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Interleukin-1 receptor type 1

Summary

UniProt ID

P14778

Gene Symbol

IL1R1
IL1R
IL1RA
IL1RT1

Organism

Homo sapiens (human)

External Links

GlyGen: P14778
PubChem: P14778
The Human Metabolome Database: HMDBP12410

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Immunoglobulin domain
Inflammatory response
NAD
Phosphoprotein
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
inflammatory response
immune response
cell surface receptor signaling pathway
regulation of inflammatory response
positive regulation of type II interferon production
positive regulation of T-helper 1 cell cytokine production
positive regulation of neutrophil extravasation
positive regulation of interleukin-1-mediated signaling pathway
interleukin-1-mediated signaling pathway
response to interleukin-1

Displaying **all 4** entries
GO Term
extracellular region
plasma membrane
membrane
external side of plasma membrane

Displaying **all 8** entries
GO Term
protease binding
transmembrane signaling receptor activity
NAD+ nucleotidase, cyclic ADP-ribose generating
NAD+ nucleosidase activity
interleukin-1 receptor activity
interleukin-1, type I, activating receptor activity
interleukin-1 binding
platelet-derived growth factor receptor binding

Annotation information from UniProt.

Sequence

MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHVPLG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	GlyTouCan ID	Source
100	N-linked (GlcNAc...) asparagine		UniProt GlyGen
193	N-linked (GlcNAc...) asparagine	G80920RR	UniProt GlyGen
233	N-linked (GlcNAc...) asparagine		UniProt GlyGen
249	N-linked (GlcNAc...) asparagine		UniProt GlyGen
263	N-linked (GlcNAc...) asparagine		UniProt GlyGen
297	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Interleukin-1 signaling	Homo sapiens
Interleukin-10 signaling	Homo sapiens
Potential therapeutics for SARS	Homo sapiens

Disease

Displaying entries **41 - 50** of **229** in total

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DO ID	Disease Name	Source
DOID:0110750	type 1 diabetes mellitus 11	DisGeNET
DOID:0110751	type 1 diabetes mellitus 12	DisGeNET
DOID:0110752	type 1 diabetes mellitus 13	DisGeNET
DOID:0110753	type 1 diabetes mellitus 15	DisGeNET
DOID:0110754	type 1 diabetes mellitus 17	DisGeNET
DOID:0110755	type 1 diabetes mellitus 18	DisGeNET
DOID:0110756	type 1 diabetes mellitus 19	DisGeNET
DOID:0110757	type 1 diabetes mellitus 20	DisGeNET
DOID:0110758	type 1 diabetes mellitus 21	DisGeNET
DOID:0110759	type 1 diabetes mellitus 22	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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External Links

Annotation

International Collaboration

Acknowledgements