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Arachidonate 12-lipoxygenase, 12R-type

Summary

UniProt ID

O75342

Gene Symbol

ALOX12B

Organism

Homo sapiens (human)

External Links

GlyGen

O75342

PubChem

O75342

SwissLipids

SLP:000000655

The Human Metabolome Database

HMDBP03129

The O-GlcNAc Database

O75342

Annotation

Keyword

Cytoplasm
Dioxygenase
Disease variant
Fatty acid metabolism
Ichthyosis
Iron
Isomerase
Lyase
Metal-binding
Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 10** of 12 in total

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GO Term
positive regulation of mucus secretion
hepoxilin biosynthetic process
establishment of skin barrier
arachidonic acid metabolic process
linoleic acid metabolic process
protein lipidation
lipid oxidation
ceramide biosynthetic process
lipoxygenase pathway
positive regulation of MAPK cascade

Displaying **all 3** entries
GO Term
intracellular membrane-bounded organelle
cytosol
perinuclear region of cytoplasm

Displaying **all 8** entries
GO Term
arachidonate 12(R)-lipoxygenase activity
iron ion binding
linoleate 9S-lipoxygenase activity
arachidonate 8(R)-lipoxygenase activity
lyase activity
isomerase activity
arachidonate 12(S)-lipoxygenase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

Annotation information from UniProt.

Sequence

MATYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRDFATGAVGQYTVQCPQDLGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGRIYHFPAYQWMDGYETLALREATGKTTADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEWNGYIPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCKHSWKRLKDIRKIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKFPVTDDMVAPFLGEGTCLQAELEKGNIYLADYRIMEGIPTVELSGRKQHHCAPLCLLHFGPEGKMMPIAIQLSQTPGPDCPIFLPSDSEWDWLLAKTWVRYAEFYSHEAIAHLLETHLIAEAFCLALLRNLPMCHPLYKLLIPHTRYTVQINSIGRAVLLNEGGLSAKGMSLGVEGFAGVMVRALSELTYDSLYLPNDFVERGVQDLPGYYYRDDSLAVWNALEKYVTEIITYYYPSDAAVEGDPELQSWVQEIFKECLLGRESSGFPRCLRTVPELIRYVTIVIYTCSAKHAAVNTGQMEFTAWMPNFPASMRNPPIQTKGLTTLETFMDTLPDVKTTCITLLVLWTLSREPDDRRPLGHFPDIHFVEEAPRRSIEAFRQRLNQISHDIRQRNKCLPIPYYYLDPVLIENSISI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Synthesis of 12-eicosatetraenoic acid derivatives	Homo sapiens

Human Protein Atlas

ENSG00000179477

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **1 - 10** of 79 in total

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DO ID	Disease Name	Source
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050428	nonepidermolytic palmoplantar keratoderma	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060655	autosomal recessive congenital ichthyosis	DisGeNET DisGeNET
DOID:0060656	autosomal recessive congenital ichthyosis 1	DisGeNET DisGeNET DisGeNET DisGeNET DisGeNET DisGeNET
DOID:0060710	autosomal recessive congenital ichthyosis 2	DisGeNET DisGeNET DisGeNET
DOID:0060711	autosomal recessive congenital ichthyosis 3	DisGeNET
DOID:0060712	autosomal recessive congenital ichthyosis 4A	DisGeNET
DOID:0060713	autosomal recessive congenital ichthyosis 4B	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements