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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
5'-AMP-activated protein kinase catalytic subunit alpha-2
Summary
- UniProt ID
- P54646
- Gene Symbol
-
- PRKAA2
- AMPK
- AMPK2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Autophagy
- Biological rhythms
- Cholesterol biosynthesis
- Chromatin regulator
- Cytoplasm
- Fatty acid biosynthesis
- Magnesium
- Metal-binding
- Nucleus
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Transcription regulation
- Ubl conjugation
- Wnt signaling pathway
- Gene Ontology (GO)
| GO Term |
|---|
| protein phosphorylation |
| fatty acid biosynthetic process |
| autophagy |
| signal transduction |
| lipid biosynthetic process |
| negative regulation of gene expression |
| glucose homeostasis |
| GO Term |
|---|
| nucleus |
| cytoplasm |
| Golgi apparatus |
| axon |
| dendrite |
| neuronal cell body |
| nuclear speck |
| nucleotide-activated protein kinase complex |
| cytosol |
| nucleoplasm |
| GO Term |
|---|
| histone H2BS36 kinase activity |
Sequence
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 388 |
|
|||
|
|
G47012YE
G00912UN
G48414YA
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| AMPK inhibits chREBP transcriptional activation activity | Homo sapiens |
| Activation of AMPK downstream of NMDARs | Homo sapiens |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | Homo sapiens |
| Carnitine metabolism | Homo sapiens |
| Energy dependent regulation of mTOR by LKB1-AMPK | Homo sapiens |
| Lipophagy | Homo sapiens |
| Macroautophagy | Homo sapiens |
| Nuclear events mediated by NFE2L2 | Homo sapiens |
| Regulation of TP53 Activity through Phosphorylation | Homo sapiens |
| TP53 Regulates Metabolic Genes | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110286 | obsolete autosomal recessive limb-girdle muscular dystrophy type 2R | |
| DOID:0110287 | autosomal recessive limb-girdle muscular dystrophy type 2S | |
| DOID:0110289 | autosomal recessive limb-girdle muscular dystrophy type 2Y | |
| DOID:0110292 | autosomal recessive limb-girdle muscular dystrophy type 2O | |
| DOID:0110293 | autosomal recessive limb-girdle muscular dystrophy type 2P | |
| DOID:0110294 | autosomal recessive limb-girdle muscular dystrophy type 2T | |
| DOID:0110295 | autosomal recessive limb-girdle muscular dystrophy type 2U | |
| DOID:0110296 | autosomal recessive limb-girdle muscular dystrophy type 2M | |
| DOID:0110297 | autosomal recessive limb-girdle muscular dystrophy type 2K | |
| DOID:0110298 | autosomal recessive limb-girdle muscular dystrophy type 2N |
