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cadherin 3

Summary

Gene Symbol

CDH3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1001

PubChem

1001

Alliance of Genome Resources

HGNC:1762

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Disease variant
Ectodermal dysplasia
Glycoprotein
Hypotrichosis
Metal-binding
Reference proteome
Repeat
Signal
Transmembrane helix
Vision

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DLF0
P22223	Placental cadherin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IBA
retina homeostasis	IMP	23143461
cell-cell junction assembly	IBA
cell adhesion	TAS	2793940
homophilic cell adhesion via plasma membrane adhesion molecules	IEA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

cell-cell adhesion mediated by cadherin

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell-cell junction organization [inference]

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

molting cycle process [inference]

hair cycle process

keratinization

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

retina homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

retina homeostasis

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of secondary metabolic process [inference]

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of insulin-like growth factor receptor signaling pathway [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of melanosome transport

regulation of melanosome transport [inference]

positive regulation of melanosome transport

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of melanosome transport

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of transport [inference]

positive regulation of melanosome transport

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of developmental process [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

negative regulation of multicellular organismal process [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of insulin-like growth factor receptor signaling pathway [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of developmental process [inference]

regulation of hair follicle maturation [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of timing of catagen [inference]

negative regulation of timing of catagen

negative regulation of developmental process [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of multicellular organismal development [inference]

regulation of hair follicle development [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of insulin-like growth factor receptor signaling pathway [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

regulation of epithelial cell proliferation [inference]

regulation of keratinocyte proliferation [inference]

positive regulation of keratinocyte proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of melanin biosynthetic process

positive regulation of melanosome transport

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of melanosome transport [inference]

positive regulation of melanosome transport

regulation of multicellular organismal process [inference]

regulation of hair cycle [inference]

regulation of hair follicle development [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of hair follicle maturation [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of timing of catagen [inference]

negative regulation of timing of catagen

negative regulation of multicellular organismal process [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of multicellular organismal development [inference]

regulation of hair follicle development [inference]

negative regulation of hair follicle development [inference]

negative regulation of hair follicle maturation [inference]

negative regulation of timing of catagen

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of tyrosinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of tyrosinase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of tyrosinase activity

regulation of tyrosinase activity [inference]

positive regulation of tyrosinase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of tyrosinase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	TAS
plasma membrane	IDA	10460003
adherens junction	IBA
catenin complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
beta-catenin binding	IBA
cadherin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

beta-catenin binding

cell adhesion molecule binding [inference]

cadherin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cadherin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
adherens junction organization
cadherin binding
calcium ion binding
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell adhesion mediated by cadherin
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 6** entries
InterPro
Cadherin conserved site
Cadherin, Y-type LIR-motif
Cadherin-like superfamily
Cadherin-like
Cadherin
Catenin binding domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110711	congenital hypotrichosis with juvenile macular dystrophy	Alliance of Genome Resources
DOID:0111649	ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 55 in total

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Species	Gene ID	Orthologous MAtrix
Canis lupus familiaris	611010	CANLF16016
Macaca mulatta	703324	MACMU26343
Monodelphis domestica	100027786	MONDO03553
Equus caballus	100066779	HORSE31135
Oryctolagus cuniculus	100356285	RABIT11010
Callithrix jacchus	100397967	CALJA21585
Pongo abelii	100459959	PONAB10408
Ailuropoda melanoleuca	100476072	AILME08735
Nomascus leucogenys	100595483	NOMLE25777
Loxodonta africana	100659173	LOXAF07406

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements