GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **151 - 175** of **268** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism	GlyTouCan ID
Terminal pathway of complement	Clusterin Complement C5 Complement C7 Complement C8 alpha chain Complement C8 gamma chain Complement component C6 Complement component C8 beta chain Complement component C9	A0A8I3MKJ7 A0A8I3MQ72 A0A8I3MRL7 A0A8I3NT81 A0A8I3NVC1 A0A8I3P0T6 A0A8I3RSI3 P25473	C5 C6 C7 C8A C8B C8G C9 CLU	Canis familiaris (dog)
Interleukin-1 signaling	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin 1 E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase pellino homolog E3 ubiquitin-protein ligase pellino homolog IkappaB kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha Interleukin 1 receptor accessory protein Interleukin 1 receptor associated kinase 3 Interleukin 1 receptor type 1 Interleukin 1 receptor type 2 Interleukin-1 receptor antagonist protein Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-associated kinase-like 2 Interleukin-1 Mitogen-activated protein kinase kinase kinase 3 Mitogen-activated protein kinase kinase kinase 7 Multifunctional fusion protein Myeloid differentiation primary response protein MyD88 NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Pellino E3 ubiquitin protein ligase family member 3 Proteasome 20S subunit alpha 3 Proteasome 26S subunit, ATPase 1 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 10 Proteasome 26S subunit, non-ATPase 12 Proteasome 26S subunit, non-ATPase 14 Proteasome 26S subunit, non-ATPase 3 Proteasome 26S subunit, non-ATPase 7 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit beta type-8 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta RELA proto-oncogene, NF-kB subunit Ring-box 1 S-phase kinase-associated protein 1 Sequestosome 1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TNF receptor-associated factor 6 Toll interacting protein Ubiquitin B Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein Uncharacterized protein Uncharacterized protein mitogen-activated protein kinase kinase non-specific serine/threonine protein kinase	A0A8I3MKL4 A0A8I3MMN5 A0A8I3MNI0 A0A8I3MR89 A0A8I3MU16 A0A8I3MUE2 A0A8I3N0P1 A0A8I3N165 A0A8I3N2A1 A0A8I3N3S4 A0A8I3N4F2 A0A8I3N5F1 A0A8I3N5F6 A0A8I3N7L6 A0A8I3N952 A0A8I3N9G3 A0A8I3NBF5 A0A8I3NFB9 A0A8I3NH42 A0A8I3NHA9 A0A8I3NJ31 A0A8I3NMB6 A0A8I3NN65 A0A8I3NNJ9 A0A8I3NP41 A0A8I3NP66 A0A8I3NPR4 A0A8I3NPT2 A0A8I3NPX1 A0A8I3NUC6 A0A8I3NUK8 A0A8I3NVB6 A0A8I3NW81 A0A8I3NXK9 A0A8I3NXW3 A0A8I3NZN1 A0A8I3P046 A0A8I3P2V4 A0A8I3P3H3 A0A8I3P499 A0A8I3P4Z1 A0A8I3P6I7 A0A8I3P6M2 A0A8I3PB85 A0A8I3PBB2 A0A8I3PCE5 A0A8I3PCT4 A0A8I3PDR8 A0A8I3PF55 A0A8I3PF76 A0A8I3PGC5 A0A8I3PJH9 A0A8I3PJW0 A0A8I3PKH4 A0A8I3PLL0 A0A8I3PMA2 A0A8I3PN81 A0A8I3PV99 A0A8I3PZT2 A0A8I3Q059 A0A8I3Q209 A0A8I3QV78 A0A8I3QYD0 A0A8I3RRR7 A0A8I3RT39 A0A8I3RUU8 A0A8I3RXV3 A0A8I3RY59 A0A8I3RZF7 A0A8I3RZP6 A0A8I3S1Z6 A0A8I3S6C6 A0A8I3S6Q5 A0A8I3S792 E2R2I5 P63050 Q5W412 Q5W416 Q6F3J0 Q9BEH0	CHUK CUL1 IKBKB IKBKG IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IRAK1 IRAK2 IRAK3 IRAK4 LOC100686569 LOC100687259 LOC119881719 LOC610717 MAP2K6 MAP3K3 MAP3K7 MYD88 NFKB1 NFKBIA PELI1 PELI2 PELI3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RBX1 RELA RPS27A SKP1 SQSTM1 TAB1 TAB2 TAB3 TOLLIP TRAF6 UBA52 UBB UBC UBCEP2 UBE2N	Canis familiaris (dog)
Digestion of dietary carbohydrate	Alpha-amylase Lactase Maltase-glucoamylase Sucrase-isomaltase chitinase	A0A8I3MKS5 A0A8I3NDB4 A0A8I3P4Z5 A0A8I3QYQ3 J9PAL7	CHIA LCT LOC119879923 LOC119881526 MGAM SI	Canis familiaris (dog)	G58161NS G74621DY G93924TT G96370VA
Other interleukin signaling	Caspase-3 Colony stimulating factor 3 receptor Granulocyte colony-stimulating factor Interferon lambda receptor 1 Interleukin 29-like Interleukin 34 Macrophage colony-stimulating factor 1 Multifunctional fusion protein Pro-interleukin-16 Syndecan Syntaxin 4 Syntaxin-1A Syntaxin-binding protein 2 T-cell surface glycoprotein CD4 Taxilin alpha Tissue factor Tyrosine-protein kinase Tyrosine-protein kinase Vesicle-associated membrane protein 2 protein-tyrosine-phosphatase receptor protein-tyrosine kinase t-SNARE coiled-coil homology domain-containing protein	A0A8I3MKU0 A0A8I3MLF8 A0A8I3MP33 A0A8I3MU79 A0A8I3MWJ5 A0A8I3MXT5 A0A8I3NFS8 A0A8I3NN34 A0A8I3NNE2 A0A8I3NRN4 A0A8I3P3C6 A0A8I3P4F5 A0A8I3PNE3 A0A8I3PUZ4 A0A8I3Q7V8 A0A8I3QCQ2 A0A8I3RS40 A0A8I3S0X5 A0A8I3S6B0 A0A8I3S6J8 F1PS12 P33705	CASP3 CD4 CSF1 CSF1R CSF3 CSF3R IFNLR1 IL10RB IL16 IL29L IL34 JAK1 PTPRZ1 SDC1 SNAP25 STX1A STX3 STX4 STXBP2 TXLNA TYK2 VAMP2	Canis familiaris (dog)
Inactivation, recovery and regulation of the phototransduction cascade	Calmodulin-lysine N-methyltransferase Cyclic nucleotide gated channel subunit beta 1 EF-hand domain-containing protein G protein-coupled receptor kinase G protein-coupled receptor kinase G protein-coupled receptor kinase Glycylpeptide N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase Guanine nucleotide-binding protein G(t) subunit alpha-1 Guanine nucleotide-binding protein subunit beta-5 Guanylate cyclase activator 1C Guanylate cyclase Guanylate cyclase Guanylyl cyclase-activating protein 1 Methionine aminopeptidase 2 Methionine aminopeptidase Phosphodiesterase Recoverin Regulator of G protein signaling 9 binding protein Regulator of G-protein signaling 9 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Rhodopsin Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta S-arrestin Serine/threonine-protein phosphatase with EF-hands cGMP-gated cation channel alpha-1	A0A8I3MKZ0 A0A8I3MLZ0 A0A8I3MQ38 A0A8I3MR23 A0A8I3MSQ7 A0A8I3NB80 A0A8I3NDY5 A0A8I3NJ95 A0A8I3NUA6 A0A8I3P9Q1 A0A8I3PF51 A0A8I3PM46 A0A8I3PRB5 A0A8I3PV05 A0A8I3PV39 A0A8I3PWQ2 A0A8I3Q053 A0A8I3Q0S6 A0A8I3Q144 A0A8I3QE57 A0A8I3S5I9 A0A8I3S6V0 P33726 P54827 Q28263 Q28300 Q8MIH6	CALM2 CAMKMT CNGA1 CNGB1 GNAT1 GNB5 GRK1 GRK4 GRK7 GUCA1A GUCA1C GUCY2D GUCY2F METAP1 METAP2 NMT1 NMT2 PDBS PDE6A PDE6B PDE6G PDEA PDEB PDEG PPEF1 RCV1 RCVRN RGS9 RGS9BP RHO SAG	Canis familiaris (dog)
VxPx cargo-targeting to cilium	ADP-ribosylation factor ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Cyclic nucleotide gated channel subunit alpha 4 Cyclic nucleotide gated channel subunit beta 1 Cyclic nucleotide-gated olfactory channel Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 5 Exocyst complex component 7 Exocyst complex component 8 Exocyst complex component Sec8 Exocyst complex component Golgi brefeldin A resistant guanine nucleotide exchange factor 1 Polycystin-2 RAB11 family interacting protein 3 RAB3A interacting protein Ras-related protein Rab-11A Ras-related protein Rab-8A Rhodopsin	A0A8I3MLB7 A0A8I3MLZ0 A0A8I3N510 A0A8I3NMX3 A0A8I3NS37 A0A8I3NTX3 A0A8I3NZH4 A0A8I3NZH6 A0A8I3P3F1 A0A8I3PAA1 A0A8I3PH62 A0A8I3PMI1 A0A8I3PN68 A0A8I3PQE3 A0A8I3PZW4 A0A8I3QBX3 A0A8I3QE57 A0A8I3S0B6 P61007 P62490	ARF4 ASAP1 CNGA2 CNGA4 CNGB1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GBF1 MEL PKD2 RAB11 RAB11A RAB11FIP3 RAB3IP RAB8 RAB8A RHO	Canis familiaris (dog)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	78 kDa glucose-regulated protein ABC-type antigen peptide transporter Aminopeptidase Beta-2-microglobulin Calnexin Calreticulin GTP-binding protein SAR1b Immunoglobulin C1-set domain-containing protein MHC class I DLA-12 MHC class I DLA-64 MHC class I DLA-88 MHC class Ib Protein SEC13 homolog Protein disulfide-isomerase Protein transport protein SEC23 Protein transport protein Sec31A SEC24 homolog A, COPII coat complex component SEC24 homolog B, COPII coat complex component SEC24 homolog C, COPII coat complex component SEC24 homolog D, COPII coat complex component Tapasin	A0A8I3MLY2 A0A8I3N796 A0A8I3N9C4 A0A8I3NCJ5 A0A8I3NCT5 A0A8I3NDA5 A0A8I3NM03 A0A8I3NPS2 A0A8I3NRG2 A0A8I3NSU2 A0A8I3NZH7 A0A8I3P4F9 A0A8I3P4Y2 A0A8I3PXH7 A0A8I3Q7H2 A0A8I3RR85 A0A8I3RUA9 A0A8I3S449 A0A8I3S5M8 A0A8I3SCF9 Q5TJE4	B2M CALR CANX DLA-12 DLA-79 DLA-DOB DLA88 ERAP1 HSPA5 LOC119876190 LOC119876868 PDIA3 SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A TAPBP	Canis familiaris (dog)
Activation of the phototransduction cascade	Cyclic nucleotide gated channel subunit beta 1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(t) subunit alpha-1 Phosphodiesterase Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Rhodopsin Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta cGMP-gated cation channel alpha-1	A0A8I3MLZ0 A0A8I3MQ38 A0A8I3NB80 A0A8I3QE57 P33726 P54827 P62872 P63210 Q28263 Q28300	CNGA1 CNGB1 GNAT1 GNB1 GNGT1 PDBS PDE6A PDE6B PDE6G PDEA PDEB PDEG RHO	Canis familiaris (dog)
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Procathepsin L Serpin family B member 13	A0A8I3MMH2 Q9GL24	CTSL CTSL1 SERPINB13	Canis familiaris (dog)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	Autocrine motility factor receptor Derlin Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Proteasome 26S subunit, ATPase 1 Transitional endoplasmic reticulum ATPase UBX domain protein 1 UV excision repair protein RAD23 Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	A0A8I3MMN5 A0A8I3N153 A0A8I3N6X7 A0A8I3NFB9 A0A8I3NK06 A0A8I3NNJ9 A0A8I3NV83 A0A8I3PZS2 A0A8I3QYD0 A0A8I3RQN1 A0A8I3RW88 P63050	AMFR DERL1 ENGASE NGLY1 PSMC1 RAD23B RPS27A UBA52 UBB UBC UBCEP2 UBXN1 VCP	Canis familiaris (dog)	G03934XO G25577BM G28233ME G51034LA G86419OL
MET interacts with TNS proteins	Hepatocyte growth factor receptor Hepatocyte growth factor Integrin beta Tensin 3 Tensin 4	A0A8I3MMP8 A0A8I3N5C8 A0A8I3NGY1 A0A8I3NIW4 Q867B7	HGF ITGB1 MET TNS3 TNS4	Canis familiaris (dog)
Transport of bile salts and organic acids, metal ions and amine compounds	Choline transporter-like protein Choline transporter-like protein Choline transporter-like protein Choline transporter-like protein Choline transporter-like protein Multidrug and toxin extrusion protein Multidrug and toxin extrusion protein Solute carrier family 10 member 6 Solute carrier family 5 member 7 Urea transporter 1 Urea transporter 2	A0A8I3MMY0 A0A8I3MSY0 A0A8I3MT90 A0A8I3N5A5 A0A8I3NGN2 A0A8I3NPI6 A0A8I3NVU1 A0A8I3P335 A0A8I3PJ18 A0A8I3PWN4 A0A8I3RY71	SLC10A6 SLC14A1 SLC14A2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLC47A1 SLC47A2 SLC5A7	Canis familiaris (dog)
Serotonin receptors	5-hydroxytryptamine receptor 1A 5-hydroxytryptamine receptor 1B 5-hydroxytryptamine receptor 1D 5-hydroxytryptamine receptor 1E 5-hydroxytryptamine receptor 1F 5-hydroxytryptamine receptor 2A 5-hydroxytryptamine receptor 2B 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine receptor 4 5-hydroxytryptamine receptor 5A 5-hydroxytryptamine receptor 7 G-protein coupled receptors family 1 profile domain-containing protein	A0A8I3MN28 A0A8I3N6U6 A0A8I3NAA7 A0A8I3NLJ6 A0A8I3NMV4 A0A8I3PC67 A0A8I3RXP5 A0A8I3S1Q6 A0A8I3S5I1 A0A8I3S709 O46635 P79250	5-HTR2A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7	Canis familiaris (dog)
FGFR1b ligand binding and activation	Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GIPC PDZ domain containing family member 1 Multifunctional fusion protein Transforming growth factor beta receptor 3	A0A8I3MP09 A0A8I3NHF3 A0A8I3NNZ2 A0A8I3NSU7 A0A8I3NV07 A0A8I3NYK3 A0A8I3NZI6 A0A8I3PDK4	FGF1 FGF10 FGF22 FGF3 FGFR1 GIPC1 TGFBR3	Canis familiaris (dog)
HS-GAG degradation	Agrin Alpha-L-iduronidase Alpha-L-iduronidase Beta-galactosidase Beta-galactosidase Beta-glucuronidase Galactosidase beta 1 like Glypican 2 Glypican 4 Glypican 5 Glypican 6 Glypican-1 Glypican-3 Heparanase 2 (inactive) Heparanase Iduronate 2-sulfatase N-acetyl-alpha-glucosaminidase N-sulfoglucosamine sulfohydrolase Syndecan 4 Syndecan Syndecan	A0A8I3MPF1 A0A8I3MQQ0 A0A8I3MUC2 A0A8I3MXW0 A0A8I3N3H1 A0A8I3N3M6 A0A8I3NA03 A0A8I3NDU0 A0A8I3NJ98 A0A8I3NWG4 A0A8I3P4F5 A0A8I3P836 A0A8I3PLC3 A0A8I3Q139 A0A8I3Q4U0 A0A8I3Q662 A0A8I3QTG2 A0A8I3QZP4 Q01634 Q32KH3 Q9TRY9	AGRN GLB1 GLB1L GLB1L2 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB HPSE HPSE2 IDS IDUA NAGLU SDC1 SDC3 SDC4 SGSH ids	Canis familiaris (dog)	G01550VL G09546QO
A tetrasaccharide linker sequence is required for GAG synthesis	Agrin Beta-1,4-galactosyltransferase Biglycan Brevican core protein Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 Decorin Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Glypican 2 Glypican 4 Glypican 5 Glypican 6 Glypican-1 Glypican-3 Hexosyltransferase Neurocan Syndecan 4 Syndecan Syndecan Versican core protein Xylosyltransferase 1 Xylosyltransferase 2	A0A8I3MPF1 A0A8I3MRY4 A0A8I3MT87 A0A8I3MUC2 A0A8I3N3H1 A0A8I3N3M6 A0A8I3N5J5 A0A8I3N8Z0 A0A8I3N9S5 A0A8I3NUF9 A0A8I3NWG4 A0A8I3P4F5 A0A8I3P874 A0A8I3PDW3 A0A8I3PHY6 A0A8I3PLC3 A0A8I3PLU7 A0A8I3Q4U0 A0A8I3Q662 A0A8I3QZP4 A0A8I3RWN8 Q29393 Q5CAZ6 Q5QQ50	AGRN B3GALT6 B3GAT1 B3GAT2 B3GAT3 B4GALT7 BCAN BGN CSPG4 CSPG5 DCN DCN1C GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 NCAN SDC1 SDC3 SDC4 VCAN XYLT1 XYLT2	Canis familiaris (dog)
Pentose phosphate pathway	6-phosphogluconate dehydrogenase, decarboxylating 6-phosphogluconolactonase Glucose-6-phosphate 1-dehydrogenase Phosphoglucomutase 2 Ribokinase Ribulose-phosphate 3-epimerase Sedoheptulokinase Transaldolase Transketolase deoxyribose-phosphate aldolase ribose-5-phosphate isomerase	A0A8I3MQ54 A0A8I3MSC7 A0A8I3NN17 A0A8I3P237 A0A8I3P626 A0A8I3Q4Y1 A0A8I3Q7C5 A0A8I3RVI9 A0A8I3RZI7 A0A8I3S1Y7 A0A8I3SAK1	DERA G6PD PGD PGLS PGM2 RBKS RPE RPIA SHPK TALDO1 TKT	Canis familiaris (dog)	G31080DL
Phase I - Functionalization of compounds	Aldehyde dehydrogenase, dimeric NADP-preferring Amine oxidase Amine oxidase Amine oxidase Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor repressor Aryl hydrocarbon receptor Arylacetamide deacetylase Biphenyl hydrolase like Carbonyl reductase (NADPH) Carboxylesterase 5A Carboxylic ester hydrolase Carboxymethylenebutenolidase homolog Cytochrome P450 2B11 Cytochrome P450 3A12 Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Cytochrome b5 heme-binding domain-containing protein Epoxide hydrolase N-ribosyldihydronicotinamide NADH-cytochrome b5 reductase 3 Uncharacterized protein	A0A8I3MQC6 A0A8I3MQJ9 A0A8I3MTP2 A0A8I3MW51 A0A8I3MYY3 A0A8I3N2D1 A0A8I3N2L9 A0A8I3NCL9 A0A8I3NJM7 A0A8I3NXH1 A0A8I3P2J3 A0A8I3P5C0 A0A8I3P8N1 A0A8I3PRW1 A0A8I3PU35 A0A8I3PV37 A0A8I3PXU4 A0A8I3QDM5 A0A8I3RP60 A0A8I3RSX6 A0A8I3RXZ4 A3RF36 P24463 Q0X0E5	AADAC AHR AHRR ALDH3 ALDH3A1 AOC2 AOC3 ARNT ARNT2 BPHL C5BR CBR3 CES2 CES5A CMBL CYB5B CYB5R3 CYP2B6 CYP3A12 DIA1 EPHX1 LOC119868939 LOC119875773 LOC119876349 MTARC1 NQO2	Canis familiaris (dog)
Atorvastatin ADME	ABC-type glutathione-S-conjugate transporter ATP binding cassette subfamily B member 1 Cytochrome P450 3A12 Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Paraoxonase 3 Paraoxonase Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member	A0A8I3MQC6 A0A8I3N2I4 A0A8I3NMC0 A0A8I3NUI6 A0A8I3PAM3 A0A8I3PDF6 A0A8I3PU35 A0A8I3PV37 A0A8I3SCV5 P24463	ABCB1 ABCC2 CYP3A12 LOC119868939 LOC119875773 LOC119876349 PON1 PON3 SLCO1B2 SLCO1B3 SLCO2B1	Canis familiaris (dog)
TNF signaling	ADAM metallopeptidase domain 17 Receptor interacting serine/threonine kinase 1 TNF receptor-associated factor TNFR-Cys domain-containing protein Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor	A0A8I3MQC7 A0A8I3NEJ2 A0A8I3PPY4 A0A8I3Q3L1 A0A8I3S2L7 P51742	ADAM17 RIPK1 TNF TNFA TNFRSF1A TNFSF2 TRADD TRAF2	Canis familiaris (dog)
Prostanoid ligand receptors	Prostaglandin D2 receptor 2 Prostaglandin D2 receptor Prostaglandin E2 receptor EP1 subtype Prostaglandin E2 receptor EP2 subtype Prostaglandin E2 receptor EP3 subtype Prostaglandin E2 receptor EP4 subtype Prostaglandin F2-alpha receptor Thromboxane A2 receptor Uncharacterized protein	A0A8I3MQM7 A0A8I3MUB8 A0A8I3NCM2 A0A8I3NNN1 A0A8I3P5Y8 Q45FN0 Q9BGL8 Q9TU16 Q9XT82	PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR TBXA2R	Canis familiaris (dog)
Glycosphingolipid catabolism	Acid ceramidase Alpha-galactosidase Arylsulfatase A Arylsulfatase B Arylsulfatase F Arylsulfatase G Arylsulfatase K Arylsulfatase L Arylsulfatase family member H Arylsulfatase family member I Arylsulfatase family member J Beta-galactosidase Beta-galactosidase Beta-hexosaminidase Beta-hexosaminidase Carboxypeptidase Ectonucleotide pyrophosphatase/phosphodiesterase 7 Galactocerebrosidase Galactosidase beta 1 like Ganglioside GM2 activator Glucosylceramidase beta 3 (gene/pseudogene) Glucosylceramidase Mannose-6-phosphate receptor, cation dependent Neutral ceramidase Non-lysosomal glucosylceramidase Prosaposin Sialidase-1 Sphingomyelin phosphodiesterase Steroid sulfatase Sulfatase modifying factor 1 Sulfatase modifying factor 2 Uncharacterized protein exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase sphingomyelin phosphodiesterase sphingomyelin phosphodiesterase	A0A8I3MQM8 A0A8I3MQQ0 A0A8I3MQZ3 A0A8I3MY15 A0A8I3MZE8 A0A8I3N2H8 A0A8I3NC41 A0A8I3NF27 A0A8I3NH12 A0A8I3NJQ3 A0A8I3NK36 A0A8I3NK85 A0A8I3NN43 A0A8I3NQ68 A0A8I3NUS9 A0A8I3NZ71 A0A8I3PAY1 A0A8I3PBB8 A0A8I3PGV9 A0A8I3PHI8 A0A8I3PN86 A0A8I3PNW9 A0A8I3PP93 A0A8I3PPB0 A0A8I3PT92 A0A8I3Q0D0 A0A8I3Q139 A0A8I3Q2D2 A0A8I3Q545 A0A8I3Q695 A0A8I3RTW7 A0A8I3RW96 A0A8I3RZ95 A0A8I3S3Z3 Q32KH0 Q32KI4 Q9TRY9	ARSA ARSB ARSF ARSG ARSH ARSI ARSJ ARSK ARSL ASAH1 ASAH2 CTSA ENPP7 GALC GBA1 GBA2 GBA3 GLA GLB1 GLB1L GLB1L2 GM2A HEXA HEXB M6PR NEU1 NEU2 NEU3 NEU4 PSAP SMPD1 SMPD2 SMPD3 SMPD4 STS SUMF1 SUMF2 arsb	Canis familiaris (dog)	G09546QO G27025MB G58161NS
Keratan sulfate degradation	Aggrecan core protein Beta-galactosidase Beta-galactosidase Beta-hexosaminidase Beta-hexosaminidase Fibromodulin Galactosidase beta 1 like Keratocan Lumican Mimecan N-acetylglucosamine-6-sulfatase Osteomodulin Proline and arginine rich end leucine rich repeat protein	A0A8I3MQQ0 A0A8I3MS95 A0A8I3MY15 A0A8I3NEJ3 A0A8I3P4B0 A0A8I3P684 A0A8I3PHJ7 A0A8I3PNW9 A0A8I3PS70 A0A8I3Q139 A0A8I3S110 A0A8I3S4Y4 Q9TRY9	ACAN FMOD GLB1 GLB1L GLB1L2 GNS HEXA HEXB KERA LUM OGN OMD PRELP	Canis familiaris (dog)	G09546QO G20239CJ G27025MB G50451AA G80016QC G82768YB G85384LV
Integrin signaling	3-phosphoinositide-dependent protein kinase 1 Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Fibronectin Focal adhesion kinase 1 Integrin beta Integrin subunit alpha 2b RAS guanyl releasing protein 2 RAS guanyl-releasing protein 1 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 SHC-transforming protein 1 Talin 1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type small monomeric GTPase small monomeric GTPase von Willebrand factor von Willebrand factor	A0A8I3MQX7 A0A8I3N6K0 A0A8I3N737 A0A8I3NMY1 A0A8I3NUL4 A0A8I3NUU1 A0A8I3P3G0 A0A8I3P4Z0 A0A8I3PED8 A0A8I3PMU9 A0A8I3PW63 A0A8I3PWD7 A0A8I3PXV2 A0A8I3PZ28 A0A8I3Q868 A0A8I3RUF3 A0A8I3RVR5 A0A8I3SBF9 A0A8I3SCK0 Q28295	APBB1IP CSK F8VWF FN1 ITGA2B ITGB3 PDPK1 PTK2 PTPN1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SHC1 SRC SYK TLN1 VWF	Canis familiaris (dog)
Phase 4 - resting membrane potential	Inward rectifier potassium channel 2 Inward rectifier potassium channel Potassium channel domain-containing protein Potassium channel subfamily K member 9 Potassium channel subfamily K member Potassium inwardly rectifying channel subfamily J member 14 Potassium two pore domain channel subfamily K member 10 Potassium two pore domain channel subfamily K member 12 Potassium two pore domain channel subfamily K member 13 Potassium two pore domain channel subfamily K member 15 Potassium two pore domain channel subfamily K member 16 Potassium two pore domain channel subfamily K member 17 Potassium two pore domain channel subfamily K member 18 Potassium two pore domain channel subfamily K member 4 Potassium two pore domain channel subfamily K member 5 Potassium two pore domain channel subfamily K member 6 Potassium two pore domain channel subfamily K member 7	A0A8I3MR75 A0A8I3MTD8 A0A8I3MV05 A0A8I3N317 A0A8I3NAZ8 A0A8I3NNF9 A0A8I3NSP8 A0A8I3NUT1 A0A8I3NUY1 A0A8I3P863 A0A8I3Q3Z0 A0A8I3Q644 A0A8I3RRG3 A0A8I3S0J2 A0A8I3S6X0 F6KIF6 Q9MYY9	IRK1 KCNJ12 KCNJ14 KCNJ2 KCNK1 KCNK10 KCNK12 KCNK13 KCNK15 KCNK16 KCNK17 KCNK18 KCNK3 KCNK4 KCNK5 KCNK6 KCNK7 KCNK9	Canis familiaris (dog)

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