GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **76 - 100** of **252** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	alpha-1,2-Mannosidase	B0V2X9	fj20e02 man1a2 si:dkey-174k18.8 wu:fj20e02	Danio rerio (zebrafish)	G70323CJ
Platelet homeostasis	P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor	B0R182 Q7SZL9 Q7SZM0 Q7SZM1 Q7SZM2 Q9I8N8	P2X.514 P2X3 fb99b08 p2rx1 p2rx2 p2rx3 p2rx3a p2rx5 p2rx7 p2rx8 p2x3 p2x5 p2xr1 p2xr2 p2xr514 p2xr7 wu:fb99b08 zP2X3 zfP2X3	Danio rerio (zebrafish)
Platelet degranulation	Actin, cytoplasmic 2 Actinin, alpha 2 Alpha-1-antiproteinase 2-like Alpha-2-HS-glycoprotein precursor Alpha-2-antiplasmin precursor Amyloid-beta A4 protein Annexin Apolipoprotein A-Ia C-fos induced growth factor Cathepsin F Chemokine (C-X-C motif) ligand 8b, duplicate 1 Chemokine CXCL-C13c Chitinase domain-containing protein 1 Clusterin Coagulation factor V Coagulation factor XIII A chain Complement factor D (adipsin) Cystic fibrosis transmembrane conductance regulator Endonuclease domain-containing 1 protein-like Family with sequence similarity 49 member Bb Fetuin-B precursor Fructose-bisphosphate aldolase Galectin-3-binding protein A Glycoprotein IIb Growth arrest-specific 6 Hsp90 co-chaperone Cdc37-like 1 INO80 complex subunit E Insulin-like growth factor 1 Insulin-like growth factor 2 Integrin beta Inter-alpha-trypsin inhibitor heavy chain H3 LHFPL tetraspan subfamily member 2a protein Left-right determination factor Left-right determination factor MICOS complex subunit Mage Mesencephalic astrocyte-derived neurotrophic factor precursor Metalloproteinase inhibitor 2 Metalloproteinase inhibitor 2 Metavinculin NADH-cytochrome b5 reductase Novel protein similar to vertebrate endonuclease domain containing 1 (ENDOD1) Obg-like ATPase 1 Plasminogen activator inhibitor 1 Platelet glycoprotein 4 Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Pleckstrin Protein FAM3C Retinoic acid receptor responder protein 2 SPARC Saccharopine dehydrogenase-like oxidoreductase Secretogranin-3 Selenoprotein Pa Si Superoxide dismutase [Cu-Zn] Synaptotagmin-like protein 4 Syntaxin-binding protein 2 Testis-expressed 264, ER-phagy receptor a Tetraspanin Thymosin beta Torsin-4A Transforming growth factor beta Transforming growth factor beta Transforming growth factor beta Transgelin Uncharacterized protein LOC100136837 Uncharacterized protein LOC564384 precursor Uncharacterized protein LOC793035 precursor Vascular endothelial growth factor A-A Vascular endothelial growth factor C Vesicle transport through interaction with t-SNAREs 1B Vitamin K-dependent protein S p-selectin protein disulfide-isomerase von Willebrand factor	A0A0R4IVU6 A0A2R8Q0D8 A1A5Y8 A2RRV8 A3KQQ9 A5D6T5 A5PM73 A7YY97 A8WFS5 A8WFS6 A8WGQ0 A9JRH2 A9ZPF0 B3DI32 B3DIP4 B7ZVT7 E5DV48 E7F9Z1 F1RE14 F8W5D3 N0GW19 O42363 O73682 O73872 Q08BB9 Q08BC3 Q08CA3 Q08CA7 Q08CD2 Q0IIP9 Q208T6 Q24JV9 Q2YDR5 Q3LTM5 Q45QT2 Q503P4 Q568B8 Q58EI3 Q66I23 Q6DBS8 Q6DHB9 Q6DHC7 Q6EIY7 Q6IQH0 Q6NUX6 Q6NUX9 Q6NUZ1 Q6NYL6 Q6P018 Q6P0C6 Q6P110 Q6P2T9 Q6P7E2 Q6PBL3 Q6TGT5 Q7SY45 Q7SYK0 Q7SZM6 Q7SZV4 Q7T0K5 Q7T3H4 Q7T3I6 Q7ZU42 Q7ZVF8 Q7ZVF9 Q7ZYY4 Q7ZZU7 Q800S8 Q803A1 Q803Q7 Q8JIE4 Q8QFL6 Q90VV9 Q98SV1 Q9PW55 Q9W6I7	ANX V CYB5R1 IGF-1 IGF-1L IGF-1a IGF-I LOC792613 MRP PAI PAI-1 PAI1 PLANH1 TAGLN Tbeta11 VWF abcc4 actbb actn2 actn2b ahsg ahsg1 ai39657 aldoa aldoaa antivin anx anx5 anxa5 anxa5b apoa apoa1 apoa1a apool app appa atv atv2 bactin2 cb1019 cb223 cb420 cb720 cb73 cb79 cb989 cd163 cd36 cd63 cdc37l1 cfd cfdl chid1 clu ctsf cuzn cxcl-c13d cxcl8b.1 cxcl8b.3 cyb5r1 dZ52I16.4 dia1 etID32613.12 f13a1 f13a1b f5 fa92e03 fa96h09 fam3c fam49bb fb08c07 fb11g09 fb52d02 fb61f12 fb63c02 fc21c08 fc21h08 fe38b03 fi27b02 figf fj34a12 fj40h03 fo83d04 gas6 hm:zeh0062 hm:zehn2160 igf1 igf2 igf2a igf2b ik:tdsubc_2b12 il8l1 im:6902790 im:6909481 im:7044540 im:7144020 ino80e itga2b itgb3.1 itgb3b itih3a itih3a.1 lft1 lft2 lgals3bp lgals3bpa lhfpl2a mage manf ndnl2 ola1 pdgfab pdgfbb plek pros1 sb:cb420 sb:cb79 sccpdha sccpdha.1 scg3 selp sepp1a serpine1 serpinf2b si:busm1-52i16.4 si:bz20i5.3 si:ch1073-474e24.1 si:ch211-133n4.4 si:ch211-138a11.1 si:ch211-165i18.2 si:ch211-186e20.7 si:ch211-229i10.3 si:ch211-260g14.4 si:ch211-284e20.8 si:ch73-54f23.2 si:dkey-243k1.3 si:dkey-27b3.6 si:dkey-46g23.4 si:dkeyp-105g12.2 si:dz202l16.5 si:dz52i16.4 sm22[a] sod1 sparc stxbp2 sytl4 tagln2 tagln3 tex264a tgfb1 tgfb1a tgfb2 tgfb3 timp2 timp2a timp2b timp2l tmsb4x tmx3b tor4a vcl vcla vegf vegf-d vegfa vegfaa vegfc vegfd vti1b vwf wu:fa28b10 wu:fa92e03 wu:fa96h09 wu:fa98f06 wu:fb08c07 wu:fb10b11 wu:fb11g09 wu:fb13a07 wu:fb13e02 wu:fb15h03 wu:fb16b08 wu:fb52d02 wu:fb61f12 wu:fb63c02 wu:fb63g02 wu:fc21c08 wu:fc21h08 wu:fc32c12 wu:fc34h12 wu:fc78g09 wu:fd21h06 wu:fd44c03 wu:fe38b03 wu:fi27b02 wu:fj08a12 wu:fj10f10 wu:fj34a12 wu:fj34d10 wu:fj40h03 wu:fk65e12 wu:fo83d04 xx:ai39657 xx:tdsubc_2b12 zgc:101850 zgc:103687 zgc:109940 zgc:123223 zgc:136726 zgc:153093 zgc:153249 zgc:153327 zgc:153334 zgc:153988 zgc:154001 zgc:158410 zgc:171446 zgc:172339 zgc:195198 zgc:56042 zgc:63525 zgc:63860 zgc:65825 zgc:65967 zgc:66013 zgc:73352 zgc:77709 zgc:85740 zgc:85799 zgc:85807 zgc:92058 zgc:92376 zgc:92513 zgc:92525	Danio rerio (zebrafish)
Platelet Adhesion to exposed collagen	Glycoprotein Ib platelet subunit beta LOC100004428 protein Nyctalopin Tsukushi von Willebrand factor	A4QNV9 B8JLP1 E7F9Z1 Q00P20 Q58A48	LOC100004428 VWF gp1bb lrcc54 nyx si:ch1073-474e24.1 si:dkey-285c2.8 tsk tsku vasn vasnb vwf	Danio rerio (zebrafish)
Phospholipase C-mediated cascade; FGFR4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma FGF18a Fgf23 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 8 Fibroblast growth factor receptor 4 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Putative fibroblast growth factor 1	B3DGE3 O57341 Q2HXK8 Q38PL0 Q5MK87 Q5TKR8 Q5TLE1 Q6PBT8 Q6SJP8 Q804J6 Q90413 Q9DFC9	dob fc89b01 fgf-1 fgf-8 fgf1 fgf16 fgf17 fgf17b fgf18 fgf18a fgf2 fgf20a fgf23 fgf4 fgf6b fgf8 fgf8a fgfr4 fj46f04 id:ibd5158 plcg1 wu:fb05c08 wu:fc89b01 wu:fj46f04 wu:fj57a05 zgc:194535	Danio rerio (zebrafish)
Phospholipase C-mediated cascade; FGFR3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma FGF18a Fgf23 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 8 Fibroblast growth factor receptor 3 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Putative fibroblast growth factor 1	B3DGE3 O57341 Q2HXK8 Q38PL0 Q5MK87 Q5TKR8 Q5TLE2 Q6PBT8 Q6SJP8 Q804J6 Q9DFC9 Q9I8X3	dob fc89b01 fgf-1 fgf-8 fgf1 fgf16 fgf17 fgf17b fgf18 fgf18a fgf2 fgf20a fgf23 fgf4 fgf5 fgf8 fgf8a fgfr3 fj46f04 id:ibd5158 plcg1 wu:fb05c08 wu:fc89b01 wu:fj46f04 wu:fj57a05	Danio rerio (zebrafish)
Phospholipase C-mediated cascade; FGFR2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma FGF18a Fgf23 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 3 Fibroblast growth factor 8 Fibroblast growth factor receptor 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Putative fibroblast growth factor 1	B3DGE3 B3DHR9 O57341 P48802 Q1XG76 Q2HXK8 Q38PL0 Q5MK87 Q5TKR8 Q5TLE1 Q5TLE2 Q6PBT8 Q6SJP8 Q804J6 Q8AY90 Q8JG38 Q9DFC9	dob fc89b01 fgf-1 fgf-10 fgf-3 fgf-8 fgf1 fgf10 fgf10a fgf16 fgf17 fgf17b fgf18 fgf18a fgf2 fgf20a fgf22 fgf23 fgf3 fgf4 fgf5 fgf6b fgf7 fgf8 fgf8a fgfr2 fj46f04 id:ibd5158 plcg1 si:dkey-21e2.2 si:dkeyp-74c5.3 wu:fb05c08 wu:fc89b01 wu:fd11d03 wu:fj46f04 wu:fj57a05 zgc:109774 zgc:194535	Danio rerio (zebrafish)
Phospholipase C-mediated cascade: FGFR1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fgf23 Fibroblast growth factor 17 Fibroblast growth factor 3 Fibroblast growth factor 8 Fibroblast growth factor receptor 1-A Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Klotho Putative fibroblast growth factor 1	B3DGE3 F1RC43 O57341 P48802 Q1XG76 Q38PL0 Q5MK87 Q5TLE1 Q5TLE2 Q6PBT8 Q6SJP8 Q804J6 Q8AY90 Q90Z00 Q9DFC9	dob fc89b01 fgf-1 fgf-10 fgf-3 fgf-8 fgf1 fgf10 fgf10a fgf17 fgf17b fgf2 fgf20a fgf22 fgf23 fgf3 fgf4 fgf5 fgf6b fgf8 fgf8a fgfr1 fgfr1a fj46f04 id:ibd5158 kl plcg1 si:dkey-21e2.2 si:dkeyp-74c5.3 wu:fb05c08 wu:fc89b01 wu:fd11d03 wu:fj46f04 wu:fj57a05 zgc:109774 zgc:194535	Danio rerio (zebrafish)
Phase 4 - resting membrane potential	ATP-sensitive inward rectifier potassium channel 12-like ATP-sensitive inward rectifier potassium channel 14 Inward rectifier potassium channel 2 Potassium channel protein TREK2A Potassium channel subfamily K member 13 Potassium channel subfamily K member 18 Potassium channel subfamily K member 5 Potassium channel subfamily K member Potassium channel, subfamily K, member 2b	A3QJX1 A5PLK0 A8KB76 D7NVC0 E7F807 E7FGH1 F1R7M8 Q32LX0 Q32PR9	KCNK18 TREK-2A im:7150627 kcnj12b kcnj14 kcnj2 kcnj2a kcnk1 kcnk10a kcnk13a kcnk18 kcnk1a kcnk2b kcnk5a si:ch211-120k19.4 si:dkey-121j17.4 si:dkey-63b1.2 trek-1 zgc:123268 zgc:123271	Danio rerio (zebrafish)
Peptide ligand-binding receptors	Adrenocorticotropic hormone receptor Angiotensinogen Apelin receptor 2 Apelin receptor A Apelin receptor B Apelin Cortistatin Endothelin receptor type B Endothelin-1 receptor Endothelin-1 Endothelin-3 Endothelin-3a Endothelin-converting enzyme 1 G protein-coupled receptor 54-2 G-protein coupled estrogen receptor 1 Galanin peptides Galanin receptor 2a KiSS-1 metastasis suppressor Melanocortin 3 receptor Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor Neuropeptide Y /peptide YY receptor Yb Neuropeptide Y receptor Y4 Neuropeptide Y receptor Y8a Neuropeptide Y receptor type 1 Neurotensin receptor 1 (high affinity) Neurotensin/neuromedin N Opioid receptor, delta 1b Peptide YY-A Pro-neuropeptide Y Pro-opiomelanocortin precursor Proenkephalin Prokineticin 1 Prokineticin receptor 1b Prokineticin receptor Prokineticin Somatostatin precursor Somatostatin receptor 1b Somatostatin receptor type 5 Type-1 angiotensin II receptor Type-2 angiotensin II receptor	A0A0A7H8E2 A0A0K0WSQ7 A0A1D5NSQ4 A0JMP1 A0T2N3 A7MC07 A7UD89 A8C5J1 A8CAH4 B0V1P1 B3DH72 B3DIJ2 B3DLG5 B3G515 D3GDN2 D3TZW2 D3TZW3 E7EZ19 E7EZ53 E7FEQ8 E9QFS0 F1QJG4 F1QQG9 F1R332 O57463 O73734 Q0P3Y2 Q4TTN8 Q5CZS2 Q6NV10 Q7SZP9 Q7T3L0 Q7ZT18 Q7ZTA2 Q7ZTA3 Q8JGW1 Q8JH29 Q8JHX5 Q9DGM2 Q9I8G3 Q9I8P2 Q9I8P3	ACTH DOR2 EDN3 EDN3a Ednra2 MSH NPYRYC Npy1r PPSS1 PPSS3 SI:bZ36D5.1 SI:bZ36D5.4 SS1 SS2 agt agtr1b agtr2 agtrl1 agtrl1a agtrl1b apln aplnr2 aplnr3 aplnra aplnrb cort ece1 edn1 edn3 edn3b ednr-a ednra ednraa ednrb1 ednrb1a ednrba et-1 fb12g05 fb14d01 fd11b07 fd57e04 gal galn galr2a gper1 grn im:7160079 kiss1 kiss1rb mc1r mc2r mc3r mc4r mc5br mc5ra mc5rb npy npy1r npy4r npy8ar npy8br npyrya npyryb npyryc nts ntsr1 oprd1b or4 penk penkb pomc pomca ppg prok1 prok2 prokr1a prokr1b prokr1l pyy pyya sb:eu249 si:bz36d5.2 si:ch211-157p22.8 si:ch211-202p1.5 si:ch211-44l19.2 si:dkey-211h10.1 si:dkey-253i9.3 sst1 sst1.1 sst3 sst7 sstr1b sstr5 wu:fb12g05 wu:fb14d01 wu:fb62f06 wu:fb75g12 wu:fd11b07 wu:fd57e04 wu:fj87b02 zMC5b zgc:111892 zgc:113016 zgc:153708 zgc:154079 zgc:194217 zgc:194235 zgc:194624 zgc:194648 zgc:194694 zgc:194705 zgc:195074 zgc:195090 zgc:92779 zya zyb	Danio rerio (zebrafish)
Pentose phosphate pathway	6-phosphogluconate dehydrogenase, decarboxylating Phosphoglucomutase-2 Ribokinase Ribulose-phosphate 3-epimerase Transaldolase deoxyribose-phosphate aldolase ribose-5-phosphate isomerase	F1Q883 Q5U3H4 Q5XJS7 Q6IQD5 Q6NYE3 Q6P6Y0 Q6PBW9	RBKS Tal dera fi03d03 ik:tdsubc_2c8 pgd pgm2 rbks rpe rpia taldo1 wu:fa07h08 wu:fb93d11 wu:fc20b11 wu:fc32g02 wu:fi03d03 xx:tdsubc_2c8 zgc:101610 zgc:103524 zgc:111848 zgc:55585 zgc:66054 zgc:77113 zgc:86813	Danio rerio (zebrafish)	G31080DL
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Adapter molecule crk Dedicator of cytokinesis 1 GTPase HRas GTPase NRas Paxillin RAS p21 protein activator (GTPase-activating protein) 1b Ras-related C3 botulinum toxin substrate 1 Rho GTPase-activating protein 35 Rho-related GTP-binding protein RhoA-C Tyrosine-protein kinase	A8E1V6 E7F372 E7F8G5 P79737 Q08BY6 Q503B6 Q6DEM2 Q6R3L1 Q7T2E8 Q7ZSZ9	LOC100004299 arhgap35a crk dock1 fb34h10 fc05a01 fi19g05 hrasb hrasl nras ptk6b pxn pxna rac1 rac1a rasa1b rhoac wu:fb34h10 wu:fc05a01 wu:fc54a04 wu:fd16e02 wu:fi19g05 wu:fw71f12 zgc:100936 zgc:110734 zgc:153964 zgc:55823 zgc:55917 zgc:86934	Danio rerio (zebrafish)
PRC2 methylates histones and DNA	DNA (cytosine-5-)-methyltransferase Histone H2A.V Histone H2A Histone H2A Histone H2A Histone H2B 1/2 Histone H2B 3 Histone H2B Histone H2B Histone H2B Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Metal-response element-binding transcription factor 2 Polycomb protein eed Polycomb protein suz12-B Protein Jumonji Uncharacterized protein LOC100126107 Zinc finger protein AEBP2	A3KPR4 A7E2M8 A7MCA8 B0R1D5 B3DJF8 Q08BS4 Q0Z946 Q1JQ07 Q1LVC2 Q4QRF4 Q566T0 Q588C6 Q5BJA5 Q5XJK2 Q6P3H7 Q6PC60 Q6PI20 Q71PD7 Q7SXV2 Q7ZTT0 Q7ZTY4 R4GE15	LOC100150038 LOC100329358 LOC100331412 LOC100332229 LOC103908680 LOC108181627 LOC562770 LOC570661 LOC794549 aebp2 cb633 dnmt3b dnmt3bb.1 dnmt4 eed ezh2 h2af1al h2afvb h2afvl h2afx1 h2afza h2av h2ax1 h2az2a h2az2b h3-5 h3f3a h3f3b.1 h3f3c h3f3d hist2h2l im:6896397 jarid2b jmj mtf2 rbb4 rbb4l rbbp4 rbbp7 si:ch211-113a14.17 si:ch211-113a14.29 si:ch211-113a14.6 si:ch73-36p18.4 si:dkey-108k21.12 si:dkey-108k21.18 si:dkey-108k21.28 si:dkey-23a13.7 suz12 suz12b wu:cegs2813 zgc:112234 zgc:113984 zgc:136399 zgc:152758 zgc:173585 zgc:173587 zgc:194998 zgc:56685	Danio rerio (zebrafish)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Betacellulin, epidermal growth factor family member Epigen Esr2a protein Estrogen receptor Fgf23 Fibroblast growth factor 17 Fibroblast growth factor 3 Fibroblast growth factor 8 Fibroblast growth factor receptor 1-A Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2a Kit ligand Klotho Mast/stem cell growth factor receptor kita Mitogen-activated protein kinase Mitogen-activated protein kinase Neuregulin 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma Phosphoinositide 3-kinase adapter protein 1 Phosphoinositide-3-kinase, regulatory subunit 3A (gamma) Platelet-derived growth factor receptor alpha Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Proheparin-binding EGF-like growth factor Protein phosphatase 2 (Formerly 2A), regulatory subunit A, beta isoform Proto-oncogene tyrosine-protein kinase Src Putative fibroblast growth factor 1 Rac family small GTPase 2 Radiation-inducible immediate-early gene IEX-1 Ras homolog family member Gb Ras-related C3 botulinum toxin substrate 1 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Serine/threonine protein phosphatase 2A regulatory subunit Serine/threonine-protein phosphatase Serine/threonine-protein phosphatase Striatin non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A0R4INZ6 A0A0R4IUJ2 A0A0R4IWG0 A0A2R8Q0D8 A0PJR9 A1L1U1 A4QP33 A9JRW9 B0S6V7 B3DGE3 B3DHG9 B3DJ34 B8LFF6 E7EXT6 E7F251 E7FGA4 F1QAD7 F1QIR0 F1RC43 O57341 P48802 P57717 Q08CD2 Q1JPZ3 Q1XG76 Q38PL0 Q503I3 Q567Y8 Q56JH6 Q5EBY4 Q5G254 Q5MK87 Q5RKN6 Q5TLE1 Q5TLE2 Q642H5 Q6IQE1 Q6IQN5 Q6PBT8 Q6PC73 Q6SJP8 Q7SYE7 Q7SZF7 Q7ZSZ9 Q7ZU32 Q7ZVK8 Q7ZW72 Q803F2 Q803G3 Q8AY90 Q8JFR5 Q90Z00 Q9DE49 Q9DFC9	ARHG EGFR12 EGFR15 ERK1 ER[b]2 ER[b]a LOC560360 NRG2b akt3b btc dob egfr egfra epgn erbb2 erbb3 erbb3b erbb4 erbb4a erbeta2 esr esr1 esr2a fb17h07 fb18e12 fc05c02 fc89b01 fgf-1 fgf-10 fgf-3 fgf-8 fgf1 fgf10 fgf10a fgf17 fgf17b fgf2 fgf20a fgf22 fgf23 fgf3 fgf4 fgf5 fgf6b fgf8 fgf8a fgfr1 fgfr1a fi06b09 fk24a01 grb2 grb2a grb2b hbegfa id:ibd5158 ik:tdsubc_2h3 im:7139868 kit kita kitla kitlga kl mapk1 mapk3 nr3a1 nrg2b pdgfab pdgfbb pdgfra pik3ap1 pik3ca pik3cb pik3cd pik3r1 pik3r2 pik3r3a pip4k2a pip4k2aa pip4k2c pip5k1a pip5k1aa pip5k2 pip5k2c ppp2ca ppp2caa ppp2cb ppp2r1b ppp2r1bb ppp2r5c ppp2r5cb rac1 rac1a rac2 rhog rhogb si:ch211-227n20.1 si:dkey-21e2.2 si:dkey-241l7.9 si:dkeyp-74c5.3 sparse src strn tdsubc_2h3 wu:fa11a11 wu:fb05c08 wu:fb16a12 wu:fb17h07 wu:fb18e12 wu:fb34e06 wu:fb38a08 wu:fb65b05 wu:fc05c02 wu:fc32c12 wu:fc89b01 wu:fd11d03 wu:fd16e02 wu:fi06b09 wu:fk24a01 wu:fk30f01 wu:fk56b03 wu:fv70f10 xx:tdsubc_2h3 zERK1 zERK2 zfER-beta2 zfER[b]2 zgc:103549 zgc:109774 zgc:110576 zgc:110641 zgc:153249 zgc:194535 zgc:194746 zgc:194777 zgc:55808 zgc:55823 zgc:55848 zgc:55917 zgc:63473 zgc:63601 zgc:73077 zgc:73230 zgc:77172 zgc:86686 zgc:86934 zgc:92493	Danio rerio (zebrafish)
PI3K/AKT activation	Rho-related GTP-binding protein RhoA-C	Q7T2E8	rhoac	Danio rerio (zebrafish)
PI3K/AKT Signaling	3-phosphoinositide-dependent protein kinase 1 Betacellulin, epidermal growth factor family member Epigen Esr2a protein Estrogen receptor Fgf23 Fibroblast growth factor 17 Fibroblast growth factor 3 Fibroblast growth factor 8 Fibroblast growth factor receptor 1-A Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2a Kit ligand Klotho Mast/stem cell growth factor receptor kita Neuregulin 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphoinositide 3-kinase adapter protein 1 Phosphoinositide-3-kinase, regulatory subunit 3A (gamma) Platelet-derived growth factor receptor alpha Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Putative fibroblast growth factor 1 Rac family small GTPase 2 Ras homolog family member Gb Ras-related C3 botulinum toxin substrate 1 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Serine/threonine-protein kinase Sgk1 Striatin non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A0R4INZ6 A0A0R4IUJ2 A0A0R4IWG0 A0A2R8Q0D8 A1L1U1 A9JRW9 B0S6V7 B3DGE3 B3DHG9 B8LFF6 E7EXT6 E7F251 E7FGA4 F1QAD7 F1QIR0 F1RC43 O57341 P48802 P57717 Q08CD2 Q1JPZ3 Q1XG76 Q38PL0 Q56JH6 Q5EBY4 Q5G254 Q5MK87 Q5RKN6 Q5TLE1 Q5TLE2 Q6IQN5 Q6NZV1 Q6PBT8 Q6PC73 Q6SJP8 Q7SYE7 Q7SZF7 Q7ZSZ9 Q7ZTW4 Q7ZU32 Q803F2 Q8AY90 Q8JFR5 Q8UUX0 Q90Z00 Q9DE49 Q9DFC9	ARHG EGFR12 EGFR15 ER[b]2 ER[b]a NRG2b akt2 akt3b btc cb945 dob egfr egfra epgn erbb2 erbb3 erbb3b erbb4 erbb4a erbeta2 esr esr1 esr2a fb18e12 fc89b01 fgf-1 fgf-10 fgf-3 fgf-8 fgf1 fgf10 fgf10a fgf17 fgf17b fgf2 fgf20a fgf22 fgf23 fgf3 fgf4 fgf5 fgf6b fgf8 fgf8a fgfr1 fgfr1a grb2 grb2a grb2b hbegfa id:ibd5158 kit kita kitla kitlga kl nr3a1 nrg2b pdgfab pdgfbb pdgfra pdpk1b pik3ap1 pik3ca pik3cb pik3cd pik3r1 pik3r2 pik3r3a rac1 rac1a rac2 rhog rhogb sgk sgk1 si:ch211-227n20.1 si:dkey-21e2.2 si:dkeyp-74c5.3 sparse src strn wu:fb05c08 wu:fb16a12 wu:fb18e12 wu:fb34e06 wu:fb65b05 wu:fc32c12 wu:fc89b01 wu:fd11d03 wu:fd16e02 wu:fk30f01 wu:fk56b03 wu:fv70f10 zfER-beta2 zfER[b]2 zgc:103549 zgc:109774 zgc:153249 zgc:194535 zgc:55823 zgc:55848 zgc:55917 zgc:63473 zgc:63601 zgc:73077 zgc:73230 zgc:77318 zgc:86686 zgc:86934	Danio rerio (zebrafish)
PI-3K cascade:FGFR1	Fgf23 Fibroblast growth factor 17 Fibroblast growth factor 3 Fibroblast growth factor 8 Fibroblast growth factor receptor 1-A Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2a Klotho Phosphatidylinositol 3-kinase regulatory subunit alpha Putative fibroblast growth factor 1 phosphatidylinositol-4,5-bisphosphate 3-kinase	B0S6V7 B3DGE3 F1QAD7 F1RC43 O57341 P48802 Q1XG76 Q38PL0 Q5MK87 Q5RKN6 Q5TLE1 Q5TLE2 Q6PBT8 Q6PC73 Q6SJP8 Q8AY90 Q90Z00 Q9DFC9	dob fb18e12 fc89b01 fgf-1 fgf-10 fgf-3 fgf-8 fgf1 fgf10 fgf10a fgf17 fgf17b fgf2 fgf20a fgf22 fgf23 fgf3 fgf4 fgf5 fgf6b fgf8 fgf8a fgfr1 fgfr1a grb2 grb2a grb2b id:ibd5158 kl pik3ca pik3r1 si:dkey-21e2.2 si:dkeyp-74c5.3 wu:fb05c08 wu:fb18e12 wu:fb34e06 wu:fb65b05 wu:fc89b01 wu:fd11d03 zgc:103549 zgc:109774 zgc:194535 zgc:73077	Danio rerio (zebrafish)
PI Metabolism	Tumor necrosis factor alpha-induced protein 8-like protein 1 Tumor necrosis factor alpha-induced protein 8-like protein 3 Tumor necrosis factor, alpha-induced protein 8-like protein 2 B	Q7SZE8 Q7T364 Q7T3D0	tnfaip8 tnfaip8l tnfaip8l1 tnfaip8l2 tnfaip8l2b tnfaip8l3	Danio rerio (zebrafish)
PCP/CE pathway	Disheveled-associated activator of morphogenesis 1 Dishevelled, dsh homolog 2 (Drosophila) Frizzled 7b Frizzled class receptor 3b Frizzled-1 Frizzled-6 Profilin Profilin Profilin Protein Wnt-1 Protein Wnt-4a Protein Wnt-5b Protein Wnt Rac family small GTPase 2 Rac family small GTPase 3a Rac family small GTPase 3b Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoA-C	A0JBX4 A1BPR0 A9JRY8 B3DJ49 E7F0A1 P24257 P47793 Q5RHJ3 Q6AZA1 Q6DGB7 Q6IQN5 Q6P0Y7 Q7T2E8 Q7ZSZ9 Q802D5 Q803Q5 Q90ZT3 Q92050	daam1b daam1l dvl2 fa91a03 fc83b10 frizzled3b fz10 fz3 fz7 fzd1 fzd3b fzd3l fzd6 fzd7a hm:zeh0341 id:ibd2735 int-1 pfn1 pfn2 pfn2a pfn2b pfn2l rac1 rac1a rac2 rac3 rac3a rac3b rhoac sb:cb813 sb:eu471 si:ch211-87i20.1 wnt-1 wnt-4 wnt-5 wnt1 wnt4 wnt4a wnt5 wnt5a wnt5b wu:fa91a03 wu:fb01g08 wu:fb02e10 wu:fb54f09 wu:fb95b01 wu:fc05d12 wu:fc17e10 wu:fc83b10 wu:fd16e02 wu:fd58f06 wu:fi35b08 wu:fo71e09 wu:fp54a02 zg03 zg07 zg10 zgc:100831 zgc:194774 zgc:55372 zgc:55823 zgc:55917 zgc:65879 zgc:77440 zgc:86686 zgc:86790 zgc:86934	Danio rerio (zebrafish)
Oxidative Stress Induced Senescence	Cellular tumor antigen p53 Chromobox homolog 7a Chromobox homolog 8b Chromobox protein homolog 2 Dual specificity mitogen-activated protein kinase kinase 6 E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase RING2 Histone H2A.V Histone H2A Histone H2A Histone H2A Histone H2B 1/2 Histone H2B 3 Histone H2B Histone H2B Histone H2B Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 MAP kinase-activated protein kinase 5 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14B Mitogen-activated protein kinase 8 Mitogen-activated protein kinase Mitogen-activated protein kinase Polycomb complex protein BMI-1-A Polycomb protein eed Polycomb protein suz12-B Polyhomeotic-like protein 2 Protein Mdm4 Protein c-Fos Transcription factor Jun Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein LOC100126107 mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase	A1A5X1 A3KPR4 A7E2M8 A7MCA8 B0R1D5 B1NA68 B3DJF8 D6RRB7 O42354 P79734 Q08BS4 Q0Z946 Q3B7P7 Q4QRF4 Q502N4 Q566T0 Q568R0 Q5BJA5 Q5XJK2 Q6DHN7 Q6IQ84 Q6NZT5 Q6P0S4 Q6P3H7 Q6PC60 Q6PI20 Q71PD7 Q7SXA3 Q7T2F2 Q7ZTT0 Q7ZTY4 Q7ZUW7 Q7ZVK8 Q7ZW72 Q803I4 Q8JIQ9 Q8JIR0 Q8QHL5 Q9DGD9 Q9DGE0 Q9DGE1 R4GE15	ERK1 LOC100150038 LOC100329358 LOC100331412 LOC100332229 LOC103908680 LOC108181627 LOC562770 LOC570661 LOC794549 MKK4 MKK4A-l MKK7 bmi1 bmi1a c-Jun cb1065 cbx2 cbx7a cbx8b drp53 edr2 eed ezh2 fi06b09 fj36h07 fos fosab h2af1al h2afvb h2afvl h2afx1 h2afza h2av h2ax1 h2az2a h2az2b h3-5 h3f3a h3f3b.1 h3f3c h3f3d hist2h2l hm:zeh0386 ik:tdsubc_1f2 im:6896397 im:7138386 jnk1 jun map2k3 map2k4 map2k4A map2k4a map2k6 map2k7 mapk1 mapk11 mapk14 mapk14b mapk3 mapk8 mapkapk2 mapkapk2a mapkapk3 mapkapk5 mdm2 mdm4 mdmx pc1 pcgf4a ph2 phc2 psc1 rbb4 rbb4l rbbp4 rbbp7 ring1b rnf2 rps27a si:ch211-113a14.17 si:ch211-113a14.29 si:ch211-113a14.6 si:ch211-254d18.2 si:ch73-36p18.4 si:dkey-108k21.12 si:dkey-108k21.18 si:dkey-108k21.28 si:dkey-23a13.7 suz12 suz12b tdsubc_1f2 tp53 uba52 wu:fa91f08 wu:fb30e10 wu:fc56c10 wu:fd20e09 wu:fi03a01 wu:fi06b09 wu:fj36h07 xx:tdsubc_1f2 zERK1 zERK2 zgc:103563 zgc:110152 zgc:111978 zgc:112234 zgc:113984 zgc:123344 zgc:136500 zgc:152758 zgc:158342 zgc:173585 zgc:173587 zgc:194998 zgc:56685 zgc:65863 zgc:66168 zgc:77885 zgc:86905 zgc:92197	Danio rerio (zebrafish)
Ovarian tumor domain proteases	Cellular tumor antigen p53 E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase RNF128 precursor Estrogen receptor Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Rho-related GTP-binding protein RhoA-C TNF receptor-associated factor 6 TNF receptor-associated factor Transitional endoplasmic reticulum ATPase Ubiquitin thioesterase OTU1 Ubiquitin thioesterase zranb1-B Ubiquitin thioesterase ubiquitinyl hydrolase 1	A0JMQ9 P57717 P79734 Q567B1 Q6DEG0 Q6DH16 Q6IWL4 Q6NW80 Q6NX00 Q6PC58 Q7T2E8 Q7ZU99 Q7ZZ56	cdc48 drp53 esr esr1 fa11a08 fb17f04 fb73f10 fc83f12 fd16b10 fk90e11 nr3a1 otub1a otub1l otud3 pten ptenb rhoac rnf128 rnf128a si:bz1g13.4 tp53 traf3 traf6 ube2d1 ube2d1b vcp wu:fa11a08 wu:fb17f04 wu:fb57h05 wu:fb73f10 wu:fc16h06 wu:fc83f12 wu:fd16b10 wu:fk90e11 yod1 zgc:73096 zgc:77843 zgc:85911 zgc:92367 zgc:92685 zranb1 zranb1b	Danio rerio (zebrafish)
Other interleukin signaling	Alpha-taxilin Colony-stimulating factor 1b (macrophage) Interleukin 34 Macrophage colony-stimulating factor 1 receptor Placental syntaxin 4A	A5D6U5 B0UYR0 B3DLJ8 Q7ZV18 Q9I8N6	IL-34 STX4A csf1-2 csf1b csf1r fc21b12 fms il34 im:7039434 si:ch211-239j19.3 si:dkey-220f10.3 stx4 txlna wu:fc08c10 wu:fc21b12 zgc:158436 zgc:56272	Danio rerio (zebrafish)
Organic anion transporters	Mitochondrial 2-oxoglutarate/malate carrier protein Mitochondrial dicarboxylate carrier Mitochondrial glutamate carrier 1 Sialin Slc5a5 protein Sodium-coupled monocarboxylate transporter 1 Solute carrier family 25 (Mitochondrial carrier Solute carrier family 25 member 55b Tricarboxylate transport protein B, mitochondrial Vesicular glutamate transporter 1 Vesicular glutamate transporter 2.1 Vesicular glutamate transporter 3	A3QK31 A4IG60 E7F2B8 F1R4U0 Q08CH2 Q1L8X9 Q3ZMH1 Q5W8I8 Q6DHS4 Q6IQ89 Q7ZTT6 Q7ZWA7	MGC163045 blu cb229 fa07h09 sb:cb229 sb:cb809 si:ch211-200a16.4 slc17a5 slc17a6 slc17a6b slc17a7 slc17a7a slc17a8 slc25a10 slc25a10b slc25a11 slc25a18 slc25a1b slc25a22 slc25a55a slc25a55b slc5a5 slc5a8 slc5a8l smcte vglut1 vglut2.1 vglut2a vglut3 wu:fa07h09 wu:fa12h05 wu:fb72h03 zgc:153077 zgc:56592 zgc:56614 zgc:86898	Danio rerio (zebrafish)
Opsins	Encephalopsin Melanopsin-A Opsin-1, short-wave-sensitive 1 Opsin-5 RPE-retinal G protein-coupled receptor Red-sensitive opsin-1 Red-sensitive opsin-2 Retinal pigment epithelium rhodopsin homolog/peropsin Rhodopsin	A9NJI7 E6P6L8 P35359 Q2KNE5 Q567Y2 Q66I55 Q8AYN0 Q9W6A7 Q9W6A9	Opn5m lws1 lws2 opn1lw1 opn1lw2 opn1sw1 opn1sw2 opn3 opn4 opn4a opn4d opn4m1 opn5 rdops rgr rgr1 rgra rho rrh si:ch211-105n9.2 sws1 uvops zfo2 zgc:103757 zgc:110660	Danio rerio (zebrafish)
Oleoyl-phe metabolism	N-fatty-acyl-amino acid synthase/hydrolase PM20D1.2	Q08BB2	pm20d1.2	Danio rerio (zebrafish)

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