GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **426 - 450** of **557** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Acrosome Reaction and Sperm:Oocyte Membrane Binding	Acrosin CD9 antigen IZUMO family member 2 IZUMO family member 4 Izumo sperm-egg fusion protein 3 Izumo sperm-oocyte fusion 1	A6QL94 E1BC82 E1BDA8 F1MYA6 G5E5C6 P30932	ACR CD9 IZUMO1 IZUMO2 IZUMO3 IZUMO4	Bos taurus (cattle)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen-activated protein kinase kinase kinase 1 TNF receptor-associated factor 6	E1B847 Q3SX05 Q3ZCC3	ECSIT MAP3K1 TRAF6	Bos taurus (cattle)
Signaling by CSF3 (G-CSF)	Colony stimulating factor 3 receptor GRB2 associated binding protein 2 Granulocyte colony-stimulating factor Growth factor receptor-bound protein 2 SHC-transforming protein 1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type small monomeric GTPase	A0A3Q1M864 A0A3Q1MHG9 A0A3Q1MYA3 E1B9W2 E1BCP6 E1BMX0 F1MCX4 F1N0D6 F1N261 F1N339 P35833 Q0IIE2 Q3T0F9	CSF3 CSF3R GAB2 GCSF GRB2 JAK1 JAK2 KRAS LYN PTPN11 SHC1 SRC SYK TYK2	Bos taurus (cattle)
HDL clearance	Apolipoprotein A-I Cubilin High density lipoprotein binding protein Protein amnionless Scavenger receptor class B member 1	A0A3Q1MUD4 F1MKV7 F1MQD9 O18824 P15497	AMN APOA1 CUBN HDLBP SCARB1	Bos taurus (cattle)
Fructose biosynthesis	Aldo-keto reductase family 1 member B1 Sorbitol dehydrogenase	A0A493UA87 Q58D31	AKR1B1 SORD	Bos taurus (cattle)	G58161NS
Degradation of AXIN	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Axin 2 Axin-1 E3 ubiquitin-protein ligase RNF146-B E3 ubiquitin-protein ligase Poly [ADP-ribose] polymerase Poly [ADP-ribose] polymerase Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A3Q1LJ39 A0A3Q1M230 A0A452DI44 A0A452DIY4 A7MBA2 E1B8R5 E1BD83 F1MBI1 F1MLV1 F1MWE0 F1MXE4 F1MYH8 F1N6Z0 G3X7P3 G5E589 M5FK80 P0CG53 P0CH28 P33672 P56701 P62194 P62992 P63048 Q17QP9 Q2KI42 Q2KJ25 Q2KJ46 Q2KJE7 Q2YDE4 Q32KL2 Q3MHN0 Q3SX30 Q3SZ19 Q3SZC2 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3T139 Q3ZBD0 Q3ZBG0 Q3ZCK9 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0	AXIN1 AXIN2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RNF146B RPS27A SMURF2 SUG1 TNKS TNKS2 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Bos taurus (cattle)
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Cathepsin K Procathepsin L Serpin family B member 13	E1BIP8 P25975 Q5E968	CTSK CTSL CTSL1 SERPINB13	Bos taurus (cattle)
Glycolysis	ADP-dependent glucokinase ATP-dependent 6-phosphofructokinase, liver type ATP-dependent 6-phosphofructokinase, muscle type ATP-dependent 6-phosphofructokinase Beta-enolase Enolase 4 Fructose-bisphosphate aldolase Fructose-bisphosphate aldolase Fructose-bisphosphate aldolase Glucosamine-6-phosphate isomerase 1 Glucosamine-6-phosphate isomerase Glucose-6-phosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase, testis-specific Glyceraldehyde-3-phosphate dehydrogenase Hexokinase-1 Hexokinase-2 PGM2L1 protein Phosphoglycerate kinase 1 Phosphoglycerate mutase 1 Phosphoglycerate mutase Phosphoglycerate mutase Phosphotransferase Pyruvate kinase Pyruvate kinase Triosephosphate isomerase hexokinase hexokinase phosphopyruvate hydratase	A0A3Q1LMG1 A0A3Q1LR63 A0A3Q1M0F0 A0A3S5ZPB0 A0A452DIC9 A0A452DIX3 A1A4J1 A2VE47 A4FV08 A5D984 A5PKH8 A6QR19 A6QR34 E1BCW3 E1BME6 F1MIM3 F1MX69 F1N2F2 F6RG16 G3MXL6 P10096 Q0IIG5 Q1JPG7 Q2KJE5 Q3SZ62 Q3T0P6 Q3ZBD7 Q3ZC09	ADPGK ALDOA ALDOB ALDOC BPGM ENO2 ENO3 ENO4 GAPD GAPDH GAPDHS GCK GNPDA1 GNPDA2 GPI HK1 HK2 HK3 HKDC1 PFKL PFKM PFKP PGAM1 PGAM2 PGK1 PGM2L1 PKLR PKM PKM2 TPI1	Bos taurus (cattle)	G58161NS
Negative regulation of the PI3K/AKT network	Phosphatase and tensin homolog	F1MDX9	PTEN	Bos taurus (cattle)
Assembly of the pre-replicative complex	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Anaphase promoting complex subunit 1 Anaphase promoting complex subunit 7 Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit CDC26 Cell division cycle 16 Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Chromatin licensing and DNA replication factor 1 DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM4 DNA replication licensing factor MCM5 DNA replication licensing factor MCM6 DNA replication licensing factor MCM7 E2 ubiquitin-conjugating enzyme Fizzy/cell division cycle 20 related 1 (Drosophila) GMNN protein Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 S Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A3Q1LHC9 A0A3Q1LIW5 A0A3Q1M862 A0A3Q1MAR8 A0A452DI44 A1A4R8 A4FUD9 A6H7F8 A7MBA2 A7Z061 E1B945 E1BAB6 E1BFZ9 E1BH89 E1BK11 E1BM34 E1BPM5 F1MBI1 F1MLV1 F1MWE0 F1MXE4 F1MYH8 F1N6Z0 F2Z4G9 G3N1P6 G5E589 P0CG53 P0CH28 P33672 P56701 P62194 P62992 P63048 Q17QP9 Q1RML1 Q2KI42 Q2KJ25 Q2KJ46 Q2KJE7 Q2TA10 Q2YDE4 Q32KL2 Q32L05 Q32PA5 Q3MHN0 Q3SX30 Q3SZ19 Q3SZ31 Q3SZC2 Q3SZT7 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3ZBD0 Q3ZBG0 Q3ZBH9 Q3ZCF6 Q3ZCK9 Q56JZ0 Q58DR0 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0	ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ANAPC8 CDC16 CDC23 CDC26 CDC27 CDT1 FZR1 GMNN MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSMF1 RPS27A SUG1 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBCH10 UBE2C UBE2D1 UBE2E1 UBE2S	Bos taurus (cattle)
Galactose catabolism	Galactokinase Galactose-1-phosphate uridylyltransferase UDP-N-acetylglucosamine 4-epimerase	A0A452DIP2 A6H768 Q58CX1	GALE GALK1 GALT	Bos taurus (cattle)	G93924TT
FGFR2c ligand binding and activation	Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor	A0A3Q1LRU7 A0MTF4 D8KXU9 E1BHC1 E1BJU2 E1BP37 F1MHC6 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969	AFGF FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF4A FGF4C FGF5 FGF6 FGF6A FGF7B FGF8 FGF9 FGFA FGFR2 Fgf4 HBGF-1	Bos taurus (cattle)
Attachment of GPI anchor to uPAR	GPAA1 protein GPI inositol-deacylase GPI-anchor transamidase Phosphatidylinositol glycan anchor biosynthesis class S Phosphatidylinositol glycan anchor biosynthesis class T Phosphatidylinositol glycan anchor biosynthesis class U Urokinase plasminogen activator surface receptor	E1BNQ0 F1MSF3 F1N4W0 F1N7F8 Q05588 Q3MHZ7 Q3T0N7	GPAA1 PGAP1 PIGK PIGS PIGT PIGU PLAUR	Bos taurus (cattle)
Dectin-1 mediated noncanonical NF-kB signaling	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin 1 F-box and WD repeat domain containing 11 Inhibitor of nuclear factor kappa-B kinase subunit alpha Mitogen-activated protein kinase kinase kinase 14 NEDD8-activating enzyme E1 catalytic subunit NEDD8-conjugating enzyme Ubc12 NFKB2 protein Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta RELB proto-onco, NF-kB subunit S-phase kinase-associated protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A3Q1M118 A0A3Q1MJI4 A0A452DI44 A0A452DIY4 A3KN22 A7MBA2 A7MBB7 E1BD83 E1BL08 F1MBB0 F1MBI1 F1MLV1 F1MWE0 F1MXE4 F1MYD0 F1MYH8 F1N6Z0 G5E589 P0CG53 P0CH28 P33672 P56701 P62194 P62992 P63048 Q17QP9 Q2KI42 Q2KJ25 Q2KJ46 Q2KJE7 Q2YDE4 Q32KL2 Q3MHN0 Q3SX30 Q3SZ19 Q3SZC2 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3ZBD0 Q3ZBG0 Q3ZCF3 Q3ZCK9 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0 Q95KV1	CHUK CUL1 FBXW11 IKKA MAP3K14 NFKB2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RELB RPS27A SKP1 SKP1A SUG1 TRAP2 UBA3 UBA52 UBA80 UBB UBC UBC12 UBCEP1 UBCEP2 UBE2M	Bos taurus (cattle)
Downstream TCR signaling	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 3-phosphoinositide-dependent protein kinase 1 B-cell CLL/lymphoma 10 BOLA-DQA1 protein BoLA-DR-alpha Caspase recruitment domain family member 11 Cell division cycle 34, ubiqiutin conjugating enzyme Cullin 1 F-box and WD repeat domain containing 11 Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta MALT1 paracaspase MHC class II antigen MHC class II antigen Major histocompatibility complex, class II, DQ alpha 5 Major histocompatibility complex, class II, DY alpha Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator NF-kappa-B inhibitor alpha (Fragment) NF-kappaB transcription factor p65 subunit Nuclear factor NF-kappa-B p105 subunit Phosphatase and tensin homolog Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta Protein kinase C Receptor-interacting serine/threonine-protein kinase 2 S-phase kinase-associated protein 1 T cell receptor associated transmembrane adaptor 1 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TNF receptor-associated factor 6 TRAV29-1*01 Tyrosine-protein kinase Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A3Q1LJT8 A0A3Q1M088 A0A3Q1M118 A0A3Q1M3D2 A0A3Q1MCW9 A0A3Q1MT21 A0A3S5ZPB2 A0A452DI44 A0A452DIY4 A1XG22 A2VDU3 A6H6Y1 A6QQE7 A7MBA2 E1B7Z0 E1BD83 E1BLZ1 E1BMG4 F1MBI1 F1MBS7 F1MDX9 F1MJK4 F1MJU5 F1MKW9 F1ML60 F1MLV1 F1MQJ7 F1MWE0 F1MXE4 F1MYD0 F1MYH8 F1MYM3 F1N0X9 F1N4D3 F1N6Z0 G3MWT2 G5E589 G8JL01 P0CG53 P0CH28 P23726 P23727 P32871 P33672 P56701 P62194 P62992 P63048 Q0VCU4 Q17QJ6 Q17QP9 Q1RMX2 Q28072 Q28073 Q2KI42 Q2KJ25 Q2KJ46 Q2KJE7 Q2TA10 Q2YDE4 Q30309 Q32KL2 Q3MHN0 Q3SX30 Q3SZ19 Q3SZC2 Q3SZJ2 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3ZBD0 Q3ZBG0 Q3ZCC3 Q3ZCF3 Q3ZCK9 Q3ZCM0 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0 Q70IB5 Q8WNW7 Q95KU9 Q95KV0 Q95KV1	BCL10 BLA-DQB BOLA-DQA1 BOLA-DQA2 BOLA-DQA5 BOLA-DRA BOLA-DRB2 BOLA-DRB3 BOLA-DYA BOLA-DYB BoLA-DIB BoLA-DRA BoLA-DYB CARD11 CD247 CD3D CD3E CD3G CD4 CDC34 CHUK CUL1 DYB FBXW11 HLA-DRA IKBKB IKBKG IKKA INPP5D LCK LOC100848815 MALT1 MAP3K7 NEMO NFKB1 NFKBIA PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PRKCQ PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTEN RELA RIPK2 RPS27A SKP1 SKP1A SUG1 TAB2 TRAF6 TRAP2 TRAT1 TRAV29-1 UBA52 UBA80 UBB UBC UBC4 UBCEP1 UBCEP2 UBCH4 UBCH5B UBE2D1 UBE2D2 bIkBa	Bos taurus (cattle)
IFNG signaling activates MAPKs	Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Mitogen-activated protein kinase 1 Mitogen-activated protein kinase Tyrosine-protein kinase Tyrosine-protein kinase	A0A3Q1LLQ7 E1B8P9 E1BCP6 F1MXR5 F1N0D6 P07353 P46196	ERK2 IFNG IFNGR1 IFNGR2 JAK1 JAK2 MAPK1 MAPK3 PRKM1	Bos taurus (cattle)
Generation of second messenger molecules	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma BOLA-DQA1 protein BoLA-DR-alpha CD101 molecule Cytoplasmic protein FYB protein GRB2 related adaptor protein 2 Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Linker for activation of T cells Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) MHC class II antigen MHC class II antigen Major histocompatibility complex, class II, DQ alpha 5 Major histocompatibility complex, class II, DY alpha Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 3 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 TRAV29-1*01 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase non-specific serine/threonine protein kinase	A0A3Q1LSY0 A0A3Q1M088 A0A3Q1M0G8 A0A3Q1M3D2 A0A3Q1MMD9 A0A3Q1MT21 A0A3Q1MTF5 A6H6Y1 A6QQE7 A7YWJ7 A7Z039 E1BKA6 E1BLZ1 E1BMP9 F1MJK4 F1MJU5 F1ML60 F1MYF9 F1MZ60 F1N0X9 G3MWT2 G8JL01 Q08DS6 Q08E52 Q0VCU4 Q1LZB2 Q28072 Q28073 Q30309 Q3ZCM0 Q70IB5	BLA-DQB BOLA-DQA1 BOLA-DQA2 BOLA-DQA5 BOLA-DRA BOLA-DRB2 BOLA-DRB3 BOLA-DYA BOLA-DYB BoLA-DIB BoLA-DRA BoLA-DYB CD101 CD247 CD3D CD3E CD3G CD4 DYB FYB FYB1 GRAP2 HLA-DRA ITK LAT LCK LCP2 LOC100848815 NCK1 PAK1 PAK2 PAK3 PLCG1 PLCG2 TRAV29-1 ZAP70	Bos taurus (cattle)
Inactivation, recovery and regulation of the phototransduction cascade	Calmodulin-like Calmodulin-lysine N-methyltransferase Cyclic nucleotide gated channel subunit beta 1 Cyclic nucleotide-gated channel alpha-1 EF-hand domain-containing protein G protein-coupled receptor kinase G protein-coupled receptor kinase Glycylpeptide N-tetradecanoyltransferase 2 Glycylpeptide N-tetradecanoyltransferase Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(t) subunit alpha-1 Guanine nucleotide-binding protein subunit beta-5 Guanylate cyclase Guanylate cyclase Guanylyl cyclase-activating protein 1 Guanylyl cyclase-activating protein 2 Methionine aminopeptidase 1 Methionine aminopeptidase 2 Phosphodiesterase Phosphodiesterase Protein farnesyltransferase subunit beta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Recoverin Regulator of G-protein signaling 9-binding protein Regulator of G-protein signaling 9 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Rhodopsin kinase GRK1 Rhodopsin S-arrestin Serine/threonine-protein phosphatase with EF-hands	A0A3Q1MR28 A0A3S5ZPL0 A6QLA4 A7YWN4 E1B957 E1BK80 F1MBQ1 F1MH44 F1MLH6 F1MN48 F1MRI0 F1MTS7 F1MWV0 F1MY40 F1MYX4 F1MZK0 F1N081 F1N4Q2 P02698 P02699 P04695 P04972 P08168 P21457 P28327 P46065 P49355 Q00194 Q8MJG0 Q9N181	CALM CAMKMT CNCG CNCG1 CNGA1 CNGB1 FNTA FNTB GCAP1 GNAT1 GNB5 GNGT1 GRK1 GRK4 GRK7 GUCA1 GUCA1A GUCA1B GUCY2D GUCY2F LOC786620 METAP1 METAP2 NMT1 NMT2 PDE6A PDE6B PDE6G PDEG PPEF1 R9AP RCV1 RCVRN RGS9 RGS9BP RHO RHOK SAG	Bos taurus (cattle)
Neurexins and neuroligins	Band 4.1-like protein 5 Calcium/calmodulin dependent serine protein kinase Carboxylesterase type B domain-containing protein DLG associated protein 1 DLG associated protein 3 DLG associated protein 4 Discs large MAGUK scaffold protein 3 Discs large MAGUK scaffold protein 4 Erythrocyte membrane protein band 4.1 like 1 Erythrocyte membrane protein band 4.1 like 2 Erythrocyte membrane protein band 4.1 like 3 Glutamate metabotropic receptor 1 Glutamate metabotropic receptor 5 Homer protein homolog 1 Homer scaffold protein 2 Homer scaffold protein 3 LRRTM2 protein LRRTM3 protein Leucine rich repeat transmembrane neuronal 4 Leucine-rich repeat transmembrane neuronal protein 1 Neurexin 3 Neuroligin 1 Neuroligin 2 Neuroligin 3 Protein 4.1 SH3 and multiple ankyrin repeat domains 1 SH3 and multiple ankyrin repeat domains 3 Sorbin and SH3 domain containing 2 Uncharacterized protein	A0A3Q1LHC4 A0A3Q1LPV4 A0A3Q1LRW9 A0A3Q1LWK1 A0A3Q1MBH0 A0A3Q1MUK3 A0A3Q1MV08 A1A4H9 A6H701 A6QNR7 E1B7S3 E1BBJ2 F1MDE0 F1MEA4 F1MM66 F1MW19 F1N104 F1N119 F1N5I2 F1N611 F6Q4B1 G3MXP5 G3N1H2 G3X7B4 G3X7N7 G5E618 Q2KJ56 Q58CU2 Q9N179	CASK DLG3 DLG4 DLGAP1 DLGAP3 DLGAP4 E41P EPB41 EPB41L1 EPB41L2 EPB41L3 EPB41L5 GRM1 GRM5 HOMER1 HOMER2 HOMER3 LRRTM1 LRRTM2 LRRTM3 LRRTM4 NLGN1 NLGN2 NLGN3 NLGN4X NRXN3 SHANK1 SHANK3 SORBS2	Bos taurus (cattle)
Surfactant metabolism	ATP binding cassette subfamily A member 3 Adenosine receptor A2 Adenosine receptor A2b Adhesion G protein-coupled receptor F5 Alpha-2A adrenergic receptor Alpha-2C adrenergic receptor BoWC1.1 CD163 molecule-like 1 Cytoskeleton associated protein 4 GATA binding protein 6 LIM and cysteine-rich domains protein 1 Napsin A aspartic peptidase P2Y purinoceptor 2 Palmitoyltransferase Pepsin A Pro-cathepsin H Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C Pulmonary surfactant-associated protein D SRCR domain-containing protein SRCR domain-containing protein SRCR domain-containing protein Sodium-dependent phosphate transport protein 2A Surfactant protein A1 Thyroid transcription factor 1-associated protein 26 Transcription termination factor 1 WC1 isolate CH149 WC1 isolate DV10 WC1.3 molecule adenosine deaminase	A0A3Q1LQ48 A0A3Q1LVH8 A0A3Q1MC87 A0A3Q1MPU0 A0A3Q1MQ71 A0A3Q1NJ66 A0A3Q1NNS6 A0A452DJB4 A5PJN1 E1B813 E1B9V4 E1BCR1 E1BJW6 E1BKU0 E3W9A0 F1MBC6 F1MDI7 F1ME65 F1MV32 F1N144 F1N1M2 F1N373 G3MXF3 G3X8C9 P15781 P35246 Q17QE2 Q1LZD0 Q28838 Q3T0I2	ABCA3 ADA2 ADGRF5 ADORA2A ADORA2B ADRA2A ADRA2C CCDC59 CD163L1 CKAP4 CTSH GATA6 LMCD1 LOC101907335 LOC751811 LOC786796 NAPSA P2RY2 PGA5 SFTP3 SFTP4 SFTPA1 SFTPB SFTPC SFTPD SLC34A1 TAP26 TTF1 WC-7 WC1 WC1-12 WC1.3 ZDHHC2	Bos taurus (cattle)
Interleukin-6 signaling	E3 ubiquitin-protein ligase CBL Interleukin 6 cytokine family signal transducer Interleukin 6 receptor Interleukin-6 Signal transducer and activator of transcription Signal transducer and activator of transcription Suppressor of cytokine signaling 3 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type	A0A3Q1LN00 A0A3Q1ME65 E1BCP6 E1BD36 E1BJQ3 F1MCX4 F1MX38 F1N0D6 F1N339 P26892 Q9BEG9	CBL IL6 IL6R IL6ST JAK1 JAK2 PTPN11 SOCS3 STAT1 STAT3 TYK2	Bos taurus (cattle)
A tetrasaccharide linker sequence is required for GAG synthesis	Agrin Beta-1,4-galactosyltransferase Biglycan Brevican core protein Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 (Neuroglycan C) Decorin Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Glypican 2 Glypican 4 Glypican 5 Glypican-1 Glypican-3 Hexosyltransferase Neurocan Syndecan-1 Syndecan-2 Syndecan Versican core protein Xylosyltransferase 1 Xylosyltransferase 2	A0A3Q1LG25 A0A3Q1LSF3 A0A3Q1LTY7 A0A3Q1LZ29 E1BKJ2 E1BKS1 F1MCX1 F1MQ31 F1MQ60 F1MVH6 F1MY84 F1MZX8 F1N211 F1N2Y8 F6Q1U8 P21793 P21809 P81282 Q08DZ5 Q0VCM1 Q3ZBZ6 Q58DD4	AGRN B3GALT6 B3GAT1 B3GAT3 B4GALT7 BCAN BGN CSPG2 CSPG4 CSPG5 DCN GPC1 GPC2 GPC3 GPC4 GPC5 NCAN SDC1 SDC2 SDC4 VCAN XYLT1 XYLT2	Bos taurus (cattle)
Interferon gamma signaling	Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Mitogen-activated protein kinase 1 Mitogen-activated protein kinase Protein kinase C delta type Signal transducer and activator of transcription Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Y-box-binding protein 1 calcium/calmodulin-dependent protein kinase	A0A3Q1LLQ7 A0A3Q1M739 A0A3Q1ME65 A0A3Q1MKC7 A0A3Q1MRR6 E1B8P9 E1BCP6 F1MSN0 F1MXR5 F1N0D6 P07353 P46196 P67808 Q2HJF7 Q3MHJ9 Q9BEG9	CAMK2A CAMK2B CAMK2D ERK2 IFNG IFNGR1 IFNGR2 JAK1 JAK2 MAPK1 MAPK3 PRKCD PRKM1 PTPN6 SOCS1 SOCS3 STAT1 YB1 YBX1	Bos taurus (cattle)
RHO GTPases Activate NADPH Oxidases	Cytochrome b-245 heavy chain Cytochrome b-245 light chain Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase NADPH oxidase 1 NADPH oxidase 3 NADPH oxidase organizer 1 Neutrophil cytosolic factor 1 Neutrophil cytosolic factor 2 Neutrophil cytosolic factor 4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Phosphatidylinositol 3-kinase catalytic subunit type 3 Protein S100-A8 Protein S100-A9 Protein kinase C beta type Protein kinase C delta type Protein kinase C Ras-related C3 botulinum toxin substrate 2 mitogen-activated protein kinase non-specific serine/threonine protein kinase	A0A3Q1LQK4 A0A3Q1LTT9 A0A3Q1MKI4 A0A3Q1MRR6 A0A3Q1MSP9 A0A3Q1MTW8 A0A452DHY1 A6QLW1 E1B8P9 E1BAA4 E1BFF3 E1BPJ7 F1MHS5 G3X793 O46521 O46522 P05126 P28782 P46196 Q5BIN5 Q9TU25	CYBA CYBB ERK2 MAPK1 MAPK11 MAPK14 MAPK3 NCF1 NCF2 NCF4 NOX1 NOX3 NOXO1 PIK3C3 PIK3R4 PIN1 PRKCB PRKCB1 PRKCD PRKCZ PRKM1 RAC2 S100A8 S100A9	Bos taurus (cattle)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Alpha isoform of regulatory subunit A, protein phosphatase 2 Amphiregulin Betacellulin CD19 molecule CD80 molecule CD86 molecule Epiregulin Epithelial mitogen Estrogen receptor beta Estrogen receptor FLT3LG protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 2 GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Immediate early response 3 Inducible T-cell costimulator Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin Interleukin 1 receptor like 1 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-33 Kit ligand Klotho beta Klotho Mast/stem cell growth factor receptor Mitogen-activated protein kinase 1 Mitogen-activated protein kinase Myeloid differentiation primary response protein MyD88 Neuregulin 2 Neuregulin 3 PIP5K1A protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphatidylinositol-4-phosphate 5-kinase type 1 beta Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Phosphatidylinositol-5-phosphate 4-kinase type 2 beta Phosphoinositide-3-kinase adaptor protein 1 Phosphoinositide-3-kinase regulatory subunit 3 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Pro-neuregulin-1, membrane-bound isoform Proheparin-binding EGF-like growth factor Protein phosphatase 2 scaffold subunit Abeta Proto-oncogene vav Ras homolog family member G Ras-related C3 botulinum toxin substrate 2 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Striatin T cell receptor associated transmembrane adaptor 1 T-cell-specific surface glycoprotein CD28 TNF receptor-associated factor 6 Transforming growth factor alpha Tyrosine-protein kinase Fyn Tyrosine-protein kinase receptor Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A3Q1LRU7 A0A3Q1LUE0 A0A3Q1M3Q3 A0A3Q1M535 A0A3Q1M7J4 A0A3Q1M864 A0A3Q1MBL1 A0A3Q1MCW9 A0A3Q1ME99 A0A3Q1MGW7 A0A3Q1MHB0 A0A3Q1MKB4 A0A3Q1MLL9 A0A3Q1MPT9 A0A3Q1N3Z8 A0A3Q1NAV6 A0A3Q1ND77 A0A3S5ZP81 A0A452DHW6 A0A452DHX3 A0JNB0 A0MTF4 A2VDZ0 A2VE24 A2VE27 A4FV68 A5D973 A5PJB2 A6QLC5 A6QLU3 A6QR62 B1H0W5 D8KXU9 E1B7I9 E1B8P9 E1BAI2 E1BBE2 E1BDM2 E1BE66 E1BFL8 E1BFP8 E1BGY3 E1BHC1 E1BIM8 E1BIN8 E1BJU2 E1BP37 F1MCQ7 F1MDQ5 F1MEV4 F1MHC6 F1MHR4 F1MHT2 F1MJE0 F1MN51 F1MPD0 F1MQN0 F1MRU0 F1MRU1 F1MS28 F1MV64 F1MYE0 F1MYM3 F1MZD6 F1N1S8 F1N339 F1N4S9 F1N586 F1N6G8 F1N7M1 F2Z4J0 G3MXR4 G3N104 G3XGD3 P03968 P03969 P23726 P23727 P32871 P46196 P49884 P67774 Q08DN7 Q08DP7 Q08DU3 Q0P594 Q0P5F7 Q0P5G7 Q1RMI2 Q1RMT8 Q28132 Q2KJ15 Q2LGB3 Q3T0F9 Q3ZCC3 Q3ZCM0 Q58DF9 Q9TU25 Q9XSB5 Z4YHD9	AFGF AREG BTC CD19 CD28 CD80 CD86 EGFR EPGN ERBB2 ERBB3 ERBB4 EREG ERK2 ESR ESR1 ESR2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF8A FGF9 FGFA FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 FYN Fgf4 GAB1 GAB2 GRB2 HBEGF HBGF-1 HGF ICOS IER3 IL1RL1 IL33 INS INSR IRAK1 IRAK4 IRS1 IRS2 KIT KITLG KL KLB LCK MAPK1 MAPK3 MET MYD88 NR3A1 NR3A2 NRG1 NRG2 NRG3 PDGFA PDGFB PDGFRA PDGFRB PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5K2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5D PPP2R5E PRKM1 PTPN11 RAC2 RHOG SCF SRC STRN TGFA TRAF6 TRAT1 VAV1	Bos taurus (cattle)

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