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Tyrosine-protein phosphatase non-receptor type 11

Summary

UniProt ID

P35235

Gene Symbol

Ptpn11

Gene ID

19247

Organism

Mus musculus (house mouse)

External Links

GlyGen: P35235
PubChem: P35235
Re-Glyco: P35235

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Phosphoprotein
Protein phosphatase
Reference proteome
Repeat
SH2 domain

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
nucleus
cytoplasm
protein-containing complex
cytosol

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
integrin-mediated signaling pathway
negative regulation of growth hormone secretion
lipid metabolic process
signal transduction
positive regulation of signal transduction
organ growth
hormone metabolic process
glucose homeostasis
positive regulation of ossification
positive regulation of mitotic cell cycle

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GO Term
phosphotyrosine residue binding
non-membrane spanning protein tyrosine phosphatase activity
peptide hormone receptor binding
protein tyrosine phosphatase activity
insulin receptor binding
protein kinase binding
receptor tyrosine kinase binding
cadherin binding
cell adhesion molecule binding
phosphoprotein phosphatase activity

Annotation information from UniProt.

Sequence

MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLVDQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQRSFR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
217			G41840AI	GlyGen
566				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **11 - 20** of 37 in total

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Pathway Name	Organism
Interleukin-20 family signaling	Mus musculus
Interleukin-3, Interleukin-5 and GM-CSF signaling	Mus musculus
Interleukin-6 signaling	Mus musculus
MAPK1 (ERK2) activation	Mus musculus
MAPK3 (ERK1) activation	Mus musculus
MET activates PTPN11	Mus musculus
Negative regulation of FGFR1 signaling	Mus musculus
Negative regulation of FGFR2 signaling	Mus musculus
Negative regulation of FGFR3 signaling	Mus musculus
Negative regulation of FGFR4 signaling	Mus musculus

Disease

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	Alliance of Genome Resources
DOID:0050458	juvenile myelomonocytic leukemia	Alliance of Genome Resources
DOID:0050868	hepatocellular adenoma	Alliance of Genome Resources
DOID:0060250	idiopathic scoliosis	Alliance of Genome Resources
DOID:0060578	Noonan syndrome 1	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:14291	Noonan syndrome with multiple lentigines	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements