GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **151 - 175** of **268** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲	Organism	GlyTouCan ID
Role of phospholipids in phagocytosis	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma 5'-3' exonuclease PLD3 Fc fragment of IgG receptor Ia Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Low affinity immunoglobulin gamma Fc region receptor III-A Low affinity immunoglobulin gamma Fc region receptor III-A Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide phospholipase C Phosphoinositide-3-kinase regulatory subunit 2 Phospholipase Phospholipase Phospholipid phosphatase 4 Protein kinase C delta type Protein kinase C epsilon type T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phospholipase A2	A0A5F4C2B1 A0A8I3MFY1 A0A8I3MMY6 A0A8I3MQR0 A0A8I3MV98 A0A8I3N971 A0A8I3NEM6 A0A8I3NWR3 A0A8I3NYY2 A0A8I3NZG2 A0A8I3P1N5 A0A8I3P2M2 A0A8I3P2N6 A0A8I3P3G0 A0A8I3P3T7 A0A8I3P4X4 A0A8I3P4Y5 A0A8I3P6V2 A0A8I3P941 A0A8I3PAT0 A0A8I3PCM7 A0A8I3PD67 A0A8I3PDU9 A0A8I3PL11 A0A8I3PQA6 A0A8I3PT15 A0A8I3PTN6 A0A8I3PUA5 A0A8I3PUN5 A0A8I3PUP2 A0A8I3PUS1 A0A8I3PV91 A0A8I3PVB5 A0A8I3PVC4 A0A8I3PVG3 A0A8I3PWK4 A0A8I3PWT0 A0A8I3PWT3 A0A8I3PXN9 A0A8I3PXQ9 A0A8I3PYF1 A0A8I3PZJ7 A0A8I3Q258 A0A8I3Q590 A0A8I3Q5E2 A0A8I3QCV8 A0A8I3QD99 A0A8I3QE86 A0A8I3QF04 A0A8I3QHH1 A0A8I3QQ00 A0A8I3S0G9 A0A8I3S0K3 A0A8I3S3N2 A0A8I3S6H5 A0A8I3S9C3 A0A8I3SAS3 A0A8I3SAS7 A0A8I3SCI7 E2RP87	CD247 CD3G FCGR1A FCGR2B FCGR3A LOC478984 PIK3CA PIK3CB PIK3R1 PIK3R2 PLA2G6 PLCG1 PLCG2 PLD1 PLD2 PLD3 PLD4 PLPP4 PLPP5 PRKCD PRKCE SYK	Canis familiaris (dog)
TNFs bind their physiological receptors	CD27 molecule CD70 molecule EDAR associated via death domain Ectodysplasin A receptor Ectodysplasin A LIGHT Lymphotoxin-alpha Migration and invasion inhibitory protein TNF family profile domain-containing protein TNF receptor superfamily member 14 TNF receptor superfamily member 17 TNF receptor superfamily member 18 TNF receptor superfamily member 1B TNF receptor superfamily member 6b TNF receptor superfamily member 9 TNF superfamily member 13 TNF superfamily member 13b TNF superfamily member 18 TNF superfamily member 4 TNF superfamily member 8 TNFR-Cys domain-containing protein Tumor necrosis factor ligand superfamily member Tumor necrosis factor receptor superfamily member 11B Uncharacterized protein Uncharacterized protein	A0A0U5JAK9 A0A8I3MEA7 A0A8I3MKG7 A0A8I3MM10 A0A8I3MPQ0 A0A8I3N568 A0A8I3NB07 A0A8I3NFC1 A0A8I3NGJ3 A0A8I3NJU2 A0A8I3NZX5 A0A8I3P405 A0A8I3PKB9 A0A8I3PLK9 A0A8I3PMM9 A0A8I3Q3L1 A0A8I3Q7M4 A0A8I3QDG0 A0A8I3S9F2 E2R8I1 E2RP79 J9JHM5 J9P753 Q58P77 Q5WR07	CD27 CD70 EDA EDAR EDARADD LTA MIIP TNFB TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF6B TNFRSF9 TNFSF1 TNFSF11 TNFSF13 TNFSF13B TNFSF14 TNFSF18 TNFSF4 TNFSF8 TNLG1D TNLG2A TNLG2B TNLG3A TNLG7A	Canis familiaris (dog)
Hyaluronan uptake and degradation	Beta-glucuronidase Beta-hexosaminidase Beta-hexosaminidase CD44 antigen Calcineurin B homologous protein 1 Hyaluronan mediated motility receptor Hyaluronidase Lymphatic vessel endothelial hyaluronan receptor 1 Sodium/hydrogen exchanger Stabilin 2	A0A8I3MHZ0 A0A8I3MY15 A0A8I3NBX1 A0A8I3NDU0 A0A8I3NYL9 A0A8I3PCF8 A0A8I3PI48 A0A8I3PNW9 A0A8I3Q0H4 A0A8I3RW87	CD44 CHP1 GUSB HEXA HEXB HMMR HYAL1 LYVE1 SLC9A1 STAB2	Canis familiaris (dog)	G35674CY
CD22 mediated BCR regulation	B-cell antigen receptor complex-associated protein alpha chain B-cell receptor CD22 CD79a molecule CD79b molecule Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein	A0A8I3MIL9 A0A8I3MUW4 A0A8I3NVL7 A0A8I3NWR3 A0A8I3P1N5 A0A8I3P2M2 A0A8I3P3T7 A0A8I3P4X4 A0A8I3P4Y5 A0A8I3P501 A0A8I3P6V2 A0A8I3P941 A0A8I3PD67 A0A8I3PDA6 A0A8I3PDU9 A0A8I3PL11 A0A8I3PQA6 A0A8I3PT15 A0A8I3PTN6 A0A8I3PUA5 A0A8I3PUN0 A0A8I3PUN5 A0A8I3PUP2 A0A8I3PUS1 A0A8I3PV91 A0A8I3PVB5 A0A8I3PVC4 A0A8I3PVG3 A0A8I3PWC6 A0A8I3PWK4 A0A8I3PXN9 A0A8I3PXQ9 A0A8I3PYF1 A0A8I3Q5E2 A0A8I3QCV8 A0A8I3QD99 A0A8I3QE86 A0A8I3QF04 A0A8I3S0G9 A0A8I3S0K3 A0A8I3S6H5 A0A8I3S9C3 A0A8I3SAS3 A0A8I3SAS7 P0CAN6	CD79A CD79B IGHM LYN MAG PTPN6	Canis familiaris (dog)
GPVI-mediated activation cascade	3-phosphoinositide-dependent protein kinase 1 C-type lectin domain-containing protein Cell division control protein 42 homolog High affinity immunoglobulin epsilon receptor subunit gamma Lymphocyte cytosolic protein 2 Megakaryocyte and platelet inhibitory receptor G6b Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide 3-kinase regulatory subunit 5 Phosphoinositide phospholipase C Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 Phosphoinositide-3-kinase regulatory subunit 6 Podoplanin Rac family small GTPase 2 Ras homolog family member B Ras homolog family member G Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 Transforming protein RhoA Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Tyrosine-protein phosphatase non-receptor type Uncharacterized protein Uncharacterized protein Vav guanine nucleotide exchange factor 1 Vav guanine nucleotide exchange factor 2 Vav guanine nucleotide exchange factor 3 phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A5F4C2B1 A0A8I3MGV8 A0A8I3MHV4 A0A8I3MMK3 A0A8I3MQX7 A0A8I3MY22 A0A8I3N060 A0A8I3N5M3 A0A8I3N971 A0A8I3NA65 A0A8I3NAC6 A0A8I3NC73 A0A8I3NEZ8 A0A8I3NH46 A0A8I3NHC2 A0A8I3NIT3 A0A8I3NZG2 A0A8I3P075 A0A8I3P3G0 A0A8I3P3X1 A0A8I3P519 A0A8I3PMT9 A0A8I3PUN0 A0A8I3PVV6 A0A8I3PWC6 A0A8I3PWT3 A0A8I3PY16 A0A8I3QSK6 A0A8I3S3N2 A0A8I3S601 P60952 P62999 Q95152	CDC42 CLEC1B FCER1G FYN GP40 GP6 LAT LCK LCP2 LOC100856339 LYN MPIG6B PDPK1 PDPN PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R5 PIK3R6 PLCG2 PTPN11 PTPN6 RAC1 RAC2 RHOA RHOB RHOG SYK VAV1 VAV2 VAV3	Canis familiaris (dog)
Voltage gated Potassium channels	Potassium voltage-gated channel modifier subfamily F member 1 Potassium voltage-gated channel modifier subfamily G member 1 Potassium voltage-gated channel modifier subfamily G member 3 Potassium voltage-gated channel modifier subfamily G member 4 Potassium voltage-gated channel modifier subfamily S member 2 Potassium voltage-gated channel modifier subfamily S member 3 Potassium voltage-gated channel modifier subfamily V member 2 Potassium voltage-gated channel subfamily A member 10 Potassium voltage-gated channel subfamily A member 1 Potassium voltage-gated channel subfamily A member 2 Potassium voltage-gated channel subfamily A member 4 Potassium voltage-gated channel subfamily A member 5 Potassium voltage-gated channel subfamily A member 6 Potassium voltage-gated channel subfamily A member 7 Potassium voltage-gated channel subfamily A regulatory beta subunit 3 Potassium voltage-gated channel subfamily B member 1 Potassium voltage-gated channel subfamily B member 2 Potassium voltage-gated channel subfamily C member 1 Potassium voltage-gated channel subfamily C member 2 Potassium voltage-gated channel subfamily C member 3 Potassium voltage-gated channel subfamily C member 4 Potassium voltage-gated channel subfamily D member 1 Potassium voltage-gated channel subfamily D member 2 Potassium voltage-gated channel subfamily D member 3 Potassium voltage-gated channel subfamily H member 1 Potassium voltage-gated channel subfamily H member 2 Potassium voltage-gated channel subfamily H member 3 Potassium voltage-gated channel subfamily H member 4 Potassium voltage-gated channel subfamily H member 5 Potassium voltage-gated channel subfamily H member 6 Potassium voltage-gated channel subfamily H member 7 Potassium voltage-gated channel subfamily H member 8 Potassium voltage-gated channel subfamily Q member 4 Potassium voltage-gated channel subfamily Q member 5 Potassium voltage-gated channel subfamily S member 1 Potassium voltage-gated channel subfamily V member 1 Uncharacterized protein Voltage-gated potassium channel subunit beta-1 Voltage-gated potassium channel subunit beta-1	A0A8I3MEP9 A0A8I3MI33 A0A8I3MKX7 A0A8I3MLJ0 A0A8I3MVA0 A0A8I3MXL4 A0A8I3N7D5 A0A8I3NJP1 A0A8I3NJX7 A0A8I3NQD6 A0A8I3NTA2 A0A8I3NTD2 A0A8I3NX36 A0A8I3NXU7 A0A8I3P2T7 A0A8I3P439 A0A8I3PC38 A0A8I3PCB8 A0A8I3PHK5 A0A8I3PNB9 A0A8I3PQT7 A0A8I3PSN3 A0A8I3PT46 A0A8I3PV26 A0A8I3PWG2 A0A8I3PX68 A0A8I3PYY4 A0A8I3Q626 A0A8I3QAI0 A0A8I3RSP4 A0A8I3RV31 A0A8I3RXY5 A0A8I3S677 A0A8I3S7S4 A0A8I3SCN1 F1PBP9 F1PKN8 I0BWQ7 Q9TSZ3	CERG ERG KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNAB1 KCNAB2 KCNAB3 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2	Canis familiaris (dog)
Phase 3 - rapid repolarisation	Potassium voltage-gated channel subfamily A member 5 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily E regulatory subunit 3 Potassium voltage-gated channel subfamily E regulatory subunit 5 Potassium voltage-gated channel subfamily H member 2 Uncharacterized protein	A0A8I3MYQ7 A0A8I3P4I4 A0A8I3PKK9 A0A8I3PME7 A0A8I3PYI8 A0A8I3SCN1 Q9TSZ3	CERG ERG KCNA5 KCNE2 KCNE3 KCNE4 KCNE5 KCNH2	Canis familiaris (dog)
Thyroxine biosynthesis	Dual oxidase 1 Glycoprotein hormones alpha chain Iodotyrosine deiodinase 1 NAD(P)H oxidase (H2O2-forming) Solute carrier family 5 member 5 Thyroid peroxidase Thyrotropin subunit beta	A0A0F7RPW1 A0A8I3P5E5 A0A8I3PAJ8 A0A8I3PWH8 A0A8I3Q1X1 A0A8I3QSW1 Q9MZF4	CGA DUOX1 DUOX2 GPA1 IYD SLC5A5 THOX1 TPO TSHB	Canis familiaris (dog)
Hormone ligand-binding receptors	Follicle-stimulating hormone receptor Follitropin subunit beta Glycoprotein hormone subunit beta 5 Glycoprotein hormones alpha chain Gonadotropin-releasing hormone receptor Progonadoliberin Thyrotropin receptor Thyrotropin subunit beta Uncharacterized protein	A0A0F7RPW1 A0A0F7RQS3 A0A8I3MZ56 A0A8I3N8M9 A0A8I3PVK9 A0A8I3Q1X1 A0A8I3RXY8 E2RJZ8 P14763	CGA FSHB FSHR GNRH1 GNRHR GPA1 GPB5 GPHA2 GPHB5 TSHB TSHR	Canis familiaris (dog)
Signaling by SCF-KIT	Chymase GRB2 associated binding protein 2 GRB2 related adaptor protein 2 GRB2 related adaptor protein GTPase HRas GTPase NRas Growth factor receptor bound protein 10 Growth factor receptor bound protein 2 Growth factor receptor bound protein 7 Kit ligand Mast/stem cell growth factor receptor Kit Matrix metalloproteinase-9 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 Protein kinase C Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Serine/threonine-protein kinase Chk1 Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Vav guanine nucleotide exchange factor 1 phosphatidylinositol-4,5-bisphosphate 3-kinase protein-tyrosine-phosphatase small monomeric GTPase	A0A5F4C2B1 A0A8I3MAK5 A0A8I3MKV4 A0A8I3ML64 A0A8I3MW46 A0A8I3N971 A0A8I3N974 A0A8I3N9M7 A0A8I3NA65 A0A8I3NAC6 A0A8I3NB92 A0A8I3NBK6 A0A8I3NBM3 A0A8I3NH46 A0A8I3NID0 A0A8I3NVH4 A0A8I3P3X1 A0A8I3P478 A0A8I3P519 A0A8I3P5U0 A0A8I3P6Q8 A0A8I3PMT9 A0A8I3PSA1 A0A8I3PSP7 A0A8I3PT69 A0A8I3PUN0 A0A8I3PUQ8 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3RV66 A0A8I3RVE7 A0A8I3S3D9 A0A8I3S3N2 A0A8I3SBF9 O97799 P21842 P62999 Q06220	CHEK1 CMA1 FER FES FYN GAB2 GRAP GRAP2 GRB10 GRB2 GRB7 HRAS JAK2 KIT KITLG KRAS LCK LOC100856339 LYN MGF MMP9 NRAS PIK3CA PIK3R1 PIK3R2 PRKCA PTPN11 PTPRU RAC1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B TEC VAV1 YES1	Canis familiaris (dog)
Digestion of dietary carbohydrate	Alpha-amylase Lactase Maltase-glucoamylase Sucrase-isomaltase chitinase	A0A8I3MKS5 A0A8I3NDB4 A0A8I3P4Z5 A0A8I3QYQ3 J9PAL7	CHIA LCT LOC119879923 LOC119881526 MGAM SI	Canis familiaris (dog)	G58161NS G74621DY G93924TT G96370VA
Reactions specific to the complex N-glycan synthesis pathway	Alpha-(1,6)-fucosyltransferase Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Alpha-L-fucosidase Alpha-mannosidase Alpha-mannosidase Carbohydrate sulfotransferase Fucosyltransferase	A0A8I3MHX5 A0A8I3MIH1 A0A8I3NLH2 A0A8I3NVI8 A0A8I3P218 A0A8I3RQC8 A0A8I3RTC2	CHST10 FUCA1 FUT5 FUT8 MAN2A1 MAN2A2 MGAT2	Canis familiaris (dog)	G70323CJ G82576YO
Interleukin-1 signaling	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin 1 E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase pellino homolog E3 ubiquitin-protein ligase pellino homolog IkappaB kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha Interleukin 1 receptor accessory protein Interleukin 1 receptor associated kinase 3 Interleukin 1 receptor type 1 Interleukin 1 receptor type 2 Interleukin-1 receptor antagonist protein Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-associated kinase-like 2 Interleukin-1 Mitogen-activated protein kinase kinase kinase 3 Mitogen-activated protein kinase kinase kinase 7 Multifunctional fusion protein Myeloid differentiation primary response protein MyD88 NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Pellino E3 ubiquitin protein ligase family member 3 Proteasome 20S subunit alpha 3 Proteasome 26S subunit, ATPase 1 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 10 Proteasome 26S subunit, non-ATPase 12 Proteasome 26S subunit, non-ATPase 14 Proteasome 26S subunit, non-ATPase 3 Proteasome 26S subunit, non-ATPase 7 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit beta type-8 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta RELA proto-oncogene, NF-kB subunit Ring-box 1 S-phase kinase-associated protein 1 Sequestosome 1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TNF receptor-associated factor 6 Toll interacting protein Ubiquitin B Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein Uncharacterized protein Uncharacterized protein mitogen-activated protein kinase kinase non-specific serine/threonine protein kinase	A0A8I3MKL4 A0A8I3MMN5 A0A8I3MNI0 A0A8I3MR89 A0A8I3MU16 A0A8I3MUE2 A0A8I3N0P1 A0A8I3N165 A0A8I3N2A1 A0A8I3N3S4 A0A8I3N4F2 A0A8I3N5F1 A0A8I3N5F6 A0A8I3N7L6 A0A8I3N952 A0A8I3N9G3 A0A8I3NBF5 A0A8I3NFB9 A0A8I3NH42 A0A8I3NHA9 A0A8I3NJ31 A0A8I3NMB6 A0A8I3NN65 A0A8I3NNJ9 A0A8I3NP41 A0A8I3NP66 A0A8I3NPR4 A0A8I3NPT2 A0A8I3NPX1 A0A8I3NUC6 A0A8I3NUK8 A0A8I3NVB6 A0A8I3NW81 A0A8I3NXK9 A0A8I3NXW3 A0A8I3NZN1 A0A8I3P046 A0A8I3P2V4 A0A8I3P3H3 A0A8I3P499 A0A8I3P4Z1 A0A8I3P6I7 A0A8I3P6M2 A0A8I3PB85 A0A8I3PBB2 A0A8I3PCE5 A0A8I3PCT4 A0A8I3PDR8 A0A8I3PF55 A0A8I3PF76 A0A8I3PGC5 A0A8I3PJH9 A0A8I3PJW0 A0A8I3PKH4 A0A8I3PLL0 A0A8I3PMA2 A0A8I3PN81 A0A8I3PV99 A0A8I3PZT2 A0A8I3Q059 A0A8I3Q209 A0A8I3QV78 A0A8I3QYD0 A0A8I3RRR7 A0A8I3RT39 A0A8I3RUU8 A0A8I3RXV3 A0A8I3RY59 A0A8I3RZF7 A0A8I3RZP6 A0A8I3S1Z6 A0A8I3S6C6 A0A8I3S6Q5 A0A8I3S792 E2R2I5 P63050 Q5W412 Q5W416 Q6F3J0 Q9BEH0	CHUK CUL1 IKBKB IKBKG IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IRAK1 IRAK2 IRAK3 IRAK4 LOC100686569 LOC100687259 LOC119881719 LOC610717 MAP2K6 MAP3K3 MAP3K7 MYD88 NFKB1 NFKBIA PELI1 PELI2 PELI3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RBX1 RELA RPS27A SKP1 SQSTM1 TAB1 TAB2 TAB3 TOLLIP TRAF6 UBA52 UBB UBC UBCEP2 UBE2N	Canis familiaris (dog)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Cartilage intermediate layer protein Insulin-like growth factor I Insulin-like growth factor II Tyrosine-protein kinase receptor	A0A8I3NI15 A0A8I3RQ77 A0A8I3S512 P33712	CILP IGF1 IGF1R IGF2 IGFIA	Canis familiaris (dog)
Creatine metabolism	Creatine kinase B-type Creatine kinase M-type Creatine kinase S-type, mitochondrial Creatine kinase U-type, mitochondrial Glycine amidinotransferase Sodium- and chloride-dependent betaine transporter Transporter Transporter Transporter guanidinoacetate N-methyltransferase	A0A8I3N7M6 A0A8I3NN25 A0A8I3PNS0 A0A8I3QPK3 A0A8I3RV00 A0A8I3S431 A0A8I3S958 P05123 P05124 P27799	CKB CKM CKMT2 GAMT GATM LOC478277 SLC6A11 SLC6A12 SLC6A7 SLC6A8	Canis familiaris (dog)
IL-6-type cytokine receptor ligand interactions	Cardiotrophin 1 Cardiotrophin like cytokine factor 1 Ciliary neurotrophic factor receptor subunit alpha Cytokine receptor like factor 1 Interleukin 11 receptor subunit alpha Interleukin 11 Interleukin 31 receptor A Interleukin 31 Interleukin 6 cytokine family signal transducer LIF receptor subunit alpha Leukemia inhibitory factor receptor Leukemia inhibitory factor Oncostatin M receptor Oncostatin M Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase	A0A8I3MI11 A0A8I3MM33 A0A8I3MMT5 A0A8I3NB19 A0A8I3NVH4 A0A8I3PYY3 A0A8I3Q5M1 A0A8I3Q5S6 A0A8I3QPC9 A0A8I3RS40 A0A8I3RZV3 A0A8I3S4K2 A0A8I3S524 A0A8I3S6B0 C7G0W1 Q5XNR9 Q71DR4	CLCF1 CNTFR CRLF1 CTF1 IL-31 IL11 IL11RA IL31 IL31RA IL6ST JAK1 JAK2 LIF LIFR OSM OSMR TYK2	Canis familiaris (dog)
Activation of Matrix Metalloproteinases	72 kDa type IV collagenase Cathepsin G Chymase Chymotrypsinogen 2 Collagen type XVIII alpha 1 chain Collagenase 3 Elastase, neutrophil expressed Kallikrein 1 Kallikrein B1 Kallikrein-related peptidase 2 Matrix metallopeptidase 11 Matrix metallopeptidase 15 Matrix metallopeptidase 16 Matrix metallopeptidase 17 Matrix metallopeptidase 24 Matrix metallopeptidase 25 Matrix metallopeptidase 7 Matrix metallopeptidase 8 Matrix metalloproteinase-14 Matrix metalloproteinase-9 Metalloproteinase inhibitor 1 Metalloproteinase inhibitor 2 Peptidase S1 domain-containing protein Plasminogen Procathepsin L SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 Stromelysin-1 Tryptase furin interstitial collagenase trypsin	A0A5K1VKB9 A0A8I3MCQ8 A0A8I3MF27 A0A8I3MGS0 A0A8I3MN73 A0A8I3MND9 A0A8I3MSY3 A0A8I3MWY2 A0A8I3MXC2 A0A8I3N1T9 A0A8I3N597 A0A8I3NK04 A0A8I3NM17 A0A8I3NXG0 A0A8I3P478 A0A8I3P5C4 A0A8I3PD99 A0A8I3PHE2 A0A8I3PMD6 A0A8I3PZ83 A0A8I3Q4H4 A0A8I3RPH1 A0A8I3S0N4 A0A8I3S3N5 P04813 P15944 P21842 Q6Y4Q5 Q8MJD1 Q9GL24 Q9TTY1	CMA1 COL18A1 CTRB CTRB1 CTSG CTSL CTSL1 ELA2 ELANE FURIN KLK1 KLK2 KLKB1 MMP1 MMP11 MMP13 MMP14 MMP15 MMP16 MMP17 MMP2 MMP24 MMP25 MMP3 MMP7 MMP8 MMP9 PLG PRSS2 SPOCK3 TIMP1 TIMP2	Canis familiaris (dog)
Sialic acid metabolism	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Beta-galactosidase Beta-galactoside alpha-2,6-sialyltransferase 2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase Carboxypeptidase Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Lactosylceramide alpha-2,3-sialyltransferase N-acetylneuraminate lyase N-acetylneuraminate synthase N-acylneuraminate cytidylyltransferase ST3 beta-galactoside alpha-2,3-sialyltransferase 3 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 Sialidase-1 Solute carrier family 17 member 5 Solute carrier family 35 member A1 Type 2 lactosamine alpha-2,3-sialyltransferase Uncharacterized protein alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase beta-galactoside alpha-(2,6)-sialyltransferase exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase	A0A8I3MKA0 A0A8I3MMF0 A0A8I3MQ19 A0A8I3MQZ3 A0A8I3MRB4 A0A8I3MRS4 A0A8I3MSL1 A0A8I3MWM9 A0A8I3MZA8 A0A8I3N2X1 A0A8I3N3C9 A0A8I3N9F9 A0A8I3NB27 A0A8I3NB67 A0A8I3NFK8 A0A8I3NHI8 A0A8I3NN43 A0A8I3NNC5 A0A8I3NR40 A0A8I3NVQ5 A0A8I3P0Y9 A0A8I3P9I7 A0A8I3PBB8 A0A8I3PGV9 A0A8I3Q6S3 A0A8I3RSF2 A0A8I3RV22 A0A8I3RWY3 A0A8I3RZ95 A0A8I3S0P4 A0A8I3S2B0 A0A8I3S5C7 Q9TRY9	CMAS CTSA GLB1 GNE NANP NANS NEU1 NEU2 NEU3 NEU4 NPL SLC17A5 SLC35A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6	Canis familiaris (dog)
Activation of the phototransduction cascade	Cyclic nucleotide gated channel subunit beta 1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(t) subunit alpha-1 Phosphodiesterase Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Rhodopsin Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta cGMP-gated cation channel alpha-1	A0A8I3MLZ0 A0A8I3MQ38 A0A8I3NB80 A0A8I3QE57 P33726 P54827 P62872 P63210 Q28263 Q28300	CNGA1 CNGB1 GNAT1 GNB1 GNGT1 PDBS PDE6A PDE6B PDE6G PDEA PDEB PDEG RHO	Canis familiaris (dog)
Trafficking and processing of endosomal TLR	Canopy FGF signaling regulator 3 Cathepsin B Cathepsin S Endoplasmin Legumain Procathepsin L Toll like receptor 3 Toll like receptor 7 Toll like receptor 8 Toll-like receptor 9 Toll-like receptor 9 Unc-93 homolog B1, TLR signaling regulator	A0A8I3N2H5 A0A8I3NCE8 A0A8I3P6K4 A0A8I3P8U9 A0A8I3P903 A0A8I3PZY7 A0A8I3Q7B4 A0A8I3S0M3 A0A8I3SBE6 P41148 Q5I2M8 Q9GL24	CNPY3 CTSB CTSL CTSL1 CTSS GRP94 HSP90B1 HSPC4 LGMN TLR3 TLR7 TLR8 TLR9 TRA1 UNC93B1	Canis familiaris (dog)
Collagen degradation	5-phosphohydroxy-L-lysine phospho-lyase 72 kDa type IV collagenase Cathepsin B Cathepsin D Collagen type XII alpha 1 chain Collagen type XIII alpha 1 chain Collagen type XIX alpha 1 chain Collagen type XV alpha 1 chain Collagen type XVIII alpha 1 chain Collagen type XXV alpha 1 chain Collagen type XXVI alpha 1 chain Collagenase 3 Matrix metallopeptidase 12 Matrix metallopeptidase 15 Matrix metallopeptidase 20 Matrix metallopeptidase 7 Matrix metallopeptidase 8 Matrix metalloproteinase-14 Matrix metalloproteinase-9 Stromelysin-1 Transmembrane serine protease 6 furin interstitial collagenase trypsin	A0A8I3MCQ8 A0A8I3MGS0 A0A8I3MJI6 A0A8I3MND9 A0A8I3MSY3 A0A8I3MWG8 A0A8I3MWY2 A0A8I3MX21 A0A8I3MXC2 A0A8I3N1T9 A0A8I3N1V6 A0A8I3N4V8 A0A8I3NL35 A0A8I3P478 A0A8I3PD99 A0A8I3PHE2 A0A8I3QKG6 A0A8I3RPH1 A0A8I3RPK2 A0A8I3RU13 A0A8I3RVF8 A0A8I3S0M3 Q4LAL9 Q6Y4Q5	COL12A1 COL13A1 COL15A1 COL18A1 COL19A1 COL25A1 COL26A1 CTSB CTSD FURIN MMP1 MMP12 MMP13 MMP14 MMP15 MMP2 MMP20 MMP3 MMP7 MMP8 MMP9 PHYKPL PRSS2 TMPRSS6	Canis familiaris (dog)
Signaling by PDGF	Collagen type IV alpha 1 chain Collagen type IV alpha 2 chain Collagen type IV alpha 3 chain Collagen type IV alpha 4 chain Collagen type IV alpha 5 chain Collagen type IX alpha 1 chain Collagen type IX alpha 2 Collagen type IX alpha 3 chain Plasminogen Platelet-derived growth factor C Platelet-derived growth factor D Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Secreted phosphoprotein 1 Thrombospondin 1 Thrombospondin 2 Thrombospondin 3 Thrombospondin 4 furin protein-tyrosine-phosphatase t-plasminogen activator	A0A8I3MF27 A0A8I3MGR1 A0A8I3MW94 A0A8I3N1T9 A0A8I3N488 A0A8I3NAN8 A0A8I3NB75 A0A8I3NC04 A0A8I3NEF4 A0A8I3NEX5 A0A8I3NL86 A0A8I3NM06 A0A8I3NMW4 A0A8I3NXU0 A0A8I3P1W2 A0A8I3P613 A0A8I3P8B9 A0A8I3PDX7 A0A8I3PJI8 A0A8I3PPU8 A0A8I3S0U4 E2DP67 Q6Q7I7	COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL9A1 COL9A2 COL9A3 FURIN PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PLAT PLG PTPN12 SPP1 THBS1 THBS2 THBS3 THBS4	Canis familiaris (dog)
Lectin pathway of complement activation	Collectin subfamily member 10 MBL associated serine protease 1 MBL associated serine protease 2 Uncharacterized protein	A0A8I3MRI0 A0A8I3NLF4 A0A8I3PG15 A0A8I3RST0	COLEC10 FCN2 MASP1 MASP2	Canis familiaris (dog)	G49108TO G57321FI
COX reactions	Prostaglandin G/H synthase 1	Q8HZR1	COX1 PTGS1	Canis familiaris (dog)
Metal ion SLC transporters	Copper transport protein Hephaestin Natural resistance-associated macrophage protein 1 Solute carrier family 11 member 2 Solute carrier family 30 member 10 Solute carrier family 40 protein member 1 Solute carrier family 41 member Solute carrier family 41 member ferroxidase	A0A8I3N3B2 A0A8I3N4Y2 A0A8I3PMF7 A0A8I3PWM1 A0A8I3PXW9 A0A8I3Q213 A0A8I3QCU8 A0A8I3RZ10 E2RFJ3	CP HEPH SLC11A1 SLC11A2 SLC30A10 SLC31A1 SLC40A1 SLC41A1 SLC41A2	Canis familiaris (dog)

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