GlyCosmos Portal

GlyCosmos Genes

Integrated list of glycan-related genes extracted KEGG GENES Database, UniProt, GlycoGene Database (GGDB), Plant GARDEN and FlyGlycoDB. Glycan-related genes including glycosyltransferase, hydrolase activity (acting on glycosyl bonds), carbohydrate metabolic process, etc .

Source	Last Updated
FlyGlycoDB	March 25, 2024
GlycoGene Database (GGDB)	January 26, 2018
KEGG GENES Database	September 20, 2023
Plant GARDEN	May 28, 2020
UniProt	October 29, 2024

Selecting the function you want to look up from the categories displays a list narrowed down to glycan-related genes with that function (Gene Ontology).

Catalytic activity

glycosyltransferase activity

hydrolase activity, acting on glycosyl bonds

Binding

carbohydrate binding

Response to carbohydrate

Primary metabolic process

Displaying entries **1 - 25** of **10109** in total

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Gene ID	Gene Name	Gene Symbol	Organism	Taxonomy ID	Disease Ontology	Disease Ontology ID	Gene Ontology	Gene Ontology ID ▲
4205	myocyte enhancer factor 2A	MEF2A	Homo sapiens (human)	9606	dilated cardiomyopathy	DOID:12930	DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor binding DNA-templated transcription ERK5 cascade MAPK cascade RNA biosynthetic process RNA metabolic process RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding SMAD binding actin cytoskeleton organization actin filament-based process actomyosin structure organization anatomical structure development anatomical structure formation involved in morphogenesis anatomical structure morphogenesis animal organ development apoptotic process aromatic compound biosynthetic process binding biological regulation biological_process biosynthetic process cardiac conduction cardiac myofibril assembly cell death cell differentiation cell projection morphogenesis cell projection organization cellular anatomical entity morphogenesis cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular component assembly involved in morphogenesis cellular component assembly cellular component organization or biogenesis cellular component organization cellular developmental process cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular response to calcium ion cellular response to chemical stimulus cellular response to inorganic substance cellular response to metal ion cellular response to oxygen-containing compound cellular response to salt cellular response to stimulus cellular_component chromatin binding chromatin cis-regulatory region sequence-specific DNA binding cytoskeleton organization cytosol dendrite morphogenesis developmental process double-stranded DNA binding enzyme binding heart development heterocycle biosynthetic process heterocycle metabolic process histone acetyltransferase binding histone deacetylase binding intracellular membrane-bounded organelle intracellular organelle intracellular signal transduction kinase binding localization macromolecule biosynthetic process macromolecule metabolic process membrane-bounded organelle metabolic process mitochondrial genome maintenance mitochondrion distribution mitochondrion localization mitochondrion organization molecular_function muscle organ development muscle structure development myofibril assembly negative regulation of DNA-templated transcription negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of biological process negative regulation of biosynthetic process negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of transcription by RNA polymerase II neuron projection morphogenesis nitrogen compound metabolic process non-membrane-bounded organelle assembly nucleic acid binding nucleic acid metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleoplasm nucleus organelle assembly organelle localization organelle organization organelle organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process plasma membrane bounded cell projection morphogenesis positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of cardiac muscle hypertrophy positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of gene expression positive regulation of glucose import positive regulation of glucose transmembrane transport positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of muscle hypertrophy positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of transmembrane transport positive regulation of transport primary metabolic process programmed cell death protein binding protein dimerization activity protein heterodimerization activity protein kinase binding protein-DNA complex protein-containing complex binding protein-containing complex regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of biological process regulation of biosynthetic process regulation of blood circulation regulation of cardiac muscle hypertrophy regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of gene expression regulation of glucose import regulation of glucose transmembrane transport regulation of heart contraction regulation of localization regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process regulation of muscle adaptation regulation of muscle hypertrophy regulation of muscle system process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of primary metabolic process regulation of response to stimulus regulation of system process regulation of transcription by RNA polymerase II regulation of transmembrane transport regulation of transport response to calcium ion response to chemical response to inorganic substance response to metal ion response to organic substance response to oxygen-containing compound response to salt response to stimulus sequence-specific DNA binding sequence-specific double-stranded DNA binding signal transduction supramolecular fiber organization transcription cis-regulatory region binding transcription factor binding transcription regulator activity transcription regulator complex transcription regulatory region nucleic acid binding ventricular cardiac myofibril assembly	GO:0000002 GO:0000122 GO:0000165 GO:0000785 GO:0000976 GO:0000977 GO:0000978 GO:0000981 GO:0000987 GO:0001067 GO:0001216 GO:0001228 GO:0003674 GO:0003676 GO:0003677 GO:0003682 GO:0003690 GO:0003700 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005667 GO:0005829 GO:0006139 GO:0006351 GO:0006355 GO:0006357 GO:0006725 GO:0006807 GO:0006915 GO:0006996 GO:0007005 GO:0007010 GO:0007165 GO:0007507 GO:0007517 GO:0008016 GO:0008134 GO:0008150 GO:0008152 GO:0008219 GO:0009058 GO:0009059 GO:0009653 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009987 GO:0010033 GO:0010035 GO:0010038 GO:0010468 GO:0010556 GO:0010557 GO:0010558 GO:0010604 GO:0010605 GO:0010611 GO:0010613 GO:0010628 GO:0010827 GO:0010828 GO:0010927 GO:0012501 GO:0014742 GO:0014743 GO:0016043 GO:0016070 GO:0018130 GO:0019219 GO:0019222 GO:0019438 GO:0019899 GO:0019900 GO:0019901 GO:0022607 GO:0030029 GO:0030030 GO:0030036 GO:0030154 GO:0030239 GO:0031032 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0032502 GO:0032774 GO:0032879 GO:0032989 GO:0032991 GO:0032993 GO:0034641 GO:0034654 GO:0034762 GO:0034764 GO:0035035 GO:0035556 GO:0042221 GO:0042826 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043502 GO:0043565 GO:0044057 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0044877 GO:0045892 GO:0045893 GO:0045934 GO:0045935 GO:0045944 GO:0046324 GO:0046326 GO:0046332 GO:0046483 GO:0046982 GO:0046983 GO:0048311 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048646 GO:0048812 GO:0048813 GO:0048856 GO:0048858 GO:0048869 GO:0050789 GO:0050794 GO:0050896 GO:0051049 GO:0051050 GO:0051171 GO:0051172 GO:0051173 GO:0051179 GO:0051239 GO:0051240 GO:0051252 GO:0051253 GO:0051254 GO:0051592 GO:0051640 GO:0051646 GO:0051716 GO:0055003 GO:0055005 GO:0060255 GO:0061061 GO:0061337 GO:0061629 GO:0065007 GO:0070375 GO:0070887 GO:0070925 GO:0071241 GO:0071248 GO:0071277 GO:0071704 GO:0071840 GO:0080090 GO:0090257 GO:0090304 GO:0097159 GO:0097435 GO:0110165 GO:0120039 GO:0140110 GO:0140297 GO:0140694 GO:1901360 GO:1901362 GO:1901576 GO:1901700 GO:1901701 GO:1902074 GO:1902075 GO:1902679 GO:1902680 GO:1903522 GO:1990837 GO:2001141
4976	OPA1 mitochondrial dynamin like GTPase	OPA1 Aliases: Dynamin-like 120 kDa protein, mitochondrial FLJ12460 KIAA0567 MGM1 NPG NTG dynamin-like guanosine triphosphatase mitochondrial dynamin-like GTPase	Homo sapiens (human)	9606	Behr syndrome dominant optic atrophy plus syndrome mitochondrial DNA depletion syndrome 14 optic atrophy 1 optic atrophy	DOID:0080336 DOID:0111340 DOID:0111441 DOID:0111580 DOID:5723	GTP binding GTP metabolic process GTPase activity GTPase-dependent fusogenic activity anatomical structure formation involved in morphogenesis anion binding apoptotic process axo-dendritic transport axon cytoplasm axonal transport of mitochondrion axonal transport binding biological regulation biological_process bounding membrane of organelle carbohydrate derivative binding carbohydrate derivative metabolic process cardiolipin binding catalytic activity cation binding cell death cell projection cellular anatomical entity cellular aromatic compound metabolic process cellular component assembly cellular component organization or biogenesis cellular component organization cellular localization cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular senescence cellular_component cristae formation cytoplasm cytoplasmic region cytoskeletal protein binding cytoskeleton-dependent intracellular transport cytosol dendrite developmental process endocytosis establishment of localization in cell establishment of localization establishment of mitochondrion localization, microtubule-mediated establishment of mitochondrion localization establishment of organelle localization fusogenic activity guanyl nucleotide binding guanyl ribonucleotide binding heterocycle metabolic process heterocyclic compound binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides hydrolase activity import into cell inner mitochondrial membrane organization intracellular distribution of mitochondria intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle intracellular transport ion binding lipid binding localization magnesium ion binding membrane bending activity membrane fusion membrane organization membrane tubulation membrane-bounded organelle membrane-enclosed lumen membrane metabolic process metal ion binding microtubule binding microtubule-based movement microtubule-based process microtubule-based transport microtubule mitochondrial crista mitochondrial fission mitochondrial fusion mitochondrial genome maintenance mitochondrial inner membrane fusion mitochondrial inner membrane mitochondrial intermembrane space mitochondrial membrane organization mitochondrial membrane mitochondrial outer membrane mitochondrion distribution mitochondrion localization mitochondrion organization mitochondrion transport along microtubule mitochondrion molecular_function multicellular organismal process negative regulation of apoptotic process negative regulation of apoptotic signaling pathway negative regulation of biological process negative regulation of cell communication negative regulation of cellular component organization negative regulation of cellular process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of intracellular signal transduction negative regulation of intrinsic apoptotic signaling pathway negative regulation of mitochondrion organization negative regulation of organelle organization negative regulation of programmed cell death negative regulation of release of cytochrome c from mitochondria negative regulation of response to endoplasmic reticulum stress negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling nervous system process neural tube closure neuron projection cytoplasm neuron projection nitrogen compound metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleoplasm nucleoside phosphate binding nucleoside phosphate metabolic process nucleoside triphosphate metabolic process nucleotide binding nucleotide metabolic process organelle envelope lumen organelle fission organelle fusion organelle inner membrane organelle localization organelle lumen organelle membrane organelle organization organelle outer membrane organelle transport along microtubule organelle organic cyclic compound binding organic cyclic compound metabolic process organic substance metabolic process organonitrogen compound metabolic process organophosphate metabolic process outer membrane peroxisome fission phosphate-containing compound metabolic process phosphatidic acid binding phosphatidylglycerol binding phospholipid binding phosphorus metabolic process plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection polymeric cytoskeletal fiber positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of T cell activation positive regulation of T cell differentiation positive regulation of T-helper 17 cell differentiation positive regulation of T-helper 17 cell lineage commitment positive regulation of T-helper 17 type immune response positive regulation of T-helper cell differentiation positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell differentiation positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell development positive regulation of cell differentiation positive regulation of cell fate commitment positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of developmental process positive regulation of gene expression positive regulation of hemopoiesis positive regulation of immune effector process positive regulation of immune response positive regulation of immune system process positive regulation of interleukin-17 production positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte differentiation positive regulation of lymphocyte activation positive regulation of lymphocyte differentiation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of response to stimulus primary metabolic process programmed cell death protein binding protein complex oligomerization protein-containing complex assembly protein-containing complex organization purine nucleoside triphosphate metabolic process purine nucleotide binding purine nucleotide metabolic process purine ribonucleoside triphosphate binding purine ribonucleoside triphosphate metabolic process purine ribonucleotide binding purine ribonucleotide metabolic process purine-containing compound metabolic process pyrophosphatase activity regulation of CD4-positive, alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell differentiation regulation of T cell activation regulation of T cell differentiation regulation of T-helper 17 cell differentiation regulation of T-helper 17 cell lineage commitment regulation of T-helper 17 type immune response regulation of T-helper cell differentiation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of alpha-beta T cell activation regulation of alpha-beta T cell differentiation regulation of apoptotic process regulation of apoptotic signaling pathway regulation of biological process regulation of biosynthetic process regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell development regulation of cell differentiation regulation of cell fate commitment regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cellular response to stress regulation of cytokine production regulation of developmental process regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of gene expression regulation of hemopoiesis regulation of immune effector process regulation of immune response regulation of immune system process regulation of interleukin-17 production regulation of intracellular signal transduction regulation of intrinsic apoptotic signaling pathway regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of lymphocyte activation regulation of lymphocyte differentiation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of mitochondrion organization regulation of multicellular organismal development regulation of multicellular organismal process regulation of organelle organization regulation of programmed cell death regulation of release of cytochrome c from mitochondria regulation of response to endoplasmic reticulum stress regulation of response to stimulus regulation of response to stress regulation of signal transduction regulation of signaling ribonucleoside triphosphate metabolic process ribonucleoside triphosphate phosphatase activity ribonucleotide binding ribonucleotide metabolic process ribose phosphate metabolic process sensory perception of light stimulus sensory perception small molecule binding small molecule metabolic process supramolecular complex supramolecular fiber supramolecular polymer system process transport along microtubule transport tube closure tube formation tubulin binding vesicle-mediated transport visual perception	GO:0000002 GO:0000166 GO:0000266 GO:0000287 GO:0001817 GO:0001819 GO:0001843 GO:0002682 GO:0002684 GO:0002694 GO:0002696 GO:0002697 GO:0002699 GO:0002819 GO:0002821 GO:0002822 GO:0002824 GO:0003008 GO:0003674 GO:0003824 GO:0003924 GO:0005488 GO:0005515 GO:0005525 GO:0005543 GO:0005575 GO:0005654 GO:0005737 GO:0005739 GO:0005741 GO:0005743 GO:0005758 GO:0005829 GO:0005874 GO:0006139 GO:0006163 GO:0006725 GO:0006753 GO:0006793 GO:0006796 GO:0006807 GO:0006810 GO:0006897 GO:0006915 GO:0006996 GO:0007005 GO:0007006 GO:0007007 GO:0007017 GO:0007018 GO:0007600 GO:0007601 GO:0008017 GO:0008053 GO:0008088 GO:0008092 GO:0008150 GO:0008152 GO:0008219 GO:0008289 GO:0009117 GO:0009141 GO:0009144 GO:0009150 GO:0009199 GO:0009205 GO:0009259 GO:0009889 GO:0009891 GO:0009893 GO:0009966 GO:0009968 GO:0009987 GO:0010453 GO:0010455 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0010639 GO:0010646 GO:0010648 GO:0010720 GO:0010821 GO:0010823 GO:0010970 GO:0012501 GO:0015631 GO:0016020 GO:0016043 GO:0016192 GO:0016462 GO:0016559 GO:0016787 GO:0016817 GO:0016818 GO:0017076 GO:0017111 GO:0019001 GO:0019222 GO:0019637 GO:0019693 GO:0019866 GO:0019867 GO:0019896 GO:0022407 GO:0022409 GO:0022607 GO:0023051 GO:0023057 GO:0030061 GO:0030155 GO:0030425 GO:0030705 GO:0031090 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031966 GO:0031968 GO:0031970 GO:0031974 GO:0032501 GO:0032502 GO:0032553 GO:0032555 GO:0032561 GO:0032660 GO:0032740 GO:0032838 GO:0033043 GO:0034641 GO:0034643 GO:0035148 GO:0035639 GO:0036094 GO:0042407 GO:0042981 GO:0042995 GO:0043005 GO:0043066 GO:0043067 GO:0043069 GO:0043167 GO:0043168 GO:0043169 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0043370 GO:0043372 GO:0043933 GO:0044237 GO:0044238 GO:0044281 GO:0045580 GO:0045582 GO:0045595 GO:0045597 GO:0045619 GO:0045621 GO:0045622 GO:0045624 GO:0045785 GO:0046039 GO:0046483 GO:0046634 GO:0046635 GO:0046637 GO:0046638 GO:0046872 GO:0046907 GO:0047497 GO:0048284 GO:0048285 GO:0048311 GO:0048312 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048646 GO:0050776 GO:0050778 GO:0050789 GO:0050793 GO:0050794 GO:0050863 GO:0050865 GO:0050867 GO:0050870 GO:0050877 GO:0050953 GO:0051094 GO:0051128 GO:0051129 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0051249 GO:0051251 GO:0051259 GO:0051640 GO:0051641 GO:0051646 GO:0051649 GO:0051654 GO:0051656 GO:0055086 GO:0060255 GO:0060284 GO:0060606 GO:0061024 GO:0061025 GO:0065003 GO:0065007 GO:0070013 GO:0070300 GO:0071704 GO:0071840 GO:0072384 GO:0072521 GO:0080134 GO:0080135 GO:0090199 GO:0090201 GO:0090398 GO:0097159 GO:0097367 GO:0097749 GO:0098588 GO:0098657 GO:0098930 GO:0099080 GO:0099081 GO:0099111 GO:0099512 GO:0099513 GO:0099568 GO:0110165 GO:0120025 GO:0120111 GO:0140522 GO:0140523 GO:0180020 GO:1901135 GO:1901265 GO:1901360 GO:1901363 GO:1901564 GO:1901611 GO:1901612 GO:1902105 GO:1902107 GO:1902235 GO:1902236 GO:1902531 GO:1902532 GO:1903037 GO:1903039 GO:1903573 GO:1903706 GO:1903708 GO:1904115 GO:1905897 GO:1990627 GO:2000026 GO:2000316 GO:2000318 GO:2000319 GO:2000321 GO:2000328 GO:2000330 GO:2000514 GO:2000516 GO:2001233 GO:2001234 GO:2001242 GO:2001243
9361	lon peptidase 1, mitochondrial	LONP1	Homo sapiens (human)	9606	CODAS syndrome	DOID:0111274	ADP binding ATP binding ATP hydrolysis activity ATP-dependent activity ATP-dependent peptidase activity DNA binding DNA metabolic process DNA polymerase binding G-quadruplex DNA binding PH domain binding RNA binding adenyl nucleotide binding adenyl ribonucleotide binding anion binding binding biological regulation biological_process carbohydrate derivative binding catabolic process catalytic activity, acting on a protein catalytic activity cellular anatomical entity cellular aromatic compound metabolic process cellular component assembly cellular component organization or biogenesis cellular component organization cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular response to chemical stimulus cellular response to chemical stress cellular response to oxidative stress cellular response to stimulus cellular response to stress cellular_component chaperone-mediated protein complex assembly cytosol double-stranded DNA binding endopeptidase activity enzyme binding heterocycle metabolic process heterocyclic compound binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides hydrolase activity identical protein binding insulin receptor substrate binding intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle lumen intracellular organelle ion binding macromolecule catabolic process macromolecule metabolic process membrane-bounded organelle membrane-enclosed lumen membrane metabolic process mitochondrial DNA metabolic process mitochondrial genome maintenance mitochondrial matrix mitochondrial nucleoid mitochondrial promoter sequence-specific DNA binding mitochondrial protein catabolic process mitochondrion organization mitochondrion modification-dependent macromolecule catabolic process modification-dependent protein catabolic process molecular_function negative regulation of biological process negative regulation of cell communication negative regulation of cellular process negative regulation of cellular response to insulin stimulus negative regulation of insulin receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling nitrogen compound metabolic process non-membrane-bounded organelle nucleic acid binding nucleic acid metabolic process nucleobase-containing compound metabolic process nucleoid nucleoplasm nucleoside phosphate binding nucleotide binding organelle lumen organelle organization organelle organic cyclic compound binding organic cyclic compound metabolic process organic substance catabolic process organic substance metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process oxidation-dependent protein catabolic process peptidase activity primary metabolic process protein binding protein catabolic process protein domain specific binding protein metabolic process protein quality control for misfolded or incompletely synthesized proteins protein-containing complex assembly protein-containing complex organization proteolysis involved in protein catabolic process proteolysis purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding pyrophosphatase activity regulation of biological process regulation of cell communication regulation of cellular process regulation of cellular response to insulin stimulus regulation of insulin receptor signaling pathway regulation of response to stimulus regulation of signal transduction regulation of signaling response to abiotic stimulus response to aluminum ion response to chemical response to decreased oxygen levels response to endogenous stimulus response to hormone response to hypoxia response to inorganic substance response to metal ion response to organic substance response to oxidative stress response to oxygen levels response to stimulus response to stress ribonucleoside triphosphate phosphatase activity ribonucleotide binding sequence-specific DNA binding sequence-specific double-stranded DNA binding serine hydrolase activity serine-type endopeptidase activity serine-type peptidase activity single-stranded DNA binding single-stranded RNA binding small molecule binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding	GO:0000002 GO:0000166 GO:0000976 GO:0001018 GO:0001067 GO:0001666 GO:0003674 GO:0003676 GO:0003677 GO:0003690 GO:0003697 GO:0003723 GO:0003727 GO:0003824 GO:0004175 GO:0004176 GO:0004252 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005654 GO:0005739 GO:0005759 GO:0005829 GO:0006139 GO:0006259 GO:0006508 GO:0006515 GO:0006725 GO:0006807 GO:0006950 GO:0006979 GO:0006996 GO:0007005 GO:0008150 GO:0008152 GO:0008233 GO:0008236 GO:0009056 GO:0009057 GO:0009295 GO:0009628 GO:0009719 GO:0009725 GO:0009966 GO:0009968 GO:0009987 GO:0010033 GO:0010035 GO:0010038 GO:0010044 GO:0010646 GO:0010648 GO:0016020 GO:0016043 GO:0016462 GO:0016787 GO:0016817 GO:0016818 GO:0016887 GO:0017076 GO:0017111 GO:0017171 GO:0019538 GO:0019899 GO:0019904 GO:0019941 GO:0022607 GO:0023051 GO:0023057 GO:0030163 GO:0030554 GO:0031974 GO:0032042 GO:0032553 GO:0032555 GO:0032559 GO:0033554 GO:0034599 GO:0034641 GO:0035639 GO:0035694 GO:0036094 GO:0036293 GO:0042221 GO:0042645 GO:0042731 GO:0042802 GO:0043167 GO:0043168 GO:0043170 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043233 GO:0043531 GO:0043560 GO:0043565 GO:0043632 GO:0043933 GO:0044237 GO:0044238 GO:0046483 GO:0046626 GO:0046627 GO:0048519 GO:0048523 GO:0048583 GO:0048585 GO:0050789 GO:0050794 GO:0050896 GO:0051131 GO:0051603 GO:0051716 GO:0051880 GO:0062197 GO:0065003 GO:0065007 GO:0070013 GO:0070182 GO:0070407 GO:0070482 GO:0070887 GO:0071704 GO:0071840 GO:0090304 GO:0097159 GO:0097367 GO:0110165 GO:0140096 GO:0140657 GO:1900076 GO:1900077 GO:1901265 GO:1901360 GO:1901363 GO:1901564 GO:1901565 GO:1901575 GO:1990837
10000	AKT serine/threonine kinase 3	AKT3	Homo sapiens (human)	9606	colon cancer glioblastoma prostate adenocarcinoma prostate cancer renal cell carcinoma	DOID:10283 DOID:219 DOID:2526 DOID:3068 DOID:4450	3-phosphoinositide-dependent protein kinase activity AMP-activated protein kinase activity ATP binding DNA-dependent protein kinase activity Golgi apparatus Rho-dependent protein serine/threonine kinase activity adenyl nucleotide binding adenyl ribonucleotide binding anatomical structure homeostasis anatomical structure morphogenesis animal organ morphogenesis anion binding binding biological regulation biological_process brain morphogenesis carbohydrate derivative binding catalytic activity, acting on a protein catalytic activity cell projection cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular metabolic process cellular process cellular_component chromatin organization chromatin remodeling ciliary basal body cilium cytoplasm cytosol developmental process eukaryotic translation initiation factor 2alpha kinase activity heterocyclic compound binding histone H2A kinase activity histone H2AS1 kinase activity histone H2AS121 kinase activity histone H2AT120 kinase activity histone H2AX kinase activity histone H2AXS139 kinase activity histone H2B kinase activity histone H2BS14 kinase activity histone H2BS36 kinase activity histone H3 kinase activity histone H3S10 kinase activity histone H3S28 kinase activity histone H3S57 kinase activity histone H3T11 kinase activity histone H3T3 kinase activity histone H3T45 kinase activity histone H3T6 kinase activity histone H4 kinase activity histone H4S1 kinase activity histone kinase activity histone modifying activity homeostasis of number of cells within a tissue homeostasis of number of cells homeostatic process intracellular membrane-bounded organelle intracellular organelle intracellular signal transduction ion binding kinase activity macromolecule metabolic process macromolecule modification membrane-bounded organelle membrane metabolic process microtubule organizing center mitochondrial genome maintenance mitochondrion organization molecular_function multicellular organismal process multicellular organismal-level homeostasis negative regulation of PERK-mediated unfolded protein response negative regulation of biological process negative regulation of cell communication negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of cellular senescence negative regulation of endoplasmic reticulum unfolded protein response negative regulation of metabolic process negative regulation of response to endoplasmic reticulum stress negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling nitrogen compound metabolic process nucleoplasm nucleoside phosphate binding nucleotide binding organelle organization organelle organic cyclic compound binding organic substance metabolic process organonitrogen compound metabolic process phosphate-containing compound metabolic process phosphorus metabolic process phosphorylation phosphotransferase activity, alcohol group as acceptor plasma membrane bounded cell projection plasma membrane positive regulation of TOR signaling positive regulation of angiogenesis positive regulation of artery morphogenesis positive regulation of biological process positive regulation of blood vessel endothelial cell migration positive regulation of cell communication positive regulation of cell migration involved in sprouting angiogenesis positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cell size positive regulation of cellular process positive regulation of developmental process positive regulation of endothelial cell migration positive regulation of endothelial cell proliferation positive regulation of epithelial cell migration positive regulation of epithelial cell proliferation positive regulation of intracellular signal transduction positive regulation of locomotion positive regulation of multicellular organismal process positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of vascular endothelial cell proliferation positive regulation of vasculature development primary metabolic process protein binding protein kinase activity protein metabolic process protein modification process protein phosphorylation protein serine kinase activity protein serine/threonine kinase activity protein-DNA complex organization protein-containing complex organization purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding regulation of PERK-mediated unfolded protein response regulation of TOR signaling regulation of anatomical structure morphogenesis regulation of anatomical structure size regulation of angiogenesis regulation of artery morphogenesis regulation of biological process regulation of biological quality regulation of blood vessel endothelial cell migration regulation of cell communication regulation of cell migration involved in sprouting angiogenesis regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cell size regulation of cellular component size regulation of cellular metabolic process regulation of cellular process regulation of cellular response to stress regulation of cellular senescence regulation of developmental process regulation of endoplasmic reticulum unfolded protein response regulation of endothelial cell migration regulation of endothelial cell proliferation regulation of epithelial cell migration regulation of epithelial cell proliferation regulation of intracellular signal transduction regulation of locomotion regulation of metabolic process regulation of multicellular organismal development regulation of multicellular organismal process regulation of response to endoplasmic reticulum stress regulation of response to stimulus regulation of response to stress regulation of signal transduction regulation of signaling regulation of vascular endothelial cell proliferation regulation of vasculature development ribonucleotide binding ribosomal protein S6 kinase activity signal transduction small molecule binding tissue homeostasis transferase activity, transferring phosphorus-containing groups transferase activity	GO:0000002 GO:0000166 GO:0001894 GO:0001936 GO:0001938 GO:0003674 GO:0003824 GO:0004672 GO:0004674 GO:0004676 GO:0004677 GO:0004679 GO:0004694 GO:0004711 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005654 GO:0005737 GO:0005794 GO:0005815 GO:0005829 GO:0005886 GO:0005929 GO:0006325 GO:0006338 GO:0006468 GO:0006793 GO:0006796 GO:0006807 GO:0006996 GO:0007005 GO:0007165 GO:0008150 GO:0008152 GO:0008284 GO:0008361 GO:0009653 GO:0009887 GO:0009892 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010594 GO:0010595 GO:0010632 GO:0010634 GO:0010646 GO:0010647 GO:0010648 GO:0016020 GO:0016043 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0016773 GO:0017076 GO:0019222 GO:0019538 GO:0022603 GO:0023051 GO:0023056 GO:0023057 GO:0030334 GO:0030335 GO:0030554 GO:0031323 GO:0031324 GO:0032006 GO:0032008 GO:0032501 GO:0032502 GO:0032535 GO:0032553 GO:0032555 GO:0032559 GO:0035173 GO:0035175 GO:0035402 GO:0035403 GO:0035556 GO:0035639 GO:0035979 GO:0036064 GO:0036094 GO:0036211 GO:0040012 GO:0040017 GO:0042127 GO:0042592 GO:0042995 GO:0043167 GO:0043168 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043412 GO:0043535 GO:0043536 GO:0043933 GO:0044022 GO:0044023 GO:0044024 GO:0044025 GO:0044237 GO:0044238 GO:0045765 GO:0045766 GO:0045793 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048854 GO:0048871 GO:0048872 GO:0048873 GO:0050678 GO:0050679 GO:0050789 GO:0050793 GO:0050794 GO:0051094 GO:0051239 GO:0051240 GO:0060249 GO:0065007 GO:0065008 GO:0071704 GO:0071824 GO:0071840 GO:0072354 GO:0072371 GO:0072518 GO:0080134 GO:0080135 GO:0090049 GO:0090050 GO:0090066 GO:0097159 GO:0097367 GO:0106310 GO:0110165 GO:0120025 GO:0140096 GO:0140823 GO:0140855 GO:0140857 GO:0140993 GO:0140995 GO:0140996 GO:0140997 GO:0140998 GO:0141003 GO:1900101 GO:1900102 GO:1901265 GO:1901342 GO:1901363 GO:1901564 GO:1902531 GO:1902533 GO:1903573 GO:1903897 GO:1903898 GO:1904018 GO:1905562 GO:1905564 GO:1905651 GO:1905653 GO:1905897 GO:1990244 GO:2000026 GO:2000145 GO:2000147 GO:2000772 GO:2000773
84275	solute carrier family 25 member 33	SLC25A33	Homo sapiens (human)	9606			DNA-templated transcription RNA biosynthetic process RNA metabolic process aromatic compound biosynthetic process biological regulation biological_process biosynthetic process cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular component assembly cellular component organization or biogenesis cellular component organization cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular response to chemical stimulus cellular response to endogenous stimulus cellular response to hormone stimulus cellular response to insulin stimulus cellular response to insulin-like growth factor stimulus cellular response to nitrogen compound cellular response to organic substance cellular response to organonitrogen compound cellular response to oxygen-containing compound cellular response to peptide hormone stimulus cellular response to peptide cellular response to stimulus cellular_component cytochrome complex assembly establishment of localization heterocycle biosynthetic process heterocycle metabolic process intracellular membrane-bounded organelle intracellular organelle localization macromolecule biosynthetic process macromolecule metabolic process membrane-bounded organelle membrane metabolic process mitochondria-nucleus signaling pathway mitochondrial RNA metabolic process mitochondrial genome maintenance mitochondrial inner membrane mitochondrial membrane mitochondrial respiratory chain complex III assembly mitochondrial respiratory chain complex assembly mitochondrial transcription mitochondrial transmembrane transport mitochondrial transport mitochondrion organization mitochondrion molecular_function nitrogen compound metabolic process nitrogen compound transport nucleic acid metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleobase-containing compound transmembrane transporter activity nucleobase-containing compound transport nucleotide transmembrane transport nucleotide transmembrane transporter activity nucleotide transport organelle inner membrane organelle membrane organelle organization organelle organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process organic substance transport organophosphate ester transmembrane transporter activity organophosphate ester transport positive regulation of biological process positive regulation of cell growth positive regulation of cell population proliferation positive regulation of cellular process positive regulation of growth primary metabolic process protein-containing complex assembly protein-containing complex organization pyrimidine nucleotide import into mitochondrion pyrimidine nucleotide transmembrane transporter activity pyrimidine nucleotide transport pyrimidine-containing compound transmembrane transport regulation of aerobic respiration regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of cell growth regulation of cell population proliferation regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cellular respiration regulation of generation of precursor metabolites and energy regulation of growth regulation of membrane potential regulation of metabolic process regulation of mitochondrial membrane potential regulation of oxidative phosphorylation regulation of reactive oxygen species biosynthetic process regulation of reactive oxygen species metabolic process respiratory chain complex III assembly response to chemical response to endogenous stimulus response to hormone response to insulin response to nitrogen compound response to organic substance response to organonitrogen compound response to oxygen-containing compound response to peptide hormone response to peptide response to stimulus signal transduction transmembrane transport transmembrane transporter activity transport transporter activity	GO:0000002 GO:0000959 GO:0001558 GO:0002082 GO:0003674 GO:0005215 GO:0005575 GO:0005739 GO:0005743 GO:0006139 GO:0006351 GO:0006390 GO:0006725 GO:0006807 GO:0006810 GO:0006839 GO:0006862 GO:0006864 GO:0006996 GO:0007005 GO:0007165 GO:0008150 GO:0008152 GO:0008284 GO:0009058 GO:0009059 GO:0009719 GO:0009725 GO:0009889 GO:0009987 GO:0010033 GO:0010243 GO:0015215 GO:0015218 GO:0015605 GO:0015748 GO:0015931 GO:0015932 GO:0016020 GO:0016043 GO:0016070 GO:0017004 GO:0017062 GO:0018130 GO:0019222 GO:0019438 GO:0019866 GO:0022607 GO:0022857 GO:0030307 GO:0031090 GO:0031323 GO:0031930 GO:0031966 GO:0032774 GO:0032868 GO:0032869 GO:0032870 GO:0033108 GO:0034551 GO:0034641 GO:0034654 GO:0040008 GO:0042127 GO:0042221 GO:0042391 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043434 GO:0043457 GO:0043467 GO:0043933 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0045927 GO:0046483 GO:0048518 GO:0048522 GO:0050789 GO:0050794 GO:0050896 GO:0051128 GO:0051179 GO:0051234 GO:0051716 GO:0051881 GO:0055085 GO:0065003 GO:0065007 GO:0065008 GO:0070887 GO:0071310 GO:0071375 GO:0071417 GO:0071495 GO:0071702 GO:0071704 GO:0071705 GO:0071840 GO:0072531 GO:0090304 GO:0110165 GO:1901360 GO:1901362 GO:1901576 GO:1901652 GO:1901653 GO:1901679 GO:1901698 GO:1901699 GO:1901700 GO:1901701 GO:1903426 GO:1903715 GO:1990314 GO:1990519 GO:1990542 GO:2000377
1890	thymidine phosphorylase	TYMP Aliases: gliostatin	Homo sapiens (human)	9606	lung non-small cell carcinoma mitochondrial DNA depletion syndrome 1 mitochondrial encephalomyopathy pancreatic cancer transitional cell carcinoma	DOID:0080119 DOID:1793 DOID:2671 DOID:3908 DOID:890	1,4-alpha-oligoglucan phosphorylase activity 2'-deoxyribonucleotide metabolic process anatomical structure formation involved in morphogenesis angiogenesis aromatic compound catabolic process binding biological regulation biological_process carbohydrate derivative catabolic process carbohydrate derivative metabolic process catabolic process catalytic activity cell differentiation cellular anatomical entity cellular aromatic compound metabolic process cellular catabolic process cellular component organization or biogenesis cellular component organization cellular developmental process cellular metabolic process cellular nitrogen compound catabolic process cellular nitrogen compound metabolic process cellular process cellular_component chemotaxis cytosol dTMP catabolic process dTMP metabolic process deoxyribonucleoside monophosphate catabolic process deoxyribonucleoside monophosphate metabolic process deoxyribonucleotide catabolic process deoxyribonucleotide metabolic process deoxyribose phosphate catabolic process deoxyribose phosphate metabolic process developmental process glycosyl compound metabolic process glycosyltransferase activity growth factor activity heterocycle catabolic process heterocycle metabolic process hexosyltransferase activity identical protein binding locomotion metabolic process mitochondrial genome maintenance mitochondrion organization molecular function activator activity molecular function regulator activity molecular_function nitrogen compound metabolic process nucleobase metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleoside metabolic process nucleoside monophosphate catabolic process nucleoside monophosphate metabolic process nucleoside phosphate catabolic process nucleoside phosphate metabolic process nucleotide catabolic process nucleotide metabolic process organelle organization organic cyclic compound catabolic process organic cyclic compound metabolic process organic substance catabolic process organic substance metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process organophosphate catabolic process organophosphate metabolic process pentosyltransferase activity phosphate-containing compound metabolic process phosphorus metabolic process primary metabolic process protein binding protein dimerization activity protein homodimerization activity pyrimidine deoxyribonucleoside monophosphate catabolic process pyrimidine deoxyribonucleoside monophosphate metabolic process pyrimidine deoxyribonucleotide catabolic process pyrimidine deoxyribonucleotide metabolic process pyrimidine nucleobase metabolic process pyrimidine nucleoside metabolic process pyrimidine nucleoside monophosphate catabolic process pyrimidine nucleoside monophosphate metabolic process pyrimidine nucleotide catabolic process pyrimidine nucleotide metabolic process pyrimidine-containing compound catabolic process pyrimidine-containing compound metabolic process receptor ligand activity regulation of biological process regulation of cell communication regulation of cellular process regulation of developmental process regulation of digestive system process regulation of gastric motility regulation of multicellular organismal development regulation of multicellular organismal process regulation of myelination regulation of nervous system development regulation of nervous system process regulation of system process regulation of transmission of nerve impulse signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity small molecule metabolic process taxis thymidine phosphorylase activity transferase activity	GO:0000002 GO:0001525 GO:0003674 GO:0003824 GO:0004645 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005829 GO:0006139 GO:0006206 GO:0006213 GO:0006220 GO:0006244 GO:0006725 GO:0006753 GO:0006793 GO:0006796 GO:0006807 GO:0006935 GO:0006996 GO:0007005 GO:0007165 GO:0008083 GO:0008150 GO:0008152 GO:0009032 GO:0009056 GO:0009112 GO:0009116 GO:0009117 GO:0009123 GO:0009125 GO:0009129 GO:0009131 GO:0009159 GO:0009162 GO:0009166 GO:0009176 GO:0009178 GO:0009219 GO:0009223 GO:0009262 GO:0009264 GO:0009394 GO:0009987 GO:0010646 GO:0016043 GO:0016740 GO:0016757 GO:0016758 GO:0016763 GO:0019439 GO:0019637 GO:0019692 GO:0030154 GO:0030545 GO:0030546 GO:0031641 GO:0031644 GO:0032502 GO:0034641 GO:0034655 GO:0040011 GO:0042330 GO:0042802 GO:0042803 GO:0044057 GO:0044058 GO:0044237 GO:0044238 GO:0044248 GO:0044270 GO:0044281 GO:0046073 GO:0046074 GO:0046386 GO:0046434 GO:0046483 GO:0046700 GO:0046983 GO:0048018 GO:0048646 GO:0048869 GO:0050789 GO:0050793 GO:0050794 GO:0051239 GO:0051960 GO:0051969 GO:0055086 GO:0065007 GO:0071704 GO:0071840 GO:0072527 GO:0072529 GO:0098772 GO:0110165 GO:0140677 GO:1901135 GO:1901136 GO:1901292 GO:1901360 GO:1901361 GO:1901564 GO:1901565 GO:1901575 GO:1901657 GO:1905333 GO:2000026
6742	single stranded DNA binding protein 1	SSBP1	Homo sapiens (human)	9606	optic atrophy	DOID:5723	DNA binding DNA conformation change DNA duplex unwinding DNA geometric change DNA metabolic process DNA replication DNA unwinding involved in DNA replication DNA-templated DNA replication RNA binding binding biological regulation biological_process cellular anatomical entity cellular aromatic compound metabolic process cellular component assembly cellular component organization or biogenesis cellular component organization cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular_component chromatin binding chromosome organization enzyme activator activity enzyme regulator activity extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle heterocycle metabolic process identical protein binding intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle lumen intracellular organelle macromolecule metabolic process membrane-bounded organelle membrane-enclosed lumen metabolic process mitochondrial DNA metabolic process mitochondrial DNA replication mitochondrial genome maintenance mitochondrial matrix mitochondrial nucleoid mitochondrion organization mitochondrion molecular function activator activity molecular function regulator activity molecular_function nitrogen compound metabolic process non-membrane-bounded organelle nucleic acid binding nucleic acid metabolic process nucleobase-containing compound metabolic process nucleoid nucleus organelle lumen organelle organization organelle organic cyclic compound binding organic cyclic compound metabolic process organic substance metabolic process positive regulation of ATP-dependent activity positive regulation of DNA metabolic process positive regulation of DNA replication positive regulation of DNA-templated DNA replication positive regulation of biological process positive regulation of catalytic activity positive regulation of cellular component organization positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of helicase activity positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of mitochondrial DNA metabolic process positive regulation of mitochondrial DNA replication positive regulation of mitochondrion organization positive regulation of molecular function positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of organelle organization primary metabolic process protein binding protein complex oligomerization protein dimerization activity protein homodimerization activity protein homooligomerization protein homotetramerization protein tetramerization protein-containing complex assembly protein-containing complex binding protein-containing complex organization regulation of ATP-dependent activity regulation of DNA metabolic process regulation of DNA replication regulation of DNA-templated DNA replication regulation of biological process regulation of catalytic activity regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of helicase activity regulation of macromolecule metabolic process regulation of metabolic process regulation of mitochondrial DNA metabolic process regulation of mitochondrial DNA replication regulation of mitochondrion organization regulation of molecular function regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of organelle organization regulation of primary metabolic process single-stranded DNA binding vesicle	GO:0000002 GO:0003674 GO:0003676 GO:0003677 GO:0003682 GO:0003697 GO:0003723 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005739 GO:0005759 GO:0006139 GO:0006259 GO:0006260 GO:0006261 GO:0006264 GO:0006268 GO:0006275 GO:0006725 GO:0006807 GO:0006996 GO:0007005 GO:0008047 GO:0008150 GO:0008152 GO:0009295 GO:0009893 GO:0009987 GO:0010604 GO:0010638 GO:0010821 GO:0010822 GO:0016043 GO:0019219 GO:0019222 GO:0022607 GO:0030234 GO:0031323 GO:0031325 GO:0031974 GO:0031982 GO:0032042 GO:0032392 GO:0032508 GO:0032781 GO:0033043 GO:0034641 GO:0042645 GO:0042802 GO:0042803 GO:0043085 GO:0043170 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043230 GO:0043231 GO:0043232 GO:0043233 GO:0043462 GO:0043933 GO:0044093 GO:0044237 GO:0044238 GO:0044877 GO:0045740 GO:0045935 GO:0046483 GO:0046983 GO:0048518 GO:0048522 GO:0050789 GO:0050790 GO:0050794 GO:0051052 GO:0051054 GO:0051095 GO:0051096 GO:0051128 GO:0051130 GO:0051171 GO:0051173 GO:0051259 GO:0051260 GO:0051262 GO:0051276 GO:0051289 GO:0060255 GO:0065003 GO:0065007 GO:0065009 GO:0065010 GO:0070013 GO:0070062 GO:0071103 GO:0071704 GO:0071840 GO:0080090 GO:0090296 GO:0090297 GO:0090304 GO:0090329 GO:0097159 GO:0098772 GO:0110165 GO:0140677 GO:1901360 GO:1901858 GO:1901860 GO:1903561 GO:2000105
6774	signal transducer and activator of transcription 3	STAT3	Homo sapiens (human)	9606	Alzheimer's disease Behcet's disease Crohn's disease angiosarcoma breast cancer colon adenocarcinoma esophageal carcinoma head and neck squamous cell carcinoma hyper IgE recurrent infection syndrome 1 lymphoproliferative syndrome obesity ovarian cancer prostate cancer prostate carcinoma psoriasis psoriatic arthritis rectum adenocarcinoma renal cell carcinoma rheumatoid arthritis squamous cell carcinoma type 2 diabetes mellitus ulcerative colitis	DOID:0001816 DOID:0060704 DOID:10283 DOID:10286 DOID:10652 DOID:1107 DOID:13241 DOID:1612 DOID:1749 DOID:1996 DOID:234 DOID:2394 DOID:3261 DOID:4450 DOID:5520 DOID:7148 DOID:8577 DOID:8778 DOID:8893 DOID:9008 DOID:9352 DOID:9970	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment CD4-positive, alpha-beta T cell lineage commitment DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor binding DNA-templated transcription RNA binding RNA biosynthetic process RNA metabolic process RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulator complex RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding RNA sequestering activity T cell lineage commitment T-helper 17 cell lineage commitment T-helper 17 type immune response T-helper cell lineage commitment adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains adaptive immune response alpha-beta T cell lineage commitment anatomical structure development aromatic compound biosynthetic process astrocyte differentiation behavior binding biological regulation biological_process biosynthetic process camera-type eye photoreceptor cell differentiation carbohydrate homeostasis cell differentiation cell fate commitment cell population proliferation cell surface receptor signaling pathway cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular developmental process cellular localization cellular macromolecule localization cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to endogenous stimulus cellular response to hormone stimulus cellular response to interleukin-17 cellular response to leptin stimulus cellular response to organic substance cellular response to stimulus cellular_component chemical homeostasis chromatin DNA binding chromatin binding chromatin cis-regulatory region sequence-specific DNA binding cytokine-mediated signaling pathway cytoplasm cytosol defense response developmental process double-stranded DNA binding eating behavior energy homeostasis enzyme binding enzyme-linked receptor protein signaling pathway establishment of localization in cell establishment of localization establishment of protein localization to organelle establishment of protein localization eye photoreceptor cell differentiation feeding behavior glial cell differentiation glucose homeostasis growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway heterocycle biosynthetic process heterocycle metabolic process homeostatic process identical protein binding immune response immune system process import into nucleus inflammatory response interleukin-10-mediated signaling pathway interleukin-11-mediated signaling pathway interleukin-15-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-23-mediated signaling pathway interleukin-6-mediated signaling pathway interleukin-9-mediated signaling pathway intracellular membrane-bounded organelle intracellular organelle intracellular protein transport intracellular receptor signaling pathway intracellular signal transduction intracellular transport kinase binding leptin-mediated signaling pathway ligand-activated transcription factor activity lncRNA binding localization mRNA metabolic process mRNA transcription by RNA polymerase II mRNA transcription macromolecule biosynthetic process macromolecule localization macromolecule metabolic process maintenance of cell number membrane-bounded organelle membrane metabolic process molecular adaptor activity molecular sequestering activity molecular transducer activity molecular_function multicellular organismal process multicellular organismal-level homeostasis negative regulation of ATP metabolic process negative regulation of DNA-templated transcription negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of autophagy negative regulation of biological process negative regulation of biosynthetic process negative regulation of canonical NF-kappaB signal transduction negative regulation of carbohydrate metabolic process negative regulation of catabolic process negative regulation of cell communication negative regulation of cell differentiation negative regulation of cell migration negative regulation of cell motility negative regulation of cell population proliferation negative regulation of cellular biosynthetic process negative regulation of cellular catabolic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of cytokine production involved in inflammatory response negative regulation of cytokine production negative regulation of defense response negative regulation of developmental process negative regulation of gene expression negative regulation of gene silencing by regulatory ncRNA negative regulation of glycolytic process negative regulation of inflammatory response to wounding negative regulation of inflammatory response negative regulation of intracellular signal transduction negative regulation of locomotion negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of miRNA processing negative regulation of miRNA-mediated gene silencing negative regulation of multicellular organismal process negative regulation of neuron migration negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of nucleotide catabolic process negative regulation of nucleotide metabolic process negative regulation of phosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of post-transcriptional gene silencing by regulatory ncRNA negative regulation of post-transcriptional gene silencing negative regulation of primary miRNA processing negative regulation of purine nucleotide catabolic process negative regulation of purine nucleotide metabolic process negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of response to wounding negative regulation of signal transduction negative regulation of signaling negative regulation of small molecule metabolic process negative regulation of stem cell differentiation negative regulation of transcription by RNA polymerase II nervous system development neuron differentiation nitrogen compound metabolic process nitrogen compound transport nuclear protein-containing complex nuclear receptor activity nuclear transport nucleic acid binding nucleic acid metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleocytoplasmic transport nucleoplasm nucleus organelle organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process organic substance transport phosphatase binding phosphate-containing compound metabolic process phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphorus metabolic process phosphorylation photoreceptor cell differentiation plasma membrane positive regulation of DNA-templated transcription positive regulation of Notch signaling pathway positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of angiogenesis positive regulation of biological process positive regulation of biosynthetic process positive regulation of canonical NF-kappaB signal transduction positive regulation of catalytic activity positive regulation of cell communication positive regulation of cell differentiation positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cellular biosynthetic process positive regulation of cellular component organization positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production involved in inflammatory response positive regulation of cytokine production positive regulation of developmental process positive regulation of endocytosis positive regulation of endopeptidase activity positive regulation of endothelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of erythrocyte differentiation positive regulation of gene expression positive regulation of hydrolase activity positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of intracellular signal transduction positive regulation of locomotion positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of metalloendopeptidase activity positive regulation of metallopeptidase activity positive regulation of miRNA metabolic process positive regulation of miRNA transcription positive regulation of molecular function positive regulation of multicellular organismal process positive regulation of myeloid cell differentiation positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of peptidase activity positive regulation of phagocytosis positive regulation of protein metabolic process positive regulation of proteolysis positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of transcription by RNA polymerase II positive regulation of transport positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of vascular endothelial cell proliferation positive regulation of vascular endothelial growth factor production positive regulation of vasculature development primary metabolic process primary miRNA binding protein binding protein dimerization activity protein homodimerization activity protein import into nucleus protein kinase binding protein localization to nucleus protein localization to organelle protein localization protein phosphatase binding protein sequestering activity protein transport protein-DNA complex protein-containing complex binding protein-containing complex protein-macromolecule adaptor activity radial glial cell differentiation receptor signaling pathway via JAK-STAT receptor signaling pathway via STAT regulation of ATP metabolic process regulation of DNA-templated transcription regulation of Notch signaling pathway regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of anatomical structure morphogenesis regulation of angiogenesis regulation of autophagy regulation of behavior regulation of biological process regulation of biosynthetic process regulation of canonical NF-kappaB signal transduction regulation of carbohydrate catabolic process regulation of carbohydrate metabolic process regulation of catabolic process regulation of catalytic activity regulation of cell communication regulation of cell cycle regulation of cell development regulation of cell differentiation regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular catabolic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cytokine production involved in inflammatory response regulation of cytokine production regulation of defense response regulation of developmental growth regulation of developmental process regulation of endocytosis regulation of endopeptidase activity regulation of endothelial cell proliferation regulation of epithelial cell proliferation regulation of erythrocyte differentiation regulation of feeding behavior regulation of gene expression regulation of gene silencing by regulatory ncRNA regulation of generation of precursor metabolites and energy regulation of glycolytic process regulation of growth regulation of hemopoiesis regulation of hydrolase activity regulation of immune system process regulation of inflammatory response to wounding regulation of inflammatory response regulation of interleukin-1 beta production regulation of interleukin-1 production regulation of interleukin-10 production regulation of interleukin-6 production regulation of interleukin-8 production regulation of intracellular signal transduction regulation of localization regulation of locomotion regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of metalloendopeptidase activity regulation of metallopeptidase activity regulation of miRNA metabolic process regulation of miRNA processing regulation of miRNA transcription regulation of miRNA-mediated gene silencing regulation of molecular function regulation of multicellular organism growth regulation of multicellular organismal development regulation of multicellular organismal process regulation of myeloid cell differentiation regulation of ncRNA transcription regulation of neuron migration regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of nucleotide catabolic process regulation of nucleotide metabolic process regulation of peptidase activity regulation of phagocytosis regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of post-transcriptional gene silencing regulation of primary metabolic process regulation of primary miRNA processing regulation of protein metabolic process regulation of proteolysis regulation of purine nucleotide catabolic process regulation of purine nucleotide metabolic process regulation of regulatory ncRNA processing regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of response to wounding regulation of signal transduction regulation of signaling regulation of small molecule metabolic process regulation of stem cell differentiation regulation of transcription by RNA polymerase II regulation of transport regulation of tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of vascular endothelial cell proliferation regulation of vascular endothelial growth factor production regulation of vasculature development regulation of vesicle-mediated transport reproduction response to chemical response to cytokine response to endogenous stimulus response to estradiol response to hormone response to interleukin-17 response to leptin response to lipid response to nitrogen compound response to organic cyclic compound response to organic substance response to organonitrogen compound response to oxygen-containing compound response to peptide hormone response to peptide response to stimulus response to stress retinal rod cell differentiation sequence-specific DNA binding sequence-specific double-stranded DNA binding sexual reproduction signal transduction signaling adaptor activity signaling receptor activity signaling receptor binding somatic stem cell population maintenance stem cell population maintenance system development temperature homeostasis transcription by RNA polymerase II transcription cis-regulatory region binding transcription factor binding transcription regulator activity transcription regulator complex transcription regulatory region nucleic acid binding transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor superfamily signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway transport	GO:0000003 GO:0000122 GO:0000785 GO:0000976 GO:0000977 GO:0000978 GO:0000981 GO:0000987 GO:0001067 GO:0001216 GO:0001228 GO:0001659 GO:0001754 GO:0001817 GO:0001818 GO:0001819 GO:0001936 GO:0001938 GO:0002250 GO:0002295 GO:0002360 GO:0002363 GO:0002376 GO:0002460 GO:0002682 GO:0003674 GO:0003676 GO:0003677 GO:0003682 GO:0003690 GO:0003700 GO:0003723 GO:0004879 GO:0005102 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005667 GO:0005737 GO:0005829 GO:0005886 GO:0006109 GO:0006110 GO:0006139 GO:0006140 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0006606 GO:0006725 GO:0006793 GO:0006796 GO:0006807 GO:0006810 GO:0006886 GO:0006913 GO:0006950 GO:0006952 GO:0006954 GO:0006955 GO:0007165 GO:0007166 GO:0007167 GO:0007169 GO:0007178 GO:0007179 GO:0007259 GO:0007399 GO:0007610 GO:0007631 GO:0008104 GO:0008134 GO:0008150 GO:0008152 GO:0008283 GO:0008284 GO:0008285 GO:0008593 GO:0009058 GO:0009059 GO:0009299 GO:0009719 GO:0009725 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009894 GO:0009895 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0010001 GO:0010033 GO:0010243 GO:0010468 GO:0010506 GO:0010507 GO:0010556 GO:0010557 GO:0010558 GO:0010563 GO:0010574 GO:0010575 GO:0010604 GO:0010605 GO:0010628 GO:0010629 GO:0010646 GO:0010647 GO:0010648 GO:0010950 GO:0010952 GO:0014070 GO:0015031 GO:0016020 GO:0016070 GO:0016071 GO:0016310 GO:0018130 GO:0019219 GO:0019220 GO:0019221 GO:0019222 GO:0019438 GO:0019827 GO:0019899 GO:0019900 GO:0019901 GO:0019902 GO:0019903 GO:0019953 GO:0022603 GO:0023051 GO:0023056 GO:0023057 GO:0030100 GO:0030154 GO:0030162 GO:0030182 GO:0030334 GO:0030335 GO:0030336 GO:0030522 GO:0030674 GO:0030811 GO:0030812 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031329 GO:0031330 GO:0031347 GO:0031348 GO:0031490 GO:0032101 GO:0032102 GO:0032355 GO:0032501 GO:0032502 GO:0032651 GO:0032652 GO:0032653 GO:0032675 GO:0032677 GO:0032680 GO:0032731 GO:0032732 GO:0032733 GO:0032755 GO:0032757 GO:0032760 GO:0032774 GO:0032870 GO:0032879 GO:0032991 GO:0032993 GO:0033036 GO:0033121 GO:0033122 GO:0033210 GO:0033365 GO:0033500 GO:0033993 GO:0034097 GO:0034504 GO:0034641 GO:0034654 GO:0035019 GO:0035556 GO:0035591 GO:0035723 GO:0038023 GO:0038110 GO:0038113 GO:0038154 GO:0038155 GO:0040008 GO:0040012 GO:0040013 GO:0040014 GO:0040017 GO:0042127 GO:0042221 GO:0042592 GO:0042593 GO:0042755 GO:0042789 GO:0042802 GO:0042803 GO:0043085 GO:0043122 GO:0043123 GO:0043124 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043369 GO:0043373 GO:0043434 GO:0043467 GO:0043470 GO:0043491 GO:0043565 GO:0044093 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0044320 GO:0044321 GO:0044877 GO:0045165 GO:0045184 GO:0045595 GO:0045596 GO:0045597 GO:0045637 GO:0045639 GO:0045646 GO:0045648 GO:0045747 GO:0045765 GO:0045766 GO:0045807 GO:0045820 GO:0045862 GO:0045892 GO:0045893 GO:0045912 GO:0045934 GO:0045935 GO:0045936 GO:0045944 GO:0045980 GO:0046483 GO:0046530 GO:0046907 GO:0046983 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048638 GO:0048708 GO:0048731 GO:0048856 GO:0048869 GO:0048871 GO:0048878 GO:0050678 GO:0050679 GO:0050727 GO:0050728 GO:0050764 GO:0050766 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050795 GO:0050896 GO:0051049 GO:0051050 GO:0051093 GO:0051094 GO:0051128 GO:0051130 GO:0051169 GO:0051170 GO:0051171 GO:0051172 GO:0051173 GO:0051174 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051246 GO:0051247 GO:0051252 GO:0051253 GO:0051254 GO:0051336 GO:0051345 GO:0051641 GO:0051649 GO:0051716 GO:0051726 GO:0052547 GO:0052548 GO:0060019 GO:0060089 GO:0060090 GO:0060147 GO:0060149 GO:0060219 GO:0060221 GO:0060255 GO:0060259 GO:0060284 GO:0060396 GO:0060397 GO:0060627 GO:0060964 GO:0060965 GO:0060966 GO:0060967 GO:0061629 GO:0062012 GO:0062014 GO:0065007 GO:0065009 GO:0070102 GO:0070727 GO:0070878 GO:0070887 GO:0070920 GO:0071310 GO:0071345 GO:0071495 GO:0071702 GO:0071704 GO:0071705 GO:0072538 GO:0072540 GO:0072594 GO:0080090 GO:0080134 GO:0090304 GO:0090575 GO:0097009 GO:0097159 GO:0097396 GO:0097398 GO:0097696 GO:0098531 GO:0098727 GO:0106014 GO:0106015 GO:0106222 GO:0110165 GO:0140105 GO:0140110 GO:0140297 GO:0140311 GO:0140313 GO:0140513 GO:0140610 GO:0140747 GO:0141091 GO:1900015 GO:1900016 GO:1900017 GO:1900368 GO:1900369 GO:1900542 GO:1900543 GO:1901342 GO:1901360 GO:1901362 GO:1901576 GO:1901652 GO:1901698 GO:1901700 GO:1902531 GO:1902532 GO:1902533 GO:1902679 GO:1902680 GO:1902893 GO:1902895 GO:1903034 GO:1903035 GO:1903555 GO:1903557 GO:1903578 GO:1903579 GO:1903706 GO:1903798 GO:1903799 GO:1904018 GO:1904683 GO:1904685 GO:1905048 GO:1905050 GO:1905562 GO:1905564 GO:1990837 GO:2000026 GO:2000145 GO:2000146 GO:2000147 GO:2000628 GO:2000630 GO:2000634 GO:2000635 GO:2000736 GO:2000737 GO:2001141 GO:2001222 GO:2001223
3952	leptin	LEP	Homo sapiens (human)	9606	adult respiratory distress syndrome alcohol dependence alcoholic liver cirrhosis chronic obstructive pulmonary disease congenital leptin deficiency hepatocellular carcinoma hypertension osteoporosis rhinitis type 2 diabetes mellitus	DOID:0050741 DOID:0111334 DOID:10763 DOID:11394 DOID:11476 DOID:14018 DOID:3083 DOID:4483 DOID:684 DOID:9352	DNA binding T cell activation T cell differentiation activation of protein kinase C activity activation of protein kinase activity adipose tissue development adult behavior adult feeding behavior alcohol biosynthetic process alcohol metabolic process alditol biosynthetic process alditol metabolic process amide transport anatomical structure development anatomical structure formation involved in morphogenesis angiogenesis animal organ development aorta development artery development behavior bile acid metabolic process binding biological regulation biological_process biomineral tissue development biosynthetic process blood vessel development blood vessel diameter maintenance bone growth bone mineralization involved in bone maturation bone mineralization carbohydrate biosynthetic process carbohydrate derivative metabolic process carbohydrate homeostasis carbohydrate metabolic process carboxylic acid catabolic process carboxylic acid metabolic process carboxylic acid transport cardiac muscle hypertrophy catabolic process cell activation cell adhesion cell communication cell development cell differentiation cell surface receptor signaling pathway cell-cell adhesion cellular anatomical entity cellular catabolic process cellular developmental process cellular lipid catabolic process cellular lipid metabolic process cellular localization cellular macromolecule localization cellular metabolic process cellular process cellular response to L-ascorbic acid cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular response to endogenous stimulus cellular response to external stimulus cellular response to extracellular stimulus cellular response to hormone stimulus cellular response to insulin stimulus cellular response to leptin stimulus cellular response to lipid cellular response to monosaccharide stimulus cellular response to nitrogen compound cellular response to nutrient levels cellular response to nutrient cellular response to organic cyclic compound cellular response to organic substance cellular response to organonitrogen compound cellular response to oxygen-containing compound cellular response to peptide hormone stimulus cellular response to peptide cellular response to retinoic acid cellular response to salt cellular response to stimulus cellular response to vitamin cellular_component central nervous system neuron development chemical homeostasis cholesterol metabolic process circadian rhythm circulatory system process connective tissue development cytokine-mediated signaling pathway cytosol determination of adult lifespan developmental growth developmental process digestive system process eating behavior elastin metabolic process endocytosis energy derivation by oxidation of organic compounds energy homeostasis energy reserve metabolic process establishment of localization establishment of protein localization to extracellular region establishment of protein localization export from cell extracellular region extracellular space fatty acid beta-oxidation fatty acid catabolic process fatty acid metabolic process fatty acid oxidation fatty acid transport feeding behavior female pregnancy generation of precursor metabolites and energy glucose homeostasis glucose metabolic process glycerol biosynthetic process glycerol metabolic process glycoprotein metabolic process growth hexose metabolic process homeostatic process hormone activity hormone metabolic process hormone receptor binding hormone secretion hormone transport icosanoid secretion icosanoid transport immune system process import into cell insulin secretion intestinal absorption intracellular signal transduction leptin receptor binding leptin-mediated signaling pathway leukocyte activation leukocyte adhesion to vascular endothelial cell leukocyte cell-cell adhesion leukocyte differentiation leukocyte tethering or rolling lipid catabolic process lipid export from cell lipid metabolic process lipid modification lipid oxidation lipid transport localization lymphocyte activation lymphocyte differentiation macromolecule localization macromolecule metabolic process metabolic process molecular function activator activity molecular function regulator activity molecular_function monocarboxylic acid catabolic process monocarboxylic acid metabolic process monocarboxylic acid transport mononuclear cell differentiation monosaccharide metabolic process multi-multicellular organism process multi-organism reproductive process multicellular organismal process multicellular organismal reproductive process multicellular organismal-level homeostasis muscle hypertrophy muscle system process negative regulation of DNA-templated transcription negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of amine transport negative regulation of amino acid transport negative regulation of apoptotic process negative regulation of appetite by leptin-mediated signaling pathway negative regulation of appetite negative regulation of autophagy negative regulation of biological process negative regulation of biosynthetic process negative regulation of cartilage development negative regulation of catabolic process negative regulation of cell communication negative regulation of cellular biosynthetic process negative regulation of cellular catabolic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of developmental process negative regulation of glucagon secretion negative regulation of glucose import negative regulation of glucose transmembrane transport negative regulation of glutamine transport negative regulation of hormone secretion negative regulation of lipid localization negative regulation of lipid storage negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of organic acid transport negative regulation of peptide hormone secretion negative regulation of peptide secretion negative regulation of programmed cell death negative regulation of response to external stimulus negative regulation of response to extracellular stimulus negative regulation of response to food negative regulation of response to nutrient levels negative regulation of response to stimulus negative regulation of secretion by cell negative regulation of secretion negative regulation of signaling negative regulation of transcription by RNA polymerase II negative regulation of transmembrane transport negative regulation of transport negative regulation of vasoconstriction neuron development nitrogen compound metabolic process nitrogen compound transport nucleic acid binding organ growth organic acid catabolic process organic acid metabolic process organic acid transport organic anion transport organic cyclic compound binding organic cyclic compound metabolic process organic hydroxy compound biosynthetic process organic hydroxy compound metabolic process organic substance biosynthetic process organic substance catabolic process organic substance metabolic process organic substance transport organonitrogen compound metabolic process ovulation cycle process ovulation from ovarian follicle ovulation oxoacid metabolic process peptide hormone receptor binding peptide hormone secretion peptide secretion peptide transport phagocytosis placenta development polyol biosynthetic process polyol metabolic process positive regulation of MAPK cascade positive regulation of T cell activation positive regulation of T cell proliferation positive regulation of TOR signaling positive regulation of apoptotic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of catalytic activity positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell communication positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cellular response to insulin stimulus positive regulation of cold-induced thermogenesis positive regulation of cytokine production positive regulation of developmental growth positive regulation of developmental process positive regulation of establishment of protein localization positive regulation of fat cell apoptotic process positive regulation of follicle-stimulating hormone secretion positive regulation of gene expression positive regulation of gonadotropin secretion positive regulation of growth positive regulation of hepatic stellate cell activation positive regulation of hormone secretion positive regulation of immune system process positive regulation of insulin receptor signaling pathway positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of intracellular protein transport positive regulation of intracellular signal transduction positive regulation of intracellular transport positive regulation of kinase activity positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of luteinizing hormone secretion positive regulation of lymphocyte activation positive regulation of lymphocyte proliferation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of monoatomic ion transport positive regulation of mononuclear cell proliferation positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of nucleocytoplasmic transport positive regulation of p38MAPK cascade positive regulation of peroxisome proliferator activated receptor signaling pathway positive regulation of phosphate metabolic process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of programmed cell death positive regulation of protein import into nucleus positive regulation of protein kinase activity positive regulation of protein localization to nucleus positive regulation of protein localization positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of protein transport positive regulation of reactive oxygen species metabolic process positive regulation of receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via STAT positive regulation of response to stimulus positive regulation of secretion by cell positive regulation of secretion positive regulation of signal transduction positive regulation of signaling positive regulation of stress-activated MAPK cascade positive regulation of stress-activated protein kinase signaling cascade positive regulation of transferase activity positive regulation of transport positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production primary metabolic process prostaglandin secretion prostaglandin transport protein binding protein localization to extracellular region protein localization protein metabolic process protein secretion protein transport receptor ligand activity receptor signaling pathway via JAK-STAT receptor signaling pathway via STAT regulation of DNA-templated transcription regulation of MAPK cascade regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of T cell activation regulation of T cell proliferation regulation of TOR signaling regulation of amine transport regulation of amino acid transport regulation of anatomical structure morphogenesis regulation of anatomical structure size regulation of angiogenesis regulation of apoptotic process regulation of appetite regulation of autophagy regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of blood circulation regulation of blood pressure regulation of bone remodeling regulation of brown fat cell differentiation regulation of carbohydrate biosynthetic process regulation of carbohydrate metabolic process regulation of cartilage development regulation of catabolic process regulation of catalytic activity regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell cycle regulation of cell differentiation regulation of cell killing regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular catabolic process regulation of cellular localization regulation of cellular metabolic process regulation of cellular process regulation of cellular response to insulin stimulus regulation of cellular response to stress regulation of cholesterol transport regulation of cold-induced thermogenesis regulation of cytokine production involved in inflammatory response regulation of cytokine production regulation of defense response regulation of developmental growth regulation of developmental process regulation of digestive system process regulation of endocrine process regulation of endothelial cell proliferation regulation of epithelial cell proliferation regulation of establishment of protein localization regulation of fat cell apoptotic process regulation of fat cell differentiation regulation of follicle-stimulating hormone secretion regulation of gene expression regulation of glucagon secretion regulation of gluconeogenesis regulation of glucose import regulation of glucose metabolic process regulation of glucose transmembrane transport regulation of glutamine transport regulation of gonadotropin secretion regulation of growth regulation of hepatic stellate cell activation regulation of hormone levels regulation of hormone secretion regulation of immune effector process regulation of immune response regulation of immune system process regulation of innate immune response regulation of insulin receptor signaling pathway regulation of insulin secretion regulation of interleukin-12 production regulation of interleukin-6 production regulation of interleukin-8 production regulation of intestinal absorption regulation of intestinal cholesterol absorption regulation of intestinal lipid absorption regulation of intracellular protein transport regulation of intracellular signal transduction regulation of intracellular transport regulation of kinase activity regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of leukocyte mediated cytotoxicity regulation of leukocyte mediated immunity regulation of leukocyte proliferation regulation of lipid biosynthetic process regulation of lipid localization regulation of lipid metabolic process regulation of lipid storage regulation of lipid transport regulation of lipoprotein lipid oxidation regulation of lipoprotein metabolic process regulation of lipoprotein oxidation regulation of localization regulation of luteinizing hormone secretion regulation of lymphocyte activation regulation of lymphocyte mediated immunity regulation of lymphocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of monoatomic ion transport regulation of mononuclear cell proliferation regulation of monooxygenase activity regulation of multicellular organismal development regulation of multicellular organismal process regulation of natural killer cell activation regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell mediated immunity regulation of natural killer cell proliferation regulation of nitric-oxide synthase activity regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of nucleocytoplasmic transport regulation of organic acid transport regulation of oxidoreductase activity regulation of p38MAPK cascade regulation of peptide hormone secretion regulation of peptide secretion regulation of peptide transport regulation of peroxisome proliferator activated receptor signaling pathway regulation of phosphate metabolic process regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of phosphorus metabolic process regulation of phosphorylation regulation of primary metabolic process regulation of programmed cell death regulation of protein import into nucleus regulation of protein kinase activity regulation of protein localization to nucleus regulation of protein localization regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of protein secretion regulation of protein transport regulation of reactive oxygen species metabolic process regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT regulation of response to biotic stimulus regulation of response to external stimulus regulation of response to extracellular stimulus regulation of response to food regulation of response to nutrient levels regulation of response to stimulus regulation of response to stress regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling regulation of small molecule metabolic process regulation of steroid biosynthetic process regulation of steroid metabolic process regulation of sterol transport regulation of stress-activated MAPK cascade regulation of stress-activated protein kinase signaling cascade regulation of system process regulation of tissue remodeling regulation of transcription by RNA polymerase II regulation of transferase activity regulation of transmembrane transport regulation of transport regulation of tube diameter regulation of tube size regulation of tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of vasculature development regulation of vasoconstriction reproduction reproductive process response to L-ascorbic acid response to abiotic stimulus response to activity response to alcohol response to carbohydrate response to chemical response to decreased oxygen levels response to dietary excess response to endogenous stimulus response to estradiol response to ethanol response to external stimulus response to extracellular stimulus response to hormone response to hypoxia response to insulin response to leptin response to lipid response to monosaccharide response to nitrogen compound response to nutrient levels response to nutrient response to organic cyclic compound response to organic substance response to organonitrogen compound response to oxygen levels response to oxygen-containing compound response to peptide hormone response to peptide response to retinoic acid response to salt response to stimulus response to stress response to vitamin E response to vitamin rhythmic process secondary alcohol metabolic process secretion by cell secretion sexual reproduction signal release signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity small molecule biosynthetic process small molecule catabolic process small molecule metabolic process steroid metabolic process sterol metabolic process striated muscle hypertrophy system process tissue development transport vascular process in circulatory system vesicle-mediated transport	GO:0000003 GO:0000122 GO:0001525 GO:0001542 GO:0001568 GO:0001666 GO:0001775 GO:0001817 GO:0001819 GO:0001890 GO:0001910 GO:0001932 GO:0001934 GO:0001936 GO:0002021 GO:0002376 GO:0002521 GO:0002682 GO:0002684 GO:0002694 GO:0002696 GO:0002697 GO:0002703 GO:0002706 GO:0002715 GO:0002790 GO:0002791 GO:0002792 GO:0002831 GO:0003008 GO:0003012 GO:0003013 GO:0003018 GO:0003300 GO:0003674 GO:0003676 GO:0003677 GO:0005102 GO:0005179 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0005829 GO:0005975 GO:0005996 GO:0006006 GO:0006066 GO:0006071 GO:0006082 GO:0006091 GO:0006109 GO:0006111 GO:0006112 GO:0006114 GO:0006355 GO:0006357 GO:0006629 GO:0006631 GO:0006635 GO:0006807 GO:0006810 GO:0006869 GO:0006897 GO:0006909 GO:0006950 GO:0007154 GO:0007155 GO:0007159 GO:0007165 GO:0007166 GO:0007259 GO:0007565 GO:0007584 GO:0007610 GO:0007623 GO:0007631 GO:0008104 GO:0008150 GO:0008152 GO:0008202 GO:0008203 GO:0008206 GO:0008217 GO:0008284 GO:0008340 GO:0008343 GO:0009056 GO:0009058 GO:0009062 GO:0009100 GO:0009306 GO:0009605 GO:0009628 GO:0009719 GO:0009725 GO:0009743 GO:0009888 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009894 GO:0009895 GO:0009914 GO:0009966 GO:0009967 GO:0009987 GO:0009991 GO:0010033 GO:0010243 GO:0010468 GO:0010506 GO:0010507 GO:0010556 GO:0010557 GO:0010558 GO:0010562 GO:0010604 GO:0010605 GO:0010628 GO:0010646 GO:0010647 GO:0010648 GO:0010817 GO:0010827 GO:0010829 GO:0010883 GO:0010888 GO:0010906 GO:0014070 GO:0014823 GO:0014896 GO:0014897 GO:0015031 GO:0015711 GO:0015718 GO:0015732 GO:0015833 GO:0015849 GO:0015908 GO:0015980 GO:0016042 GO:0016051 GO:0016054 GO:0016125 GO:0016192 GO:0019216 GO:0019218 GO:0019219 GO:0019220 GO:0019221 GO:0019222 GO:0019229 GO:0019318 GO:0019395 GO:0019400 GO:0019401 GO:0019538 GO:0019751 GO:0019752 GO:0019953 GO:0021954 GO:0022407 GO:0022409 GO:0022414 GO:0022600 GO:0022602 GO:0022603 GO:0023051 GO:0023056 GO:0023057 GO:0023061 GO:0030072 GO:0030073 GO:0030098 GO:0030154 GO:0030155 GO:0030217 GO:0030258 GO:0030282 GO:0030300 GO:0030534 GO:0030545 GO:0030546 GO:0030728 GO:0031214 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031329 GO:0031330 GO:0031341 GO:0031347 GO:0031399 GO:0031401 GO:0031667 GO:0031668 GO:0031669 GO:0031670 GO:0032006 GO:0032008 GO:0032095 GO:0032096 GO:0032098 GO:0032099 GO:0032101 GO:0032102 GO:0032104 GO:0032105 GO:0032107 GO:0032108 GO:0032147 GO:0032276 GO:0032278 GO:0032309 GO:0032310 GO:0032355 GO:0032368 GO:0032371 GO:0032374 GO:0032386 GO:0032388 GO:0032501 GO:0032502 GO:0032526 GO:0032655 GO:0032675 GO:0032677 GO:0032680 GO:0032735 GO:0032755 GO:0032757 GO:0032760 GO:0032768 GO:0032787 GO:0032814 GO:0032817 GO:0032868 GO:0032869 GO:0032870 GO:0032872 GO:0032874 GO:0032879 GO:0032880 GO:0032890 GO:0032891 GO:0032940 GO:0032944 GO:0032946 GO:0033036 GO:0033157 GO:0033197 GO:0033210 GO:0033273 GO:0033500 GO:0033591 GO:0033674 GO:0033684 GO:0033686 GO:0033993 GO:0034103 GO:0034284 GO:0034440 GO:0034442 GO:0034762 GO:0034763 GO:0035150 GO:0035265 GO:0035296 GO:0035358 GO:0035360 GO:0035556 GO:0035592 GO:0035630 GO:0035904 GO:0036293 GO:0038108 GO:0040007 GO:0040008 GO:0042102 GO:0042110 GO:0042127 GO:0042129 GO:0042221 GO:0042269 GO:0042306 GO:0042307 GO:0042325 GO:0042327 GO:0042445 GO:0042592 GO:0042593 GO:0042755 GO:0042886 GO:0042981 GO:0043065 GO:0043066 GO:0043067 GO:0043068 GO:0043069 GO:0043085 GO:0043170 GO:0043255 GO:0043269 GO:0043270 GO:0043408 GO:0043410 GO:0043434 GO:0043436 GO:0043549 GO:0044057 GO:0044058 GO:0044060 GO:0044093 GO:0044237 GO:0044238 GO:0044242 GO:0044248 GO:0044255 GO:0044281 GO:0044282 GO:0044283 GO:0044320 GO:0044321 GO:0044703 GO:0044706 GO:0045088 GO:0045184 GO:0045321 GO:0045471 GO:0045595 GO:0045598 GO:0045765 GO:0045785 GO:0045859 GO:0045860 GO:0045892 GO:0045906 GO:0045927 GO:0045934 GO:0045937 GO:0046165 GO:0046173 GO:0046324 GO:0046325 GO:0046395 GO:0046425 GO:0046427 GO:0046626 GO:0046628 GO:0046649 GO:0046822 GO:0046824 GO:0046850 GO:0046879 GO:0046880 GO:0046881 GO:0046883 GO:0046887 GO:0046888 GO:0046890 GO:0046903 GO:0046942 GO:0048018 GO:0048468 GO:0048511 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048589 GO:0048609 GO:0048638 GO:0048639 GO:0048646 GO:0048666 GO:0048856 GO:0048869 GO:0048871 GO:0048878 GO:0050670 GO:0050671 GO:0050678 GO:0050708 GO:0050746 GO:0050776 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050796 GO:0050810 GO:0050863 GO:0050865 GO:0050867 GO:0050870 GO:0050892 GO:0050896 GO:0050901 GO:0050999 GO:0051046 GO:0051047 GO:0051048 GO:0051049 GO:0051050 GO:0051051 GO:0051093 GO:0051094 GO:0051171 GO:0051172 GO:0051173 GO:0051174 GO:0051179 GO:0051222 GO:0051223 GO:0051234 GO:0051239 GO:0051240 GO:0051241 GO:0051246 GO:0051247 GO:0051249 GO:0051251 GO:0051252 GO:0051253 GO:0051338 GO:0051341 GO:0051347 GO:0051427 GO:0051428 GO:0051541 GO:0051641 GO:0051716 GO:0051726 GO:0051896 GO:0051897 GO:0051952 GO:0051953 GO:0051955 GO:0051956 GO:0060255 GO:0060341 GO:0060587 GO:0060612 GO:0060840 GO:0061035 GO:0061037 GO:0061448 GO:0061756 GO:0062012 GO:0065007 GO:0065008 GO:0065009 GO:0070092 GO:0070093 GO:0070201 GO:0070302 GO:0070304 GO:0070482 GO:0070663 GO:0070665 GO:0070727 GO:0070887 GO:0071295 GO:0071298 GO:0071300 GO:0071310 GO:0071322 GO:0071326 GO:0071375 GO:0071396 GO:0071407 GO:0071417 GO:0071495 GO:0071496 GO:0071692 GO:0071702 GO:0071704 GO:0071705 GO:0071715 GO:0072329 GO:0080090 GO:0080134 GO:0080135 GO:0090066 GO:0090087 GO:0090276 GO:0090278 GO:0090316 GO:0090335 GO:0097009 GO:0097159 GO:0097305 GO:0097696 GO:0097746 GO:0098609 GO:0098657 GO:0098772 GO:0098868 GO:0110165 GO:0120161 GO:0120162 GO:0140352 GO:0140353 GO:0140677 GO:1900015 GO:1900076 GO:1900078 GO:1900180 GO:1900182 GO:1900744 GO:1900745 GO:1901135 GO:1901342 GO:1901360 GO:1901564 GO:1901575 GO:1901576 GO:1901615 GO:1901617 GO:1901652 GO:1901653 GO:1901698 GO:1901699 GO:1901700 GO:1901701 GO:1902074 GO:1902075 GO:1902531 GO:1902533 GO:1902652 GO:1902679 GO:1903037 GO:1903039 GO:1903131 GO:1903522 GO:1903530 GO:1903531 GO:1903532 GO:1903555 GO:1903557 GO:1903829 GO:1904478 GO:1904649 GO:1904651 GO:1904729 GO:1904892 GO:1904894 GO:1904951 GO:1905952 GO:1905953 GO:1990051 GO:1990460 GO:2000026 GO:2000377 GO:2000379 GO:2000485 GO:2000486 GO:2000489 GO:2000491 GO:2001141
3073	hexosaminidase subunit alpha	HEXA Aliases: GM2 gangliosidosis Tay Sachs disease beta-hexosaminidase subunit alpha	Homo sapiens (human)	9606	Tay-Sachs disease	DOID:3320	N-acetyl-beta-D-galactosaminidase activity N-glycan processing UDP-glycosyltransferase activity acetylglucosaminyltransferase activity adult behavior adult locomotory behavior adult walking behavior amide metabolic process amino disaccharide catabolic process amino disaccharide metabolic process aminoglycan biosynthetic process aminoglycan catabolic process aminoglycan metabolic process anatomical structure development anatomical structure morphogenesis axon ensheathment azurophil granule behavior beta-N-acetylglucosaminidase activity beta-N-acetylhexosaminidase activity beta-N-acetylhexosaminidase complex binding biological_process biosynthetic process carbohydrate catabolic process carbohydrate derivative biosynthetic process carbohydrate derivative catabolic process carbohydrate derivative metabolic process carbohydrate metabolic process carboxylic acid catabolic process carboxylic acid metabolic process catabolic process catalytic activity catalytic complex cell morphogenesis involved in neuron differentiation cell morphogenesis cellular anatomical entity cellular biosynthetic process cellular catabolic process cellular component organization or biogenesis cellular component organization cellular lipid catabolic process cellular lipid metabolic process cellular metabolic process cellular process cellular_component ceramide catabolic process ceramide metabolic process cytoplasmic vesicle cytosol dermatan sulfate catabolic process dermatan sulfate metabolic process developmental process ensheathment of neurons extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle ganglioside catabolic process ganglioside metabolic process glycolipid catabolic process glycolipid metabolic process glycoprotein metabolic process glycosaminoglycan biosynthetic process glycosaminoglycan catabolic process glycosaminoglycan metabolic process glycosphingolipid catabolic process glycosphingolipid metabolic process glycosyltransferase activity hexosaminidase activity hexosyltransferase activity hyaluronan catabolic process hyaluronan metabolic process hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle intracellular vesicle lipid catabolic process lipid metabolic process lipid storage liposaccharide metabolic process localization locomotory behavior lysosomal lumen lysosome organization lysosome lytic vacuole organization lytic vacuole macromolecule biosynthetic process macromolecule catabolic process macromolecule metabolic process maintenance of location in cell maintenance of location membrane lipid catabolic process membrane lipid metabolic process membrane-bounded organelle membrane-enclosed lumen membrane metabolic process molecular_function monocarboxylic acid catabolic process monocarboxylic acid metabolic process monosaccharide catabolic process monosaccharide metabolic process mucopolysaccharide metabolic process multicellular organismal process myelination nervous system process neuromuscular process controlling balance neuromuscular process controlling posture neuromuscular process nitrogen compound metabolic process organelle lumen organelle organization organelle organic acid catabolic process organic acid metabolic process organic substance biosynthetic process organic substance catabolic process organic substance metabolic process organonitrogen compound biosynthetic process organonitrogen compound catabolic process organonitrogen compound metabolic process oxoacid metabolic process primary lysosome primary metabolic process protein binding protein dimerization activity protein heterodimerization activity protein metabolic process protein-containing complex reproduction secretory granule secretory vesicle sensory perception of mechanical stimulus sensory perception of sound sensory perception sexual reproduction skeletal system development small molecule catabolic process small molecule metabolic process sphingolipid catabolic process sphingolipid metabolic process sulfur compound catabolic process sulfur compound metabolic process system development system process transferase activity vacuolar lumen vacuole organization vacuole vesicle walking behavior	GO:0000003 GO:0000323 GO:0000902 GO:0001501 GO:0001573 GO:0003008 GO:0003674 GO:0003824 GO:0004553 GO:0004563 GO:0005488 GO:0005515 GO:0005575 GO:0005764 GO:0005766 GO:0005773 GO:0005775 GO:0005829 GO:0005975 GO:0005996 GO:0006022 GO:0006023 GO:0006024 GO:0006026 GO:0006027 GO:0006082 GO:0006491 GO:0006629 GO:0006643 GO:0006664 GO:0006665 GO:0006672 GO:0006687 GO:0006689 GO:0006790 GO:0006807 GO:0006996 GO:0007033 GO:0007040 GO:0007272 GO:0007600 GO:0007605 GO:0007610 GO:0007626 GO:0007628 GO:0008150 GO:0008152 GO:0008194 GO:0008344 GO:0008366 GO:0008375 GO:0009056 GO:0009057 GO:0009058 GO:0009059 GO:0009100 GO:0009653 GO:0009987 GO:0015929 GO:0016020 GO:0016042 GO:0016043 GO:0016052 GO:0016054 GO:0016231 GO:0016740 GO:0016757 GO:0016758 GO:0016787 GO:0016798 GO:0019377 GO:0019538 GO:0019752 GO:0019915 GO:0019953 GO:0030141 GO:0030149 GO:0030203 GO:0030205 GO:0030209 GO:0030212 GO:0030214 GO:0030534 GO:0031410 GO:0031974 GO:0031982 GO:0032501 GO:0032502 GO:0032787 GO:0032991 GO:0042552 GO:0042582 GO:0043170 GO:0043202 GO:0043226 GO:0043227 GO:0043229 GO:0043230 GO:0043231 GO:0043233 GO:0043436 GO:0043603 GO:0044237 GO:0044238 GO:0044242 GO:0044248 GO:0044249 GO:0044255 GO:0044273 GO:0044281 GO:0044282 GO:0046365 GO:0046395 GO:0046466 GO:0046479 GO:0046514 GO:0046982 GO:0046983 GO:0048667 GO:0048731 GO:0048856 GO:0050877 GO:0050884 GO:0050885 GO:0050905 GO:0050954 GO:0051179 GO:0051235 GO:0051651 GO:0052779 GO:0052782 GO:0065010 GO:0070013 GO:0070062 GO:0071704 GO:0071840 GO:0072329 GO:0080171 GO:0090659 GO:0097708 GO:0099503 GO:0102148 GO:0110165 GO:1901135 GO:1901136 GO:1901137 GO:1901564 GO:1901565 GO:1901566 GO:1901575 GO:1901576 GO:1902494 GO:1903509 GO:1903510 GO:1903561 GO:1905379
3953	leptin receptor	LEPR	Homo sapiens (human)	9606	chronic obstructive pulmonary disease coronary artery disease dilated cardiomyopathy hepatocellular carcinoma hypertension metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease obesity obstructive sleep apnea osteoporosis type 2 diabetes mellitus	DOID:0050848 DOID:0080208 DOID:0080547 DOID:10763 DOID:11476 DOID:12930 DOID:3083 DOID:3393 DOID:684 DOID:9352 DOID:9970	T cell activation T cell differentiation alcohol metabolic process amide binding anatomical structure development anatomical structure formation involved in morphogenesis angiogenesis basolateral plasma membrane binding biological regulation biological_process biosynthetic process bone growth carbohydrate biosynthetic process carbohydrate homeostasis carbohydrate metabolic process cell activation cell differentiation cell population proliferation cell surface receptor signaling pathway cellular anatomical entity cellular developmental process cellular metabolic process cellular process cellular_component chemical homeostasis cholesterol metabolic process circulatory system process cytokine binding cytokine receptor activity cytokine-mediated signaling pathway developmental growth developmental process endocytosis energy derivation by oxidation of organic compounds energy homeostasis energy reserve metabolic process establishment of localization external side of plasma membrane extracellular region generation of precursor metabolites and energy glial cell proliferation glucan metabolic process gluconeogenesis glucose homeostasis glucose metabolic process glycogen metabolic process growth hexose biosynthetic process hexose metabolic process homeostatic process hormone binding identical protein binding immune receptor activity immune system process import into cell leptin receptor activity leptin-mediated signaling pathway leukocyte activation leukocyte differentiation lipid metabolic process localization lymphocyte activation lymphocyte differentiation macromolecule metabolic process membrane metabolic process molecular transducer activity molecular_function mononuclear cell differentiation monosaccharide biosynthetic process monosaccharide metabolic process multicellular organism development multicellular organismal process multicellular organismal-level homeostasis negative regulation of autophagy negative regulation of biological process negative regulation of biosynthetic process negative regulation of carbohydrate metabolic process negative regulation of catabolic process negative regulation of cellular biosynthetic process negative regulation of cellular catabolic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of gluconeogenesis negative regulation of metabolic process negative regulation of small molecule metabolic process organ growth organic cyclic compound metabolic process organic hydroxy compound metabolic process organic substance biosynthetic process organic substance metabolic process peptide binding peptide hormone binding phagocytosis plasma membrane region polysaccharide metabolic process positive regulation of biological process positive regulation of cell population proliferation positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cold-induced thermogenesis positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation primary metabolic process protein binding protein-containing complex receptor complex receptor signaling pathway via STAT regulation of autophagy regulation of behavior regulation of biological process regulation of biosynthetic process regulation of bone remodeling regulation of carbohydrate biosynthetic process regulation of carbohydrate metabolic process regulation of catabolic process regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular catabolic process regulation of cellular metabolic process regulation of cellular process regulation of cold-induced thermogenesis regulation of feeding behavior regulation of gluconeogenesis regulation of glucose metabolic process regulation of localization regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of primary metabolic process regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of small molecule metabolic process regulation of tissue remodeling regulation of transport reproduction response to chemical response to endogenous stimulus response to hormone response to leptin response to organic substance response to stimulus secondary alcohol metabolic process sexual reproduction side of membrane signal transduction signaling receptor activity small molecule biosynthetic process small molecule metabolic process steroid metabolic process sterol metabolic process system process transmembrane signaling receptor activity transport across blood-brain barrier transport vascular process in circulatory system vascular transport vesicle-mediated transport	GO:0000003 GO:0001525 GO:0001775 GO:0001932 GO:0001934 GO:0002376 GO:0002521 GO:0003008 GO:0003013 GO:0003018 GO:0003674 GO:0004888 GO:0004896 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005975 GO:0005976 GO:0005977 GO:0005996 GO:0006006 GO:0006066 GO:0006091 GO:0006094 GO:0006109 GO:0006111 GO:0006112 GO:0006629 GO:0006810 GO:0006897 GO:0006909 GO:0007165 GO:0007166 GO:0007275 GO:0008150 GO:0008152 GO:0008202 GO:0008203 GO:0008283 GO:0008284 GO:0009058 GO:0009719 GO:0009725 GO:0009889 GO:0009890 GO:0009892 GO:0009893 GO:0009894 GO:0009895 GO:0009897 GO:0009987 GO:0010033 GO:0010232 GO:0010506 GO:0010507 GO:0010562 GO:0010604 GO:0010906 GO:0014009 GO:0015980 GO:0016020 GO:0016051 GO:0016125 GO:0016192 GO:0016323 GO:0017046 GO:0019220 GO:0019221 GO:0019222 GO:0019318 GO:0019319 GO:0019953 GO:0019955 GO:0030098 GO:0030154 GO:0030217 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031329 GO:0031330 GO:0031399 GO:0031401 GO:0032501 GO:0032502 GO:0032879 GO:0032991 GO:0033210 GO:0033218 GO:0033500 GO:0034103 GO:0035265 GO:0038021 GO:0038023 GO:0040007 GO:0042110 GO:0042127 GO:0042221 GO:0042277 GO:0042325 GO:0042327 GO:0042562 GO:0042592 GO:0042593 GO:0042802 GO:0043170 GO:0043235 GO:0043255 GO:0044042 GO:0044237 GO:0044238 GO:0044281 GO:0044283 GO:0044321 GO:0045321 GO:0045721 GO:0045912 GO:0045937 GO:0046364 GO:0046649 GO:0046850 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048589 GO:0048646 GO:0048856 GO:0048869 GO:0048871 GO:0048878 GO:0050789 GO:0050794 GO:0050795 GO:0050896 GO:0051049 GO:0051171 GO:0051173 GO:0051174 GO:0051179 GO:0051234 GO:0051239 GO:0051240 GO:0051246 GO:0051247 GO:0060089 GO:0060255 GO:0060259 GO:0062012 GO:0062014 GO:0065007 GO:0071704 GO:0080090 GO:0097009 GO:0097696 GO:0098552 GO:0098590 GO:0098657 GO:0098868 GO:0110165 GO:0120161 GO:0120162 GO:0140375 GO:0150104 GO:1901360 GO:1901576 GO:1901615 GO:1902652 GO:1903131
7425	VGF nerve growth factor inducible	VGF	Homo sapiens (human)	9606			Golgi apparatus amide transport anatomical structure development binding biological process involved in interspecies interaction between organisms biological regulation biological_process carbohydrate homeostasis cell body cell communication cell junction cell-cell signaling cellular anatomical entity cellular localization cellular macromolecule localization cellular metabolic process cellular process cellular_component chemical homeostasis cytoplasmic vesicle defense response to bacterium defense response to other organism defense response developmental process involved in reproduction developmental process endoplasmic reticulum lumen energy homeostasis establishment of localization establishment of protein localization to extracellular region establishment of protein localization export from cell extracellular space generation of precursor metabolites and energy glucose homeostasis glutamatergic synapse growth factor activity homeostatic process hormone activity hormone secretion hormone transport insulin secretion intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle intracellular vesicle localization macromolecule localization membrane-bounded organelle membrane-enclosed lumen metabolic process modulation of chemical synaptic transmission molecular function activator activity molecular function regulator activity molecular_function multicellular organismal process multicellular organismal-level homeostasis neuronal cell body neuropeptide activity neuropeptide hormone activity nitrogen compound transport organelle lumen organelle organic substance transport ovarian follicle development peptide hormone secretion peptide secretion peptide transport protein binding protein localization to extracellular region protein localization protein secretion protein transport receptor ligand activity regulation of biological process regulation of biological quality regulation of cell communication regulation of cellular process regulation of hormone levels regulation of neuronal synaptic plasticity regulation of signaling regulation of synaptic plasticity regulation of trans-synaptic signaling reproduction reproductive process response to abiotic stimulus response to bacterium response to biotic stimulus response to cAMP response to chemical response to cold response to dietary excess response to endogenous stimulus response to external biotic stimulus response to external stimulus response to extracellular stimulus response to hormone response to insulin response to nitrogen compound response to nutrient levels response to organic cyclic compound response to organic substance response to organonitrogen compound response to organophosphorus response to other organism response to oxygen-containing compound response to peptide hormone response to peptide response to purine-containing compound response to stimulus response to stress response to temperature stimulus secretion by cell secretion sexual reproduction signal release signal transduction signaling receptor activator activity signaling receptor binding signaling receptor regulator activity signaling synapse synaptic signaling via neuropeptide synaptic signaling transport vesicle transport vesicle	GO:0000003 GO:0001541 GO:0002021 GO:0002790 GO:0003006 GO:0003674 GO:0005102 GO:0005179 GO:0005184 GO:0005488 GO:0005515 GO:0005575 GO:0005615 GO:0005788 GO:0005794 GO:0006091 GO:0006810 GO:0006950 GO:0006952 GO:0007154 GO:0007165 GO:0007267 GO:0008083 GO:0008104 GO:0008150 GO:0008152 GO:0009266 GO:0009306 GO:0009409 GO:0009605 GO:0009607 GO:0009617 GO:0009628 GO:0009719 GO:0009725 GO:0009914 GO:0009987 GO:0009991 GO:0010033 GO:0010243 GO:0010646 GO:0010817 GO:0014070 GO:0014074 GO:0015031 GO:0015833 GO:0019953 GO:0022414 GO:0023051 GO:0023052 GO:0023061 GO:0030054 GO:0030072 GO:0030073 GO:0030133 GO:0030545 GO:0030546 GO:0031410 GO:0031667 GO:0031974 GO:0031982 GO:0032501 GO:0032502 GO:0032868 GO:0032940 GO:0033036 GO:0033500 GO:0035592 GO:0042221 GO:0042592 GO:0042593 GO:0042742 GO:0042886 GO:0043025 GO:0043207 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0043434 GO:0044237 GO:0044297 GO:0044419 GO:0045184 GO:0045202 GO:0046683 GO:0046879 GO:0046903 GO:0048018 GO:0048167 GO:0048168 GO:0048856 GO:0048871 GO:0048878 GO:0050789 GO:0050794 GO:0050804 GO:0050896 GO:0051179 GO:0051234 GO:0051591 GO:0051641 GO:0051707 GO:0065007 GO:0065008 GO:0070013 GO:0070727 GO:0071692 GO:0071702 GO:0071705 GO:0097009 GO:0097708 GO:0098542 GO:0098772 GO:0098978 GO:0099177 GO:0099536 GO:0099538 GO:0110165 GO:0140352 GO:0140677 GO:0160041 GO:1901652 GO:1901698 GO:1901700
3593	interleukin 12B	IL12B	Homo sapiens (human)	9606	asthma chronic obstructive pulmonary disease immunodeficiency 29 salmonellosis	DOID:0060859 DOID:0111950 DOID:2841 DOID:3083	CD4-positive, alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation involved in immune response CD4-positive, alpha-beta T cell differentiation T cell activation involved in immune response T cell activation T cell differentiation involved in immune response T cell differentiation T cell proliferation T-helper 1 type immune response T-helper cell differentiation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains adaptive immune response alpha-beta T cell activation involved in immune response alpha-beta T cell activation alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation binding biological process involved in interspecies interaction between organisms biological regulation biological_process cell activation involved in immune response cell activation cell differentiation cell migration cell motility cell population proliferation cell surface receptor signaling pathway cell surface cellular anatomical entity cellular developmental process cellular process cellular response to biotic stimulus cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to lipid cellular response to lipopolysaccharide cellular response to molecule of bacterial origin cellular response to organic substance cellular response to oxygen-containing compound cellular response to stimulus cellular response to type II interferon cellular_component cytokine activity cytokine binding cytokine receptor activity cytokine receptor binding cytokine-mediated signaling pathway cytosol defense response to Gram-negative bacterium defense response to bacterium defense response to other organism defense response to protozoan defense response to symbiont defense response to virus defense response developmental process endoplasmic reticulum lumen endosome lumen external side of plasma membrane extracellular region extracellular space growth factor activity growth factor receptor binding identical protein binding immune effector process immune receptor activity immune response immune system process interleukin-12 alpha subunit binding interleukin-12 binding interleukin-12 complex interleukin-12 receptor binding interleukin-12-mediated signaling pathway interleukin-23 complex interleukin-23 receptor binding intracellular organelle lumen late endosome lumen leukocyte activation involved in immune response leukocyte activation leukocyte differentiation leukocyte proliferation lymphocyte activation involved in immune response lymphocyte activation lymphocyte differentiation lymphocyte proliferation membrane-enclosed lumen membrane molecular function activator activity molecular function regulator activity molecular transducer activity molecular_function mononuclear cell differentiation mononuclear cell proliferation multicellular organismal process natural killer cell activation involved in immune response natural killer cell activation negative regulation of biological process negative regulation of biosynthetic process negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of cell communication negative regulation of cell population proliferation negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of cellular response to growth factor stimulus negative regulation of cellular response to vascular endothelial growth factor stimulus negative regulation of cytokine production negative regulation of defense response negative regulation of endothelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of establishment of protein localization negative regulation of gene expression negative regulation of immune response negative regulation of immune system process negative regulation of inflammatory response to antigenic stimulus negative regulation of inflammatory response negative regulation of interleukin-10 production negative regulation of interleukin-17 production negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process negative regulation of protein localization negative regulation of protein secretion negative regulation of protein transport negative regulation of response to external stimulus negative regulation of response to stimulus negative regulation of secretion by cell negative regulation of secretion negative regulation of signal transduction negative regulation of signaling negative regulation of smooth muscle cell proliferation negative regulation of transport negative regulation of vascular endothelial growth factor signaling pathway organelle lumen positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of NK T cell activation positive regulation of NK T cell proliferation positive regulation of T cell activation positive regulation of T cell differentiation positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immunity positive regulation of T cell proliferation positive regulation of T-helper 1 type immune response positive regulation of T-helper 17 cell differentiation positive regulation of T-helper 17 cell lineage commitment positive regulation of T-helper 17 type immune response positive regulation of T-helper cell differentiation positive regulation of activated T cell proliferation positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation positive regulation of apoptotic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of cell activation positive regulation of cell adhesion positive regulation of cell communication positive regulation of cell development positive regulation of cell differentiation positive regulation of cell fate commitment positive regulation of cell killing positive regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cytokine production positive regulation of defense response to virus by host positive regulation of defense response positive regulation of developmental process positive regulation of gene expression positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of hemopoiesis positive regulation of immune effector process positive regulation of immune response to tumor cell positive regulation of immune response positive regulation of immune system process positive regulation of inflammatory response positive regulation of innate immune response positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of intracellular signal transduction positive regulation of leukocyte activation positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte differentiation positive regulation of leukocyte mediated cytotoxicity positive regulation of leukocyte mediated immunity positive regulation of leukocyte proliferation positive regulation of lymphocyte activation positive regulation of lymphocyte differentiation positive regulation of lymphocyte mediated immunity positive regulation of lymphocyte proliferation positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of memory T cell differentiation positive regulation of metabolic process positive regulation of mononuclear cell proliferation positive regulation of multicellular organismal process positive regulation of muscle cell apoptotic process positive regulation of myeloid cell differentiation positive regulation of myeloid leukocyte differentiation positive regulation of natural killer cell activation positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated immune response to tumor cell positive regulation of natural killer cell mediated immunity positive regulation of natural killer cell proliferation positive regulation of nitrogen compound metabolic process positive regulation of non-canonical NF-kappaB signal transduction positive regulation of osteoclast differentiation positive regulation of programmed cell death positive regulation of protein metabolic process positive regulation of response to biotic stimulus positive regulation of response to external stimulus positive regulation of response to stimulus positive regulation of response to tumor cell positive regulation of signal transduction positive regulation of signaling positive regulation of smooth muscle cell apoptotic process positive regulation of tissue remodeling positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of type II interferon production protein binding protein dimerization activity protein heterodimerization activity protein-containing complex binding protein-containing complex receptor complex receptor ligand activity receptor signaling pathway via JAK-STAT receptor signaling pathway via STAT regulation of CD4-positive, alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell differentiation regulation of NK T cell activation regulation of NK T cell proliferation regulation of T cell activation regulation of T cell differentiation regulation of T cell mediated cytotoxicity regulation of T cell mediated immunity regulation of T cell proliferation regulation of T-helper 1 type immune response regulation of T-helper 17 cell differentiation regulation of T-helper 17 cell lineage commitment regulation of T-helper 17 type immune response regulation of T-helper cell differentiation regulation of activated T cell proliferation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of alpha-beta T cell activation regulation of alpha-beta T cell differentiation regulation of alpha-beta T cell proliferation regulation of apoptotic process regulation of biological process regulation of biosynthetic process regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of cell activation regulation of cell adhesion regulation of cell communication regulation of cell development regulation of cell differentiation regulation of cell fate commitment regulation of cell killing regulation of cell population proliferation regulation of cell-cell adhesion regulation of cellular biosynthetic process regulation of cellular localization regulation of cellular metabolic process regulation of cellular process regulation of cellular response to growth factor stimulus regulation of cellular response to vascular endothelial growth factor stimulus regulation of cytokine production regulation of defense response to virus by host regulation of defense response to virus regulation of defense response regulation of developmental process regulation of endothelial cell proliferation regulation of epithelial cell proliferation regulation of establishment of protein localization regulation of gene expression regulation of granulocyte macrophage colony-stimulating factor production regulation of hemopoiesis regulation of immune effector process regulation of immune response to tumor cell regulation of immune response regulation of immune system process regulation of inflammatory response to antigenic stimulus regulation of inflammatory response regulation of innate immune response regulation of interleukin-10 production regulation of interleukin-12 production regulation of interleukin-17 production regulation of intracellular signal transduction regulation of leukocyte activation regulation of leukocyte cell-cell adhesion regulation of leukocyte differentiation regulation of leukocyte mediated cytotoxicity regulation of leukocyte mediated immunity regulation of leukocyte proliferation regulation of localization regulation of lymphocyte activation regulation of lymphocyte differentiation regulation of lymphocyte mediated immunity regulation of lymphocyte proliferation regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of memory T cell differentiation regulation of metabolic process regulation of mononuclear cell proliferation regulation of multicellular organismal development regulation of multicellular organismal process regulation of muscle cell apoptotic process regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation regulation of natural killer cell activation regulation of natural killer cell mediated cytotoxicity directed against tumor cell target regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell mediated immune response to tumor cell regulation of natural killer cell mediated immunity regulation of natural killer cell proliferation regulation of nitrogen compound metabolic process regulation of non-canonical NF-kappaB signal transduction regulation of osteoclast differentiation regulation of primary metabolic process regulation of programmed cell death regulation of protein localization regulation of protein metabolic process regulation of protein secretion regulation of protein transport regulation of response to biotic stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of response to tumor cell regulation of secretion by cell regulation of secretion regulation of signal transduction regulation of signaling regulation of smooth muscle cell apoptotic process regulation of smooth muscle cell proliferation regulation of tissue remodeling regulation of transport regulation of tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of type II interferon production regulation of vascular endothelial growth factor signaling pathway reproduction response to UV-B response to UV response to abiotic stimulus response to bacterium response to biotic stimulus response to chemical response to cytokine response to external biotic stimulus response to external stimulus response to light stimulus response to lipid response to lipopolysaccharide response to molecule of bacterial origin response to organic substance response to other organism response to oxygen-containing compound response to protozoan response to radiation response to stimulus response to stress response to type II interferon response to virus sexual reproduction side of membrane signal transduction signaling receptor activator activity signaling receptor activity signaling receptor binding signaling receptor regulator activity transmembrane signaling receptor activity	GO:0000003 GO:0001562 GO:0001775 GO:0001817 GO:0001818 GO:0001819 GO:0001910 GO:0001912 GO:0001914 GO:0001916 GO:0001936 GO:0001937 GO:0002230 GO:0002237 GO:0002250 GO:0002252 GO:0002263 GO:0002285 GO:0002286 GO:0002287 GO:0002292 GO:0002293 GO:0002294 GO:0002323 GO:0002366 GO:0002376 GO:0002460 GO:0002521 GO:0002682 GO:0002683 GO:0002684 GO:0002694 GO:0002696 GO:0002697 GO:0002699 GO:0002703 GO:0002705 GO:0002706 GO:0002708 GO:0002709 GO:0002711 GO:0002715 GO:0002717 GO:0002761 GO:0002763 GO:0002819 GO:0002821 GO:0002822 GO:0002824 GO:0002825 GO:0002827 GO:0002831 GO:0002833 GO:0002834 GO:0002836 GO:0002837 GO:0002839 GO:0002855 GO:0002857 GO:0002858 GO:0002860 GO:0002861 GO:0002862 GO:0003674 GO:0004888 GO:0004896 GO:0005102 GO:0005125 GO:0005126 GO:0005143 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0005788 GO:0005829 GO:0006950 GO:0006952 GO:0006955 GO:0007165 GO:0007166 GO:0007259 GO:0008083 GO:0008150 GO:0008283 GO:0008284 GO:0008285 GO:0009314 GO:0009411 GO:0009416 GO:0009605 GO:0009607 GO:0009615 GO:0009617 GO:0009628 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009897 GO:0009966 GO:0009967 GO:0009968 GO:0009986 GO:0009987 GO:0010033 GO:0010224 GO:0010453 GO:0010455 GO:0010468 GO:0010556 GO:0010557 GO:0010558 GO:0010604 GO:0010605 GO:0010628 GO:0010629 GO:0010646 GO:0010647 GO:0010648 GO:0010660 GO:0010661 GO:0010720 GO:0016020 GO:0016477 GO:0019221 GO:0019222 GO:0019953 GO:0019955 GO:0019972 GO:0022407 GO:0022409 GO:0023051 GO:0023056 GO:0023057 GO:0030098 GO:0030101 GO:0030154 GO:0030155 GO:0030217 GO:0030545 GO:0030546 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031341 GO:0031343 GO:0031347 GO:0031348 GO:0031349 GO:0031904 GO:0031906 GO:0031974 GO:0032101 GO:0032102 GO:0032103 GO:0032496 GO:0032501 GO:0032502 GO:0032645 GO:0032649 GO:0032653 GO:0032655 GO:0032660 GO:0032680 GO:0032693 GO:0032700 GO:0032725 GO:0032729 GO:0032733 GO:0032735 GO:0032740 GO:0032760 GO:0032814 GO:0032816 GO:0032817 GO:0032819 GO:0032879 GO:0032880 GO:0032943 GO:0032944 GO:0032946 GO:0032991 GO:0033993 GO:0034097 GO:0034103 GO:0034105 GO:0034341 GO:0034391 GO:0034393 GO:0035710 GO:0035722 GO:0038023 GO:0042088 GO:0042093 GO:0042098 GO:0042102 GO:0042104 GO:0042110 GO:0042127 GO:0042129 GO:0042164 GO:0042221 GO:0042269 GO:0042742 GO:0042802 GO:0042832 GO:0042981 GO:0043065 GO:0043067 GO:0043068 GO:0043207 GO:0043233 GO:0043235 GO:0043367 GO:0043370 GO:0043372 GO:0043380 GO:0043382 GO:0043514 GO:0044419 GO:0044877 GO:0045088 GO:0045089 GO:0045321 GO:0045519 GO:0045580 GO:0045582 GO:0045595 GO:0045597 GO:0045619 GO:0045621 GO:0045622 GO:0045624 GO:0045637 GO:0045639 GO:0045670 GO:0045672 GO:0045785 GO:0045954 GO:0046006 GO:0046631 GO:0046632 GO:0046634 GO:0046635 GO:0046637 GO:0046638 GO:0046640 GO:0046641 GO:0046649 GO:0046651 GO:0046982 GO:0046983 GO:0048018 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048660 GO:0048662 GO:0048869 GO:0048870 GO:0050670 GO:0050671 GO:0050678 GO:0050680 GO:0050688 GO:0050691 GO:0050708 GO:0050709 GO:0050727 GO:0050728 GO:0050729 GO:0050776 GO:0050777 GO:0050778 GO:0050789 GO:0050793 GO:0050794 GO:0050829 GO:0050863 GO:0050865 GO:0050867 GO:0050870 GO:0050896 GO:0051046 GO:0051048 GO:0051049 GO:0051051 GO:0051094 GO:0051133 GO:0051135 GO:0051140 GO:0051142 GO:0051171 GO:0051173 GO:0051223 GO:0051224 GO:0051239 GO:0051240 GO:0051241 GO:0051246 GO:0051247 GO:0051249 GO:0051251 GO:0051607 GO:0051707 GO:0051716 GO:0060089 GO:0060255 GO:0060284 GO:0060341 GO:0065007 GO:0070013 GO:0070201 GO:0070661 GO:0070663 GO:0070665 GO:0070743 GO:0070851 GO:0070887 GO:0071216 GO:0071219 GO:0071222 GO:0071310 GO:0071345 GO:0071346 GO:0071396 GO:0080090 GO:0080134 GO:0090287 GO:0090288 GO:0097696 GO:0098542 GO:0098552 GO:0098772 GO:0110165 GO:0140375 GO:0140546 GO:0140677 GO:1900746 GO:1900747 GO:1901222 GO:1901224 GO:1901700 GO:1901701 GO:1902105 GO:1902107 GO:1902531 GO:1902533 GO:1902547 GO:1902548 GO:1903037 GO:1903039 GO:1903131 GO:1903530 GO:1903531 GO:1903555 GO:1903557 GO:1903587 GO:1903588 GO:1903706 GO:1903708 GO:1903828 GO:1904950 GO:2000026 GO:2000316 GO:2000318 GO:2000319 GO:2000321 GO:2000328 GO:2000330 GO:2000514 GO:2000516
256710	GLIPR1 like 1	GLIPR1L1 Aliases: MGC26856	Homo sapiens (human)	9606			acrosomal vesicle biological_process cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular process involved in reproduction in multicellular organism cellular process cellular_component cytoplasmic vesicle extracellular space fusion of sperm to egg plasma membrane involved in single fertilization intracellular membrane-bounded organelle intracellular organelle intracellular vesicle membrane fusion membrane microdomain membrane organization membrane raft membrane-bounded organelle membrane organelle plasma membrane fusion plasma membrane organization plasma membrane protein complex involved in cell adhesion protein complex involved in cell-cell adhesion protein-containing complex reproduction reproductive process secretory granule secretory vesicle sexual reproduction side of membrane vesicle	GO:0000003 GO:0001669 GO:0005575 GO:0005615 GO:0005886 GO:0007009 GO:0007342 GO:0008150 GO:0009987 GO:0016020 GO:0016043 GO:0019953 GO:0022412 GO:0022414 GO:0030141 GO:0031410 GO:0031982 GO:0032991 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0045026 GO:0045121 GO:0061024 GO:0061025 GO:0071840 GO:0097708 GO:0098552 GO:0098635 GO:0098636 GO:0098857 GO:0099503 GO:0110165
7458	eukaryotic translation initiation factor 4H	EIF4H	Homo sapiens (human)	9606	Williams-Beuren syndrome	DOID:1928	RNA binding RNA cap binding complex RNA strand annealing activity RNA strand-exchange activity annealing activity binding biological regulation biological_process cadherin binding cell adhesion molecule binding cellular anatomical entity cellular component assembly cellular component organization or biogenesis cellular component organization cellular process cellular_component cytosol developmental growth double-stranded RNA binding eukaryotic translation initiation factor 4F complex assembly eukaryotic translation initiation factor 4F complex formation of translation preinitiation complex growth intracellular protein-containing complex membrane molecular_function nucleic acid binding organic cyclic compound binding perinuclear region of cytoplasm post-transcriptional regulation of gene expression protein binding protein-RNA complex assembly protein-RNA complex organization protein-containing complex assembly protein-containing complex binding protein-containing complex organization protein-containing complex regulation of amide metabolic process regulation of biological process regulation of biosynthetic process regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of gene expression regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of nitrogen compound metabolic process regulation of primary metabolic process regulation of protein metabolic process regulation of translation regulation of translational initiation reproduction ribonucleoprotein complex binding ribosomal small subunit binding ribosome binding sexual reproduction single-stranded RNA binding translation factor activity, RNA binding translation initiation factor activity translation regulator activity, nucleic acid binding translation regulator activity	GO:0000003 GO:0001731 GO:0003674 GO:0003676 GO:0003723 GO:0003725 GO:0003727 GO:0003743 GO:0005488 GO:0005515 GO:0005575 GO:0005829 GO:0006417 GO:0006446 GO:0008135 GO:0008150 GO:0009889 GO:0009987 GO:0010468 GO:0010556 GO:0010608 GO:0016020 GO:0016043 GO:0016281 GO:0019222 GO:0019953 GO:0022607 GO:0022618 GO:0031323 GO:0031326 GO:0032991 GO:0033592 GO:0034057 GO:0034248 GO:0034518 GO:0040007 GO:0043021 GO:0043022 GO:0043024 GO:0043933 GO:0044877 GO:0045182 GO:0045296 GO:0048471 GO:0048589 GO:0050789 GO:0050794 GO:0050839 GO:0051171 GO:0051246 GO:0060255 GO:0065003 GO:0065007 GO:0071826 GO:0071840 GO:0080090 GO:0090079 GO:0097010 GO:0097159 GO:0110165 GO:0140535 GO:0140666
6414	selenoprotein P	SELENOP	Homo sapiens (human)	9606			anatomical structure development animal organ development behavior binding biological regulation biological_process brain development cellular anatomical entity cellular metabolic process cellular process cellular_component cytoplasmic vesicle lumen developmental process extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular region extracellular vesicle intracellular organelle lumen locomotory behavior membrane-bounded organelle membrane-enclosed lumen metabolic process molecular_function multicellular organismal process organelle lumen organelle platelet dense granule lumen post-embryonic development regulation of biological process regulation of growth reproduction response to chemical response to inorganic substance response to oxidative stress response to selenium ion response to stimulus response to stress secretory granule lumen selenium binding selenium compound metabolic process sexual reproduction vesicle lumen vesicle	GO:0000003 GO:0001887 GO:0003674 GO:0005488 GO:0005575 GO:0005576 GO:0006950 GO:0006979 GO:0007420 GO:0007610 GO:0007626 GO:0008150 GO:0008152 GO:0008430 GO:0009791 GO:0009987 GO:0010035 GO:0010269 GO:0019953 GO:0031089 GO:0031974 GO:0031982 GO:0031983 GO:0032501 GO:0032502 GO:0034774 GO:0040008 GO:0042221 GO:0043226 GO:0043227 GO:0043230 GO:0043233 GO:0044237 GO:0048513 GO:0048856 GO:0050789 GO:0050896 GO:0060205 GO:0065007 GO:0065010 GO:0070013 GO:0070062 GO:0110165 GO:1903561
10321	cysteine rich secretory protein 3	CRISP3	Homo sapiens (human)	9606			binding biological process involved in interspecies interaction between organisms biological_process cellular anatomical entity cellular_component cytoplasmic vesicle lumen cytoplasmic vesicle defense response to other organism defense response external encapsulating structure extracellular matrix extracellular region extracellular space immune response immune system process innate immune response intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle intracellular vesicle membrane-bounded organelle membrane-enclosed lumen molecular_function organelle lumen organelle protein binding reproduction response to biotic stimulus response to external biotic stimulus response to external stimulus response to other organism response to stimulus response to stress secretory granule lumen secretory granule secretory vesicle sexual reproduction specific granule lumen specific granule tertiary granule lumen vesicle lumen vesicle	GO:0000003 GO:0002376 GO:0003674 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0006950 GO:0006952 GO:0006955 GO:0008150 GO:0009605 GO:0009607 GO:0019953 GO:0030141 GO:0030312 GO:0031012 GO:0031410 GO:0031974 GO:0031982 GO:0031983 GO:0034774 GO:0035580 GO:0042581 GO:0043207 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0044419 GO:0045087 GO:0050896 GO:0051707 GO:0060205 GO:0070013 GO:0097708 GO:0098542 GO:0099503 GO:0110165 GO:1904724
167	cysteine rich secretory protein 1	CRISP1	Homo sapiens (human)	9606			binding of sperm to zona pellucida biological regulation biological_process calcium channel regulator activity cell recognition cell-cell recognition cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular process involved in reproduction in multicellular organism cellular process cellular_component channel regulator activity extracellular space fusion of sperm to egg plasma membrane involved in single fertilization intracellular membrane-bounded organelle intracellular organelle ion channel regulator activity membrane fusion membrane organization membrane-bounded organelle molecular function regulator activity molecular_function nucleus organelle plasma membrane fusion plasma membrane organization regulation of acrosome reaction regulation of biological process regulation of reproductive process reproduction reproductive process sexual reproduction sperm-egg recognition transporter regulator activity	GO:0000003 GO:0003674 GO:0005246 GO:0005575 GO:0005615 GO:0005634 GO:0007009 GO:0007339 GO:0007342 GO:0008037 GO:0008150 GO:0009987 GO:0009988 GO:0016043 GO:0016247 GO:0019953 GO:0022412 GO:0022414 GO:0035036 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0045026 GO:0050789 GO:0060046 GO:0061024 GO:0061025 GO:0065007 GO:0071840 GO:0098772 GO:0099106 GO:0110165 GO:0141108 GO:2000241
55650	phosphatidylinositol glycan anchor biosynthesis class V	PIGV Aliases: FLJ20477 GPI mannosyltransferase 2 GPI-MT-II PIG-V dol-P-Man dependent GPI mannosyltransferase II	Homo sapiens (human)	9606	hyperphosphatasia with impaired intellectual development syndrome 1	DOID:0070433	GPI anchor biosynthetic process GPI anchor metabolic process alpha-1,6-mannosyltransferase activity binding biological_process biosynthetic process carbohydrate derivative biosynthetic process carbohydrate derivative metabolic process catalytic activity catalytic complex cellular anatomical entity cellular biosynthetic process cellular lipid metabolic process cellular metabolic process cellular process cellular_component endoplasmic reticulum membrane glycerolipid biosynthetic process glycerolipid metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process glycolipid biosynthetic process glycolipid mannosyltransferase activity glycolipid metabolic process glycosyltransferase activity hexosyltransferase activity intracellular protein-containing complex lipid biosynthetic process lipid metabolic process liposaccharide metabolic process macromolecule metabolic process macromolecule modification mannosyltransferase activity mannosyltransferase complex membrane lipid biosynthetic process membrane lipid metabolic process membrane metabolic process molecular_function nitrogen compound metabolic process organelle membrane organic substance biosynthetic process organic substance metabolic process organonitrogen compound metabolic process organophosphate biosynthetic process organophosphate metabolic process phosphate-containing compound metabolic process phosphatidylinositol biosynthetic process phosphatidylinositol metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphorus metabolic process preassembly of GPI anchor in ER membrane primary metabolic process protein binding protein lipidation protein metabolic process protein modification process protein-containing complex transferase activity transferase complex	GO:0000009 GO:0000030 GO:0003674 GO:0003824 GO:0004376 GO:0005488 GO:0005515 GO:0005575 GO:0005789 GO:0006497 GO:0006505 GO:0006506 GO:0006629 GO:0006643 GO:0006644 GO:0006650 GO:0006661 GO:0006664 GO:0006793 GO:0006796 GO:0006807 GO:0008150 GO:0008152 GO:0008610 GO:0008654 GO:0009058 GO:0009247 GO:0009987 GO:0016020 GO:0016254 GO:0016740 GO:0016757 GO:0016758 GO:0019538 GO:0019637 GO:0031090 GO:0031501 GO:0032991 GO:0036211 GO:0043170 GO:0043412 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0045017 GO:0046467 GO:0046474 GO:0046486 GO:0046488 GO:0071704 GO:0090407 GO:0110165 GO:0140535 GO:1901135 GO:1901137 GO:1901564 GO:1901576 GO:1902494 GO:1903509 GO:1990234
79087	ALG12 alpha-1,6-mannosyltransferase	ALG12 Aliases: CDG1G ECM39 dol-P-Man dependent alpha-1,6-mannosyltransferase dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase	Homo sapiens (human)	9606	congenital disorder of glycosylation Ig	DOID:0080559	alcohol metabolic process alpha-1,6-mannosyltransferase activity biological_process biosynthetic process carbohydrate derivative biosynthetic process carbohydrate derivative metabolic process catalytic activity cellular anatomical entity cellular lipid metabolic process cellular metabolic process cellular process cellular_component dolichol metabolic process dolichol-linked oligosaccharide biosynthetic process dolichyl-P-Man endoplasmic reticulum membrane endoplasmic reticulum glycosylation glycosyltransferase activity hexosyltransferase activity intracellular membrane-bounded organelle intracellular organelle isoprenoid metabolic process lipid metabolic process lumenal side of endoplasmic reticulum membrane lumenal side of membrane macromolecule glycosylation macromolecule metabolic process macromolecule modification mannosyltransferase activity membrane-bounded organelle membrane metabolic process molecular_function nitrogen compound metabolic process oligosaccharide-lipid intermediate biosynthetic process organelle membrane organelle organic hydroxy compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound metabolic process polyprenol metabolic process primary metabolic process protein N-linked glycosylation protein folding protein glycosylation protein metabolic process protein modification process side of membrane small molecule metabolic process transferase activity	GO:0000009 GO:0000030 GO:0003674 GO:0003824 GO:0005575 GO:0005783 GO:0005789 GO:0006066 GO:0006457 GO:0006486 GO:0006487 GO:0006488 GO:0006490 GO:0006629 GO:0006720 GO:0006807 GO:0008150 GO:0008152 GO:0009058 GO:0009987 GO:0016020 GO:0016093 GO:0016740 GO:0016757 GO:0016758 GO:0019348 GO:0019538 GO:0031090 GO:0036211 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043412 GO:0043413 GO:0044237 GO:0044238 GO:0044255 GO:0044281 GO:0052917 GO:0070085 GO:0071704 GO:0098552 GO:0098553 GO:0098576 GO:0110165 GO:1901135 GO:1901137 GO:1901564 GO:1901576 GO:1901615
7515	X-ray repair cross complementing 1	XRCC1	Homo sapiens (human)	9606	acute lymphoblastic leukemia autosomal recessive spinocerebellar ataxia 26 brain glioma central nervous system cancer cervical cancer chronic myeloid leukemia colorectal adenocarcinoma colorectal cancer colorectal carcinoma contact dermatitis coronary artery disease diabetic retinopathy esophageal cancer esophagus squamous cell carcinoma gallbladder cancer gastric cardia adenocarcinoma gastric cardia carcinoma glioblastoma hepatitis A hepatitis B hepatocellular carcinoma high grade glioma hypertension impotence invasive ductal carcinoma laryngeal carcinoma leiomyoma liver cirrhosis lung adenocarcinoma lung cancer lung non-small cell carcinoma malignant mesothelioma meningioma myelodysplastic syndrome nasopharynx carcinoma oral mucosa leukoplakia pancreatic cancer papillary thyroid carcinoma prostate cancer renal cell carcinoma seminoma senile cataract stomach cancer stomach carcinoma transitional cell carcinoma type 2 diabetes mellitus urinary bladder cancer	DOID:0050861 DOID:0050908 DOID:0060108 DOID:0080199 DOID:0080260 DOID:10283 DOID:10534 DOID:10763 DOID:11054 DOID:12549 DOID:127 DOID:1324 DOID:1790 DOID:1793 DOID:1875 DOID:2043 DOID:2600 DOID:2671 DOID:2773 DOID:3008 DOID:3068 DOID:3070 DOID:3121 DOID:3393 DOID:3565 DOID:3620 DOID:3748 DOID:3908 DOID:3910 DOID:3969 DOID:4362 DOID:4440 DOID:4450 DOID:5041 DOID:5082 DOID:5517 DOID:6270 DOID:6271 DOID:684 DOID:8552 DOID:8947 DOID:9256 DOID:9261 DOID:9352 DOID:9655 DOID:9669 DOID:9952	3' overhang single-stranded DNA endodeoxyribonuclease activity ADP-D-ribose modification-dependent protein binding DNA binding DNA damage response DNA endonuclease activity DNA metabolic process DNA nuclease activity DNA recombination DNA repair ERCC4-ERCC1 complex anatomical structure development anatomical structure morphogenesis base-excision repair binding biological regulation biological_process carbohydrate derivative binding catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity cellular anatomical entity cellular aromatic compound metabolic process cellular component organization or biogenesis cellular component organization cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular response to stimulus cellular response to stress cellular_component cerebellum morphogenesis chromatin chromosomal region chromosome organization chromosome, telomeric region damaged DNA binding developmental process double-strand break repair via homologous recombination double-strand break repair via nonhomologous end joining double-strand break repair endonuclease activity enzyme binding heterocycle metabolic process hippocampus development hydrolase activity, acting on ester bonds hydrolase activity intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle macromolecule metabolic process membrane-bounded organelle metabolic process mitotic recombination modification-dependent protein binding molecular_function multicellular organismal movement multicellular organismal process musculoskeletal movement negative regulation of DNA metabolic process negative regulation of biological process negative regulation of catalytic activity negative regulation of cellular component organization negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of chromosome organization negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of molecular function negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of organelle organization negative regulation of protection from non-homologous end joining at telomere negative regulation of protein ADP-ribosylation negative regulation of response to stimulus negative regulation of telomere capping negative regulation of telomere maintenance in response to DNA damage negative regulation of telomere maintenance negative regulation of transferase activity nervous system process neuromuscular process nitrogen compound metabolic process non-membrane-bounded organelle nuclear protein-containing complex nuclease activity nucleic acid binding nucleic acid metabolic process nucleobase-containing compound metabolic process nucleolus nucleoplasm nucleotide-excision repair complex nucleus organelle organization organelle organic cyclic compound binding organic cyclic compound metabolic process organic substance metabolic process oxidized DNA binding poly-ADP-D-ribose binding positive regulation of DNA ligase activity positive regulation of DNA ligation positive regulation of DNA metabolic process positive regulation of DNA repair positive regulation of biological process positive regulation of catalytic activity positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of ligase activity positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of single strand break repair primary metabolic process protein binding protein-DNA complex protein-containing complex recombinational repair regulation of DNA ligase activity regulation of DNA ligation regulation of DNA metabolic process regulation of DNA repair regulation of biological process regulation of catalytic activity regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cellular response to stress regulation of chromosome organization regulation of ligase activity regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of organelle organization regulation of primary metabolic process regulation of protection from non-homologous end joining at telomere regulation of protein ADP-ribosylation regulation of response to stimulus regulation of response to stress regulation of single strand break repair regulation of telomere capping regulation of telomere maintenance in response to DNA damage regulation of telomere maintenance regulation of transferase activity replication-born double-strand break repair via sister chromatid exchange response to abiotic stimulus response to chemical response to decreased oxygen levels response to hydroperoxide response to hypoxia response to oxidative stress response to oxygen levels response to oxygen-containing compound response to stimulus response to stress response to xenobiotic stimulus single strand break repair single-stranded DNA endodeoxyribonuclease activity site of DNA damage system process telomere maintenance via recombination telomere maintenance telomere organization telomeric DNA-containing double minutes formation voluntary musculoskeletal movement	GO:0000012 GO:0000014 GO:0000109 GO:0000722 GO:0000723 GO:0000724 GO:0000725 GO:0000781 GO:0000785 GO:0001666 GO:0003008 GO:0003674 GO:0003676 GO:0003677 GO:0003684 GO:0003824 GO:0004518 GO:0004519 GO:0004520 GO:0004536 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005730 GO:0006139 GO:0006259 GO:0006281 GO:0006282 GO:0006284 GO:0006302 GO:0006303 GO:0006310 GO:0006312 GO:0006725 GO:0006807 GO:0006950 GO:0006974 GO:0006979 GO:0006996 GO:0008150 GO:0008152 GO:0009410 GO:0009628 GO:0009653 GO:0009892 GO:0009893 GO:0009987 GO:0010604 GO:0010605 GO:0010639 GO:0010835 GO:0010836 GO:0016043 GO:0016787 GO:0016788 GO:0019219 GO:0019222 GO:0019899 GO:0021587 GO:0021766 GO:0031323 GO:0031324 GO:0031325 GO:0032200 GO:0032204 GO:0032205 GO:0032356 GO:0032501 GO:0032502 GO:0032991 GO:0032993 GO:0033043 GO:0033044 GO:0033194 GO:0033554 GO:0034641 GO:0036293 GO:0042221 GO:0043085 GO:0043086 GO:0043170 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0044092 GO:0044093 GO:0044237 GO:0044238 GO:0045739 GO:0045934 GO:0045935 GO:0046483 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048856 GO:0050789 GO:0050790 GO:0050794 GO:0050877 GO:0050879 GO:0050881 GO:0050882 GO:0050896 GO:0050905 GO:0051052 GO:0051053 GO:0051054 GO:0051105 GO:0051106 GO:0051128 GO:0051129 GO:0051171 GO:0051172 GO:0051173 GO:0051276 GO:0051338 GO:0051340 GO:0051348 GO:0051351 GO:0051716 GO:0060255 GO:0061819 GO:0065007 GO:0065009 GO:0070482 GO:0070522 GO:0071704 GO:0071840 GO:0072572 GO:0080090 GO:0080134 GO:0080135 GO:0090304 GO:0090734 GO:0097159 GO:0097367 GO:0098687 GO:0110165 GO:0140030 GO:0140097 GO:0140513 GO:0140640 GO:0160002 GO:1901360 GO:1901700 GO:1903516 GO:1903518 GO:1904353 GO:1904354 GO:1904505 GO:1904506 GO:1904875 GO:1904877 GO:1905764 GO:1905765 GO:1990414 GO:1990599 GO:2001251
2074	ERCC excision repair 6, chromatin remodeling factor	ERCC6	Homo sapiens (human)	9606	Cockayne syndrome B Cockayne syndrome De Sanctis-Cacchione syndrome UV-sensitive syndrome age related macular degeneration 5 cerebrooculofacioskeletal syndrome 1 colorectal cancer colorectal carcinoma larynx cancer lung cancer lung non-small cell carcinoma polyneuropathy due to drug primary ovarian insufficiency 11 stomach cancer	DOID:0060240 DOID:0080199 DOID:0080868 DOID:0080908 DOID:0080911 DOID:0110028 DOID:0112158 DOID:10534 DOID:1324 DOID:14184 DOID:2596 DOID:2962 DOID:3908 DOID:9256	ATP binding ATP hydrolysis activity ATP-dependent activity, acting on DNA ATP-dependent activity ATP-dependent chromatin remodeler activity ATPase complex B-WICH complex DNA binding DNA damage checkpoint signaling DNA damage response DNA helicase activity DNA integrity checkpoint signaling DNA metabolic process DNA protection DNA repair DNA-templated transcription elongation DNA-templated transcription JNK cascade MAPK cascade RNA biosynthetic process RNA metabolic process RNA polymerase binding SWI/SNF superfamily-type complex adenyl nucleotide binding adenyl ribonucleotide binding anion binding apoptotic signaling pathway aromatic compound biosynthetic process base-excision repair binding biological regulation biological_process biosynthetic process carbohydrate derivative binding catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity catalytic complex cell communication cell cycle checkpoint signaling cell differentiation cell projection organization cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular component organization or biogenesis cellular component organization cellular developmental process cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular response to external stimulus cellular response to extracellular stimulus cellular response to stimulus cellular response to stress cellular_component chromatin binding chromatin organization chromatin remodeling developmental growth developmental process double-strand break repair via classical nonhomologous end joining double-strand break repair via nonhomologous end joining double-strand break repair enzyme activator activity enzyme binding enzyme regulator activity growth helicase activity heterocycle biosynthetic process heterocycle metabolic process heterocyclic compound binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides hydrolase activity intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle intracellular signal transduction intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway ion binding kinase activator activity kinase regulator activity macromolecule biosynthetic process macromolecule metabolic process membrane-bounded organelle metabolic process molecular function activator activity molecular function regulator activity molecular_function multicellular organism growth multicellular organismal process negative regulation of DNA metabolic process negative regulation of DNA repair negative regulation of biological process negative regulation of cell cycle phase transition negative regulation of cell cycle process negative regulation of cell cycle negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of double-strand break repair via nonhomologous end joining negative regulation of double-strand break repair negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of response to stimulus neurogenesis neuron differentiation neuron projection development nitrogen compound metabolic process non-membrane-bounded organelle nuclear body nuclear protein-containing complex nucleic acid binding nucleic acid metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleolus nucleoplasm nucleoside phosphate binding nucleotide binding nucleotide-excision repair nucleus organelle organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process photoreceptor cell maintenance plasma membrane bounded cell projection organization positive regulation of DNA metabolic process positive regulation of DNA recombination positive regulation of DNA repair positive regulation of DNA-templated transcription initiation positive regulation of DNA-templated transcription, elongation positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of defense response to virus by host positive regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair positive regulation of gene expression positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of response to stimulus positive regulation of transcription by RNA polymerase I positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase III positive regulation of transcription initiation by RNA polymerase II primary metabolic process protein binding protein kinase activator activity protein kinase regulator activity protein tyrosine kinase activator activity protein-DNA complex organization protein-containing complex binding protein-containing complex organization protein-containing complex purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding pyrimidine dimer repair pyrophosphatase activity regulation of DNA metabolic process regulation of DNA recombination regulation of DNA repair regulation of DNA-templated transcription elongation regulation of DNA-templated transcription initiation regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of biological process regulation of biosynthetic process regulation of cell cycle phase transition regulation of cell cycle process regulation of cell cycle regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cellular response to stress regulation of defense response to virus by host regulation of defense response to virus regulation of defense response regulation of double-strand break repair via homologous recombination regulation of double-strand break repair via nonhomologous end joining regulation of double-strand break repair regulation of gene expression regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of peptidyl-serine phosphorylation of STAT protein regulation of peptidyl-serine phosphorylation regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of primary metabolic process regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of response to biotic stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress regulation of transcription by RNA polymerase I regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase III regulation of transcription elongation by RNA polymerase II regulation of transcription initiation by RNA polymerase II response to UV-B response to UV response to X-ray response to abiotic stimulus response to chemical response to external stimulus response to extracellular stimulus response to gamma radiation response to inorganic substance response to ionizing radiation response to light stimulus response to oxidative stress response to oxygen radical response to oxygen-containing compound response to radiation response to reactive oxygen species response to stimulus response to stress response to superoxide response to toxic substance ribonucleoside triphosphate phosphatase activity ribonucleotide binding sequence-specific DNA binding signal transduction in response to DNA damage signal transduction single strand break repair site of DNA damage small molecule binding stress-activated MAPK cascade stress-activated protein kinase signaling cascade transcription by RNA polymerase II transcription elongation by RNA polymerase I transcription elongation factor complex transcription-coupled nucleotide-excision repair	GO:0000012 GO:0000018 GO:0000075 GO:0000077 GO:0000165 GO:0000166 GO:0000302 GO:0000303 GO:0000305 GO:0001932 GO:0001934 GO:0002230 GO:0002831 GO:0003674 GO:0003676 GO:0003677 GO:0003678 GO:0003682 GO:0003824 GO:0004386 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005634 GO:0005654 GO:0005730 GO:0006139 GO:0006259 GO:0006281 GO:0006282 GO:0006283 GO:0006284 GO:0006289 GO:0006290 GO:0006302 GO:0006303 GO:0006325 GO:0006338 GO:0006351 GO:0006354 GO:0006355 GO:0006356 GO:0006357 GO:0006359 GO:0006362 GO:0006366 GO:0006725 GO:0006807 GO:0006950 GO:0006974 GO:0006979 GO:0007154 GO:0007165 GO:0007254 GO:0008023 GO:0008047 GO:0008094 GO:0008150 GO:0008152 GO:0008630 GO:0009058 GO:0009059 GO:0009314 GO:0009411 GO:0009416 GO:0009605 GO:0009628 GO:0009636 GO:0009889 GO:0009891 GO:0009892 GO:0009893 GO:0009987 GO:0009991 GO:0010035 GO:0010165 GO:0010212 GO:0010224 GO:0010332 GO:0010468 GO:0010556 GO:0010557 GO:0010562 GO:0010564 GO:0010569 GO:0010604 GO:0010605 GO:0010628 GO:0010948 GO:0016043 GO:0016070 GO:0016462 GO:0016604 GO:0016787 GO:0016817 GO:0016818 GO:0016887 GO:0017076 GO:0017111 GO:0018130 GO:0019207 GO:0019209 GO:0019219 GO:0019220 GO:0019222 GO:0019438 GO:0019887 GO:0019899 GO:0022008 GO:0030030 GO:0030154 GO:0030182 GO:0030234 GO:0030295 GO:0030296 GO:0030554 GO:0031098 GO:0031175 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031328 GO:0031347 GO:0031399 GO:0031401 GO:0031570 GO:0031668 GO:0032101 GO:0032501 GO:0032502 GO:0032553 GO:0032555 GO:0032559 GO:0032774 GO:0032784 GO:0032786 GO:0032991 GO:0033135 GO:0033138 GO:0033139 GO:0033141 GO:0033554 GO:0034243 GO:0034641 GO:0034654 GO:0035264 GO:0035556 GO:0035639 GO:0036094 GO:0040007 GO:0042221 GO:0042262 GO:0042325 GO:0042327 GO:0042770 GO:0043167 GO:0043168 GO:0043170 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043565 GO:0043933 GO:0044237 GO:0044238 GO:0044249 GO:0044271 GO:0044877 GO:0045494 GO:0045738 GO:0045739 GO:0045786 GO:0045893 GO:0045911 GO:0045934 GO:0045935 GO:0045937 GO:0045943 GO:0045944 GO:0045945 GO:0046483 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048589 GO:0048869 GO:0050688 GO:0050691 GO:0050789 GO:0050794 GO:0050896 GO:0051052 GO:0051053 GO:0051054 GO:0051171 GO:0051172 GO:0051173 GO:0051174 GO:0051246 GO:0051247 GO:0051252 GO:0051254 GO:0051403 GO:0051716 GO:0051726 GO:0060255 GO:0060260 GO:0060261 GO:0065007 GO:0070063 GO:0070603 GO:0071496 GO:0071704 GO:0071824 GO:0071840 GO:0080090 GO:0080134 GO:0080135 GO:0090304 GO:0090734 GO:0097159 GO:0097190 GO:0097193 GO:0097367 GO:0097680 GO:0098772 GO:0110016 GO:0110165 GO:0120036 GO:0140097 GO:0140513 GO:0140640 GO:0140657 GO:0140658 GO:0140677 GO:1901265 GO:1901360 GO:1901362 GO:1901363 GO:1901576 GO:1901700 GO:1901987 GO:1901988 GO:1902494 GO:1902680 GO:1904949 GO:1905168 GO:2000142 GO:2000144 GO:2000779 GO:2000780 GO:2000781 GO:2001032 GO:2001033 GO:2001141
23411	sirtuin 1	SIRT1	Homo sapiens (human)	9606	Huntington's disease	DOID:12858	DNA binding DNA biosynthetic process DNA damage response DNA metabolic process DNA methylation-dependent heterochromatin formation DNA repair-dependent chromatin remodeling DNA repair DNA synthesis involved in DNA repair DNA-binding transcription factor binding ESC/E(Z) complex HLH domain binding N-acyltransferase activity NAD binding NAD+ ADP-ribosyltransferase activity NAD+ binding NAD+-protein ADP-ribosyltransferase activity NAD-dependent histone H3K14 deacetylase activity NAD-dependent histone H3K18 deacetylase activity NAD-dependent histone H3K56 deacetylase activity NAD-dependent histone H3K9 deacetylase activity NAD-dependent histone H4K16 deacetylase activity NAD-dependent histone deacetylase activity NAD-dependent histone decrotonylase activity NAD-dependent protein deacetylase activity NAD-dependent protein decrotonylase activity PML body PcG protein complex RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding UV-damage excision repair acylglycerol homeostasis acylglycerol metabolic process acyltransferase activity, transferring groups other than amino-acyl groups acyltransferase activity adenyl nucleotide binding anatomical structure development anatomical structure formation involved in morphogenesis angiogenesis animal organ development anion binding apoptotic signaling pathway aromatic compound biosynthetic process bHLH transcription factor binding behavioral response to starvation binding biological regulation biological_process biosynthetic process carbohydrate homeostasis catabolic process catalytic activity, acting on a protein catalytic activity catalytic complex cation binding cell communication cell differentiation cell surface receptor signaling pathway cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular component organization or biogenesis cellular component organization cellular developmental process cellular homeostasis cellular lipid metabolic process cellular metabolic process cellular nitrogen compound biosynthetic process cellular nitrogen compound metabolic process cellular process cellular response to UV cellular response to abiotic stimulus cellular response to chemical stimulus cellular response to chemical stress cellular response to cytokine stimulus cellular response to decreased oxygen levels cellular response to environmental stimulus cellular response to external stimulus cellular response to extracellular stimulus cellular response to glucose starvation cellular response to hydrogen peroxide cellular response to hypoxia cellular response to ionizing radiation cellular response to leukemia inhibitory factor cellular response to light stimulus cellular response to nutrient levels cellular response to organic substance cellular response to oxidative stress cellular response to oxygen levels cellular response to oxygen-containing compound cellular response to radiation cellular response to reactive oxygen species cellular response to starvation cellular response to stimulus cellular response to stress cellular response to tumor necrosis factor cellular senescence cellular_component chemical homeostasis cholesterol homeostasis chromatin binding chromatin organization chromatin remodeling chromatin silencing complex chromatin circadian regulation of gene expression circadian rhythm cis-regulatory region sequence-specific DNA binding cytokine-mediated signaling pathway cytoplasm cytosol deacetylase activity developmental process involved in reproduction developmental process double-stranded DNA binding eNoSc complex energy homeostasis envelope enzyme activator activity enzyme binding enzyme regulator activity enzyme-linked receptor protein signaling pathway epigenetic regulation of gene expression euchromatin facultative heterochromatin formation fat cell differentiation fatty acid homeostasis fibrillar center gamete generation glucose homeostasis glycerolipid metabolic process glycosyltransferase activity heterochromatin formation heterochromatin organization heterochromatin heterocycle biosynthetic process heterocycle metabolic process heterocyclic compound binding histone H3K deacetylase activity histone H3K14 deacetylase activity histone H3K18 decrotonylase activity histone H3K9 deacetylase activity histone H4K deacetylase activity histone H4K12 deacetylase activity histone H4K16 deacetylase activity histone binding histone deacetylase activity histone decrotonylase activity histone methyltransferase complex histone modifying activity homeostatic process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity identical protein binding intermediate filament binding intracellular chemical homeostasis intracellular glucose homeostasis intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle intracellular signal transduction intracellular triglyceride homeostasis intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway ion binding keratin filament binding kinase binding leptin-mediated signaling pathway leukocyte differentiation lipid homeostasis lipid metabolic process localization macromolecule biosynthetic process macromolecule catabolic process macromolecule deacylation macromolecule metabolic process macromolecule modification macrophage differentiation maintenance of location in cell maintenance of location maintenance of nucleus location maintenance of organelle location male gamete generation membrane-bounded organelle membrane metabolic process metal ion binding methyltransferase complex mitochondrion mitogen-activated protein kinase binding modification-dependent macromolecule catabolic process modification-dependent protein catabolic process molecular function activator activity molecular function regulator activity molecular_function multicellular organismal process multicellular organismal reproductive process multicellular organismal-level homeostasis muscle organ development muscle structure development myeloid cell differentiation myeloid leukocyte differentiation negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of DNA-binding transcription factor activity negative regulation of DNA-templated transcription negative regulation of NF-kappaB transcription factor activity negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of TOR signaling negative regulation of androgen receptor signaling pathway negative regulation of apoptotic process negative regulation of apoptotic signaling pathway negative regulation of attachment of mitotic spindle microtubules to kinetochore negative regulation of attachment of spindle microtubules to kinetochore negative regulation of biological process negative regulation of biosynthetic process negative regulation of canonical NF-kappaB signal transduction negative regulation of cell communication negative regulation of cell cycle process negative regulation of cell cycle negative regulation of cell differentiation negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of cellular response to testosterone stimulus negative regulation of cellular senescence negative regulation of chromosome segregation negative regulation of developmental process negative regulation of fat cell differentiation negative regulation of fatty acid biosynthetic process negative regulation of fatty acid metabolic process negative regulation of gene expression, epigenetic negative regulation of gene expression negative regulation of hippo signaling negative regulation of intracellular signal transduction negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of intrinsic apoptotic signaling pathway negative regulation of lipid biosynthetic process negative regulation of lipid metabolic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of molecular function negative regulation of neuron apoptotic process negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of peptidyl-lysine acetylation negative regulation of phosphate metabolic process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphorus metabolic process negative regulation of phosphorylation negative regulation of programmed cell death negative regulation of prostaglandin biosynthetic process negative regulation of protein acetylation negative regulation of protein metabolic process negative regulation of protein modification process negative regulation of response to stimulus negative regulation of signal transduction by p53 class mediator negative regulation of signal transduction negative regulation of signaling negative regulation of small molecule metabolic process negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of triglyceride biosynthetic process negative regulation of triglyceride metabolic process neutral lipid metabolic process nitrogen compound metabolic process non-membrane-bounded organelle nuclear body nuclear envelope nuclear inner membrane nuclear membrane nuclear protein-containing complex nuclear receptor binding nucleic acid binding nucleic acid metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process nucleolus nucleoplasm nucleoside phosphate binding nucleotide binding nucleotide-excision repair nucleus localization nucleus organelle envelope organelle inner membrane organelle localization organelle membrane organelle organic cyclic compound binding organic cyclic compound biosynthetic process organic cyclic compound metabolic process organic substance biosynthetic process organic substance catabolic process organic substance metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process ovulation cycle process ovulation from ovarian follicle ovulation p53 binding pentosyltransferase activity peptidyl-amino acid modification peptidyl-lysine acetylation peptidyl-lysine modification positive regulation of DNA metabolic process positive regulation of DNA repair positive regulation of DNA-templated transcription positive regulation of MHC class II biosynthetic process positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of adaptive immune response positive regulation of adipose tissue development positive regulation of angiogenesis positive regulation of apoptotic process positive regulation of apoptotic signaling pathway positive regulation of autophagy positive regulation of biological process positive regulation of biosynthetic process positive regulation of blood vessel endothelial cell migration positive regulation of cAMP-dependent protein kinase activity positive regulation of carbohydrate metabolic process positive regulation of catabolic process positive regulation of catalytic activity positive regulation of cell communication positive regulation of cell differentiation positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cellular biosynthetic process positive regulation of cellular catabolic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cellular response to insulin stimulus positive regulation of cellular senescence positive regulation of cholesterol efflux positive regulation of cholesterol transport positive regulation of cysteine-type endopeptidase activity positive regulation of cytokine production involved in immune response positive regulation of cytokine production positive regulation of developmental process positive regulation of double-strand break repair positive regulation of endopeptidase activity positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of endothelial cell migration positive regulation of endothelial cell proliferation positive regulation of epithelial cell migration positive regulation of epithelial cell proliferation positive regulation of gene expression positive regulation of gluconeogenesis positive regulation of glucose metabolic process positive regulation of hydrolase activity positive regulation of immune effector process positive regulation of immune response positive regulation of immune system process positive regulation of insulin receptor signaling pathway positive regulation of intracellular signal transduction positive regulation of intrinsic apoptotic signaling pathway positive regulation of kinase activity positive regulation of leukocyte apoptotic process positive regulation of lipid localization positive regulation of lipid transport positive regulation of locomotion positive regulation of macroautophagy positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of macrophage apoptotic process positive regulation of macrophage cytokine production positive regulation of metabolic process positive regulation of molecular function positive regulation of multicellular organismal process positive regulation of muscle cell differentiation positive regulation of myeloid cell apoptotic process positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of peptidase activity positive regulation of phosphate metabolic process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphorus metabolic process positive regulation of phosphorylation positive regulation of production of molecular mediator of immune response positive regulation of programmed cell death positive regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process positive regulation of protein kinase activity positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of protein serine/threonine kinase activity positive regulation of proteolysis involved in protein catabolic process positive regulation of proteolysis positive regulation of response to endoplasmic reticulum stress positive regulation of response to stimulus positive regulation of signal transduction positive regulation of signaling positive regulation of small molecule metabolic process positive regulation of smooth muscle cell differentiation positive regulation of sterol transport positive regulation of transcription by RNA polymerase II positive regulation of transferase activity positive regulation of transport positive regulation of ubiquitin-dependent protein catabolic process positive regulation of vasculature development post-translational protein modification primary metabolic process promoter-specific chromatin binding proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein acetylation protein acylation protein binding protein catabolic process protein deacetylation protein deacylation protein decrotonylase activity protein depropionylation protein destabilization protein domain specific binding protein kinase binding protein lysine deacetylase activity protein metabolic process protein modification by small protein conjugation or removal protein modification by small protein conjugation protein modification process protein ubiquitination protein-DNA complex organization protein-DNA complex protein-containing complex binding protein-containing complex organization protein-containing complex protein-propionyllysine depropionylase activity proteolysis involved in protein catabolic process proteolysis purine nucleotide binding pyrimidine dimer repair by nucleotide-excision repair pyrimidine dimer repair rDNA heterochromatin formation rDNA heterochromatin regulation of DNA damage response, signal transduction by p53 class mediator regulation of DNA metabolic process regulation of DNA repair regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of MHC class II biosynthetic process regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of TOR signaling regulation of adaptive immune response regulation of adipose tissue development regulation of anatomical structure morphogenesis regulation of androgen receptor signaling pathway regulation of angiogenesis regulation of apoptotic process regulation of apoptotic signaling pathway regulation of attachment of mitotic spindle microtubules to kinetochore regulation of attachment of spindle microtubules to kinetochore regulation of autophagy regulation of bile acid biosynthetic process regulation of bile acid metabolic process regulation of biological process regulation of biological quality regulation of biosynthetic process regulation of blood vessel endothelial cell migration regulation of brown fat cell differentiation regulation of cAMP-dependent protein kinase activity regulation of canonical NF-kappaB signal transduction regulation of carbohydrate biosynthetic process regulation of carbohydrate metabolic process regulation of catabolic process regulation of catalytic activity regulation of cell communication regulation of cell cycle process regulation of cell cycle regulation of cell differentiation regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular catabolic process regulation of cellular component organization regulation of cellular ketone metabolic process regulation of cellular metabolic process regulation of cellular process regulation of cellular response to growth factor stimulus regulation of cellular response to heat regulation of cellular response to insulin stimulus regulation of cellular response to stress regulation of cellular response to testosterone stimulus regulation of cellular response to transforming growth factor beta stimulus regulation of cellular senescence regulation of centrosome cycle regulation of centrosome duplication regulation of cholesterol efflux regulation of cholesterol transport regulation of chromosome organization regulation of chromosome segregation regulation of cysteine-type endopeptidase activity regulation of cytokine production involved in immune response regulation of cytokine production regulation of deoxyribonuclease activity regulation of developmental process regulation of double-strand break repair regulation of endodeoxyribonuclease activity regulation of endopeptidase activity regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of endothelial cell migration regulation of endothelial cell proliferation regulation of epithelial cell migration regulation of epithelial cell proliferation regulation of fat cell differentiation regulation of fatty acid biosynthetic process regulation of fatty acid metabolic process regulation of gene expression regulation of gluconeogenesis regulation of glucose metabolic process regulation of hippo signaling regulation of hydrolase activity regulation of immune effector process regulation of immune response regulation of immune system process regulation of insulin receptor signaling pathway regulation of intracellular signal transduction regulation of intracellular steroid hormone receptor signaling pathway regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of intrinsic apoptotic signaling pathway regulation of kinase activity regulation of leukocyte apoptotic process regulation of lipid biosynthetic process regulation of lipid localization regulation of lipid metabolic process regulation of lipid storage regulation of lipid transport regulation of localization regulation of locomotion regulation of macroautophagy regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of macrophage apoptotic process regulation of macrophage cytokine production regulation of metabolic process regulation of metaphase plate congression regulation of microtubule-based process regulation of mitotic cell cycle regulation of mitotic sister chromatid segregation regulation of molecular function regulation of multicellular organismal development regulation of multicellular organismal process regulation of muscle cell apoptotic process regulation of muscle cell differentiation regulation of myeloid cell apoptotic process regulation of neuron apoptotic process regulation of nitrogen compound metabolic process regulation of nuclease activity regulation of nucleobase-containing compound metabolic process regulation of organelle organization regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of peptidase activity regulation of peptidyl-lysine acetylation regulation of peroxisome proliferator activated receptor signaling pathway regulation of phosphate metabolic process regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of phosphorus metabolic process regulation of phosphorylation regulation of primary metabolic process regulation of production of molecular mediator of immune response regulation of programmed cell death regulation of prostaglandin biosynthetic process regulation of proteasomal protein catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein acetylation regulation of protein catabolic process regulation of protein kinase activity regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of protein serine/threonine kinase activity regulation of protein stability regulation of proteolysis involved in protein catabolic process regulation of proteolysis regulation of response to endoplasmic reticulum stress regulation of response to stimulus regulation of response to stress regulation of signal transduction by p53 class mediator regulation of signal transduction regulation of signaling regulation of sister chromatid segregation regulation of small molecule metabolic process regulation of smooth muscle cell apoptotic process regulation of smooth muscle cell differentiation regulation of steroid biosynthetic process regulation of steroid metabolic process regulation of sterol transport regulation of transcription by RNA polymerase II regulation of transcription by glucose regulation of transferase activity regulation of transforming growth factor beta receptor signaling pathway regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of transport regulation of triglyceride biosynthetic process regulation of triglyceride metabolic process regulation of ubiquitin-dependent protein catabolic process regulation of unsaturated fatty acid biosynthetic process regulation of vasculature development reproductive process response to UV response to abiotic stimulus response to chemical response to cytokine response to decreased oxygen levels response to endogenous stimulus response to external stimulus response to extracellular stimulus response to hormone response to hydrogen peroxide response to hypoxia response to inorganic substance response to insulin response to ionizing radiation response to leptin response to leukemia inhibitory factor response to light stimulus response to nitrogen compound response to nutrient levels response to organic substance response to organonitrogen compound response to oxidative stress response to oxygen levels response to oxygen-containing compound response to peptide hormone response to peptide response to radiation response to reactive oxygen species response to starvation response to stimulus response to stress response to tumor necrosis factor rhythmic process sequence-specific DNA binding sequence-specific double-stranded DNA binding signal transduction by p53 class mediator signal transduction single strand break repair small molecule binding spermatogenesis sterol homeostasis stress-induced premature senescence transcription cis-regulatory region binding transcription coactivator activity transcription coregulator activity transcription corepressor activity transcription factor binding transcription regulator activity transcription regulatory region nucleic acid binding transferase activity transferase complex transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor superfamily signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway triglyceride homeostasis triglyceride metabolic process triglyceride mobilization ubiquitin-dependent protein catabolic process white fat cell differentiation	GO:0000012 GO:0000122 GO:0000166 GO:0000183 GO:0000302 GO:0000720 GO:0000731 GO:0000785 GO:0000791 GO:0000792 GO:0000976 GO:0000977 GO:0000978 GO:0000987 GO:0001067 GO:0001525 GO:0001542 GO:0001650 GO:0001666 GO:0001678 GO:0001817 GO:0001819 GO:0001932 GO:0001934 GO:0001936 GO:0001938 GO:0002039 GO:0002521 GO:0002573 GO:0002682 GO:0002684 GO:0002697 GO:0002699 GO:0002700 GO:0002702 GO:0002718 GO:0002720 GO:0002819 GO:0002821 GO:0003006 GO:0003674 GO:0003676 GO:0003677 GO:0003682 GO:0003690 GO:0003712 GO:0003713 GO:0003714 GO:0003824 GO:0003950 GO:0004407 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005635 GO:0005637 GO:0005654 GO:0005677 GO:0005730 GO:0005737 GO:0005739 GO:0005829 GO:0006109 GO:0006111 GO:0006139 GO:0006259 GO:0006281 GO:0006282 GO:0006289 GO:0006290 GO:0006325 GO:0006338 GO:0006346 GO:0006355 GO:0006357 GO:0006473 GO:0006476 GO:0006508 GO:0006511 GO:0006629 GO:0006638 GO:0006639 GO:0006641 GO:0006642 GO:0006725 GO:0006807 GO:0006950 GO:0006974 GO:0006979 GO:0007154 GO:0007165 GO:0007166 GO:0007167 GO:0007178 GO:0007179 GO:0007276 GO:0007283 GO:0007346 GO:0007517 GO:0007623 GO:0008047 GO:0008134 GO:0008150 GO:0008152 GO:0008284 GO:0008630 GO:0009056 GO:0009057 GO:0009058 GO:0009059 GO:0009267 GO:0009314 GO:0009411 GO:0009416 GO:0009605 GO:0009628 GO:0009719 GO:0009725 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009894 GO:0009896 GO:0009966 GO:0009967 GO:0009968 GO:0009987 GO:0009991 GO:0010033 GO:0010035 GO:0010212 GO:0010243 GO:0010468 GO:0010498 GO:0010506 GO:0010508 GO:0010556 GO:0010557 GO:0010558 GO:0010562 GO:0010563 GO:0010564 GO:0010565 GO:0010594 GO:0010595 GO:0010604 GO:0010605 GO:0010628 GO:0010629 GO:0010632 GO:0010634 GO:0010646 GO:0010647 GO:0010648 GO:0010660 GO:0010824 GO:0010866 GO:0010868 GO:0010874 GO:0010875 GO:0010883 GO:0010906 GO:0010907 GO:0010935 GO:0010948 GO:0010950 GO:0010952 GO:0016020 GO:0016043 GO:0016239 GO:0016241 GO:0016410 GO:0016567 GO:0016604 GO:0016605 GO:0016740 GO:0016746 GO:0016747 GO:0016757 GO:0016763 GO:0016787 GO:0016810 GO:0016811 GO:0016922 GO:0017015 GO:0017076 GO:0017136 GO:0018130 GO:0018193 GO:0018205 GO:0018394 GO:0019213 GO:0019215 GO:0019216 GO:0019217 GO:0019218 GO:0019219 GO:0019220 GO:0019221 GO:0019222 GO:0019438 GO:0019538 GO:0019725 GO:0019866 GO:0019899 GO:0019900 GO:0019901 GO:0019904 GO:0019941 GO:0022414 GO:0022602 GO:0022603 GO:0023051 GO:0023056 GO:0023057 GO:0030099 GO:0030154 GO:0030162 GO:0030163 GO:0030225 GO:0030234 GO:0030334 GO:0030335 GO:0030512 GO:0030554 GO:0030728 GO:0031078 GO:0031090 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031329 GO:0031331 GO:0031392 GO:0031393 GO:0031399 GO:0031400 GO:0031401 GO:0031507 GO:0031519 GO:0031647 GO:0031648 GO:0031667 GO:0031668 GO:0031669 GO:0031965 GO:0031967 GO:0031975 GO:0032006 GO:0032007 GO:0032041 GO:0032069 GO:0032070 GO:0032071 GO:0032088 GO:0032129 GO:0032368 GO:0032370 GO:0032371 GO:0032373 GO:0032374 GO:0032376 GO:0032434 GO:0032436 GO:0032446 GO:0032501 GO:0032502 GO:0032868 GO:0032879 GO:0032886 GO:0032922 GO:0032991 GO:0032993 GO:0033032 GO:0033034 GO:0033043 GO:0033044 GO:0033045 GO:0033047 GO:0033143 GO:0033144 GO:0033210 GO:0033500 GO:0033553 GO:0033554 GO:0033558 GO:0033674 GO:0034097 GO:0034391 GO:0034599 GO:0034612 GO:0034614 GO:0034641 GO:0034644 GO:0034654 GO:0034708 GO:0034739 GO:0034979 GO:0035097 GO:0035098 GO:0035330 GO:0035331 GO:0035356 GO:0035358 GO:0035556 GO:0035601 GO:0036094 GO:0036211 GO:0036293 GO:0036294 GO:0040012 GO:0040017 GO:0040029 GO:0042127 GO:0042149 GO:0042176 GO:0042221 GO:0042304 GO:0042325 GO:0042326 GO:0042327 GO:0042393 GO:0042542 GO:0042592 GO:0042593 GO:0042594 GO:0042595 GO:0042632 GO:0042771 GO:0042802 GO:0042981 GO:0043065 GO:0043066 GO:0043067 GO:0043068 GO:0043069 GO:0043085 GO:0043122 GO:0043124 GO:0043161 GO:0043167 GO:0043168 GO:0043169 GO:0043170 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043255 GO:0043398 GO:0043412 GO:0043425 GO:0043433 GO:0043434 GO:0043516 GO:0043518 GO:0043523 GO:0043524 GO:0043535 GO:0043536 GO:0043543 GO:0043549 GO:0043565 GO:0043632 GO:0043687 GO:0043933 GO:0044092 GO:0044093 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0044271 GO:0044321 GO:0044877 GO:0045346 GO:0045348 GO:0045444 GO:0045595 GO:0045596 GO:0045597 GO:0045598 GO:0045599 GO:0045717 GO:0045722 GO:0045732 GO:0045739 GO:0045765 GO:0045766 GO:0045786 GO:0045814 GO:0045833 GO:0045859 GO:0045860 GO:0045862 GO:0045892 GO:0045893 GO:0045913 GO:0045922 GO:0045934 GO:0045935 GO:0045936 GO:0045937 GO:0045944 GO:0046015 GO:0046483 GO:0046486 GO:0046605 GO:0046626 GO:0046628 GO:0046872 GO:0046890 GO:0046969 GO:0046970 GO:0048232 GO:0048511 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0048609 GO:0048646 GO:0048856 GO:0048869 GO:0048871 GO:0048878 GO:0050678 GO:0050679 GO:0050776 GO:0050778 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0050810 GO:0050872 GO:0050896 GO:0051019 GO:0051049 GO:0051050 GO:0051052 GO:0051054 GO:0051055 GO:0051090 GO:0051093 GO:0051094 GO:0051128 GO:0051147 GO:0051149 GO:0051150 GO:0051152 GO:0051171 GO:0051172 GO:0051173 GO:0051174 GO:0051179 GO:0051235 GO:0051239 GO:0051240 GO:0051246 GO:0051247 GO:0051248 GO:0051252 GO:0051253 GO:0051254 GO:0051287 GO:0051336 GO:0051338 GO:0051345 GO:0051347 GO:0051603 GO:0051640 GO:0051647 GO:0051651 GO:0051657 GO:0051658 GO:0051716 GO:0051726 GO:0051896 GO:0051897 GO:0051898 GO:0051983 GO:0051985 GO:0051986 GO:0051988 GO:0052547 GO:0052548 GO:0055082 GO:0055088 GO:0055089 GO:0055090 GO:0055092 GO:0060255 GO:0060765 GO:0060766 GO:0060907 GO:0061061 GO:0061081 GO:0061136 GO:0061629 GO:0061773 GO:0062012 GO:0062013 GO:0062014 GO:0062197 GO:0065007 GO:0065008 GO:0065009 GO:0070301 GO:0070328 GO:0070403 GO:0070482 GO:0070647 GO:0070828 GO:0070857 GO:0070887 GO:0070914 GO:0071214 GO:0071310 GO:0071345 GO:0071356 GO:0071453 GO:0071456 GO:0071478 GO:0071479 GO:0071482 GO:0071496 GO:0071704 GO:0071824 GO:0071840 GO:0071897 GO:0071900 GO:0071902 GO:0072331 GO:0072332 GO:0080090 GO:0080134 GO:0080135 GO:0090092 GO:0090101 GO:0090207 GO:0090209 GO:0090235 GO:0090287 GO:0090304 GO:0090335 GO:0090398 GO:0090400 GO:0097009 GO:0097159 GO:0097190 GO:0097193 GO:0097372 GO:0098732 GO:0098772 GO:0104004 GO:0106230 GO:0106231 GO:0110165 GO:0140096 GO:0140110 GO:0140297 GO:0140513 GO:0140677 GO:0140718 GO:0140765 GO:0140861 GO:0140937 GO:0140993 GO:0141050 GO:0141051 GO:0141091 GO:0160008 GO:0160009 GO:0160011 GO:0160012 GO:0170012 GO:1900034 GO:1900076 GO:1900078 GO:1901265 GO:1901342 GO:1901360 GO:1901362 GO:1901363 GO:1901564 GO:1901565 GO:1901575 GO:1901576 GO:1901652 GO:1901698 GO:1901700 GO:1901701 GO:1901796 GO:1901797 GO:1901800 GO:1901983 GO:1901984 GO:1902165 GO:1902166 GO:1902175 GO:1902176 GO:1902229 GO:1902230 GO:1902235 GO:1902237 GO:1902253 GO:1902254 GO:1902423 GO:1902424 GO:1902494 GO:1902531 GO:1902532 GO:1902533 GO:1902679 GO:1902680 GO:1903050 GO:1903052 GO:1903844 GO:1904018 GO:1904177 GO:1904179 GO:1904251 GO:1905897 GO:1905898 GO:1905952 GO:1905954 GO:1990234 GO:1990254 GO:1990404 GO:1990823 GO:1990830 GO:1990837 GO:1990841 GO:2000026 GO:2000058 GO:2000060 GO:2000106 GO:2000108 GO:2000109 GO:2000111 GO:2000116 GO:2000145 GO:2000147 GO:2000479 GO:2000481 GO:2000654 GO:2000655 GO:2000756 GO:2000757 GO:2000772 GO:2000773 GO:2000774 GO:2000779 GO:2000781 GO:2001056 GO:2001141 GO:2001233 GO:2001234 GO:2001235 GO:2001242 GO:2001243 GO:2001244 GO:2001279
55247	nei like DNA glycosylase 3	NEIL3 Aliases: FLJ10858 FPG2 ZGRF3 hFPG2 hNEI3 zinc finger, GRF-type containing 3	Homo sapiens (human)	9606			DNA N-glycosylase activity DNA binding DNA damage response DNA metabolic process DNA modification DNA repair DNA secondary structure binding DNA-(apurinic or apyrimidinic site) endonuclease activity MCM complex binding base-excision repair, AP site formation base-excision repair binding biological_process bubble DNA binding carbon-oxygen lyase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity cation binding cellular anatomical entity cellular aromatic compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular response to stimulus cellular response to stress cellular_component chromosome class I DNA-(apurinic or apyrimidinic site) endonuclease activity damaged DNA binding depurination double-stranded DNA binding heterocycle metabolic process hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing N-glycosyl compounds hydrolase activity interstrand cross-link repair intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle ion binding lyase activity macromolecule metabolic process macromolecule modification membrane-bounded organelle metabolic process metal ion binding molecular_function nitrogen compound metabolic process non-membrane-bounded organelle nucleic acid binding nucleic acid metabolic process nucleobase-containing compound metabolic process nucleoplasm nucleus organelle organic cyclic compound binding organic cyclic compound metabolic process organic substance metabolic process primary metabolic process protein-containing complex binding response to stimulus response to stress single strand break repair single-stranded DNA binding transition metal ion binding zinc ion binding	GO:0000012 GO:0000217 GO:0000405 GO:0003674 GO:0003676 GO:0003677 GO:0003684 GO:0003690 GO:0003697 GO:0003824 GO:0003906 GO:0005488 GO:0005575 GO:0005634 GO:0005654 GO:0005694 GO:0006139 GO:0006259 GO:0006281 GO:0006284 GO:0006285 GO:0006304 GO:0006725 GO:0006807 GO:0006950 GO:0006974 GO:0008150 GO:0008152 GO:0008270 GO:0009987 GO:0016787 GO:0016798 GO:0016799 GO:0016829 GO:0016835 GO:0019104 GO:0033554 GO:0034641 GO:0036297 GO:0043167 GO:0043169 GO:0043170 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043412 GO:0044237 GO:0044238 GO:0044877 GO:0045007 GO:0046483 GO:0046872 GO:0046914 GO:0050896 GO:0051716 GO:0071704 GO:0090304 GO:0097159 GO:0110165 GO:0140078 GO:0140097 GO:0140640 GO:1901360 GO:1904931
54840	aprataxin	APTX Aliases: AOA AOA1 EAOH EOAHA FLJ20157	Homo sapiens (human)	9606	ataxia with oculomotor apraxia type 1 olivopontocerebellar atrophy	DOID:0050754 DOID:14784	5'-3' DNA exonuclease activity 5'-3' exonuclease activity DNA 5'-adenosine monophosphate hydrolase activity DNA binding DNA damage response DNA exonuclease activity, producing 5'-phosphomonoesters DNA exonuclease activity DNA ligation DNA metabolic process DNA nuclease activity DNA repair DNA-3'-diphospho-5'-guanosine diphosphatase RNA binding binding biological regulation biological_process catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity cation binding cellular anatomical entity cellular aromatic compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular response to stimulus cellular response to stress cellular_component chromatin binding chromatin cytoplasm damaged DNA binding double-stranded DNA binding double-stranded RNA binding exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters exonuclease activity heterocycle metabolic process hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides hydrolase activity, acting on ester bonds hydrolase activity intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle ion binding macromolecule metabolic process membrane-bounded organelle metabolic process metal ion binding mismatched DNA binding molecular_function nitrogen compound metabolic process non-membrane-bounded organelle nuclease activity nucleic acid binding nucleic acid metabolic process nucleobase-containing compound metabolic process nucleolus nucleoplasm nucleus organelle organic cyclic compound binding organic cyclic compound metabolic process organic substance metabolic process phosphatase activity phosphoglycolate phosphatase activity phosphoprotein binding phosphoric ester hydrolase activity polynucleotide 3'-phosphatase activity primary metabolic process protein binding protein-DNA complex protein-containing complex binding protein-containing complex pyrophosphatase activity regulation of biological quality regulation of protein stability response to stimulus response to stress single strand break repair single-strand break-containing DNA binding single-stranded DNA binding transition metal ion binding zinc ion binding	GO:0000012 GO:0000785 GO:0003674 GO:0003676 GO:0003677 GO:0003682 GO:0003684 GO:0003690 GO:0003697 GO:0003723 GO:0003725 GO:0003824 GO:0004518 GO:0004527 GO:0004529 GO:0004536 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0006139 GO:0006259 GO:0006266 GO:0006281 GO:0006725 GO:0006807 GO:0006950 GO:0006974 GO:0008150 GO:0008152 GO:0008270 GO:0008409 GO:0008967 GO:0009987 GO:0016462 GO:0016787 GO:0016788 GO:0016791 GO:0016796 GO:0016817 GO:0016818 GO:0016895 GO:0030983 GO:0031647 GO:0032991 GO:0032993 GO:0033554 GO:0033699 GO:0034641 GO:0035312 GO:0042578 GO:0043167 GO:0043169 GO:0043170 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0044237 GO:0044238 GO:0044877 GO:0046403 GO:0046483 GO:0046872 GO:0046914 GO:0050896 GO:0051219 GO:0051716 GO:0065007 GO:0065008 GO:0071704 GO:0090304 GO:0097159 GO:0110165 GO:0120108 GO:0140097 GO:0140640 GO:1901360 GO:1990165

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