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MIRAGE
Transforming growth factor beta-1 proprotein

Summary
UniProt ID
P01137
Gene Symbol
  • TGFB
  • TGFB1
Gene ID
7040
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011299
GlyConnect
GlyGen
P01137
PubChem
P01137
The Human Metabolome Database
HMDBP14566
RaftProt
P01137
Re-Glyco
P01137
Annotation
Keyword
  • 3D-structure
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Extracellular matrix
  • Glycoprotein
  • Growth factor
  • Mitogen
  • Reference proteome
  • Signal
Gene Ontology (GO)
Displaying entries 1 - 10 of 13 in total
GO Term
extracellular region
extracellular space
platelet alpha granule lumen
nucleus
cytoplasm
plasma membrane
axon
extracellular matrix
neuronal cell body
collagen-containing extracellular matrix
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
82 N-linked (GlcNAc...) asparagine
136 N-linked (GlcNAc...) asparagine
176 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 21 in total
Pathway Name Organism
Cell surface interactions at the vascular wall Homo sapiens
Downregulation of TGF-beta receptor signaling Homo sapiens
ECM proteoglycans Homo sapiens
Influenza Virus Induced Apoptosis Homo sapiens
Interleukin-4 and Interleukin-13 signaling Homo sapiens
Molecules associated with elastic fibres Homo sapiens
Platelet degranulation Homo sapiens
RUNX3 regulates CDKN1A transcription Homo sapiens
RUNX3 regulates p14-ARF Homo sapiens
Regulation of RUNX3 expression and activity Homo sapiens
Disease
Displaying entries 11 - 20 of 25 in total
DO ID Disease Name Source
DOID:2256 osteochondrodysplasia
DOID:234 colon adenocarcinoma
DOID:2841 asthma
DOID:3083 chronic obstructive pulmonary disease
DOID:3227 tracheal stenosis
DOID:3310 atopic dermatitis
DOID:3770 pulmonary fibrosis
DOID:4450 renal cell carcinoma
DOID:4997 Camurati-Engelmann disease
DOID:5844 myocardial infarction
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025