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CBM13
Summary
- Family
- Carbohydrate-Binding Module Family 13
- CAZy
- Activities
- Modules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
Protein List
| UniProt ID | Protein Name | GenBank | Gene ID | Enzyme | Organism |
|---|---|---|---|---|---|
| A4Y738 | Alpha-N-arabinofuranosidase |
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| E5D8G1 | Polypeptide N-acetylgalactosaminyltransferase |
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| Q9RDQ1 | Putative secreted protein |
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| B3KT16 | Polypeptide N-acetylgalactosaminyltransferase |
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| Q9L153 | Putative secreted protein |
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| Q9K474 | Putative secreted glycosyl hydrolase |
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| A0A0M5J3I3 | Polypeptide N-acetylgalactosaminyltransferase |
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| A0A7D6FIC3 | Hydrogenase expression protein |
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| Q49A17 | Polypeptide N-acetylgalactosaminyltransferase-like 6 |
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| Q05BM8 | Polypeptide N-acetylgalactosaminyltransferase |
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| A0A0K1IYI1 | Glycoside hydrolase family 43 |
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| Q6IS24 | Polypeptide N-acetylgalactosaminyltransferase 17 |
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| Q97LI4 | Endo-arabinase related enzyme (Family 43 glycosyl hydrolase domain and ricin B-like domain) |
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| C5CYC7 | Ricin B lectin |
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| B1VQ95 | Putative secreted hydrolase |
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| A0A8B0EWU1 | Ricin-type beta-trefoil lectin domain protein |
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| Q8N4A0 | Polypeptide N-acetylgalactosaminyltransferase 4 |
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| Q925R7 | Polypeptide N-acetylgalactosaminyltransferase 10 |
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| Q8IXK2 | Polypeptide N-acetylgalactosaminyltransferase 12 |
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| A0A1S5W9E3 | Mannan endo-1,4-beta-mannosidase |
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| Q7K755 | Putative polypeptide N-acetylgalactosaminyltransferase 11 |
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| Q6WV17 | Polypeptide N-acetylgalactosaminyltransferase 5 |
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| A0A0H2WB70 | Lectin repeat domain protein |
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| J9VEF7 | Ricin B-type lectin domain-containing protein |
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| A0A8A7JFF3 | Ricin-type beta-trefoil lectin domain protein |
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