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histone deacetylase 6
Summary
- Gene Symbol
-
- HDAC6
- Aliases
-
- FLJ16239
- HD6
- JM21
- KIAA0901
- PPP1R90
- protein phosphatase 1, regulatory subunit 90
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Actin-binding
- Alternative splicing
- Autophagy
- Cell projection
- Chromatin regulator
- Cytoskeleton
- Hydrolase
- Methylation
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repeat
- Repressor
- Transcription regulation
- Transferase
- Ubl conjugation
- Ubl conjugation pathway
- Zinc-finger
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein polyubiquitination | ||
| response to amphetamine | ||
| protein deacetylation | ||
| protein quality control for misfolded or incompletely synthesized proteins | ||
| intracellular protein transport |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of growth [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of microtubule-based process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| histone deacetylase complex | ||
| histone deacetylase complex | ||
| nucleus | ||
| nucleoplasm | ||
| cytoplasm |
| GO Term | Evidence Code | PMID |
|---|---|---|
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| transcription corepressor binding | ||
| actin binding | ||
| histone deacetylase activity | ||
| histone deacetylase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- histone deacetylase 6
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| histone deacetylase activity |
| zinc ion binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0112106 | chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000154 | Wide mouth |
| HP:0000238 | Hydrocephalus |
| HP:0000256 | Macrocephaly |
| HP:0000322 | Short philtrum |
| HP:0000347 | Micrognathia |
| HP:0000369 | Low-set ears |
| HP:0000457 | Depressed nasal ridge |
| HP:0000568 | Microphthalmia |
| HP:0000878 | 11 pairs of ribs |
| HP:0000883 | Thin ribs |
| Disease ID | Disease Name |
|---|---|
| ORPHA:163966 |
|
| OMIM:300863 |
|
