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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
potassium voltage-gated channel subfamily E regulatory subunit 3
Summary
- Gene Symbol
-
- KCNE3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Brugada syndrome
- Cell membrane
- Cell projection
- Cytoplasm
- Disease variant
- Glycoprotein
- Potassium channel
- Reference proteome
- Transmembrane helix
- Voltage-gated channel
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| potassium ion export across plasma membrane | ||
| sodium ion transport | ||
| membrane repolarization during ventricular cardiac muscle cell action potential | ||
| regulation of heart rate by cardiac conduction | ||
| negative regulation of delayed rectifier potassium channel activity |
GO Hierarchy
biological process
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of localization [inference]
regulation of transport [inference]
regulation of transmembrane transport [inference]
regulation of transmembrane transporter activity [inference]
negative regulation of transmembrane transport [inference]
regulation of monoatomic ion transmembrane transport [inference]
regulation of monoatomic ion transport [inference]
regulation of metal ion transport [inference]
regulation of monoatomic ion transmembrane transport [inference]
negative regulation of monoatomic ion transport [inference]
negative regulation of transport [inference]
negative regulation of biological process [inference]
regulation of cellular process [inference]
regulation of transmembrane transport [inference]
regulation of transmembrane transporter activity [inference]
negative regulation of transmembrane transport [inference]
regulation of monoatomic ion transmembrane transport [inference]
negative regulation of cellular process [inference]
regulation of membrane repolarization [inference]
regulation of biological quality [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| voltage-gated potassium channel complex | ||
| perikaryon | ||
| neuronal cell body membrane | ||
| plasma membrane | ||
| membrane raft |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| delayed rectifier potassium channel activity | ||
| potassium channel regulator activity | ||
| voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization | ||
| transmembrane transporter binding |
GO Hierarchy
molecular function
transporter activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- potassium voltage-gated channel subfamily e member 3
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Potassium channel, voltage-dependent, beta subunit, KCNE |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110223 | Brugada syndrome 6 | |
| DOID:14452 | hypokalemic periodic paralysis |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 57442 | MGI:1891124 | MOUSE55298 | ||
| 63883 | RGD:621384 | |||
| 397168 | PIGXX34987 | |||
| 398416 | Xenbase:XB-GENE-5887246 | |||
| 466706 | 9598_0:00301e | PANTR03818 | ||
| 485197 | CANLF08273 | |||
| 527762 | BOVIN07227 | |||
| 718902 | MACMU11455 | |||
| 100011476 | MONDO24590 | |||
| 100065199 | HORSE38072 |
