 DOID:12932 DOID:1380 DOID:1425 DOID:14557 DOID:162 DOID:1837 DOID:1936 DOID:2018 DOID:2348 DOID:2349 DOID:2394 DOID:2527 DOID:2871 DOID:2913 DOID:2921 DOID:3138 DOID:3347 DOID:3361 DOID:3376 DOID:3393 DOID:4001 DOID:4074 DOID:420 DOID:423 DOID:4766 DOID:4989 DOID:5162 DOID:557 DOID:574 DOID:580 DOID:5844 DOID:585 DOID:5854 DOID:6000 DOID:612 DOID:811 DOID:8552 DOID:870 DOID:8927 DOID:9351 DOID:9352 DOID:9408 DOID:9452 DOID:9460 DOID:9970	1-acylglycerol-3-phosphate O-acyltransferase activity CDP-diacylglycerol biosynthetic process CDP-diacylglycerol metabolic process O-acyltransferase activity acylglycerol O-acyltransferase activity acylglycerol biosynthetic process acylglycerol metabolic process acyltransferase activity, transferring groups other than amino-acyl groups acyltransferase activity anatomical structure development biological regulation biological_process biosynthetic process bounding membrane of organelle catalytic activity cellular anatomical entity cellular biosynthetic process cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytoplasmic vesicle membrane developmental process endoplasmic reticulum membrane endoplasmic reticulum epidermis development glycerolipid biosynthetic process glycerolipid metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process intracellular membrane-bounded organelle intracellular organelle lipid biosynthetic process lipid metabolic process lysophosphatidic acid acyltransferase activity lysophospholipid acyltransferase activity membrane-bounded organelle membrane metabolic process molecular_function neutral lipid biosynthetic process neutral lipid metabolic process organelle membrane organelle organic substance biosynthetic process organic substance metabolic process organophosphate biosynthetic process organophosphate metabolic process phosphate-containing compound metabolic process phosphatidic acid biosynthetic process phosphatidic acid metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphorus metabolic process plasma membrane positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell communication positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of cytokine-mediated signaling pathway positive regulation of gene expression positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of response to cytokine stimulus positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling primary metabolic process regulation of biological process regulation of biosynthetic process regulation of cell communication regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cytokine production regulation of cytokine-mediated signaling pathway regulation of gene expression regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process regulation of response to cytokine stimulus regulation of response to stimulus regulation of signal transduction regulation of signaling response to chemical response to stimulus response to xenobiotic stimulus secretory granule membrane specific granule membrane tissue development transferase activity triglyceride biosynthetic process triglyceride metabolic process vesicle membrane	GO:0001817 GO:0001819 GO:0001959 GO:0001961 GO:0003674 GO:0003824 GO:0003841 GO:0005575 GO:0005783 GO:0005789 GO:0005886 GO:0006629 GO:0006638 GO:0006639 GO:0006641 GO:0006644 GO:0006650 GO:0006654 GO:0006793 GO:0006796 GO:0008150 GO:0008152 GO:0008374 GO:0008544 GO:0008610 GO:0008654 GO:0009058 GO:0009410 GO:0009888 GO:0009889 GO:0009891 GO:0009893 GO:0009966 GO:0009967 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0010646 GO:0010647 GO:0012506 GO:0016020 GO:0016024 GO:0016411 GO:0016740 GO:0016746 GO:0016747 GO:0019222 GO:0019432 GO:0019637 GO:0023051 GO:0023056 GO:0030659 GO:0030667 GO:0031090 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0032502 GO:0035579 GO:0042171 GO:0042221 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0045017 GO:0046341 GO:0046460 GO:0046463 GO:0046473 GO:0046474 GO:0046486 GO:0048518 GO:0048522 GO:0048583 GO:0048584 GO:0048856 GO:0050789 GO:0050794 GO:0050896 GO:0051239 GO:0051240 GO:0060255 GO:0060759 GO:0060760 GO:0065007 GO:0071617 GO:0071704 GO:0090407 GO:0098588 GO:0110165 GO:1901576
56894	1-acylglycerol-3-phosphate O-acyltransferase 3	AGPAT3 Aliases: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma LPAAT-gamma LPAAT3 LPLAT3 lysophosphatidic acid acyltransferase gamma lysophospholipid acyltransferase 3	Homo sapiens (human)	9606	chronic obstructive pulmonary disease neurodegenerative disease	DOID:1289 DOID:3083	1-acylglycerol-3-phosphate O-acyltransferase activity CDP-diacylglycerol biosynthetic process CDP-diacylglycerol metabolic process Golgi membrane O-acyltransferase activity acylglycerol O-acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups acyltransferase activity binding biological_process biosynthetic process bounding membrane of organelle catalytic activity cellular anatomical entity cellular biosynthetic process cellular lipid metabolic process cellular metabolic process cellular process cellular_component endomembrane system endoplasmic reticulum membrane endoplasmic reticulum envelope glycerolipid biosynthetic process glycerolipid metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process intracellular membrane-bounded organelle intracellular organelle lipid biosynthetic process lipid metabolic process lysophosphatidic acid acyltransferase activity lysophospholipid acyltransferase activity membrane-bounded organelle membrane metabolic process molecular_function nuclear envelope organelle envelope organelle membrane organelle organic substance biosynthetic process organic substance metabolic process organophosphate biosynthetic process organophosphate metabolic process phosphate-containing compound metabolic process phosphatidic acid biosynthetic process phosphatidic acid metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphorus metabolic process plasma membrane primary metabolic process protein binding transferase activity	GO:0000139 GO:0003674 GO:0003824 GO:0003841 GO:0005488 GO:0005515 GO:0005575 GO:0005635 GO:0005783 GO:0005789 GO:0005886 GO:0006629 GO:0006644 GO:0006650 GO:0006654 GO:0006793 GO:0006796 GO:0008150 GO:0008152 GO:0008374 GO:0008610 GO:0008654 GO:0009058 GO:0009987 GO:0012505 GO:0016020 GO:0016024 GO:0016411 GO:0016740 GO:0016746 GO:0016747 GO:0019637 GO:0031090 GO:0031967 GO:0031975 GO:0042171 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0045017 GO:0046341 GO:0046473 GO:0046474 GO:0046486 GO:0071617 GO:0071704 GO:0090407 GO:0098588 GO:0110165 GO:1901576
56895	1-acylglycerol-3-phosphate O-acyltransferase 4	AGPAT4 Aliases: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta LPAAT-delta LPAAT4 LPLAT4 dJ473J16.2 lysophosphatidic acid acyltransferase, delta lysophospholipid acyltransferase 4	Homo sapiens (human)	9606	bladder carcinoma urinary bladder cancer	DOID:11054 DOID:4007	1-acylglycerol-3-phosphate O-acyltransferase activity CDP-diacylglycerol biosynthetic process CDP-diacylglycerol metabolic process O-acyltransferase activity acylglycerol O-acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups acyltransferase activity binding biological_process biosynthetic process bounding membrane of organelle catalytic activity cellular anatomical entity cellular biosynthetic process cellular lipid metabolic process cellular metabolic process cellular process cellular_component endomembrane system endoplasmic reticulum membrane endoplasmic reticulum glycerolipid biosynthetic process glycerolipid metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process intracellular membrane-bounded organelle intracellular organelle lipid biosynthetic process lipid metabolic process lysophosphatidic acid acyltransferase activity lysophospholipid acyltransferase activity membrane-bounded organelle membrane metabolic process mitochondrial membrane mitochondrial outer membrane molecular_function organelle membrane organelle outer membrane organelle organic substance biosynthetic process organic substance metabolic process organophosphate biosynthetic process organophosphate metabolic process outer membrane phosphate-containing compound metabolic process phosphatidic acid biosynthetic process phosphatidic acid metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphorus metabolic process primary metabolic process protein binding transferase activity	GO:0003674 GO:0003824 GO:0003841 GO:0005488 GO:0005515 GO:0005575 GO:0005741 GO:0005783 GO:0005789 GO:0006629 GO:0006644 GO:0006650 GO:0006654 GO:0006793 GO:0006796 GO:0008150 GO:0008152 GO:0008374 GO:0008610 GO:0008654 GO:0009058 GO:0009987 GO:0012505 GO:0016020 GO:0016024 GO:0016411 GO:0016740 GO:0016746 GO:0016747 GO:0019637 GO:0019867 GO:0031090 GO:0031966 GO:0031968 GO:0042171 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0045017 GO:0046341 GO:0046473 GO:0046474 GO:0046486 GO:0071617 GO:0071704 GO:0090407 GO:0098588 GO:0110165 GO:1901576
55326	1-acylglycerol-3-phosphate O-acyltransferase 5	AGPAT5 Aliases: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon FLJ11210 LPAAT-e LPAAT-epsilon LPLAT5 lysophosphatidic acid acyltransferase, epsilon lysophospholipid acyltransferase 5	Homo sapiens (human)	9606			1-acylglycerol-3-phosphate O-acyltransferase activity CDP-diacylglycerol biosynthetic process CDP-diacylglycerol metabolic process O-acyltransferase activity acylglycerol O-acyltransferase activity acylglycerol metabolic process acyltransferase activity, transferring groups other than amino-acyl groups acyltransferase activity binding biological_process biosynthetic process bounding membrane of organelle catalytic activity cell differentiation cellular anatomical entity cellular biosynthetic process cellular developmental process cellular lipid metabolic process cellular metabolic process cellular process cellular_component developmental process endomembrane system endoplasmic reticulum membrane endoplasmic reticulum envelope glycerolipid biosynthetic process glycerolipid metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process hematopoietic progenitor cell differentiation intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle lipid biosynthetic process lipid metabolic process lysophosphatidic acid acyltransferase activity lysophospholipid acyltransferase activity membrane-bounded organelle membrane metabolic process mitochondrial membrane mitochondrial outer membrane mitochondrion molecular_function neutral lipid metabolic process non-membrane-bounded organelle nuclear envelope nucleolus organelle envelope organelle membrane organelle outer membrane organelle organic substance biosynthetic process organic substance metabolic process organophosphate biosynthetic process organophosphate metabolic process outer membrane phosphate-containing compound metabolic process phosphatidic acid biosynthetic process phosphatidic acid metabolic process phosphatidylinositol acyl-chain remodeling phosphatidylinositol metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphorus metabolic process primary metabolic process protein binding transferase activity	GO:0002244 GO:0003674 GO:0003824 GO:0003841 GO:0005488 GO:0005515 GO:0005575 GO:0005635 GO:0005730 GO:0005739 GO:0005741 GO:0005783 GO:0005789 GO:0006629 GO:0006638 GO:0006639 GO:0006644 GO:0006650 GO:0006654 GO:0006793 GO:0006796 GO:0008150 GO:0008152 GO:0008374 GO:0008610 GO:0008654 GO:0009058 GO:0009987 GO:0012505 GO:0016020 GO:0016024 GO:0016411 GO:0016740 GO:0016746 GO:0016747 GO:0019637 GO:0019867 GO:0030154 GO:0031090 GO:0031966 GO:0031967 GO:0031968 GO:0031975 GO:0032502 GO:0036149 GO:0042171 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0045017 GO:0046341 GO:0046473 GO:0046474 GO:0046486 GO:0046488 GO:0048869 GO:0071617 GO:0071704 GO:0090407 GO:0098588 GO:0110165 GO:1901576
4938	2'-5'-oligoadenylate synthetase 1	OAS1	Homo sapiens (human)	9606	primary immunodeficiency disease	DOID:612	2'-5'-oligoadenylate synthetase activity ATP binding RNA binding activation of immune response activation of innate immune response adenyl nucleotide binding adenyl ribonucleotide binding adenylyltransferase activity anion binding antiviral innate immune response binding biological process involved in interspecies interaction between organisms biological regulation biological_process carbohydrate derivative binding carbohydrate homeostasis carbohydrate metabolic process catalytic activity cation binding cell surface pattern recognition receptor signaling pathway cell surface receptor signaling pathway cell surface toll-like receptor signaling pathway cellular anatomical entity cellular component assembly cellular component organization or biogenesis cellular component organization cellular process cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to interferon-alpha cellular response to interferon-beta cellular response to organic substance cellular response to stimulus cellular response to virus cellular_component chemical homeostasis cytokine-mediated signaling pathway cytoplasm cytoplasmic pattern recognition receptor signaling pathway cytosol defense response to bacterium defense response to other organism defense response to symbiont defense response to virus defense response double-stranded RNA binding endolysosomal toll-like receptor signaling pathway endoplasmic reticulum extracellular region glucose homeostasis glucose metabolic process heterocyclic compound binding hexose metabolic process homeostatic process immune response-activating cell surface receptor signaling pathway immune response-activating signaling pathway immune response-regulating cell surface receptor signaling pathway immune response-regulating signaling pathway immune response immune system process innate immune response activating cell surface receptor signaling pathway innate immune response-activating signaling pathway innate immune response interferon-mediated signaling pathway interleukin-27-mediated signaling pathway intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle intracellular receptor signaling pathway ion binding membrane-bounded organelle membrane metabolic process metal ion binding mitochondrion molecular_function monosaccharide metabolic process multicellular organismal process multicellular organismal-level chemical homeostasis multicellular organismal-level homeostasis negative regulation of IP-10 production negative regulation of biological process negative regulation of biosynthetic process negative regulation of cell communication negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of chemokine production negative regulation of cytokine production negative regulation of cytokine-mediated signaling pathway negative regulation of defense response negative regulation of gene expression negative regulation of immune response negative regulation of immune system process negative regulation of innate immune response negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process negative regulation of response to biotic stimulus negative regulation of response to cytokine stimulus negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of type I interferon-mediated signaling pathway negative regulation of viral genome replication negative regulation of viral process non-membrane-bounded organelle nucleic acid binding nucleoplasm nucleoside phosphate binding nucleotide binding nucleotidyltransferase activity nucleus organelle organic cyclic compound binding organic substance metabolic process pattern recognition receptor signaling pathway positive regulation of biological process positive regulation of biosynthetic process positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cellular respiration positive regulation of chemokine production positive regulation of cytokine production positive regulation of defense response positive regulation of gene expression positive regulation of immune response positive regulation of immune system process positive regulation of innate immune response positive regulation of interferon-beta production positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of monocyte chemotactic protein-1 production positive regulation of multicellular organismal process positive regulation of response to biotic stimulus positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of type I interferon production primary metabolic process protein binding protein complex oligomerization protein-containing complex assembly protein-containing complex organization purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding regulation of IP-10 production regulation of RNA metabolic process regulation of biological process regulation of biosynthetic process regulation of catalytic activity regulation of cell communication regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cellular respiration regulation of chemokine (C-X-C motif) ligand 2 production regulation of chemokine production regulation of cytokine production regulation of cytokine-mediated signaling pathway regulation of defense response regulation of gene expression regulation of generation of precursor metabolites and energy regulation of hydrolase activity regulation of immune response regulation of immune system process regulation of innate immune response regulation of interferon-beta production regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of monocyte chemotactic protein-1 production regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of nuclease activity regulation of nucleobase-containing compound metabolic process regulation of primary metabolic process regulation of response to biotic stimulus regulation of response to cytokine stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of ribonuclease activity regulation of signal transduction regulation of signaling regulation of tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of type I interferon production regulation of type I interferon-mediated signaling pathway regulation of viral genome replication regulation of viral life cycle regulation of viral process response to bacterium response to biotic stimulus response to chemical response to cytokine response to external biotic stimulus response to external stimulus response to interferon-alpha response to interferon-beta response to organic substance response to other organism response to stimulus response to stress response to virus ribonucleotide binding ribosome signal transduction small molecule binding small molecule metabolic process surfactant homeostasis toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway transferase activity, transferring phosphorus-containing groups transferase activity type I interferon-mediated signaling pathway	GO:0000166 GO:0001730 GO:0001817 GO:0001818 GO:0001819 GO:0001959 GO:0001960 GO:0002218 GO:0002220 GO:0002221 GO:0002253 GO:0002376 GO:0002429 GO:0002682 GO:0002683 GO:0002684 GO:0002752 GO:0002753 GO:0002757 GO:0002758 GO:0002764 GO:0002768 GO:0002831 GO:0002832 GO:0002833 GO:0003674 GO:0003676 GO:0003723 GO:0003725 GO:0003824 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005576 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0005840 GO:0005975 GO:0005996 GO:0006006 GO:0006950 GO:0006952 GO:0006955 GO:0007165 GO:0007166 GO:0008150 GO:0008152 GO:0009605 GO:0009607 GO:0009615 GO:0009617 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009966 GO:0009968 GO:0009987 GO:0010033 GO:0010468 GO:0010556 GO:0010557 GO:0010558 GO:0010604 GO:0010605 GO:0010628 GO:0010629 GO:0010646 GO:0010648 GO:0016020 GO:0016043 GO:0016740 GO:0016772 GO:0016779 GO:0017076 GO:0019219 GO:0019221 GO:0019222 GO:0019318 GO:0022607 GO:0023051 GO:0023057 GO:0030522 GO:0030554 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031347 GO:0031348 GO:0031349 GO:0032069 GO:0032101 GO:0032102 GO:0032103 GO:0032479 GO:0032481 GO:0032501 GO:0032553 GO:0032555 GO:0032559 GO:0032642 GO:0032648 GO:0032680 GO:0032682 GO:0032722 GO:0032728 GO:0032760 GO:0033500 GO:0034097 GO:0034138 GO:0034142 GO:0035455 GO:0035456 GO:0035457 GO:0035458 GO:0035639 GO:0036094 GO:0042221 GO:0042592 GO:0042593 GO:0042742 GO:0043129 GO:0043167 GO:0043168 GO:0043169 GO:0043207 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043457 GO:0043467 GO:0043933 GO:0044238 GO:0044281 GO:0044419 GO:0045069 GO:0045071 GO:0045087 GO:0045088 GO:0045089 GO:0045824 GO:0046872 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048525 GO:0048583 GO:0048584 GO:0048585 GO:0048871 GO:0048878 GO:0050776 GO:0050777 GO:0050778 GO:0050789 GO:0050790 GO:0050792 GO:0050794 GO:0050896 GO:0051171 GO:0051239 GO:0051240 GO:0051241 GO:0051252 GO:0051259 GO:0051336 GO:0051607 GO:0051707 GO:0051716 GO:0060255 GO:0060337 GO:0060338 GO:0060339 GO:0060700 GO:0060759 GO:0060761 GO:0065003 GO:0065007 GO:0065009 GO:0070106 GO:0070566 GO:0070887 GO:0071310 GO:0071345 GO:0071637 GO:0071639 GO:0071658 GO:0071659 GO:0071704 GO:0071840 GO:0080090 GO:0080134 GO:0097159 GO:0097367 GO:0098542 GO:0098586 GO:0110165 GO:0140374 GO:0140546 GO:0140888 GO:0140894 GO:0140895 GO:0140962 GO:1901265 GO:1901363 GO:1901857 GO:1903555 GO:1903557 GO:1903900 GO:2000341 GO:2000342
4940	2'-5'-oligoadenylate synthetase 3	OAS3	Homo sapiens (human)	9606			2'-5'-oligoadenylate synthetase activity ATP binding MDA-5 signaling pathway RIG-I signaling pathway RNA binding activation of immune response activation of innate immune response adenyl nucleotide binding adenyl ribonucleotide binding adenylyltransferase activity anion binding antiviral innate immune response binding biological process involved in interspecies interaction between organisms biological regulation biological_process carbohydrate derivative binding catalytic activity cation binding cell surface receptor signaling pathway cellular anatomical entity cellular aromatic compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular_component cytokine-mediated signaling pathway cytoplasm cytoplasmic pattern recognition receptor signaling pathway cytosol defense response to bacterium defense response to other organism defense response to symbiont defense response to virus defense response double-stranded RNA binding extracellular space heterocycle metabolic process heterocyclic compound binding immune response-activating signaling pathway immune response-regulating signaling pathway immune response immune system process innate immune response-activating signaling pathway innate immune response interferon-mediated signaling pathway interleukin-27-mediated signaling pathway intracellular membrane-bounded organelle intracellular organelle intracellular receptor signaling pathway ion binding membrane-bounded organelle membrane metabolic process metal ion binding molecular_function negative regulation of IP-10 production negative regulation of biological process negative regulation of biosynthetic process negative regulation of cell communication negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of chemokine (C-C motif) ligand 5 production negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of chemokine (C-X-C motif) ligand 9 production negative regulation of chemokine production negative regulation of cytokine production negative regulation of cytokine-mediated signaling pathway negative regulation of defense response negative regulation of gene expression negative regulation of immune response negative regulation of immune system process negative regulation of innate immune response negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process negative regulation of response to biotic stimulus negative regulation of response to cytokine stimulus negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of type I interferon-mediated signaling pathway negative regulation of viral genome replication negative regulation of viral process nitrogen compound metabolic process nucleic acid binding nucleobase-containing compound metabolic process nucleoplasm nucleoside phosphate binding nucleotide binding nucleotidyltransferase activity organelle organic cyclic compound binding organic cyclic compound metabolic process organic substance metabolic process pattern recognition receptor signaling pathway plasma membrane positive regulation of biological process positive regulation of biosynthetic process positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of chemokine production positive regulation of cytokine production positive regulation of defense response positive regulation of gene expression positive regulation of immune response positive regulation of immune system process positive regulation of innate immune response positive regulation of interferon-beta production positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of monocyte chemotactic protein-1 production positive regulation of multicellular organismal process positive regulation of response to biotic stimulus positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of type I interferon production primary metabolic process protein binding purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding regulation of IP-10 production regulation of RNA metabolic process regulation of biological process regulation of biosynthetic process regulation of catalytic activity regulation of cell communication regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of chemokine (C-C motif) ligand 5 production regulation of chemokine (C-X-C motif) ligand 2 production regulation of chemokine (C-X-C motif) ligand 9 production regulation of chemokine production regulation of cytokine production regulation of cytokine-mediated signaling pathway regulation of defense response regulation of gene expression regulation of hydrolase activity regulation of immune response regulation of immune system process regulation of innate immune response regulation of interferon-beta production regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of monocyte chemotactic protein-1 production regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of nuclease activity regulation of nucleobase-containing compound metabolic process regulation of primary metabolic process regulation of response to biotic stimulus regulation of response to cytokine stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of ribonuclease activity regulation of signal transduction regulation of signaling regulation of tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of type I interferon production regulation of type I interferon-mediated signaling pathway regulation of viral genome replication regulation of viral life cycle regulation of viral process response to bacterium response to biotic stimulus response to external biotic stimulus response to external stimulus response to other organism response to stimulus response to stress response to virus ribonucleotide binding signal transduction small molecule binding transferase activity, transferring phosphorus-containing groups transferase activity type I interferon-mediated signaling pathway	GO:0000166 GO:0001730 GO:0001817 GO:0001818 GO:0001819 GO:0001959 GO:0001960 GO:0002218 GO:0002221 GO:0002253 GO:0002376 GO:0002682 GO:0002683 GO:0002684 GO:0002753 GO:0002757 GO:0002758 GO:0002764 GO:0002831 GO:0002832 GO:0002833 GO:0003674 GO:0003676 GO:0003723 GO:0003725 GO:0003824 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005615 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006139 GO:0006725 GO:0006807 GO:0006950 GO:0006952 GO:0006955 GO:0007165 GO:0007166 GO:0008150 GO:0008152 GO:0009605 GO:0009607 GO:0009615 GO:0009617 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009966 GO:0009968 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010558 GO:0010604 GO:0010605 GO:0010628 GO:0010629 GO:0010646 GO:0010648 GO:0016020 GO:0016740 GO:0016772 GO:0016779 GO:0017076 GO:0019219 GO:0019221 GO:0019222 GO:0023051 GO:0023057 GO:0030522 GO:0030554 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031347 GO:0031348 GO:0031349 GO:0032069 GO:0032101 GO:0032102 GO:0032103 GO:0032479 GO:0032481 GO:0032553 GO:0032555 GO:0032559 GO:0032642 GO:0032648 GO:0032680 GO:0032682 GO:0032722 GO:0032728 GO:0032760 GO:0034641 GO:0035394 GO:0035395 GO:0035639 GO:0036094 GO:0039529 GO:0039530 GO:0042742 GO:0043167 GO:0043168 GO:0043169 GO:0043207 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0044237 GO:0044238 GO:0044419 GO:0045069 GO:0045071 GO:0045087 GO:0045088 GO:0045089 GO:0045824 GO:0046483 GO:0046872 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048525 GO:0048583 GO:0048584 GO:0048585 GO:0050776 GO:0050777 GO:0050778 GO:0050789 GO:0050790 GO:0050792 GO:0050794 GO:0050896 GO:0051171 GO:0051239 GO:0051240 GO:0051241 GO:0051252 GO:0051336 GO:0051607 GO:0051707 GO:0060255 GO:0060337 GO:0060338 GO:0060339 GO:0060700 GO:0060759 GO:0060761 GO:0065007 GO:0065009 GO:0070106 GO:0070566 GO:0071637 GO:0071639 GO:0071649 GO:0071650 GO:0071658 GO:0071659 GO:0071704 GO:0080090 GO:0080134 GO:0097159 GO:0097367 GO:0098542 GO:0110165 GO:0140374 GO:0140546 GO:0140888 GO:1901265 GO:1901360 GO:1901363 GO:1903555 GO:1903557 GO:1903900 GO:2000341 GO:2000342
10591	2'-deoxynucleoside 5'-phosphate N-hydrolase 1	DNPH1 Aliases: dJ330M21.3 rcl	Homo sapiens (human)	9606			aromatic compound biosynthetic process aromatic compound catabolic process binding biological regulation biological_process biosynthetic process carbohydrate derivative biosynthetic process carbohydrate derivative metabolic process catabolic process catalytic activity cell differentiation cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular catabolic process cellular developmental process cellular metabolic compound salvage cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound catabolic process cellular nitrogen compound metabolic process cellular process cellular_component cytoplasm cytosol deoxyribonucleoside 5'-monophosphate N-glycosidase activity deoxyribonucleoside monophosphate catabolic process deoxyribonucleoside monophosphate metabolic process developmental process epithelial cell differentiation extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle glycosyl compound biosynthetic process glycosyl compound metabolic process heterocycle biosynthetic process heterocycle catabolic process heterocycle metabolic process hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds hydrolase activity identical protein binding intracellular membrane-bounded organelle intracellular organelle membrane-bounded organelle metabolic process molecular_function nitrogen compound metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule biosynthetic process nucleobase-containing small molecule metabolic process nucleoside biosynthetic process nucleoside metabolic process nucleoside monophosphate catabolic process nucleoside monophosphate metabolic process nucleoside phosphate catabolic process nucleoside phosphate metabolic process nucleoside salvage nucleotide catabolic process nucleotide metabolic process nucleus organelle organic cyclic compound biosynthetic process organic cyclic compound catabolic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance catabolic process organic substance metabolic process organonitrogen compound biosynthetic process organonitrogen compound catabolic process organonitrogen compound metabolic process organophosphate catabolic process organophosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of biological process positive regulation of cell growth positive regulation of cellular process positive regulation of growth primary metabolic process protein binding protein dimerization activity protein homodimerization activity purine nucleotide catabolic process purine nucleotide metabolic process purine-containing compound catabolic process purine-containing compound metabolic process regulation of biological process regulation of cell growth regulation of cellular component organization regulation of cellular process regulation of growth small molecule biosynthetic process small molecule metabolic process vesicle	GO:0001558 GO:0003674 GO:0003824 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005737 GO:0005829 GO:0006139 GO:0006163 GO:0006195 GO:0006725 GO:0006753 GO:0006793 GO:0006796 GO:0006807 GO:0008150 GO:0008152 GO:0009056 GO:0009058 GO:0009116 GO:0009117 GO:0009123 GO:0009125 GO:0009159 GO:0009162 GO:0009163 GO:0009166 GO:0009987 GO:0016787 GO:0016798 GO:0016799 GO:0018130 GO:0019438 GO:0019439 GO:0019637 GO:0030154 GO:0030307 GO:0030855 GO:0031982 GO:0032502 GO:0034404 GO:0034641 GO:0034654 GO:0034655 GO:0040008 GO:0042802 GO:0042803 GO:0043094 GO:0043174 GO:0043226 GO:0043227 GO:0043229 GO:0043230 GO:0043231 GO:0044237 GO:0044238 GO:0044248 GO:0044249 GO:0044270 GO:0044271 GO:0044281 GO:0044283 GO:0045927 GO:0046434 GO:0046483 GO:0046700 GO:0046983 GO:0048518 GO:0048522 GO:0048869 GO:0050789 GO:0050794 GO:0051128 GO:0055086 GO:0065007 GO:0065010 GO:0070062 GO:0070694 GO:0071704 GO:0072521 GO:0072523 GO:0110165 GO:1901135 GO:1901137 GO:1901292 GO:1901360 GO:1901361 GO:1901362 GO:1901564 GO:1901565 GO:1901566 GO:1901575 GO:1901576 GO:1901657 GO:1901659 GO:1903561
26063	2,4-dienoyl-CoA reductase 2	DECR2	Homo sapiens (human)	9606			2,4-dienoyl-CoA reductase (NADPH) activity binding biological_process biosynthetic process bounding membrane of organelle carboxylic acid biosynthetic process carboxylic acid catabolic process carboxylic acid metabolic process catabolic process catalytic activity cellular anatomical entity cellular biosynthetic process cellular catabolic process cellular lipid catabolic process cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytosol fatty acid beta-oxidation using acyl-CoA oxidase fatty acid beta-oxidation fatty acid biosynthetic process fatty acid catabolic process fatty acid metabolic process fatty acid oxidation intracellular membrane-bounded organelle intracellular organelle lipid biosynthetic process lipid catabolic process lipid metabolic process lipid modification lipid oxidation membrane-bounded organelle membrane metabolic process microbody membrane microbody molecular_function monocarboxylic acid biosynthetic process monocarboxylic acid catabolic process monocarboxylic acid metabolic process organelle membrane organelle organic acid biosynthetic process organic acid catabolic process organic acid metabolic process organic substance biosynthetic process organic substance catabolic process organic substance metabolic process oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity oxoacid metabolic process peroxisomal membrane peroxisome primary metabolic process protein binding small molecule biosynthetic process small molecule catabolic process small molecule metabolic process trans-2-enoyl-CoA reductase (NADPH) activity unsaturated fatty acid biosynthetic process unsaturated fatty acid metabolic process	GO:0003674 GO:0003824 GO:0005488 GO:0005515 GO:0005575 GO:0005777 GO:0005778 GO:0005829 GO:0006082 GO:0006629 GO:0006631 GO:0006633 GO:0006635 GO:0006636 GO:0008150 GO:0008152 GO:0008610 GO:0008670 GO:0009056 GO:0009058 GO:0009062 GO:0009987 GO:0016020 GO:0016042 GO:0016053 GO:0016054 GO:0016491 GO:0016627 GO:0016628 GO:0019166 GO:0019395 GO:0019752 GO:0030258 GO:0031090 GO:0031903 GO:0032787 GO:0033540 GO:0033559 GO:0034440 GO:0042579 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043436 GO:0044237 GO:0044238 GO:0044242 GO:0044248 GO:0044249 GO:0044255 GO:0044281 GO:0044282 GO:0044283 GO:0046394 GO:0046395 GO:0071704 GO:0072329 GO:0072330 GO:0098588 GO:0110165 GO:1901575 GO:1901576
26061	2-hydroxyacyl-CoA lyase 1	HACL1	Homo sapiens (human)	9606			2-hydroxyacyl-CoA lyase activity 2-hydroxyphytanoyl-CoA lyase activity ATP binding adenyl nucleotide binding adenyl ribonucleotide binding aldehyde-lyase activity anion binding binding biological_process carbohydrate derivative binding carbon-carbon lyase activity carboxylic acid catabolic process carboxylic acid metabolic process catabolic process catalytic activity cation binding cellular anatomical entity cellular catabolic process cellular component organization or biogenesis cellular component organization cellular lipid catabolic process cellular lipid metabolic process cellular localization cellular macromolecule localization cellular metabolic process cellular process cellular_component cytosol establishment of localization establishment of protein localization to organelle establishment of protein localization to peroxisome establishment of protein localization fatty acid alpha-oxidation fatty acid catabolic process fatty acid metabolic process fatty acid oxidation heterocyclic compound binding identical protein binding intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle ion binding lipid catabolic process lipid metabolic process lipid modification lipid oxidation localization long-chain fatty acid metabolic process lyase activity macromolecule localization magnesium ion binding membrane-bounded organelle membrane-enclosed lumen metabolic process metal ion binding methyl-branched fatty acid metabolic process microbody lumen microbody molecular_function monocarboxylic acid catabolic process monocarboxylic acid metabolic process nucleoplasm nucleoside phosphate binding nucleotide binding organelle lumen organelle organization organelle organic acid catabolic process organic acid metabolic process organic cyclic compound binding organic substance catabolic process organic substance metabolic process oxoacid metabolic process peroxisomal matrix peroxisome organization peroxisome phytanic acid metabolic process primary metabolic process protein binding protein localization to organelle protein localization to peroxisome protein localization protein targeting to peroxisome protein targeting purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding quaternary ammonium group binding ribonucleotide binding small molecule binding small molecule catabolic process small molecule metabolic process sulfur compound binding thiamine pyrophosphate binding vitamin binding	GO:0000166 GO:0000287 GO:0001561 GO:0001676 GO:0003674 GO:0003824 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005654 GO:0005777 GO:0005782 GO:0005829 GO:0006082 GO:0006605 GO:0006625 GO:0006629 GO:0006631 GO:0006996 GO:0007031 GO:0008104 GO:0008150 GO:0008152 GO:0009056 GO:0009062 GO:0009987 GO:0016042 GO:0016043 GO:0016054 GO:0016829 GO:0016830 GO:0016832 GO:0017076 GO:0019395 GO:0019752 GO:0019842 GO:0030258 GO:0030554 GO:0030976 GO:0031907 GO:0031974 GO:0032553 GO:0032555 GO:0032559 GO:0032787 GO:0033036 GO:0033365 GO:0034440 GO:0035639 GO:0036094 GO:0042579 GO:0042802 GO:0043167 GO:0043168 GO:0043169 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0043436 GO:0044237 GO:0044238 GO:0044242 GO:0044248 GO:0044255 GO:0044281 GO:0044282 GO:0045184 GO:0046395 GO:0046872 GO:0050997 GO:0051179 GO:0051234 GO:0051641 GO:0070013 GO:0070727 GO:0071704 GO:0071840 GO:0072329 GO:0072594 GO:0072662 GO:0072663 GO:0097089 GO:0097159 GO:0097367 GO:0106359 GO:0106376 GO:0110165 GO:1901265 GO:1901363 GO:1901575 GO:1901681 GO:1903512
79701	2-oxoglutarate and iron dependent oxygenase domain containing 3	OGFOD3	Homo sapiens (human)	9606			L-ascorbic acid binding anion binding binding carbohydrate binding carboxylic acid binding catalytic activity cation binding cellular anatomical entity cellular_component dioxygenase activity heterocyclic compound binding ion binding iron ion binding membrane metal ion binding molecular_function monosaccharide binding organic acid binding organic cyclic compound binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity small molecule binding transition metal ion binding vitamin binding	GO:0003674 GO:0003824 GO:0005488 GO:0005506 GO:0005575 GO:0016020 GO:0016491 GO:0016705 GO:0019842 GO:0030246 GO:0031406 GO:0031418 GO:0036094 GO:0043167 GO:0043168 GO:0043169 GO:0043177 GO:0046872 GO:0046914 GO:0048029 GO:0051213 GO:0097159 GO:0110165 GO:1901363
92370	2-phosphoxylose phosphatase 1	PXYLP1 Aliases: FLJ23751	Homo sapiens (human)	9606	myopia	DOID:11830	Golgi apparatus Golgi membrane aminoglycan biosynthetic process aminoglycan metabolic process binding biological regulation biological_process biosynthetic process bounding membrane of organelle carbohydrate derivative biosynthetic process carbohydrate derivative metabolic process catalytic activity cellular anatomical entity cellular biosynthetic process cellular metabolic process cellular process cellular_component chondroitin sulfate proteoglycan biosynthetic process chondroitin sulfate proteoglycan metabolic process glycoprotein biosynthetic process glycoprotein metabolic process glycosaminoglycan biosynthetic process glycosaminoglycan metabolic process hydrolase activity, acting on ester bonds hydrolase activity intracellular membrane-bounded organelle intracellular organelle macromolecule biosynthetic process macromolecule metabolic process membrane-bounded organelle membrane metabolic process molecular_function nitrogen compound metabolic process organelle membrane organelle organic substance biosynthetic process organic substance metabolic process organonitrogen compound biosynthetic process organonitrogen compound metabolic process phosphatase activity phosphoric ester hydrolase activity positive regulation of biological process positive regulation of biosynthetic process positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of glycoprotein biosynthetic process positive regulation of glycoprotein metabolic process positive regulation of heparan sulfate proteoglycan biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of nitrogen compound metabolic process positive regulation of protein metabolic process positive regulation of proteoglycan biosynthetic process positive regulation of sulfur metabolic process primary metabolic process protein binding protein metabolic process proteoglycan biosynthetic process proteoglycan metabolic process regulation of biological process regulation of biosynthetic process regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of glycoprotein biosynthetic process regulation of glycoprotein metabolic process regulation of heparan sulfate proteoglycan biosynthetic process regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of nitrogen compound metabolic process regulation of primary metabolic process regulation of protein metabolic process regulation of sulfur metabolic process	GO:0000139 GO:0003674 GO:0003824 GO:0005488 GO:0005515 GO:0005575 GO:0005794 GO:0006022 GO:0006023 GO:0006024 GO:0006029 GO:0006807 GO:0008150 GO:0008152 GO:0009058 GO:0009059 GO:0009100 GO:0009101 GO:0009889 GO:0009891 GO:0009893 GO:0009987 GO:0010556 GO:0010557 GO:0010559 GO:0010560 GO:0010604 GO:0010908 GO:0010909 GO:0016020 GO:0016787 GO:0016788 GO:0016791 GO:0019222 GO:0019538 GO:0030166 GO:0030203 GO:0031090 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0042578 GO:0042762 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0044237 GO:0044238 GO:0044249 GO:0048518 GO:0048522 GO:0050650 GO:0050654 GO:0050789 GO:0050794 GO:0051171 GO:0051173 GO:0051176 GO:0051246 GO:0051247 GO:0060255 GO:0065007 GO:0071704 GO:0080090 GO:0098588 GO:0110165 GO:1901135 GO:1901137 GO:1901564 GO:1901566 GO:1901576 GO:1902730 GO:1903018 GO:1903020
1718	24-dehydrocholesterol reductase	DHCR24 Aliases: Delta(24)-sterol reductase KIAA0018 seladin-1	Homo sapiens (human)	9606	Alzheimer's disease 10 Alzheimer's disease 11 Alzheimer's disease 12 Alzheimer's disease 13 Alzheimer's disease 14 Alzheimer's disease 15 Alzheimer's disease 1 Alzheimer's disease 2 Alzheimer's disease 5 Alzheimer's disease 6 Alzheimer's disease 7 Alzheimer's disease 8 Alzheimer's disease Clouston syndrome Creutzfeldt-Jakob disease Huntington's disease-like 1 Huntington's disease-like 2 Huntington's disease Joubert syndrome Laron syndrome Marfan syndrome Miller-Dieker lissencephaly syndrome Pick's disease Potter's syndrome Q fever Reye syndrome X-linked chondrodysplasia punctata 1 X-linked chondrodysplasia punctata 2 achondroplasia acoustic neuroma actinic keratosis acute myocardial infarction adenocarcinoma adenoma adrenal adenoma adrenal carcinoma adrenal cortex cancer adrenal gland cancer adrenocortical carcinoma adult cystic teratoma adult respiratory distress syndrome adult teratoma angiomatous meningioma arteriolosclerosis arteriosclerosis arteriosclerotic cardiovascular disease arthropathy atherosclerosis autism spectrum disorder autistic disorder autosomal dominant chondrodysplasia punctata autosomal dominant osteopetrosis 2 autosomal recessive osteopetrosis 7 bacterial sepsis benign meningioma bilateral renal aplasia bladder carcinoma brain cancer breast cancer breast carcinoma breast fibroadenoma bronchus cancer bronchus carcinoma cancer carcinoma central nervous system cancer cerebral convexity meningioma cerebral degeneration cerebral infarction cerebrovascular disease cervical adenocarcinoma cervical cancer cervix carcinoma chondrodysplasia punctata chromophobe renal cell carcinoma chronic kidney disease chronic obstructive pulmonary disease clear cell meningioma clear cell renal cell carcinoma cleft palate clubfoot collecting duct carcinoma colon cancer colon carcinoma colonic benign neoplasm colorectal cancer communicating hydrocephalus complex cortical dysplasia with other brain malformations 1 complex cortical dysplasia with other brain malformations 7 congenital nystagmus coronary artery disease coronary thrombosis cortical dysplasia-focal epilepsy syndrome cribriform carcinoma cutaneous mastocytosis cystic teratoma diffuse cutaneous mastocytosis disorder of sexual development dissociated nystagmus embryoma endometrial cancer endometrial carcinoma epilepsy epithelioid leiomyosarcoma epithelioid sarcoma esophageal cancer esophageal carcinoma familial adenomatous polyposis fibrous meningioma follicular adenoma giant cell glioblastoma gingival overgrowth glioblastoma gliosarcoma glucose metabolism disease granular cell carcinoma head and neck squamous cell carcinoma hepatitis C hepatocellular carcinoma hermaphroditism high grade glioma hydranencephaly hydrocephalus hypertropia inflammatory breast carcinoma insulinoma intellectual disability intraorbital meningioma intraventricular meningioma invasive ductal carcinoma islet cell tumor isolated cleft palate kidney cancer large intestine cancer learning disability leiomyoma leiomyosarcoma lipid metabolism disorder lissencephaly liver cancer lung benign neoplasm lung cancer lung carcinoma lung disease lung non-small cell carcinoma lymphoplasmacyte-rich meningioma malignant teratoma mastocytosis mature teratoma mechanical strabismus melanoma meningioma meningothelial meningioma microcephaly microcystic adenoma microcystic meningioma migraine without aura mixed glioma multiple myeloma multiple sclerosis myocardial infarction myofibroma myxoid leiomyosarcoma nasopharynx carcinoma neuroblastoma neurodegenerative disease neurogenic arthropathy obstructive hydrocephalus olfactory groove meningioma ophthalmoplegia osteomyelitis osteopetrosis osteosclerosis ovarian cancer ovarian carcinoma pancreatic cancer pancreatic carcinoma papillary adenocarcinoma papillary adenoma papillary renal cell carcinoma parasagittal meningioma patent ductus arteriosus pathologic nystagmus pituitary adenoma placental insufficiency pontocerebellar hypoplasia type 2D pontocerebellar hypoplasia type 7 pontocerebellar hypoplasia type 8 pontocerebellar hypoplasia type 9 prostate cancer prostate carcinoma psammomatous meningioma pseudohermaphroditism rectal benign neoplasm rectum adenocarcinoma rectum cancer relapsing-remitting multiple sclerosis renal cell carcinoma rhizomelic chondrodysplasia punctata type 1 rhizomelic chondrodysplasia punctata type 2 rhizomelic chondrodysplasia punctata type 3 sarcoma sarcomatoid carcinoma sarcomatoid renal cell carcinoma scimitar syndrome seborrheic keratosis secretory meningioma senile degeneration of brain septooptic dysplasia serous cystadenocarcinoma short-rib thoracic dysplasia 14 with polydactyly silent myocardial infarction situs inversus skin atrophy skin disease skin melanoma spinal meningioma spindle cell sarcoma spontaneous ocular nystagmus status epilepticus strabismus syndromic X-linked intellectual disability Najm type synovitis tenosynovitis teratoma thyroid gland papillary carcinoma transient cerebral ischemia transitional cell carcinoma transitional meningioma trigeminal neuralgia trypanosomiasis tuberous sclerosis tubular adenocarcinoma typhus ureteric orifice cancer urinary bladder cancer urticaria pigmentosa uterine corpus cancer uterine fibroid vertebrobasilar insufficiency visual epilepsy	DOID:0040085 DOID:0050424 DOID:0050453 DOID:0050777 DOID:0060041 DOID:0060270 DOID:0060276 DOID:0060277 DOID:0060278 DOID:0060292 DOID:0060293 DOID:0060469 DOID:0060807 DOID:0060857 DOID:0080200 DOID:0080348 DOID:0080352 DOID:0090103 DOID:0090104 DOID:0090130 DOID:0090132 DOID:0090137 DOID:0110035 DOID:0110037 DOID:0110038 DOID:0110039 DOID:0110041 DOID:0110043 DOID:0110044 DOID:0110045 DOID:0110046 DOID:0110047 DOID:0110048 DOID:0110096 DOID:0110213 DOID:0110851 DOID:0110852 DOID:0110853 DOID:0110938 DOID:0110946 DOID:10113 DOID:1019 DOID:10283 DOID:10286 DOID:1059 DOID:10652 DOID:10907 DOID:10908 DOID:11054 DOID:1107 DOID:11100 DOID:1115 DOID:11256 DOID:1138 DOID:11394 DOID:11771 DOID:11818 DOID:11832 DOID:11836 DOID:11847 DOID:11870 DOID:11949 DOID:12098 DOID:12309 DOID:12594 DOID:12689 DOID:127 DOID:12783 DOID:12849 DOID:12858 DOID:1289 DOID:13003 DOID:13174 DOID:1319 DOID:13223 DOID:1324 DOID:1325 DOID:13515 DOID:13533 DOID:1380 DOID:13832 DOID:14159 DOID:14286 DOID:14323 DOID:1443 DOID:14524 DOID:14525 DOID:14693 DOID:1520 DOID:1573 DOID:1612 DOID:1618 DOID:162 DOID:1793 DOID:1799 DOID:1824 DOID:1826 DOID:1883 DOID:1909 DOID:1923 DOID:1936 DOID:1967 DOID:1984 DOID:1993 DOID:1996 DOID:219 DOID:224 DOID:2348 DOID:2349 DOID:235 DOID:2377 DOID:2378 DOID:2394 DOID:2581 DOID:263 DOID:2660 DOID:2671 DOID:2703 DOID:2733 DOID:2871 DOID:2893 DOID:299 DOID:3008 DOID:305 DOID:3068 DOID:3070 DOID:3071 DOID:3074 DOID:3083 DOID:3086 DOID:3112 DOID:3114 DOID:3146 DOID:3172 DOID:3307 DOID:3393 DOID:3459 DOID:350 DOID:3526 DOID:3565 DOID:3571 DOID:3620 DOID:3663 DOID:3665 DOID:3683 DOID:37 DOID:3702 DOID:3763 DOID:3765 DOID:3772 DOID:381 DOID:3829 DOID:3891 DOID:3892 DOID:3904 DOID:3905 DOID:3908 DOID:3948 DOID:3950 DOID:3953 DOID:3969 DOID:4001 DOID:4007 DOID:4015 DOID:4141 DOID:4194 DOID:4210 DOID:4235 DOID:4254 DOID:4297 DOID:4362 DOID:4386 DOID:4450 DOID:4464 DOID:4465 DOID:4467 DOID:4471 DOID:4473 DOID:4480 DOID:4587 DOID:4588 DOID:4591 DOID:4594 DOID:4626 DOID:4766 DOID:4903 DOID:4905 DOID:4929 DOID:5041 DOID:5076 DOID:5162 DOID:5264 DOID:5268 DOID:539 DOID:540 DOID:5403 DOID:5520 DOID:5563 DOID:5565 DOID:5566 DOID:5672 DOID:5675 DOID:5844 DOID:5854 DOID:6114 DOID:6193 DOID:6204 DOID:6263 DOID:6498 DOID:6548 DOID:656 DOID:657 DOID:660 DOID:6713 DOID:674 DOID:684 DOID:6869 DOID:7079 DOID:7210 DOID:7211 DOID:7212 DOID:7213 DOID:758 DOID:769 DOID:784 DOID:8057 DOID:850 DOID:8866 DOID:8923 DOID:8927 DOID:9256 DOID:9261 DOID:9306 DOID:9408 DOID:9460 DOID:9521 DOID:9538 DOID:9649 DOID:9650 DOID:970 DOID:9837	FAD binding Golgi membrane Ras protein signal transduction alcohol biosynthetic process alcohol metabolic process amide binding amyloid precursor protein catabolic process amyloid precursor protein metabolic process anatomical structure development animal organ development anion binding antigen binding binding biological regulation biological_process biosynthetic process bounding membrane of organelle catalytic activity cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular localization cellular macromolecule localization cellular process cellular_component cholesterol biosynthetic process via desmosterol cholesterol biosynthetic process via lathosterol cholesterol biosynthetic process cholesterol metabolic process cytoplasm delta24(24-1) sterol reductase activity delta24-sterol reductase activity developmental process involved in reproduction developmental process endoplasmic reticulum membrane endoplasmic reticulum enzyme binding flavin adenine dinucleotide binding genitalia development heterocyclic compound binding intracellular membrane-bounded organelle intracellular organelle intracellular signal transduction ion binding lipid biosynthetic process lipid metabolic process localization macromolecule localization macromolecule metabolic process male genitalia development membrane organization membrane-bounded organelle membrane metabolic process molecular_function negative regulation of biological process negative regulation of cell population proliferation negative regulation of cellular process nitrogen compound metabolic process nucleoside phosphate binding nucleotide binding nucleus organelle membrane organelle organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic hydroxy compound biosynthetic process organic hydroxy compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound metabolic process oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity peptide antigen binding peptide binding plasminogen activation primary metabolic process protein binding protein localization protein maturation protein metabolic process protein processing proteolysis regulation of biological process regulation of cell population proliferation regulation of cellular process reproductive process reproductive structure development reproductive system development response to chemical response to endogenous stimulus response to hormone response to organic substance response to stimulus secondary alcohol biosynthetic process secondary alcohol metabolic process signal transduction skin development small GTPase mediated signal transduction small molecule binding small molecule biosynthetic process small molecule metabolic process steroid biosynthetic process steroid metabolic process sterol biosynthetic process sterol metabolic process system development tissue development zymogen activation	GO:0000139 GO:0000166 GO:0000246 GO:0003006 GO:0003674 GO:0003823 GO:0003824 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005737 GO:0005783 GO:0005789 GO:0006066 GO:0006508 GO:0006629 GO:0006694 GO:0006695 GO:0006807 GO:0007165 GO:0007264 GO:0007265 GO:0008104 GO:0008150 GO:0008152 GO:0008202 GO:0008203 GO:0008285 GO:0008610 GO:0009058 GO:0009719 GO:0009725 GO:0009888 GO:0009987 GO:0010033 GO:0016020 GO:0016043 GO:0016125 GO:0016126 GO:0016485 GO:0016491 GO:0016627 GO:0016628 GO:0019538 GO:0019899 GO:0022414 GO:0030539 GO:0031090 GO:0031638 GO:0031639 GO:0032502 GO:0033036 GO:0033218 GO:0033489 GO:0033490 GO:0035556 GO:0036094 GO:0042127 GO:0042221 GO:0042277 GO:0042605 GO:0042982 GO:0042987 GO:0043167 GO:0043168 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043588 GO:0044238 GO:0044281 GO:0044283 GO:0046165 GO:0048513 GO:0048519 GO:0048523 GO:0048608 GO:0048731 GO:0048806 GO:0048856 GO:0050614 GO:0050660 GO:0050789 GO:0050794 GO:0050896 GO:0051179 GO:0051604 GO:0051641 GO:0061024 GO:0061458 GO:0065007 GO:0070727 GO:0071704 GO:0071840 GO:0071949 GO:0097159 GO:0098588 GO:0110165 GO:1901265 GO:1901360 GO:1901362 GO:1901363 GO:1901564 GO:1901576 GO:1901615 GO:1901617 GO:1902652 GO:1902653
10380	3'(2'), 5'-bisphosphate nucleotidase 1	BPNT1	Homo sapiens (human)	9606			3'(2'),5'-bisphosphate nucleotidase activity 3'-phosphoadenosine 5'-phosphosulfate metabolic process anatomical structure development binding biological_process biosynthetic process carbohydrate derivative metabolic process catalytic activity cation binding cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular lipid metabolic process cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular_component cytosol developmental process glycerolipid biosynthetic process glycerolipid metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process heterocycle metabolic process hydrolase activity, acting on ester bonds hydrolase activity inositol bisphosphate phosphatase activity inositol phosphate phosphatase activity inositol-1,4-bisphosphate 1-phosphatase activity intracellular membrane-bounded organelle intracellular organelle ion binding lipid biosynthetic process lipid metabolic process membrane-bounded organelle metabolic process metal ion binding mitochondrion molecular_function nervous system development nitrogen compound metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleoside bisphosphate metabolic process nucleoside phosphate metabolic process nucleotidase activity nucleotide metabolic process organelle organic acid metabolic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound metabolic process organophosphate biosynthetic process organophosphate metabolic process oxoacid metabolic process phosphatase activity phosphate-containing compound metabolic process phosphatidylinositol biosynthetic process phosphatidylinositol metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phospholipid metabolic process phosphoric ester hydrolase activity phosphorus metabolic process primary metabolic process purine nucleoside bisphosphate metabolic process purine nucleotide metabolic process purine ribonucleoside bisphosphate metabolic process purine ribonucleotide metabolic process purine-containing compound metabolic process ribonucleoside bisphosphate metabolic process ribonucleotide metabolic process ribose phosphate metabolic process small molecule metabolic process sulfur compound metabolic process system development	GO:0003674 GO:0003824 GO:0004441 GO:0005488 GO:0005575 GO:0005739 GO:0005829 GO:0006082 GO:0006139 GO:0006163 GO:0006629 GO:0006644 GO:0006650 GO:0006661 GO:0006725 GO:0006753 GO:0006790 GO:0006793 GO:0006796 GO:0006807 GO:0007399 GO:0008150 GO:0008152 GO:0008252 GO:0008441 GO:0008610 GO:0008654 GO:0009058 GO:0009117 GO:0009150 GO:0009259 GO:0009987 GO:0016312 GO:0016787 GO:0016788 GO:0016791 GO:0019637 GO:0019693 GO:0032502 GO:0033865 GO:0033875 GO:0034032 GO:0034035 GO:0034641 GO:0042578 GO:0043167 GO:0043169 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043436 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0044281 GO:0045017 GO:0046474 GO:0046483 GO:0046486 GO:0046488 GO:0046854 GO:0046872 GO:0048731 GO:0048856 GO:0050427 GO:0052745 GO:0055086 GO:0071704 GO:0072521 GO:0090407 GO:0110165 GO:1901135 GO:1901360 GO:1901564 GO:1901576
54928	3'(2'), 5'-bisphosphate nucleotidase 2	BPNT2 Aliases: FLJ20421 Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase IMPA3 gPAPP golgi-resident nucleotide phosphatase	Homo sapiens (human)	9606			3'(2'),5'-bisphosphate nucleotidase activity 3',5'-nucleotide bisphosphate phosphatase activity 3'-nucleotidase activity Golgi apparatus Golgi lumen aminoglycan metabolic process anatomical structure development anatomical structure morphogenesis binding biological_process biosynthetic process carbohydrate derivative metabolic process catalytic activity cation binding cell development cellular anatomical entity cellular biosynthetic process cellular developmental process cellular lipid metabolic process cellular metabolic process cellular process cellular_component chondrocyte development chondroitin sulfate metabolic process cytosol developmental process embryonic digit morphogenesis embryonic morphogenesis endochondral ossification endomembrane system glycerolipid biosynthetic process glycerolipid metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process glycosaminoglycan metabolic process hydrolase activity, acting on ester bonds hydrolase activity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle ion binding lipid biosynthetic process lipid metabolic process macromolecule metabolic process membrane-bounded organelle membrane-enclosed lumen membrane metabolic process metal ion binding molecular_function mucopolysaccharide metabolic process multicellular organismal process nitrogen compound metabolic process nuclear body nucleoplasm nucleotidase activity organelle lumen organelle membrane organelle organic substance biosynthetic process organic substance metabolic process organonitrogen compound metabolic process organophosphate biosynthetic process organophosphate metabolic process ossification phosphatase activity phosphate-containing compound metabolic process phosphatidylinositol biosynthetic process phosphatidylinositol metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phospholipid metabolic process phosphoric ester hydrolase activity phosphorus metabolic process post-embryonic development primary metabolic process replacement ossification skeletal system development sulfur compound metabolic process system development trans-Golgi network membrane	GO:0001501 GO:0001503 GO:0001958 GO:0002063 GO:0003674 GO:0003824 GO:0005488 GO:0005575 GO:0005654 GO:0005794 GO:0005796 GO:0005829 GO:0006022 GO:0006629 GO:0006644 GO:0006650 GO:0006661 GO:0006790 GO:0006793 GO:0006796 GO:0006807 GO:0008150 GO:0008152 GO:0008252 GO:0008254 GO:0008441 GO:0008610 GO:0008654 GO:0009058 GO:0009653 GO:0009791 GO:0009987 GO:0012505 GO:0016020 GO:0016604 GO:0016787 GO:0016788 GO:0016791 GO:0019637 GO:0030203 GO:0030204 GO:0031090 GO:0031974 GO:0032501 GO:0032502 GO:0032588 GO:0036075 GO:0042578 GO:0042733 GO:0043167 GO:0043169 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0045017 GO:0046474 GO:0046486 GO:0046488 GO:0046854 GO:0046872 GO:0048468 GO:0048598 GO:0048731 GO:0048856 GO:0048869 GO:0070013 GO:0071704 GO:0090407 GO:0097657 GO:0110165 GO:1901135 GO:1901564 GO:1901576 GO:1903510
9061	3'-phosphoadenosine 5'-phosphosulfate synthase 1	PAPSS1 Aliases: ATPSK1 PAPSS adenylyl-sulfate kinase sulfate adenylyltransferase	Homo sapiens (human)	9606	cancer embryoma hepatitis B hepatocellular carcinoma liver cancer lung cancer lung non-small cell carcinoma	DOID:1324 DOID:162 DOID:2043 DOID:3571 DOID:3908 DOID:4766 DOID:684	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process ATP binding adenyl nucleotide binding adenyl ribonucleotide binding adenylylsulfate kinase activity adenylyltransferase activity anatomical structure development anion binding aromatic compound biosynthetic process binding biological_process biosynthetic process carbohydrate derivative binding carbohydrate derivative biosynthetic process carbohydrate derivative metabolic process catalytic activity cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular_component cytosol developmental process heterocycle biosynthetic process heterocycle metabolic process heterocyclic compound binding identical protein binding ion binding kinase activity metabolic process molecular_function nitrogen compound metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleoside bisphosphate biosynthetic process nucleoside bisphosphate metabolic process nucleoside phosphate binding nucleoside phosphate biosynthetic process nucleoside phosphate metabolic process nucleotide binding nucleotide biosynthetic process nucleotide metabolic process nucleotidyltransferase activity organic acid metabolic process organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound biosynthetic process organonitrogen compound metabolic process organophosphate biosynthetic process organophosphate metabolic process oxoacid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process phosphorylation phosphotransferase activity, alcohol group as acceptor primary metabolic process protein binding protein dimerization activity protein homodimerization activity purine nucleoside bisphosphate biosynthetic process purine nucleoside bisphosphate metabolic process purine nucleotide binding purine nucleotide biosynthetic process purine nucleotide metabolic process purine ribonucleoside bisphosphate biosynthetic process purine ribonucleoside bisphosphate metabolic process purine ribonucleoside triphosphate binding purine ribonucleotide binding purine ribonucleotide biosynthetic process purine ribonucleotide metabolic process purine-containing compound biosynthetic process purine-containing compound metabolic process ribonucleoside bisphosphate biosynthetic process ribonucleoside bisphosphate metabolic process ribonucleotide binding ribonucleotide biosynthetic process ribonucleotide metabolic process ribose phosphate biosynthetic process ribose phosphate metabolic process skeletal system development small molecule binding small molecule metabolic process sulfate adenylyltransferase (ATP) activity sulfate adenylyltransferase activity sulfate assimilation sulfur compound biosynthetic process sulfur compound metabolic process system development transferase activity, transferring phosphorus-containing groups transferase activity	GO:0000103 GO:0000166 GO:0001501 GO:0003674 GO:0003824 GO:0004020 GO:0004779 GO:0004781 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005829 GO:0006082 GO:0006139 GO:0006163 GO:0006164 GO:0006725 GO:0006753 GO:0006790 GO:0006793 GO:0006796 GO:0006807 GO:0008150 GO:0008152 GO:0009058 GO:0009117 GO:0009150 GO:0009152 GO:0009165 GO:0009259 GO:0009260 GO:0009987 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0016773 GO:0016779 GO:0017076 GO:0018130 GO:0019438 GO:0019637 GO:0019693 GO:0030554 GO:0032502 GO:0032553 GO:0032555 GO:0032559 GO:0033865 GO:0033866 GO:0033875 GO:0034030 GO:0034032 GO:0034033 GO:0034035 GO:0034036 GO:0034641 GO:0034654 GO:0035639 GO:0036094 GO:0042802 GO:0042803 GO:0043167 GO:0043168 GO:0043436 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0044272 GO:0044281 GO:0046390 GO:0046483 GO:0046983 GO:0048731 GO:0048856 GO:0050427 GO:0050428 GO:0055086 GO:0070566 GO:0071704 GO:0072521 GO:0072522 GO:0090407 GO:0097159 GO:0097367 GO:0110165 GO:1901135 GO:1901137 GO:1901265 GO:1901293 GO:1901360 GO:1901362 GO:1901363 GO:1901564 GO:1901566 GO:1901576
9060	3'-phosphoadenosine 5'-phosphosulfate synthase 2	PAPSS2 Aliases: ATPSK2 PAPS synthase 2 adenosine 5'-phosphosulfate kinase bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens (human)	9606	Ehlers-Danlos syndrome Laron syndrome Marfan syndrome achondroplasia acne anovulation arthritis arthropathy brachyolmia diabetes mellitus diastrophic dysplasia hyperandrogenism hypertrichosis intellectual disability learning disability mucopolysaccharidosis IV multiple epiphyseal dysplasia osteoarthritis osteochondrodysplasia osteogenesis imperfecta polycystic ovary syndrome scoliosis situs inversus spondyloepimetaphyseal dysplasia, Pakistani type tuberous sclerosis type 2 diabetes mellitus	DOID:0050690 DOID:0050812 DOID:0060249 DOID:1059 DOID:11612 DOID:11613 DOID:12347 DOID:12721 DOID:12804 DOID:13359 DOID:13515 DOID:14323 DOID:14687 DOID:2256 DOID:3781 DOID:381 DOID:420 DOID:4480 DOID:6543 DOID:758 DOID:8398 DOID:848 DOID:8927 DOID:9351 DOID:9352 DOID:9521	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process ATP binding adenyl nucleotide binding adenyl ribonucleotide binding adenylylsulfate kinase activity adenylyltransferase activity anatomical structure development animal organ development anion binding aromatic compound biosynthetic process binding biological regulation biological_process biosynthetic process blood coagulation bone development carbohydrate derivative binding carbohydrate derivative biosynthetic process carbohydrate derivative metabolic process catalytic activity cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular_component coagulation cytosol developmental process hemostasis heterocycle biosynthetic process heterocycle metabolic process heterocyclic compound binding hormone metabolic process ion binding kinase activity metabolic process molecular_function multicellular organismal process nitrogen compound metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleoside bisphosphate biosynthetic process nucleoside bisphosphate metabolic process nucleoside phosphate binding nucleoside phosphate biosynthetic process nucleoside phosphate metabolic process nucleotide binding nucleotide biosynthetic process nucleotide metabolic process nucleotidyltransferase activity organic acid metabolic process organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound biosynthetic process organonitrogen compound metabolic process organophosphate biosynthetic process organophosphate metabolic process oxoacid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process phosphorylation phosphotransferase activity, alcohol group as acceptor primary metabolic process protein binding purine nucleoside bisphosphate biosynthetic process purine nucleoside bisphosphate metabolic process purine nucleotide binding purine nucleotide biosynthetic process purine nucleotide metabolic process purine ribonucleoside bisphosphate biosynthetic process purine ribonucleoside bisphosphate metabolic process purine ribonucleoside triphosphate binding purine ribonucleotide binding purine ribonucleotide biosynthetic process purine ribonucleotide metabolic process purine-containing compound biosynthetic process purine-containing compound metabolic process regulation of biological quality regulation of body fluid levels regulation of hormone levels ribonucleoside bisphosphate biosynthetic process ribonucleoside bisphosphate metabolic process ribonucleotide binding ribonucleotide biosynthetic process ribonucleotide metabolic process ribose phosphate biosynthetic process ribose phosphate metabolic process small molecule binding small molecule metabolic process sulfate adenylyltransferase (ATP) activity sulfate adenylyltransferase activity sulfate assimilation sulfur compound biosynthetic process sulfur compound metabolic process transferase activity, transferring phosphorus-containing groups transferase activity	GO:0000103 GO:0000166 GO:0003674 GO:0003824 GO:0004020 GO:0004779 GO:0004781 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005829 GO:0006082 GO:0006139 GO:0006163 GO:0006164 GO:0006725 GO:0006753 GO:0006790 GO:0006793 GO:0006796 GO:0006807 GO:0007596 GO:0007599 GO:0008150 GO:0008152 GO:0009058 GO:0009117 GO:0009150 GO:0009152 GO:0009165 GO:0009259 GO:0009260 GO:0009987 GO:0010817 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0016773 GO:0016779 GO:0017076 GO:0018130 GO:0019438 GO:0019637 GO:0019693 GO:0030554 GO:0032501 GO:0032502 GO:0032553 GO:0032555 GO:0032559 GO:0033865 GO:0033866 GO:0033875 GO:0034030 GO:0034032 GO:0034033 GO:0034035 GO:0034036 GO:0034641 GO:0034654 GO:0035639 GO:0036094 GO:0042445 GO:0043167 GO:0043168 GO:0043436 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0044272 GO:0044281 GO:0046390 GO:0046483 GO:0048513 GO:0048856 GO:0050427 GO:0050428 GO:0050817 GO:0050878 GO:0055086 GO:0060348 GO:0065007 GO:0065008 GO:0070566 GO:0071704 GO:0072521 GO:0072522 GO:0090407 GO:0097159 GO:0097367 GO:0110165 GO:1901135 GO:1901137 GO:1901265 GO:1901293 GO:1901360 GO:1901362 GO:1901363 GO:1901564 GO:1901566 GO:1901576
3155	3-hydroxy-3-methylglutaryl-CoA lyase	HMGCL Aliases: HL hydroxymethylglutaricaciduria hydroxymethylglutaryl-CoA lyase	Homo sapiens (human)	9606	Unverricht-Lundborg syndrome X-linked dilated cardiomyopathy acute pancreatitis amino acid metabolic disorder anemia blepharospasm brain disease cancer cardiac arrest congestive heart failure diarrhea dilated cardiomyopathy 1AA dilated cardiomyopathy 1B dilated cardiomyopathy 1BB dilated cardiomyopathy 1C dilated cardiomyopathy 1CC dilated cardiomyopathy 1D dilated cardiomyopathy 1DD dilated cardiomyopathy 1E dilated cardiomyopathy 1EE dilated cardiomyopathy 1FF dilated cardiomyopathy 1G dilated cardiomyopathy 1GG dilated cardiomyopathy 1H dilated cardiomyopathy 1HH dilated cardiomyopathy 1I dilated cardiomyopathy 1II dilated cardiomyopathy 1JJ dilated cardiomyopathy 1K dilated cardiomyopathy 1KK dilated cardiomyopathy 1L dilated cardiomyopathy 1M dilated cardiomyopathy 1NN dilated cardiomyopathy 1O dilated cardiomyopathy 1P dilated cardiomyopathy 1Q dilated cardiomyopathy 1R dilated cardiomyopathy 1S dilated cardiomyopathy 1T dilated cardiomyopathy 1U dilated cardiomyopathy 1V dilated cardiomyopathy 1W dilated cardiomyopathy 1X dilated cardiomyopathy 1Y dilated cardiomyopathy 1Z dilated cardiomyopathy 2A dilated cardiomyopathy 2B dilated cardiomyopathy early myoclonic encephalopathy epilepsy focal hand dystonia hyperlysinemia hyperuricemia hypoglycemia hypoglycemic coma intellectual disability lactic acidosis learning disability leukopenia macrocytic anemia melanoma microcephaly mitochondrial metabolism disease mitochondrial myopathy obsolete infantile epileptic encephalopathy pancreatitis skin melanoma syndromic X-linked intellectual disability 94 thrombocytosis urea cycle disorder visual epilepsy	DOID:0050841 DOID:0060319 DOID:0060823 DOID:0110423 DOID:0110424 DOID:0110426 DOID:0110427 DOID:0110428 DOID:0110429 DOID:0110430 DOID:0110431 DOID:0110432 DOID:0110433 DOID:0110434 DOID:0110435 DOID:0110436 DOID:0110437 DOID:0110438 DOID:0110439 DOID:0110441 DOID:0110442 DOID:0110443 DOID:0110444 DOID:0110445 DOID:0110446 DOID:0110447 DOID:0110448 DOID:0110449 DOID:0110450 DOID:0110451 DOID:0110452 DOID:0110453 DOID:0110454 DOID:0110455 DOID:0110456 DOID:0110457 DOID:0110458 DOID:0110459 DOID:0110460 DOID:0110461 DOID:1059 DOID:10907 DOID:11832 DOID:12930 DOID:13250 DOID:1607 DOID:162 DOID:1826 DOID:1909 DOID:1920 DOID:2228 DOID:2355 DOID:2361 DOID:2481 DOID:2913 DOID:308 DOID:3535 DOID:3650 DOID:4989 DOID:529 DOID:6000 DOID:615 DOID:699 DOID:700 DOID:8923 DOID:8927 DOID:9252 DOID:9267 DOID:9274 DOID:936 DOID:9993	alpha-amino acid catabolic process alpha-amino acid metabolic process amino acid catabolic process amino acid metabolic process binding biological_process biosynthetic process branched-chain amino acid catabolic process branched-chain amino acid metabolic process carbon-carbon lyase activity carboxylic acid catabolic process carboxylic acid metabolic process catabolic process catalytic activity cation binding cellular anatomical entity cellular biosynthetic process cellular catabolic process cellular component organization or biogenesis cellular component organization cellular ketone body metabolic process cellular metabolic process cellular process cellular_component cytosol fatty acid derivative biosynthetic process fatty acid derivative metabolic process generation of precursor metabolites and energy hydroxymethylglutaryl-CoA lyase activity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle ion binding ketone body biosynthetic process ketone body metabolic process leucine catabolic process leucine metabolic process lipid biosynthetic process lipid metabolic process lyase activity magnesium ion binding manganese ion binding membrane-bounded organelle membrane-enclosed lumen metabolic process metal ion binding microbody lumen microbody mitochondrial matrix mitochondrion organization mitochondrion molecular_function nitrogen compound metabolic process organelle lumen organelle organization organelle organic acid catabolic process organic acid metabolic process organic substance biosynthetic process organic substance catabolic process organic substance metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process oxo-acid-lyase activity oxoacid metabolic process peroxisomal matrix peroxisome primary metabolic process protein-containing complex small molecule biosynthetic process small molecule catabolic process small molecule metabolic process structural molecule activity transition metal ion binding	GO:0000287 GO:0003674 GO:0003824 GO:0004419 GO:0005198 GO:0005488 GO:0005575 GO:0005739 GO:0005759 GO:0005777 GO:0005782 GO:0005829 GO:0006082 GO:0006091 GO:0006520 GO:0006551 GO:0006552 GO:0006629 GO:0006807 GO:0006996 GO:0007005 GO:0008150 GO:0008152 GO:0008610 GO:0009056 GO:0009058 GO:0009063 GO:0009081 GO:0009083 GO:0009987 GO:0016043 GO:0016054 GO:0016829 GO:0016830 GO:0016833 GO:0019752 GO:0030145 GO:0031907 GO:0031974 GO:0032991 GO:0042579 GO:0043167 GO:0043169 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0043436 GO:0044237 GO:0044238 GO:0044248 GO:0044249 GO:0044281 GO:0044282 GO:0044283 GO:0046395 GO:0046872 GO:0046914 GO:0046950 GO:0046951 GO:0070013 GO:0071704 GO:0071840 GO:0110165 GO:1901564 GO:1901565 GO:1901568 GO:1901570 GO:1901575 GO:1901576 GO:1901605 GO:1901606 GO:1902224
54511	3-hydroxy-3-methylglutaryl-CoA lyase like 1	HMGCLL1 Aliases: DKFZP434G1411 bA418P12.1	Homo sapiens (human)	9606	chronic myeloid leukemia	DOID:8552	alpha-amino acid catabolic process alpha-amino acid metabolic process amino acid catabolic process amino acid metabolic process binding biological_process biosynthetic process branched-chain amino acid catabolic process branched-chain amino acid metabolic process carbon-carbon lyase activity carboxylic acid catabolic process carboxylic acid metabolic process catabolic process catalytic activity cation binding cellular anatomical entity cellular biosynthetic process cellular catabolic process cellular ketone body metabolic process cellular metabolic process cellular process cellular_component cytosol endoplasmic reticulum membrane endoplasmic reticulum fatty acid derivative biosynthetic process fatty acid derivative metabolic process generation of precursor metabolites and energy hydroxymethylglutaryl-CoA lyase activity intracellular membrane-bounded organelle intracellular organelle ion binding ketone body biosynthetic process ketone body metabolic process leucine catabolic process leucine metabolic process lipid biosynthetic process lipid metabolic process lyase activity membrane-bounded organelle membrane metabolic process metal ion binding molecular_function nitrogen compound metabolic process organelle membrane organelle organic acid catabolic process organic acid metabolic process organic substance biosynthetic process organic substance catabolic process organic substance metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process oxo-acid-lyase activity oxoacid metabolic process perinuclear region of cytoplasm primary metabolic process small molecule biosynthetic process small molecule catabolic process small molecule metabolic process	GO:0003674 GO:0003824 GO:0004419 GO:0005488 GO:0005575 GO:0005783 GO:0005789 GO:0005829 GO:0006082 GO:0006091 GO:0006520 GO:0006551 GO:0006552 GO:0006629 GO:0006807 GO:0008150 GO:0008152 GO:0008610 GO:0009056 GO:0009058 GO:0009063 GO:0009081 GO:0009083 GO:0009987 GO:0016020 GO:0016054 GO:0016829 GO:0016830 GO:0016833 GO:0019752 GO:0031090 GO:0043167 GO:0043169 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043436 GO:0044237 GO:0044238 GO:0044248 GO:0044249 GO:0044281 GO:0044282 GO:0044283 GO:0046395 GO:0046872 GO:0046950 GO:0046951 GO:0048471 GO:0071704 GO:0110165 GO:1901564 GO:1901565 GO:1901568 GO:1901570 GO:1901575 GO:1901576 GO:1901605 GO:1901606 GO:1902224
3156	3-hydroxy-3-methylglutaryl-CoA reductase	HMGCR	Homo sapiens (human)	9606			GTPase regulator activity NADP binding NADPH binding adenyl nucleotide binding adenyl ribonucleotide binding alcohol biosynthetic process alcohol metabolic process anion binding associative learning behavior binding biological regulation biological_process biosynthetic process bounding membrane of organelle carbohydrate derivative binding carbohydrate derivative metabolic process catalytic activity cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular lipid metabolic process cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular_component cholesterol biosynthetic process cholesterol metabolic process coenzyme A binding coenzyme A metabolic process cognition endoplasmic reticulum membrane endoplasmic reticulum enzyme regulator activity heterocycle metabolic process heterocyclic compound binding hydroxymethylglutaryl-CoA reductase (NADPH) activity intracellular membrane-bounded organelle intracellular organelle ion binding isoprenoid biosynthetic process isoprenoid metabolic process learning or memory learning lipid biosynthetic process lipid metabolic process long-term synaptic potentiation membrane-bounded organelle membrane metabolic process microbody membrane microbody modulation of chemical synaptic transmission molecular function regulator activity molecular_function multicellular organismal process negative regulation of amyloid-beta clearance negative regulation of biological process negative regulation of catabolic process negative regulation of cellular process negative regulation of establishment of protein localization negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process negative regulation of nitrogen compound metabolic process negative regulation of protein catabolic process negative regulation of protein localization negative regulation of protein metabolic process negative regulation of protein secretion negative regulation of protein transport negative regulation of secretion by cell negative regulation of secretion negative regulation of transport nervous system process nitrogen compound metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleoside bisphosphate metabolic process nucleoside phosphate binding nucleoside phosphate metabolic process nucleoside-triphosphatase regulator activity nucleotide binding nucleotide metabolic process organelle membrane organelle organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic hydroxy compound biosynthetic process organic hydroxy compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound metabolic process organophosphate metabolic process oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity peroxisomal membrane phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of biological process positive regulation of cell communication positive regulation of cellular process positive regulation of signaling positive regulation of synaptic transmission primary metabolic process protein binding purine nucleoside bisphosphate metabolic process purine nucleotide binding purine nucleotide metabolic process purine ribonucleotide binding purine ribonucleotide metabolic process purine-containing compound metabolic process regulation of ERK1 and ERK2 cascade regulation of MAPK cascade regulation of amyloid-beta clearance regulation of biological process regulation of biological quality regulation of catabolic process regulation of cell communication regulation of cellular localization regulation of cellular process regulation of establishment of protein localization regulation of intracellular signal transduction regulation of localization regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of primary metabolic process regulation of protein catabolic process regulation of protein localization regulation of protein metabolic process regulation of protein secretion regulation of protein transport regulation of response to stimulus regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling regulation of synaptic plasticity regulation of trans-synaptic signaling regulation of transport response to abiotic stimulus response to light stimulus response to radiation response to stimulus ribonucleoside bisphosphate metabolic process ribonucleotide binding ribonucleotide metabolic process ribose phosphate metabolic process secondary alcohol biosynthetic process secondary alcohol metabolic process small molecule binding small molecule biosynthetic process small molecule metabolic process steroid biosynthetic process steroid metabolic process sterol biosynthetic process sterol metabolic process system process visual behavior visual learning	GO:0000166 GO:0003008 GO:0003674 GO:0003824 GO:0004420 GO:0005488 GO:0005515 GO:0005575 GO:0005778 GO:0005783 GO:0005789 GO:0006066 GO:0006139 GO:0006163 GO:0006629 GO:0006694 GO:0006695 GO:0006720 GO:0006725 GO:0006753 GO:0006793 GO:0006796 GO:0006807 GO:0007610 GO:0007611 GO:0007612 GO:0007632 GO:0008150 GO:0008152 GO:0008202 GO:0008203 GO:0008299 GO:0008306 GO:0008542 GO:0008610 GO:0009058 GO:0009117 GO:0009150 GO:0009259 GO:0009314 GO:0009416 GO:0009628 GO:0009892 GO:0009894 GO:0009895 GO:0009966 GO:0009987 GO:0010605 GO:0010646 GO:0010647 GO:0015936 GO:0016020 GO:0016125 GO:0016126 GO:0016491 GO:0016614 GO:0016616 GO:0017076 GO:0019222 GO:0019637 GO:0019693 GO:0023051 GO:0023056 GO:0030234 GO:0030554 GO:0030695 GO:0031090 GO:0031903 GO:0032501 GO:0032553 GO:0032555 GO:0032559 GO:0032879 GO:0032880 GO:0033865 GO:0033875 GO:0034032 GO:0034641 GO:0036094 GO:0042176 GO:0042177 GO:0042579 GO:0043167 GO:0043168 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043408 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0044281 GO:0044283 GO:0046165 GO:0046483 GO:0048167 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0050661 GO:0050708 GO:0050709 GO:0050789 GO:0050794 GO:0050804 GO:0050806 GO:0050877 GO:0050890 GO:0050896 GO:0051046 GO:0051048 GO:0051049 GO:0051051 GO:0051171 GO:0051172 GO:0051223 GO:0051224 GO:0051239 GO:0051241 GO:0051246 GO:0051248 GO:0055086 GO:0060255 GO:0060291 GO:0060341 GO:0060589 GO:0065007 GO:0065008 GO:0070201 GO:0070372 GO:0070402 GO:0071704 GO:0072521 GO:0080090 GO:0097159 GO:0097367 GO:0098588 GO:0098772 GO:0099177 GO:0110165 GO:0120225 GO:1900221 GO:1900222 GO:1901135 GO:1901265 GO:1901360 GO:1901362 GO:1901363 GO:1901564 GO:1901576 GO:1901615 GO:1901617 GO:1902531 GO:1902652 GO:1902653 GO:1903530 GO:1903531 GO:1903828 GO:1904950
3157	3-hydroxy-3-methylglutaryl-CoA synthase 1	HMGCS1 Aliases: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase	Homo sapiens (human)	9606	colon cancer colon carcinoma colonic benign neoplasm colorectal cancer hepatitis C hepatoblastoma hepatocellular carcinoma large intestine cancer obesity prostate cancer prostate carcinoma spinal cord disease	DOID:10283 DOID:10286 DOID:1520 DOID:1883 DOID:219 DOID:235 DOID:319 DOID:5672 DOID:684 DOID:687 DOID:9256 DOID:9970	acetyl-CoA metabolic process acyl-CoA metabolic process acyltransferase activity, acyl groups converted into alkyl on transfer acyltransferase activity alcohol biosynthetic process alcohol metabolic process amide metabolic process binding biological_process biosynthetic process carbohydrate derivative metabolic process catalytic activity cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular lipid metabolic process cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular_component cholesterol biosynthetic process cholesterol metabolic process cytoplasm cytosol farnesyl diphosphate biosynthetic process, mevalonate pathway farnesyl diphosphate biosynthetic process farnesyl diphosphate metabolic process heterocycle metabolic process hydroxymethylglutaryl-CoA synthase activity identical protein binding isoprenoid biosynthetic process via mevalonate isoprenoid biosynthetic process isoprenoid metabolic process lipid biosynthetic process lipid metabolic process metabolic process molecular_function nitrogen compound metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleoside bisphosphate metabolic process nucleoside phosphate metabolic process nucleotide metabolic process organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic hydroxy compound biosynthetic process organic hydroxy compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound metabolic process organophosphate biosynthetic process organophosphate metabolic process phosphate-containing compound metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphorus metabolic process primary metabolic process protein binding protein dimerization activity protein homodimerization activity purine nucleoside bisphosphate metabolic process purine nucleotide metabolic process purine ribonucleotide metabolic process purine-containing compound metabolic process ribonucleoside bisphosphate metabolic process ribonucleotide metabolic process ribose phosphate metabolic process secondary alcohol biosynthetic process secondary alcohol metabolic process small molecule biosynthetic process small molecule metabolic process steroid biosynthetic process steroid metabolic process sterol biosynthetic process sterol metabolic process sulfur compound metabolic process terpenoid biosynthetic process terpenoid metabolic process thioester metabolic process transferase activity	GO:0003674 GO:0003824 GO:0004421 GO:0005488 GO:0005515 GO:0005575 GO:0005737 GO:0005829 GO:0006066 GO:0006084 GO:0006139 GO:0006163 GO:0006629 GO:0006637 GO:0006644 GO:0006694 GO:0006695 GO:0006720 GO:0006721 GO:0006725 GO:0006753 GO:0006790 GO:0006793 GO:0006796 GO:0006807 GO:0008150 GO:0008152 GO:0008202 GO:0008203 GO:0008299 GO:0008610 GO:0008654 GO:0009058 GO:0009117 GO:0009150 GO:0009259 GO:0009987 GO:0010142 GO:0016114 GO:0016125 GO:0016126 GO:0016740 GO:0016746 GO:0019637 GO:0019693 GO:0033865 GO:0033875 GO:0034032 GO:0034641 GO:0035383 GO:0042802 GO:0042803 GO:0043603 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0044281 GO:0044283 GO:0045337 GO:0045338 GO:0046165 GO:0046483 GO:0046912 GO:0046983 GO:0055086 GO:0071704 GO:0072521 GO:0090407 GO:0110165 GO:1901135 GO:1901360 GO:1901362 GO:1901564 GO:1901576 GO:1901615 GO:1901617 GO:1902652 GO:1902653 GO:1902767
3158	3-hydroxy-3-methylglutaryl-CoA synthase 2

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