GlyCosmos Portal

GlyCosmos Genes

Integrated list of glycan-related genes extracted KEGG GENES Database, UniProt, GlycoGene Database (GGDB), Plant GARDEN and FlyGlycoDB. Glycan-related genes including glycosyltransferase, hydrolase activity (acting on glycosyl bonds), carbohydrate metabolic process, etc .

Source	Last Updated
FlyGlycoDB	March 25, 2024
GlycoGene Database (GGDB)	January 26, 2018
KEGG GENES Database	September 20, 2023
Plant GARDEN	May 28, 2020
UniProt	October 29, 2024

Selecting the function you want to look up from the categories displays a list narrowed down to glycan-related genes with that function (Gene Ontology).

Catalytic activity

glycosyltransferase activity

hydrolase activity, acting on glycosyl bonds

Binding

carbohydrate binding

Response to carbohydrate

Primary metabolic process

Displaying entries **1 - 25** of **9988** in total

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Gene ID	Gene Name	Gene Symbol	Organism	Taxonomy ID ▼	Disease Ontology	Disease Ontology ID	Gene Ontology	Gene Ontology ID
10082	glypican 6	GPC6 Aliases: glypican proteoglycan 6	Homo sapiens (human)	9606	Alzheimer's disease 10 Alzheimer's disease 11 Alzheimer's disease 12 Alzheimer's disease 13 Alzheimer's disease 14 Alzheimer's disease 15 Alzheimer's disease 1 Alzheimer's disease 2 Alzheimer's disease 5 Alzheimer's disease 6 Alzheimer's disease 7 Alzheimer's disease 8 Alzheimer's disease Pick's disease Reye syndrome Simpson-Golabi-Behmel syndrome type 1 atrial heart septal defect 1 atrial heart septal defect 2 atrial heart septal defect 3 atrial heart septal defect 4 atrial heart septal defect 5 atrial heart septal defect 6 atrial heart septal defect 7 atrial heart septal defect 8 atrial heart septal defect 9 atrial heart septal defect attention deficit hyperactivity disorder blepharophimosis breast cancer breast carcinoma cancer cardiovascular system disease cavernous hemangioma cerebral degeneration chorioangioma colorectal cancer colorectal carcinoma craniosynostosis cryptorchidism degenerative disc disease dissociative disorder embryoma enterocele familial retinoblastoma glomus tumor heart disease hemangioma histiocytoid hemangioma intellectual disability intramuscular hemangioma large intestine cancer learning disability lymphangioma melanoma neurotic disorder omodysplasia 1 omodysplasia omphalocele osteoporosis ovarian cancer ovarian carcinoma patent foramen ovale pterygium reflex sympathetic dystrophy retinoblastoma schizophrenia skin melanoma trilateral retinoblastoma umbilical hernia ventricular septal defect	DOID:0002116 DOID:0060248 DOID:0060288 DOID:0060321 DOID:0060327 DOID:0080199 DOID:0080348 DOID:0080844 DOID:0110035 DOID:0110037 DOID:0110038 DOID:0110039 DOID:0110041 DOID:0110043 DOID:0110044 DOID:0110045 DOID:0110046 DOID:0110047 DOID:0110048 DOID:0110106 DOID:0110107 DOID:0110108 DOID:0110109 DOID:0110110 DOID:0110111 DOID:0110112 DOID:0110113 DOID:0110114 DOID:10348 DOID:1059 DOID:10652 DOID:10935 DOID:1094 DOID:11383 DOID:114 DOID:11476 DOID:11870 DOID:1283 DOID:1287 DOID:13620 DOID:1443 DOID:14525 DOID:1475 DOID:1612 DOID:162 DOID:1657 DOID:1811 DOID:1882 DOID:1909 DOID:2340 DOID:2394 DOID:2431 DOID:255 DOID:277 DOID:3459 DOID:4001 DOID:4647 DOID:4648 DOID:468 DOID:474 DOID:4766 DOID:483 DOID:4964 DOID:5419 DOID:5672 DOID:768 DOID:8923 DOID:8927 DOID:90 DOID:9256	Golgi lumen binding biological regulation biological_process cell junction cell migration cell motility cell surface cellular anatomical entity cellular process cellular_component collagen-containing extracellular matrix coreceptor activity external encapsulating structure extracellular matrix extracellular region glutamatergic synapse intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle lysosomal lumen membrane-bounded organelle membrane-enclosed lumen membrane molecular transducer activity molecular_function nucleus organelle lumen organelle plasma membrane protein binding regulation of biological process regulation of biological quality regulation of cell communication regulation of cellular localization regulation of cellular process regulation of localization regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to cell periphery regulation of protein localization to membrane regulation of protein localization to synapse regulation of protein localization regulation of receptor localization to synapse regulation of response to stimulus regulation of signal transduction regulation of signaling side of membrane signaling receptor activity synapse vacuolar lumen	GO:0003674 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005634 GO:0005775 GO:0005796 GO:0005886 GO:0008150 GO:0009966 GO:0009986 GO:0009987 GO:0010646 GO:0015026 GO:0016020 GO:0016477 GO:0023051 GO:0030054 GO:0030312 GO:0031012 GO:0031974 GO:0032879 GO:0032880 GO:0038023 GO:0043202 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0045202 GO:0048583 GO:0048870 GO:0050789 GO:0050794 GO:0060089 GO:0060341 GO:0062023 GO:0065007 GO:0065008 GO:0070013 GO:0098552 GO:0098696 GO:0098978 GO:0110165 GO:1902473 GO:1902683 GO:1904375 GO:1905475
7087	intercellular adhesion molecule 5	ICAM5 Aliases: TLN telencephalin	Homo sapiens (human)	9606	adenoid cystic carcinoma breast cancer cancer chronic fatigue syndrome colorectal cancer colorectal carcinoma dermatitis embryoma encephalitis encephalomyelitis fragile X syndrome head and neck cancer hematopoietic system disease large intestine cancer multiple sclerosis myelitis parapsoriasis prostate cancer prostate carcinoma psoriasis pustulosis of palm and sole salivary gland adenoid cystic carcinoma squamous cell carcinoma systemic lupus erythematosus tongue squamous cell carcinoma	DOID:0050865 DOID:0080199 DOID:0080202 DOID:10283 DOID:10286 DOID:11934 DOID:14261 DOID:1612 DOID:162 DOID:1749 DOID:2377 DOID:2723 DOID:322 DOID:4398 DOID:4766 DOID:4866 DOID:5672 DOID:640 DOID:74 DOID:8544 DOID:8893 DOID:9074 DOID:9088 DOID:9256 DOID:9588	binding biological regulation biological_process cell adhesion molecule binding cell adhesion cell junction cell-cell adhesion cellular anatomical entity cellular process cellular_component endocytosis establishment of localization glutamatergic synapse import into cell integrin binding localization membrane molecular_function phagocytosis plasma membrane postsynapse protein binding protein-containing complex binding regulation of biological process regulation of cell junction assembly regulation of cellular component biogenesis regulation of cellular component organization regulation of cellular process regulation of synapse assembly regulation of synapse organization signaling receptor binding synapse transport vesicle-mediated transport	GO:0003674 GO:0005102 GO:0005178 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0006810 GO:0006897 GO:0006909 GO:0007155 GO:0008150 GO:0009987 GO:0016020 GO:0016192 GO:0030054 GO:0044087 GO:0044877 GO:0045202 GO:0050789 GO:0050794 GO:0050807 GO:0050839 GO:0051128 GO:0051179 GO:0051234 GO:0051963 GO:0065007 GO:0098609 GO:0098657 GO:0098794 GO:0098978 GO:0110165 GO:1901888
3716	Janus kinase 1	JAK1	Homo sapiens (human)	9606			ATP binding CCR chemokine receptor binding CCR5 chemokine receptor binding CD4-positive or CD8-positive, alpha-beta T cell lineage commitment CD4-positive, alpha-beta T cell lineage commitment G protein-coupled receptor binding T cell lineage commitment T-helper 17 cell lineage commitment T-helper cell lineage commitment adenyl nucleotide binding adenyl ribonucleotide binding alpha-beta T cell lineage commitment anchoring junction anion binding binding biological process involved in interspecies interaction between organisms biological regulation biological_process carbohydrate derivative binding catalytic activity, acting on a protein catalytic activity cation binding cell differentiation cell fate commitment cell junction cell surface receptor signaling pathway cell-substrate junction cellular anatomical entity cellular developmental process cellular localization cellular macromolecule localization cellular metabolic process cellular process cellular response to virus cellular_component chemokine receptor binding cytokine receptor binding cytokine-mediated signaling pathway cytoplasm cytoplasmic side of membrane cytoplasmic side of plasma membrane cytoplasmic vesicle cytoskeleton cytosol developmental process endosome enzyme binding enzyme-linked receptor protein signaling pathway extrinsic component of cytoplasmic side of plasma membrane extrinsic component of membrane extrinsic component of plasma membrane focal adhesion growth hormone receptor binding growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway heterocyclic compound binding hormone receptor binding interferon-mediated signaling pathway interleukin-10-mediated signaling pathway interleukin-11-mediated signaling pathway interleukin-15-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-4-mediated signaling pathway interleukin-6-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle intracellular signal transduction intracellular vesicle ion binding kinase activity localization macromolecule localization macromolecule metabolic process macromolecule modification membrane-bounded organelle membrane metabolic process metal ion binding molecular_function nitrogen compound metabolic process non-membrane spanning protein tyrosine kinase activity non-membrane-bounded organelle nucleoside phosphate binding nucleotide binding nucleus organelle organic cyclic compound binding organic substance metabolic process organonitrogen compound metabolic process phosphatase binding phosphate-containing compound metabolic process phosphorus metabolic process phosphorylation phosphotransferase activity, alcohol group as acceptor plasma membrane positive regulation of angiogenesis positive regulation of biological process positive regulation of cell adhesion positive regulation of cell-cell adhesion positive regulation of cellular process positive regulation of developmental process positive regulation of homotypic cell-cell adhesion positive regulation of multicellular organismal process positive regulation of protein localization to nucleus positive regulation of protein localization positive regulation of sprouting angiogenesis positive regulation of vasculature development primary metabolic process protein binding protein kinase activity protein localization to cell junction protein localization to cell-cell junction protein localization protein metabolic process protein modification process protein phosphatase binding protein phosphorylation protein tyrosine kinase activity purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding receptor signaling pathway via JAK-STAT receptor signaling pathway via STAT regulation of anatomical structure morphogenesis regulation of angiogenesis regulation of biological process regulation of cell adhesion regulation of cell-cell adhesion regulation of cellular localization regulation of cellular process regulation of developmental process regulation of homotypic cell-cell adhesion regulation of localization regulation of multicellular organismal development regulation of multicellular organismal process regulation of protein localization to nucleus regulation of protein localization regulation of sprouting angiogenesis regulation of vasculature development response to antibiotic response to biotic stimulus response to chemical response to external biotic stimulus response to external stimulus response to other organism response to stimulus response to virus ribonucleotide binding side of membrane signal transduction signaling receptor binding small molecule binding transferase activity, transferring phosphorus-containing groups transferase activity transmembrane receptor protein tyrosine kinase signaling pathway type I interferon-mediated signaling pathway type II interferon-mediated signaling pathway type III interferon-mediated signaling pathway ubiquitin protein ligase binding ubiquitin-like protein ligase binding vesicle	GO:0000166 GO:0001664 GO:0002295 GO:0002360 GO:0002363 GO:0003674 GO:0003824 GO:0004672 GO:0004713 GO:0004715 GO:0005102 GO:0005126 GO:0005131 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005634 GO:0005737 GO:0005768 GO:0005829 GO:0005856 GO:0005886 GO:0005925 GO:0006468 GO:0006793 GO:0006796 GO:0006807 GO:0007165 GO:0007166 GO:0007167 GO:0007169 GO:0007259 GO:0008104 GO:0008150 GO:0008152 GO:0009605 GO:0009607 GO:0009615 GO:0009898 GO:0009987 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0016773 GO:0017076 GO:0019221 GO:0019538 GO:0019897 GO:0019898 GO:0019899 GO:0019902 GO:0019903 GO:0022407 GO:0022409 GO:0022603 GO:0030054 GO:0030055 GO:0030154 GO:0030155 GO:0030554 GO:0031234 GO:0031410 GO:0031625 GO:0031730 GO:0031982 GO:0032502 GO:0032553 GO:0032555 GO:0032559 GO:0032879 GO:0032880 GO:0033036 GO:0034110 GO:0034112 GO:0035556 GO:0035639 GO:0035723 GO:0035771 GO:0036094 GO:0036211 GO:0038110 GO:0038111 GO:0038113 GO:0038154 GO:0038196 GO:0042221 GO:0042379 GO:0043167 GO:0043168 GO:0043169 GO:0043170 GO:0043207 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043369 GO:0043373 GO:0043412 GO:0044237 GO:0044238 GO:0044389 GO:0044419 GO:0045165 GO:0045765 GO:0045766 GO:0045785 GO:0046677 GO:0046872 GO:0048020 GO:0048518 GO:0048522 GO:0048869 GO:0050789 GO:0050793 GO:0050794 GO:0050896 GO:0051094 GO:0051179 GO:0051239 GO:0051240 GO:0051427 GO:0051641 GO:0051707 GO:0060333 GO:0060337 GO:0060341 GO:0060396 GO:0060397 GO:0065007 GO:0070102 GO:0070161 GO:0070727 GO:0071704 GO:0072540 GO:0097159 GO:0097367 GO:0097696 GO:0097708 GO:0098552 GO:0098562 GO:0098586 GO:0110165 GO:0140096 GO:0140105 GO:0140888 GO:0150105 GO:1900180 GO:1900182 GO:1901265 GO:1901342 GO:1901363 GO:1901564 GO:1902414 GO:1903670 GO:1903672 GO:1903829 GO:1904018 GO:2000026
5378	PMS1 homolog 1, mismatch repair system component	PMS1	Homo sapiens (human)	9606			ATP binding ATP hydrolysis activity ATP-dependent DNA damage sensor activity ATP-dependent activity, acting on DNA ATP-dependent activity DNA binding DNA damage response DNA damage sensor activity DNA metabolic process DNA repair MutLalpha complex adenyl nucleotide binding adenyl ribonucleotide binding anion binding binding biological_process carbohydrate derivative binding catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity cellular anatomical entity cellular aromatic compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process cellular process cellular response to stimulus cellular response to stress cellular_component double-stranded DNA binding enzyme binding heterocycle metabolic process heterocyclic compound binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides hydrolase activity intracellular membrane-bounded organelle intracellular organelle ion binding macromolecule metabolic process membrane-bounded organelle metabolic process mismatch repair complex mismatch repair mismatched DNA binding molecular_function nitrogen compound metabolic process nuclear protein-containing complex nucleic acid binding nucleic acid metabolic process nucleobase-containing compound metabolic process nucleoside phosphate binding nucleotide binding nucleus organelle organic cyclic compound binding organic cyclic compound metabolic process organic substance metabolic process primary metabolic process protein binding protein-containing complex purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding pyrophosphatase activity response to chemical response to stimulus response to stress response to xenobiotic stimulus ribonucleoside triphosphate phosphatase activity ribonucleotide binding small molecule binding small molecule sensor activity	GO:0000166 GO:0003674 GO:0003676 GO:0003677 GO:0003690 GO:0003824 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005634 GO:0006139 GO:0006259 GO:0006281 GO:0006298 GO:0006725 GO:0006807 GO:0006950 GO:0006974 GO:0008094 GO:0008150 GO:0008152 GO:0009410 GO:0009987 GO:0016462 GO:0016787 GO:0016817 GO:0016818 GO:0016887 GO:0017076 GO:0017111 GO:0019899 GO:0030554 GO:0030983 GO:0032300 GO:0032389 GO:0032553 GO:0032555 GO:0032559 GO:0032991 GO:0033554 GO:0034641 GO:0035639 GO:0036094 GO:0042221 GO:0043167 GO:0043168 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0044237 GO:0044238 GO:0046483 GO:0050896 GO:0051716 GO:0071704 GO:0090304 GO:0097159 GO:0097367 GO:0110165 GO:0140097 GO:0140299 GO:0140513 GO:0140612 GO:0140640 GO:0140657 GO:0140664 GO:1901265 GO:1901360 GO:1901363
1280	collagen type II alpha 1 chain	COL2A1	Homo sapiens (human)	9606			MHC class II protein binding MHC protein binding anatomical structure development anatomical structure formation involved in morphogenesis anatomical structure homeostasis anatomical structure morphogenesis animal organ development animal organ morphogenesis anterior head development apoptotic signaling pathway basement membrane binding biological regulation biological_process carbohydrate derivative binding carbohydrate derivative metabolic process cartilage condensation cartilage development involved in endochondral bone morphogenesis cartilage development cation binding cell aggregation cell differentiation cell surface receptor signaling pathway cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular developmental process cellular process cellular response to BMP stimulus cellular response to endogenous stimulus cellular response to growth factor stimulus cellular_component central nervous system development chondrocyte differentiation collagen fibril organization collagen trimer collagen type II trimer collagen type XI trimer collagen-containing extracellular matrix developmental process embryonic morphogenesis embryonic organ development embryonic organ morphogenesis embryonic skeletal joint morphogenesis embryonic skeletal system morphogenesis endochondral ossification endoplasmic reticulum lumen epithelium development external encapsulating structure organization external encapsulating structure extracellular matrix organization extracellular matrix structural constituent conferring tensile strength extracellular matrix structural constituent extracellular matrix extracellular region extracellular space extracellular structure organization extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway fibrillar collagen trimer glycoprotein metabolic process growth factor binding head development heart morphogenesis homeostatic process identical protein binding inner ear development inner ear morphogenesis intracellular organelle lumen ion binding limb bud formation macromolecule metabolic process membrane-enclosed lumen metabolic process metal ion binding molecular_function multicellular organismal process multicellular organismal-level homeostasis negative regulation of apoptotic process negative regulation of apoptotic signaling pathway negative regulation of biological process negative regulation of cell communication negative regulation of cellular process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of programmed cell death negative regulation of response to stimulus negative regulation of signal transduction in absence of ligand negative regulation of signal transduction negative regulation of signaling nervous system process nitrogen compound metabolic process notochord development organelle lumen organic substance metabolic process organonitrogen compound metabolic process ossification otic vesicle development platelet-derived growth factor binding primary metabolic process protein binding protein dimerization activity protein homodimerization activity protein metabolic process protein-containing complex proteoglycan binding proteoglycan metabolic process regulation of apoptotic process regulation of apoptotic signaling pathway regulation of biological process regulation of biosynthetic process regulation of cell communication regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of extrinsic apoptotic signaling pathway regulation of gene expression regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of programmed cell death regulation of response to stimulus regulation of signal transduction regulation of signaling replacement ossification response to BMP response to endogenous stimulus response to growth factor response to stimulus roof of mouth development sensory organ development sensory perception of light stimulus sensory perception of mechanical stimulus sensory perception of sound sensory perception signal transduction in absence of ligand signal transduction signaling receptor binding skeletal system development skeletal system morphogenesis structural molecule activity supramolecular fiber organization system development system process tissue development tissue homeostasis tube development visual perception	GO:0001501 GO:0001502 GO:0001503 GO:0001894 GO:0001958 GO:0002062 GO:0003007 GO:0003008 GO:0003674 GO:0005102 GO:0005198 GO:0005201 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005581 GO:0005583 GO:0005585 GO:0005592 GO:0005604 GO:0005615 GO:0005788 GO:0006029 GO:0006807 GO:0007165 GO:0007166 GO:0007417 GO:0007423 GO:0007600 GO:0007601 GO:0007605 GO:0008150 GO:0008152 GO:0009100 GO:0009653 GO:0009719 GO:0009887 GO:0009888 GO:0009889 GO:0009966 GO:0009968 GO:0009987 GO:0010468 GO:0010556 GO:0010646 GO:0010648 GO:0016043 GO:0019222 GO:0019538 GO:0019838 GO:0023051 GO:0023057 GO:0030020 GO:0030154 GO:0030198 GO:0030199 GO:0030312 GO:0030903 GO:0031012 GO:0031323 GO:0031326 GO:0031974 GO:0032501 GO:0032502 GO:0032991 GO:0035295 GO:0036075 GO:0038034 GO:0042287 GO:0042289 GO:0042472 GO:0042592 GO:0042802 GO:0042803 GO:0042981 GO:0043062 GO:0043066 GO:0043067 GO:0043069 GO:0043167 GO:0043169 GO:0043170 GO:0043233 GO:0043394 GO:0044238 GO:0045229 GO:0046872 GO:0046983 GO:0048407 GO:0048513 GO:0048519 GO:0048523 GO:0048562 GO:0048568 GO:0048583 GO:0048585 GO:0048598 GO:0048646 GO:0048704 GO:0048705 GO:0048731 GO:0048839 GO:0048856 GO:0048869 GO:0048871 GO:0050789 GO:0050794 GO:0050877 GO:0050896 GO:0050953 GO:0050954 GO:0051216 GO:0060021 GO:0060174 GO:0060249 GO:0060255 GO:0060272 GO:0060322 GO:0060351 GO:0060429 GO:0062023 GO:0065007 GO:0070013 GO:0070848 GO:0071363 GO:0071495 GO:0071599 GO:0071704 GO:0071772 GO:0071773 GO:0071840 GO:0097065 GO:0097190 GO:0097191 GO:0097192 GO:0097367 GO:0097435 GO:0098743 GO:0110165 GO:1901099 GO:1901135 GO:1901564 GO:2001233 GO:2001234 GO:2001236 GO:2001237 GO:2001239 GO:2001240
9762	leucine zipper tumor suppressor family member 3	LZTS3	Homo sapiens (human)	9606			biological regulation biological_process cell junction cell projection cellular anatomical entity cellular_component cytoplasm cytoskeleton dendritic spine intracellular non-membrane-bounded organelle intracellular organelle neuron projection neuron spine non-membrane-bounded organelle organelle plasma membrane bounded cell projection postsynapse postsynaptic density postsynaptic specialization regulation of anatomical structure morphogenesis regulation of biological process regulation of cell projection organization regulation of cellular component organization regulation of cellular process regulation of dendritic spine morphogenesis regulation of developmental process regulation of neuron projection development regulation of plasma membrane bounded cell projection organization regulation of postsynapse organization regulation of synapse organization synapse	GO:0005575 GO:0005737 GO:0005856 GO:0008150 GO:0010975 GO:0014069 GO:0022603 GO:0030054 GO:0031344 GO:0042995 GO:0043005 GO:0043197 GO:0043226 GO:0043228 GO:0043229 GO:0043232 GO:0044309 GO:0045202 GO:0050789 GO:0050793 GO:0050794 GO:0050807 GO:0051128 GO:0061001 GO:0065007 GO:0098794 GO:0099175 GO:0099572 GO:0110165 GO:0120025 GO:0120035
146909	kinesin family member 18B	KIF18B	Homo sapiens (human)	9606			ATP binding ATP hydrolysis activity ATP-dependent activity adenyl nucleotide binding adenyl ribonucleotide binding anion binding astral microtubule binding biological regulation biological_process carbohydrate derivative binding catalytic activity cell cycle process cell cycle cell division cellular anatomical entity cellular component disassembly cellular component organization or biogenesis cellular component organization cellular process cellular_component chromosome organization chromosome segregation cytoplasm cytoplasmic microtubule cytoskeletal motor activity cytoskeletal protein binding cytoskeleton organization cytosol heterocyclic compound binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides hydrolase activity intracellular membrane-bounded organelle intracellular organelle ion binding kinesin binding kinesin complex membrane-bounded organelle microtubule associated complex microtubule binding microtubule cytoskeleton organization microtubule depolymerization microtubule end microtubule motor activity microtubule plus-end microtubule polymerization or depolymerization microtubule-based movement microtubule-based process microtubule mitotic cell cycle process mitotic cell cycle mitotic sister chromatid segregation mitotic spindle astral microtubule mitotic spindle midzone molecular_function nuclear body nuclear chromosome segregation nucleoplasm nucleoside phosphate binding nucleotide binding nucleus organelle organization organelle organic cyclic compound binding plus-end-directed microtubule motor activity polymeric cytoskeletal fiber protein binding protein depolymerization protein-containing complex disassembly protein-containing complex organization protein-containing complex purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding pyrophosphatase activity regulation of biological process regulation of cell division regulation of cellular process ribonucleoside triphosphate phosphatase activity ribonucleotide binding sister chromatid segregation small molecule binding spindle microtubule spindle midzone supramolecular complex supramolecular fiber organization supramolecular fiber supramolecular polymer tubulin binding	GO:0000070 GO:0000166 GO:0000226 GO:0000235 GO:0000278 GO:0000819 GO:0003674 GO:0003774 GO:0003777 GO:0003824 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005871 GO:0005874 GO:0005875 GO:0005876 GO:0005881 GO:0006996 GO:0007010 GO:0007017 GO:0007018 GO:0007019 GO:0007049 GO:0007059 GO:0008017 GO:0008092 GO:0008150 GO:0008574 GO:0009987 GO:0015631 GO:0016043 GO:0016462 GO:0016604 GO:0016787 GO:0016817 GO:0016818 GO:0016887 GO:0017076 GO:0017111 GO:0019894 GO:0022402 GO:0022411 GO:0030554 GO:0031109 GO:0032553 GO:0032555 GO:0032559 GO:0032984 GO:0032991 GO:0035371 GO:0035639 GO:0036094 GO:0043167 GO:0043168 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043933 GO:0050789 GO:0050794 GO:0051233 GO:0051261 GO:0051276 GO:0051301 GO:0051302 GO:0061673 GO:0065007 GO:0071840 GO:0097159 GO:0097367 GO:0097435 GO:0098813 GO:0099080 GO:0099081 GO:0099512 GO:0099513 GO:0110165 GO:0140657 GO:1901265 GO:1901363 GO:1903047 GO:1990023 GO:1990752
6317	serpin family B member 3	SERPINB3	Homo sapiens (human)	9606			autocrine signaling azurophil granule lumen binding biological process involved in interaction with host biological process involved in interspecies interaction between organisms biological process involved in symbiotic interaction biological regulation biological_process cell communication cell-cell signaling cellular anatomical entity cellular process cellular_component cysteine-type endopeptidase inhibitor activity cytoplasm cytoplasmic vesicle lumen cytoplasmic vesicle cytosol endopeptidase inhibitor activity endopeptidase regulator activity entry into host enzyme binding enzyme inhibitor activity enzyme regulator activity exogenous protein binding extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular region extracellular space extracellular vesicle intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle intracellular vesicle membrane-bounded organelle membrane-enclosed lumen membrane molecular function inhibitor activity molecular function regulator activity molecular_function movement in host negative regulation of JNK cascade negative regulation of JUN kinase activity negative regulation of MAP kinase activity negative regulation of MAPK cascade negative regulation of biological process negative regulation of catalytic activity negative regulation of cell communication negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of endopeptidase activity negative regulation of hydrolase activity negative regulation of intracellular signal transduction negative regulation of kinase activity negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of molecular function negative regulation of nitrogen compound metabolic process negative regulation of peptidase activity negative regulation of phosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of phosphorylation negative regulation of protein kinase activity negative regulation of protein metabolic process negative regulation of protein modification process negative regulation of protein phosphorylation negative regulation of protein serine/threonine kinase activity negative regulation of proteolysis negative regulation of response to stimulus negative regulation of signal transduction negative regulation of signaling negative regulation of stress-activated MAPK cascade negative regulation of stress-activated protein kinase signaling cascade negative regulation of transferase activity nucleus organelle lumen organelle paracrine signaling peptidase inhibitor activity peptidase regulator activity plasma membrane positive regulation of biological process positive regulation of catalytic activity positive regulation of cell differentiation positive regulation of cell migration positive regulation of cell motility positive regulation of cell population proliferation positive regulation of cellular process positive regulation of developmental process positive regulation of endopeptidase activity positive regulation of epithelial to mesenchymal transition positive regulation of hydrolase activity positive regulation of locomotion positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of multicellular organismal process positive regulation of nitrogen compound metabolic process positive regulation of peptidase activity positive regulation of protein metabolic process positive regulation of proteolysis protease binding protein binding regulation of JNK cascade regulation of JUN kinase activity regulation of MAP kinase activity regulation of MAPK cascade regulation of biological process regulation of catalytic activity regulation of cell communication regulation of cell differentiation regulation of cell migration regulation of cell motility regulation of cell population proliferation regulation of cellular metabolic process regulation of cellular process regulation of cellular response to stress regulation of developmental process regulation of endopeptidase activity regulation of epithelial to mesenchymal transition regulation of hydrolase activity regulation of intracellular signal transduction regulation of kinase activity regulation of locomotion regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of peptidase activity regulation of phosphate metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of primary metabolic process regulation of protein kinase activity regulation of protein metabolic process regulation of protein modification process regulation of protein phosphorylation regulation of protein serine/threonine kinase activity regulation of proteolysis regulation of response to stimulus regulation of response to stress regulation of signal transduction regulation of signaling regulation of stress-activated MAPK cascade regulation of stress-activated protein kinase signaling cascade regulation of transferase activity secretory granule lumen serine-type endopeptidase inhibitor activity signaling vacuolar lumen vesicle lumen vesicle viral entry into host cell virus receptor activity	GO:0001618 GO:0001932 GO:0001933 GO:0002020 GO:0003674 GO:0004857 GO:0004866 GO:0004867 GO:0004869 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005775 GO:0005829 GO:0005886 GO:0006469 GO:0007154 GO:0007267 GO:0008150 GO:0008284 GO:0009892 GO:0009893 GO:0009966 GO:0009968 GO:0009987 GO:0010466 GO:0010563 GO:0010604 GO:0010605 GO:0010646 GO:0010648 GO:0010717 GO:0010718 GO:0010950 GO:0010951 GO:0010952 GO:0016020 GO:0019220 GO:0019222 GO:0019899 GO:0023051 GO:0023052 GO:0023057 GO:0030162 GO:0030234 GO:0030334 GO:0030335 GO:0030414 GO:0031323 GO:0031324 GO:0031399 GO:0031400 GO:0031410 GO:0031974 GO:0031982 GO:0031983 GO:0032872 GO:0032873 GO:0033673 GO:0034774 GO:0035425 GO:0035578 GO:0038001 GO:0040012 GO:0040017 GO:0042127 GO:0042325 GO:0042326 GO:0043085 GO:0043086 GO:0043226 GO:0043227 GO:0043229 GO:0043230 GO:0043231 GO:0043233 GO:0043405 GO:0043407 GO:0043408 GO:0043409 GO:0043506 GO:0043508 GO:0043549 GO:0044000 GO:0044092 GO:0044093 GO:0044403 GO:0044409 GO:0044419 GO:0045595 GO:0045597 GO:0045859 GO:0045861 GO:0045862 GO:0045936 GO:0046328 GO:0046329 GO:0046718 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048585 GO:0050789 GO:0050790 GO:0050793 GO:0050794 GO:0051094 GO:0051171 GO:0051172 GO:0051173 GO:0051174 GO:0051239 GO:0051240 GO:0051246 GO:0051247 GO:0051248 GO:0051336 GO:0051338 GO:0051345 GO:0051346 GO:0051348 GO:0051701 GO:0052547 GO:0052548 GO:0060205 GO:0060255 GO:0061134 GO:0061135 GO:0065007 GO:0065009 GO:0065010 GO:0070013 GO:0070062 GO:0070302 GO:0070303 GO:0071900 GO:0071901 GO:0080090 GO:0080134 GO:0080135 GO:0097708 GO:0098772 GO:0110165 GO:0140272 GO:0140678 GO:1902531 GO:1902532 GO:1903561 GO:2000145 GO:2000147
284297	scavenger receptor cysteine rich family member with 5 domains	SSC5D	Homo sapiens (human)	9606			binding biological process involved in interspecies interaction between organisms biological regulation biological_process cargo receptor activity cellular anatomical entity cellular process cellular_component collagen-containing extracellular matrix cytoplasm defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to bacterium defense response to other organism defense response detection of bacterial lipoprotein detection of biotic stimulus detection of chemical stimulus detection of external biotic stimulus detection of molecule of bacterial origin detection of stimulus establishment of localization external encapsulating structure extracellular matrix binding extracellular matrix extracellular space fibronectin binding immune response immune system process innate immune response laminin binding localization membrane molecular_function negative regulation of biological process negative regulation of biosynthetic process negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of cytokine production negative regulation of gene expression negative regulation of interleukin-8 production negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process protein binding regulation of biological process regulation of biosynthetic process regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cytokine production regulation of gene expression regulation of interleukin-8 production regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process response to bacterial lipoprotein response to bacterium response to biotic stimulus response to chemical response to external biotic stimulus response to external stimulus response to molecule of bacterial origin response to organic substance response to other organism response to stimulus response to stress scavenger receptor activity transport vesicle-mediated transport	GO:0001817 GO:0001818 GO:0001968 GO:0002237 GO:0002376 GO:0003674 GO:0005044 GO:0005488 GO:0005515 GO:0005575 GO:0005615 GO:0005737 GO:0006810 GO:0006950 GO:0006952 GO:0006955 GO:0008150 GO:0009593 GO:0009595 GO:0009605 GO:0009607 GO:0009617 GO:0009889 GO:0009890 GO:0009892 GO:0009987 GO:0010033 GO:0010468 GO:0010556 GO:0010558 GO:0010605 GO:0010629 GO:0016020 GO:0016192 GO:0019222 GO:0030312 GO:0031012 GO:0031323 GO:0031324 GO:0031326 GO:0031327 GO:0032490 GO:0032493 GO:0032677 GO:0032717 GO:0038024 GO:0042221 GO:0042494 GO:0042742 GO:0043207 GO:0043236 GO:0044419 GO:0045087 GO:0048519 GO:0048523 GO:0050789 GO:0050794 GO:0050829 GO:0050830 GO:0050840 GO:0050896 GO:0051179 GO:0051234 GO:0051239 GO:0051241 GO:0051606 GO:0051707 GO:0060255 GO:0062023 GO:0065007 GO:0098542 GO:0098581 GO:0110165
23366	microtubule associated tyrosine carboxypeptidase 2	MATCAP2	Homo sapiens (human)	9606			binding biological_process carboxypeptidase activity catalytic activity, acting on a protein catalytic activity cation binding exopeptidase activity hydrolase activity ion binding macromolecule metabolic process metabolic process metal ion binding metallopeptidase activity molecular_function nitrogen compound metabolic process organic substance metabolic process organonitrogen compound metabolic process peptidase activity primary metabolic process protein metabolic process proteolysis	GO:0003674 GO:0003824 GO:0004180 GO:0005488 GO:0006508 GO:0006807 GO:0008150 GO:0008152 GO:0008233 GO:0008237 GO:0008238 GO:0016787 GO:0019538 GO:0043167 GO:0043169 GO:0043170 GO:0044238 GO:0046872 GO:0071704 GO:0140096 GO:1901564
60509	AGBL carboxypeptidase 5	AGBL5	Homo sapiens (human)	9606			C-terminal protein amino acid modification C-terminal protein deglutamylation binding biological process involved in interspecies interaction between organisms biological_process carboxypeptidase activity catalytic activity, acting on a protein catalytic activity cation binding cellular anatomical entity cellular_component cytoplasm cytoskeletal protein binding cytoskeleton cytosol defense response to other organism defense response to symbiont defense response to virus defense response exopeptidase activity hydrolase activity intercellular bridge intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle ion binding macromolecule metabolic process macromolecule modification membrane-bounded organelle metabolic process metal ion binding metallocarboxypeptidase activity metalloexopeptidase activity metallopeptidase activity microtubule cytoskeleton midbody mitotic spindle molecular_function nitrogen compound metabolic process non-membrane-bounded organelle nucleus organelle organic substance metabolic process organonitrogen compound metabolic process peptidase activity peptidyl-amino acid modification peptidyl-glutamic acid modification post-translational protein modification primary metabolic process protein binding protein branching point deglutamylation protein deglutamylation protein metabolic process protein modification process protein side chain deglutamylation proteolysis response to biotic stimulus response to external biotic stimulus response to external stimulus response to other organism response to stimulus response to stress response to virus spindle transition metal ion binding tubulin binding zinc ion binding	GO:0003674 GO:0003824 GO:0004180 GO:0004181 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005737 GO:0005819 GO:0005829 GO:0005856 GO:0006508 GO:0006807 GO:0006950 GO:0006952 GO:0008092 GO:0008150 GO:0008152 GO:0008233 GO:0008235 GO:0008237 GO:0008238 GO:0008270 GO:0009605 GO:0009607 GO:0009615 GO:0015630 GO:0015631 GO:0016787 GO:0018193 GO:0018200 GO:0018410 GO:0019538 GO:0030496 GO:0035608 GO:0035609 GO:0035610 GO:0035611 GO:0036211 GO:0043167 GO:0043169 GO:0043170 GO:0043207 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043412 GO:0043687 GO:0044238 GO:0044419 GO:0045171 GO:0046872 GO:0046914 GO:0050896 GO:0051607 GO:0051707 GO:0071704 GO:0072686 GO:0098542 GO:0110165 GO:0140096 GO:0140546 GO:1901564
54842	major facilitator superfamily domain containing 6	MFSD6	Homo sapiens (human)	9606			antigen processing and presentation of exogenous antigen antigen processing and presentation of exogenous peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of peptide antigen antigen processing and presentation binding biological_process cellular anatomical entity cellular_component immune system process membrane molecular_function plasma membrane protein binding	GO:0002376 GO:0002474 GO:0002478 GO:0003674 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0008150 GO:0016020 GO:0019882 GO:0019884 GO:0042590 GO:0048002 GO:0110165
51179	hydroxyacid oxidase 2	HAO2 Aliases: (S)-2-hydroxy-acid oxidase GIG16 HAOX2 glycolate oxidase growth-inhibiting protein 16 long-chain L-2-hydroxy acid oxidase	Homo sapiens (human)	9606	cancer cholestasis chromophobe renal cell carcinoma clear cell renal cell carcinoma collecting duct carcinoma embryoma familial hyperinsulinemic hypoglycemia 1 familial hyperinsulinemic hypoglycemia 2 hepatocellular carcinoma hyperinsulinemic hypoglycemia inherited metabolic disorder liver cancer nonpapillary renal cell carcinoma papillary renal cell carcinoma primary hyperoxaluria renal carcinoma renal cell carcinoma sarcomatoid renal cell carcinoma	DOID:0050387 DOID:0070218 DOID:0070219 DOID:13317 DOID:13580 DOID:162 DOID:2977 DOID:3571 DOID:4450 DOID:4451 DOID:4464 DOID:4465 DOID:4467 DOID:4471 DOID:4473 DOID:4766 DOID:655 DOID:684	(S)-2-hydroxy-acid oxidase activity FMN binding anion binding binding biological_process carbohydrate derivative binding carboxylic acid catabolic process carboxylic acid metabolic process catabolic process catalytic activity cellular anatomical entity cellular catabolic process cellular lipid catabolic process cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytosol fatty acid alpha-oxidation fatty acid catabolic process fatty acid metabolic process fatty acid oxidation heterocyclic compound binding intracellular organelle lumen ion binding lipid catabolic process lipid metabolic process lipid modification lipid oxidation membrane-enclosed lumen metabolic process microbody lumen molecular_function monocarboxylic acid catabolic process monocarboxylic acid metabolic process nucleoside phosphate binding nucleotide binding organelle lumen organic acid catabolic process organic acid metabolic process organic cyclic compound binding organic substance catabolic process organic substance metabolic process oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor oxidoreductase activity oxoacid metabolic process peroxisomal matrix primary metabolic process protein binding ribonucleotide binding small molecule binding small molecule catabolic process small molecule metabolic process	GO:0000166 GO:0001561 GO:0003674 GO:0003824 GO:0003973 GO:0005488 GO:0005515 GO:0005575 GO:0005782 GO:0005829 GO:0006082 GO:0006629 GO:0006631 GO:0008150 GO:0008152 GO:0009056 GO:0009062 GO:0009987 GO:0010181 GO:0016042 GO:0016054 GO:0016491 GO:0016614 GO:0016899 GO:0019395 GO:0019752 GO:0030258 GO:0031907 GO:0031974 GO:0032553 GO:0032787 GO:0034440 GO:0036094 GO:0043167 GO:0043168 GO:0043233 GO:0043436 GO:0044237 GO:0044238 GO:0044242 GO:0044248 GO:0044255 GO:0044281 GO:0044282 GO:0046395 GO:0070013 GO:0071704 GO:0072329 GO:0097159 GO:0097367 GO:0110165 GO:1901265 GO:1901363 GO:1901575
4327	matrix metallopeptidase 19	MMP19	Homo sapiens (human)	9606			anatomical structure formation involved in morphogenesis angiogenesis binding biological_process catabolic process catalytic activity, acting on a protein catalytic activity cation binding cell differentiation cellular anatomical entity cellular component disassembly cellular component organization or biogenesis cellular component organization cellular developmental process cellular process cellular_component collagen catabolic process collagen metabolic process developmental process endopeptidase activity external encapsulating structure organization external encapsulating structure extracellular matrix disassembly extracellular matrix organization extracellular matrix extracellular region extracellular space extracellular structure organization hydrolase activity ion binding macromolecule metabolic process metabolic process metal ion binding metalloendopeptidase activity metallopeptidase activity molecular_function nitrogen compound metabolic process organic substance metabolic process organonitrogen compound metabolic process peptidase activity primary metabolic process protein metabolic process proteolysis serine hydrolase activity serine-type endopeptidase activity serine-type peptidase activity transition metal ion binding zinc ion binding	GO:0001525 GO:0003674 GO:0003824 GO:0004175 GO:0004222 GO:0004252 GO:0005488 GO:0005575 GO:0005576 GO:0005615 GO:0006508 GO:0006807 GO:0008150 GO:0008152 GO:0008233 GO:0008236 GO:0008237 GO:0008270 GO:0009056 GO:0009987 GO:0016043 GO:0016787 GO:0017171 GO:0019538 GO:0022411 GO:0022617 GO:0030154 GO:0030198 GO:0030312 GO:0030574 GO:0031012 GO:0032502 GO:0032963 GO:0043062 GO:0043167 GO:0043169 GO:0043170 GO:0044238 GO:0045229 GO:0046872 GO:0046914 GO:0048646 GO:0048869 GO:0071704 GO:0071840 GO:0110165 GO:0140096 GO:1901564
8540	alkylglycerone phosphate synthase	AGPS Aliases: ADAP-S ADAS ADHAPS ADPS ALDHPSY	Homo sapiens (human)	9606	Alzheimer's disease 10 Alzheimer's disease 11 Alzheimer's disease 12 Alzheimer's disease 13 Alzheimer's disease 14 Alzheimer's disease 15 Alzheimer's disease 1 Alzheimer's disease 2 Alzheimer's disease 5 Alzheimer's disease 6 Alzheimer's disease 7 Alzheimer's disease 8 Alzheimer's disease Pick's disease Reye syndrome X-linked chondrodysplasia punctata 1 Zellweger syndrome agammaglobulinemia amyloidosis autosomal dominant chondrodysplasia punctata cancer central nervous system cancer cerebral degeneration chondrodysplasia punctata congenital generalized lipodystrophy type 1 congenital generalized lipodystrophy dementia embryoma epilepsy essential hypertension gliosarcoma hepatocellular carcinoma high grade glioma hypertension liver cancer lymphopenia mixed glioma peroxisome biogenesis disorder 1A photoallergic dermatitis rhizomelic chondrodysplasia punctata type 1 rhizomelic chondrodysplasia punctata type 2 rhizomelic chondrodysplasia punctata type 3 rhizomelic chondrodysplasia punctata thyroid adenoma thyroid cancer thyroid gland carcinoma visual epilepsy	DOID:0050585 DOID:0060292 DOID:0060293 DOID:0080348 DOID:0080476 DOID:0110035 DOID:0110037 DOID:0110038 DOID:0110039 DOID:0110041 DOID:0110043 DOID:0110044 DOID:0110045 DOID:0110046 DOID:0110047 DOID:0110048 DOID:0110851 DOID:0110852 DOID:0110853 DOID:0111135 DOID:10652 DOID:10763 DOID:10825 DOID:11832 DOID:11870 DOID:1307 DOID:1443 DOID:14525 DOID:162 DOID:1781 DOID:1826 DOID:2580 DOID:2581 DOID:2583 DOID:2891 DOID:3070 DOID:3071 DOID:3571 DOID:3620 DOID:3818 DOID:3963 DOID:4766 DOID:5076 DOID:614 DOID:684 DOID:905 DOID:9120	FAD binding alkylglycerone-phosphate synthase activity anion binding binding biological_process biosynthetic process bounding membrane of organelle catalytic activity cellular anatomical entity cellular biosynthetic process cellular lipid biosynthetic process cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytosol ether biosynthetic process ether lipid biosynthetic process ether lipid metabolic process ether metabolic process flavin adenine dinucleotide binding glycerol ether biosynthetic process glycerol ether metabolic process heterocyclic compound binding intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle ion binding lipid biosynthetic process lipid metabolic process membrane-bounded organelle membrane-enclosed lumen membrane metabolic process microbody lumen microbody membrane microbody mitochondrion molecular_function nucleoside phosphate binding nucleotide binding organelle lumen organelle membrane organelle organic cyclic compound binding organic substance biosynthetic process organic substance metabolic process peroxisomal matrix peroxisomal membrane peroxisome primary metabolic process protein binding small molecule binding small molecule metabolic process transferase activity, transferring alkyl or aryl (other than methyl) groups transferase activity	GO:0000166 GO:0003674 GO:0003824 GO:0005488 GO:0005515 GO:0005575 GO:0005739 GO:0005777 GO:0005778 GO:0005782 GO:0005829 GO:0006629 GO:0006662 GO:0008150 GO:0008152 GO:0008609 GO:0008610 GO:0008611 GO:0009058 GO:0009987 GO:0016020 GO:0016740 GO:0016765 GO:0018904 GO:0031090 GO:0031903 GO:0031907 GO:0031974 GO:0036094 GO:0042579 GO:0043167 GO:0043168 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043233 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0044281 GO:0046485 GO:0046504 GO:0050660 GO:0070013 GO:0071704 GO:0071949 GO:0097159 GO:0097384 GO:0098588 GO:0110165 GO:1901265 GO:1901363 GO:1901503 GO:1901576
6472	serine hydroxymethyltransferase 2	SHMT2 Aliases: mSHMT mitochondrial serine hydroxymethyltransferase	Homo sapiens (human)	9606	B-cell lymphoma Down syndrome Langerhans-cell histiocytosis Parkinson's disease 19A Parkinson's disease 23 Parkinson's disease 4 Parkinson's disease alcohol use disorder anemia arthritis arthropathy autistic disorder breast cancer breast carcinoma bronchus cancer bronchus carcinoma cancer central nervous system cancer cholangiocarcinoma colon cancer colon carcinoma colonic benign neoplasm colorectal cancer colorectal carcinoma embryoma esophageal cancer esophageal carcinoma esophagus squamous cell carcinoma gastrointestinal system cancer gliosarcoma head and neck squamous cell carcinoma hepatitis B hepatocellular carcinoma high grade glioma idiopathic interstitial pneumonia idiopathic pulmonary fibrosis intrahepatic cholangiocarcinoma large intestine cancer liver cancer liver carcinoma lung benign neoplasm lung cancer lung carcinoma lung non-small cell carcinoma lymphoma macrocytic anemia mixed glioma neuroblastoma non-Hodgkin lymphoma obsolete ymphosarcoma osteoarthritis prostate cancer prostate carcinoma reticulosarcoma schizophrenia stomach cancer stomach carcinoma	DOID:0050156 DOID:0060058 DOID:0060060 DOID:0060891 DOID:0060895 DOID:0060896 DOID:0080199 DOID:10283 DOID:10286 DOID:10534 DOID:1107 DOID:12849 DOID:1324 DOID:1325 DOID:14250 DOID:14330 DOID:1520 DOID:1574 DOID:1612 DOID:162 DOID:2043 DOID:219 DOID:235 DOID:2355 DOID:2361 DOID:2571 DOID:2797 DOID:3070 DOID:3071 DOID:3119 DOID:3459 DOID:3571 DOID:3620 DOID:3683 DOID:3748 DOID:381 DOID:3904 DOID:3905 DOID:3908 DOID:4766 DOID:4928 DOID:4947 DOID:5041 DOID:5076 DOID:5419 DOID:5517 DOID:5520 DOID:5672 DOID:684 DOID:686 DOID:707 DOID:769 DOID:8398 DOID:848 DOID:8538 DOID:8675 DOID:9256	BRISC complex L-allo-threonine aldolase activity L-serine biosynthetic process L-serine metabolic process aldehyde-lyase activity alpha-amino acid biosynthetic process alpha-amino acid metabolic process amino acid binding amino acid biosynthetic process amino acid metabolic process anion binding binding biological regulation biological_process biosynthetic process carbon-carbon lyase activity carboxylic acid binding carboxylic acid biosynthetic process carboxylic acid metabolic process catalytic activity cellular anatomical entity cellular aromatic compound metabolic process cellular biosynthetic process cellular component assembly cellular component organization or biogenesis cellular component organization cellular metabolic process cellular modified amino acid metabolic process cellular process cellular_component chromatin binding cytoplasm cytoskeleton extracellular exosome extracellular membrane-bounded organelle extracellular organelle extracellular vesicle folic acid-containing compound metabolic process glycine biosynthetic process from serine glycine biosynthetic process glycine hydroxymethyltransferase activity glycine metabolic process heterocycle metabolic process heterocyclic compound binding hydroxymethyl-, formyl- and related transferase activity identical protein binding intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle intracellular organelle lumen intracellular organelle ion binding lyase activity macromolecule metabolic process macromolecule modification membrane-bounded organelle membrane-enclosed lumen membrane metabolic process microtubule cytoskeleton mitochondrial inner membrane mitochondrial matrix mitochondrial membrane mitochondrial nucleoid mitochondrion molecular_function nitrogen compound metabolic process non-membrane-bounded organelle nuclear protein-containing complex nucleoid nucleus one-carbon metabolic process organelle inner membrane organelle lumen organelle membrane organelle organic acid binding organic acid biosynthetic process organic acid metabolic process organic cyclic compound binding organic cyclic compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound biosynthetic process organonitrogen compound metabolic process oxoacid metabolic process positive regulation of biological process positive regulation of cell population proliferation positive regulation of cellular process post-transcriptional regulation of gene expression post-translational protein modification primary metabolic process protein K63-linked deubiquitination protein binding protein complex oligomerization protein deubiquitination protein homooligomerization protein homotetramerization protein metabolic process protein modification by small protein conjugation or removal protein modification by small protein removal protein modification process protein tetramerization protein-containing complex assembly protein-containing complex binding protein-containing complex organization protein-containing complex pteridine-containing compound metabolic process pyridoxal phosphate binding regulation of aerobic respiration regulation of amide metabolic process regulation of biological process regulation of biosynthetic process regulation of cell population proliferation regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cellular respiration regulation of gene expression regulation of generation of precursor metabolites and energy regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of mitochondrial gene expression regulation of mitochondrial translation regulation of nitrogen compound metabolic process regulation of oxidative phosphorylation regulation of primary metabolic process regulation of protein metabolic process regulation of translation response to chemical response to cytokine response to organic substance response to stimulus response to type I interferon serine family amino acid biosynthetic process serine family amino acid metabolic process small molecule binding small molecule biosynthetic process small molecule metabolic process tetrahydrofolate interconversion tetrahydrofolate metabolic process threonine aldolase activity transferase activity, transferring one-carbon groups transferase activity vesicle vitamin B6 binding vitamin binding	GO:0002082 GO:0003674 GO:0003682 GO:0003824 GO:0004372 GO:0004793 GO:0005488 GO:0005515 GO:0005575 GO:0005634 GO:0005737 GO:0005739 GO:0005743 GO:0005759 GO:0005856 GO:0006082 GO:0006417 GO:0006520 GO:0006544 GO:0006545 GO:0006563 GO:0006564 GO:0006575 GO:0006725 GO:0006730 GO:0006760 GO:0006807 GO:0008150 GO:0008152 GO:0008284 GO:0008652 GO:0008732 GO:0009058 GO:0009069 GO:0009070 GO:0009295 GO:0009889 GO:0009987 GO:0010033 GO:0010468 GO:0010556 GO:0010608 GO:0015630 GO:0016020 GO:0016043 GO:0016053 GO:0016579 GO:0016597 GO:0016740 GO:0016741 GO:0016742 GO:0016829 GO:0016830 GO:0016832 GO:0019222 GO:0019264 GO:0019538 GO:0019752 GO:0019842 GO:0019866 GO:0022607 GO:0030170 GO:0031090 GO:0031323 GO:0031326 GO:0031406 GO:0031966 GO:0031974 GO:0031982 GO:0032991 GO:0034097 GO:0034248 GO:0034340 GO:0035999 GO:0036094 GO:0036211 GO:0042127 GO:0042221 GO:0042558 GO:0042645 GO:0042802 GO:0043167 GO:0043168 GO:0043170 GO:0043177 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043230 GO:0043231 GO:0043232 GO:0043233 GO:0043412 GO:0043436 GO:0043457 GO:0043467 GO:0043687 GO:0043933 GO:0044237 GO:0044238 GO:0044249 GO:0044281 GO:0044283 GO:0044877 GO:0046394 GO:0046483 GO:0046653 GO:0048518 GO:0048522 GO:0050789 GO:0050794 GO:0050896 GO:0051171 GO:0051246 GO:0051259 GO:0051260 GO:0051262 GO:0051289 GO:0060255 GO:0062125 GO:0065003 GO:0065007 GO:0065010 GO:0070013 GO:0070062 GO:0070129 GO:0070279 GO:0070536 GO:0070552 GO:0070646 GO:0070647 GO:0071704 GO:0071840 GO:0080090 GO:0097159 GO:0110165 GO:0140513 GO:1901360 GO:1901363 GO:1901564 GO:1901566 GO:1901576 GO:1901605 GO:1901607 GO:1903561 GO:1903715
124976	SPNS lysolipid transporter 2, sphingosine-1-phosphate	SPNS2	Homo sapiens (human)	9606			B cell homeostasis G protein-coupled receptor signaling pathway T cell homeostasis anatomical structure development animal organ development biological regulation biological_process biosynthetic process bone development bounding membrane of organelle cell migration cell motility cellular anatomical entity cellular biosynthetic process cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytoplasmic vesicle membrane developmental process endosome membrane establishment of localization hematopoietic or lymphoid organ development homeostasis of number of cells homeostatic process immune system process leukocyte homeostasis leukocyte migration lipid biosynthetic process lipid metabolic process lipid transport lipid transporter activity localization lymph node development lymphocyte homeostasis lymphocyte migration membrane lipid biosynthetic process membrane lipid metabolic process membrane metabolic process molecular_function mononuclear cell migration multicellular organismal process multicellular organismal-level homeostasis nervous system process nitrogen compound metabolic process organelle membrane organic substance biosynthetic process organic substance metabolic process organic substance transport organonitrogen compound biosynthetic process organonitrogen compound metabolic process plasma membrane primary metabolic process regulation of T cell migration regulation of biological process regulation of cell migration regulation of cell motility regulation of cellular process regulation of developmental pigmentation regulation of eye pigmentation regulation of humoral immune response regulation of immune response regulation of immune system process regulation of leukocyte migration regulation of locomotion regulation of lymphocyte migration regulation of mononuclear cell migration regulation of pigmentation regulation of response to stimulus sensory perception of mechanical stimulus sensory perception of sound sensory perception signal transduction sphingolipid biosynthetic process sphingolipid mediated signaling pathway sphingolipid metabolic process sphingolipid transporter activity sphingosine-1-phosphate receptor signaling pathway system process transmembrane transport transmembrane transporter activity transport transporter activity vesicle membrane	GO:0001776 GO:0001782 GO:0002260 GO:0002376 GO:0002682 GO:0002685 GO:0002920 GO:0003008 GO:0003376 GO:0003674 GO:0005215 GO:0005319 GO:0005575 GO:0005886 GO:0006629 GO:0006643 GO:0006665 GO:0006807 GO:0006810 GO:0006869 GO:0007165 GO:0007186 GO:0007600 GO:0007605 GO:0008150 GO:0008152 GO:0008610 GO:0009058 GO:0009987 GO:0010008 GO:0012506 GO:0016020 GO:0016477 GO:0022857 GO:0030148 GO:0030334 GO:0030659 GO:0031090 GO:0032501 GO:0032502 GO:0040012 GO:0042592 GO:0043029 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0046467 GO:0046624 GO:0048070 GO:0048073 GO:0048513 GO:0048534 GO:0048535 GO:0048583 GO:0048856 GO:0048870 GO:0048871 GO:0048872 GO:0050776 GO:0050789 GO:0050794 GO:0050877 GO:0050900 GO:0050954 GO:0051179 GO:0051234 GO:0055085 GO:0060348 GO:0065007 GO:0071674 GO:0071675 GO:0071702 GO:0071704 GO:0072676 GO:0090520 GO:0098588 GO:0110165 GO:0120305 GO:1901564 GO:1901566 GO:1901576 GO:2000145 GO:2000401 GO:2000404
80821	DDHD domain containing 1	DDHD1 Aliases: KIAA1705 PA-PLA1 PAPLA1 iPLA1alpha intracellular phospholipase A1 alpha phosphatidic acid-preferring phospholipase A1	Homo sapiens (human)	9606			binding biological regulation biological_process carboxylic ester hydrolase activity catalytic activity cation binding cellular anatomical entity cellular lipid metabolic process cellular metabolic process cellular process cellular_component cytoplasm cytosol glycerolipid metabolic process glycerophospholipid metabolic process hydrolase activity, acting on ester bonds hydrolase activity ion binding lipase activity lipid metabolic process metabolic process metal ion binding molecular_function organic substance metabolic process organophosphate metabolic process phosphate-containing compound metabolic process phosphatidylinositol metabolic process phospholipase A1 activity phospholipase activity phospholipid metabolic process phosphorus metabolic process positive regulation of biological process positive regulation of cellular component organization positive regulation of cellular process positive regulation of developmental process positive regulation of mitochondrial fission positive regulation of mitochondrion organization positive regulation of organelle organization primary metabolic process protein binding regulation of anatomical structure morphogenesis regulation of biological process regulation of cellular component organization regulation of cellular process regulation of developmental process regulation of mitochondrial fission regulation of mitochondrion organization regulation of organelle organization	GO:0003674 GO:0003824 GO:0004620 GO:0005488 GO:0005515 GO:0005575 GO:0005737 GO:0005829 GO:0006629 GO:0006644 GO:0006650 GO:0006793 GO:0006796 GO:0008150 GO:0008152 GO:0008970 GO:0009987 GO:0010638 GO:0010821 GO:0010822 GO:0016298 GO:0016787 GO:0016788 GO:0019637 GO:0022603 GO:0033043 GO:0043167 GO:0043169 GO:0044237 GO:0044238 GO:0044255 GO:0046486 GO:0046488 GO:0046872 GO:0048518 GO:0048522 GO:0050789 GO:0050793 GO:0050794 GO:0051094 GO:0051128 GO:0051130 GO:0052689 GO:0065007 GO:0071704 GO:0090140 GO:0090141 GO:0110165
79180	EF-hand domain family member D2	EFHD2	Homo sapiens (human)	9606			binding cadherin binding calcium ion binding cation binding cell adhesion molecule binding cellular anatomical entity cellular_component ion binding membrane microdomain membrane raft membrane metal ion binding molecular_function protein binding	GO:0003674 GO:0005488 GO:0005509 GO:0005515 GO:0005575 GO:0016020 GO:0043167 GO:0043169 GO:0045121 GO:0045296 GO:0046872 GO:0050839 GO:0098857 GO:0110165
116150	NUS1 dehydrodolichyl diphosphate synthase subunit	NUS1	Homo sapiens (human)	9606			alcohol biosynthetic process alcohol metabolic process anatomical structure formation involved in morphogenesis angiogenesis binding biological regulation biological_process biosynthetic process catalytic activity catalytic complex cation binding cell differentiation cell surface receptor signaling pathway cellular anatomical entity cellular biosynthetic process cellular developmental process cellular lipid metabolic process cellular metabolic process cellular process cellular_component chemical homeostasis cholesterol homeostasis dehydrodolichyl diphosphate synthase activity dehydrodolichyl diphosphate synthase complex developmental process dolichol biosynthetic process dolichol metabolic process dolichyl diphosphate biosynthetic process dolichyl diphosphate metabolic process endoplasmic reticulum membrane enzyme-linked receptor protein signaling pathway glycosylation homeostatic process ion binding isoprenoid biosynthetic process isoprenoid metabolic process lipid biosynthetic process lipid homeostasis lipid metabolic process macromolecule glycosylation macromolecule metabolic process macromolecule modification mannosylation membrane metabolic process metal ion binding molecular_function nitrogen compound metabolic process organelle membrane organic hydroxy compound biosynthetic process organic hydroxy compound metabolic process organic substance biosynthetic process organic substance metabolic process organonitrogen compound metabolic process organophosphate biosynthetic process organophosphate metabolic process phosphate-containing compound metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphorus metabolic process polyprenol biosynthetic process polyprenol metabolic process positive regulation of biological process positive regulation of blood vessel endothelial cell migration positive regulation of catalytic activity positive regulation of cell migration positive regulation of cell motility positive regulation of cellular process positive regulation of endothelial cell migration positive regulation of epithelial cell migration positive regulation of locomotion positive regulation of molecular function positive regulation of monooxygenase activity positive regulation of nitric-oxide synthase activity positive regulation of oxidoreductase activity prenyltransferase activity primary metabolic process protein binding protein glycosylation protein mannosylation protein metabolic process protein modification process protein-containing complex regulation of biological process regulation of blood vessel endothelial cell migration regulation of catalytic activity regulation of cell migration regulation of cell motility regulation of cellular localization regulation of cellular process regulation of cholesterol transport regulation of endothelial cell migration regulation of epithelial cell migration regulation of intracellular cholesterol transport regulation of intracellular lipid transport regulation of intracellular sterol transport regulation of intracellular transport regulation of lipid localization regulation of lipid transport regulation of localization regulation of locomotion regulation of molecular function regulation of monooxygenase activity regulation of multicellular organismal process regulation of nitric-oxide synthase activity regulation of oxidoreductase activity regulation of sterol transport regulation of transport signal transduction small molecule biosynthetic process small molecule metabolic process sterol homeostasis transferase activity, transferring alkyl or aryl (other than methyl) groups transferase activity transferase complex transmembrane receptor protein tyrosine kinase signaling pathway vascular endothelial growth factor signaling pathway	GO:0001525 GO:0003674 GO:0003824 GO:0004659 GO:0005488 GO:0005515 GO:0005575 GO:0005789 GO:0006066 GO:0006486 GO:0006489 GO:0006629 GO:0006644 GO:0006720 GO:0006793 GO:0006796 GO:0006807 GO:0007165 GO:0007166 GO:0007167 GO:0007169 GO:0008150 GO:0008152 GO:0008299 GO:0008610 GO:0008654 GO:0009058 GO:0009987 GO:0010594 GO:0010595 GO:0010632 GO:0010634 GO:0016020 GO:0016093 GO:0016094 GO:0016740 GO:0016765 GO:0019348 GO:0019408 GO:0019538 GO:0019637 GO:0030154 GO:0030334 GO:0030335 GO:0031090 GO:0032368 GO:0032371 GO:0032374 GO:0032377 GO:0032380 GO:0032383 GO:0032386 GO:0032502 GO:0032768 GO:0032770 GO:0032879 GO:0032991 GO:0035268 GO:0036211 GO:0038084 GO:0040012 GO:0040017 GO:0042592 GO:0042632 GO:0043085 GO:0043167 GO:0043169 GO:0043170 GO:0043412 GO:0043413 GO:0043535 GO:0043536 GO:0044093 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0044281 GO:0044283 GO:0045547 GO:0046165 GO:0046465 GO:0046872 GO:0048518 GO:0048522 GO:0048646 GO:0048869 GO:0048878 GO:0050789 GO:0050790 GO:0050794 GO:0050999 GO:0051000 GO:0051049 GO:0051239 GO:0051341 GO:0051353 GO:0055088 GO:0055092 GO:0060341 GO:0065007 GO:0065009 GO:0070085 GO:0071704 GO:0090407 GO:0097502 GO:0110165 GO:1901564 GO:1901576 GO:1901615 GO:1901617 GO:1902494 GO:1904423 GO:1905952 GO:1990234 GO:2000145 GO:2000147
114791	tubulin gamma complex component 5	TUBGCP5	Homo sapiens (human)	9606			binding biological_process cell cycle process cell cycle cellular anatomical entity cellular component assembly cellular component organization or biogenesis cellular component organization cellular process cellular_component centrosome cytoplasmic microtubule organization cytoskeletal protein binding cytoskeleton organization cytosol equatorial microtubule organizing center gamma-tubulin binding gamma-tubulin complex gamma-tubulin ring complex meiotic cell cycle microtubule binding microtubule cytoskeleton organization microtubule minus-end binding microtubule nucleation microtubule organizing center microtubule-based process microtubule mitotic cell cycle molecular_function non-membrane-bounded organelle assembly organelle assembly organelle organization polymeric cytoskeletal fiber protein binding protein-containing complex reproductive process spindle assembly spindle organization spindle pole supramolecular complex supramolecular fiber organization supramolecular fiber supramolecular polymer tubulin binding	GO:0000226 GO:0000278 GO:0000922 GO:0000923 GO:0000930 GO:0000931 GO:0003674 GO:0005488 GO:0005515 GO:0005575 GO:0005813 GO:0005815 GO:0005829 GO:0005874 GO:0006996 GO:0007010 GO:0007017 GO:0007020 GO:0007049 GO:0007051 GO:0008017 GO:0008092 GO:0008150 GO:0009987 GO:0015631 GO:0016043 GO:0022402 GO:0022414 GO:0022607 GO:0031122 GO:0032991 GO:0043015 GO:0051011 GO:0051225 GO:0051321 GO:0070925 GO:0071840 GO:0097435 GO:0099080 GO:0099081 GO:0099512 GO:0099513 GO:0110165 GO:0140694
64478	CUB and Sushi multiple domains 1	CSMD1	Homo sapiens (human)	9606			anatomical structure development anatomical structure morphogenesis animal organ development associative learning behavior binding biological_process branching involved in mammary gland duct morphogenesis branching morphogenesis of an epithelial tube carbohydrate homeostasis cellular anatomical entity cellular_component chemical homeostasis cognition conditioned place preference developmental process involved in reproduction developmental process epithelium development female gonad development glucose homeostasis gonad development homeostatic process learning or memory learning male gonad development mammary gland branching involved in pregnancy maternal process involved in female pregnancy membrane memory molecular_function morphogenesis of a branching epithelium morphogenesis of a branching structure morphogenesis of an epithelium multicellular organismal process multicellular organismal reproductive process nervous system process neuromuscular process oviduct epithelium development protein binding reproductive process reproductive structure development response to external stimulus response to stimulus startle response system process tissue development tissue morphogenesis tube morphogenesis	GO:0001763 GO:0001964 GO:0002009 GO:0003006 GO:0003008 GO:0003674 GO:0005488 GO:0005515 GO:0005575 GO:0007610 GO:0007611 GO:0007612 GO:0007613 GO:0008150 GO:0008306 GO:0008406 GO:0008584 GO:0008585 GO:0009605 GO:0009653 GO:0009888 GO:0016020 GO:0022414 GO:0032501 GO:0032502 GO:0033500 GO:0035239 GO:0035846 GO:0042592 GO:0042593 GO:0048513 GO:0048608 GO:0048609 GO:0048729 GO:0048754 GO:0048856 GO:0048878 GO:0050877 GO:0050890 GO:0050896 GO:0050905 GO:0060135 GO:0060429 GO:0060444 GO:0060745 GO:0061138 GO:0110165 GO:1990708
284451	CIMAP1 family member D	CIMAP1D	Homo sapiens (human)	9606			binding cellular anatomical entity cellular_component cytoplasmic microtubule cytoskeleton intracellular non-membrane-bounded organelle intracellular organelle microtubule molecular_function non-membrane-bounded organelle organelle polymeric cytoskeletal fiber protein binding supramolecular complex supramolecular fiber supramolecular polymer	GO:0003674 GO:0005488 GO:0005515 GO:0005575 GO:0005856 GO:0005874 GO:0005881 GO:0043226 GO:0043228 GO:0043229 GO:0043232 GO:0099080 GO:0099081 GO:0099512 GO:0099513 GO:0110165
9252	ribosomal protein S6 kinase A5	RPS6KA5	Homo sapiens (human)	9606			ATP binding TOR signaling TORC1 signaling adenyl nucleotide binding adenyl ribonucleotide binding anion binding axon guidance binding biological regulation biological_process carbohydrate derivative binding catalytic activity, acting on a protein catalytic activity cation binding cell projection organization cell surface receptor signaling pathway cellular anatomical entity cellular component organization or biogenesis cellular component organization cellular metabolic process cellular process cellular_component chromatin organization chromatin remodeling cytokine-mediated signaling pathway cytoplasm defense response heterocyclic compound binding histone H2A kinase activity histone H2AS1 kinase activity histone H3 kinase activity histone H3S10 kinase activity histone H3S28 kinase activity histone kinase activity histone modifying activity inflammatory response interleukin-1-mediated signaling pathway intracellular membrane-bounded organelle intracellular organelle intracellular signal transduction ion binding kinase activity macromolecule metabolic process macromolecule modification magnesium ion binding membrane-bounded organelle metabolic process metal ion binding molecular_function negative regulation of DNA-templated transcription negative regulation of RNA biosynthetic process negative regulation of RNA metabolic process negative regulation of biological process negative regulation of biosynthetic process negative regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of cytokine production negative regulation of gene expression negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of multicellular organismal process negative regulation of nitrogen compound metabolic process negative regulation of nucleobase-containing compound metabolic process neuron projection development neuron projection guidance nitrogen compound metabolic process nucleoplasm nucleoside phosphate binding nucleotide binding nucleus organelle organic cyclic compound binding organic substance metabolic process organonitrogen compound metabolic process phosphate-containing compound metabolic process phosphorus metabolic process phosphorylation phosphotransferase activity, alcohol group as acceptor plasma membrane bounded cell projection organization positive regulation of CREB transcription factor activity positive regulation of DNA-binding transcription factor activity positive regulation of DNA-templated transcription positive regulation of NF-kappaB transcription factor activity positive regulation of RNA biosynthetic process positive regulation of RNA metabolic process positive regulation of biological process positive regulation of biosynthetic process positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of nitrogen compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II post-translational protein modification primary metabolic process protein binding protein kinase activity protein metabolic process protein modification process protein phosphorylation protein serine kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity protein-DNA complex organization protein-containing complex organization purine nucleotide binding purine ribonucleoside triphosphate binding purine ribonucleotide binding regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of RNA biosynthetic process regulation of RNA metabolic process regulation of biological process regulation of biosynthetic process regulation of cellular biosynthetic process regulation of cellular component organization regulation of cellular metabolic process regulation of cellular process regulation of cytokine production regulation of gene expression regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of molecular function regulation of multicellular organismal process regulation of nitrogen compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of postsynapse organization regulation of primary metabolic process regulation of synapse organization regulation of transcription by RNA polymerase II response to stimulus response to stress ribonucleotide binding signal transduction small molecule binding transferase activity, transferring phosphorus-containing groups transferase activity	GO:0000166 GO:0000287 GO:0001817 GO:0001818 GO:0003674 GO:0003824 GO:0004672 GO:0004674 GO:0004713 GO:0005488 GO:0005515 GO:0005524 GO:0005575 GO:0005634 GO:0005654 GO:0005737 GO:0006325 GO:0006338 GO:0006355 GO:0006357 GO:0006468 GO:0006793 GO:0006796 GO:0006807 GO:0006950 GO:0006952 GO:0006954 GO:0007165 GO:0007166 GO:0007411 GO:0008150 GO:0008152 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009987 GO:0010468 GO:0010556 GO:0010557 GO:0010558 GO:0010604 GO:0010605 GO:0010629 GO:0016043 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0016773 GO:0017076 GO:0019219 GO:0019221 GO:0019222 GO:0019538 GO:0030030 GO:0030554 GO:0031175 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0031929 GO:0032553 GO:0032555 GO:0032559 GO:0032793 GO:0035173 GO:0035175 GO:0035556 GO:0035639 GO:0036094 GO:0036211 GO:0038202 GO:0043167 GO:0043168 GO:0043169 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043412 GO:0043687 GO:0043933 GO:0044022 GO:0044024 GO:0044093 GO:0044237 GO:0044238 GO:0045892 GO:0045893 GO:0045934 GO:0045935 GO:0045944 GO:0046872 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0050789 GO:0050794 GO:0050807 GO:0050896 GO:0051090 GO:0051091 GO:0051092 GO:0051128 GO:0051171 GO:0051172 GO:0051173 GO:0051239 GO:0051241 GO:0051252 GO:0051253 GO:0051254 GO:0060255 GO:0065007 GO:0065009 GO:0070498 GO:0071704 GO:0071824 GO:0071840 GO:0080090 GO:0097159 GO:0097367 GO:0097485 GO:0099175 GO:0106310 GO:0110165 GO:0120036 GO:0140096 GO:0140993 GO:0140995 GO:0140996 GO:1901265 GO:1901363 GO:1901564 GO:1902679 GO:1902680 GO:2001141
3805	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	KIR2DL4	Homo sapiens (human)	9606			MHC class Ib receptor activity binding biological regulation biological_process bounding membrane of organelle cellular anatomical entity cellular defense response cellular process cellular_component cytoplasmic vesicle membrane defense response early endosome membrane endosome membrane immune receptor activity immune response-regulating signaling pathway membrane molecular transducer activity molecular_function negative regulation of biological process negative regulation of cell killing negative regulation of cellular process negative regulation of defense response negative regulation of immune effector process negative regulation of immune response negative regulation of immune system process negative regulation of innate immune response negative regulation of leukocyte mediated cytotoxicity negative regulation of leukocyte mediated immunity negative regulation of lymphocyte mediated immunity negative regulation of natural killer cell mediated cytotoxicity negative regulation of natural killer cell mediated immunity negative regulation of response to biotic stimulus negative regulation of response to external stimulus negative regulation of response to stimulus organelle membrane plasma membrane positive regulation of biological process positive regulation of biosynthetic process positive regulation of cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of cellular process positive regulation of cellular senescence positive regulation of cytokine production involved in immune response positive regulation of cytokine production positive regulation of defense response positive regulation of gene expression positive regulation of immune effector process positive regulation of immune response positive regulation of immune system process positive regulation of innate immune response positive regulation of leukocyte mediated immunity positive regulation of lymphocyte mediated immunity positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of metabolic process positive regulation of multicellular organismal process positive regulation of natural killer cell cytokine production positive regulation of natural killer cell mediated immunity positive regulation of production of molecular mediator of immune response positive regulation of response to biotic stimulus positive regulation of response to external stimulus positive regulation of response to stimulus protein binding regulation of biological process regulation of biosynthetic process regulation of cell killing regulation of cellular biosynthetic process regulation of cellular metabolic process regulation of cellular process regulation of cellular senescence regulation of cytokine production involved in immune response regulation of cytokine production regulation of defense response regulation of gene expression regulation of immune effector process regulation of immune response regulation of immune system process regulation of innate immune response regulation of leukocyte mediated cytotoxicity regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of macromolecule biosynthetic process regulation of macromolecule metabolic process regulation of metabolic process regulation of multicellular organismal process regulation of natural killer cell cytokine production regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell mediated immunity regulation of production of molecular mediator of immune response regulation of response to biotic stimulus regulation of response to external stimulus regulation of response to stimulus regulation of response to stress response to stimulus response to stress signal transduction signaling receptor activity transmembrane signaling receptor activity vesicle membrane	GO:0001817 GO:0001819 GO:0001910 GO:0001911 GO:0002682 GO:0002683 GO:0002684 GO:0002697 GO:0002698 GO:0002699 GO:0002700 GO:0002702 GO:0002703 GO:0002704 GO:0002705 GO:0002706 GO:0002707 GO:0002708 GO:0002715 GO:0002716 GO:0002717 GO:0002718 GO:0002720 GO:0002727 GO:0002729 GO:0002764 GO:0002831 GO:0002832 GO:0002833 GO:0003674 GO:0004888 GO:0005488 GO:0005515 GO:0005575 GO:0005886 GO:0006950 GO:0006952 GO:0006968 GO:0007165 GO:0008150 GO:0009889 GO:0009891 GO:0009893 GO:0009987 GO:0010008 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0012506 GO:0016020 GO:0019222 GO:0030659 GO:0031090 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0031341 GO:0031342 GO:0031347 GO:0031348 GO:0031349 GO:0031901 GO:0032101 GO:0032102 GO:0032103 GO:0032394 GO:0038023 GO:0042269 GO:0045088 GO:0045089 GO:0045824 GO:0045953 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048583 GO:0048584 GO:0048585 GO:0050776 GO:0050777 GO:0050778 GO:0050789 GO:0050794 GO:0050896 GO:0051239 GO:0051240 GO:0060089 GO:0060255 GO:0065007 GO:0080134 GO:0098588 GO:0110165 GO:0140375 GO:2000772 GO:2000774

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