GlyCosmos Portal

Submissions

Fatty acid synthase

Summary

UniProt ID

P49327

Gene Symbol

FASN
FAS

Organism

Homo sapiens (human)

External Links

GlyGen

P49327

PubChem

P49327

SwissLipids

SLP:000000765

The Human Metabolome Database

HMDBP00035

The O-GlcNAc Database

P49327

RaftProt

P49327

O-GlcNAcAtlas

P49327

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Fatty acid biosynthesis
Hydrolase
Isopeptide bond
Lyase
Multifunctional enzyme
NAD
NADP
Oxidoreductase
Phosphopantetheine
Phosphoprotein
Pyridoxal phosphate
Reference proteome
S-nitrosylation
Transferase
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 12 in total

1

2

Next ›

Last »
GO Term
neutrophil differentiation
monocyte differentiation
mammary gland development
modulation by host of viral process
ether lipid biosynthetic process
osteoblast differentiation
glandular epithelial cell development
fatty acid metabolic process
fatty acid biosynthetic process
inflammatory response

Displaying **all 8** entries
GO Term
glycogen granule
melanosome
extracellular exosome
cytosol
cytoplasm
Golgi apparatus
plasma membrane
membrane

Displaying entries **1 - 10** of 15 in total

1

2

Next ›

Last »
GO Term
RNA binding
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
cadherin binding
phosphopantetheine binding
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
(3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity
(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
fatty acid synthase activity
[acyl-carrier-protein] S-acetyltransferase activity

Annotation information from UniProt.

Sequence

MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGPEVQQVPAGERPLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	GlyTouCan ID	Source
195	G32392SM	GlyGen
315	G49108TO	GlyGen The O-GlcNAc Database
806	G49108TO	GlyGen The O-GlcNAc Database
980	G49108TO	GlyGen The O-GlcNAc Database
1534	G49108TO	GlyGen The O-GlcNAc Database
1945	G36379GD	GlyGen
1982	G72065MN	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Activation of gene expression by SREBF (SREBP)	Homo sapiens
ChREBP activates metabolic gene expression	Homo sapiens
Fatty acyl-CoA biosynthesis	Homo sapiens
LXRs regulate gene expression linked to lipogenesis	Homo sapiens
Vitamin B5 (pantothenate) metabolism	Homo sapiens

Human Protein Atlas

ENSG00000169710

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **91 - 100** of **298** in total

« First

‹ Prev

…

6

7

8

9

10

11

12

13

14

…

Next ›

Last »
DO ID	Disease Name	Source
DOID:0110754	type 1 diabetes mellitus 17	DisGeNET
DOID:0110755	type 1 diabetes mellitus 18	DisGeNET
DOID:0110756	type 1 diabetes mellitus 19	DisGeNET
DOID:0110757	type 1 diabetes mellitus 20	DisGeNET
DOID:0110758	type 1 diabetes mellitus 21	DisGeNET
DOID:0110759	type 1 diabetes mellitus 22	DisGeNET
DOID:0110760	type 1 diabetes mellitus 23	DisGeNET
DOID:0110761	type 1 diabetes mellitus 24	DisGeNET
DOID:0110860	polycystic kidney disease 3	DisGeNET
DOID:0110892	inflammatory bowel disease 1	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

International Collaboration

Acknowledgements