GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **451 - 475** of **557** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲	Organism	GlyTouCan ID
Signaling by Erythropoietin	Erythropoietin receptor Insulin receptor substrate 2 Tyrosine-protein kinase Tyrosine-protein kinase	E1BCP6 F1MEQ7 F1MJE0 F1N261	EPOR IRS2 JAK2 LYN	Bos taurus (cattle)
IFNG signaling activates MAPKs	Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Mitogen-activated protein kinase 1 Mitogen-activated protein kinase Tyrosine-protein kinase Tyrosine-protein kinase	A0A3Q1LLQ7 E1B8P9 E1BCP6 F1MXR5 F1N0D6 P07353 P46196	ERK2 IFNG IFNGR1 IFNGR2 JAK1 JAK2 MAPK1 MAPK3 PRKM1	Bos taurus (cattle)
MAPK1 (ERK2) activation	Dual specificity mitogen-activated protein kinase kinase 2 Interleukin 6 cytokine family signal transducer Interleukin 6 receptor Interleukin-6 Mitogen-activated protein kinase 1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type	A0A3S5ZPX3 E1BCP6 E1BD36 E1BJQ3 F1MCX4 F1N0D6 F1N339 P26892 P46196	ERK2 IL6 IL6R IL6ST JAK1 JAK2 MAP2K2 MAPK1 PRKM1 PTPN11 TYK2	Bos taurus (cattle)
ESR-mediated signaling	Estrogen receptor beta Estrogen receptor Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Prostaglandin E synthase 3 Serine/threonine-protein phosphatase peptidylprolyl isomerase peptidylprolyl isomerase	A0A452DIU3 F1MU79 F1N719 G3MXV0 P49884 Q76LV1 Q76LV2 Q9XSB5	ESR ESR1 ESR2 FKBP4 FKBP5 HSP90A HSP90AA1 HSP90AB1 HSPC3 HSPCA HSPCB NR3A1 NR3A2 PPP5C PTGES3	Bos taurus (cattle)
Extrinsic Pathway of Fibrin Clot Formation	Coagulation factor IX Coagulation factor VII Coagulation factor X Tissue factor pathway inhibitor Tissue factor	A0A3Q1NLA0 A0A452DIP8 F1MBC5 P22457 P30931	F10 F3 F7 F9 TFPI	Bos taurus (cattle)
Tight junction interactions	Junctional adhesion molecule A Par-3 family cell polarity regulator Par-6 family cell polarity regulator alpha Par-6 family cell polarity regulator beta Par-6 family cell polarity regulator gamma Protein kinase C	A0A3Q1LS90 A0A3Q1M590 A0A3Q1MIH4 F1MQ96 F6RHP0 Q9XT56	F11R JAM1 PARD3 PARD6A PARD6B PARD6G PRKCI	Bos taurus (cattle)
Platelet Aggregation (Plug Formation)	Glycoprotein IX platelet Glycoprotein Ib platelet subunit beta Glycoprotein V platelet Prothrombin von Willebrand factor	A0A452DI66 E1B863 E1BG29 F1N0R5 F1N1G4	F2 GP1BB GP5 GP9 VWF	Bos taurus (cattle)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	Coagulation factor VIII Protein-S-isoprenylcysteine O-methyltransferase Protein-tyrosine sulfotransferase 2 Protein-tyrosine sulfotransferase protein-ribulosamine 3-kinase	G3N1V4 G5E5W1 Q08DH2 Q0P592 Q3SYY2	F8 FN3KRP ICMT TPST1 TPST2	Bos taurus (cattle)
Fc epsilon receptor (FCERI) signaling	FCER1A protein High affinity immunoglobulin epsilon receptor subunit gamma Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein Linker for activation of T cells Membrane spanning 4-domains A2 Tyrosine-protein kinase Tyrosine-protein kinase	A0A3Q1LKV0 A0A3Q1MHG9 A6QQQ4 E1BNU1 F1MZ60 F1N261 G3N342 Q9BDR7	FCER1A FCER1G LAT LYN MS4A2 SYK	Bos taurus (cattle)
Ficolins bind to repetitive carbohydrate structures on the target cell surface	Ficolin-2 MBL associated serine protease 1 MBL associated serine protease 2	E1BJ49 F1MVS9 Q5I2E5	FCN2 MASP1 MASP2	Bos taurus (cattle)	G49108TO G57321FI
GDP-fucose biosynthesis	Fucose kinase Fucose-1-phosphate guanylyltransferase GDP-L-fucose synthase GDP-fucose transporter 1 GDP-mannose 4,6-dehydratase	A0A3Q1M2A1 A0A3Q1M4E5 A6QM03 E1B9U5 Q3ZBY8	FCSK FPGT FUCT1 GFUS GMDS SLC35C1	Bos taurus (cattle)	G85196CF G96881BQ
Signaling by SCF-KIT	GRB2 associated binding protein 2 GRB2 related adaptor protein 2 GRB2-related adapter protein GTPase NRas Growth factor receptor bound protein 10 Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 7 Kit ligand Mast/stem cell growth factor receptor Matrix metalloproteinase-9 Peptidase S1 domain-containing protein Peptidase S1 domain-containing protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphoinositide-3-kinase regulatory subunit 3 Proto-oncogene vav SOS Ras/Rac guanine nucleotide exchange factor 1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Fyn Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type protein-tyrosine-phosphatase small monomeric GTPase	A0A140T878 A0A3Q1LNN8 A0A3Q1M864 A0A3Q1ME65 A0A452DHX3 A0JNB0 A5D7R9 A6QLK6 A7MB57 E1B8U1 E1BCP6 E1BIM8 E1BIP7 E1BKA6 E1BMX0 E1BNE0 F1MD22 F1MDQ5 F1MSH3 F1MX38 F1N261 F1N339 F1N7C3 P23726 P23727 P32871 P52176 Q08DN7 Q1RMW5 Q28132 Q3T0F9 Q3ZCM0 Q5E9H3 Q95115	FER FES FYN GAB2 GRAP GRAP2 GRB10 GRB2 GRB7 JAK2 KIT KITLG KRAS LCK LOC100139881 LOC540321 LYN MGF MMP9 NRAS PIK3CA PIK3R1 PIK3R2 PIK3R3 PTPN11 PTPRU SCF SOS1 SRC STAT1 STAT3 STAT5A STAT5B TEC VAV1 YES1	Bos taurus (cattle)
Sema3A PAK dependent Axon repulsion	Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta LIM domain kinase 1 Neuropilin Plexin A1 Plexin A2 Plexin A3 Plexin A4 Semaphorin 3A Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase non-specific serine/threonine protein kinase	A0A3Q1LSY0 A0A3Q1M0G8 A0JNB0 E1BC64 E1BFR4 E1BMX5 F1MEW1 F1MIH8 F1N173 F1N2P7 Q08E52 Q5E9H3 Q76LV1 Q76LV2	FES FYN HSP90A HSP90AA1 HSP90AB1 HSPC3 HSPCA HSPCB LIMK1 NRP1 PAK1 PAK2 PAK3 PLXNA1 PLXNA2 PLXNA3 PLXNA4 SEMA3A	Bos taurus (cattle)
FGFRL1 modulation of FGFR1 signaling	Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor like 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor	A0A3Q1NAV6 A0MTF4 E1BGY3 E1BJU2 F1MQI5 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03969	FGF10 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF5C FGF6A FGF8 FGFRL1 Fgf4	Bos taurus (cattle)
Syndecan interactions	Fibroblast growth factor 2 Integrin beta Integrin beta Integrin beta Integrin beta Integrin subunit alpha 2 Integrin subunit alpha 6 Integrin subunit alpha V Syndecan-1 Syndecan-2 Syndecan Transforming growth factor beta-1 proprotein Vitronectin	A0A140T8D2 A0A3Q1M8K4 A0A3Q1MRM3 A0A3Q1MXS2 A0A3Q1N449 E1BKS1 F1MBA3 F1MTN1 P03969 Q08DZ5 Q3ZBS7 Q58DD4 Q8SQB9	FGF2 ITGA2 ITGA6 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 SDC1 SDC2 SDC4 TGFB1 VTN	Bos taurus (cattle)
Cellular hexose transport	Fibroblast growth factor Major facilitator superfamily domain containing 4B Na+/glucose cotransporter 2 Sodium/glucose cotransporter 1 Sodium/mannose cotransporter SLC5A10 Solute carrier family 2 member 11 Solute carrier family 2 member 6 Solute carrier family 2 member 8 Solute carrier family 2 member 9 Solute carrier family 2, facilitated glucose transporter member 12 Solute carrier family 2, facilitated glucose transporter member 1 Solute carrier family 2, facilitated glucose transporter member 2 Solute carrier family 2, facilitated glucose transporter member 3 Solute carrier family 2, facilitated glucose transporter member 3 Solute carrier family 2, facilitated glucose transporter member 4 Solute carrier family 45 member 3 Solute carrier family 5 member 4 Solute carrier family 5 member 9	A0A3Q1MA30 A0A3Q1MQD9 A2VDL2 E1B749 E1BDA6 E1BLB0 E1BMB9 F1MD24 F1MIV2 F1MPC8 F1MRS7 F1MZY9 F1N4B2 P27674 P58351 Q27994 Q6R4Q5 Q6XUI1	FGF21 FGF8C GLUT1 GLUT2 GLUT4 MFSD4B SGLT5 SLC2A1 SLC2A11 SLC2A12 SLC2A2 SLC2A3 SLC2A4 SLC2A6 SLC2A8 SLC2A9 SLC45A3 SLC5A1 SLC5A10 SLC5A2 SLC5A4 SLC5A9	Bos taurus (cattle)	G58161NS G70323CJ
FGFR1c and Klotho ligand binding and activation	Fibroblast growth factor 23 Fibroblast growth factor receptor Klotho	A0A3Q1LUE0 E1BAI2 E1BJU2	FGF23 FGFR1 KL	Bos taurus (cattle)
VEGF binds to VEGFR leading to receptor dimerization	FIGF protein Placenta growth factor Vascular endothelial growth factor A Vascular endothelial growth factor B Vascular endothelial growth factor C Vascular endothelial growth factor receptor 2 Vascular endothelial growth factor receptor 3 receptor protein-tyrosine kinase	A7MBB6 F1MDD9 F1MHP5 F1MWF1 P15691 Q9XS47 Q9XS49 Q9XS50	FIGF FLT1 FLT4 KDR PGF PLGF VEGF VEGFA VEGFB VEGFC VEGFD VRF	Bos taurus (cattle)
VEGF ligand-receptor interactions	FIGF protein Placenta growth factor Vascular endothelial growth factor A Vascular endothelial growth factor B Vascular endothelial growth factor C	A7MBB6 P15691 Q9XS47 Q9XS49 Q9XS50	FIGF PGF PLGF VEGF VEGFA VEGFB VEGFC VEGFD VRF	Bos taurus (cattle)
Extracellular matrix organization	Fibronectin	G5E5A9	FN1	Bos taurus (cattle)
Antagonism of Activin by Follistatin	Follistatin Inhibin beta A chain Inhibin beta B chain	A0A3Q1LMU4 P07995 P50291	FST INHBA INHBB	Bos taurus (cattle)
Regulation of FZD by ubiquitination	Frizzled class receptor 5 Frizzled class receptor 8 Frizzled-6 Leucine rich repeat containing G protein-coupled receptor 5 Low-density lipoprotein receptor-related protein Low-density lipoprotein receptor-related protein Polyubiquitin-B Polyubiquitin-C Protein Wnt R-spondin 1 R-spondin 2 R-spondin 4 R-spondin-3 RING-type E3 ubiquitin transferase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein ubiquitinyl hydrolase 1	A0A3Q1LTW2 A0A3Q1MA92 A0A452DIK6 E1BNT4 F1MDE1 F1ME23 F1MGM1 F1MH47 F1MP23 F1N1K8 F6RLD1 P0CG53 P0CH28 P62992 P63048 Q0IIM6 Q1RMU1	FZD5 FZD6 FZD8 LGR5 LRP5 LRP6 RNF43 RPS27A RSPO1 RSPO2 RSPO3 RSPO4 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 USP8 WNT3A	Bos taurus (cattle)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	ATP-sensitive inward rectifier potassium channel 12 G protein subunit beta 3 G protein subunit gamma 13 G protein-activated inward rectifier potassium channel 1 G protein-activated inward rectifier potassium channel 2 G protein-activated inward rectifier potassium channel 4 GNB4 protein Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein subunit beta-5 Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Inward rectifier potassium channel 2 KCNJ10 protein KCNJ15 protein Potassium inwardly rectifying channel subfamily J member 16 Potassium inwardly rectifying channel subfamily J member 4	A0A3Q1M4V6 A0A3Q1NGS8 A0A3S5ZPL0 A2VDQ4 A4IFL6 A5PJL2 A5PKD6 E1B8Q3 E1BNE9 F1MF15 F1MIZ5 F1MUD1 F1MYR9 F1MYW8 O19182 P02698 P11017 P30671 P50154 P62871 P63212 P63214 P63217 Q0VD28 Q28024 Q3SZ98 Q4TZY1 Q5E9F0	GABBR1 GABBR2 GIRK1 GIRK4 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT12 GNGT2 GNGT3 GNGT5 GNGT7 GNGT8 IRK1 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6	Bos taurus (cattle)
Activation of G protein gated Potassium channels	ATP-sensitive inward rectifier potassium channel 12 G protein subunit beta 3 G protein subunit gamma 13 G protein-activated inward rectifier potassium channel 1 G protein-activated inward rectifier potassium channel 2 G protein-activated inward rectifier potassium channel 4 GNB4 protein Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein subunit beta-5 Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Inward rectifier potassium channel 2 KCNJ10 protein KCNJ15 protein Potassium inwardly rectifying channel subfamily J member 16 Potassium inwardly rectifying channel subfamily J member 4	A0A3Q1M4V6 A0A3Q1NGS8 A0A3S5ZPL0 A2VDQ4 A4IFL6 A5PJL2 A5PKD6 E1B8Q3 E1BNE9 F1MF15 F1MIZ5 F1MUD1 F1MYR9 F1MYW8 O19182 P02698 P11017 P30671 P50154 P62871 P63212 P63214 P63217 Q0VD28 Q28024 Q3SZ98 Q4TZY1 Q5E9F0	GABBR1 GABBR2 GIRK1 GIRK4 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT12 GNGT2 GNGT3 GNGT5 GNGT7 GNGT8 IRK1 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6	Bos taurus (cattle)
GABA B receptor activation	Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2	F1MF15 F1MIZ5	GABBR1 GABBR2	Bos taurus (cattle)

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