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C-X-C motif chemokine receptor 4

Summary

Gene Symbol

CXCR4

Organism

Papio anubis (olive baboon)

External Links

NCBI Gene: 100126711
PubChem: 100126711

Annotation

Keyword

Cell junction
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Isopeptide bond
Lysosome
Phosphoprotein
Proteoglycan
Reference proteome
Sulfation
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P56491	Fusin Stromal cell-derived factor 1 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
chemotaxis	IEA	22301074
brain development	IEA	30032202
calcium-mediated signaling
cell chemotaxis
cellular response to cytokine stimulus

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

locomotion [inference]

taxis [inference]

cell chemotaxis

response to stimulus [inference]

immune response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane
membrane	IEA	22301074
early endosome
anchoring junction
late endosome

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

cell junction [inference]

anchoring junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

side of membrane [inference]

external side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
C-X-C motif chemokine 12 receptor activity
chemokine receptor activity	IEA	22301074
C-C chemokine receptor activity
C-C chemokine binding
cytokine binding	IEA	22301074

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Cercopithecoidea

Group Name

C-X-C chemokine receptor type 4

Functional Category

K: Transcription
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

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Gene Ontology
positive regulation of cytosolic calcium ion concentration

Displaying **all 5** entries
InterPro
CXC chemokine receptor 4 N-terminal domain
CXC chemokine receptor 4/atypical chemokine receptor 2
Chemokine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **51 - 60** of 98 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103180391			CALMI20283
Chlorocebus sabaeus	103216995	60711_0:003c94		CHLSB01272
Ursus maritimus	103667676			URSMA16259
Serinus canaria	103814274			SERCA06531
Rhinopithecus roxellana	104668781	61622_0:003969		RHIRO34056
Pteropus vampyrus	105288337			PTEVA07340
Macaca nemestrina	105492570	9545_0:001893		MACNE05092
Colobus angolensis palliatus	105508802	336983_0:00108a
Mandrillus leucophaeus	105532190	9568_0:004d3e		MANLE08123
Cercocebus atys	105590357			CERAT30159

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024