GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **26 - 50** of **268** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
TWIK-related alkaline pH activated K+ channel (TALK)	Potassium two pore domain channel subfamily K member 16 Potassium two pore domain channel subfamily K member 17	A0A8I3NSP8 A0A8I3NUY1	KCNK16 KCNK17	Canis familiaris (dog)
TRP channels	Mucolipin TRP cation channel 1 Mucolipin TRP cation channel 2 Mucolipin TRP cation channel 3 Short transient receptor potential channel 1 Transient receptor ion channel domain-containing protein Transient receptor potential cation channel subfamily A member 1 Transient receptor potential cation channel subfamily C member 3 Transient receptor potential cation channel subfamily C member 4 associated protein Transient receptor potential cation channel subfamily C member 4 Transient receptor potential cation channel subfamily C member 5 Transient receptor potential cation channel subfamily C member 7 Transient receptor potential cation channel subfamily M member 1 Transient receptor potential cation channel subfamily M member 2 Transient receptor potential cation channel subfamily M member 3 Transient receptor potential cation channel subfamily M member 4 Transient receptor potential cation channel subfamily M member 5 Transient receptor potential cation channel subfamily M member 7 Transient receptor potential cation channel subfamily M member 8 Transient receptor potential cation channel subfamily V member 1 Transient receptor potential cation channel subfamily V member 1 Transient receptor potential cation channel subfamily V member 2 Transient receptor potential cation channel subfamily V member 3 Transient receptor potential cation channel subfamily V member 4 Transient receptor potential cation channel subfamily V member 5 Transient receptor potential cation channel subfamily V member 6 non-specific serine/threonine protein kinase	A0A8I3MEX0 A0A8I3MHU7 A0A8I3MK71 A0A8I3MP37 A0A8I3MYU1 A0A8I3N8J6 A0A8I3NMH9 A0A8I3NUS5 A0A8I3NVQ7 A0A8I3P285 A0A8I3P620 A0A8I3P6G6 A0A8I3PAV3 A0A8I3PBJ8 A0A8I3PHN0 A0A8I3PPS5 A0A8I3PRR6 A0A8I3PSS9 A0A8I3Q1Q7 A0A8I3Q281 A0A8I3Q7K0 A0A8I3RWJ9 A0A8I3S1Y6 A0A8I3S366 A0A8I3S6T7 Q697L1	MCOLN1 MCOLN2 MCOLN3 TRPA1 TRPC1 TRPC3 TRPC4 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPV1 TRPV2 TRPV3 TRPV4 TRPV5 TRPV6	Canis familiaris (dog)
TNFs bind their physiological receptors	CD27 molecule CD70 molecule EDAR associated via death domain Ectodysplasin A receptor Ectodysplasin A LIGHT Lymphotoxin-alpha Migration and invasion inhibitory protein TNF family profile domain-containing protein TNF receptor superfamily member 14 TNF receptor superfamily member 17 TNF receptor superfamily member 18 TNF receptor superfamily member 1B TNF receptor superfamily member 6b TNF receptor superfamily member 9 TNF superfamily member 13 TNF superfamily member 13b TNF superfamily member 18 TNF superfamily member 4 TNF superfamily member 8 TNFR-Cys domain-containing protein Tumor necrosis factor ligand superfamily member Tumor necrosis factor receptor superfamily member 11B Uncharacterized protein Uncharacterized protein	A0A0U5JAK9 A0A8I3MEA7 A0A8I3MKG7 A0A8I3MM10 A0A8I3MPQ0 A0A8I3N568 A0A8I3NB07 A0A8I3NFC1 A0A8I3NGJ3 A0A8I3NJU2 A0A8I3NZX5 A0A8I3P405 A0A8I3PKB9 A0A8I3PLK9 A0A8I3PMM9 A0A8I3Q3L1 A0A8I3Q7M4 A0A8I3QDG0 A0A8I3S9F2 E2R8I1 E2RP79 J9JHM5 J9P753 Q58P77 Q5WR07	CD27 CD70 EDA EDAR EDARADD LTA MIIP TNFB TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF6B TNFRSF9 TNFSF1 TNFSF11 TNFSF13 TNFSF13B TNFSF14 TNFSF18 TNFSF4 TNFSF8 TNLG1D TNLG2A TNLG2B TNLG3A TNLG7A	Canis familiaris (dog)
TNFR2 non-canonical NF-kB pathway	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 CD40 ligand LIGHT Lymphotoxin beta receptor Lymphotoxin-alpha Lymphotoxin-beta Mitogen-activated protein kinase kinase kinase 14 Proteasome 20S subunit alpha 3 Proteasome 26S subunit, ATPase 1 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 10 Proteasome 26S subunit, non-ATPase 12 Proteasome 26S subunit, non-ATPase 14 Proteasome 26S subunit, non-ATPase 3 Proteasome 26S subunit, non-ATPase 7 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit beta type-8 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta TNF receptor superfamily member 11a TNF receptor superfamily member 12A TNF receptor superfamily member 13C TNF receptor superfamily member 1B TNF receptor-associated factor TNF receptor-associated factor TNF superfamily member 13b Tumor necrosis factor (ligand) superfamily, member 12 Tumor necrosis factor ligand superfamily member Tumor necrosis factor receptor superfamily member 5 Tumor necrosis factor Uncharacterized protein Uncharacterized protein	A0A8I3MDM0 A0A8I3MEA7 A0A8I3MES0 A0A8I3MNI0 A0A8I3MQC7 A0A8I3MR89 A0A8I3MU16 A0A8I3MUE2 A0A8I3MWN3 A0A8I3N0P1 A0A8I3N165 A0A8I3N3S4 A0A8I3N5F1 A0A8I3N952 A0A8I3N9G3 A0A8I3NGJ3 A0A8I3NH42 A0A8I3NLQ1 A0A8I3NN65 A0A8I3NNJ9 A0A8I3NP66 A0A8I3NPX1 A0A8I3NRP3 A0A8I3NUC6 A0A8I3NUK8 A0A8I3NW81 A0A8I3NXK9 A0A8I3P6H0 A0A8I3P6M2 A0A8I3PB85 A0A8I3PBB2 A0A8I3PCE5 A0A8I3PCT4 A0A8I3PDR8 A0A8I3PF55 A0A8I3PF76 A0A8I3PJW0 A0A8I3PKH4 A0A8I3PMA2 A0A8I3PTD2 A0A8I3PZM4 A0A8I3PZT2 A0A8I3QV78 A0A8I3RR83 A0A8I3RRR7 A0A8I3RT39 A0A8I3RXV3 A0A8I3RZF7 A0A8I3RZP6 A0A8I3S1Z6 A0A8I3S6C6 A0A8I3S6Q5 A1E2V0 J9JHM5 J9P2Z1 J9P753 O97626 P51742 Q5W412 Q5W416 Q5WR07	BIRC2 BIRC3 CD40 CD40L CD40LG LOC100686569 LOC100687259 LOC610717 LTA LTB LTBR MAP3K14 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 TNF TNFA TNFB TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF1B TNFSF1 TNFSF11 TNFSF12 TNFSF13B TNFSF14 TNFSF2 TNFSF5 TNLG1C TNLG1D TNLG7A TRAF2 TRAF3	Canis familiaris (dog)
TNFR1-mediated ceramide production	Neutral sphingomyelinase activation associated factor Small ribosomal subunit protein RACK1 TNFR-Cys domain-containing protein Tumor necrosis factor sphingomyelin phosphodiesterase sphingomyelin phosphodiesterase	A0A8I3NH12 A0A8I3NK36 A0A8I3Q3L1 A0A8I3QLC7 A0A8I3RSQ2 P51742	NSMAF RACK1 SMPD2 SMPD3 TNF TNFA TNFRSF1A TNFSF2	Canis familiaris (dog)
TNFR1-induced proapoptotic signaling	Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 E3 ubiquitin-protein ligase XIAP Inhibitor of nuclear factor kappa B kinase subunit epsilon RBR-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RanBP-type and C3HC4-type zinc finger-containing protein 1 Receptor interacting serine/threonine kinase 1 Spermatogenesis associated 2 TANK binding kinase 1 TNF receptor-associated factor TNFR-Cys domain-containing protein Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor Ubiquitin carboxyl-terminal hydrolase CYLD	A0A8I3MDM0 A0A8I3MQC7 A0A8I3MSL4 A0A8I3MYA4 A0A8I3NEJ2 A0A8I3NK16 A0A8I3NS04 A0A8I3P2P4 A0A8I3PS24 A0A8I3Q155 A0A8I3Q3L1 A0A8I3S2L7 A1E2V0 P51742 Q38IV1	BIRC2 BIRC3 BIRC4 CYLD IKBKE IRF9 MIB2 RBCK1 RIPK1 SPATA2 TBK1 TNF TNFA TNFRSF1A TNFSF2 TRADD TRAF2 XIAP	Canis familiaris (dog)
TNFR1-induced NF-kappa-B signaling pathway	Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 E3 ubiquitin-protein ligase XIAP IkappaB kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Optineurin RBR-type E3 ubiquitin transferase RanBP-type and C3HC4-type zinc finger-containing protein 1 Receptor interacting serine/threonine kinase 1 Small ribosomal subunit protein RACK1 Spermatogenesis associated 2 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TNF receptor-associated factor TNFR-Cys domain-containing protein Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Uncharacterized protein ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A8I3MA34 A0A8I3MDM0 A0A8I3MQC7 A0A8I3MSL4 A0A8I3MYA4 A0A8I3N1V1 A0A8I3N4F2 A0A8I3N7L6 A0A8I3NEJ2 A0A8I3NMB6 A0A8I3NP69 A0A8I3P2P4 A0A8I3P499 A0A8I3P4Z1 A0A8I3PLL0 A0A8I3PS24 A0A8I3PWL6 A0A8I3Q3L1 A0A8I3RSQ2 A0A8I3RUY7 A0A8I3RZA9 A0A8I3S2L7 A0A8I3S792 A0A8I3S794 A1E2V0 P51742 Q38IV1	BIRC2 BIRC3 BIRC4 CHUK CYLD IKBKB IKBKG IRF9 MAP3K7 OPTN OTUD1 OTUD7B RACK1 RBCK1 RIPK1 SPATA2 TAB1 TAB2 TAB3 TNF TNFA TNFAIP3 TNFRSF1A TNFSF2 TRADD TRAF2 USP2 USP21 USP4 XIAP	Canis familiaris (dog)
TNF signaling	ADAM metallopeptidase domain 17 Receptor interacting serine/threonine kinase 1 TNF receptor-associated factor TNFR-Cys domain-containing protein Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor	A0A8I3MQC7 A0A8I3NEJ2 A0A8I3PPY4 A0A8I3Q3L1 A0A8I3S2L7 P51742	ADAM17 RIPK1 TNF TNFA TNFRSF1A TNFSF2 TRADD TRAF2	Canis familiaris (dog)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 CD40 ligand LIGHT Lymphotoxin beta receptor Lymphotoxin-alpha Lymphotoxin-beta Mitogen-activated protein kinase kinase kinase 14 TNF receptor superfamily member 11a TNF receptor superfamily member 12A TNF receptor superfamily member 13C TNF receptor-associated factor TNF receptor-associated factor TNF superfamily member 13b Tumor necrosis factor (ligand) superfamily, member 12 Tumor necrosis factor ligand superfamily member Tumor necrosis factor receptor superfamily member 5	A0A8I3MDM0 A0A8I3MES0 A0A8I3MQC7 A0A8I3MWN3 A0A8I3NGJ3 A0A8I3NLQ1 A0A8I3NRP3 A0A8I3P6H0 A0A8I3PTD2 A0A8I3PZM4 A0A8I3RR83 A1E2V0 J9JHM5 J9P2Z1 J9P753 O97626 Q5WR07	BIRC2 BIRC3 CD40 CD40L CD40LG LTA LTB LTBR MAP3K14 TNFB TNFRSF11A TNFRSF12A TNFRSF13C TNFSF1 TNFSF11 TNFSF12 TNFSF13B TNFSF14 TNFSF5 TNLG1C TNLG1D TNLG7A TRAF2 TRAF3	Canis familiaris (dog)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Dipeptidyl peptidase 4 Free fatty acid receptor 1 Free fatty acid receptor 4 G protein subunit alpha transducin 3 G protein subunit gamma 13 G protein-coupled receptor 119 Gastrin-releasing peptide Glucagon Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Leptin	A0A8I3MH22 A0A8I3P5C5 A0A8I3PJF2 A0A8I3PQY2 A0A8I3Q958 A0A8I3QXE0 A0A8I3QZL6 A0A8I3RQW9 A0A8I3S964 P62872 P79147	DPP4 FFAR1 FFAR4 GCG GNAT3 GNB1 GNB3 GNG13 GPR119 GRP LEP	Canis familiaris (dog)	G58161NS
Synthesis, secretion, and deacylation of Ghrelin	1-alkyl-2-acetylglycerophosphocholine esterase Appetite-regulating hormone Carboxylic ester hydrolase Glucagon Insulin-like growth factor I Insulin Leptin Membrane bound O-acyltransferase domain containing 4 Neuroendocrine convertase 1 Signal peptidase complex catalytic subunit SEC11A Signal peptidase complex subunit 1 Signal peptidase complex subunit 2 Signal peptidase complex subunit 3 Somatotropin Uncharacterized protein	A0A8I3NP76 A0A8I3PBA0 A0A8I3PYH6 A0A8I3QXE0 A0A8I3RR59 A0A8I3RXD7 A0A8I3S964 P01321 P33711 P33712 P61008 P67811 P83362 Q28250 Q9BEF8	BCHE GCG GH GH1 GHRL IGF1 IGFIA INS LEP MBOAT4 MTLRP PCSK1 PLA2G7 SEC11A SEC11L1 SPC12 SPC18 SPC22 SPC25 SPCS1 SPCS2 SPCS3	Canis familiaris (dog)	G58161NS
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Acyl-coenzyme A oxidase Bile acid-CoA Bile salt export pump Cytochrome P450 family 27 subfamily A member 1 Cytochrome P450 family 7 subfamily A member 1 Cytochrome P450 family 7 subfamily B member 1 Cytochrome P450 family 8 subfamily B member 1 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Hydroxysteroid 17-beta dehydrogenase 4 NADP-dependent oxidoreductase domain-containing protein Nuclear receptor coactivator Nuclear receptor coactivator Nuclear receptor subfamily 1 group H member 4 Prostacyclin synthase Retinoic acid receptor RXR Sterol carrier protein 2 long-chain-fatty-acid--CoA ligase long-chain-fatty-acid--CoA ligase palmitoyl-CoA hydrolase	A0A8I3MAI7 A0A8I3N1E1 A0A8I3N2S7 A0A8I3N3X9 A0A8I3NIH7 A0A8I3NZF5 A0A8I3P4G5 A0A8I3P7P8 A0A8I3PDX5 A0A8I3PFY5 A0A8I3PJM8 A0A8I3PRC4 A0A8I3PYI4 A0A8I3RWQ9 A0A8I3RZP4 A0A8I3S339 A0A8I3S6P6 A0A8I3SAZ3 B8K1W2	ACOT8 ACOX2 Abcb11e BAAT BSEP CYP27A1 CYP7A1 CYP7B1 CYP8B1 HSD17B4 HSD3B7 LOC119874618 NCOA1 NCOA2 NR1H4 PTGIS RXRA SCP2 SLC27A2 SLC27A5	Canis familiaris (dog)
Synthesis of bile acids and bile salts	Cytochrome P450 family 7 subfamily A member 1 Cytochrome P450 family 7 subfamily B member 1 Nuclear receptor coactivator Nuclear receptor coactivator Nuclear receptor subfamily 1 group H member 4 Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Retinoic acid receptor RXR	A0A8I3N2S7 A0A8I3NA48 A0A8I3NIH7 A0A8I3NPK5 A0A8I3NS93 A0A8I3P033 A0A8I3P4G5 A0A8I3PNT4 A0A8I3PRC4 A0A8I3PYI4 A0A8I3S236 A0A8I3S5H8 A0A8I3SAZ3	CYP7A1 CYP7B1 NCOA1 NCOA2 NR1H4 OSBP OSBPL1A OSBPL2 OSBPL3 OSBPL6 OSBPL7 OSBPL9 RXRA	Canis familiaris (dog)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Cytochrome P450 family 8 subfamily B member 1 Prostacyclin synthase Prostaglandin E synthase 2 Prostaglandin E synthase Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Prostaglandin-H2 D-isomerase Thromboxane-A synthase carbonyl reductase (NADPH) glutathione transferase	A0A8I3MUQ9 A0A8I3PFY5 A0A8I3PJM8 A0A8I3PV18 A0A8I3Q8L4 A0SYQ0 B4YY03 E5RQH2 Q8HZR1 Q8SPQ9	CBR1 COX-2 COX1 CYP8B1 H-PGDS HPGDS PGES PTGDS PTGES PTGES2 PTGIS PTGS1 PTGS2 TBXAS1	Canis familiaris (dog)
Synthesis of Leukotrienes (LT) and Eoxins (EX)	Arachidonate 5-lipoxygenase-activating protein Arachidonate 5-lipoxygenase Cytochrome P450 4A37 Cytochrome P450 4A39 Cytochrome P450 family 4 subfamily B member 1 Cytochrome P450 family 4 subfamily F member 22 Dipeptidase 3 Dipeptidase Dipeptidase Glutathione hydrolase Leukotriene A(4) hydrolase Leukotriene C4 synthase Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Polyunsaturated fatty acid lipoxygenase ALOX15 Uncharacterized protein Uncharacterized protein	A0A8I3MKG9 A0A8I3MWD6 A0A8I3N1I8 A0A8I3NBG0 A0A8I3NUL1 A0A8I3NW02 A0A8I3NZI5 A0A8I3P4E2 A0A8I3P5X5 A0A8I3PDD9 A0A8I3PHP8 A0A8I3PP24 A0A8I3RZ66 A0A8I3S2G2 A0A8I3SA30 Q2VHZ7 Q6UR05	ABCC1 ALOX15 ALOX5 ALOX5AP CYP4A11 CYP4A37 CYP4A39 CYP4B1 CYP4F22 DPEP1 DPEP2 DPEP3 GGT1 LOC119863926 LTA4H LTC4S MRP1	Canis familiaris (dog)
Synthesis of IP3 and IP4 in the cytosol	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase EF-hand domain-containing protein Inositol polyphosphate-5-phosphatase J Inositol-tetrakisphosphate 1-kinase Kinase Kinase Kinase Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphoinositide phospholipase C Phosphoinositide phospholipase C Phosphoinositide phospholipase C Phosphoinositide phospholipase C Phosphoinositide phospholipase C Phosphoinositide phospholipase C Phospholipase C delta 4 Phospholipase C zeta 1 Uncharacterized protein phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase phosphoinositide 5-phosphatase phosphoinositide 5-phosphatase phosphoinositide 5-phosphatase	A0A8I3MH68 A0A8I3MSQ7 A0A8I3MYA9 A0A8I3N810 A0A8I3NFE2 A0A8I3NWQ5 A0A8I3NY96 A0A8I3NZG2 A0A8I3PAP4 A0A8I3PAT0 A0A8I3PB87 A0A8I3PC05 A0A8I3PFD9 A0A8I3PLP7 A0A8I3PN52 A0A8I3PQK7 A0A8I3Q2Q7 A0A8I3Q4W3 A0A8I3Q7I7 A0A8I3Q9F2 A0A8I3QSE4 A0A8I3S2X3 A0A8I3S6D4 A0A8I3S7X1 A0A8I3SCI7 P60483	CALM2 INPP5B INPP5D INPP5J INPPL1 ITPK1 ITPKA ITPKB ITPKC MMAC1 OCRL PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCZ1 PLD4 PTEN SHIP2 SYNJ1	Canis familiaris (dog)
Synthesis of 5-eicosatetraenoic acids	Arachidonate 5-lipoxygenase-activating protein Arachidonate 5-lipoxygenase Leukotriene C4 synthase Paraoxonase 3 Paraoxonase Paraoxonase	A0A8I3MWD6 A0A8I3PAM3 A0A8I3PDD9 A0A8I3PDF6 A0A8I3PDS2 A0A8I3SA30	ALOX5 ALOX5AP LTC4S PON1 PON2 PON3	Canis familiaris (dog)
Synaptic adhesion-like molecules	Discs large MAGUK scaffold protein 3 Discs large MAGUK scaffold protein 4 Disks large homolog 1 Flotillin Flotillin Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Glutamate receptor Glutamate receptor Glutamate receptor Glutamate receptor Glutamate receptor Glutamate receptor Leucine rich repeat and fibronectin type III domain containing 1 Leucine rich repeat and fibronectin type III domain containing 2 Leucine rich repeat and fibronectin type III domain containing 4 Leucine-rich repeat and fibronectin type-III domain-containing protein 3 Receptor-type tyrosine-protein phosphatase F Reticulon protein-tyrosine-phosphatase	A0A8I3MHF6 A0A8I3MLF1 A0A8I3MYK4 A0A8I3N069 A0A8I3N2F7 A0A8I3N7W4 A0A8I3NEU9 A0A8I3NRD6 A0A8I3NUJ0 A0A8I3NVY0 A0A8I3NZA0 A0A8I3P9B8 A0A8I3PJ11 A0A8I3PXY0 A0A8I3QNS7 A0A8I3RRH4 A0A8I3RS83 A0A8I3S101 Q5R1P0 Q5R1P3	DLG1 DLG3 DLG4 FLOT1 FLOT2 GRIA1 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D LRFN1 LRFN2 LRFN3 LRFN4 NMDAR1 PTPRD PTPRF RTN3	Canis familiaris (dog)
Surfactant metabolism	ATP binding cassette subfamily A member 3 Adenosine receptor A2a Adhesion G protein-coupled receptor F5 Alpha-2A adrenergic receptor Alpha-2C adrenergic receptor C-type lectin domain-containing protein Coiled-coil domain containing 59 Colony stimulating factor 2 receptor subunit beta Cytoskeleton associated protein 4 Fibronectin type-III domain-containing protein GATA binding protein 6 LIM and cysteine rich domains 1 Napsin A aspartic peptidase P2Y purinoceptor 2 Palmitoyltransferase Pepsin A Pro-cathepsin H Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C SRCR domain-containing protein Sodium-dependent phosphate transport protein 2A Sodium-dependent phosphate transport protein 2B Transcription termination factor 1 Uncharacterized protein	A0A8I3MSD7 A0A8I3MZ62 A0A8I3NCW6 A0A8I3NFK5 A0A8I3NFY6 A0A8I3NHV8 A0A8I3NQ93 A0A8I3NR35 A0A8I3NUR4 A0A8I3NUT9 A0A8I3NWG1 A0A8I3NWJ3 A0A8I3NXR2 A0A8I3NZU4 A0A8I3P3J7 A0A8I3PBB4 A0A8I3PJM9 A0A8I3Q7S8 A0A8I3RTH9 A0A8I3RVV0 A0A8I3RW10 A0A8I3S9H9 P11617 Q9GMY6	ABCA3 ADGRF5 ADORA2A ADRA2A ADRA2C CCDC59 CKAP4 CSF2RA CSF2RB CTSH GATA6 LMCD1 LOC610540 NAPSA P2RY2 PGA PGNA RDC8 SFTPB SFTPC SFTPD SLC34A1 SLC34A2 TTF1 ZDHHC2	Canis familiaris (dog)
Stimuli-sensing channels	Acid sensing ion channel subunit 1 Acid sensing ion channel subunit 2 Acid sensing ion channel subunit 3 Acid sensing ion channel subunit family member 4 Acid sensing ion channel subunit family member 5 Amiloride-sensitive sodium channel subunit alpha Amiloride-sensitive sodium channel subunit beta Amiloride-sensitive sodium channel subunit gamma Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Aspartate beta-hydroxylase Barttin CLCNK type accessory subunit beta Bestrophin Bestrophin Bestrophin Bestrophin Calcium-activated chloride channel regulator 1 Chloride channel accessory 2 Chloride channel accessory 4 Chloride channel protein 1 Chloride channel protein 2 Chloride channel protein Chloride channel protein Chloride channel protein Chloride channel protein Chloride channel protein Chloride intracellular channel protein E3 ubiquitin-protein ligase EF-hand domain-containing protein HECT-type E3 ubiquitin transferase Osteoclastogenesis associated transmembrane protein 1 Protein tweety homolog Protein tweety homolog Protein tweety homolog RAF proto-oncogene serine/threonine-protein kinase Ryanodine receptor 1 Ryanodine receptor 2 Ryanodine receptor 3 Serine/threonine-protein kinase Sgk1 Serum/glucocorticoid regulated kinase family, member 3 Sodium channel epithelial 1 subunit delta Sodium leak channel, non-selective Solute carrier family 17 member 3 Solute carrier family 9 member B1 Solute carrier family 9 member B2 Solute carrier family 9 member C2 (putative) Sorcin Stomatin like 3 Stomatin Triadin Two pore segment channel 1 Two pore segment channel 2 Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Unc-79 homolog, NALCN channel complex subunit Unc-80 homolog, NALCN channel complex subunit peptidylprolyl isomerase	A0A8I3M9N6 A0A8I3MIG8 A0A8I3MK25 A0A8I3MKE6 A0A8I3MKT6 A0A8I3MMN5 A0A8I3MSQ7 A0A8I3MT21 A0A8I3MUX4 A0A8I3MXS3 A0A8I3N0C5 A0A8I3N0E7 A0A8I3N106 A0A8I3N6S0 A0A8I3N726 A0A8I3NAC3 A0A8I3NFB9 A0A8I3NH80 A0A8I3NHZ8 A0A8I3NKC4 A0A8I3NSX7 A0A8I3NUI9 A0A8I3NXW9 A0A8I3NYL1 A0A8I3P370 A0A8I3P4T9 A0A8I3P560 A0A8I3P659 A0A8I3P6A5 A0A8I3P7M3 A0A8I3P948 A0A8I3PAS7 A0A8I3PCD4 A0A8I3PDN2 A0A8I3PET1 A0A8I3PGN5 A0A8I3PJ01 A0A8I3PJ21 A0A8I3PJD4 A0A8I3PNF9 A0A8I3PP54 A0A8I3PRH5 A0A8I3PSM5 A0A8I3PV66 A0A8I3PY43 A0A8I3PZA0 A0A8I3Q0B9 A0A8I3Q0M9 A0A8I3Q2P4 A0A8I3Q383 A0A8I3Q4Q6 A0A8I3Q679 A0A8I3Q886 A0A8I3Q8P6 A0A8I3Q8R4 A0A8I3QA03 A0A8I3QXX9 A0A8I3QYD0 A0A8I3RQJ2 A0A8I3RSF1 A0A8I3RW06 A0A8I3RY81 A0A8I3RZ58 A0A8I3S651 A0A8I3SA78 P63050 Q9MZT1	ANO1 ANO2 ANO3 ANO4 ANO5 ANO6 ANO7 ANO8 ANO9 ASIC1 ASIC2 ASIC3 ASIC4 ASIC5 ASPH BEST1 BEST2 BEST3 BEST4 BSND CALM2 CLCA1 CLCA2 CLCA4 CLCN1 CLCN2 CLCN4 CLCN5 CLCN6 CLCN7 CLCNK CLCNKA CLIC2 LOC119880472 NALCN NEDD4L OSTM1 RAF1 RPS27A RYR1 RYR2 RYR3 SCNN1A SCNN1B SCNN1D SCNN1G SGK1 SGK3 SLC17A2 SLC9B1 SLC9B2 SLC9C2 SRI STOM STOML3 TPCN1 TPCN2 TRDN TTYH1 TTYH2 TTYH3 UBA52 UBB UBC UBCEP2 UNC79 UNC80 WWP1	Canis familiaris (dog)
Sphingolipid de novo biosynthesis	3-dehydrosphinganine reductase Broad substrate specificity ATP-binding cassette transporter ABCG2 Ceramide synthase 1 Ceramide synthase 2 Ceramide synthase 3 Ceramide synthase 4 Ceramide synthase 5 Ceramide synthase 6 Cytochrome b5 heme-binding domain-containing protein Delta 4-desaturase, sphingolipid 2 Fatty acid 2-hydroxylase Major facilitator superfamily domain containing 2B Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 ORM1-like protein ORM1-like protein ORM1-like protein SPNS lysolipid transporter 2, sphingosine-1-phosphate Serine palmitoyltransferase 1 Serine palmitoyltransferase long chain base subunit 2 Serine palmitoyltransferase long chain base subunit 3 Sphingolipid delta(4)-desaturase DES1 Sphingomyelin synthase 2 Sphingosine kinase 1 Sphingosine kinase 2 Sterile alpha motif domain containing 8 Uncharacterized protein Uncharacterized protein	A0A8I3MDB1 A0A8I3MDX2 A0A8I3MH69 A0A8I3MTG4 A0A8I3MVV0 A0A8I3MZT5 A0A8I3N0C8 A0A8I3N1I8 A0A8I3N6A8 A0A8I3N8H8 A0A8I3NCL9 A0A8I3NE51 A0A8I3NF48 A0A8I3P1Y0 A0A8I3P1Z6 A0A8I3P4B7 A0A8I3PAM7 A0A8I3PG24 A0A8I3PM33 A0A8I3PMG7 A0A8I3PQ53 A0A8I3Q2P7 A0A8I3S0D0 A0A8I3S194 A0A8I3S6X3 A0A8I3S790 B3RFJ1 Q6UR05	ABCC1 ABCG2 Abcg2 CERS1 CERS2 CERS3 CERS4 CERS5 CERS6 CYB5B DEGS1 DEGS2 FA2H KDSR MFSD2B MRP1 ORMDL1 ORMDL2 ORMDL3 SAMD8 SGMS1 SGMS2 SPHK1 SPHK2 SPNS2 SPTLC1 SPTLC2 SPTLC3 SPTSSA	Canis familiaris (dog)
Sodium/Calcium exchangers	EF-hand domain-containing protein Sodium/calcium exchanger 1 Solute carrier family 24 member 2 Solute carrier family 24 member 3 Solute carrier family 24 member 4 Solute carrier family 24 member 5 Solute carrier family 8 member A2 Solute carrier family 8 member A3 Solute carrier family 8 member B1 Sorcin	A0A8I3MSQ7 A0A8I3MTJ5 A0A8I3NPM6 A0A8I3NX53 A0A8I3PDR2 A0A8I3PJY1 A0A8I3Q687 A0A8I3RTF4 A0A8I3RY81 P23685	CALM2 NCX1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC8A1 SLC8A2 SLC8A3 SLC8B1 SRI	Canis familiaris (dog)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Cartilage intermediate layer protein Insulin-like growth factor I Insulin-like growth factor II Tyrosine-protein kinase receptor	A0A8I3NI15 A0A8I3RQ77 A0A8I3S512 P33712	CILP IGF1 IGF1R IGF2 IGFIA	Canis familiaris (dog)
Signaling by SCF-KIT	Chymase GRB2 associated binding protein 2 GRB2 related adaptor protein 2 GRB2 related adaptor protein GTPase HRas GTPase NRas Growth factor receptor bound protein 10 Growth factor receptor bound protein 2 Growth factor receptor bound protein 7 Kit ligand Mast/stem cell growth factor receptor Kit Matrix metalloproteinase-9 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 Protein kinase C Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Serine/threonine-protein kinase Chk1 Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Vav guanine nucleotide exchange factor 1 phosphatidylinositol-4,5-bisphosphate 3-kinase protein-tyrosine-phosphatase small monomeric GTPase	A0A5F4C2B1 A0A8I3MAK5 A0A8I3MKV4 A0A8I3ML64 A0A8I3MW46 A0A8I3N971 A0A8I3N974 A0A8I3N9M7 A0A8I3NA65 A0A8I3NAC6 A0A8I3NB92 A0A8I3NBK6 A0A8I3NBM3 A0A8I3NH46 A0A8I3NID0 A0A8I3NVH4 A0A8I3P3X1 A0A8I3P478 A0A8I3P519 A0A8I3P5U0 A0A8I3P6Q8 A0A8I3PMT9 A0A8I3PSA1 A0A8I3PSP7 A0A8I3PT69 A0A8I3PUN0 A0A8I3PUQ8 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3RV66 A0A8I3RVE7 A0A8I3S3D9 A0A8I3S3N2 A0A8I3SBF9 O97799 P21842 P62999 Q06220	CHEK1 CMA1 FER FES FYN GAB2 GRAP GRAP2 GRB10 GRB2 GRB7 HRAS JAK2 KIT KITLG KRAS LCK LOC100856339 LYN MGF MMP9 NRAS PIK3CA PIK3R1 PIK3R2 PRKCA PTPN11 PTPRU RAC1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B TEC VAV1 YES1	Canis familiaris (dog)
Signaling by ROBO receptors	Glypican-1 Slit guidance ligand 2 Slit guidance ligand 3	A0A8I3MRE2 A0A8I3NQC4 A0A8I3Q4U0	GPC1 SLIT2 SLIT3	Canis familiaris (dog)

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