GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding ▲	PubMed ID
Streptococcus pneumoniae	CTB-PsaA pentamers	GM1	Monosialoglycosphingolipids	Serum, Saliva, Nasal/bronchial wash samples	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	15358234
Sendai virus	Unknown	Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside)	Monosialoglycosphingolipids	Granulocytes	NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Binding	8823909
Influenza virus	Hemagglutinin (HA)	Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside)	Monosialoglycosphingolipids	Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas)	NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Binding	11030743
Actinomyces naeslundii	Unknown	GM1	Monosialoglycosphingolipids	Human brain	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	2358461
Escherichia coli	S-fimbriae	unnamed ligand	Oligosaccharides	Neural cell lines	NeuAc(a2-3)Gal(b1-3)GalNAc	Binding	16564136
Polyoma virus	Capsid protein VP1	Sialylated oligosaccharides	Oligosaccharides	Cell surface	NeuAc(a2-3)Gal(b1-3)GalNAc	Binding	8805524
Helicobacter pylori	Unknown	unnamed ligand	Oligosaccharides	Stomach	NeuAc(a2-3)Gal(b1-4)GlcNAc	Binding	16564136
Polyoma virus	Unknown	Sialylated oligosaccharides	Oligosaccharides	Erythrocytes	NeuAc(a2-3)Gal(b1-3)GalNAc	Binding	6316632
Escherichia coli	K99	unnamed ligand	Oligosaccharides	Intestinal cells	NeuAc(a2-3)Gal(b1-4)Glc	Binding	16564136
Influenza virus	Residues 226 (glutamine) and 228 (glycine)	Sialic acid linked to α2,3Galβ1,3GalNAc	Oligosaccharides	Avian/equine isolates	NeuAc(a2-3)Gal(b1-3)GalNAc	Binding	7975212