GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels ▲	GO IDs
GL_000198	C-type lectin domain family 7 member A	Q6QLQ4	Mus musculus	10090	(1->3)-beta-D-glucan binding (1->3)-beta-D-glucan immune receptor activity antifungal innate immune response carbohydrate binding cell activation cell recognition cell surface cell surface pattern recognition receptor signaling pathway cell-cell adhesion cellular response to molecule of fungal origin cytoplasm detection of fungus detection of molecule of fungal origin detection of yeast external side of plasma membrane identical protein binding inflammatory response innate immune response leukocyte activation involved in immune response metal ion binding opsonin binding pattern recognition receptor activity phagocytosis, engulfment phagocytosis, recognition plasma membrane polysaccharide binding positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of T-helper 17 type immune response positive regulation of calcium-mediated signaling positive regulation of canonical NF-kappaB signal transduction positive regulation of cell maturation positive regulation of cell migration positive regulation of cell population proliferation positive regulation of cytokine production involved in immune response positive regulation of cytokine production involved in inflammatory response positive regulation of dendritic cell cytokine production positive regulation of gene expression positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-2 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of killing of cells of another organism positive regulation of lymphocyte activation positive regulation of monocyte chemotactic protein-1 production positive regulation of nitric oxide biosynthetic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis positive regulation of protein-containing complex assembly positive regulation of respiratory burst positive regulation of stress-activated MAPK cascade positive regulation of superoxide anion generation positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of wound healing regulation of calcineurin-NFAT signaling cascade regulation of canonical NF-kappaB signal transduction response to molecule of fungal origin response to yeast stimulatory C-type lectin receptor signaling pathway	GO:0001775 GO:0001846 GO:0001872 GO:0001874 GO:0001878 GO:0001879 GO:0002223 GO:0002238 GO:0002366 GO:0002720 GO:0002732 GO:0002752 GO:0005737 GO:0005886 GO:0006910 GO:0006911 GO:0006954 GO:0008037 GO:0008284 GO:0009897 GO:0009986 GO:0010628 GO:0016046 GO:0030246 GO:0030247 GO:0030335 GO:0031334 GO:0032491 GO:0032729 GO:0032731 GO:0032733 GO:0032735 GO:0032743 GO:0032747 GO:0032755 GO:0032757 GO:0032760 GO:0032874 GO:0032930 GO:0038187 GO:0042802 GO:0043122 GO:0043123 GO:0045087 GO:0045429 GO:0046872 GO:0050731 GO:0050766 GO:0050850 GO:0051091 GO:0051092 GO:0051251 GO:0051712 GO:0060267 GO:0061760 GO:0070884 GO:0071226 GO:0071639 GO:0090303 GO:0098609 GO:1900017 GO:1903431 GO:2000318
GL_002401	CD209 antigen-like protein B	Q8CJ91	Mus musculus	10090	(1->3)-beta-D-glucan binding B cell adhesion calcium-dependent protein binding detection of bacterium detection of yeast endocytosis external side of plasma membrane immune response mannose binding membrane metal ion binding phagocytosis, recognition plasma membrane polysaccharide binding positive regulation of T cell proliferation positive regulation of phagocytosis positive regulation of tumor necrosis factor production positive regulation of viral life cycle viral entry into host cell virus receptor activity	GO:0001618 GO:0001872 GO:0001879 GO:0005537 GO:0005886 GO:0006897 GO:0006910 GO:0006955 GO:0009897 GO:0016020 GO:0016045 GO:0030247 GO:0032760 GO:0042102 GO:0046718 GO:0046872 GO:0048306 GO:0050766 GO:0097323 GO:1903902
GL_000197	C-type lectin domain family 7 member A	Q9BXN2	Homo sapiens	9606	(1->3)-beta-D-glucan binding MHC protein binding T cell activation antifungal innate immune response carbohydrate binding carbohydrate mediated signaling cell activation cell recognition cell surface cellular response to molecule of fungal origin cytoplasm defense response to protozoan detection of fungus detection of molecule of fungal origin detection of yeast identical protein binding inflammatory response membrane metal ion binding pattern recognition receptor activity phagocytosis, recognition plasma membrane positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of T-helper 17 type immune response positive regulation of calcium-mediated signaling positive regulation of canonical NF-kappaB signal transduction positive regulation of cell maturation positive regulation of cell migration positive regulation of cell population proliferation positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cytokine production involved in inflammatory response positive regulation of dendritic cell cytokine production positive regulation of gene expression positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-2 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of killing of cells of another organism positive regulation of lymphocyte activation positive regulation of monocyte chemotactic protein-1 production positive regulation of nitric oxide biosynthetic process positive regulation of phagocytosis positive regulation of protein-containing complex assembly positive regulation of respiratory burst positive regulation of superoxide anion generation positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of wound healing regulation of calcineurin-NFAT signaling cascade regulation of canonical NF-kappaB signal transduction response to yeast stimulatory C-type lectin receptor signaling pathway	GO:0001775 GO:0001872 GO:0001878 GO:0001879 GO:0002223 GO:0002732 GO:0005737 GO:0005886 GO:0006910 GO:0006954 GO:0008037 GO:0008284 GO:0009756 GO:0009986 GO:0010628 GO:0016020 GO:0016046 GO:0030246 GO:0030335 GO:0031334 GO:0032491 GO:0032729 GO:0032731 GO:0032733 GO:0032735 GO:0032743 GO:0032747 GO:0032755 GO:0032757 GO:0032760 GO:0032930 GO:0038187 GO:0042110 GO:0042287 GO:0042802 GO:0042832 GO:0043122 GO:0043123 GO:0043280 GO:0045429 GO:0046872 GO:0050766 GO:0050850 GO:0051091 GO:0051092 GO:0051251 GO:0051712 GO:0060267 GO:0061760 GO:0070884 GO:0071226 GO:0071639 GO:0090303 GO:1900017 GO:1903431 GO:2000318
GL_001995	C-type lectin domain family 7 member A	Q8HZR8	Macaca mulatta	9544	(1->3)-beta-D-glucan binding antifungal innate immune response cell surface cellular response to molecule of fungal origin detection of fungus detection of molecule of fungal origin inflammatory response metal ion binding pattern recognition receptor activity phagocytosis, recognition plasma membrane positive regulation of T-helper 17 type immune response positive regulation of canonical NF-kappaB signal transduction positive regulation of cell migration positive regulation of cell population proliferation positive regulation of cytokine production involved in inflammatory response positive regulation of killing of cells of another organism positive regulation of lymphocyte activation positive regulation of phagocytosis positive regulation of wound healing	GO:0001872 GO:0005886 GO:0006910 GO:0006954 GO:0008284 GO:0009986 GO:0016046 GO:0030335 GO:0032491 GO:0038187 GO:0043123 GO:0046872 GO:0050766 GO:0051251 GO:0051712 GO:0061760 GO:0071226 GO:0090303 GO:1900017 GO:2000318
GL_001994	C-type lectin domain family 7 member A	Q49BZ4	Bos taurus	9913	(1->3)-beta-D-glucan binding antifungal innate immune response cell surface cellular response to molecule of fungal origin detection of fungus detection of molecule of fungal origin inflammatory response metal ion binding pattern recognition receptor activity phagocytosis, recognition plasma membrane positive regulation of T-helper 17 type immune response positive regulation of canonical NF-kappaB signal transduction positive regulation of cell migration positive regulation of cell population proliferation positive regulation of cytokine production involved in inflammatory response positive regulation of killing of cells of another organism positive regulation of lymphocyte activation positive regulation of phagocytosis positive regulation of wound healing	GO:0001872 GO:0005886 GO:0006910 GO:0006954 GO:0008284 GO:0009986 GO:0016046 GO:0030335 GO:0032491 GO:0038187 GO:0043123 GO:0046872 GO:0050766 GO:0051251 GO:0051712 GO:0061760 GO:0071226 GO:0090303 GO:1900017 GO:2000318
GL_002359	Pentraxin-related protein PTX3	P26022	Homo sapiens	9606	(1->3)-beta-D-glucan binding complement component C1q complex binding extracellular matrix extracellular matrix organization extracellular region extracellular space identical protein binding inflammatory response innate immune response negative regulation by host of viral exo-alpha-sialidase activity negative regulation by host of viral glycoprotein metabolic process negative regulation by host of viral process negative regulation of exo-alpha-sialidase activity negative regulation of glycoprotein metabolic process negative regulation of viral entry into host cell opsonization ovarian cumulus expansion positive regulation of nitric oxide biosynthetic process positive regulation of phagocytosis response to yeast specific granule lumen tertiary granule lumen virion binding	GO:0001550 GO:0001849 GO:0001872 GO:0001878 GO:0005576 GO:0005615 GO:0006954 GO:0008228 GO:0030198 GO:0031012 GO:0035580 GO:0042802 GO:0044793 GO:0044869 GO:0044871 GO:0045087 GO:0045429 GO:0046597 GO:0046790 GO:0050766 GO:1903016 GO:1903019 GO:1904724
GL_001832	Secreted beta-glucosidase sun1	Q4WGL5	Aspergillus fumigatus Af293	330879	(1->3)-beta-D-glucan catabolic process carbohydrate binding cell surface extracellular region fungal-type cell wall fungal-type cell wall organization hydrolase activity, acting on glycosyl bonds hyphal growth	GO:0005576 GO:0006076 GO:0009277 GO:0009986 GO:0016798 GO:0030246 GO:0030448 GO:0031505
GL_001835	Sorbitol dehydrogenase	Q00796	Homo sapiens	9606	(R,R)-butanediol dehydrogenase activity D-sorbitol dehydrogenase (acceptor) activity D-xylulose reductase activity L-iditol 2-dehydrogenase activity L-xylitol catabolic process L-xylitol metabolic process NAD binding carbohydrate binding cytosol extracellular exosome extracellular space flagellated sperm motility fructose biosynthetic process glucose metabolic process glucuronate catabolic process to xylulose 5-phosphate identical protein binding membrane mitochondrial membrane motile cilium ribitol 2-dehydrogenase activity sorbitol catabolic process zinc ion binding	GO:0000721 GO:0003939 GO:0005615 GO:0005829 GO:0006006 GO:0006062 GO:0008270 GO:0016020 GO:0019640 GO:0030246 GO:0030317 GO:0031514 GO:0031966 GO:0042802 GO:0046370 GO:0046526 GO:0047833 GO:0050255 GO:0051160 GO:0051164 GO:0051287 GO:0070062
GL_001183	1,4-alpha-glucan-branching enzyme	Q04446	Homo sapiens	9606	1,4-alpha-glucan branching enzyme activity 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) carbohydrate binding cation binding cytoplasm cytosol extracellular exosome generation of precursor metabolites and energy glycogen biosynthetic process glycogen metabolic process hydrolase activity, hydrolyzing O-glycosyl compounds negative regulation of neuron apoptotic process	GO:0003844 GO:0004553 GO:0005737 GO:0005829 GO:0005977 GO:0005978 GO:0006091 GO:0030246 GO:0043169 GO:0043524 GO:0070062 GO:0102752
GL_001184	1,4-alpha-glucan-branching enzyme	Q9D6Y9	Mus musculus	10090	1,4-alpha-glucan branching enzyme activity 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) carbohydrate binding cation binding cytoplasm cytosol glycogen biosynthetic process hydrolase activity, hydrolyzing O-glycosyl compounds negative regulation of neuron apoptotic process	GO:0003844 GO:0004553 GO:0005737 GO:0005829 GO:0005978 GO:0030246 GO:0043169 GO:0043524 GO:0102752