GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **101 - 125** of **268** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Vitamin B5 (pantothenate) metabolism	4'-phosphopantetheine phosphatase Fatty acid synthase L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Mitochondrial coenzyme A transporter SLC25A42 PDZ domain-containing protein 11 Pantetheinase Solute carrier family 25 member 16 Solute carrier family 5 member 6	A0A8I3MUX5 A0A8I3MVX3 A0A8I3MY61 A0A8I3PCZ1 A0A8I3Q2U7 A0A8I3RQN4 A0A8I3S3J2 Q9TSX8	AASDHPPT FASN PANK4 PDZD11 SLC25A16 SLC25A42 SLC5A6 VNN1	Canis familiaris (dog)
Phase 2 - plateau phase	Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Calcium voltage-gated channel auxiliary subunit gamma 4 Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent calcium channel gamma-6 subunit Voltage-dependent calcium channel gamma-7 subunit Voltage-dependent calcium channel gamma-8 subunit	A0A8I3MK78 A0A8I3N7S8 A0A8I3NMX5 A0A8I3NPX9 A0A8I3P8U8 A0A8I3Q178 A0A8I3QY31 A0A8I3RTB9	CACNA1C CACNA2D2 CACNB1 CACNB2 CACNG4 CACNG6 CACNG7 CACNG8	Canis familiaris (dog)
MET receptor recycling	ADP-ribosylation factor 6 Adapter molecule crk CRK like proto-oncogene, adaptor protein GRB2 associated binding protein 1 Golgi associated, gamma adaptin ear containing, ARF binding protein 3 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Ras-related protein Rab-4 Ras-related protein Rab-4B	A0A8I3MGJ1 A0A8I3MPX3 A0A8I3NGQ0 A0A8I3NGY1 A0A8I3NXI8 A0A8I3PN08 A0A8I3PT69 A0A8I3S696 P61017 Q867B7	ARF6 CRK CRKL GAB1 GGA3 GRB2 HGF MET RAB4A RAB4B	Canis familiaris (dog)
Phospholipase C-mediated cascade; FGFR2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Multifunctional fusion protein Uncharacterized protein	A0A0B4J199 A0A7U3JWB8 A0A8I3MIK8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NYK3 A0A8I3P6D2 A0A8I3PJY6 A0A8I3SAY5 A0A8I3SCI7 E2REX2 J9P0B3 J9P3I7 J9P8K0 P79150 Q20FD0	FGF1 FGF10 FGF16 FGF17 FGF18 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF4C FGF5 FGF6 FGF7 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR2 KGF PLCG1	Canis familiaris (dog)
Regulation of expression of SLITs and ROBOs	Dystroglycan 1 Slit guidance ligand 2	A0A8I3NQC4 Q9TSZ6	DAG1 SLIT2	Canis familiaris (dog)
ESR-mediated signaling	Estrogen receptor beta Estrogen receptor	A0A8I3MAV6 A0A8I3RRT3	ESR1 ESR2	Canis familiaris (dog)
Negative regulation of the PI3K/AKT network	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	P60483	MMAC1 PTEN	Canis familiaris (dog)
TNFR1-mediated ceramide production	Neutral sphingomyelinase activation associated factor Small ribosomal subunit protein RACK1 TNFR-Cys domain-containing protein Tumor necrosis factor sphingomyelin phosphodiesterase sphingomyelin phosphodiesterase	A0A8I3NH12 A0A8I3NK36 A0A8I3Q3L1 A0A8I3QLC7 A0A8I3RSQ2 P51742	NSMAF RACK1 SMPD2 SMPD3 TNF TNFA TNFRSF1A TNFSF2	Canis familiaris (dog)
Prostanoid ligand receptors	Prostaglandin D2 receptor 2 Prostaglandin D2 receptor Prostaglandin E2 receptor EP1 subtype Prostaglandin E2 receptor EP2 subtype Prostaglandin E2 receptor EP3 subtype Prostaglandin E2 receptor EP4 subtype Prostaglandin F2-alpha receptor Thromboxane A2 receptor Uncharacterized protein	A0A8I3MQM7 A0A8I3MUB8 A0A8I3NCM2 A0A8I3NNN1 A0A8I3P5Y8 Q45FN0 Q9BGL8 Q9TU16 Q9XT82	PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR TBXA2R	Canis familiaris (dog)
FGFRL1 modulation of FGFR1 signaling	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor like 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Sprouty related EVH1 domain containing 1 Sprouty-related, EVH1 domain-containing protein 2 Uncharacterized protein	A0A0B4J199 A0A7U3JWB8 A0A8I3MIK8 A0A8I3MP09 A0A8I3MXL0 A0A8I3NHF3 A0A8I3NSU7 A0A8I3NYK3 A0A8I3PJY6 A0A8I3PWQ1 A0A8I3S5D3 A0A8I3SAY5 J9P3I7 Q20FD0	FGF10 FGF17 FGF18 FGF22 FGF23 FGF3 FGF3A FGF4 FGF5 FGF7A FGF8 FGF8B FGFRL1 SPRED1 SPRED2	Canis familiaris (dog)
Asparagine N-linked glycosylation	Asialoglycoprotein receptor 1 Asialoglycoprotein receptor 2 Beta-1,4-N-acetyl-galactosaminyltransferase 2 Uromodulin	A0A8I3NAX8 A0A8I3NFY5 A0A8I3P3P6 A0A8I3PA45	ASGR1 ASGR2 B4GALNT2 UMOD	Canis familiaris (dog)
Synthesis of 5-eicosatetraenoic acids	Arachidonate 5-lipoxygenase-activating protein Arachidonate 5-lipoxygenase Leukotriene C4 synthase Paraoxonase 3 Paraoxonase Paraoxonase	A0A8I3MWD6 A0A8I3PAM3 A0A8I3PDD9 A0A8I3PDF6 A0A8I3PDS2 A0A8I3SA30	ALOX5 ALOX5AP LTC4S PON1 PON2 PON3	Canis familiaris (dog)
Activation of Matrix Metalloproteinases	72 kDa type IV collagenase Cathepsin G Chymase Chymotrypsinogen 2 Collagen type XVIII alpha 1 chain Collagenase 3 Elastase, neutrophil expressed Kallikrein 1 Kallikrein B1 Kallikrein-related peptidase 2 Matrix metallopeptidase 11 Matrix metallopeptidase 15 Matrix metallopeptidase 16 Matrix metallopeptidase 17 Matrix metallopeptidase 24 Matrix metallopeptidase 25 Matrix metallopeptidase 7 Matrix metallopeptidase 8 Matrix metalloproteinase-14 Matrix metalloproteinase-9 Metalloproteinase inhibitor 1 Metalloproteinase inhibitor 2 Peptidase S1 domain-containing protein Plasminogen Procathepsin L SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 Stromelysin-1 Tryptase furin interstitial collagenase trypsin	A0A5K1VKB9 A0A8I3MCQ8 A0A8I3MF27 A0A8I3MGS0 A0A8I3MN73 A0A8I3MND9 A0A8I3MSY3 A0A8I3MWY2 A0A8I3MXC2 A0A8I3N1T9 A0A8I3N597 A0A8I3NK04 A0A8I3NM17 A0A8I3NXG0 A0A8I3P478 A0A8I3P5C4 A0A8I3PD99 A0A8I3PHE2 A0A8I3PMD6 A0A8I3PZ83 A0A8I3Q4H4 A0A8I3RPH1 A0A8I3S0N4 A0A8I3S3N5 P04813 P15944 P21842 Q6Y4Q5 Q8MJD1 Q9GL24 Q9TTY1	CMA1 COL18A1 CTRB CTRB1 CTSG CTSL CTSL1 ELA2 ELANE FURIN KLK1 KLK2 KLKB1 MMP1 MMP11 MMP13 MMP14 MMP15 MMP16 MMP17 MMP2 MMP24 MMP25 MMP3 MMP7 MMP8 MMP9 PLG PRSS2 SPOCK3 TIMP1 TIMP2	Canis familiaris (dog)
IRS-mediated signalling	Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A5F4C2B1 A0A8I3N971 A0A8I3NVW9 A0A8I3PWT3 A0A8I3S0I1 A0A8I3S3N2	IRS1 IRS2 PIK3CA PIK3CB PIK3R1 PIK3R2	Canis familiaris (dog)
Regulation of actin dynamics for phagocytic cup formation	Abl interactor 1 Abl interactor 2 Actin gamma 1 Actin, cytoplasmic 1 Actin-related protein 2/3 complex subunit 3 Actin-related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2/3 complex subunit Actin-related protein 2/3 complex subunit Actin-related protein 2 Actin-related protein 3 Adapter molecule crk Arp2/3 complex 34 kDa subunit Brain-specific angiogenesis inhibitor 1-associated protein 2 CYRIA/CYRIB Rac1 binding domain-containing protein Cell division control protein 42 homolog Cytoplasmic FMR1-interacting protein Cytoplasmic protein Dedicator of cytokinesis 1 Engulfment and cell motility 1 Engulfment and cell motility 2 Fc fragment of IgG receptor Ia Focal adhesion kinase 1 Growth factor receptor bound protein 2 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein LIM domain kinase 1 Low affinity immunoglobulin gamma Fc region receptor III-A Low affinity immunoglobulin gamma Fc region receptor III-A Mitogen-activated protein kinase Mitogen-activated protein kinase Myosin IC Myosin IXB Myosin VA Myosin X Myosin-2 Myosin-9 NCK associated protein 1 like NCK interacting protein with SH3 domain NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Nck-associated protein 1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Vav guanine nucleotide exchange factor 1 Vav guanine nucleotide exchange factor 2 Vav guanine nucleotide exchange factor 3 WAS/WASL interacting protein family member 1 WASP like actin nucleation promoting factor Wiskott-Aldrich syndrome protein family member Wiskott-Aldrich syndrome protein family member Wiskott-Aldrich syndrome protein family member non-specific serine/threonine protein kinase	A0A8I3MFY1 A0A8I3MIN4 A0A8I3MKB3 A0A8I3ML42 A0A8I3MNR2 A0A8I3MPK0 A0A8I3MR78 A0A8I3MV98 A0A8I3MVD4 A0A8I3N156 A0A8I3N1W7 A0A8I3N9N7 A0A8I3N9V3 A0A8I3NA65 A0A8I3NC73 A0A8I3NE73 A0A8I3NEM6 A0A8I3NEW9 A0A8I3NEZ8 A0A8I3NGQ0 A0A8I3NGY2 A0A8I3NH46 A0A8I3NMF7 A0A8I3NMY1 A0A8I3NNZ1 A0A8I3NU35 A0A8I3NVZ2 A0A8I3NWR3 A0A8I3NZ88 A0A8I3NZQ2 A0A8I3P1N5 A0A8I3P2M2 A0A8I3P2N6 A0A8I3P3G0 A0A8I3P3T7 A0A8I3P4X4 A0A8I3P4Y5 A0A8I3P6V2 A0A8I3P7Z3 A0A8I3P8D4 A0A8I3P8Q3 A0A8I3P941 A0A8I3PD67 A0A8I3PDU9 A0A8I3PGP9 A0A8I3PL11 A0A8I3PPQ5 A0A8I3PQA6 A0A8I3PT15 A0A8I3PT69 A0A8I3PTN6 A0A8I3PUA5 A0A8I3PUN5 A0A8I3PUP2 A0A8I3PUS1 A0A8I3PV91 A0A8I3PVB5 A0A8I3PVC4 A0A8I3PVG3 A0A8I3PWK4 A0A8I3PXN0 A0A8I3PXN9 A0A8I3PXQ9 A0A8I3PYF1 A0A8I3PZH0 A0A8I3PZP0 A0A8I3Q1Q8 A0A8I3Q2I4 A0A8I3Q5E2 A0A8I3Q9N2 A0A8I3QBP5 A0A8I3QCV8 A0A8I3QD99 A0A8I3QE86 A0A8I3QF04 A0A8I3QHH1 A0A8I3QQ00 A0A8I3RQD0 A0A8I3RQZ5 A0A8I3RVS9 A0A8I3RXY6 A0A8I3S0G9 A0A8I3S0K3 A0A8I3S4H5 A0A8I3S602 A0A8I3S6D8 A0A8I3S6H5 A0A8I3S9C3 A0A8I3SAS3 A0A8I3SAS7 A0A8I3SAU8 E2RP87 O18840 P60952 P62999 Q076A7	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BTK CD247 CD3G CDC42 CRK CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FCGR1A FCGR2B FCGR3A GRB2 HSP90AA1 HSP90AB1 LIMK1 LOC478984 MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD NF2 PAK1 PTK2 RAC1 SYK VAV1 VAV2 VAV3 WASF1 WASF2 WASF3 WASL WIPF1	Canis familiaris (dog)
Erythrocytes take up oxygen and release carbon dioxide	Ammonium transporter Rh type A Anion exchange protein Aquaporin-1 Carbonic anhydrase Carbonic anhydrase Carbonic anhydrase Globin A2 Globin domain-containing protein	A0A1K0GGH0 A0A8I3MCD6 A0A8I3MZM2 A0A8I3P092 A0A8I3Q3H0 A0A8I3S2I1 Q2Z1P8 Q9N2J4	AQP1 CA1 CA2 CA4 GLNA2 GLNA3 HBQ1 LOC609402 RHAG SLC4A1	Canis familiaris (dog)
Platelet homeostasis	P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor Platelet-activating factor acetylhydrolase	A0A8I3NPN3 A0A8I3NX68 A0A8I3P313 A0A8I3PPB8 A0A8I3PV78 A0A8I3Q0A9 A0A8I3QCF1 A0A8I3S3K0	P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 PAFAH2	Canis familiaris (dog)
VxPx cargo-targeting to cilium	ADP-ribosylation factor ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Cyclic nucleotide gated channel subunit alpha 4 Cyclic nucleotide gated channel subunit beta 1 Cyclic nucleotide-gated olfactory channel Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 5 Exocyst complex component 7 Exocyst complex component 8 Exocyst complex component Sec8 Exocyst complex component Golgi brefeldin A resistant guanine nucleotide exchange factor 1 Polycystin-2 RAB11 family interacting protein 3 RAB3A interacting protein Ras-related protein Rab-11A Ras-related protein Rab-8A Rhodopsin	A0A8I3MLB7 A0A8I3MLZ0 A0A8I3N510 A0A8I3NMX3 A0A8I3NS37 A0A8I3NTX3 A0A8I3NZH4 A0A8I3NZH6 A0A8I3P3F1 A0A8I3PAA1 A0A8I3PH62 A0A8I3PMI1 A0A8I3PN68 A0A8I3PQE3 A0A8I3PZW4 A0A8I3QBX3 A0A8I3QE57 A0A8I3S0B6 P61007 P62490	ARF4 ASAP1 CNGA2 CNGA4 CNGB1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GBF1 MEL PKD2 RAB11 RAB11A RAB11FIP3 RAB3IP RAB8 RAB8A RHO	Canis familiaris (dog)
Cargo recognition for clathrin-mediated endocytosis	AP complex subunit beta AP-2 complex subunit alpha AP-2 complex subunit alpha AP-2 complex subunit mu AP-2 complex subunit sigma AP2 associated kinase 1 Adaptin ear-binding coat-associated protein 1 Apolipoprotein B ArfGAP with FG repeats 1 Arginine vasopressin Beta-2 adrenergic receptor Beta-arrestin-1 Beta-arrestin-2 COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 3 COP9 signalosome complex subunit 6 COP9 signalosome complex subunit 8 COP9 signalosome subunit 5 COP9 signalosome subunit 7A COP9 signalosome subunit 7B Cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor protein Clathrin heavy chain Clathrin heavy chain Clathrin light chain Clathrin light chain Cystic fibrosis transmembrane conductance regulator Cystic fibrosis transmembrane conductance regulator DAB adaptor protein 2 Dishevelled segment polarity protein 2 E3 ubiquitin-protein ligase CBL EGF-like domain-containing protein Endophilin-A2 Epidermal growth factor receptor pathway substrate 15 like 1 Epidermal growth factor receptor pathway substrate 15 Epiregulin Epsin 2 F-BAR domain only protein 2 FCH and mu domain containing endocytic adaptor 1 Frizzled-4 G protein pathway suppressor 1 G protein-coupled receptor kinase G protein-coupled receptor kinase Growth factor receptor bound protein 2 Hepatocyte growth factor-regulated tyrosine kinase substrate Interleukin-7 receptor subunit alpha Intersectin 1 Intersectin 2 KIAA0319 LDL receptor related protein 2 Low density lipoprotein receptor adaptor protein 1 Low-density lipoprotein receptor Mannose-6-phosphate receptor, cation dependent Muscarinic acetylcholine receptor NEDD8 Phosphatidylinositol binding clathrin assembly protein Pro-epidermal growth factor Proheparin-binding EGF-like growth factor Protein Wnt RALBP1 associated Eps domain containing 1 RALBP1 associated Eps domain containing 2 Receptor protein-tyrosine kinase SH3 domain containing GRB2 like 2, endophilin A1 SH3 domain containing kinase binding protein 1 Scavenger receptor class B member 2 Signal transducing adaptor molecule 2 Signal transducing adaptor molecule Solute carrier family 18 member A3 Solute carrier family 2 member 8 Stonin-1 Stonin-2 Substance-P receptor Synaptosome associated protein 91 Synaptotagmin 11 Synaptotagmin 8 Synaptotagmin Synaptotagmin T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Torsin Torsin Trans-golgi network protein 2 Type-1 angiotensin II receptor Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Vasopressin V2 receptor Vesicle associated membrane protein 4 Vesicle-associated membrane protein 2 Vesicle-associated membrane protein 3 Vesicle-associated membrane protein 7 Vesicle-associated membrane protein 8	A0A8I3MAW6 A0A8I3MBG9 A0A8I3MBU4 A0A8I3MFY1 A0A8I3MJ11 A0A8I3MJ91 A0A8I3MMN5 A0A8I3MQ56 A0A8I3MT64 A0A8I3MT80 A0A8I3MZG1 A0A8I3MZL3 A0A8I3N0H9 A0A8I3N1F4 A0A8I3N2C0 A0A8I3N2E5 A0A8I3N2P0 A0A8I3N399 A0A8I3N7P9 A0A8I3N8L8 A0A8I3N8T5 A0A8I3N970 A0A8I3NCI2 A0A8I3ND55 A0A8I3NE91 A0A8I3NF22 A0A8I3NFB9 A0A8I3NGD3 A0A8I3NH32 A0A8I3NHL8 A0A8I3NHV2 A0A8I3NIR2 A0A8I3NKR3 A0A8I3NLC1 A0A8I3NPI2 A0A8I3NRM5 A0A8I3NS16 A0A8I3NTR3 A0A8I3NXQ1 A0A8I3NZX3 A0A8I3P087 A0A8I3P562 A0A8I3P6R3 A0A8I3P953 A0A8I3P9Q7 A0A8I3PCP2 A0A8I3PE10 A0A8I3PFJ2 A0A8I3PGA9 A0A8I3PGB9 A0A8I3PI71 A0A8I3PK82 A0A8I3PKW5 A0A8I3PMU1 A0A8I3PMU8 A0A8I3PP11 A0A8I3PPD9 A0A8I3PQE6 A0A8I3PRS1 A0A8I3PSX7 A0A8I3PT69 A0A8I3PV70 A0A8I3PVK3 A0A8I3PVM0 A0A8I3PWA8 A0A8I3Q314 A0A8I3Q374 A0A8I3Q3J5 A0A8I3Q545 A0A8I3Q5C2 A0A8I3Q5L9 A0A8I3QYD0 A0A8I3QZA5 A0A8I3RP69 A0A8I3RPS3 A0A8I3RR45 A0A8I3RTD0 A0A8I3RU23 A0A8I3RUS6 A0A8I3RV18 A0A8I3RV68 A0A8I3RYJ5 A0A8I3RZ76 A0A8I3RZF8 A0A8I3S1H6 A0A8I3S360 A0A8I3S4D1 A0A8I3S565 A0A8I3S6J8 A0A8I3S7E5 A0A8I3S9K7 A0A8I3SAF2 A0A8I3SBB3 B1H0W0 F1PHV6 P33705 P63050 Q5DUB3 Q5U820	AAK1 ABCC7 ADRB2 AGFG1 AGTR1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOB AREG ARRB1 ARRB2 AVP AVPR2 BTC CBL CD3D CD3G CD4 CFTR CHRM2 CI-MPR/IGF2R CLTA CLTB CLTC CLTCL1 COPS2 COPS3 COPS5 COPS6 COPS7A COPS7B COPS8 DAB2 DVL2 EGF EGFR EPGN EPN1 EPN2 EPS15 EPS15L1 EREG FCHO1 FCHO2 FZD4 GPS1 GRB2 GRK2 GRK3 HBEGF HGS IGF2R IL7R ITSN2 KIAA0319 LDLR LDLRAP1 LOC102156511 LOC119867035 LRP2 M6PR NECAP1 NECAP2 NEDD8 PICALM REPS2 RPS27A SCARB2 SH3GL1 SH3GL2 SH3KBP1 SLC18A3 SLC2A8 SNAP91 STAM STAM2 STON1 STON2 SYT1 SYT11 SYT2 SYT8 TACR1 TGFA TGOLN2 TOR1A TOR1B UBA52 UBB UBC UBCEP2 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 WNT5A	Canis familiaris (dog)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Cartilage intermediate layer protein Insulin-like growth factor I Insulin-like growth factor II Tyrosine-protein kinase receptor	A0A8I3NI15 A0A8I3RQ77 A0A8I3S512 P33712	CILP IGF1 IGF1R IGF2 IGFIA	Canis familiaris (dog)
GPVI-mediated activation cascade	3-phosphoinositide-dependent protein kinase 1 C-type lectin domain-containing protein Cell division control protein 42 homolog High affinity immunoglobulin epsilon receptor subunit gamma Lymphocyte cytosolic protein 2 Megakaryocyte and platelet inhibitory receptor G6b Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide 3-kinase regulatory subunit 5 Phosphoinositide phospholipase C Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 Phosphoinositide-3-kinase regulatory subunit 6 Podoplanin Rac family small GTPase 2 Ras homolog family member B Ras homolog family member G Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 Transforming protein RhoA Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Tyrosine-protein phosphatase non-receptor type Uncharacterized protein Uncharacterized protein Vav guanine nucleotide exchange factor 1 Vav guanine nucleotide exchange factor 2 Vav guanine nucleotide exchange factor 3 phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A5F4C2B1 A0A8I3MGV8 A0A8I3MHV4 A0A8I3MMK3 A0A8I3MQX7 A0A8I3MY22 A0A8I3N060 A0A8I3N5M3 A0A8I3N971 A0A8I3NA65 A0A8I3NAC6 A0A8I3NC73 A0A8I3NEZ8 A0A8I3NH46 A0A8I3NHC2 A0A8I3NIT3 A0A8I3NZG2 A0A8I3P075 A0A8I3P3G0 A0A8I3P3X1 A0A8I3P519 A0A8I3PMT9 A0A8I3PUN0 A0A8I3PVV6 A0A8I3PWC6 A0A8I3PWT3 A0A8I3PY16 A0A8I3QSK6 A0A8I3S3N2 A0A8I3S601 P60952 P62999 Q95152	CDC42 CLEC1B FCER1G FYN GP40 GP6 LAT LCK LCP2 LOC100856339 LYN MPIG6B PDPK1 PDPN PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R5 PIK3R6 PLCG2 PTPN11 PTPN6 RAC1 RAC2 RHOA RHOB RHOG SYK VAV1 VAV2 VAV3	Canis familiaris (dog)
FRS-mediated FGFR3 signaling	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Multifunctional fusion protein SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type Uncharacterized protein small monomeric GTPase	A0A0B4J199 A0A7U3JWB8 A0A8I3MIK8 A0A8I3NHF3 A0A8I3NM39 A0A8I3NS74 A0A8I3NTD6 A0A8I3NV07 A0A8I3P4L9 A0A8I3PJY6 A0A8I3PMT9 A0A8I3PSP7 A0A8I3PT69 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3SAY5 J9P0B3 J9P3I7 J9P8K0 Q20FD0	FGF1 FGF16 FGF17 FGF18 FGF20 FGF23 FGF3A FGF4 FGF4B FGF4C FGF5 FGF7A FGF8 FGF8B FGF9 FGFR3 FRS2 FRS3 GRB2 HRAS KRAS NRAS PTPN11 SOS1	Canis familiaris (dog)
FGFR2b ligand binding and activation	Fibroblast growth factor 7 Fibroblast growth factor binding protein 1 Fibroblast growth factor binding protein 3 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Multifunctional fusion protein	A0A8I3MH10 A0A8I3MP09 A0A8I3NHF3 A0A8I3NSU7 A0A8I3NV07 A0A8I3NYK3 A0A8I3P6D2 A0A8I3Q445 P79150	FGF1 FGF10 FGF22 FGF3 FGF7 FGFBP1 FGFBP3 FGFR2 KGF	Canis familiaris (dog)
Ion channel transport	ATPase H+ transporting V0 subunit b ATPase H+ transporting V1 subunit B1 ATPase H+ transporting V1 subunit E2 ATPase H+ transporting V1 subunit H ATPase H+ transporting accessory protein 1 H(+)-transporting two-sector ATPase V-type proton ATPase proteolipid subunit V-type proton ATPase subunit C V-type proton ATPase subunit C V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit F V-type proton ATPase subunit G V-type proton ATPase subunit G V-type proton ATPase subunit a V-type proton ATPase subunit a V-type proton ATPase subunit a V-type proton ATPase subunit a V-type proton ATPase subunit V-type proton ATPase subunit V-type proton ATPase subunit Vacuolar proton pump subunit B	A0A8I3MGE7 A0A8I3MUZ6 A0A8I3MZT8 A0A8I3NAA2 A0A8I3NAS2 A0A8I3ND81 A0A8I3NF98 A0A8I3NSM9 A0A8I3P989 A0A8I3PF77 A0A8I3PSZ6 A0A8I3PTB0 A0A8I3PWA9 A0A8I3PYI5 A0A8I3Q2N9 A0A8I3Q434 A0A8I3QBE3 A0A8I3QKG1 A0A8I3QRA4 A0A8I3RRR2 A0A8I3RWI5 A0A8I3SB94	ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G3 ATP6V1H TCIRG1	Canis familiaris (dog)
DAP12 signaling	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Beta-2-microglobulin C-type lectin domain-containing protein C-type lectin domain-containing protein GRB2 related adaptor protein 2 GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Immunoglobulin subtype domain-containing protein Lymphocyte cytosolic protein 2 NKG2-D type II integral membrane protein Natural killer cells antigen CD94 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide phospholipase C Phosphoinositide-3-kinase regulatory subunit 2 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 TYRO protein tyrosine kinase-binding protein Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Vav guanine nucleotide exchange factor 2 Vav guanine nucleotide exchange factor 3 phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase small monomeric GTPase	A0A5F4C2B1 A0A8I3MDD5 A0A8I3MGV8 A0A8I3MMK3 A0A8I3N971 A0A8I3NAC6 A0A8I3NC73 A0A8I3NEZ8 A0A8I3NH46 A0A8I3NUU1 A0A8I3NVH5 A0A8I3NZG2 A0A8I3P3G0 A0A8I3P3X1 A0A8I3P6Q8 A0A8I3P7Z3 A0A8I3PNL2 A0A8I3PNS2 A0A8I3PSP7 A0A8I3PT69 A0A8I3PWT3 A0A8I3PWV8 A0A8I3PXH7 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3S3N2 A0A8I3SCI7 P62999 Q38HS3	B2M BTK CD94 FYN GRAP2 GRB2 HRAS KLRD1 KLRK1 KRAS LAT LCK LCP2 LOC119863908 LOC119866326 NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PLCG2 RAC1 SHC1 SOS1 SYK TYROBP VAV2 VAV3	Canis familiaris (dog)

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