GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding ▲	PubMed ID
Polyoma virus	Unknown	unnamed ligand	Oligosaccharides	Murine small plaque	NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc	Binding	8574698
Reovirus	Unknown	Sialic acid (α2,6)	Saccharides	Most organs including the central nervous system/heart/liver	NeuAc(a2-6)	Binding	18216114
Bordetella pertussis	Adhesins	terminal Gal(3SO4) β1- residues	Sulfoglycosphingolipids	Human lung, Human trachea	Gal(3SO4)(b	Binding	1918002
Bordetella pertussis	FHA (filamentous hemagglutinin)	Sulfatide (CSE)	Sulfoglycosphingolipids	Cell surface	HSO3(-3)Gal(b1-1)Cer	Binding	10341176
Mycoplasma pneumoniae	Adhesins	Sulfatide (CSE)	Sulfoglycosphingolipids	Erythrocytes	HSO3(-3)Gal(b1-1)Cer	Binding	2470754
Helicobacter pylori	Adhesins	Sulfatide (CSE)	Sulfoglycosphingolipids	Human gastric mucosa	HSO3(-3)Gal(b1-1)Cer	Binding	2037054
Mycoplasma pneumoniae	Unknown	Sulfo-lactosylceramide (SM3)	Sulfoglycosphingolipids	Human colon adenocarcinoma cells (WiDr )	HSO3(-3)Gal(b1-4)Glc(b1-1)Cer	Binding	2470753
Human immunodeficiency virus	gp120	Sulfatide (CSE)	Sulfoglycosphingolipids	Human U373-MG glioma and SK-N-MC neuroblastoma cells, Human colon epithelial HT29 cells	HSO3(-3)Gal(b1-1)Cer	Binding	15973004
Helicobacter pylori	Neutrophil-activating proteins (150-kDa)	Sulfatide (CSE)	Sulfoglycosphingolipids	Human meconium	HSO3(-3)Gal(b1-1)Cer	Binding	9228091
Human immunodeficiency virus	Envelope glycoprotein gp120	Galactosyl sulfatide	Sulfoglycosphingolipids	Neural receptor	HSO3(-3)Gal(b1-1)Cer	Binding	1871126