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Retinal guanylyl cyclase 1

Summary

UniProt ID

Q02846

Gene Symbol

CORD6
GUC1A4
GUC2D
GUCY2D
RETGC
RETGC1

Gene ID

3000

Organism

Homo sapiens (human)

External Links

GlyGen: Q02846
PubChem: Q02846
The Human Metabolome Database: HMDBP01067
The O-GlcNAc Database: Q02846
Re-Glyco: Q02846

Annotation

Keyword

Cell projection
Cone-rod dystrophy
Congenital stationary night blindness
Disease variant
Disulfide bond
Endoplasmic reticulum
GTP-binding
Glycoprotein
Leber congenital amaurosis
Lyase
Reference proteome
Signal
Transmembrane helix
Vision
cGMP biosynthesis

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
plasma membrane
endoplasmic reticulum membrane
photoreceptor outer segment
nuclear outer membrane
photoreceptor outer segment membrane
photoreceptor disc membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 5** entries
GO Term
visual perception
regulation of rhodopsin mediated signaling pathway
cGMP biosynthetic process
receptor guanylyl cyclase signaling pathway
cGMP-mediated signaling

Displaying **all 8** entries
GO Term
protein homodimerization activity
protein-containing complex binding
signaling receptor activity
GTP binding
peptide receptor activity
guanylate cyclase activity
protein kinase activity
ATP binding

Annotation information from UniProt.

Sequence

MTACARRAGGLPDPGLCGPAWWAPSLPRLPRALPRLPLLLLLLLLQPPALSAVFTVGVLGPWACDPIFSRARPDLAARLAAARLNRDPGLAGGPRFEVALLPEPCRTPGSLGAVSSALARVSGLVGPVNPAACRPAELLAEEAGIALVPWGCPWTQAEGTTAPAVTPAADALYALLRAFGWARVALVTAPQDLWVEAGRSLSTALRARGLPVASVTSMEPLDLSGAREALRKVRDGPRVTAVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTIHYALSPGPEALAALANSSQLRRAHDAVLTLTRHCPSEGSVLDSLRRAQERRELPSDLNLQQVSPLFGTIYDAVFLLARGVAEARAAAGGRWVSGAAVARHIRDAQVPGFCGDLGGDEEPPFVLLDTDAAGDRLFATYMLDPARGSFLSAGTRMHFPRGGSAPGPDPSCWFDPNNICGGGLEPGLVFLGFLLVVGMGLAGAFLAHYVRHRLLHMQMVSGPNKIILTVDDITFLHPHGGTSRKVAQGSRSSLGARSMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPGSSNHGISLQEIPPERRRKLEKARPGQFS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	GlyTouCan ID	Source
166			GlyGen
297	N-linked (GlcNAc...) asparagine		UniProt GlyGen
926		G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Inactivation, recovery and regulation of the phototransduction cascade	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050534	congenital stationary night blindness	Alliance of Genome Resources
DOID:0110078	Leber congenital amaurosis 1	Alliance of Genome Resources
DOID:0111011	cone-rod dystrophy 6	Alliance of Genome Resources
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources
DOID:980	choroidal sclerosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements