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glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

Summary

Gene Symbol

Aliases

Uae1
bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Organism

Homo sapiens (human)

External Links

NCBI Gene

10020

HGNC

23657

KEGG Gene ID

hsa:10020

PubChem

10020

Alliance of Genome Resources

HGNC:23657

Annotation

Keyword

3D-structure
ATP-binding
Allosteric enzyme
Alternative splicing
Cytoplasm
Disease variant
Hydrolase
Kinase
Metal-binding
Multifunctional enzyme
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y223	UDP-GlcNAc-2-epimerase/ManAc kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
N-acetylneuraminate biosynthetic process	IMP	14707127
UDP-N-acetylglucosamine metabolic process	IEA
N-acetylglucosamine biosynthetic process	IEA
carbohydrate phosphorylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

amide metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

glucosamine-containing compound biosynthetic process [inference]

N-acetylglucosamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

phosphorus metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate phosphorylation

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate phosphorylation

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

glucosamine-containing compound biosynthetic process [inference]

N-acetylglucosamine biosynthetic process

glucosamine-containing compound metabolic process [inference]

N-acetylglucosamine metabolic process [inference]

N-acetylglucosamine biosynthetic process

glucosamine-containing compound biosynthetic process [inference]

N-acetylglucosamine biosynthetic process

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

carbohydrate derivative biosynthetic process [inference]

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

glucosamine-containing compound biosynthetic process [inference]

N-acetylglucosamine biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

glucosamine-containing compound biosynthetic process [inference]

N-acetylglucosamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

phosphorus metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	ISS TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
UDP-N-acetylglucosamine 2-epimerase activity	IBA IDA IMP TAS	14707127 26980148 2808337
metal ion binding	IEA
ATP binding	IEA
protein binding	IPI	18560563 25416956 31515488
N-acylmannosamine kinase activity	IBA IMP TAS	14707127

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

isomerase activity [inference]

racemase and epimerase activity [inference]

racemase and epimerase activity, acting on carbohydrates and derivatives [inference]

UDP-N-acetylglucosamine 2-epimerase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000159921

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12409

Name

bifunctional UDP-N-acetylglucosamine 2-epimerase / N-acetylmannosamine kinase [EC:3.2.1.183 2.7.1.60]

References

Disease

Disease Ontology

Displaying entries **1 - 10** of **116** in total

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DO ID	Disease Name	Source
DOID:0050328	congenital hypothyroidism	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET
DOID:0050760	X-linked myopathy with excessive autophagy	DisGeNET
DOID:0050847	sleep apnea	DisGeNET
DOID:0050848	obstructive sleep apnea	DisGeNET
DOID:0050881	inclusion body myopathy with Paget disease of bone and frontotemporal dementia	DisGeNET
DOID:0060249	scoliosis	DisGeNET
DOID:0060320	inguinal hernia	DisGeNET
DOID:0060478	Zika fever	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 89 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000023	Inguinal hernia
HP:0000158	Macroglossia
HP:0000218	High palate
HP:0000219	Thin upper lip vermilion
HP:0000256	Macrocephaly
HP:0000280	Coarse facial features
HP:0000286	Epicanthus
HP:0000316	Hypertelorism

Displaying **all 4** entries
Disease ID	Disease Name
ORPHA:3166	sialuria
ORPHA:602	GNE myopathy
OMIM:269921	sialuria
OMIM:605820	GNE myopathy

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103177634		CALMI13458
Latimeria chalumnae	102354276		LATCH04814
Danio rerio	393857	ZFIN:ZDB-GENE-040426-1848
Ictalurus punctatus	108260684		ICTPU23578
Salmo salar	106602595		SALSA24844
Salmo salar	106609886		SALSA40441
Salmo trutta	115191847		SALTR31466
Salmo trutta	115202183		SALTR16691
Gadus morhua	115540831		GADMO41822
Oryzias latipes	101166451		ORYLA19511

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements