Activation and oligomerization of BAK protein
|
|
|
|
|
Activation of BID and translocation to mitochondria
|
|
|
- BID
- CASP8
- CGL1
- CSPB
- CTLA1
- GRB
- GZMB
- MCH5
- NMT
- NMT1
|
|
Downregulation of TGF-beta receptor signaling
|
|
|
- ALK5
- BAMBI
- CHIP
- CRM1
- GADD34
- KIAA0439
- KIAA0529
- KIAA0647
- KIAA1625
- MADH2
- MADH3
- MADH7
- MADH8
- MADR2
- MAWD
- MTMR4
- NEDD4L
- NEDL3
- NMA
- PMEPA1
- PPP1A
- PPP1CA
- PPP1CB
- PPP1CC
- PPP1R15A
- RPS27A
- SKR4
- SMAD2
- SMAD3
- SMAD7
- SMURF1
- SMURF2
- STAG1
- STRAP
- STUB1
- TGFB
- TGFB1
- TGFBR1
- TGFBR2
- TMEPAI
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UCH37
- UCHL5
- UNRIP
- USP15
- XPO1
- ZFYVE11
|
|
Antimicrobial peptides
|
|
|
- AIDD
- APOJ
- BPI
- BPIFA1
- BPIFA2
- BPIFB1
- BPIFB2
- BPIFB4
- BPIFB6
- BPIL1
- BPIL3
- C20orf114
- C20orf184
- C20orf186
- C20orf70
- CAMP
- CAP18
- CHGA
- CLI
- CLU
- CTSG
- DCD
- DSEP
- ECP
- ELA2
- ELANE
- EPPIN
- FALL39
- GIG12
- GNLY
- HIP
- HIS1
- HIS2
- HS71
- HSP70
- HTN1
- HTN3
- INTL
- ITLN
- ITLN1
- KUB1
- LAG2
- LEAP2
- LF
- LFR
- LPLUNC1
- LPLUNC2
- LPLUNC4
- LTF
- LUNX
- LYZ
- LZM
- MBN
- NASG
- NKG5
- PAP
- PAP1
- PAP1B
- PGLYRP
- PGLYRP1
- PGLYRP2
- PGLYRP3
- PGLYRP4
- PGLYRPL
- PGRP
- PGRPIA
- PGRPIB
- PGRPL
- PI3
- PLA2B
- PLA2G2A
- PLA2L
- PLUNC
- PRSS2
- PRSS3
- PRSS4
- PRTN3
- RASF-A
- REG3A
- REG3G
- RNASE3
- RNASE6
- RNASE7
- RNASE8
- RNS3
- RNS6
- SEMG
- SEMG1
- SPINLW1
- SPLUNC1
- SPLUNC2
- SPURT
- SSA1
- SSA2
- SSA4
- TLA519
- TNFSF3L
- TRY2
- TRY3
- TRY4
- TRYP2
- WAP3
- WAP7
- WFDC14
- WFDC7
|
|
Nonhomologous End-Joining (NHEJ)
|
|
|
- ABRA1
- ABRAXAS1
- ARTEMIS
- ASCID
- ATM
- BABAM1
- BABAM2
- BARD1
- BLU
- BRCA1
- BRCC3
- BRCC36
- BRCC45
- BRE
- C19orf62
- C6.1A
- CCDC98
- CXorf53
- DCLRE1C
- EAP2
- FAM175A
- G22P1
- G22P2
- H2AFX
- H2AX
- H2BC1
- H2BC10
- H2BC11
- H2BC12
- H2BC12L
- H2BC13
- H2BC14
- H2BC15
- H2BC17
- H2BC21
- H2BC26
- H2BC3
- H2BC4
- H2BC5
- H2BC6
- H2BC7
- H2BC8
- H2BC9
- H2BFA
- H2BFB
- H2BFC
- H2BFD
- H2BFE
- H2BFF
- H2BFG
- H2BFH
- H2BFJ
- H2BFK
- H2BFL
- H2BFN
- H2BFQ
- H2BFR
- H2BFS
- H2BFT
- H2BS1
- H2BU1
- H3-4
- H3FT
- H4-16
- H4/A
- H4/B
- H4/C
- H4/D
- H4/E
- H4/G
- H4/H
- H4/I
- H4/J
- H4/K
- H4/M
- H4/N
- H4/O
- H4C1
- H4C11
- H4C12
- H4C13
- H4C14
- H4C15
- H4C16
- H4C2
- H4C3
- H4C4
- H4C5
- H4C6
- H4C8
- H4C9
- H4F2
- H4FA
- H4FB
- H4FC
- H4FD
- H4FE
- H4FG
- H4FH
- H4FI
- H4FJ
- H4FK
- H4FM
- H4FN
- H4FO
- HERC2
- HIRIP1
- HIRIP2
- HIST1H2BA
- HIST1H2BB
- HIST1H2BC
- HIST1H2BD
- HIST1H2BE
- HIST1H2BF
- HIST1H2BG
- HIST1H2BH
- HIST1H2BI
- HIST1H2BJ
- HIST1H2BK
- HIST1H2BL
- HIST1H2BM
- HIST1H2BN
- HIST1H2BO
- HIST1H4A
- HIST1H4B
- HIST1H4C
- HIST1H4D
- HIST1H4E
- HIST1H4F
- HIST1H4H
- HIST1H4I
- HIST1H4J
- HIST1H4K
- HIST1H4L
- HIST2H2BE
- HIST2H4
- HIST2H4A
- HIST2H4B
- HIST3H2BB
- HIST3H3
- HIST4H4
- HNGS1
- HTATIP
- HYRC
- HYRC1
- KAT5
- KIAA0170
- KIAA0646
- KIAA1090
- LIG4
- MDC1
- MERIT40
- MMS2
- MMSET
- MRE11
- MRE11A
- NBA1
- NBN
- NBS
- NBS1
- NFBD1
- NHEJ1
- NSD2
- P95
- PAXIP1
- PAXIP1L
- PIAS4
- PIASG
- POLL
- POLM
- PRKDC
- PTIP
- RAD50
- RAP80
- RIF1
- RNF168
- RNF53
- RNF8
- RXRIP110
- SCIDA
- SNM1C
- TDP1
- TDP2
- TIP60
- TP53BP1
- TRX5
- TSH2B
- TTRAP
- UBE2N
- UBE2V2
- UEV2
- UIMC1
- WHSC1
- XLF
- XRCC4
- XRCC5
- XRCC6
- polmu
|
|
Impaired BRCA2 binding to PALB2
|
|
|
- ATM
- BACH1
- BARD1
- BLM
- BRCA1
- BRCA2
- BRIP1
- C16orf75
- C9orf76
- CTIP
- DNA2
- DNA2L
- EXO1
- EXOI
- FACD
- FANCD1
- FANCJ
- FANCN
- HEX1
- HNGS1
- HTATIP
- KAT5
- KIAA0083
- MRE11
- MRE11A
- NBN
- NBS
- NBS1
- P95
- PALB2
- PIR51
- RAD50
- RAD51
- RAD51A
- RAD51AP1
- RAD51B
- RAD51C
- RAD51D
- RAD51L1
- RAD51L2
- RAD51L3
- RBBP8
- REC2
- RECA
- RECQ2
- RECQ3
- RECQL2
- RECQL3
- RMI1
- RMI2
- RNF53
- TIP60
- TOP3
- TOP3A
- WRN
- XRCC2
|
|
Defective DNA double strand break response due to BRCA1 loss of function
|
|
|
|
|
Defective DNA double strand break response due to BARD1 loss of function
|
|
|
|
|
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
|
|
|
- AP2TF
- C18orf5
- FOR
- KCTD1
- KCTD15
- SDR41C1
- SMT3C
- SMT3H3
- SUMO1
- TFAP2
- TFAP2A
- TFAP2B
- TFAP2BL1
- TFAP2C
- TFAP2D
- TFAP2E
- UBC9
- UBCE9
- UBE2I
- UBL1
- WOX1
- WWOX
|
|
Mtb iron assimilation by chelation
|
|
|
- GIG12
- LF
- LTF
- Rv2895c
- bfr
- bfrA
- bfrB
- ftn
- irtA
- irtB
|
|
Regulation of TNFR1 signaling
|
|
|
- API1
- API2
- API3
- BIRC2
- BIRC3
- BIRC4
- C20orf18
- CASP8
- CHIP
- CHUK
- CLIP3
- CLIPR59
- CYLD
- CYLD1
- DUBA7
- EBI6
- FADD
- FAM105B
- FIP2
- FIP3
- GLC1E
- GNB2L1
- HIP7
- HYPL
- IAP3
- IKBKB
- IKBKE
- IKBKG
- IKKA
- IKKB
- IKKE
- IKKI
- IMP3
- IMP4
- KIAA0151
- KIAA0722
- KIAA0757
- KIAA0849
- KIAA1532
- MAPKAPK2
- MCH5
- MIB2
- MIHB
- MIHC
- MORT1
- NAK
- NEMO
- NRP
- OPG199
- OPTN
- OTDC1
- OTUD1
- OTUD7B
- OTUD7C
- OTULIN
- PD1
- PSL1
- PSL2
- PUBC1
- RACK1
- RBCK1
- RIP
- RIP1
- RIPK1
- RNF31
- RNF48
- RNF49
- RNF54
- RPS27A
- SFT
- SHARPIN
- SIPL1
- SKD
- SPATA2
- SPI-2
- SPPL2A
- SPPL2B
- STUB1
- T6BP
- TAX1BP1
- TBK1
- TCF16
- TNF
- TNFA
- TNFAIP3
- TNFAR
- TNFR1
- TNFRSF1A
- TNFSF2
- TRADD
- TRAF1
- TRAF2
- TRAP3
- UBA52
- UBA80
- UBB
- UBC
- UBC4
- UBC5A
- UBC5B
- UBC5C
- UBCE7
- UBCE7IP3
- UBCEP1
- UBCEP2
- UBCH4
- UBCH5
- UBCH5A
- UBCH5B
- UBCH5C
- UBCH7
- UBE2D1
- UBE2D2
- UBE2D3
- UBE2L3
- UBP41
- UL36
- ULK1
- UNP
- UNPH
- USP2
- USP21
- USP23
- USP4
- XAP3
- XAP4
- XIAP
- ZA20D1
- ZIBRA
- ZZANK1
|
|
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
|
|
|
- API1
- API2
- APO3L
- BAFF
- BAFFR
- BIRC2
- BIRC3
- BLYS
- BR3
- CAP-1
- CD40L
- CD40LG
- CRAF1
- D12S370
- DR3LG
- FN14
- HVEML
- LIGHT
- LTA
- LTB
- LTBR
- MAP3K14
- MIHB
- MIHC
- NIK
- OPGL
- RANK
- RANKL
- RNF48
- RNF49
- TALL1
- TNFB
- TNFC
- TNFCR
- TNFR3
- TNFRSF11A
- TNFRSF12A
- TNFRSF13C
- TNFRSF3
- TNFSF1
- TNFSF11
- TNFSF12
- TNFSF13B
- TNFSF14
- TNFSF20
- TNFSF3
- TNFSF5
- TRAF2
- TRAF3
- TRAFAMN
- TRANCE
- TRAP
- TRAP3
- ZTNF4
|
|
Regulation of necroptotic cell death
|
|
|
- AIP1
- ALIX
- API1
- API2
- API3
- BIRC2
- BIRC3
- BIRC4
- CASP8
- CDC37
- CDC37A
- CHIP
- ESA1
- FADD
- FLOT1
- FLOT2
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- IAP3
- ITCH
- KIAA1375
- M17S1
- MCH5
- MDA9
- MIHB
- MIHC
- MLKL
- MORT1
- OGT
- PARK2
- PDCD6IP
- PELI1
- PRISM
- PRKN
- RIP
- RIP1
- RIP3
- RIPK1
- RIPK3
- RNF48
- RNF49
- RPS27A
- SDCBP
- STUB1
- SYCL
- TRADD
- TRAF2
- TRAP3
- UBA52
- UBA80
- UBB
- UBC
- UBCE7
- UBCEP1
- UBCEP2
- UBCH7
- UBE2L3
- XIAP
|
|
RIPK1-mediated regulated necrosis
|
|
|
- AIP1
- ALIX
- API1
- API2
- API3
- APO2
- APO2L
- APT1
- APT1LG1
- BIRC2
- BIRC3
- BIRC4
- CASP8
- CD95L
- CHIP
- DR4
- DR5
- ESA1
- FADD
- FAS
- FAS1
- FASL
- FASLG
- FLOT1
- FLOT2
- IAP3
- ICP6
- KIAA1375
- KILLER
- M17S1
- MCH5
- MDA9
- MIHB
- MIHC
- MLKL
- MORT1
- NS
- OGT
- PDCD6IP
- RIP
- RIP1
- RIP3
- RIPK1
- RIPK3
- RIR1
- RNF48
- RNF49
- SDCBP
- STUB1
- SYCL
- TNFRSF10A
- TNFRSF10B
- TNFRSF6
- TNFSF10
- TNFSF6
- TRADD
- TRAF2
- TRAIL
- TRAILR1
- TRAILR2
- TRAP3
- TRICK2
- XIAP
- ZTNFR9
|
|
TNFR1-induced proapoptotic signaling
|
|
|
- API1
- API2
- API3
- BIRC2
- BIRC3
- BIRC4
- C20orf18
- CASP8
- CYLD
- CYLD1
- DUBA7
- FADD
- FIP2
- GLC1E
- HIP7
- HYPL
- IAP3
- IKBKE
- IKKE
- IKKI
- KIAA0151
- KIAA0757
- KIAA0849
- MCH5
- MIB2
- MIHB
- MIHC
- MORT1
- NAK
- NRP
- OPTN
- OTDC1
- OTUD1
- OTUD7B
- OTUD7C
- PD1
- RBCK1
- RIP
- RIP1
- RIPK1
- RNF31
- RNF48
- RNF49
- RNF54
- SHARPIN
- SIPL1
- SKD
- SPATA2
- TBK1
- TNF
- TNFA
- TNFAIP3
- TNFAR
- TNFR1
- TNFRSF1A
- TNFSF2
- TRADD
- TRAF2
- TRAP3
- UBCE7IP3
- UBP41
- UL36
- UNP
- UNPH
- USP2
- USP21
- USP23
- USP4
- XAP3
- XAP4
- XIAP
- ZA20D1
- ZIBRA
- ZZANK1
|
|
TNFR1-induced NF-kappa-B signaling pathway
|
|
|
- API1
- API2
- API3
- BIRC2
- BIRC3
- BIRC4
- C20orf18
- CHUK
- CYLD
- CYLD1
- DUBA7
- EBI6
- FIP2
- FIP3
- GLC1E
- GNB2L1
- HIP7
- HYPL
- IAP3
- IKBKB
- IKBKG
- IKKA
- IKKB
- KIAA0733
- KIAA0757
- KIAA0849
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- MIHB
- MIHC
- NEMO
- NRP
- OPTN
- OTDC1
- OTUD1
- OTUD7B
- OTUD7C
- PD1
- RACK1
- RBCK1
- RIP
- RIP1
- RIPK1
- RNF31
- RNF48
- RNF49
- RNF54
- SHARPIN
- SIPL1
- SPATA2
- TAB1
- TAB2
- TAB3
- TAK1
- TCF16
- TNF
- TNFA
- TNFAIP3
- TNFAR
- TNFR1
- TNFRSF1A
- TNFSF2
- TRADD
- TRAF1
- TRAF2
- TRAP3
- UBCE7IP3
- UBP41
- UNP
- UNPH
- USP2
- USP21
- USP23
- USP4
- XAP3
- XAP4
- XIAP
- ZA20D1
- ZIBRA
|
|
IKK complex recruitment mediated by RIP1
|
|
|
- API1
- API2
- BIRC2
- BIRC3
- BLU
- CD14
- CHUK
- CROC1
- ESOP1
- FIP3
- IKBKB
- IKBKG
- IKKA
- IKKB
- LY96
- MD2
- MIHB
- MIHC
- NEMO
- PRVTIRB
- PUBC1
- RIP
- RIP1
- RIP3
- RIPK1
- RIPK3
- RNF48
- RNF49
- RNF85
- RPS27A
- SFT
- TCF16
- TICAM1
- TICAM2
- TIRAP3
- TIRP
- TLR4
- TRAF6
- TRAM
- TRIF
- UBA52
- UBA80
- UBB
- UBC
- UBC4
- UBC5A
- UBC5B
- UBC5C
- UBCEP1
- UBCEP2
- UBCH4
- UBCH5
- UBCH5A
- UBCH5B
- UBCH5C
- UBE2D1
- UBE2D2
- UBE2D3
- UBE2N
- UBE2V
- UBE2V1
- UEV1
|
|
TICAM1, RIP1-mediated IKK complex recruitment
|
|
|
- API1
- API2
- BIRC2
- BIRC3
- BLU
- CHUK
- CROC1
- FIP3
- IKBKB
- IKBKG
- IKKA
- IKKB
- MIHB
- MIHC
- NEMO
- PRVTIRB
- PUBC1
- RIP
- RIP1
- RIP3
- RIPK1
- RIPK3
- RNF48
- RNF49
- RNF85
- RPS27A
- SFT
- TCF16
- TICAM1
- TLR3
- TRAF6
- TRIF
- UBA52
- UBA80
- UBB
- UBC
- UBC4
- UBC5A
- UBC5B
- UBC5C
- UBCEP1
- UBCEP2
- UBCH4
- UBCH5
- UBCH5A
- UBCH5B
- UBCH5C
- UBE2D1
- UBE2D2
- UBE2D3
- UBE2N
- UBE2V
- UBE2V1
- UEV1
|
|
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
|
|
|
|
|
Sensory processing of sound by inner hair cells of the cochlea
|
|
|
- ACZ
- AIE75
- ATP2B1
- BSN
- C20orf145
- C6orf32
- C9orf75
- CABP1
- CABP2
- CACH3
- CACN4
- CACNA1D
- CACNA2D2
- CACNB2
- CACNL1A2
- CACNLB2
- CAPZA1
- CAPZA2
- CAPZB
- CASK
- CCHL1A2
- CDH23
- CIB2
- CLIC5
- CLN4
- CMYA3
- DAL1
- DFNB25
- DFNB31
- DFNB36
- DFNB59
- DIFF48
- DNAJC5
- EPB41L1
- EPB41L3
- EPS8
- EPS8L2
- EPS8R2
- ESPN
- ESPNL
- EZR
- FAM65B
- FER1L2
- FSCN2
- GRXCR1
- GRXCR2
- KCNMA
- KCNMA1
- KCNMB1
- KCNQ4
- KIAA0338
- KIAA0386
- KIAA0434
- KIAA0558
- KIAA0559
- KIAA0987
- KIAA1526
- KIAA1774
- KIAA1812
- KIP2
- LHFPL5
- LIN2
- LRRC52
- MSN
- MYH9
- MYO15
- MYO15A
- MYO1C
- MYO3A
- MYO3B
- MYO7A
- MYSB
- NEAS
- OTOF
- PCDH15
- PCLO
- PJVK
- PL48
- PLS1
- PMCA1
- PTK9
- PTK9L
- RAB3A
- RDX
- RIPOR2
- SANS
- SLC17A8
- SLO
- SNAP
- SNAP25
- SPTA2
- SPTAN1
- SPTB2
- SPTBN1
- STRC
- STX1
- STX1A
- SYB2
- SYN1
- SYP
- TMC1
- TMC2
- TMHS
- TMIE
- TPRN
- TWF1
- TWF2
- USH1B
- USH1C
- USH1F
- USH1G
- VAMP2
- VGLUT3
- VIL2
- WHRN
- XIRP2
- ZNF231
|
|
2-LTR circle formation
|
|
|
- BAF
- BANF1
- BCRG1
- DFS70
- G22P1
- G22P2
- HMGA1
- HMGIY
- LEDGF
- LIG4
- PSIP1
- PSIP2
- XRCC4
- XRCC5
- XRCC6
- gag
- gag-pol
- rev
- vif
- vpr
- vpu
|
|
Nuclear Envelope Breakdown
|
|
|
- BAF
- BANF1
- BCRG1
- EDMD
- EMD
- LEMD2
- LEMD3
- MAN1
- STA
- VRK1
|
|
Integration of provirus
|
|
|
- BAF
- BANF1
- BCRG1
- CYPA
- DFS70
- HMGA1
- HMGIY
- KPNA1
- LEDGF
- PPIA
- PSIP1
- PSIP2
- RCH2
- gag
- gag-pol
- rev
- vif
- vpr
- vpu
|
|
APOBEC3G mediated resistance to HIV-1 infection
|
|
|
- BAF
- BANF1
- BCRG1
- CYPA
- DFS70
- HMGA1
- HMGIY
- LEDGF
- PPIA
- PSIP1
- PSIP2
- gag
- gag-pol
- rev
- vif
- vpr
- vpu
|
|
Integration of viral DNA into host genomic DNA
|
|
|
- BAF
- BANF1
- BCRG1
- DFS70
- HMGA1
- HMGIY
- LEDGF
- PSIP1
- PSIP2
- gag
- gag-pol
- rev
- vif
- vpr
- vpu
|
|