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MIRAGE
Toll-like receptor 9
Summary
- UniProt ID
- Q9NR96
- Gene Symbol
-
- TLR9
- UNQ5798/PRO19605
- Gene ID
- 54106
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9NR96
- PubChem
- Q9NR96
- The Human Metabolome Database
- HMDBP02761
- Re-Glyco
- Q9NR96
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cytoplasmic vesicle
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Golgi apparatus
- Inflammatory response
- Innate immunity
- Leucine-rich repeat
- Lysosome
- Palmitate
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| cytoplasm |
| lysosome |
| plasma membrane |
| Golgi membrane |
| endosome |
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| basolateral plasma membrane |
| apical plasma membrane |
| GO Term |
|---|
| protein homodimerization activity |
| siRNA binding |
| unmethylated CpG binding |
| pattern recognition receptor activity |
| interleukin-1 receptor binding |
Sequence
MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 513 | N-linked (GlcNAc...) asparagine |
|
||
| 567 | N-linked (GlcNAc...) asparagine |
|
||
| 694 | N-linked (GlcNAc...) asparagine | |||
| 731 | N-linked (GlcNAc...) asparagine |
G80920RR
G62765YT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| MyD88 dependent cascade initiated on endosome | Homo sapiens |
| PI3K Cascade | Homo sapiens |
| Potential therapeutics for SARS | Homo sapiens |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | Homo sapiens |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | Homo sapiens |
| Toll Like Receptor 9 (TLR9) Cascade | Homo sapiens |
| Trafficking and processing of endosomal TLR | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080162 | lupus nephritis | |
| DOID:10533 | viral pneumonia | |
| DOID:1287 | cardiovascular system disease | |
| DOID:13166 | allergic bronchopulmonary aspergillosis | |
| DOID:1485 | cystic fibrosis | |
| DOID:1883 | hepatitis C | |
| DOID:2043 | hepatitis B | |
| DOID:2799 | bronchiolitis obliterans | |
| DOID:2841 | asthma | |
| DOID:2957 | pulmonary tuberculosis |
