GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **51 - 75** of **268** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Signaling by PDGF	Collagen type IV alpha 1 chain Collagen type IV alpha 2 chain Collagen type IV alpha 3 chain Collagen type IV alpha 4 chain Collagen type IV alpha 5 chain Collagen type IX alpha 1 chain Collagen type IX alpha 2 Collagen type IX alpha 3 chain Plasminogen Platelet-derived growth factor C Platelet-derived growth factor D Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Secreted phosphoprotein 1 Thrombospondin 1 Thrombospondin 2 Thrombospondin 3 Thrombospondin 4 furin protein-tyrosine-phosphatase t-plasminogen activator	A0A8I3MF27 A0A8I3MGR1 A0A8I3MW94 A0A8I3N1T9 A0A8I3N488 A0A8I3NAN8 A0A8I3NB75 A0A8I3NC04 A0A8I3NEF4 A0A8I3NEX5 A0A8I3NL86 A0A8I3NM06 A0A8I3NMW4 A0A8I3NXU0 A0A8I3P1W2 A0A8I3P613 A0A8I3P8B9 A0A8I3PDX7 A0A8I3PJI8 A0A8I3PPU8 A0A8I3S0U4 E2DP67 Q6Q7I7	COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL9A1 COL9A2 COL9A3 FURIN PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PLAT PLG PTPN12 SPP1 THBS1 THBS2 THBS3 THBS4	Canis familiaris (dog)
Signaling by Insulin receptor	Insulin Tyrosine-protein kinase receptor	A0A8I3PWD4 P01321	INS INSR	Canis familiaris (dog)
Signaling by BMP	Bone morphogenetic protein 10 Bone morphogenetic protein 2 Cerberus 1, DAN family BMP antagonist Chordin like 1 E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase E3 ubiquitin-protein ligase Follistatin-related protein 1 Gremlin Growth differentiation factor 2 Inhibin alpha chain Inhibin beta A chain Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Noggin Serine/threonine-protein kinase receptor Serine/threonine-protein kinase receptor Ski oncogene Transforming growth factor beta receptor 3 Ubiquitin conjugating enzyme E2 D3 Zinc finger FYVE domain-containing protein receptor protein serine/threonine kinase receptor protein serine/threonine kinase receptor protein serine/threonine kinase receptor protein serine/threonine kinase	A0A7I8AUV5 A0A8I3MLM6 A0A8I3MRS8 A0A8I3MVJ8 A0A8I3N281 A0A8I3N723 A0A8I3N8R4 A0A8I3NCV3 A0A8I3NHH0 A0A8I3NM89 A0A8I3NU17 A0A8I3NW84 A0A8I3NYK2 A0A8I3NZI6 A0A8I3P2D1 A0A8I3P2Y0 A0A8I3P330 A0A8I3P4Q9 A0A8I3PB34 A0A8I3PG53 A0A8I3PG60 A0A8I3PPQ3 A0A8I3PZR5 A0A8I3Q270 A0A8I3QCM6 A0A8I3RR80 A0A8I3S5B1 A0A8I3S5W5 A0A8I3SCQ0	ACVR2A ACVR2B ACVRL1 BMP10 BMP2 BMPR1A BMPR1B BMPR2 CER1 CHRDL1 FSTL1 GDF2 GREM2 INHA INHBA NOG SKI SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SMURF1 SMURF2 TGFBR3 UBE2D1 UBE2D3 ZFYVE16	Canis familiaris (dog)
Sialic acid metabolism	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Beta-galactosidase Beta-galactoside alpha-2,6-sialyltransferase 2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase Carboxypeptidase Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Lactosylceramide alpha-2,3-sialyltransferase N-acetylneuraminate lyase N-acetylneuraminate synthase N-acylneuraminate cytidylyltransferase ST3 beta-galactoside alpha-2,3-sialyltransferase 3 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 Sialidase-1 Solute carrier family 17 member 5 Solute carrier family 35 member A1 Type 2 lactosamine alpha-2,3-sialyltransferase Uncharacterized protein alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase beta-galactoside alpha-(2,6)-sialyltransferase exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase	A0A8I3MKA0 A0A8I3MMF0 A0A8I3MQ19 A0A8I3MQZ3 A0A8I3MRB4 A0A8I3MRS4 A0A8I3MSL1 A0A8I3MWM9 A0A8I3MZA8 A0A8I3N2X1 A0A8I3N3C9 A0A8I3N9F9 A0A8I3NB27 A0A8I3NB67 A0A8I3NFK8 A0A8I3NHI8 A0A8I3NN43 A0A8I3NNC5 A0A8I3NR40 A0A8I3NVQ5 A0A8I3P0Y9 A0A8I3P9I7 A0A8I3PBB8 A0A8I3PGV9 A0A8I3Q6S3 A0A8I3RSF2 A0A8I3RV22 A0A8I3RWY3 A0A8I3RZ95 A0A8I3S0P4 A0A8I3S2B0 A0A8I3S5C7 Q9TRY9	CMAS CTSA GLB1 GNE NANP NANS NEU1 NEU2 NEU3 NEU4 NPL SLC17A5 SLC35A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6	Canis familiaris (dog)
Serotonin receptors	5-hydroxytryptamine receptor 1A 5-hydroxytryptamine receptor 1B 5-hydroxytryptamine receptor 1D 5-hydroxytryptamine receptor 1E 5-hydroxytryptamine receptor 1F 5-hydroxytryptamine receptor 2A 5-hydroxytryptamine receptor 2B 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine receptor 4 5-hydroxytryptamine receptor 5A 5-hydroxytryptamine receptor 7 G-protein coupled receptors family 1 profile domain-containing protein	A0A8I3MN28 A0A8I3N6U6 A0A8I3NAA7 A0A8I3NLJ6 A0A8I3NMV4 A0A8I3PC67 A0A8I3RXP5 A0A8I3S1Q6 A0A8I3S5I1 A0A8I3S709 O46635 P79250	5-HTR2A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7	Canis familiaris (dog)
Sensory perception of sweet, bitter, and umami (glutamate) taste	Bitter taste receptor T2R43 G protein subunit alpha transducin 3 G protein subunit gamma 13 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Inositol 1,4,5-trisphosphate receptor Taste 1 receptor member 1 Taste receptor type 1 member 3 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2	A0A8I3NKU5 A0A8I3PJF2 A0A8I3PQY2 A0A8I3PRQ9 A0A8I3Q2P2 A0A8I3Q7L4 A0A8I3QV74 A0A8I3S925 A0A8I3S929 A0A8I3SCV7 P62872 P79147 Q2ABD0 Q2ABD1 Q2ABD4 Q2ABD5 Q2ABD6 Q2ABD8 Q2ABE0	CAFA-T2R43 GNAT3 GNB1 GNB3 GNG13 ITPR3 LOC100682759 TAS1R1 TAS1R3 TAS2R1 TAS2R10 TAS2R3 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R5 TAS2R7	Canis familiaris (dog)	G58161NS
Scavenging by Class A Receptors	Apolipoprotein A-I Apolipoprotein B Apolipoprotein E Calreticulin Endoplasmin Macrophage receptor with collagenous structure Macrophage scavenger receptor 1 Secretoglobin family 3A member 2	A0A8I3MSG4 A0A8I3NM03 A0A8I3NVT5 A0A8I3PTI1 A0A8I3QIL7 A0A8I3S4D1 P18649 P41148	APOA1 APOB APOE CALR GRP94 HSP90B1 HSPC4 MARCO MSR1 SCGB3A2 TRA1	Canis familiaris (dog)
SHC-mediated cascade:FGFR3	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor 3 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Multifunctional fusion protein SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Uncharacterized protein small monomeric GTPase	A0A0B4J199 A0A7U3JWB8 A0A8I3MIK8 A0A8I3NHF3 A0A8I3NS74 A0A8I3NTD6 A0A8I3NUU1 A0A8I3NV07 A0A8I3PJY6 A0A8I3PSP7 A0A8I3PT69 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3SAY5 J9P0B3 J9P3I7 J9P8K0 Q20FD0	FGF1 FGF16 FGF17 FGF18 FGF20 FGF23 FGF3A FGF4 FGF4B FGF4C FGF5 FGF7A FGF8 FGF8B FGF9 FGFR3 GRB2 HRAS KRAS NRAS SHC1 SOS1	Canis familiaris (dog)
SHC-mediated cascade:FGFR2	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Multifunctional fusion protein SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Uncharacterized protein small monomeric GTPase	A0A0B4J199 A0A7U3JWB8 A0A8I3MIK8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NUU1 A0A8I3NV07 A0A8I3NYK3 A0A8I3P6D2 A0A8I3PJY6 A0A8I3PSP7 A0A8I3PT69 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 J9P8K0 P79150 Q20FD0	FGF1 FGF10 FGF16 FGF17 FGF18 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF4C FGF5 FGF6 FGF7 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR2 GRB2 HRAS KGF KRAS NRAS SHC1 SOS1	Canis familiaris (dog)
SHC-mediated cascade:FGFR1	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Klotho Multifunctional fusion protein SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 small monomeric GTPase	A0A0B4J199 A0A7U3JWB8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NKX5 A0A8I3NNZ2 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NUU1 A0A8I3NV07 A0A8I3NYK3 A0A8I3PJY6 A0A8I3PSP7 A0A8I3PT69 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 Q20FD0	FGF1 FGF10 FGF17 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF5 FGF6 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 GRB2 HRAS KL KRAS NRAS SHC1 SOS1	Canis familiaris (dog)
Role of phospholipids in phagocytosis	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma 5'-3' exonuclease PLD3 Fc fragment of IgG receptor Ia Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Low affinity immunoglobulin gamma Fc region receptor III-A Low affinity immunoglobulin gamma Fc region receptor III-A Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide phospholipase C Phosphoinositide-3-kinase regulatory subunit 2 Phospholipase Phospholipase Phospholipid phosphatase 4 Protein kinase C delta type Protein kinase C epsilon type T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phospholipase A2	A0A5F4C2B1 A0A8I3MFY1 A0A8I3MMY6 A0A8I3MQR0 A0A8I3MV98 A0A8I3N971 A0A8I3NEM6 A0A8I3NWR3 A0A8I3NYY2 A0A8I3NZG2 A0A8I3P1N5 A0A8I3P2M2 A0A8I3P2N6 A0A8I3P3G0 A0A8I3P3T7 A0A8I3P4X4 A0A8I3P4Y5 A0A8I3P6V2 A0A8I3P941 A0A8I3PAT0 A0A8I3PCM7 A0A8I3PD67 A0A8I3PDU9 A0A8I3PL11 A0A8I3PQA6 A0A8I3PT15 A0A8I3PTN6 A0A8I3PUA5 A0A8I3PUN5 A0A8I3PUP2 A0A8I3PUS1 A0A8I3PV91 A0A8I3PVB5 A0A8I3PVC4 A0A8I3PVG3 A0A8I3PWK4 A0A8I3PWT0 A0A8I3PWT3 A0A8I3PXN9 A0A8I3PXQ9 A0A8I3PYF1 A0A8I3PZJ7 A0A8I3Q258 A0A8I3Q590 A0A8I3Q5E2 A0A8I3QCV8 A0A8I3QD99 A0A8I3QE86 A0A8I3QF04 A0A8I3QHH1 A0A8I3QQ00 A0A8I3S0G9 A0A8I3S0K3 A0A8I3S3N2 A0A8I3S6H5 A0A8I3S9C3 A0A8I3SAS3 A0A8I3SAS7 A0A8I3SCI7 E2RP87	CD247 CD3G FCGR1A FCGR2B FCGR3A LOC478984 PIK3CA PIK3CB PIK3R1 PIK3R2 PLA2G6 PLCG1 PLCG2 PLD1 PLD2 PLD3 PLD4 PLPP4 PLPP5 PRKCD PRKCE SYK	Canis familiaris (dog)
Rhesus glycoproteins mediate ammonium transport.	Ammonium transporter Rh type A Ammonium transporter Rh type B Ammonium transporter Rh type C	A0A8I3MHG4 A0A8I3MZM2 Q4VUI0	RHAG RHBG RHCG	Canis familiaris (dog)
Reuptake of GABA	Sodium- and chloride-dependent betaine transporter Solute carrier family 6 member 13 Transporter Transporter	A0A8I3N6A1 A0A8I3Q066 A0A8I3RV00 P27799	SLC6A1 SLC6A11 SLC6A12 SLC6A13	Canis familiaris (dog)
Response to elevated platelet cytosolic Ca2+	Protein kinase C Protein kinase C Protein kinase C	A0A8I3MI53 A0A8I3PUQ8 E2R2X3	PRKCA PRKCB PRKCG	Canis familiaris (dog)
Removal of aminoterminal propeptides from gamma-carboxylated proteins	Coagulation factor IX Coagulation factor VII Coagulation factor X Growth arrest specific 6 Osteocalcin Prothrombin Vitamin K-dependent protein C Vitamin K-dependent protein S furin	A0A8I3N1T9 A0A8I3N921 A0A8I3PQV5 A0A8I3PUT1 A0A8I3Q1K1 A0A8I3QAV8 A0A8I3S489 A0A8I3SCE7 Q28278	BGLAP F10 F2 F7 F9 FURIN GAS6 PROC PROS1	Canis familiaris (dog)
Relaxin receptors	Insulin-like 3 Relaxin 2 Relaxin family peptide receptor 1 Relaxin family peptide receptor 3 Relaxin receptor 2 Relaxin-3	A0A8I3NLX3 A0A8I3PPP9 A0A8I3RPW6 A0A8I3RZ39 Q5XM32 Q6X7V3	INSL3 LGR8 RLF RLN2 RLN3 RXFP1 RXFP2 RXFP3	Canis familiaris (dog)
Regulation of insulin secretion	ATP binding cassette subfamily C member 8 ATP-sensitive inward rectifier potassium channel 11 Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 Solute carrier family 2, facilitated glucose transporter member 1 Solute carrier family 2, facilitated glucose transporter member 2 Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 Voltage-dependent P/Q-type calcium channel subunit alpha Voltage-dependent R-type calcium channel subunit alpha cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase	A0A8I3MU54 A0A8I3N0M1 A0A8I3NPX9 A0A8I3NRK7 A0A8I3NVA4 A0A8I3P8U8 A0A8I3PMW4 A0A8I3PRW9 A0A8I3PW63 A0A8I3PZ28 A0A8I3Q2Z6 A0A8I3Q3U9 A0A8I3QY31 A0A8I3S0T4 A0A8I3S464	ABCC8 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 KCNJ11 PRKACA PRKACB RAPGEF3 RAPGEF4 SLC2A1 SLC2A2	Canis familiaris (dog)	G58161NS
Regulation of expression of SLITs and ROBOs	Dystroglycan 1 Slit guidance ligand 2	A0A8I3NQC4 Q9TSZ6	DAG1 SLIT2	Canis familiaris (dog)
Regulation of actin dynamics for phagocytic cup formation	Abl interactor 1 Abl interactor 2 Actin gamma 1 Actin, cytoplasmic 1 Actin-related protein 2/3 complex subunit 3 Actin-related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2/3 complex subunit Actin-related protein 2/3 complex subunit Actin-related protein 2 Actin-related protein 3 Adapter molecule crk Arp2/3 complex 34 kDa subunit Brain-specific angiogenesis inhibitor 1-associated protein 2 CYRIA/CYRIB Rac1 binding domain-containing protein Cell division control protein 42 homolog Cytoplasmic FMR1-interacting protein Cytoplasmic protein Dedicator of cytokinesis 1 Engulfment and cell motility 1 Engulfment and cell motility 2 Fc fragment of IgG receptor Ia Focal adhesion kinase 1 Growth factor receptor bound protein 2 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein LIM domain kinase 1 Low affinity immunoglobulin gamma Fc region receptor III-A Low affinity immunoglobulin gamma Fc region receptor III-A Mitogen-activated protein kinase Mitogen-activated protein kinase Myosin IC Myosin IXB Myosin VA Myosin X Myosin-2 Myosin-9 NCK associated protein 1 like NCK interacting protein with SH3 domain NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Nck-associated protein 1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Vav guanine nucleotide exchange factor 1 Vav guanine nucleotide exchange factor 2 Vav guanine nucleotide exchange factor 3 WAS/WASL interacting protein family member 1 WASP like actin nucleation promoting factor Wiskott-Aldrich syndrome protein family member Wiskott-Aldrich syndrome protein family member Wiskott-Aldrich syndrome protein family member non-specific serine/threonine protein kinase	A0A8I3MFY1 A0A8I3MIN4 A0A8I3MKB3 A0A8I3ML42 A0A8I3MNR2 A0A8I3MPK0 A0A8I3MR78 A0A8I3MV98 A0A8I3MVD4 A0A8I3N156 A0A8I3N1W7 A0A8I3N9N7 A0A8I3N9V3 A0A8I3NA65 A0A8I3NC73 A0A8I3NE73 A0A8I3NEM6 A0A8I3NEW9 A0A8I3NEZ8 A0A8I3NGQ0 A0A8I3NGY2 A0A8I3NH46 A0A8I3NMF7 A0A8I3NMY1 A0A8I3NNZ1 A0A8I3NU35 A0A8I3NVZ2 A0A8I3NWR3 A0A8I3NZ88 A0A8I3NZQ2 A0A8I3P1N5 A0A8I3P2M2 A0A8I3P2N6 A0A8I3P3G0 A0A8I3P3T7 A0A8I3P4X4 A0A8I3P4Y5 A0A8I3P6V2 A0A8I3P7Z3 A0A8I3P8D4 A0A8I3P8Q3 A0A8I3P941 A0A8I3PD67 A0A8I3PDU9 A0A8I3PGP9 A0A8I3PL11 A0A8I3PPQ5 A0A8I3PQA6 A0A8I3PT15 A0A8I3PT69 A0A8I3PTN6 A0A8I3PUA5 A0A8I3PUN5 A0A8I3PUP2 A0A8I3PUS1 A0A8I3PV91 A0A8I3PVB5 A0A8I3PVC4 A0A8I3PVG3 A0A8I3PWK4 A0A8I3PXN0 A0A8I3PXN9 A0A8I3PXQ9 A0A8I3PYF1 A0A8I3PZH0 A0A8I3PZP0 A0A8I3Q1Q8 A0A8I3Q2I4 A0A8I3Q5E2 A0A8I3Q9N2 A0A8I3QBP5 A0A8I3QCV8 A0A8I3QD99 A0A8I3QE86 A0A8I3QF04 A0A8I3QHH1 A0A8I3QQ00 A0A8I3RQD0 A0A8I3RQZ5 A0A8I3RVS9 A0A8I3RXY6 A0A8I3S0G9 A0A8I3S0K3 A0A8I3S4H5 A0A8I3S602 A0A8I3S6D8 A0A8I3S6H5 A0A8I3S9C3 A0A8I3SAS3 A0A8I3SAS7 A0A8I3SAU8 E2RP87 O18840 P60952 P62999 Q076A7	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BTK CD247 CD3G CDC42 CRK CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FCGR1A FCGR2B FCGR3A GRB2 HSP90AA1 HSP90AB1 LIMK1 LOC478984 MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD NF2 PAK1 PTK2 RAC1 SYK VAV1 VAV2 VAV3 WASF1 WASF2 WASF3 WASL WIPF1	Canis familiaris (dog)
Regulation of TNFR1 signaling	Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 CAP-Gly domain containing linker protein 3 Caspase 8 Caspase 9 E2 ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase XIAP IkappaB kinase Inhibitor of nuclear factor kappa B kinase subunit epsilon Inhibitor of nuclear factor kappa-B kinase subunit alpha MAP kinase-activating death domain protein NF-kappa-B essential modulator Optineurin RBR-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RanBP-type and C3HC4-type zinc finger-containing protein 1 Receptor interacting serine/threonine kinase 1 Serine/threonine-protein kinase Signal peptide peptidase like 2A Signal peptide peptidase like 2B Small ribosomal subunit protein RACK1 Spermatogenesis associated 2 TANK binding kinase 1 TNF receptor-associated factor TNFR-Cys domain-containing protein Tax1 binding protein 1 Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor Ubiquitin B Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin conjugating enzyme E2 D3 Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A8I3MA34 A0A8I3MAP5 A0A8I3MDM0 A0A8I3MJ82 A0A8I3MKR0 A0A8I3MLM6 A0A8I3MMN5 A0A8I3MQC7 A0A8I3MSL4 A0A8I3MYA4 A0A8I3N1V1 A0A8I3N4F2 A0A8I3NEJ2 A0A8I3NFB9 A0A8I3NK16 A0A8I3NLZ9 A0A8I3NP69 A0A8I3NS04 A0A8I3P2P4 A0A8I3P499 A0A8I3PLX1 A0A8I3PRU0 A0A8I3PS24 A0A8I3PT83 A0A8I3PW29 A0A8I3PWL6 A0A8I3PZS6 A0A8I3Q155 A0A8I3Q3L1 A0A8I3QYD0 A0A8I3RSQ2 A0A8I3RUY7 A0A8I3RZA9 A0A8I3RZI9 A0A8I3S2L7 A0A8I3S5W5 A0A8I3S792 A0A8I3S794 A1E2V0 P51742 P63050 Q38IV1 Q38JA9	BIRC2 BIRC3 BIRC4 CASP8 CASP9 CHUK CLIP3 CYLD IKBKB IKBKE IKBKG IRF9 MADD MIB2 OPTN OTUD1 OTUD7B RACK1 RBCK1 RIPK1 RPS27A SPATA2 SPPL2A SPPL2B STUB1 TAX1BP1 TBK1 TNF TNFA TNFAIP3 TNFRSF1A TNFSF2 TRADD TRAF2 UBA52 UBB UBC UBCEP2 UBE2D1 UBE2D2 UBE2D3 UBE2L3 ULK1 USP2 USP21 USP4 XIAP	Canis familiaris (dog)
Regulation of KIT signaling	E3 ubiquitin-protein ligase CBL Growth factor receptor bound protein 2 Kit ligand Mast/stem cell growth factor receptor Kit Protein kinase C SH2B adaptor protein 2 SH2B adaptor protein 3 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type	A0A8I3MBU4 A0A8I3ML64 A0A8I3MTK2 A0A8I3NAC6 A0A8I3P3X1 A0A8I3PT69 A0A8I3PUN0 A0A8I3PUQ8 A0A8I3PWC6 A0A8I3QRG3 A0A8I3S3D9 A0A8I3SBF9 O97799 Q06220	CBL FYN GRB2 KIT KITLG LCK LYN MGF PRKCA PTPN6 SH2B2 SH2B3 SOS1 SRC YES1	Canis familiaris (dog)
Regulation of IGF Activity by IGFBP	Albumin Alpha 1 antitrypsin Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-2-HS-glycoprotein Alpha-L-fucosidase Alpha-fetoprotein Ameloblastin Amelogenin X isoform Amelotin Amyloid beta precursor like protein 2 Amyloid-beta A4 protein Anoctamin Antithrombin-III Apolipoprotein A-I Apolipoprotein A-II Apolipoprotein A-V Apolipoprotein B Apolipoprotein E Apolipoprotein L3 Apolipoprotein L3 BPI fold containing family B member 2 Bone morphogenetic protein 4 C4a anaphylatoxin CCN family member 1 Cadherin-2 Calumenin Chordin like 1 Coagulation factor V Complement C3 Cytoskeleton associated protein 4 Dentin matrix acidic phosphoprotein 1 Disintegrin and metalloproteinase domain-containing protein 10 DnaJ homolog subfamily C member 3 Enamelin Endoplasmin FAM20 C-terminal domain-containing protein FAM20A golgi associated secretory pathway pseudokinase Fibrillin 1 Fibrinogen alpha chain Fibroblast growth factor 23 Fibronectin Follistatin like 3 Follistatin-related protein 1 Galectin 1 Glypican-3 Golgi membrane protein 1 Growth arrest specific 6 Histidine rich calcium binding protein Insulin like growth factor binding protein 6 Insulin like growth factor binding protein 7 Insulin-like growth factor I Insulin-like growth factor II Insulin-like growth factor-binding protein 2 Insulin-like growth factor-binding protein 3 Insulin-like growth factor-binding protein 4 Insulin-like growth factor-binding protein 5 Inter-alpha-trypsin inhibitor heavy chain 2 Interleukin-6 Kinectin 1 Kininogen 1 Latent transforming growth factor beta binding protein 1 MIA SH3 domain ER export factor 3 Macrophage colony-stimulating factor 1 Matrilin 3 Matrix extracellular phosphoglycoprotein Matrix remodeling-associated protein 8 Melanotransferrin Membrane bound transcription factor peptidase, site 1 Menin Metalloproteinase inhibitor 1 Milk fat globule EGF and factor V/VIII domain containing Multiple EGF like domains 6 Nucleobindin-1 Pappalysin 1 Pappalysin 2 Patatin like phospholipase domain containing 2 Proenkephalin-A Protein disulfide-isomerase A6 Protein disulfide-isomerase Protein kinase C substrate 80K-H Reticulocalbin 1 SPARC like 1 Secreted phosphoprotein 1 Secreted phosphoprotein 24 Secretogranin-1 Secretogranin-2 Secretogranin-3 Serine protease Serpin family D member 1 Stanniocalcin-2 Sulfhydryl oxidase Tenascin C Trans-golgi network protein 2 Transmembrane protein 132A Uncharacterized protein Uncharacterized protein Uncharacterized protein VGF nerve growth factor inducible Versican core protein Vitamin K-dependent protein C [Wnt protein] O-palmitoleoyl-L-serine hydrolase ferroxidase von Willebrand factor A domain-containing protein 1	A0A0B4J199 A0A8I3MBU3 A0A8I3MBV3 A0A8I3MD84 A0A8I3MKS3 A0A8I3MKU0 A0A8I3MLH1 A0A8I3MRY5 A0A8I3MSG4 A0A8I3MSR8 A0A8I3MVA9 A0A8I3MY68 A0A8I3MZB7 A0A8I3N0D8 A0A8I3N1E6 A0A8I3N365 A0A8I3N3Q6 A0A8I3N5X9 A0A8I3N8F9 A0A8I3N8K1 A0A8I3N8X3 A0A8I3N9A4 A0A8I3NA54 A0A8I3NAE2 A0A8I3NAG2 A0A8I3NBG6 A0A8I3NBI4 A0A8I3NBI7 A0A8I3NFV4 A0A8I3NH95 A0A8I3NHN1 A0A8I3NHZ1 A0A8I3NI15 A0A8I3NIA5 A0A8I3NLM1 A0A8I3NLT2 A0A8I3NN59 A0A8I3NPQ9 A0A8I3NQA0 A0A8I3NR35 A0A8I3NSE7 A0A8I3NTU0 A0A8I3NXQ1 A0A8I3NY94 A0A8I3P0M4 A0A8I3P1E4 A0A8I3P1V2 A0A8I3P1W2 A0A8I3P261 A0A8I3P2Y2 A0A8I3P735 A0A8I3P7V0 A0A8I3P874 A0A8I3P9H6 A0A8I3PA47 A0A8I3PB34 A0A8I3PED8 A0A8I3PEI1 A0A8I3PI20 A0A8I3PIK8 A0A8I3PM36 A0A8I3PMB5 A0A8I3PMF7 A0A8I3PPY1 A0A8I3PSD1 A0A8I3PTJ6 A0A8I3PTU8 A0A8I3PU47 A0A8I3PWU3 A0A8I3PX33 A0A8I3Q0F7 A0A8I3Q0M1 A0A8I3Q1K1 A0A8I3Q1Q3 A0A8I3Q2P4 A0A8I3Q2T3 A0A8I3Q4H4 A0A8I3Q662 A0A8I3QBE2 A0A8I3QN81 A0A8I3QNP3 A0A8I3RP80 A0A8I3RQL9 A0A8I3RRH5 A0A8I3RT41 A0A8I3RYZ7 A0A8I3S0I3 A0A8I3S0P1 A0A8I3S3D7 A0A8I3S4D1 A0A8I3S5B1 A0A8I3S6A4 A0A8I3S8V0 A0A8I3S915 A1ILJ0 A2SXS5 E2RAK7 F6PLF2 J9PBH8 P18649 P33712 P41148 Q28278	ADAM10 AFP AHSG ALB AMBN AMELX AMTN ANO8 APLP2 APOA1 APOA2 APOA5 APOB APOE APP BMP15 BMP4 BPIFB2 C3 CALU CCN1 CDH2 CHGB CHRDL1 CKAP4 COA5 CP CSF1 DMP1 DNAJC3 ENAM F5 FAM20A FAM20C FBN1 FGA FGF23 FGF8B FN1 FSTL1 FSTL3 FUCA2 GAS6 GOLM1 GPC3 GRP94 HRC HSP90B1 HSPC4 IGF1 IGF2 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGFIA IL6 ITIH2 KNG1 KTN1 LGALS1 LOC102156332 LOC481722 LOC607874 LTBP1 MATN3 MBTPS1 MEGF6 MELTF MEN1 MEPE MFGE8 MIA3 MXRA8 NOTUM NUCB1 P4HB PAPPA PAPPA2 PDIA6 PENK PNPLA2 PRKCSH PROC PRSS23 QSOX1 RCN1 SCG2 SCG3 SERPINA1 SERPINC1 SERPIND1 SPARCL1 SPP1 SPP2 STC2 TGOLN2 TIMP1 TMEM132A TNC TRA1 VCAN VGF VWA1 WFS1	Canis familiaris (dog)
Regulation of IFNG signaling	Fibronectin type-III domain-containing protein Interferon gamma Protein inhibitor of activated STAT 1 Signal transducer and activator of transcription Small ubiquitin-related modifier 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein	A0A8I3MY73 A0A8I3MZ64 A0A8I3NU62 A0A8I3NVH4 A0A8I3NZS0 A0A8I3P2U6 A0A8I3PSA1 A0A8I3QCJ0 A0A8I3RS40 P42161	IFNG IFNGR1 IFNGR2 JAK1 JAK2 PIAS1 PTPN2 SOCS3 STAT1 SUMO1	Canis familiaris (dog)
Regulation of Glucokinase by Glucokinase Regulatory Protein	Aladin WD repeat nucleoporin BIG2 domain-containing protein Glucokinase regulator Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup93 Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nucleoporin 133 Nucleoporin 153 Nucleoporin 155 Nucleoporin 160 Nucleoporin 205 Nucleoporin 214 Nucleoporin 37 Nucleoporin 43 Nucleoporin 50 Nucleoporin 54 Nucleoporin 58 Nucleoporin 62 Nucleoporin 88 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoprotein TPR POM121 transmembrane nucleoporin C Phosphotransferase Protein SEC13 homolog Uncharacterized protein	A0A8I3MJ67 A0A8I3MKP8 A0A8I3MMX0 A0A8I3MS44 A0A8I3MW92 A0A8I3MW93 A0A8I3MZ55 A0A8I3N5H9 A0A8I3N8Q5 A0A8I3N975 A0A8I3N9C4 A0A8I3NAH9 A0A8I3NAY7 A0A8I3NDG5 A0A8I3NIY6 A0A8I3NMR5 A0A8I3NQA4 A0A8I3NV53 A0A8I3NZW0 A0A8I3P0U9 A0A8I3P537 A0A8I3P769 A0A8I3PAE6 A0A8I3PBR9 A0A8I3PUC1 A0A8I3Q2U4 A0A8I3S484 A0A8I3S533 A0A8I3S9D7	AAAS GCK GCKR NDC1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP42 NUP43 NUP50 NUP54 NUP58 NUP62 NUP85 NUP88 NUP93 NUP98 POM121C RANBP2 SEC13 TPR	Canis familiaris (dog)	G58161NS
Regulation of Complement cascade	C3a anaphylatoxin chemotactic receptor C4a anaphylatoxin C5a anaphylatoxin chemotactic receptor 1 CD19 molecule Carboxypeptidase B2 Carboxypeptidase N subunit 1 Carboxypeptidase N subunit 2 Clusterin Complement C1q B chain Complement C1q C chain Complement C1q subcomponent subunit A Complement C1s Complement C2 Complement C3 Complement C5 Complement C5a receptor 2 Complement C7 Complement C8 alpha chain Complement C8 gamma chain Complement component C6 Complement component C8 beta chain Complement component C9 Complement factor B Complement factor I Elastase, neutrophil expressed Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein MAC-inhibitory protein Membrane cofactor protein Prothrombin Serpin family G member 1 Sushi domain-containing protein Sushi domain-containing protein Sushi domain-containing protein Sushi domain-containing protein Tetraspanin Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Vitronectin complement subcomponent C1r	A0A8I3MAL2 A0A8I3MBH0 A0A8I3MDV8 A0A8I3MFV5 A0A8I3MKD7 A0A8I3MKJ7 A0A8I3MLF7 A0A8I3MPF4 A0A8I3MQ72 A0A8I3MQK6 A0A8I3MRL7 A0A8I3N180 A0A8I3N567 A0A8I3NC13 A0A8I3NH95 A0A8I3NLH3 A0A8I3NQA0 A0A8I3NQQ5 A0A8I3NT81 A0A8I3NVC1 A0A8I3NWR3 A0A8I3NYS7 A0A8I3P0T6 A0A8I3P1N5 A0A8I3P2M2 A0A8I3P2N6 A0A8I3P3T7 A0A8I3P4X4 A0A8I3P4Y5 A0A8I3P6V2 A0A8I3P941 A0A8I3PD67 A0A8I3PDU9 A0A8I3PJQ7 A0A8I3PL11 A0A8I3PQA6 A0A8I3PT15 A0A8I3PTN6 A0A8I3PTW0 A0A8I3PUA5 A0A8I3PUL5 A0A8I3PUN5 A0A8I3PUP2 A0A8I3PUS1 A0A8I3PUT1 A0A8I3PV91 A0A8I3PVB5 A0A8I3PVC4 A0A8I3PVG3 A0A8I3PWK4 A0A8I3PXN9 A0A8I3PXQ9 A0A8I3PYF1 A0A8I3Q044 A0A8I3Q2F2 A0A8I3Q318 A0A8I3Q5E2 A0A8I3QCV8 A0A8I3QD99 A0A8I3QE86 A0A8I3QF04 A0A8I3RQ73 A0A8I3RQX0 A0A8I3RSI3 A0A8I3RSN2 A0A8I3RUJ7 A0A8I3S0G9 A0A8I3S0K3 A0A8I3S1V7 A0A8I3S6H5 A0A8I3S7V8 A0A8I3S9C3 A0A8I3SAS3 A0A8I3SAS7 P25473 Q8MJD1	C1QA C1QB C1QC C1R C1S C2 C3 C3AR1 C5 C5AR1 C5AR2 C6 C7 C8A C8B C8G C9 CD19 CD55 CD59 CD81 CFB CFH CFHR5 CFI CLU CPB2 CPN1 CPN2 ELA2 ELANE F2 LOC102156626 LOC481722 LOC490269 SEBOX SERPING1	Canis familiaris (dog)

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