GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **501 - 525** of **557** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol	Organism
TP53 Regulates Transcription of Death Receptors and Ligands	Insulin-like growth factor-binding protein 3 receptor Insulin-like growth factor-binding protein 3	P20959 Q1JQE1	IGFBP3 TMEM219	Bos taurus (cattle)
TRAF6 mediated NF-kB activation	Advanced glycosylation end-product specific receptor Amyloid-beta A4 protein High mobility group protein B1 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator NF-kappa-B inhibitor alpha (Fragment) NF-kappa-B inhibitor-interacting Ras-like protein 2 NF-kappaB transcription factor p65 subunit NFKB inhibitor interacting Ras like 1 NFKB2 protein Nuclear factor NF-kappa-B p105 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta Protein S100-A12 Protein S100-B	A0A3Q1LUG2 A0A3Q1LZM4 A1XG22 A7MBB7 F1MKW9 F1N306 P02638 P10103 P79105 Q0IIB2 Q1JPF1 Q8WNW7 Q95KU9 Q95KV0 Q95KV1	AGER APP CAAF1 CHUK HMG1 HMGB1 IKBKB IKBKG IKKA NEMO NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 RELA S100A12 S100B bIkBa	Bos taurus (cattle)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen-activated protein kinase kinase kinase 1 TNF receptor-associated factor 6	E1B847 Q3SX05 Q3ZCC3	ECSIT MAP3K1 TRAF6	Bos taurus (cattle)
TRP channels	Mucolipin TRP cation channel 1 Mucolipin TRP cation channel 2 Mucolipin TRP cation channel 3 Short transient receptor potential channel 1 Short transient receptor potential channel 4 Short transient receptor potential channel 6 Transient receptor potential cation channel subfamily A member 1 Transient receptor potential cation channel subfamily C member 3 Transient receptor potential cation channel subfamily C member 4 associated protein Transient receptor potential cation channel subfamily C member 5 Transient receptor potential cation channel subfamily C member 7 Transient receptor potential cation channel subfamily M member 4 Transient receptor potential cation channel subfamily M member 5 Transient receptor potential cation channel subfamily M member 8 Transient receptor potential cation channel subfamily V member 1 Transient receptor potential cation channel subfamily V member 2 Transient receptor potential cation channel subfamily V member 3 Transient receptor potential cation channel subfamily V member 4 Transient receptor potential cation channel subfamily V member 5 Transient receptor potential cation channel subfamily V member 6 non-specific serine/threonine protein kinase	A0A3Q1LTG6 A0A3Q1M0Y5 A0A3Q1M4W2 A0A3S5ZPA3 E1B6Y9 E1BAN3 E1BCP0 E1BDG0 E1BGM0 E1BNI9 E1BNX9 E1BPC8 F1MPF0 F1MTE6 F1N232 G3MY82 G3N2S2 G5E522 P79100 Q5EA32 Q9MYW0	MCOLN1 MCOLN2 MCOLN3 TRP6 TRPA1 TRPC1 TRPC3 TRPC4 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM4 TRPM5 TRPM7 TRPM8 TRPV1 TRPV2 TRPV3 TRPV4 TRPV5 TRPV6	Bos taurus (cattle)
TWIK-related alkaline pH activated K+ channel (TALK)	Potassium channel subfamily K member Potassium two pore domain channel subfamily K member 16	E1BEH1 Q8HZT2	KCNK16 KCNK17	Bos taurus (cattle)
Tachykinin receptors bind tachykinins	Neuromedin-K receptor Protachykinin-1 Substance-K receptor Substance-P receptor Tachykinin-3	F1MIX5 F1N2X0 P01289 P05363 P08858	NKA NKNA NKNB TAC1 TAC2 TAC2R TAC3 TACR1 TACR2 TACR3	Bos taurus (cattle)
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	Potassium channel subfamily K member 1 Potassium channel subfamily K member	E1B9M4 Q0P5A0	KCNK1 KCNK7	Bos taurus (cattle)
Terminal pathway of complement	Clusterin Complement C5 Complement C7 Complement C8 alpha chain Complement component C8 beta chain Complement component C9	A0A3Q1LI40 F1MX87 F1MY85 F1N102 P17697 Q3MHN2	C5 C7 C8A C8B C9 CLU	Bos taurus (cattle)
The NLRP3 inflammasome	Heat shock protein HSP 90-beta NACHT, LRR and PYD domains-containing protein 3 P2X purinoceptor PYD and CARD domain containing Pannexin Proline-serine-threonine phosphatase interacting protein 1 Protein SGT1 homolog Thioredoxin-interacting protein Thioredoxin	A0A3Q1N8Q0 A6QLE5 A7Z054 D7R519 F1MQF6 F1MVZ6 O97680 Q2KIK0 Q76LV1	HSP90AB1 HSPC3 HSPCB NLRP3 P2RX7 PANX PANX1 PSTPIP1 PYCARD SUGT1 TXN TXNIP	Bos taurus (cattle)
The activation of arylsulfatases	ARSB protein ARSE protein Arylsulfatase A Arylsulfatase G Arylsulfatase K Arylsulfatase family member H Arylsulfatase family member I Formylglycine-generating enzyme Inactive C-alpha-formylglycine-generating enzyme 2 Steroid sulfatase	A0A3Q1LZ44 A5D7J7 A6QLZ3 E1BIN3 F1N665 G3N2T7 Q08DD1 Q0P5L5 Q148F3 Q58CP2	ARSA ARSB ARSE ARSG ARSH ARSI ARSK ARSL STS SUMF1 SUMF2	Bos taurus (cattle)
The canonical retinoid cycle in rods (twilight vision)	Cytochrome P450 family 4 subfamily V member 2 Cytosolic fatty-acid binding proteins domain-containing protein Dehydrogenase/reductase SDR family member 9 Hydroxysteroid (17-beta) dehydrogenase 6 Lecithin retinol acyltransferase Microsomal NAD+-dependent retinol dehydrogenase 4 Myosin VIIA Plasma retinol-binding protein Receptor for retinol uptake STRA6 Retinal-specific phospholipid-transporting ATPase ABCA4 Retinaldehyde-binding protein 1 Retinol binding protein 1 Retinol binding protein 3 Retinol dehydrogenase 10 Retinol dehydrogenase 11 Retinol dehydrogenase 12 Retinol dehydrogenase 5 Rhodopsin Short-chain dehydrogenase/reductase family 9C member 7 Transthyretin	A0A3Q1LG56 A0A3Q1LU75 A0A3Q1MJ64 A0A3Q1MSW9 A0A452DJ95 A4IFM3 E1BM93 F1MD39 F1MG20 F1MLW4 F1MWM0 F1N3Z7 F6RLW9 O46375 P02699 P10123 Q0V8D0 Q27979 Q8HYR6 Q8HZT6	ABCA4 ABCR CRALBP CYP4V2 DHRS9 HSD17B6 LOC101906939 LRAT MYO7A RBP1 RBP3 RBP4 RDH1 RDH10 RDH11 RDH12 RDH16 RDH5 RDHS RHO RLBP1 SDR9C7 SDRO STRA6 TTR	Bos taurus (cattle)
The retinoid cycle in cones (daylight vision)	Dehydrogenase/reductase 3 Long-wave-sensitive opsin 1 Retinaldehyde-binding protein 1 Retinol binding protein 3 Short-wave-sensitive opsin 1	F1MLW4 F1N334 P10123 P51490 Q9BGI7	BCP CRALBP DHRS3 OPN1LW OPN1SW RBP3 RCP RLBP1	Bos taurus (cattle)
The role of GTSE1 in G2/M progression after G2 checkpoint	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cellular tumor antigen p53 Cyclin-dependent kinase 1 G2 and S-phase expressed 1 G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B2 Microtubule-associated protein RP/EB family member 1 Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta Serine/threonine-protein kinase PLK1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A140T859 A0A452DI44 A0A452DIY4 A7MBA2 E1BD83 F1MBI1 F1MLV1 F1MWE0 F1MXE4 F1MYH8 F1N6Z0 F6Q0H8 G5E589 P0CG53 P0CH28 P33672 P48734 P56701 P62194 P62992 P63048 P67939 Q17QP9 Q1LZG6 Q2KI42 Q2KJ25 Q2KJ46 Q2KJE7 Q2TA25 Q2YDE4 Q32KL2 Q3MHN0 Q3SX30 Q3SZ19 Q3SZC2 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3ZBD0 Q3ZBD9 Q3ZBG0 Q3ZCK9 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0	CCNB1 CCNB2 CDC2 CDK1 CDKN1 GTSE1 MAPRE1 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A SUG1 TP53 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Bos taurus (cattle)
Thromboxane signalling through TP receptor	Angio-associated migratory cell protein G protein subunit alpha 13 G protein subunit beta 3 G protein subunit gamma 13 GNB4 protein Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-14 Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit beta-5 Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Thromboxane A2 receptor	A0A3Q1NGS8 A0A3S5ZPL0 A4IFL6 A5PKD6 E1B8Q3 E1BA29 F1MYW8 F1N2V3 G5E6P3 P02698 P11017 P30671 P38408 P38409 P50154 P62871 P63212 P63214 P63217 Q28024 Q3SZ98 Q3SZK1 Q5E9F0 Q95125	AAMP GNA11 GNA13 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT12 GNGT2 GNGT3 GNGT5 GNGT7 GNGT8 TBXA2R	Bos taurus (cattle)
Thyroxine biosynthesis	Glycoprotein hormones alpha chain Iodotyrosine deiodinase 1 NAD(P)H oxidase (H2O2-forming) NAD(P)H oxidase (H2O2-forming) Solute carrier family 5 member 5 Thyroid peroxidase Thyrotropin subunit beta	A0A3Q1M790 A0A3S5ZPC4 E1BMK1 E1BMS3 F1MT46 P01217 P01223	CGA DUOX1 DUOX2 IYD SLC5A5 TPO TSHB	Bos taurus (cattle)
Tie2 Signaling	Angiopoietin-1 receptor Angiopoietin-1 Angiopoietin-2 Angiopoietin-like protein 4 Docking protein 2 GTPase NRas Growth factor receptor bound protein 14 Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-4,5-bisphosphate 3-kinase small monomeric GTPase	A5D7R9 A7MBB8 B2Z4B2 E1BMX0 F1MBA2 F1MYM3 F1N339 F1N7C3 O18920 O77802 P23726 P23727 P32871 Q06807 Q0IIE2 Q1RMW5 Q3T0F9	ANG1 ANG2 ANGPT1 ANGPT2 ANGPT4 ANGPTL4 DOK2 GRB14 GRB2 GRB7 KRAS NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PTPN11 SHC1 SOS1 TEK TIE-2 TIE2	Bos taurus (cattle)
Tight junction interactions	Junctional adhesion molecule A Par-3 family cell polarity regulator Par-6 family cell polarity regulator alpha Par-6 family cell polarity regulator beta Par-6 family cell polarity regulator gamma Protein kinase C	A0A3Q1LS90 A0A3Q1M590 A0A3Q1MIH4 F1MQ96 F6RHP0 Q9XT56	F11R JAM1 PARD3 PARD6A PARD6B PARD6G PRKCI	Bos taurus (cattle)
Toll Like Receptor 10 (TLR10) Cascade	Toll-like receptor 10	Q6GV17	TLR10	Bos taurus (cattle)
Toll Like Receptor 4 (TLR4) Cascade	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Bactericidal permeability-increasing protein CD180 molecule Dynamin-1 Integrin beta-2 Integrin subunit alpha M Lipopolysaccharide-binding protein Lymphocyte antigen 86 Lymphocyte antigen 96 Monocyte differentiation antigen CD14 TIR domain-containing adapter molecule 2 Toll-like receptor 4 Tyrosine-protein phosphatase non-receptor type dynamin GTPase	A0A3Q1MIC9 A0A3Q1MMD9 A0A3Q1MZF3 A6QNL0 C4T7Z1 E1BJR7 F1MFI2 F1MNN7 G3MYD9 P17453 P32592 Q08DF4 Q2LGB7 Q6WCD5	BPI CD14 CD18 CD180 DNM1 DNM3 ITGAM ITGB2 LBP LY86 LY96 MD-2 PLCG2 PTPN4 TICAM2 TLR4 TRAM	Bos taurus (cattle)
Toll Like Receptor 7/8 (TLR7/8) Cascade	Toll like receptor 7	A0A3Q1MK24	TLR7	Bos taurus (cattle)
Toll Like Receptor 9 (TLR9) Cascade	Early endosome antigen 1 Phosphatidylinositol 3-kinase catalytic subunit type 3 Toll-like receptor 9 non-specific serine/threonine protein kinase	A0A3Q1LQK4 A0A3Q1M5J6 A5H631 A6QLW1	EEA1 PIK3C3 PIK3R4 TLR9	Bos taurus (cattle)
Trafficking and processing of endosomal TLR	Cathepsin B Cathepsin K Cathepsin S Endoplasmin Legumain Procathepsin L Protein canopy homolog 3 Toll like receptor 3 Toll like receptor 7 Toll-like receptor 9 Unc-93 homolog B1, TLR signaling regulator	A0A140T8D4 A0A3Q1MK24 A0A3S5ZPK8 A5H631 E1BBH4 P07688 P25326 P25975 Q0P5N1 Q5E968 Q95M18	CNPY3 CTSB CTSK CTSL CTSL1 CTSS GRP94 HSP90B1 HSPC4 LGMN TLR3 TLR7 TLR9 TRA1 UNC93B1	Bos taurus (cattle)
Transcriptional activation of mitochondrial biogenesis	Cytochrome c GA binding protein transcription factor subunit alpha GA-binding protein subunit beta-1 Glutamate dehydrogenase 1, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial NAD-dependent protein deacetylase NAD-dependent protein deacylase sirtuin-5, mitochondrial NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Propionate--CoA ligase Superoxide dismutase [Mn], mitochondrial	A0A140T871 A0A3Q1M4F8 A0A3Q1MB37 E1BHL1 G5E521 P62894 Q04467 Q0VC98 Q1RMI3 Q3ZBQ0	ACSS2 CYC CYCS GABPA GABPB1 GABPB2 GLUD1 IDH2 SIRT3 SIRT4 SIRT5 SOD2	Bos taurus (cattle)
Transcriptional and post-translational regulation of MITF-M expression and activity	Adenosine 5'-monophosphoramidase HINT1 Adenosine 5'-monophosphoramidase HINT1 Adenosine 5'-monophosphoramidase HINT1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 Arginine--tRNA ligase, cytoplasmic Aspartate--tRNA ligase, cytoplasmic Eukaryotic translation elongation factor 1 epsilon 1 Exportin 1 Glutamine--tRNA ligase Glutamyl-prolyl-tRNA synthetase 1 Glycogen synthase kinase-3 beta Kit ligand Lysine--tRNA ligase Mast/stem cell growth factor receptor Melanocyte inducing transcription factor Methionine--tRNA ligase, cytoplasmic Mitogen-activated protein kinase 1 Mitogen-activated protein kinase Protein Wnt Ribosomal protein S6 kinase histone acetyltransferase isoleucine--tRNA ligase leucine--tRNA ligase	A0A3Q1LLF2 A0A3Q1LTW2 A0A3Q1LXT8 A0A3Q1MKP6 A0A3Q1MKR2 A0A3Q1MLN6 A0A3Q1MQJ9 A0A3Q1NC15 A0A3S5ZPT9 A0A452DHX3 A0A452DIE9 A7MBC5 A7YW98 E1B8P9 E1BE98 F1MD32 F1MIC3 F1MMK8 P46196 Q0II26 Q28132 Q3MHH4 Q3SZ15	AIMP2 CREBBP DARS1 EEF1E1 EPRS1 ERK2 GSK3B HINT1 IARS IARS1 JTV1 KARS1 KIT KITLG LARS1 MAPK1 MAPK3 MARS1 MITF PRKM1 QARS QARS1 RARS RARS1 RPS6KA1 SCF WNT3A XPO1	Bos taurus (cattle)
Transcriptional regulation by RUNX2	Core-binding factor subunit beta Cyclin-dependent kinase 1 Cyclin-dependent kinase 4 G1/S-specific cyclin-D1 G2/mitotic-specific cyclin-B1 Protein phosphatase, Mg2+/Mn2+ dependent 1D Runt-related transcription factor Transcription factor SOX-9	A0A3Q1MKY5 A0A3Q1MN22 A0A452DIV3 E1B9S8 E1BD03 P48734 Q1LZG6 Q32KY4	CBFB CCNB1 CCND1 CDC2 CDK1 CDK4 CDKN1 PPM1D RUNX2 SOX9	Bos taurus (cattle)

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