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cytochrome P450, family 11, subfamily A, polypeptide 1

Summary

Gene Symbol

CYP11A1

Organism

Ovis aries (sheep)

External Links

NCBI Gene: 100048994
KEGG Gene ID: oas:100048994
PubChem: 100048994

Annotation

Keyword

Cholesterol metabolism
Direct protein sequencing
Heme
Mitochondrion inner membrane
Monooxygenase
Reference proteome
Steroidogenesis
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P79202	CYPXIA1 Cholesterol desmolase Cytochrome P450 11A1 Cytochrome P450(scc)

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cellular response to peptide hormone stimulus	IEA	30032202
C21-steroid hormone biosynthetic process	IEA	30032202
glucocorticoid biosynthetic process	IEA	30032202
cortisol metabolic process	IEA	30032202
cholesterol metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

cellular biosynthetic process [inference]

C21-steroid hormone biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

cortisol metabolic process

cellular biosynthetic process [inference]

C21-steroid hormone biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

glucocorticoid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

cortisol metabolic process

tertiary alcohol metabolic process [inference]

cortisol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cellular ketone metabolic process [inference]

cortisol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

glucocorticoid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

cellular ketone metabolic process [inference]

cortisol metabolic process

olefinic compound metabolic process [inference]

cortisol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

glucocorticoid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

cortisol metabolic process

tertiary alcohol metabolic process [inference]

cortisol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

cortisol metabolic process

cellular biosynthetic process [inference]

C21-steroid hormone biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	22301074
monooxygenase activity	IEA	22301074
iron ion binding	IEA	22301074
heme binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00498

Name

cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]

References

Rhea

RHEA:35739

H⁺ + O₂ + cholesterol

H₂O + pregnenolone + 4-methylpentanal

Enzyme

1.14.15.6

PMID

Ortholog

Displaying entries **71 - 80** of 82 in total

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Species	Gene ID	Orthologous MAtrix
Chelonoidis abingdonii	116821105	CHEAB25882
Echeneis naucrates	115056007	ECHNA54582
Salarias fasciatus	115392075	SALFA29498
Athene cunicularia	113483867	ATHCN13850
Colobus angolensis palliatus	105505172	COLAP21119
Propithecus coquereli	105807291	PROCO17637
Cyprinus carpio carpio	109044858	CYPCA142881
Cyprinus carpio carpio	109082245	CYPCA141025
Nannospalax galili	103736867	NANGA00196
Corvus moneduloides	116450660	CORMO02769