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Lambert-Eaton myasthenic syndrome
Summary
- Synonym
-
- Eaton-Lambert syndrome
- LEMS
- Lambert-Eaton syndrome
- Definition
- A neuromuscular junction disease that is characterized by an abnormality of acetylcholine (ACh) release at the neuromuscular junction which results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal.
- Super Class
- autoimmune disease of musculoskeletal system autoimmune disease of peripheral nervous system neuromuscular junction disease
External Links
- Disease Ontology
- DOID:0050214
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- MGI genotype (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 43 | ACHE | acetylcholinesterase (Yt blood group) | |
| 1103 | CHAT | choline O-acetyltransferase | |
| 1798 | DPAGT1 | dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | |
| 3383 | ICAM1 | intercellular adhesion molecule 1 | |
| 4680 | CEACAM6 | CEA cell adhesion molecule 6 | |
| 5728 | PTEN | phosphatase and tensin homolog | |
| 29925 | GMPPB | GDP-mannose pyrophosphorylase B |
Related Glycoprotein
