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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Summary

Gene Symbol

PFKFB1

Organism

Monodelphis domestica (gray short-tailed opossum)

External Links

NCBI Gene: 100014887
KEGG Gene ID: mdo:100014887
PubChem: 100014887

Annotation

Keyword

Kinase
Multifunctional enzyme
Nucleotide-binding
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A5F8GVT7
K7E1I7
F6SPM4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
fructose metabolic process	IEA	22301074
fructose 2,6-bisphosphate metabolic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

carbohydrate derivative metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	IEA	30032202
cytosol	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex

cellular anatomical entity [inference]

cytosol

Displaying **all 3** entries
GO Term	Evidence Code	PMID
6-phosphofructo-2-kinase activity	IEA	22301074 30032202
fructose-2,6-bisphosphate 2-phosphatase activity	IEA	30032202
ATP binding	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose-2,6-bisphosphate 2-phosphatase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

6-phosphofructo-2-kinase/fructose-2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 7** entries
Gene Ontology
6-phosphofructo-2-kinase activity
ATP binding
carbohydrate phosphorylation
catalytic activity
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
nucleotide binding

Displaying **all 6** entries
InterPro
6-phosphofructo-2-kinase
Fructose-2,6-bisphosphatase
Histidine phosphatase superfamily, clade-1
Histidine phosphatase superfamily
P-loop containing nucleoside triphosphate hydrolase
Phosphoglycerate/bisphosphoglycerate mutase, active site

KEGG BRITE Database

Orthology

K19028

Name

6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 [EC:2.7.1.105 3.1.3.46]

References

8814283

Ortholog

Displaying entries **1 - 10** of 59 in total

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Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5207			HUMAN100885
Mus musculus	18639			MOUSE64758
Rattus norvegicus	24638			RATNO44230
Pan troglodytes	465657			PANTR46096
Canis lupus familiaris	491903			CANLF19813
Macaca mulatta	701969			MACMU48566
Ornithorhynchus anatinus	100078789			ORNAN23558
Sus scrofa	100233197			PIGXX37392
Oryctolagus cuniculus	100345023			RABIT13526
Callithrix jacchus	100412706			CALJA48448

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 9, 2024