GlyCosmos Portal

Displaying **all 3** entries
GO Term	Evidence Code	PMID
isocitrate dehydrogenase complex (NAD+)	IDA	16884682
mitochondrial matrix	IEA
mitochondrion	HDA IBA IDA IEA	11502169 11914276 14576278 16823961 24769239

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle enzyme complex [inference]

isocitrate dehydrogenase complex (NAD+)

oxidoreductase complex [inference]

isocitrate dehydrogenase complex (NAD+)

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
oxidoreductase activity	IEA
magnesium ion binding	IEA
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
isocitrate dehydrogenase (NAD+) activity	IEA
NAD binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NAD+) activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding

magnesium ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00030

Name

isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]

References

10601238

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
isocitrate dehydrogenase complex (NAD+)	PMID:16884682
mitochondrion	PMID:11502169 PMID:11914276 PMID:14576278 PMID:16823961 PMID:24769239

Rhea

RHEA:23632

D-threo-isocitrate + NAD⁺

CO₂ + 2-oxoglutarate + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050709	early infantile epileptic encephalopathy	Alliance of Genome Resources
DOID:0112147	retinitis pigmentosa 90	Alliance of Genome Resources
DOID:439	neuromuscular junction disease	Alliance of Genome Resources

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	172655	WB:WBGene00009664
Drosophila melanogaster	32940	FB:FBgn0027291
Drosophila melanogaster	317829	FB:FBgn0052026
Danio rerio	393926	ZFIN:ZDB-GENE-040426-1007
Xenopus tropicalis	394979	Xenbase:XB-GENE-943186
Homo sapiens	3419	HGNC:5384
Mus musculus	67834	MGI:1915084
Rattus norvegicus	114096	RGD:70889

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements