GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **501 - 525** of **557** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲	Organism	GlyTouCan ID
IRS-related events triggered by IGF1R	Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin receptor substrate 4 Insulin-like growth factor I Insulin-like growth factor II Tyrosine-protein kinase receptor	F1MGG8 F1MJE0 F1MYE0 G1K218 P07455 P07456	IGF1 IGF1R IGF2 IRS1 IRS2 IRS4	Bos taurus (cattle)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Insulin-like growth factor I Insulin-like growth factor II Tyrosine-protein kinase receptor	G1K218 P07455 P07456	IGF1 IGF1R IGF2	Bos taurus (cattle)
TP53 Regulates Transcription of Death Receptors and Ligands	Insulin-like growth factor-binding protein 3 receptor Insulin-like growth factor-binding protein 3	P20959 Q1JQE1	IGFBP3 TMEM219	Bos taurus (cattle)
NF-kB is activated and signals survival	Beta-nerve growth factor Inhibitor of nuclear factor kappa-B kinase subunit beta Interleukin-1 receptor-associated kinase 1 NF-kappa-B inhibitor alpha (Fragment) NF-kappaB transcription factor p65 subunit NGFR protein Nuclear factor NF-kappa-B p105 subunit Polyubiquitin-B Polyubiquitin-C Sequestosome 1 TNF receptor-associated factor 6 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A3Q1LP06 A0A3Q1LVE4 A1XG22 A5PJV7 F1MKW9 P0CG53 P0CH28 P62992 P63048 Q2LGB3 Q3ZCC3 Q8WNW7 Q95KV0	IKBKB IRAK1 NFKB1 NFKBIA NGF NGFR RELA RPS27A SQSTM1 TRAF6 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 bIkBa	Bos taurus (cattle)
SUMOylation of immune response proteins	Inhibitor of nuclear factor kappa B kinase subunit epsilon NF-kappa-B essential modulator NF-kappa-B inhibitor alpha (Fragment) NF-kappaB transcription factor p65 subunit NFKB2 protein PIAS3 protein PIAS4 protein RING-type E3 ubiquitin transferase Rad60/SUMO-like domain-containing protein Rad60/SUMO-like domain-containing protein SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 3	A0A3Q1LUL4 A0A3Q1M2W5 A1XG22 A4FV15 A6QQU9 A7MBB7 F1MQ36 F1N329 G3MZL6 Q17QV3 Q8WNW7 Q95KU9	IKBKE IKBKG NEMO NFKB2 NFKBIA PIAS3 PIAS4 RELA SUMO3 TOPORS bIkBa	Bos taurus (cattle)
Interleukin-2 signaling	Cytokine receptor common subunit gamma Interleukin-2 receptor subunit alpha Interleukin-2 SHC-transforming protein 1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase non-specific protein-tyrosine kinase	A0A140T878 A0A3Q1LVP1 A0A3Q1MHG9 A2VE30 E1BEL4 F1N0D6 P05016 Q0IIE2 Q3ZCM0 Q95115 Q95118	IL-2 IL2 IL2RA IL2RG JAK1 JAK3 LCK MGF PTK2B SHC1 STAT5A STAT5B SYK	Bos taurus (cattle)
Interleukin-12 signaling	Interleukin 12 receptor subunit beta 1 Interleukin 12 receptor subunit beta 2 Interleukin-12 subunit alpha Interleukin-12 subunit beta Protein disulfide-isomerase Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase	A0A3Q1LXM0 E1BCP6 F1MCX4 F1MEB5 F1N0D6 F1N0R2 F6Q9Q9 G3MX29 P54349	IL12A IL12B IL12RB1 IL12RB2 JAK1 JAK2 P4HB STAT4 TYK2	Bos taurus (cattle)
Interleukin-21 signaling	Cytokine receptor common subunit gamma Interleukin 21 receptor Interleukin Signal transducer and activator of transcription 5A Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase	A0A140T878 A0A3Q1ME65 E1BBE5 E1BEL4 F1MX38 F1MZV7 F1N0D6 F1N0R2 Q95115 Q95118	IL21 IL21R IL2RG JAK1 JAK3 MGF STAT1 STAT3 STAT4 STAT5A STAT5B	Bos taurus (cattle)
Interleukin-9 signaling	Cytokine receptor common subunit gamma Interleukin 9 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase	A0A140T878 A0A3Q1ME65 E1BEL4 E1BF10 F1MX38 F1N0D6 Q95115 Q95118	IL2RG IL9 JAK1 JAK3 MGF STAT1 STAT3 STAT5A STAT5B	Bos taurus (cattle)
Signaling by Insulin receptor	Insulin Tyrosine-protein kinase receptor	A5PJB2 F1MV64	INS INSR	Bos taurus (cattle)
Phase 4 - resting membrane potential	ATP-sensitive inward rectifier potassium channel 12 Inward rectifier potassium channel 2 Potassium channel subfamily K member 1 Potassium channel subfamily K member 9 Potassium channel subfamily K member Potassium channel subfamily K member Potassium channel subfamily K member Potassium inwardly rectifying channel subfamily J member 14 Potassium inwardly rectifying channel subfamily J member 4 Potassium two pore domain channel subfamily K member 10 Potassium two pore domain channel subfamily K member 12 Potassium two pore domain channel subfamily K member 13 Potassium two pore domain channel subfamily K member 15 Potassium two pore domain channel subfamily K member 16 Potassium two pore domain channel subfamily K member 18 Potassium two pore domain channel subfamily K member 2 Potassium two pore domain channel subfamily K member 4 Potassium two pore domain channel subfamily K member 5	A0A3Q1LQ50 A0A3Q1M4V6 A0A3Q1MT89 E1B9M4 E1BCI4 E1BEH1 E1BEH3 E1BGH7 E1BIA3 E1BNW6 F1MLI5 F1MW24 G3N1D1 G3N1Q6 O19182 Q0P5A0 Q4TZY1 Q8HZT2	IRK1 KCNJ12 KCNJ14 KCNJ2 KCNJ4 KCNK1 KCNK10 KCNK12 KCNK13 KCNK15 KCNK16 KCNK17 KCNK18 KCNK2 KCNK3 KCNK4 KCNK5 KCNK7 KCNK9	Bos taurus (cattle)
IRS-mediated signalling	Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform phosphatidylinositol-4,5-bisphosphate 3-kinase	F1MJE0 F1MYE0 F1MYM3 P23726 P23727 P32871	IRS1 IRS2 PIK3CA PIK3CB PIK3R1 PIK3R2	Bos taurus (cattle)
Laminin interactions	Integrin alpha-3 Integrin beta Integrin beta Integrin subunit alpha 6 Integrin subunit alpha 7 Laminin subunit alpha 4 Multiple EGF like domains 6 NID1 protein	A0A140T8D2 A0A3Q1M8K4 A0A3Q1MJT5 A0A3Q1MRM3 A0A3Q1N9E9 A6QNS6 E1BGA0 F1MMS9	ITGA3 ITGA6 ITGA7 ITGB1 ITGB4 LAMA4 MEGF6 NID1	Bos taurus (cattle)
Elevation of cytosolic Ca2+ levels	Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor P2X purinoceptor 4 P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor Short transient receptor potential channel 6 Transient receptor potential cation channel subfamily C member 3 Transient receptor potential cation channel subfamily C member 7	A0A3Q1LTG6 A0A3Q1M4W2 A0A3Q1N7P8 E1B742 E1BIH1 E1BIP1 E1BKE7 F1MUF3 F1MVZ6 F1MX21 F1N7A9 Q5E9U1 Q9MYW0	ITPR1 ITPR2 ITPR3 P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 TRP6 TRPC3 TRPC6 TRPC7	Bos taurus (cattle)
Phase 1 - inactivation of fast Na+ channels	Kv channel-interacting protein 4 Potassium voltage-gated channel interacting protein 1 Potassium voltage-gated channel interacting protein 2 Potassium voltage-gated channel interacting protein 3 Potassium voltage-gated channel subfamily D member 1 Potassium voltage-gated channel subfamily D member 2 Potassium voltage-gated channel subfamily D member 3	A0A3Q1LV43 A0A3Q1M5I5 A0A3Q1M784 F1MVI5 F1MY95 Q2KI69 Q52PG9	KCND1 KCND2 KCND3 KCNIP1 KCNIP2 KCNIP3 KCNIP4	Bos taurus (cattle)
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	Potassium channel subfamily K member 1 Potassium channel subfamily K member	E1B9M4 Q0P5A0	KCNK1 KCNK7	Bos taurus (cattle)
TWIK-related alkaline pH activated K+ channel (TALK)	Potassium channel subfamily K member Potassium two pore domain channel subfamily K member 16	E1BEH1 Q8HZT2	KCNK16 KCNK17	Bos taurus (cattle)
Ca activated K+ channels	Calcium-activated potassium channel subunit alpha-1 Calcium-activated potassium channel subunit beta-1 Calcium-activated potassium channel subunit beta Calcium-activated potassium channel subunit beta Potassium calcium-activated channel subfamily N member 1 Potassium calcium-activated channel subfamily N member 2 Potassium calcium-activated channel subfamily N member 3	E1BCE5 E1BGY2 E1BHB0 F1N467 Q1RMW7 Q28067 Q28204	KCNMA KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KCNN1 KCNN2 KCNN3	Bos taurus (cattle)
TFAP2 (AP-2) family regulates transcription of cell cycle factors	Myc proto-oncogene protein Transcription factor AP-2 gamma [histone H3]-trimethyl-L-lysine(4) demethylase	F1MUR2 Q0VC14 Q2HJ27	KDM5B MYC TFAP2C	Bos taurus (cattle)
VEGFR2 mediated cell proliferation	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma 3-phosphoinositide-dependent protein kinase 1 GTPase NRas Protein kinase C beta type Protein kinase C delta type Protein kinase C RAS p21 protein activator 1 Sphingosine kinase 1 Tyrosine-protein kinase Vascular endothelial growth factor A Vascular endothelial growth factor receptor 2 small monomeric GTPase	A0A3Q1MRR6 A0A3Q1MSP9 A5D7R9 E1BIM8 E1BMX0 F1MQJ7 F1MWF1 F1MXZ6 F1MYF9 F1N7N8 P05126 P15691	KDR KRAS NRAS PDPK1 PLCG1 PRKCB PRKCB1 PRKCD PRKCZ RASA1 SPHK1 SRC VEGF VEGFA	Bos taurus (cattle)
Regulation of cholesterol biosynthesis by SREBP (SREBF)	GTP-binding nuclear protein Ran Karyopherin subunit beta 1 MBTPS1 protein Membrane-bound transcription factor site-2 protease Sterol regulatory element-binding protein 1 Sterol regulatory element-binding protein 2 Sterol regulatory element-binding protein cleavage-activating protein	A0A3Q1M285 E1BFV0 F1ML06 F1MQ33 Q08E55 Q0III2 Q3T054	KPNB1 MBTPS1 MBTPS2 RAN SCAP SREBF1 SREBF2	Bos taurus (cattle)
Receptor-type tyrosine-protein phosphatases	Leucine rich repeat containing 4B PPFIA binding protein 1 PPFIA binding protein 2 PTPRF interacting protein alpha 1 PTPRF interacting protein alpha 2 PTPRF interacting protein alpha 3 PTPRF interacting protein alpha 4 Receptor-type tyrosine-protein phosphatase F SLIT and NTRK like family member 1 SLIT and NTRK like family member 2 SLIT and NTRK like family member 3 SLIT and NTRK like family member 4 SLIT and NTRK like family member 5 SLIT and NTRK like family member 6 Tyrosine-protein kinase receptor Uncharacterized protein protein-tyrosine-phosphatase protein-tyrosine-phosphatase	A0A3Q1LQ22 A0A3Q1M422 A0A3Q1M5L6 A0A3Q1M5X2 A0A3Q1MBH3 A0A3Q1MZF8 A7MBJ4 E1B8X9 E1BFL8 E1BIA1 E1BPK8 F1MJJ9 F1MQQ8 F1MSM8 F1N513 F1N5L8 G3N2N1 G3N3T6	LOC101901895 LRRC4B NTRK3 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRS SLITRK1 SLITRK2 SLITRK3 SLITRK4 SLITRK5 SLITRK6	Bos taurus (cattle)
Lysosomal oligosaccharide catabolism	Alpha-mannosidase Beta-mannosidase Lysosomal alpha-mannosidase alpha-mannosidase	A0A3Q1MEZ5 A0A3S5ZPJ9 F1MWT0 Q29451	LOC528518 MAN2B1 MAN2C1 MANB MANBA	Bos taurus (cattle)	G00027MO G25577BM G28233ME G70323CJ G90333CG
Events associated with phagocytolytic activity of PMN cells	Lactoperoxidase MPO protein	A6QPT4 P80025	LPO MPO	Bos taurus (cattle)
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	alpha-1,2-Mannosidase alpha-1,2-Mannosidase alpha-1,2-Mannosidase	A0A3Q1MKX0 E1B7B0 E1BNG2	MAN1A1 MAN1A2 MAN1C1	Bos taurus (cattle)	G70323CJ

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