GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **376 - 400** of **557** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Tie2 Signaling	Angiopoietin-1 receptor Angiopoietin-1 Angiopoietin-2 Angiopoietin-like protein 4 Docking protein 2 GTPase NRas Growth factor receptor bound protein 14 Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-4,5-bisphosphate 3-kinase small monomeric GTPase	A5D7R9 A7MBB8 B2Z4B2 E1BMX0 F1MBA2 F1MYM3 F1N339 F1N7C3 O18920 O77802 P23726 P23727 P32871 Q06807 Q0IIE2 Q1RMW5 Q3T0F9	ANG1 ANG2 ANGPT1 ANGPT2 ANGPT4 ANGPTL4 DOK2 GRB14 GRB2 GRB7 KRAS NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PTPN11 SHC1 SOS1 TEK TIE-2 TIE2	Bos taurus (cattle)
Regulation of RUNX3 expression and activity	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Core-binding factor subunit beta E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase E3 ubiquitin-protein ligase Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta Runt-related transcription factor Transforming growth factor beta-1 proprotein Tyrosine-protein kinase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein histone acetyltransferase	A0A3Q1LJ39 A0A3Q1MYL2 A0A3Q1N449 A0A452DI44 A7MBA2 E1B8D6 E1B9S8 E1BIM8 F1MBI1 F1MLS5 F1MLV1 F1MWE0 F1MXE4 F1MYE6 F1MYH8 F1N6Z0 G5E589 P0CG53 P0CH28 P33672 P56701 P62194 P62992 P63048 Q17QP9 Q2KI42 Q2KJ25 Q2KJ46 Q2KJE7 Q2YDE4 Q32KL2 Q3MHN0 Q3SX30 Q3SZ19 Q3SZC2 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3ZBD0 Q3ZBG0 Q3ZCK9 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0	CBFB EP300 MDM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSMF1 RPS27A RUNX3 SMURF1 SMURF2 SRC SUG1 TGFB1 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Bos taurus (cattle)
MAPK1 (ERK2) activation	Dual specificity mitogen-activated protein kinase kinase 2 Interleukin 6 cytokine family signal transducer Interleukin 6 receptor Interleukin-6 Mitogen-activated protein kinase 1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type	A0A3S5ZPX3 E1BCP6 E1BD36 E1BJQ3 F1MCX4 F1N0D6 F1N339 P26892 P46196	ERK2 IL6 IL6R IL6ST JAK1 JAK2 MAP2K2 MAPK1 PRKM1 PTPN11 TYK2	Bos taurus (cattle)
Metabolism of folate and pterines	10-formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate dehydrogenase 5-formyltetrahydrofolate cyclo-ligase C-1-tetrahydrofolate synthase, cytoplasmic Dihydrofolate reductase Folate receptor 2 (Fetal) Folylpolyglutamate synthase Methylenetetrahydrofolate reductase Monofunctional C1-tetrahydrofolate synthase, mitochondrial Proton-coupled folate transporter Reduced folate transporter Serine hydroxymethyltransferase, mitochondrial Serine hydroxymethyltransferase Solute carrier family 25 member 32 methenyltetrahydrofolate cyclohydrolase methenyltetrahydrofolate cyclohydrolase	A0A140T872 A0A140T896 A0A3Q1MU29 A0A3Q1NGK6 A0A452DI11 A4FUD0 E1BDG9 E1BMG9 E1BNJ2 F1MWN5 G3X7X2 Q05B81 Q0VCN9 Q0VCR7 Q1RMT3 Q3SZ20	ALDH1L1 ALDH1L2 DHFR FOLR2 FPGS HCP1 MTHFD1 MTHFD1L MTHFD2 MTHFD2L MTHFR MTHFS PCFT SHMT1 SHMT2 SLC19A1 SLC25A32 SLC46A1	Bos taurus (cattle)
ECM proteoglycans	Aggrecan core protein Agrin Biglycan Brevican core protein Cartilage oligomeric matrix protein Decorin Dentin matrix acidic phosphoprotein 1 Dentin sialophosphoprotein Hyaluronan and proteoglycan link protein 1 Integrin beta-6 Integrin beta Integrin beta Integrin beta Integrin subunit alpha 2 Integrin subunit alpha 2b Integrin subunit alpha 7 Integrin subunit alpha 9 Integrin subunit alpha V Matrilin 1 Matrilin 3 Matrilin 4 Neurocan Plasminogen activator inhibitor 1 SPARC Tenascin C Tenascin N Tenascin R Tenascin XB VWFA domain-containing protein Versican core protein Vitronectin	A0A140T8D2 A0A3Q1LTY7 A0A3Q1LZT3 A0A3Q1MXS2 A0A452DIJ9 E1BB79 E1BDF3 E1BGA0 E1BKN2 E1BMV3 F1MBA3 F1MD94 F1MGZ4 F1MJM1 F1MMH2 F1MPK6 F1MQ31 F1MRZ6 F1MTN1 F1N2Y8 F1N368 G3MZB1 P13213 P21793 P21809 P35445 P55252 P81282 Q3ZBS7 Q8SQB8 Q8SQB9	ACAN AGRN BCAN BGN COMP CRTL1 CSPG2 DCN DMP1 DSPP HAPLN1 ITGA2 ITGA2B ITGA7 ITGA9 ITGAV ITGAX ITGB1 ITGB3 ITGB5 ITGB6 MATN1 MATN3 MATN4 NCAN SERPINE1 SPARC TNC TNN TNR TNXB VCAN VTN	Bos taurus (cattle)
Interleukin-9 signaling	Cytokine receptor common subunit gamma Interleukin 9 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase	A0A140T878 A0A3Q1ME65 E1BEL4 E1BF10 F1MX38 F1N0D6 Q95115 Q95118	IL2RG IL9 JAK1 JAK3 MGF STAT1 STAT3 STAT5A STAT5B	Bos taurus (cattle)
Erythropoietin activates RAS	CRK like proto-onco, adaptor protein Erythropoietin receptor Erythropoietin Growth factor receptor-bound protein 2 Insulin receptor substrate 2 Proto-oncogene vav Rap guanine nucleotide exchange factor 1 SHC-transforming protein 1 Tyrosine-protein kinase Tyrosine-protein kinase	A0A3Q1LXN8 E1BCP6 F1MEQ7 F1MJE0 F1N261 G3N016 P48617 Q08DN7 Q0IIE2 Q3T0F9	CRKL EPO EPOR GRB2 IRS2 JAK2 LYN RAPGEF1 SHC1 VAV1	Bos taurus (cattle)
FRS-mediated FGFR1 signaling	FRS3 protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase NRas Growth factor receptor-bound protein 2 Klotho SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type small monomeric GTPase	A0A3Q1LUE0 A0A3Q1NAV6 A0MTF4 A5D7R9 A6H792 D8KXU9 E1B7I9 E1BAI2 E1BGY3 E1BHC1 E1BJU2 E1BMX0 E1BP37 F1N339 F1N6G8 F1N7C3 G3MXR4 G3XGD3 P03968 P03969 Q3T0F9	AFGF FGF1 FGF10 FGF17 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF5 FGF5C FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 FRS2 FRS3 Fgf4 GRB2 HBGF-1 KL KRAS NRAS PTPN11 SOS1	Bos taurus (cattle)
Serine biosynthesis	D-3-phosphoglycerate dehydrogenase Phosphoserine aminotransferase Phosphoserine phosphatase Serine incorporator 1 Serine incorporator 2 Serine incorporator 3 Serine incorporator 4 Serine incorporator 5 Serine racemase	A0A140T866 A0A3Q1LF32 A0A3S5ZPF7 A0JNI4 A4FUZ5 F1MGF0 Q2KHU0 Q3MHV9 Q58CW5	PHGDH PSAT1 PSPH SERINC1 SERINC2 SERINC3 SERINC4 SERINC5 SRR TDE2 TDE2L	Bos taurus (cattle)
Vasopressin-like receptors	Arginine vasopressin Oxytocin receptor Oxytocin-neurophysin 1 Vasopressin V1a receptor Vasopressin V1b receptor Vasopressin V2 receptor	A0A3Q1LXY0 F1ME85 F6PV87 P01175 P48044 P56449	AVP AVPR1A AVPR1B AVPR2 OXT OXTR	Bos taurus (cattle)
PD-1 signaling	BOLA-DQA1 protein BoLA-DR-alpha Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein MHC class II antigen MHC class II antigen Major histocompatibility complex, class II, DQ alpha 5 Major histocompatibility complex, class II, DY alpha Programmed cell death 1 ligand 2 Programmed cell death-ligand 1 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 TRAV29-1*01 Tyrosine-protein kinase CSK Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Tyrosine-protein phosphatase non-receptor type	A0A3Q1M088 A0A3Q1M2W6 A0A3Q1M3D2 A0A3Q1M739 A0A3Q1MT21 A6H6Y1 A6QQE7 C5NU11 E1BLZ1 F1MJK4 F1MJU5 F1ML60 F1N0X9 F1N339 G3MWT2 G8JL01 Q0VBZ0 Q0VCU4 Q28072 Q28073 Q30309 Q3ZCM0 Q70IB5	BLA-DQB BOLA-DQA1 BOLA-DQA2 BOLA-DQA5 BOLA-DRA BOLA-DRB2 BOLA-DRB3 BOLA-DYA BOLA-DYB BoLA-DIB BoLA-DRA BoLA-DYB CD247 CD274 CD3D CD3E CD3G CD4 CSK DYB HLA-DRA LCK LOC100848815 PD-L1 PDCD1LG2 PTPN11 PTPN6 TRAV29-1	Bos taurus (cattle)
FRS-mediated FGFR2 signaling	FRS3 protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase NRas Growth factor receptor-bound protein 2 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type small monomeric GTPase	A0A3Q1LRU7 A0A3Q1M3Q3 A0A3Q1NAV6 A0MTF4 A5D7R9 A6H792 D8KXU9 E1B7I9 E1BGY3 E1BHC1 E1BJU2 E1BMX0 E1BP37 F1MHC6 F1N339 F1N6G8 F1N7C3 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969 Q3T0F9	AFGF FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF9 FGFA FGFR2 FRS2 FRS3 Fgf4 GRB2 HBGF-1 KRAS NRAS PTPN11 SOS1	Bos taurus (cattle)
Clathrin-mediated endocytosis	ADP ribosylation factor GTPase activating protein 1 AP-1 complex subunit beta-1 AP-2 complex subunit alpha-2 AP-2 complex subunit alpha AP-2 complex subunit mu AP-2 complex subunit sigma AP2 associated kinase 1 Actin nucleation-promoting factor WASL Actin-related protein 2/3 complex subunit 1A Actin-related protein 2/3 complex subunit 2 Actin-related protein 2/3 complex subunit 3 Actin-related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2 Actin-related protein 3 Adaptin ear-binding coat-associated protein 1 Amphiphysin Amphiregulin Apolipoprotein B Arginine vasopressin Beta-2 adrenergic receptor Beta-arrestin-1 Beta-arrestin-2 Betacellulin Bridging integrator 1 Cation-dependent mannose-6-phosphate receptor Clathrin heavy chain 1 Clathrin light chain A Clathrin light chain B Cyclin G associated kinase Cystic fibrosis transmembrane conductance regulator DAB adaptor protein 2 Dishevelled segment polarity protein 2 DnaJ heat shock protein family (Hsp40) member C6 Dynamin-1 E3 ubiquitin-protein ligase CBL EPS15 protein Endophilin-A2 Epidermal growth factor receptor pathway substrate 15 like 1 Epiregulin Epithelial mitogen Epsin 1 Epsin 2 FCH and mu domain containing endocytic adaptor 1 FCH and mu domain containing endocytic adaptor 2 Formin binding protein 1 Formin-binding protein 1-like GTPase-activating protein and VPS9 domain-containing protein 1 Growth factor receptor-bound protein 2 Heat shock cognate 71 kDa protein Hepatocyte growth factor-regulated tyrosine kinase substrate Huntingtin interacting protein 1 related Huntingtin interacting protein 1 Insulin like growth factor 2 receptor Interleukin-7 receptor subunit alpha Intersectin 1 Intersectin 2 KIAA0319 LDL receptor related protein 2 LDLRAP1 protein Low-density lipoprotein receptor Muscarinic acetylcholine receptor M2 NECAP endocytosis associated 2 Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Polyubiquitin-B Polyubiquitin-C Proheparin-binding EGF-like growth factor Protein Wnt Protein kinase C and casein kinase substrate in neurons 2 Protein kinase C and casein kinase substrate in neurons 3 Protein kinase C and casein kinase substrate in neurons protein 1 RALBP1 associated Eps domain containing 1 Ras-related protein Rab-5A Receptor protein-tyrosine kinase SH3 domain containing GRB2 like 2, endophilin A1 SH3 domain containing GRB2 like 3, endophilin A3 SH3 domain containing kinase binding protein 1 Scavenger receptor class B member 2 Serotransferrin Signal transducing adaptor molecule 2 Signal transducing adaptor molecule Solute carrier family 18 member A3 Solute carrier family 2 member 8 Sorting nexin Sorting nexin Stonin-1 Stonin-2 Substance-P receptor Synaptosome associated protein 91 Synaptotagmin 11 Synaptotagmin 8 Synaptotagmin 9 Synaptotagmin-1 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Thyroid hormone receptor interactor 10 Trans-golgi network protein 2 Transferrin receptor protein 1 Transforming growth factor alpha Type-1 angiotensin II receptor Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Vasopressin V2 receptor Vesicle-associated membrane protein 2 Vesicle-associated membrane protein 4 Vesicle-associated membrane protein 8 dynamin GTPase phosphoinositide 5-phosphatase phosphoinositide 5-phosphatase small monomeric GTPase	A0A3Q1LK58 A0A3Q1LN00 A0A3Q1LPM3 A0A3Q1LVF9 A0A3Q1LXE7 A0A3Q1LXY0 A0A3Q1M7J4 A0A3Q1M808 A0A3Q1M839 A0A3Q1MAH6 A0A3Q1MBL1 A0A3Q1MG95 A0A3Q1MHB0 A0A3Q1MIC9 A0A3Q1MKW3 A0A3Q1ML18 A0A3Q1MMI6 A0A3Q1MSK9 A0A3Q1MSZ4 A0A3Q1MWJ5 A0A3Q1NNG9 A0A3S5ZPN6 A2VDU0 A2VE27 A4IFN6 A4IFV0 A5D794 A5D7I1 A7MB62 A7MBI0 E1BBE2 E1BDG5 E1BDM2 E1BDP2 E1BE68 E1BIG6 E1BIN8 E1BJ14 E1BK36 E1BK71 E1BKY4 E1BNR0 E1BPM3 F1MBY5 F1MC50 F1MEV4 F1MGT4 F1MI54 F1MIB2 F1MIE6 F1MIX5 F1MJK4 F1MN01 F1MNI4 F1MRS2 F1MSM9 F1MUI0 F1MWF0 F1MX23 F1MZ25 F1MZY9 F1N1U1 F1N371 F1N4I2 F1N579 F1N6H1 F1N6W6 F6Q4T4 F6RJ01 F6RS49 G3MXC8 G3X6N3 G3X811 G8JL01 P01131 P04973 P04975 P0CG53 P0CH28 P11456 P17870 P19120 P25104 P41985 P48018 P48044 P49951 P61157 P62992 P63026 P63048 Q08DF4 Q08DS7 Q08DX1 Q0IIG7 Q0V8S0 Q0VCK5 Q148J6 Q17QC5 Q1JP79 Q1RMR9 Q28044 Q28072 Q2KJA1 Q32L97 Q3MHR7 Q3T035 Q3T093 Q3T0F9 Q3T0Y8 Q3ZC13 Q95107	AAK1 ACTR2 ACTR3 ADRB2 AGTR1 AMPH AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOB AREG ARFGAP1 ARP2 ARP3 ARPC1A ARPC2 ARPC3 ARPC4 ARPC5 ARRB1 ARRB2 AVP AVPR2 BIN1 BTC CBL CD3D CD3G CD4 CFTR CHRM2 CLTA CLTB CLTC CLTLB DAB2 DNAJC6 DNM1 DNM3 DVL2 EGFR EPGN EPN1 EPN2 EPS15 EPS15L1 EREG FCHO1 FCHO2 FNBP1 FNBP1L GAK GAPVD1 GRB2 HBEGF HGS HIP1 HIP1R HSC70 HSPA8 IGF2R IL7R ITSN1 ITSN2 KIAA0319 LDLR LDLRAP1 LRP2 M6PR NECAP1 NECAP2 OCRL PACSIN1 PACSIN2 PACSIN3 PIK3C2A PIP5K1C RAB5A RAB5B REPS1 RPS27A SCARB2 SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SLC18A3 SLC2A8 SNAP91 SNX18 SNX9 STAM STAM2 STON1 STON2 SYB2 SYNJ2 SYT1 SYT11 SYT8 SYT9 TACR1 TF TFRC TGFA TRIP10 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VAMP2 VAMP4 VAMP8 WASL WNT5A	Bos taurus (cattle)
Downstream signal transduction	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Adapter molecule crk BCAR1 scaffold protein, Cas family member CRK like proto-onco, adaptor protein Cytoplasmic protein Cytoplasmic protein GTPase NRas Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B RAS p21 protein activator 1 Rap guanine nucleotide exchange factor 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-4,5-bisphosphate 3-kinase small monomeric GTPase	A0A140T878 A0A3Q1LXN8 A0A3Q1ME65 A0A3Q1ME99 A0A3Q1MQ07 A0A3Q1N3Z8 A5D7R9 A6H720 B1H0W5 E1BIM8 E1BMX0 E1BQ32 F1MGJ4 F1MX38 F1MYF9 F1MYM3 F1N339 F1N7C3 F1N7N8 G3N016 P23726 P23727 P32871 Q1LZB2 Q1RMW5 Q2KJ15 Q3T0F9 Q95115	BCAR1 CRK CRKL GRB2 GRB7 KRAS MGF NCK1 NCK2 NRAS PDGFA PDGFB PDGFRA PDGFRB PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PTPN11 RAPGEF1 RASA1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B STAT6	Bos taurus (cattle)
Adherens junctions interactions	ANG2 protein Afadin, adherens junction formation factor CDH17 protein Cadherin 10 Cadherin 11 Cadherin 12 Cadherin 13 Cadherin 15 Cadherin 24 Cadherin 3 Cadherin 7 Cadherin 8 Cadherin-18 Cadherin-1 Cadherin-2 Cadherin-4 Cadherin-5 Cadherin-6 Catenin alpha 1 Catenin beta-1 Catenin delta 1 Cell adhesion molecule 1 Cell adhesion molecule 2 Cell adhesion molecule 3 Junction plakoglobin Nectin cell adhesion molecule 1 Nectin cell adhesion molecule 2 Nectin cell adhesion molecule 3 Poliovirus receptor-related 4 Ribonuclease A-domain domain-containing protein	A0A3Q1LN46 A0A3Q1M7P7 A0A3Q1M9M0 A0A3Q1MB78 A0A3Q1MHI4 A0A3Q1MRJ9 A0A3Q1MSS6 A0A5H1ZRH6 A2VDQ6 A6H6X2 A6H7H6 A6QLR1 E1BF53 E1BGT1 E1BIA5 E1BQ10 E1BQ11 F1MEW6 F1MQJ3 F1MSQ0 F1MUF6 F1MW29 F1N7M2 G3MZL1 G3MZM2 Q08DJ5 Q0VCX4 Q2TBL2 Q3SWX5 Q8SPJ1	AFDN ANG2 CADM1 CADM2 CADM3 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH17 CDH18 CDH2 CDH24 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CTNNA1 CTNNB1 CTNND1 JUP NECTIN1 NECTIN2 NECTIN3 NECTIN4 PVRL4 RAA2	Bos taurus (cattle)
RAC3 GTPase cycle	Abl interactor 1 Abl interactor 2 Actin-binding protein WASF1 Actin-binding protein WASF2 Active breakpoint cluster region-related protein Adhesion molecule with Ig like domain 2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 BAR/IMD domain containing adaptor protein 2 like 1 BAR/IMD domain-containing adapter protein 2 BCR activator of RhoGEF and GTPase C22H3ORF10 protein Caveolin-1 Cdc42 effector protein 1 Cell division control protein 42 homolog Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein DEP domain containing 1B Dedicator of cytokinesis 10 Delta(14)-sterol reductase LBR Delta-like protein Desmoglein 2 Diaphanous related formin 3 EMD protein Endoplasmic reticulum protein 27 FERM domain containing kindlin 2 Family with sequence similarity 62 (C2 domain containing), member A GIT ArfGAP 1 GIT ArfGAP 2 Granule associated Rac and RHOG effector 1 HSPC321 protein Integrin beta Lectin, mannose binding 1 MAGUK p55 subfamily member 7 MCF.2 cell line derived transforming sequence Melanoma cell adhesion molecule NADPH oxidase 1 NADPH oxidase 3 NADPH oxidase organizer 1 NCK associated protein 1 like NHS actin remodeling regulator Neutral amino acid transporter B(0) Neutrophil cytosolic factor 1 Neutrophil cytosolic factor 2 Neutrophil cytosolic factor 4 Oligophrenin-1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Progesterone receptor membrane component 2 RAC3 protein RNA binding motif protein 39 Rac GTPase activating protein 1 Ragulator complex protein LAMTOR1 Rap guanine nucleotide exchange factor 1 Rho GTPase activating protein 17 Rho GTPase activating protein 1 Rho GTPase activating protein 32 Rho GTPase activating protein 39 Rho GTPase activating protein 42 Rho GTPase activating protein 5 Rho GTPase activating protein 6 Rho GTPase-activating protein 15 Rho GTPase-activating protein 26 Rho GTPase-activating protein 35 SLIT and NTRK like family member 3 SLIT and NTRK like family member 5 SLIT-ROBO Rho GTPase activating protein 2 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase TAO3 Starch binding domain 1 Synapse defective Rho GTPase homolog 1 Synaptobrevin homolog YKT6 Synaptosomal-associated protein Transferrin receptor protein 1 Tyrosine-protein kinase Vang-like protein Vav guanine nucleotide exchange factor 2 non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase p21 protein (Cdc42/Rac)-activated kinase 4 phosphoinositide 5-phosphatase receptor protein-tyrosine kinase	A0A140T8D2 A0A3Q1LLI7 A0A3Q1LMM5 A0A3Q1LNB6 A0A3Q1LPH8 A0A3Q1LWV5 A0A3Q1LWZ4 A0A3Q1LXN8 A0A3Q1M0G8 A0A3Q1M4M7 A0A3Q1M7Q3 A0A3Q1MKI4 A0A3Q1MP86 A0A3Q1MQK6 A0A3Q1MQP9 A0A3Q1MRV3 A0A3Q1MSA1 A0A3Q1MT43 A0A3Q1MTW8 A0A3Q1N078 A0A3Q1N6J8 A0A452DHY1 A0A452DIS6 A0JN43 A2VDK6 A4IF90 A5PK69 A6H709 A6QNS3 A6QQV8 A6QQZ7 A7MB21 A8YXX8 E1B7C4 E1B801 E1B876 E1B8X9 E1BAA4 E1BAJ4 E1BBA0 E1BDN7 E1BFF3 E1BGL2 E1BHQ9 E1BI41 E1BIG6 E1BJ31 E1BJP2 E1BLB3 E1BM23 E1BMN2 E1BN47 E1BNR7 E1BPJ7 F1MBY5 F1MFC2 F1MLS2 F1MTN6 F1MWH1 F1MWH8 F1MXR0 F1MXU4 F1N1Q7 F1N348 F1N513 F1N6V1 F1N7Q8 F6QJJ8 F6RWK1 O46521 O46522 P23726 P23727 P79132 Q08E52 Q0IIJ3 Q17QW1 Q17QZ0 Q2KJ93 Q2T9M8 Q3SX08 Q3T000 Q3T0D8 Q5EAD0 Q95JC7	ABI1 ABI2 ABL2 ABR AMIGO2 ARAP2 ARAP3 ARHGAP1 ARHGAP15 ARHGAP17 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP42 ARHGAP5 ARHGAP6 ASCT2 BAIAP2 BAIAP2L1 BCR BORG5 BRK1 C22H3ORF10 CAV1 CDC42 CDC42EP1 CYBA CYBB CYFIP1 DEPDC1B DIAPH3 DOCK10 DSG2 EMD EPHA2 ERP27 ESYT1 FAM62A FERMT2 GARRE1 GIT1 GIT2 HSPC321 ITGB1 JAG1 LAMTOR1 LBR LMAN1 MCAM MPP7 NCF1 NCF2 NCF4 NCKAP1L NHS NOX1 NOX3 NOXO1 OCRL OPHN1 PAK1 PAK2 PAK4 PGRMC2 PIK3R1 PIK3R2 PREX1 RAC3 RACGAP1 RAPGEF1 RBM39 SLC1A5 SLITRK3 SLITRK5 SNAP23 SRGAP2 STBD1 SWAP70 SYDE1 TAOK3 TFRC TRIO VANGL1 VAV2 VRK2 WASF1 WASF2 YKT6	Bos taurus (cattle)
Extracellular matrix organization	Fibronectin	G5E5A9	FN1	Bos taurus (cattle)
AUF1 (hnRNP D0) binds and destabilizes mRNA	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Eukaryotic translation initiation factor 4 gamma 1 Heat shock 70 kDa protein 1A Heat shock cognate 71 kDa protein Heat shock protein beta-1 Heteroous nuclear ribonucleoprotein D Polyadenylate-binding protein 1 Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A3Q1M8I4 A0A452DI44 A0A452DIY4 A7MBA2 E1BD83 F1MBI1 F1MLV1 F1MWE0 F1MX04 F1MXE4 F1MYH8 F1N6Z0 G5E589 P0CG53 P0CH28 P19120 P33672 P56701 P61286 P62194 P62992 P63048 Q17QP9 Q27975 Q2KI42 Q2KJ25 Q2KJ46 Q2KJE7 Q2YDE4 Q32KL2 Q3MHN0 Q3SX30 Q3SZ19 Q3SZC2 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3T149 Q3ZBD0 Q3ZBG0 Q3ZCK9 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0	EIF4G1 HNRNPD HSC70 HSP27 HSP70-1 HSPA1A HSPA8 HSPB1 PABP1 PABPC1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A SUG1 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Bos taurus (cattle)
Signaling by Activin	Activin receptor type-2A Inhibin alpha chain Inhibin beta A chain Inhibin beta B chain Mitogen-activated protein kinase 1 Mitogen-activated protein kinase Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Serine/threonine-protein kinase receptor Transforming growth factor beta receptor 3 receptor protein serine/threonine kinase receptor protein serine/threonine kinase	A0A3Q1LMU4 A0A3Q1MGJ6 B0JYL0 E1B8P9 E1B9H5 E1BE92 F1MMW7 F1MSQ2 F1MUZ3 P07994 P07995 P46196 Q28043	ACTRII ACVR1B ACVR1C ACVR2 ACVR2A ACVR2B ERK2 INHA INHBA INHBB MAPK1 MAPK3 PRKM1 SMAD2 SMAD3 SMAD4 TGFBR3	Bos taurus (cattle)
O-linked glycosylation of mucins	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 Beta-1,4-galactosyltransferase Beta-1,4-galactosyltransferase C1GALT1-specific chaperone 1 Glucosaminyl (N-acetyl) transferase 1 Glucosaminyl (N-acetyl) transferase 4 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Hexosyltransferase Hexosyltransferase Hexosyltransferase Hexosyltransferase Hexosyltransferase Mucin 15, cell surface associated Mucin 20, cell surface associated Mucin-1 Mucin-2 Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase like 5 Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase Sulfotransferase UDP-GlcNAc UDP-GlcNAc VWFD domain-containing protein	A0A3Q1LM69 A0A3Q1M2T0 A0A3Q1M633 A0A3Q1M6U9 A0A3Q1M986 A0A3Q1MN70 A0A3Q1MPZ8 A0A3Q1MQ00 A0A3Q1MUB2 A0A3Q1NK42 A0A3S5ZPG9 A6H6Z5 A6QLD9 A6QLX6 A7YY64 E1B9U7 E1BBP1 E1BCQ2 E1BDW8 E1BHN6 E1BKQ9 E1BPR6 F1MGN7 F1MSS4 F1MUJ7 F1MUW5 F6QA59 F6RJ62 G3N0Q1 G5E5A7 Q07537 Q08DM9 Q0VC83 Q0VC84 Q17QZ8 Q1LZD4 Q3SX46 Q7YQE1	B3GNT2 B3GNT4 B3GNT5 B3GNT6 B3GNT8 B3GNT9 B3GNTL1 B4GALT5 B4GALT6 C1GALT1 C1GALT1C1 CHST4 GALNT1 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT15 GALNT16 GALNT17 GALNT18 GALNT2 GALNT3 GALNT5 GALNT6 GALNT7 GALNT8 GALNTL1 GALNTL5 GCNT1 GCNT3 GCNT4 LOC789503 MUC1 MUC15 MUC2 MUC20	Bos taurus (cattle)
Removal of aminoterminal propeptides from gamma-carboxylated proteins	Coagulation factor IX Coagulation factor VII Coagulation factor X Growth arrest specific 6 Osteocalcin Prothrombin Vitamin K-dependent protein C Vitamin K-dependent protein S furin	A0A3Q1M616 A0A452DI66 A0A452DIP8 A1A4R0 B0JYR0 F1MBC5 F1MZ40 P07224 P22457	BGLAP F10 F2 F7 F9 FURIN GAS6 PROC PROS PROS1	Bos taurus (cattle)
RHOQ GTPase cycle	ADP ribosylation factor like GTPase 13B Actin nucleation-promoting factor WASL Anion exchange protein CDC42 effector protein (Rho GTPase binding) 3 CDC42 effector protein (Rho GTPase binding) 4 CPNE8 protein Caveolin-1 Cdc42 effector protein 1 Cdc42 effector protein 2 Cell division control protein 42 homolog Cystic fibrosis transmembrane conductance regulator DEP domain containing 1B Diaphanous related formin 3 E3 ubiquitin-protein ligase Formin binding protein 1 GIT ArfGAP 1 GIT ArfGAP 2 Gap junction alpha-1 protein Golgi associated PDZ and coiled-coil motif containing IQ motif containing GTPase activating protein 1 IQGAP3 protein Intersectin 1 Junction plakoglobin MAGUK p55 subfamily member 7 Neutral amino acid transporter B(0) Oligophrenin-1 Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Pleckstrin homology and RhoGEF domain containing G3 Ragulator complex protein LAMTOR1 Ras homolog family member Q Rho GTPase activating protein 17 Rho GTPase activating protein 1 Rho GTPase activating protein 32 Rho GTPase activating protein 33 Rho GTPase activating protein 5 Rho GTPase-activating protein 26 Rho GTPase-activating protein 35 Rho GTPase-activating protein 7 Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor 9 SLIT-ROBO Rho GTPase activating protein 2 STEAP3 metalloreductase STOM protein Scribble planar cell polarity protein Serine/threonine-protein kinase PAK 1 Synapse defective Rho GTPase homolog 1 Synaptosomal-associated protein Thyroid hormone receptor interactor 10 Transferrin receptor protein 1 Vang-like protein non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase p21 protein (Cdc42/Rac)-activated kinase 4	A0A3Q1LLI7 A0A3Q1LMM5 A0A3Q1LPM3 A0A3Q1LPT9 A0A3Q1LUY1 A0A3Q1LWV5 A0A3Q1LX25 A0A3Q1M0G8 A0A3Q1M7Q3 A0A3Q1MA22 A0A3Q1MPX4 A0A3Q1MXC6 A0A3Q1N6J8 A2VDU0 A5D784 A6H7H0 A6QQZ7 A8E4P3 E1B801 E1BAX1 E1BI41 E1BIG6 E1BKY4 E1BLB3 E1BM23 E1BMN2 E1BNR7 E1BP72 F1MBM9 F1MC48 F1MIZ6 F1MK42 F1MN01 F1MNI8 F1MS60 F1MXU4 F1N1Q7 F1N7Q8 F6RWK1 G3MWI1 P18246 P79132 Q08DN6 Q08E52 Q17QW1 Q17QZ0 Q2KI46 Q2KJ93 Q2T9M8 Q3T0D8 Q8SPJ1 Q95107 Q95JC7	ARHGAP1 ARHGAP17 ARHGAP26 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP5 ARHGEF7 ARHGEF9 ARL13B ASCT2 BORG1 BORG5 CAV1 CDC42 CDC42BPB CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CEP2 CFTR CPNE8 DEPDC1B DIAPH3 DLC1 FNBP1 GIT1 GIT2 GJA1 GOPC IQGAP1 IQGAP3 ITSN1 JUP LAMTOR1 MPP7 OPHN1 PAK1 PAK2 PAK4 PLEKHG3 PREX1 RHOQ SCRIB SLC1A5 SLC4A7 SNAP23 SRGAP2 STEAP3 STOM SYDE1 TFRC TRIP10 VANGL1 WASL WWP2	Bos taurus (cattle)
CD209 (DC-SIGN) signaling	NF-kappaB transcription factor p65 subunit Nuclear factor NF-kappa-B p105 subunit RELB proto-onco, NF-kB subunit Ribosomal protein S6 kinase cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase histone acetyltransferase histone acetyltransferase	A0A452DJE2 A1XG22 E1B8D6 E1BN61 F1MBB0 F1MD32 F1MKW9 P00517	CREBBP EP300 NFKB1 PRKACA PRKACB RELA RELB RPS6KA5	Bos taurus (cattle)
APC/C:Cdc20 mediated degradation of mitotic proteins	Anaphase promoting complex subunit 1 Anaphase promoting complex subunit 7 Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit CDC26 BUB1 mitotic checkpoint serine/threonine kinase B Cell division cycle 16 Cell division cycle 20 Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog E2 ubiquitin-conjugating enzyme Mitotic arrest deficient 2 like 1 Mitotic checkpoint protein BUB3 Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 S	A0A3Q1M862 A0A3Q1MAR8 A1A4R8 A7Z061 E1B945 E1BAB6 E1BK11 E1BM34 E1BPM5 F1MRW5 F1MWP1 F2Z4G9 G3MX31 G3N1P6 Q1JQB2 Q1RML1 Q2TA10 Q32PA5 Q3SZ31 Q3SZT7 Q3ZCF6 Q58DR0	ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ANAPC8 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC27 MAD2L1 UBCH10 UBE2C UBE2D1 UBE2E1 UBE2S	Bos taurus (cattle)
DAG and IP3 signaling	Protein kinase C delta type	A0A3Q1MRR6	PRKCD	Bos taurus (cattle)

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