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cadherin 3

Summary

Gene Symbol

CDH3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1001

PubChem

1001

Alliance of Genome Resources

HGNC:1762

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Disease variant
Ectodermal dysplasia
Glycoprotein
Hypotrichosis
Metal-binding
Reference proteome
Repeat
Signal
Transmembrane helix
Vision

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DLF0
P22223	Placental cadherin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 22 in total

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GO Term	Evidence Code	PMID
cell migration	IBA
positive regulation of gene expression	IMP	23334344
positive regulation of insulin-like growth factor receptor signaling pathway	IMP	22696062
retina homeostasis	IMP	23143461
positive regulation of melanin biosynthetic process	IMP	23334344

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

cell-cell adhesion mediated by cadherin

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell-cell junction organization [inference]

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

molting cycle process [inference]

hair cycle process

keratinization

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

retina homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

retina homeostasis

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of secondary metabolic process [inference]

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of insulin-like growth factor receptor signaling pathway [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of melanosome transport

regulation of melanosome transport [inference]

positive regulation of melanosome transport

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of melanosome transport

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of transport [inference]

positive regulation of melanosome transport

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of developmental process [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

negative regulation of multicellular organismal process [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of insulin-like growth factor receptor signaling pathway [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of developmental process [inference]

regulation of hair follicle maturation [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of timing of catagen [inference]

negative regulation of timing of catagen

negative regulation of developmental process [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of multicellular organismal development [inference]

regulation of hair follicle development [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of insulin-like growth factor receptor signaling pathway [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

regulation of epithelial cell proliferation [inference]

regulation of keratinocyte proliferation [inference]

positive regulation of keratinocyte proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of melanosome transport

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of melanosome transport [inference]

positive regulation of melanosome transport

regulation of multicellular organismal process [inference]

regulation of hair cycle [inference]

regulation of hair follicle development [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of hair follicle maturation [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of timing of catagen [inference]

negative regulation of timing of catagen

negative regulation of multicellular organismal process [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of multicellular organismal development [inference]

regulation of hair follicle development [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of tyrosinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of tyrosinase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of tyrosinase activity

regulation of tyrosinase activity [inference]

positive regulation of tyrosinase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of tyrosinase activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cell junction	IDA
plasma membrane	IDA TAS	10460003
adherens junction	IBA
catenin complex	IBA
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
beta-catenin binding	IBA
calcium ion binding	IEA
molecular_function	ND
cadherin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

beta-catenin binding

cell adhesion molecule binding [inference]

cadherin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cadherin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
adherens junction organization
cadherin binding
calcium ion binding
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell adhesion mediated by cadherin
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 6** entries
InterPro
Cadherin conserved site
Cadherin, Y-type LIR-motif
Cadherin-like superfamily
Cadherin-like
Cadherin
Catenin binding domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110711	congenital hypotrichosis with juvenile macular dystrophy	Alliance of Genome Resources
DOID:0111649	ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 56 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Cricetulus griseus	100758473		CRIGR12557
Sarcophilus harrisii	100919995		SARHA05060
Otolemur garnettii	100964505		OTOGA03869
Pan paniscus	100982523	9597_0:004051	PANPA15506
Papio anubis	101005260		PAPAN15304
Saimiri boliviensis boliviensis	101041999		SAIBB26657
Felis catus	101094895		FELCA34546
Ovis aries	101111652		SHEEP05161
Gorilla gorilla gorilla	101143945	9595_0:0045dc	GORGO11526
Octodon degus	101575109		OCTDE03524

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements