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Guidelines

MIRAGE

chromatin assembly factor 1 subunit A

Summary

Gene Symbol

CHAF1A

Organism

Homo sapiens (human)

External Links

NCBI Gene

10036

PubChem

10036

Alliance of Genome Resources

HGNC:1910

Annotation

Keyword

3D-structure
Alternative splicing
Cell cycle
Chaperone
DNA repair
DNA replication
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13111	Chromatin assembly factor I p150 subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
DNA replication	IEA
DNA repair	IEA
nucleosome assembly	IDA	14718166
nucleosome assembly	IBA
DNA replication-dependent chromatin assembly	IDA	8858152 9614144

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

protein-DNA complex organization [inference]

chromatin organization [inference]

DNA replication-dependent chromatin assembly

chromatin remodeling [inference]

nucleosome organization [inference]

nucleosome assembly

protein-DNA complex assembly [inference]

nucleosome assembly

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chromatin	IDA	14718166 9614144
nucleus	IBA
protein-containing complex	IDA	14718166
CAF-1 complex	IDA	8858152
CAF-1 complex	IBA

GO Hierarchy

cellular component

protein-containing complex

protein-DNA complex [inference]

chromatin

CAF-1 complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chromatin binding	TAS	7600578
protein binding	IPI	15805117 16826239 17474147 19498464 20562864 20936779 21570500 23075851 24981860 25416956 26496610 27705803 31980649 32296183 33961781 35271311
identical protein binding	IPI	16826239
unfolded protein binding	TAS	7600578
chromo shadow domain binding	IPI	15882967

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

chromo shadow domain binding

protein-containing complex binding [inference]

chromatin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Chromatin assembly factor 1, subunit A

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
nucleosome assembly

Displaying 1 entry
InterPro
Chromatin assembly factor 1 subunit A

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:219	colon cancer	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:769	neuroblastoma	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 50 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10036	Xenbase:XB-GENE-1001155
Mus musculus	27221	Xenbase:XB-GENE-1001155	MOUSE20078
Rattus norvegicus	363333		RATNO42504
Pan troglodytes	455603		PANTR16831
Canis lupus familiaris	485038		CANLF08008
Bos taurus	504535		BOVIN32874
Macaca mulatta	721861		MACMU20691
Monodelphis domestica	100023082		MONDO17567
Ornithorhynchus anatinus	100083564		ORNAN30285
Callithrix jacchus	100401853		CALJA23191

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: March 31, 2025