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MIRAGE
Serine/threonine-protein kinase PAK 3
Summary
- UniProt ID
- O75914
- Gene Symbol
-
- OPHN3
- PAK3
- Gene ID
- 5063
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O75914
- PubChem
- O75914
- The Human Metabolome Database
- HMDBP01400
- Re-Glyco
- O75914
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Allosteric enzyme
- Alternative splicing
- Cytoplasm
- Developmental protein
- Disease variant
- Intellectual disability
- Magnesium
- Metal-binding
- Phosphoprotein
- Reference proteome
- SH3-binding
- Serine/threonine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| glutamatergic synapse |
| cytoplasm |
| plasma membrane |
| cytosol |
| postsynaptic density |
Sequence
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of RAC1 | Homo sapiens |
| CD209 (DC-SIGN) signaling | Homo sapiens |
| CD28 dependent Vav1 pathway | Homo sapiens |
| CDC42 GTPase cycle | Homo sapiens |
| Ephrin signaling | Homo sapiens |
| Generation of second messenger molecules | Homo sapiens |
| MAPK6/MAPK4 signaling | Homo sapiens |
| RAC1 GTPase cycle | Homo sapiens |
| RHO GTPases activate PAKs | Homo sapiens |
| RHOJ GTPase cycle | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0112051 | non-syndromic X-linked intellectual disability 30 |
