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translocase of inner mitochondrial membrane 23

Summary

Gene Symbol

TIMM23

Organism

Homo sapiens (human)

External Links

NCBI Gene

100287932

PubChem

100287932

Alliance of Genome Resources

HGNC:17312

Annotation

Keyword

Mitochondrion inner membrane
Reference proteome
Translocation
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O14925

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein import into mitochondrial matrix	IBA
intracellular protein transport	NAS	10339406
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	IMP	37160114
protein targeting to mitochondrion	TAS	10339406

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

protein transport [inference]

intracellular protein transport

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to mitochondrial depolarisation [inference]

regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of mitophagy in response to mitochondrial depolarization [inference]

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

transmembrane transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

mitochondrial transmembrane transport [inference]

protein import into mitochondrial matrix

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to mitochondrial depolarisation [inference]

regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of mitophagy in response to mitochondrial depolarization [inference]

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

cellular response to stimulus [inference]

cellular response to stress [inference]

response to mitochondrial depolarisation [inference]

regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of mitophagy in response to mitochondrial depolarization [inference]

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

protein transport [inference]

intracellular protein transport

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of localization [inference]

transport [inference]

mitochondrial transport [inference]

mitochondrial transmembrane transport [inference]

protein import into mitochondrial matrix

intracellular transport [inference]

intracellular protein transport

transmembrane transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

mitochondrial transmembrane transport [inference]

protein import into mitochondrial matrix

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

protein transport [inference]

intracellular protein transport

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

protein transport [inference]

intracellular protein transport

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IDA NAS TAS	10339406 14726512 20053669 25997101
mitochondrion	HTP IDA	34800366
mitochondrial intermembrane space	IDA	15044455
TIM23 mitochondrial import inner membrane translocase complex	IBA IDA NAS	10339406 30598479

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

TIM23 mitochondrial import inner membrane translocase complex

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

TIM23 mitochondrial import inner membrane translocase complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15044455 23260140 23263864 32296183 32814053 37160114
protein transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

macromolecule transmembrane transporter activity [inference]

protein transmembrane transporter activity

protein transporter activity [inference]

protein transmembrane transporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mitochondrial import inner membrane translocase subunit

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
protein import into mitochondrial matrix

Displaying 1 entry
InterPro
Tim23-like

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:767	muscular atrophy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	53600		MGI:1858317	MOUSE13756
Rattus norvegicus	54312		RGD:3863	RATNO11804
Caenorhabditis elegans	173041		WB:WBGene00008857
Xenopus laevis	432132		Xenbase:XB-GENE-994540
Pan troglodytes	450456	9598_0:002aca		PANTR00609
Xenopus tropicalis	496463		Xenbase:XB-GENE-994532
Bos taurus	509841			BOVIN22718
Macaca mulatta	709594			MACMU45892
Danio rerio	798429		ZFIN:ZDB-GENE-020419-17	DANRE03930
Saccharomyces cerevisiae S288C	855751		SGD:S000005300