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abl interactor 1

Summary

Gene Symbol

ABI1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10006

PubChem

10006

Alliance of Genome Resources

HGNC:11320

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell projection
Chromosomal rearrangement
Coiled coil
Cytoskeleton
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
SH3 domain
Synapse

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B6VEX3
B6VEX5
B6VEX4
Q8IZP0	Abelson interactor 1 Abl-binding protein 4 Eps8 SH3 domain-binding protein Nap1-binding protein Spectrin SH3 domain-binding protein 1 e3B1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
actin polymerization or depolymerization	NAS	11516653
neuron migration	IBA
megakaryocyte development	IEA
lamellipodium morphogenesis	IEA
negative regulation of cell population proliferation	TAS	9010225

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cell motility [inference]

cell migration [inference]

neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

lamellipodium morphogenesis

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium morphogenesis

supramolecular fiber organization [inference]

actin filament organization [inference]

actin polymerization or depolymerization

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

somitogenesis

segmentation [inference]

somitogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

lamellipodium morphogenesis

anatomical structure formation involved in morphogenesis [inference]

somitogenesis

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

positive regulation of protein tyrosine kinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
filopodium tip	IDA	11516653
postsynaptic density	IEA
actin-based cell projection	IBA
lamellipodium	IBA IDA	11516653 17101133
endoplasmic reticulum	TAS	9593709

GO Hierarchy

cellular component

protein-containing complex [inference]

SCAR complex

cellular anatomical entity [inference]

cytosol

site of polarized growth [inference]

growth cone

filopodium tip

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynaptic specialization [inference]

postsynaptic density

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11418237 12681507 14565974 15289329 16417406 17101133 17395426 18328268 20598684 21078624 21173240 21320496 26496610 31980649 32296183 33961781 35271311 9010225 9593709
protein tyrosine kinase activator activity	ISS
SH3 domain binding	IBA IPI	19798448
signaling adaptor activity	IBA IDA ISS	17101133
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding

protein domain specific binding [inference]

SH3 domain binding

cell adhesion molecule binding [inference]

cadherin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Abl interactor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
actin cortical patch localization
lipid binding
plasma membrane tubulation

Displaying **all 2** entries
InterPro
SH3 domain
SH3-like domain superfamily

Ortholog

Displaying entries **81 - 87** of 87 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Chelonoidis abingdonii	116828166		CHEAB13107
Rhinolophus ferrumequinum	117019153		RHIFE33204
Scophthalmus maximus	118290910		SCOMX18757
Balaenoptera musculus	118890356		BALMU28919
Panthera leo	122223991		PANLE18440
Ursus americanus	123778142		URSAM10339
Pongo pygmaeus	129006671	9600_0:002845

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements