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Prosaposin

Summary

UniProt ID

P07602

Gene Symbol

PSAP
GLBA
SAP1

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011421

GlyConnect

1645

GlyGen

P07602

PubChem

P07602

The Human Metabolome Database

HMDBP01673

The O-GlcNAc Database

P07602

RaftProt

P07602

O-GlcNAcAtlas

P07602

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Disulfide bond
Gangliosidosis
Gaucher disease
Glycoprotein
Lysosome
Metachromatic leukodystrophy
Neurodegeneration
Parkinson disease
Parkinsonism
Reference proteome
Repeat
Secreted
Signal
Sphingolipid metabolism

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
sphingolipid metabolic process
lysosomal transport
regulation of autophagy
regulation of lipid metabolic process
prostate gland growth
epithelial cell differentiation involved in prostate gland development
positive regulation of beta-galactosidase activity
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
ganglioside GM1 transport to membrane

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GO Term
extracellular region
extracellular space
lysosome
lysosomal membrane
plasma membrane
intracellular membrane-bounded organelle
collagen-containing extracellular matrix
azurophil granule membrane
extracellular exosome
late endosome

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GO Term
protease binding
enzyme activator activity
identical protein binding
protein homodimerization activity
phospholipid binding
scaffold protein binding
ganglioside GM1 binding
ganglioside GM2 binding
ganglioside GM3 binding
ganglioside GT1b binding

Site Annotations

Displaying 1 entry
Position	Description
215	Not glycosylated; in variant MLDSAPB Ile-217

Annotation information from UniProt.

Sequence

MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **21 - 23** of 23 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
426	N-linked (GlcNAc...) asparagine	19159218 19167329	G40834TG G37412TK G54612UD G63041LO G62894KT G11870QZ G36191CD G72735IY G05724UK G33609NS G39188ZX G41247ZX G80966KZ G25637MV G06110VR G00406II G74724QE G82348BZ G14669DU	GlycoProtDB UniProt GlyGen GlyConnect
427			G49108TO	GlyGen The O-GlcNAc Database
			G63889NK G90093AU G18938DW G47012YE G45359RY G72797UR G86357DX G20425TQ G29857RC G79809MM G26145IL G45187EI G54702KT G61792ET G91636VS G04483SK G07695ZT G23863VK G42264OV G52428MJ G78059CC G14260UH G20030CU G93500PH G23432EQ G43299SD G10256JP G61207RZ G00986YT G03216SJ G28347RJ G36191CD G43664YB G50045TK G31936TA G34527RW G59471TH G11254FL G25381UC G61330YQ G66937TJ G81295CK G81397LO G83006TR G89993FE G49874UX G80858MF G04744XB G12398HZ G29880MM G33734YD G61334IA G39188ZX G80966KZ G30633FJ G39213VZ G42679AH G98140IX G23453IV G28663KH G39602UU G56269EA G69411IG G11994QC G45036WQ G61884GF G94854LT G06110VR G55220VL G29905OR G60145BJ G64481DJ G85041WE G96771UL G09724ZC G66538GV G74724QE G82348BZ G10756ZZ G14669DU G22768VO G00395TQ G31685JQ G22573RC G63628AV G22355FZ G32152BH G15407YE G32550BI G42666HT G71838YU G64581RP	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
G alpha (i) signalling events	Homo sapiens
Glycosphingolipid catabolism	Homo sapiens
Neutrophil degranulation	Homo sapiens
Peptide ligand-binding receptors	Homo sapiens
Platelet degranulation	Homo sapiens

Human Protein Atlas

ENSG00000197746

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **41 - 50** of **265** in total

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DO ID	Disease Name	Source
DOID:0110483	autosomal recessive nonsyndromic deafness 25	DisGeNET
DOID:0110484	autosomal recessive nonsyndromic deafness 26	DisGeNET
DOID:0110485	autosomal recessive nonsyndromic deafness 27	DisGeNET
DOID:0110486	autosomal recessive nonsyndromic deafness 28	DisGeNET
DOID:0110487	autosomal recessive nonsyndromic deafness 29	DisGeNET
DOID:0110488	autosomal recessive nonsyndromic deafness 3	DisGeNET
DOID:0110489	autosomal recessive nonsyndromic deafness 30	DisGeNET
DOID:0110490	autosomal recessive nonsyndromic deafness 31	DisGeNET
DOID:0110491	autosomal recessive nonsyndromic deafness 32	DisGeNET
DOID:0110492	autosomal recessive nonsyndromic deafness 33	DisGeNET

GlyTouCan

GlyComb

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UniCarb-DR

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International Collaboration

Acknowledgements