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C-X-C motif chemokine receptor 4

Summary

Gene Symbol

CXCR4

Organism

Papio anubis (olive baboon)

External Links

NCBI Gene: 100126711
PubChem: 100126711

Annotation

Keyword

Cell junction
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Isopeptide bond
Lysosome
Phosphoprotein
Proteoglycan
Reference proteome
Sulfation
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P56491	Fusin Stromal cell-derived factor 1 receptor

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
chemotaxis	IEA	22301074
brain development	IEA	30032202
calcium-mediated signaling
cell chemotaxis
cellular response to cytokine stimulus

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

locomotion [inference]

taxis [inference]

cell chemotaxis

response to stimulus [inference]

immune response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

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GO Term	Evidence Code	PMID
external side of plasma membrane
membrane	IEA	22301074
early endosome
anchoring junction
late endosome

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

cell junction [inference]

anchoring junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

side of membrane [inference]

external side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
C-X-C motif chemokine 12 receptor activity
chemokine receptor activity	IEA	22301074
C-C chemokine receptor activity
C-C chemokine binding
cytokine binding	IEA	22301074

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Cercopithecoidea

Group Name

C-X-C chemokine receptor type 4

Functional Category

K: Transcription
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

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Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
brain development
calcium-mediated signaling
cell chemotaxis
chemokine receptor activity
chemokine-mediated signaling pathway
chemotaxis
immune response
neurogenesis

Displaying **all 5** entries
InterPro
CXC chemokine receptor 4 N-terminal domain
CXC chemokine receptor 4/atypical chemokine receptor 2
Chemokine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7852			HUMAN64856
Mus musculus	12767			MOUSE28321
Rattus norvegicus	60628			RATNO06450
Danio rerio	114447			DANRE45348
Danio rerio	140747			DANRE38061
Bos taurus	281736			BOVIN24353
Sus scrofa	396659			PIGXX08843
Ovis aries	443532			SHEEP09537
Pan troglodytes	450130			PANTR28757
Canis lupus familiaris	483900			CANLF06383

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 9, 2024