GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **426 - 450** of **557** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Interleukin-6 signaling	E3 ubiquitin-protein ligase CBL Interleukin 6 cytokine family signal transducer Interleukin 6 receptor Interleukin-6 Signal transducer and activator of transcription Signal transducer and activator of transcription Suppressor of cytokine signaling 3 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type	A0A3Q1LN00 A0A3Q1ME65 E1BCP6 E1BD36 E1BJQ3 F1MCX4 F1MX38 F1N0D6 F1N339 P26892 Q9BEG9	CBL IL6 IL6R IL6ST JAK1 JAK2 PTPN11 SOCS3 STAT1 STAT3 TYK2	Bos taurus (cattle)
EPH-Ephrin signaling	EFNA2 protein EFNA4 protein EPH receptor A10 EPH receptor B6 EPH-related receptor tyrosine kinase ligand 7 Ephrin A3 Ephrin B2 Ephrin B3 Ephrin type-B receptor 3 Ephrin-A1 Ephrin-B1 receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase	A0A3Q1LXH4 A0A3Q1MAA9 A0A3Q1MJW2 A1L570 A5D7J8 A6QLY0 E1BER5 E1BIE4 E1BJ31 E1BJS9 F1MII5 F1ML02 F1N0M5 F1N163 F1N3R6 F1N5D4 F1N6H6 F1N780 Q17R05 Q3ZC64	EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6	Bos taurus (cattle)
Toll Like Receptor 9 (TLR9) Cascade	Early endosome antigen 1 Phosphatidylinositol 3-kinase catalytic subunit type 3 Toll-like receptor 9 non-specific serine/threonine protein kinase	A0A3Q1LQK4 A0A3Q1M5J6 A5H631 A6QLW1	EEA1 PIK3C3 PIK3R4 TLR9	Bos taurus (cattle)
Vitamin B2 (riboflavin) metabolism	Ectonucleotide pyrophosphatase/phosphodiesterase 1 FAD synthase Riboflavin transporter Solute carrier family 52, riboflavin transporter, member 3 Tartrate-resistant acid phosphatase type 5 riboflavin kinase	A0A3Q1MPJ2 A0A3Q1N6I5 E1B8A0 F1MNS5 F6R223 Q5E9R1	ACP5 ENPP1 FLAD1 RFK RFT2 SLC52A2 SLC52A3	Bos taurus (cattle)
Elastic fibre formation	Elastin Fibrillin 2 Fibrillin-1 Fibulin-5 Integrin beta-6 Integrin beta Integrin beta Integrin subunit alpha V Lysyl oxidase homolog 2 Lysyl oxidase homolog Lysyl oxidase homolog Microfibril associated protein 5 furin protein-lysine 6-oxidase protein-lysine 6-oxidase	A0A140T828 A0A140T8D2 A0A3Q1M1V6 A0A3Q1MEV3 A0A3Q1MXS2 A0JNB6 A5D7S7 A6H737 B0JYR0 E1BFC8 F1MTN1 F1MTZ4 G1K200 P98133 Q8SQB8	ELN FBLN5 FBN1 FBN2 FURIN ITGAV ITGB1 ITGB3 ITGB6 LOX LOXL1 LOXL2 LOXL3 LOXL4 MFAP5	Bos taurus (cattle)
Cellular response to hypoxia	Endothelial PAS domain protein 1 Hypoxia inducible factor 1 subunit alpha inhibitor Hypoxia-inducible factor 1-alpha	A0A3Q1MIU5 A0JND0 F1MG82	EPAS1 HIF1A HIF1AN	Bos taurus (cattle)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	Erythropoietin receptor Erythropoietin GRB2-associated-binding protein 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphoinositide 3-kinase regulatory subunit 5 Tyrosine-protein kinase Tyrosine-protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A3Q1M2L5 A6QLU3 E1BCP6 E1BCV1 E1BE66 F1MEQ7 F1MJE0 F1MYM3 F1N261 P23727 P32871 P48617	EPO EPOR GAB1 IRS2 JAK2 LYN PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R5	Bos taurus (cattle)
Signaling by Erythropoietin	Erythropoietin receptor Insulin receptor substrate 2 Tyrosine-protein kinase Tyrosine-protein kinase	E1BCP6 F1MEQ7 F1MJE0 F1N261	EPOR IRS2 JAK2 LYN	Bos taurus (cattle)
ESR-mediated signaling	Estrogen receptor beta Estrogen receptor Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Prostaglandin E synthase 3 Serine/threonine-protein phosphatase peptidylprolyl isomerase peptidylprolyl isomerase	A0A452DIU3 F1MU79 F1N719 G3MXV0 P49884 Q76LV1 Q76LV2 Q9XSB5	ESR ESR1 ESR2 FKBP4 FKBP5 HSP90A HSP90AA1 HSP90AB1 HSPC3 HSPCA HSPCB NR3A1 NR3A2 PPP5C PTGES3	Bos taurus (cattle)
Nuclear signaling by ERBB4	Estrogen receptor Gamma-secretase subunit APH-1 Gamma-secretase subunit APH-1 Gamma-secretase subunit PEN-2 Nicastrin Presenilin-1 Presenilin-2 Receptor protein-tyrosine kinase Signal transducer and activator of transcription 5A Tyrosine-protein kinase WW domain-containing oxidoreductase Yes1 associated transcriptional regulator	A0A3Q1LNM1 A0A3Q1LVN4 A0A3Q1MBH7 A0A3Q1MDC6 A0A3Q1MKB4 E1BIM8 F1MK73 P49884 Q5G235 Q95115 Q9XT96 Q9XT97	APH1A APH1B ERBB4 ESR ESR1 MGF NCSTN NR3A1 PEN2 PSEN1 PSEN2 PSENEN SRC STAT5A WWOX YAP1	Bos taurus (cattle)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen-activated protein kinase kinase kinase 1 TIR domain containing adaptor protein TNF receptor-associated factor 6	A0A3Q1M4J2 E1B847 Q3SX05 Q3ZCC3	ECSIT MAP3K1 TIRAP TRAF6	Bos taurus (cattle)
MyD88 cascade initiated on plasma membrane	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen-activated protein kinase kinase kinase 1 TNF receptor-associated factor 6	E1B847 Q3SX05 Q3ZCC3	ECSIT MAP3K1 TRAF6	Bos taurus (cattle)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen-activated protein kinase kinase kinase 1 TNF receptor-associated factor 6	E1B847 Q3SX05 Q3ZCC3	ECSIT MAP3K1 TRAF6	Bos taurus (cattle)
Class C/3 (Metabotropic glutamate/pheromone receptors)	Extracellular calcium-sensing receptor Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2 Glutamate metabotropic receptor 1 Glutamate metabotropic receptor 2 Glutamate metabotropic receptor 4 Glutamate metabotropic receptor 5 Glutamate metabotropic receptor 6 Glutamate metabotropic receptor 7 Glutamate metabotropic receptor 8 Metabotropic glutamate receptor 3 Taste 1 receptor member 1 Taste receptor type 1 member 2 Taste receptor type 1 member 3 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2	A0A3Q1LJN2 A0A3Q1LRA2 A0A3Q1LZA1 A0A3Q1MIP5 A0A3Q1ML22 A0A3Q1N090 A0A3Q1N0Q7 A0A3Q1NND8 A5D7D8 E1B8B7 E1B965 E1BAB4 E1BLE8 E1BPM8 F1MDE0 F1MF15 F1MIZ5 F1MP17 F1MVK0 F1N213 F1N2G6 F1N5V2 G3N1H2 P35384 Q2ABB1 Q2ABB3 Q2ABC0 Q2ABC3 Q2ABC4 Q2ABC5	CASR GABBR1 GABBR2 GPRC2A GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 LOC782957 PCAR1 T2R10C T2R65A TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R16 TAS2R3 TAS2R39 TAS2R4 TAS2R40 TAS2R42 TAS2R46 TAS2R60 TAS2R7 TAS2R8	Bos taurus (cattle)	G58161NS
Fc epsilon receptor (FCERI) signaling	FCER1A protein High affinity immunoglobulin epsilon receptor subunit gamma Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein Linker for activation of T cells Membrane spanning 4-domains A2 Tyrosine-protein kinase Tyrosine-protein kinase	A0A3Q1LKV0 A0A3Q1MHG9 A6QQQ4 E1BNU1 F1MZ60 F1N261 G3N342 Q9BDR7	FCER1A FCER1G LAT LYN MS4A2 SYK	Bos taurus (cattle)
VEGF binds to VEGFR leading to receptor dimerization	FIGF protein Placenta growth factor Vascular endothelial growth factor A Vascular endothelial growth factor B Vascular endothelial growth factor C Vascular endothelial growth factor receptor 2 Vascular endothelial growth factor receptor 3 receptor protein-tyrosine kinase	A7MBB6 F1MDD9 F1MHP5 F1MWF1 P15691 Q9XS47 Q9XS49 Q9XS50	FIGF FLT1 FLT4 KDR PGF PLGF VEGF VEGFA VEGFB VEGFC VEGFD VRF	Bos taurus (cattle)
VEGF ligand-receptor interactions	FIGF protein Placenta growth factor Vascular endothelial growth factor A Vascular endothelial growth factor B Vascular endothelial growth factor C	A7MBB6 P15691 Q9XS47 Q9XS49 Q9XS50	FIGF PGF PLGF VEGF VEGFA VEGFB VEGFC VEGFD VRF	Bos taurus (cattle)
PI3K Cascade	FLT3LG protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 2 GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Klotho beta Klotho Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A3Q1LQK4 A0A3Q1LRU7 A0A3Q1LUE0 A0A3Q1M3Q3 A0A3Q1M864 A0A3Q1MPT9 A0A3Q1NAV6 A0MTF4 A2VE24 A5H631 A6QLU3 A6QLW1 D8KXU9 E1B7I9 E1BAI2 E1BFP8 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1MHC6 F1MJE0 F1MN51 F1MRU0 F1MYE0 F1MYM3 F1N339 F1N4S9 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969 P23726 P23727 P32871 Q3T0F9	AFGF FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF8A FGF9 FGFA FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 Fgf4 GAB1 GAB2 GRB2 HBGF-1 IRS1 IRS2 KL KLB PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN11 TLR9	Bos taurus (cattle)
FRS-mediated FGFR2 signaling	FRS3 protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase NRas Growth factor receptor-bound protein 2 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type small monomeric GTPase	A0A3Q1LRU7 A0A3Q1M3Q3 A0A3Q1NAV6 A0MTF4 A5D7R9 A6H792 D8KXU9 E1B7I9 E1BGY3 E1BHC1 E1BJU2 E1BMX0 E1BP37 F1MHC6 F1N339 F1N6G8 F1N7C3 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969 Q3T0F9	AFGF FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF9 FGFA FGFR2 FRS2 FRS3 Fgf4 GRB2 HBGF-1 KRAS NRAS PTPN11 SOS1	Bos taurus (cattle)
FRS-mediated FGFR1 signaling	FRS3 protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase NRas Growth factor receptor-bound protein 2 Klotho SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type small monomeric GTPase	A0A3Q1LUE0 A0A3Q1NAV6 A0MTF4 A5D7R9 A6H792 D8KXU9 E1B7I9 E1BAI2 E1BGY3 E1BHC1 E1BJU2 E1BMX0 E1BP37 F1N339 F1N6G8 F1N7C3 G3MXR4 G3XGD3 P03968 P03969 Q3T0F9	AFGF FGF1 FGF10 FGF17 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF5 FGF5C FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 FRS2 FRS3 Fgf4 GRB2 HBGF-1 KL KRAS NRAS PTPN11 SOS1	Bos taurus (cattle)
FRS-mediated FGFR3 signaling	FRS3 protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase NRas Growth factor receptor-bound protein 2 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type small monomeric GTPase	A0A3Q1MPT9 A0MTF4 A5D7R9 A6H792 D8KXU9 E1B7I9 E1BJU2 E1BMX0 E1BP37 F1MHC6 F1N339 F1N6G8 F1N7C3 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969 Q3T0F9	AFGF FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF4A FGF4C FGF5 FGF6A FGF8 FGF9 FGFA FGFR3 FRS2 FRS3 Fgf4 GRB2 HBGF-1 KRAS NRAS PTPN11 SOS1	Bos taurus (cattle)
FCGR activation	Fc fragment of IgG receptor IIb Fc fragment of IgG receptor Ia Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein Low affinity immunoglobulin gamma Fc region receptor III-A T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain Tyrosine-protein kinase Fyn Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase	A0A3Q1LKV0 A0A3Q1LPG0 A0A3Q1M3L6 A0A3Q1MHG9 A0A3Q1MYA3 A0A3S5ZP99 A0JNB0 A5PKG9 A7MB57 E1BIM8 F1MHH9 F1N261 G3N0V0 G8JL01 P79107 Q0VCU4	CD247 CD3G FCGR1A FCGR2B FCGR3 FCGR3A FCGRIII FGR FYN LYN SRC SYK YES1	Bos taurus (cattle)
FGFR2b ligand binding and activation	Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor receptor Fibroblast growth factor-binding protein 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor	A0A3Q1LRU7 A0A3Q1M3Q3 A0A3Q1NAV6 E1BGY3 P03968 P03969 Q9MZ06	AFGF FGF1 FGF10 FGF2 FGF3 FGF5B FGF5C FGF7 FGFA FGFBP FGFBP1 FGFR2 HBGF-1	Bos taurus (cattle)
FGFR1b ligand binding and activation	Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor	A0A3Q1LUE0 A0A3Q1NAV6 E1BGY3 P03968 P03969	AFGF FGF1 FGF10 FGF2 FGF3 FGF5C FGFA FGFR1 HBGF-1	Bos taurus (cattle)
PI-3K cascade:FGFR2	Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type	A0A3Q1LRU7 A0A3Q1M3Q3 A0A3Q1NAV6 A0MTF4 A6QLU3 D8KXU9 E1B7I9 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1MHC6 F1N339 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969 P23727 P32871 Q3T0F9	AFGF FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF9 FGFA FGFR2 FRS2 Fgf4 GAB1 GRB2 HBGF-1 PIK3CA PIK3R1 PTPN11	Bos taurus (cattle)

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