GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **76 - 100** of **268** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol	Organism	GlyTouCan ID
Interleukin-2 signaling	Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 SHC-transforming protein 1 Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase non-specific protein-tyrosine kinase	A0A8I3MVN6 A0A8I3N974 A0A8I3NAC6 A0A8I3NUU1 A0A8I3P3G0 A0A8I3RRY0 A0A8I3RS40 A0A8I3RVE7 A0A8I3RYS0 A0A8I3S4Z2 Q29416	IL2 IL2RA IL2RB JAK1 JAK3 LCK PTK2B SHC1 STAT5A STAT5B SYK	Canis familiaris (dog)
Cilium Assembly	Alpha-tubulin N-acetyltransferase 1 Histone deacetylase 6	A0A8I3MV46 A0A8I3Q5U6	ATAT1 HDAC6 MEC17	Canis familiaris (dog)
Gastrin-CREB signalling pathway via PKC and MAPK	Gastrin/cholecystokinin type B receptor Gastrin Mitogen-activated protein kinase Mitogen-activated protein kinase Mitogen-activated protein kinase Ribosomal protein S6 kinase Ribosomal protein S6 kinase cAMP responsive element binding protein 1 non-specific serine/threonine protein kinase	A0A8I3MV42 A0A8I3NAU2 A0A8I3P721 A0A8I3PZN8 A0A8I3PZP0 A0A8I3RQD0 A0A8I3S2U7 P01353 P30552	CCKBR CREB1 GAS GAST MAPK1 MAPK3 MAPK7 RPS6KA1 RPS6KA2 RPS6KA3	Canis familiaris (dog)
Vitamin B5 (pantothenate) metabolism	4'-phosphopantetheine phosphatase Fatty acid synthase L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Mitochondrial coenzyme A transporter SLC25A42 PDZ domain-containing protein 11 Pantetheinase Solute carrier family 25 member 16 Solute carrier family 5 member 6	A0A8I3MUX5 A0A8I3MVX3 A0A8I3MY61 A0A8I3PCZ1 A0A8I3Q2U7 A0A8I3RQN4 A0A8I3S3J2 Q9TSX8	AASDHPPT FASN PANK4 PDZD11 SLC25A16 SLC25A42 SLC5A6 VNN1	Canis familiaris (dog)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Cytochrome P450 family 8 subfamily B member 1 Prostacyclin synthase Prostaglandin E synthase 2 Prostaglandin E synthase Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Prostaglandin-H2 D-isomerase Thromboxane-A synthase carbonyl reductase (NADPH) glutathione transferase	A0A8I3MUQ9 A0A8I3PFY5 A0A8I3PJM8 A0A8I3PV18 A0A8I3Q8L4 A0SYQ0 B4YY03 E5RQH2 Q8HZR1 Q8SPQ9	CBR1 COX-2 COX1 CYP8B1 H-PGDS HPGDS PGES PTGDS PTGES PTGES2 PTGIS PTGS1 PTGS2 TBXAS1	Canis familiaris (dog)
Interleukin-4 and Interleukin-13 signaling	Endoplasmin Interleukin 13 receptor subunit alpha 1 Interleukin-13 receptor subunit alpha-2 Interleukin-13 Interleukin-4 receptor subunit alpha Interleukin-4 Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Suppressor of cytokine signaling 5 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase	A0A8I3MUC6 A0A8I3NVH4 A0A8I3PDX4 A0A8I3PSA1 A0A8I3RS40 A0A8I3RV66 A0A8I3RXB9 A0A8I3S4Z2 A0A8I3S6B0 A0A8I3SBB2 O77762 P41148 Q95LF0 Q9N0W9	GRP94 HSP90B1 HSPC4 IL13 IL13RA1 IL13RA2 IL4 IL4R JAK1 JAK2 JAK3 SOCS5 STAT1 STAT3 STAT6 TRA1 TYK2	Canis familiaris (dog)
Regulation of insulin secretion	ATP binding cassette subfamily C member 8 ATP-sensitive inward rectifier potassium channel 11 Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 Solute carrier family 2, facilitated glucose transporter member 1 Solute carrier family 2, facilitated glucose transporter member 2 Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 Voltage-dependent P/Q-type calcium channel subunit alpha Voltage-dependent R-type calcium channel subunit alpha cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase	A0A8I3MU54 A0A8I3N0M1 A0A8I3NPX9 A0A8I3NRK7 A0A8I3NVA4 A0A8I3P8U8 A0A8I3PMW4 A0A8I3PRW9 A0A8I3PW63 A0A8I3PZ28 A0A8I3Q2Z6 A0A8I3Q3U9 A0A8I3QY31 A0A8I3S0T4 A0A8I3S464	ABCC8 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 KCNJ11 PRKACA PRKACB RAPGEF3 RAPGEF4 SLC2A1 SLC2A2	Canis familiaris (dog)	G58161NS
Presynaptic depolarization and calcium channel opening	Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Calcium voltage-gated channel auxiliary subunit alpha2delta 3 Calcium voltage-gated channel auxiliary subunit beta 4 Calcium voltage-gated channel auxiliary subunit gamma 4 Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 Voltage-dependent P/Q-type calcium channel subunit alpha Voltage-dependent R-type calcium channel subunit alpha Voltage-dependent calcium channel gamma-2 subunit	A0A8I3MU54 A0A8I3MZA1 A0A8I3N5F4 A0A8I3NMX5 A0A8I3NPX9 A0A8I3P8U8 A0A8I3PWX4 A0A8I3Q178 A0A8I3Q3U9 A0A8I3S464	CACNA1A CACNA1E CACNA2D2 CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG4	Canis familiaris (dog)
GDP-fucose biosynthesis	Fucose kinase Fucose-1-phosphate guanylyltransferase GDP-L-fucose synthase GDP-mannose 4,6-dehydratase L-fucose mutarotase Solute carrier family 35 member C1	A0A8I3MTB3 A0A8I3NTS0 A0A8I3NVI9 A0A8I3PWT5 A0A8I3Q1E5 A0A8I3RTZ0	FCSK FPGT FUOM GFUS GMDS SLC35C1	Canis familiaris (dog)	G85196CF G96881BQ
Histamine receptors	Histamine H1 receptor Histamine H2 receptor Histamine receptor H3 Histamine receptor H4	A0A8I3MSX9 A0A8I3NPW0 A0A8I3P226 P17124	HRH1 HRH2 HRH3 HRH4	Canis familiaris (dog)
Glycogen breakdown (glycogenolysis)	Alpha-1,4 glucan phosphorylase Alpha-1,4 glucan phosphorylase EF-hand domain-containing protein Glycogen debranching enzyme Lysosomal alpha-glucosidase Phosphorylase b kinase regulatory subunit Phosphorylase b kinase regulatory subunit Phosphorylase b kinase regulatory subunit glycogenin glucosyltransferase glycogenin glucosyltransferase phosphorylase kinase	A0A8I3MSQ7 A0A8I3N518 A0A8I3NJX4 A0A8I3P0C9 A0A8I3PK76 A0A8I3PPY6 A0A8I3PZN0 A0A8I3Q2T0 A0A8I3Q320 A0A8I3RSB1 A0A8I3S046	AGL CALM2 GAA GYG1 GYG2 PHKA1 PHKA2 PHKB PHKG2 PYGL PYGM	Canis familiaris (dog)	G58161NS
Sodium/Calcium exchangers	EF-hand domain-containing protein Sodium/calcium exchanger 1 Solute carrier family 24 member 2 Solute carrier family 24 member 3 Solute carrier family 24 member 4 Solute carrier family 24 member 5 Solute carrier family 8 member A2 Solute carrier family 8 member A3 Solute carrier family 8 member B1 Sorcin	A0A8I3MSQ7 A0A8I3MTJ5 A0A8I3NPM6 A0A8I3NX53 A0A8I3PDR2 A0A8I3PJY1 A0A8I3Q687 A0A8I3RTF4 A0A8I3RY81 P23685	CALM2 NCX1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC8A1 SLC8A2 SLC8A3 SLC8B1 SRI	Canis familiaris (dog)
Scavenging by Class A Receptors	Apolipoprotein A-I Apolipoprotein B Apolipoprotein E Calreticulin Endoplasmin Macrophage receptor with collagenous structure Macrophage scavenger receptor 1 Secretoglobin family 3A member 2	A0A8I3MSG4 A0A8I3NM03 A0A8I3NVT5 A0A8I3PTI1 A0A8I3QIL7 A0A8I3S4D1 P18649 P41148	APOA1 APOB APOE CALR GRP94 HSP90B1 HSPC4 MARCO MSR1 SCGB3A2 TRA1	Canis familiaris (dog)
Surfactant metabolism	ATP binding cassette subfamily A member 3 Adenosine receptor A2a Adhesion G protein-coupled receptor F5 Alpha-2A adrenergic receptor Alpha-2C adrenergic receptor C-type lectin domain-containing protein Coiled-coil domain containing 59 Colony stimulating factor 2 receptor subunit beta Cytoskeleton associated protein 4 Fibronectin type-III domain-containing protein GATA binding protein 6 LIM and cysteine rich domains 1 Napsin A aspartic peptidase P2Y purinoceptor 2 Palmitoyltransferase Pepsin A Pro-cathepsin H Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C SRCR domain-containing protein Sodium-dependent phosphate transport protein 2A Sodium-dependent phosphate transport protein 2B Transcription termination factor 1 Uncharacterized protein	A0A8I3MSD7 A0A8I3MZ62 A0A8I3NCW6 A0A8I3NFK5 A0A8I3NFY6 A0A8I3NHV8 A0A8I3NQ93 A0A8I3NR35 A0A8I3NUR4 A0A8I3NUT9 A0A8I3NWG1 A0A8I3NWJ3 A0A8I3NXR2 A0A8I3NZU4 A0A8I3P3J7 A0A8I3PBB4 A0A8I3PJM9 A0A8I3Q7S8 A0A8I3RTH9 A0A8I3RVV0 A0A8I3RW10 A0A8I3S9H9 P11617 Q9GMY6	ABCA3 ADGRF5 ADORA2A ADRA2A ADRA2C CCDC59 CKAP4 CSF2RA CSF2RB CTSH GATA6 LMCD1 LOC610540 NAPSA P2RY2 PGA PGNA RDC8 SFTPB SFTPC SFTPD SLC34A1 SLC34A2 TTF1 ZDHHC2	Canis familiaris (dog)
MET Receptor Activation	HGF activator Hepatocyte growth factor receptor Hepatocyte growth factor Hepsin Serine peptidase inhibitor, Kunitz type 1 Serine peptidase inhibitor, Kunitz type 2	A0A8I3MSC1 A0A8I3MW78 A0A8I3NGY1 A0A8I3NIY8 A0A8I3S6Z5 Q867B7	HGF HGFAC HPN MET SPINT1 SPINT2	Canis familiaris (dog)
Ficolins bind to repetitive carbohydrate structures on the target cell surface	MBL associated serine protease 1 MBL associated serine protease 2 Uncharacterized protein	A0A8I3MRI0 A0A8I3NLF4 A0A8I3PG15	FCN2 MASP1 MASP2	Canis familiaris (dog)	G49108TO G57321FI
Lectin pathway of complement activation	Collectin subfamily member 10 MBL associated serine protease 1 MBL associated serine protease 2 Uncharacterized protein	A0A8I3MRI0 A0A8I3NLF4 A0A8I3PG15 A0A8I3RST0	COLEC10 FCN2 MASP1 MASP2	Canis familiaris (dog)	G49108TO G57321FI
Signaling by ROBO receptors	Glypican-1 Slit guidance ligand 2 Slit guidance ligand 3	A0A8I3MRE2 A0A8I3NQC4 A0A8I3Q4U0	GPC1 SLIT2 SLIT3	Canis familiaris (dog)
Phase 4 - resting membrane potential	Inward rectifier potassium channel 2 Inward rectifier potassium channel Potassium channel domain-containing protein Potassium channel subfamily K member 9 Potassium channel subfamily K member Potassium inwardly rectifying channel subfamily J member 14 Potassium two pore domain channel subfamily K member 10 Potassium two pore domain channel subfamily K member 12 Potassium two pore domain channel subfamily K member 13 Potassium two pore domain channel subfamily K member 15 Potassium two pore domain channel subfamily K member 16 Potassium two pore domain channel subfamily K member 17 Potassium two pore domain channel subfamily K member 18 Potassium two pore domain channel subfamily K member 4 Potassium two pore domain channel subfamily K member 5 Potassium two pore domain channel subfamily K member 6 Potassium two pore domain channel subfamily K member 7	A0A8I3MR75 A0A8I3MTD8 A0A8I3MV05 A0A8I3N317 A0A8I3NAZ8 A0A8I3NNF9 A0A8I3NSP8 A0A8I3NUT1 A0A8I3NUY1 A0A8I3P863 A0A8I3Q3Z0 A0A8I3Q644 A0A8I3RRG3 A0A8I3S0J2 A0A8I3S6X0 F6KIF6 Q9MYY9	IRK1 KCNJ12 KCNJ14 KCNJ2 KCNK1 KCNK10 KCNK12 KCNK13 KCNK15 KCNK16 KCNK17 KCNK18 KCNK3 KCNK4 KCNK5 KCNK6 KCNK7 KCNK9	Canis familiaris (dog)
Integrin signaling	3-phosphoinositide-dependent protein kinase 1 Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Fibronectin Focal adhesion kinase 1 Integrin beta Integrin subunit alpha 2b RAS guanyl releasing protein 2 RAS guanyl-releasing protein 1 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 SHC-transforming protein 1 Talin 1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type small monomeric GTPase small monomeric GTPase von Willebrand factor von Willebrand factor	A0A8I3MQX7 A0A8I3N6K0 A0A8I3N737 A0A8I3NMY1 A0A8I3NUL4 A0A8I3NUU1 A0A8I3P3G0 A0A8I3P4Z0 A0A8I3PED8 A0A8I3PMU9 A0A8I3PW63 A0A8I3PWD7 A0A8I3PXV2 A0A8I3PZ28 A0A8I3Q868 A0A8I3RUF3 A0A8I3RVR5 A0A8I3SBF9 A0A8I3SCK0 Q28295	APBB1IP CSK F8VWF FN1 ITGA2B ITGB3 PDPK1 PTK2 PTPN1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SHC1 SRC SYK TLN1 VWF	Canis familiaris (dog)
Keratan sulfate degradation	Aggrecan core protein Beta-galactosidase Beta-galactosidase Beta-hexosaminidase Beta-hexosaminidase Fibromodulin Galactosidase beta 1 like Keratocan Lumican Mimecan N-acetylglucosamine-6-sulfatase Osteomodulin Proline and arginine rich end leucine rich repeat protein	A0A8I3MQQ0 A0A8I3MS95 A0A8I3MY15 A0A8I3NEJ3 A0A8I3P4B0 A0A8I3P684 A0A8I3PHJ7 A0A8I3PNW9 A0A8I3PS70 A0A8I3Q139 A0A8I3S110 A0A8I3S4Y4 Q9TRY9	ACAN FMOD GLB1 GLB1L GLB1L2 GNS HEXA HEXB KERA LUM OGN OMD PRELP	Canis familiaris (dog)	G09546QO G20239CJ G27025MB G50451AA G80016QC G82768YB G85384LV
Glycosphingolipid catabolism	Acid ceramidase Alpha-galactosidase Arylsulfatase A Arylsulfatase B Arylsulfatase F Arylsulfatase G Arylsulfatase K Arylsulfatase L Arylsulfatase family member H Arylsulfatase family member I Arylsulfatase family member J Beta-galactosidase Beta-galactosidase Beta-hexosaminidase Beta-hexosaminidase Carboxypeptidase Ectonucleotide pyrophosphatase/phosphodiesterase 7 Galactocerebrosidase Galactosidase beta 1 like Ganglioside GM2 activator Glucosylceramidase beta 3 (gene/pseudogene) Glucosylceramidase Mannose-6-phosphate receptor, cation dependent Neutral ceramidase Non-lysosomal glucosylceramidase Prosaposin Sialidase-1 Sphingomyelin phosphodiesterase Steroid sulfatase Sulfatase modifying factor 1 Sulfatase modifying factor 2 Uncharacterized protein exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase sphingomyelin phosphodiesterase sphingomyelin phosphodiesterase	A0A8I3MQM8 A0A8I3MQQ0 A0A8I3MQZ3 A0A8I3MY15 A0A8I3MZE8 A0A8I3N2H8 A0A8I3NC41 A0A8I3NF27 A0A8I3NH12 A0A8I3NJQ3 A0A8I3NK36 A0A8I3NK85 A0A8I3NN43 A0A8I3NQ68 A0A8I3NUS9 A0A8I3NZ71 A0A8I3PAY1 A0A8I3PBB8 A0A8I3PGV9 A0A8I3PHI8 A0A8I3PN86 A0A8I3PNW9 A0A8I3PP93 A0A8I3PPB0 A0A8I3PT92 A0A8I3Q0D0 A0A8I3Q139 A0A8I3Q2D2 A0A8I3Q545 A0A8I3Q695 A0A8I3RTW7 A0A8I3RW96 A0A8I3RZ95 A0A8I3S3Z3 Q32KH0 Q32KI4 Q9TRY9	ARSA ARSB ARSF ARSG ARSH ARSI ARSJ ARSK ARSL ASAH1 ASAH2 CTSA ENPP7 GALC GBA1 GBA2 GBA3 GLA GLB1 GLB1L GLB1L2 GM2A HEXA HEXB M6PR NEU1 NEU2 NEU3 NEU4 PSAP SMPD1 SMPD2 SMPD3 SMPD4 STS SUMF1 SUMF2 arsb	Canis familiaris (dog)	G09546QO G27025MB G58161NS
Prostanoid ligand receptors	Prostaglandin D2 receptor 2 Prostaglandin D2 receptor Prostaglandin E2 receptor EP1 subtype Prostaglandin E2 receptor EP2 subtype Prostaglandin E2 receptor EP3 subtype Prostaglandin E2 receptor EP4 subtype Prostaglandin F2-alpha receptor Thromboxane A2 receptor Uncharacterized protein	A0A8I3MQM7 A0A8I3MUB8 A0A8I3NCM2 A0A8I3NNN1 A0A8I3P5Y8 Q45FN0 Q9BGL8 Q9TU16 Q9XT82	PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR TBXA2R	Canis familiaris (dog)
TNF signaling	ADAM metallopeptidase domain 17 Receptor interacting serine/threonine kinase 1 TNF receptor-associated factor TNFR-Cys domain-containing protein Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor	A0A8I3MQC7 A0A8I3NEJ2 A0A8I3PPY4 A0A8I3Q3L1 A0A8I3S2L7 P51742	ADAM17 RIPK1 TNF TNFA TNFRSF1A TNFSF2 TRADD TRAF2	Canis familiaris (dog)
Atorvastatin ADME	ABC-type glutathione-S-conjugate transporter ATP binding cassette subfamily B member 1 Cytochrome P450 3A12 Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Paraoxonase 3 Paraoxonase Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member	A0A8I3MQC6 A0A8I3N2I4 A0A8I3NMC0 A0A8I3NUI6 A0A8I3PAM3 A0A8I3PDF6 A0A8I3PU35 A0A8I3PV37 A0A8I3SCV5 P24463	ABCB1 ABCC2 CYP3A12 LOC119868939 LOC119875773 LOC119876349 PON1 PON3 SLCO1B2 SLCO1B3 SLCO2B1	Canis familiaris (dog)

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